BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID of Ligand	PubChem SID of Ligand	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence	PDB ID(s) of Target Chain	UniProt (SwissProt) Recommended Name of Target Chain	UniProt (SwissProt) Entry Name of Target Chain	UniProt (SwissProt) Primary ID of Target Chain	UniProt (SwissProt) Secondary ID(s) of Target Chain	UniProt (SwissProt) Alternative ID(s) of Target Chain	UniProt (TrEMBL) Submitted Name of Target Chain	UniProt (TrEMBL) Entry Name of Target Chain	UniProt (TrEMBL) Primary ID of Target Chain	UniProt (TrEMBL) Secondary ID(s) of Target Chain	UniProt (TrEMBL) Alternative ID(s) of Target Chain
29447	CSCC[C@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCc1ccccc1	InChI=1S/C37H63N5O7S/c1-22(2)19-28(29(43)20-25(7)32(44)41-30(23(3)4)34(46)38-21-26-15-13-12-14-16-26)40-33(45)27(17-18-50-11)39-35(47)31(24(5)6)42-36(48)49-37(8,9)10/h12-16,22-25,27-31,43H,17-21H2,1-11H3,(H,38,46)(H,39,47)(H,40,45)(H,41,44)(H,42,48)/t25-,27+,28+,29+,30+,31+/m1/s1	OTAKXFOXYSLTCG-KNSFHFJMSA-N	16250	CHEMBL290001::N-(tert-butoxycarbonyl)-L-valyl-N-[(1S,2S,4R)-5-{[(1S)-1-(benzylcarbamoyl)-2-methylpropyl]amino}-2-hydroxy-4-methyl-1-(2-methylpropyl)-5-oxopentyl]-L-methioninamide::Substrate-based BACE-1 inhibitor, 22::Tang hydroxyethylene inhibitor::peptidomimetic memapsin 2 inhibitor 2::tert-butyl N-[(1S)-1-{[(1S)-1-{[(1R,3S,4S)-1-{[(1S)-1-(benzylcarbamoyl)-2-methylpropyl]carbamoyl}-3-hydroxy-1,6-dimethylheptan-4-yl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}-2-methylpropyl]carbamate	Beta-secretase 2		 1.2						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/ja058636j	10.7270/Q26W98BN	16620080	aid1797486		Ghosh, AK; Kumaragurubaran, N; Hong, L; Lei, H; Hussain, KA; Liu, CF; Devasamudram, T; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10212352	46516094		CHEMBL290001				ZINC26176801	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29448	CSCC[C@H](NC(=O)OCn1nc(C)cc1C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCc1ccccc1	InChI=1S/C34H54N6O6S/c1-21(2)16-28(36-32(43)27(14-15-47-8)37-34(45)46-20-40-25(7)18-24(6)39-40)29(41)17-23(5)31(42)38-30(22(3)4)33(44)35-19-26-12-10-9-11-13-26/h9-13,18,21-23,27-30,41H,14-17,19-20H2,1-8H3,(H,35,44)(H,36,43)(H,37,45)(H,38,42)/t23-,27+,28+,29+,30+/m1/s1	ULDYEMFEBUTYDX-UYVIBWFJSA-N	16251	(3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1S)-1-{[(1R,3S,4S)-1-{[(1S)-1-(benzylcarbamoyl)-2-methylpropyl]carbamoyl}-3-hydroxy-1,6-dimethylheptan-4-yl]carbamoyl}-3-(methylsulfanyl)propyl]carbamate::N-benzyl-N2-{(2R,4S,5S)-5-[(N-{[(3,5-dimethyl-1H-pyrazol-1-yl)methoxy]carbonyl}-L-methionyl)amino]-4-hydroxy-2,7-dimethyloctanoyl}-L-valinamide::pyrazole-bearing inhibitor 3	Beta-secretase 2		 811						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/ja058636j	10.7270/Q26W98BN	16620080	aid1797486		Ghosh, AK; Kumaragurubaran, N; Hong, L; Lei, H; Hussain, KA; Liu, CF; Devasamudram, T; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16251&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11657627	46516095						ZINC96300123	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29449	CSC[C@H](NC(=O)OCn1nc(C)cc1C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(C)C	InChI=1S/C30H54N6O6S/c1-17(2)11-23(25(37)12-20(7)27(38)34-26(19(5)6)29(40)31-14-18(3)4)32-28(39)24(15-43-10)33-30(41)42-16-36-22(9)13-21(8)35-36/h13,17-20,23-26,37H,11-12,14-16H2,1-10H3,(H,31,40)(H,32,39)(H,33,41)(H,34,38)/t20-,23+,24+,25+,26+/m1/s1	VLWRXSHSVDQTIF-GWCXRDAXSA-N	16252	(3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-[(2-methylpropyl)carbamoyl]propyl]carbamoyl}heptan-4-yl]carbamoyl}-2-(methylsulfanyl)ethyl]carbamate::N2-{(2R,4S,5S)-5-[(N-{[(3,5-dimethyl-1H-pyrazol-1-yl)methoxy]carbonyl}-S-methyl-L-cysteinyl)amino]-4-hydroxy-2,7-dimethyloctanoyl}-N-(2-methylpropyl)-L-valinamide::pyrazole-bearing inhibitor 4	Beta-secretase 2		 161						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/ja058636j	10.7270/Q26W98BN	16620080	aid1797486		Ghosh, AK; Kumaragurubaran, N; Hong, L; Lei, H; Hussain, KA; Liu, CF; Devasamudram, T; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16252&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11657409	46509498					C03800	ZINC10339553	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29450	CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CS(C)(=O)=O)NC(=O)OCn1nc(C)cc1C)C(C)C	InChI=1S/C30H54N6O8S/c1-17(2)11-23(25(37)12-20(7)27(38)34-26(19(5)6)29(40)31-14-18(3)4)32-28(39)24(15-45(10,42)43)33-30(41)44-16-36-22(9)13-21(8)35-36/h13,17-20,23-26,37H,11-12,14-16H2,1-10H3,(H,31,40)(H,32,39)(H,33,41)(H,34,38)/t20-,23+,24+,25+,26+/m1/s1	OFAZWNGNAATRSH-GWCXRDAXSA-N	16253	(3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-[(2-methylpropyl)carbamoyl]propyl]carbamoyl}heptan-4-yl]carbamoyl}-2-methanesulfonylethyl]carbamate::CHEMBL448008::N2-[(2R,4S,5S)-5-{[N-{[(3,5-dimethyl-1H-pyrazol-1-yl)methoxy]carbonyl}-3-(methylsulfonyl)-L-alanyl]amino}-4-hydroxy-2,7-dimethyloctanoyl]-N-(2-methylpropyl)-L-valinamide::pyrazole-bearing inhibitor 5	Beta-secretase 2		 356						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/ja058636j	10.7270/Q26W98BN	16620080	aid1797486		Ghosh, AK; Kumaragurubaran, N; Hong, L; Lei, H; Hussain, KA; Liu, CF; Devasamudram, T; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	ZPQ	2G94	6540293	46509499		CHEMBL448008				ZINC24805568	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29451	CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CS(C)(=O)=O)NC(=O)OCc1nc(C)oc1C)C(C)C	InChI=1S/C30H53N5O9S/c1-16(2)11-22(25(36)12-19(7)27(37)35-26(18(5)6)29(39)31-13-17(3)4)33-28(38)24(15-45(10,41)42)34-30(40)43-14-23-20(8)44-21(9)32-23/h16-19,22,24-26,36H,11-15H2,1-10H3,(H,31,39)(H,33,38)(H,34,40)(H,35,37)/t19-,22+,24+,25+,26+/m1/s1	UDROXIDKAFGJQP-ACAMQMCKSA-N	16254	(2,5-dimethyl-1,3-oxazol-4-yl)methyl N-[(1R)-1-{[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-[(2-methylpropyl)carbamoyl]propyl]carbamoyl}heptan-4-yl]carbamoyl}-2-methanesulfonylethyl]carbamate::CHEMBL449300::N2-[(2R,4S,5S)-5-{[N-{[(2,5-dimethyl-1,3-oxazol-4-yl)methoxy]carbonyl}-3-(methylsulfonyl)-L-alanyl]amino}-4-hydroxy-2,7-dimethyloctanoyl]-N-(2-methylpropyl)-L-valinamide::oxazolylmethyl-bearing inhibitor 6	Beta-secretase 2		 458						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/ja058636j	10.7270/Q26W98BN	16620080	aid1797486		Ghosh, AK; Kumaragurubaran, N; Hong, L; Lei, H; Hussain, KA; Liu, CF; Devasamudram, T; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11498384	46516314		CHEMBL449300				ZINC49841211	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29465	CCCNC(=O)c1cc(cc(c1)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C)N(C)S(C)(=O)=O	InChI=1S/C31H53N5O7S/c1-11-12-32-29(39)22-15-23(17-24(16-22)36(9)44(10,42)43)30(40)34-25(13-18(2)3)26(37)14-21(8)28(38)35-27(19(4)5)31(41)33-20(6)7/h15-21,25-27,37H,11-14H2,1-10H3,(H,32,39)(H,33,41)(H,34,40)(H,35,38)/t21-,25+,26+,27+/m1/s1	ASDUQZMMSYNGOP-FBZFJNBBSA-N	16256	1-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)-3-N-propylbenzene-1,3-dicarboxamide::Isophthalamide Derivative 5a	Beta-secretase 2		 340						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/jm061338s	10.7270/Q2348HNP	17432843	aid1797487		Ghosh, AK; Kumaragurubaran, N; Hong, L; Kulkarni, SS; Xu, X; Chang, W; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16659067	46516315						ZINC10339568	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29466	CC(C)C[C@H](NC(=O)c1cc(cc(c1)C(=O)NCc1nc(C)oc1C)N(C)S(C)(=O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C	InChI=1S/C34H54N6O8S/c1-18(2)12-27(29(41)13-21(7)31(42)39-30(19(3)4)34(45)36-20(5)6)38-33(44)25-14-24(15-26(16-25)40(10)49(11,46)47)32(43)35-17-28-22(8)48-23(9)37-28/h14-16,18-21,27,29-30,41H,12-13,17H2,1-11H3,(H,35,43)(H,36,45)(H,38,44)(H,39,42)/t21-,27+,29+,30+/m1/s1	HVXRCOUKAWTMKX-CXVOGFMYSA-N	16257	1-N-[(2,5-dimethyl-1,3-oxazol-4-yl)methyl]-3-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide::Isophthalamide Derivative 5b	Beta-secretase 2		 556						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/jm061338s	10.7270/Q2348HNP	17432843	aid1797487		Ghosh, AK; Kumaragurubaran, N; Hong, L; Kulkarni, SS; Xu, X; Chang, W; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16659019	46516316						ZINC28644316	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29467	CC(C)C[C@H](NC(=O)c1cc(cc(c1)C(=O)NCc1ccccc1)N(C)S(C)(=O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C	InChI=1S/C35H53N5O7S/c1-21(2)15-29(30(41)16-24(7)32(42)39-31(22(3)4)35(45)37-23(5)6)38-34(44)27-17-26(18-28(19-27)40(8)48(9,46)47)33(43)36-20-25-13-11-10-12-14-25/h10-14,17-19,21-24,29-31,41H,15-16,20H2,1-9H3,(H,36,43)(H,37,45)(H,38,44)(H,39,42)/t24-,29+,30+,31+/m1/s1	VBTSWTACQXLTDG-MOBIUZRASA-N	16258	1-N-benzyl-3-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide::Isophthalamide Derivative 5c	Beta-secretase 2		 523						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/jm061338s	10.7270/Q2348HNP	17432843	aid1797487		Ghosh, AK; Kumaragurubaran, N; Hong, L; Kulkarni, SS; Xu, X; Chang, W; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16258&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16659020	46516317						ZINC28644385	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29468	CC(C)C[C@H](NC(=O)c1cc(cc(c1)C(=O)N[C@H](C)c1ccccc1)N(C)S(C)(=O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C	InChI=1S/C36H55N5O7S/c1-21(2)16-30(31(42)17-24(7)33(43)40-32(22(3)4)36(46)37-23(5)6)39-35(45)28-18-27(19-29(20-28)41(9)49(10,47)48)34(44)38-25(8)26-14-12-11-13-15-26/h11-15,18-25,30-32,42H,16-17H2,1-10H3,(H,37,46)(H,38,44)(H,39,45)(H,40,43)/t24-,25-,30+,31+,32+/m1/s1	BJOCXJJVELLFKM-LLWRDSBASA-N	16259	1-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::GRL-7234::Isophthalamide Derivative 5d	Beta-secretase 2		 31						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/jm061338s	10.7270/Q2348HNP	17432843	aid1797487		Ghosh, AK; Kumaragurubaran, N; Hong, L; Kulkarni, SS; Xu, X; Chang, W; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16259&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	23I	2P4J	16659106	46516318						ZINC24819086	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29469	CC(C)C[C@H](NC(=O)c1cc(cc(c1)C(=O)N[C@H](CO)c1ccccc1)N(C)S(C)(=O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C	InChI=1S/C36H55N5O8S/c1-21(2)15-29(31(43)16-24(7)33(44)40-32(22(3)4)36(47)37-23(5)6)38-34(45)26-17-27(19-28(18-26)41(8)50(9,48)49)35(46)39-30(20-42)25-13-11-10-12-14-25/h10-14,17-19,21-24,29-32,42-43H,15-16,20H2,1-9H3,(H,37,47)(H,38,45)(H,39,46)(H,40,44)/t24-,29+,30-,31+,32+/m1/s1	GUIKWSZIYUANFW-KKESWQSKSA-N	16261	1-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-3-N-[(1S)-2-hydroxy-1-phenylethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide::Isophthalamide Derivative 5f	Beta-secretase 2		 397						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/jm061338s	10.7270/Q2348HNP	17432843	aid1797487		Ghosh, AK; Kumaragurubaran, N; Hong, L; Kulkarni, SS; Xu, X; Chang, W; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16659107	46516320						ZINC28644528	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29470	CC(C)C[C@H](NC(=O)c1cc(cc(c1)C(=O)NC(C)c1nc(C)oc1C)N(C)S(C)(=O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C	InChI=1S/C35H56N6O8S/c1-18(2)13-28(29(42)14-21(7)32(43)40-30(19(3)4)35(46)36-20(5)6)39-34(45)26-15-25(16-27(17-26)41(11)50(12,47)48)33(44)37-22(8)31-23(9)49-24(10)38-31/h15-22,28-30,42H,13-14H2,1-12H3,(H,36,46)(H,37,44)(H,39,45)(H,40,43)/t21-,22?,28+,29+,30+/m1/s1	RRHAZHLISKDKSA-QEOYOADQSA-N	16262	1-N-[1-(2,5-dimethyl-1,3-oxazol-4-yl)ethyl]-3-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide::Isophthalamide Derivative 5g	Beta-secretase 2		 408						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/jm061338s	10.7270/Q2348HNP	17432843	aid1797487		Ghosh, AK; Kumaragurubaran, N; Hong, L; Kulkarni, SS; Xu, X; Chang, W; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16659022	46516321						ZINC28644628	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29471	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C31H38N4O5S/c1-21(23-12-8-5-9-13-23)33-30(37)24-17-25(19-27(18-24)35(2)41(3,39)40)31(38)34-28(16-22-10-6-4-7-11-22)29(36)20-32-26-14-15-26/h4-13,17-19,21,26,28-29,32,36H,14-16,20H2,1-3H3,(H,33,37)(H,34,38)/t21-,28+,29-/m1/s1	VPNIQGRFZCTBEZ-SPTGULJVSA-N	16034	1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::5-Substituted isophthalamide, 1::CHEMBL378225::Isophthalamide Derivative 24::L-000384950::N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxypropyl]-5-[methyl(methylsulfonyl)amino]-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::hydroxyethylamine (HEA) derived inhibitor 1	Beta-secretase 2		 240						4.5	37.00 C	Curated from the literature by BindingDB	10.1021/jm061338s	10.7270/Q2348HNP	17432843	aid1797487		Ghosh, AK; Kumaragurubaran, N; Hong, L; Kulkarni, SS; Xu, X; Chang, W; Weerasena, V; Turner, R; Koelsch, G; Bilcer, G; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16034&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	5HA	3TPP,3TPR,2B8L	5287532	46516301		CHEMBL378225				ZINC14960423	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29701	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C31H38N4O5S/c1-21(23-12-8-5-9-13-23)33-30(37)24-17-25(19-27(18-24)35(2)41(3,39)40)31(38)34-28(16-22-10-6-4-7-11-22)29(36)20-32-26-14-15-26/h4-13,17-19,21,26,28-29,32,36H,14-16,20H2,1-3H3,(H,33,37)(H,34,38)/t21-,28+,29-/m1/s1	VPNIQGRFZCTBEZ-SPTGULJVSA-N	16034	1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::5-Substituted isophthalamide, 1::CHEMBL378225::Isophthalamide Derivative 24::L-000384950::N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxypropyl]-5-[methyl(methylsulfonyl)amino]-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::hydroxyethylamine (HEA) derived inhibitor 1	Beta-secretase 2			 230					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm049379g	10.7270/Q2XD0ZXT	15588077	aid1797502		Stachel, SJ; Coburn, CA; Steele, TG; Jones, KG; Loutzenhiser, EF; Gregro, AR; Rajapakse, HA; Lai, MT; Crouthamel, MC; Xu, M; Tugusheva, K; Lineberger, JE; Pietrak, BL; Espeseth, AS; Shi, XP; Chen-Dodson, E; Holloway, MK; Munshi, S; Simon, AJ; Kuo, L; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16034&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	5HA	3TPP,3TPR,2B8L	5287532	46516301		CHEMBL378225				ZINC14960423	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29702	C[C@@H](NC(=O)c1cc(NS(C)(=O)=O)cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccc(F)cc1	InChI=1S/C30H35FN4O5S/c1-19(21-8-10-24(31)11-9-21)33-29(37)22-15-23(17-26(16-22)35-41(2,39)40)30(38)34-27(14-20-6-4-3-5-7-20)28(36)18-32-25-12-13-25/h3-11,15-17,19,25,27-28,32,35-36H,12-14,18H2,1-2H3,(H,33,37)(H,34,38)/t19-,27+,28-/m1/s1	XMAYUKKFZWBWNS-KHWNGSORSA-N	16408	1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-methanesulfonamidobenzene-1,3-dicarboxamide::hydroxyethylamine containing compound 9	Beta-secretase 2			 210					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm049379g	10.7270/Q2XD0ZXT	15588077	aid1797502		Stachel, SJ; Coburn, CA; Steele, TG; Jones, KG; Loutzenhiser, EF; Gregro, AR; Rajapakse, HA; Lai, MT; Crouthamel, MC; Xu, M; Tugusheva, K; Lineberger, JE; Pietrak, BL; Espeseth, AS; Shi, XP; Chen-Dodson, E; Holloway, MK; Munshi, S; Simon, AJ; Kuo, L; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16408	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16408&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11169204	46516648						ZINC14961368	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29703	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N(C)S(C)(=O)=O)c1ccc(F)cc1	InChI=1S/C31H37FN4O5S/c1-20(22-9-11-25(32)12-10-22)34-30(38)23-16-24(18-27(17-23)36(2)42(3,40)41)31(39)35-28(15-21-7-5-4-6-8-21)29(37)19-33-26-13-14-26/h4-12,16-18,20,26,28-29,33,37H,13-15,19H2,1-3H3,(H,34,38)(H,35,39)/t20-,28+,29-/m1/s1	MVZMAKPUNIWJGT-IEXUNWISSA-N	16409	1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide::hydroxyethylamine containing compound 10	Beta-secretase 2			 69					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm049379g	10.7270/Q2XD0ZXT	15588077	aid1797502		Stachel, SJ; Coburn, CA; Steele, TG; Jones, KG; Loutzenhiser, EF; Gregro, AR; Rajapakse, HA; Lai, MT; Crouthamel, MC; Xu, M; Tugusheva, K; Lineberger, JE; Pietrak, BL; Espeseth, AS; Shi, XP; Chen-Dodson, E; Holloway, MK; Munshi, S; Simon, AJ; Kuo, L; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16409&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11410816	46516649						ZINC14961372	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29704	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN)N(C)S(C)(=O)=O)c1ccc(F)cc1	InChI=1S/C28H33FN4O5S/c1-18(20-9-11-23(29)12-10-20)31-27(35)21-14-22(16-24(15-21)33(2)39(3,37)38)28(36)32-25(26(34)17-30)13-19-7-5-4-6-8-19/h4-12,14-16,18,25-26,34H,13,17,30H2,1-3H3,(H,31,35)(H,32,36)/t18-,25+,26-/m1/s1	ASSLNEHQIJFAJZ-YKQNXRHISA-N	16410	1-N-[(2S,3R)-4-amino-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide::hydroxyethylamine containing compound 11	Beta-secretase 2			 443					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm049379g	10.7270/Q2XD0ZXT	15588077	aid1797502		Stachel, SJ; Coburn, CA; Steele, TG; Jones, KG; Loutzenhiser, EF; Gregro, AR; Rajapakse, HA; Lai, MT; Crouthamel, MC; Xu, M; Tugusheva, K; Lineberger, JE; Pietrak, BL; Espeseth, AS; Shi, XP; Chen-Dodson, E; Holloway, MK; Munshi, S; Simon, AJ; Kuo, L; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16410&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11376341	46516650						ZINC14961376	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29705	CCNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)N[C@H](C)c1ccc(F)cc1)N(C)S(C)(=O)=O	InChI=1S/C30H37FN4O5S/c1-5-32-19-28(36)27(15-21-9-7-6-8-10-21)34-30(38)24-16-23(17-26(18-24)35(3)41(4,39)40)29(37)33-20(2)22-11-13-25(31)14-12-22/h6-14,16-18,20,27-28,32,36H,5,15,19H2,1-4H3,(H,33,37)(H,34,38)/t20-,27+,28-/m1/s1	BSKMMOMBNBKWTC-JTOILGAVSA-N	16411	1-N-[(2S,3R)-4-(ethylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide::hydroxyethylamine containing compound 12	Beta-secretase 2			 260					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm049379g	10.7270/Q2XD0ZXT	15588077	aid1797502		Stachel, SJ; Coburn, CA; Steele, TG; Jones, KG; Loutzenhiser, EF; Gregro, AR; Rajapakse, HA; Lai, MT; Crouthamel, MC; Xu, M; Tugusheva, K; Lineberger, JE; Pietrak, BL; Espeseth, AS; Shi, XP; Chen-Dodson, E; Holloway, MK; Munshi, S; Simon, AJ; Kuo, L; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16411	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16411&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11421906	46516651						ZINC14961379	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29706	CC(C)S(=O)(=O)N(C)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)C(=O)N[C@H](C)c1ccccc1	InChI=1S/C33H42N4O5S/c1-22(2)43(41,42)37(4)29-19-26(32(39)35-23(3)25-13-9-6-10-14-25)18-27(20-29)33(40)36-30(17-24-11-7-5-8-12-24)31(38)21-34-28-15-16-28/h5-14,18-20,22-23,28,30-31,34,38H,15-17,21H2,1-4H3,(H,35,39)(H,36,40)/t23-,30+,31-/m1/s1	SKFPOSFEIUNPPF-YYSPBGNDSA-N	16413	1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylpropane-2-sulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::hydroxyethylamine containing compound 14	Beta-secretase 2			 360					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm049379g	10.7270/Q2XD0ZXT	15588077	aid1797502		Stachel, SJ; Coburn, CA; Steele, TG; Jones, KG; Loutzenhiser, EF; Gregro, AR; Rajapakse, HA; Lai, MT; Crouthamel, MC; Xu, M; Tugusheva, K; Lineberger, JE; Pietrak, BL; Espeseth, AS; Shi, XP; Chen-Dodson, E; Holloway, MK; Munshi, S; Simon, AJ; Kuo, L; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16413	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16413&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11342476	46516653						ZINC14961387	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
29707	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N(C)S(=O)(=O)N(C)C)c1ccccc1	InChI=1S/C32H41N5O5S/c1-22(24-13-9-6-10-14-24)34-31(39)25-18-26(20-28(19-25)37(4)43(41,42)36(2)3)32(40)35-29(17-23-11-7-5-8-12-23)30(38)21-33-27-15-16-27/h5-14,18-20,22,27,29-30,33,38H,15-17,21H2,1-4H3,(H,34,39)(H,35,40)/t22-,29+,30-/m1/s1	RTCBCUCWGQILHI-ZDERHKTGSA-N	16414	1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[(dimethylsulfamoyl)(methyl)amino]-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::hydroxyethylamine containing compound 15	Beta-secretase 2			 110					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm049379g	10.7270/Q2XD0ZXT	15588077	aid1797502		Stachel, SJ; Coburn, CA; Steele, TG; Jones, KG; Loutzenhiser, EF; Gregro, AR; Rajapakse, HA; Lai, MT; Crouthamel, MC; Xu, M; Tugusheva, K; Lineberger, JE; Pietrak, BL; Espeseth, AS; Shi, XP; Chen-Dodson, E; Holloway, MK; Munshi, S; Simon, AJ; Kuo, L; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16414	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16414&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11410903	46516654						ZINC14961391	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
30337	NC(=N)NC(=O)Cn1c(ccc1-c1ccccc1)-c1ccccc1	InChI=1S/C19H18N4O/c20-19(21)22-18(24)13-23-16(14-7-3-1-4-8-14)11-12-17(23)15-9-5-2-6-10-15/h1-12H,13H2,(H4,20,21,22,24)	WVLDNAVUCUAGDP-UHFFFAOYSA-N	16751	(N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-acetamide)::Acylguanidine, 7a::CHEMBL217068::N-(diaminomethylidene)-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide	Beta-secretase 2			>50000					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm0607451	10.7270/Q2M043NG	17034121	aid1797554		Cole, DC; Manas, ES; Stock, JR; Condon, JS; Jennings, LD; Aulabaugh, A; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jin, G; Lin, L; Lovering, FE; Malamas, MS; Stahl, ML; Strand, J; Sukhdeo, MN; Svenson, K; Turner, MJ; Wagner, E; Wu, J; Zhou, P; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16751&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	251	2QU2	11290116	46516971		CHEMBL217068	DB06930			ZINC14962105	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
30338	NC(=N)NC(=O)Cn1c(ccc1C12CC3CC(CC(C3)C1)C2)-c1ccccc1	InChI=1S/C23H28N4O/c24-22(25)26-21(28)14-27-19(18-4-2-1-3-5-18)6-7-20(27)23-11-15-8-16(12-23)10-17(9-15)13-23/h1-7,15-17H,8-14H2,(H4,24,25,26,28)	FJIMRIOSHHZOSF-UHFFFAOYSA-N	16752	2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(diaminomethylidene)acetamide::Acylguanidine, 7b	Beta-secretase 2			 12900					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm0607451	10.7270/Q2M043NG	17034121	aid1797554		Cole, DC; Manas, ES; Stock, JR; Condon, JS; Jennings, LD; Aulabaugh, A; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jin, G; Lin, L; Lovering, FE; Malamas, MS; Stahl, ML; Strand, J; Sukhdeo, MN; Svenson, K; Turner, MJ; Wagner, E; Wu, J; Zhou, P; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16752&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16090342	46516972						ZINC14962109	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
30339	CC(=O)c1ccc(Oc2ccc(cc2)-c2ccc(-c3ccccc3Cl)n2CC(=O)NC(N)=N)cc1	InChI=1S/C27H23ClN4O3/c1-17(33)18-6-10-20(11-7-18)35-21-12-8-19(9-13-21)24-14-15-25(22-4-2-3-5-23(22)28)32(24)16-26(34)31-27(29)30/h2-15H,16H2,1H3,(H4,29,30,31,34)	MIEKBLPHNQZVQQ-UHFFFAOYSA-N	16753	2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl]-1H-pyrrol-1-yl]-N-(diaminomethylidene)acetamide::Acylguanidine, 7c::CHEMBL253237::N-{2-[2-[4-(4-Acetyl-phenoxy)-phenyl]-5-(2-chloro-phenyl)-pyrrol-1-yl]-acetyl}-guanidine	Beta-secretase 2			 3200					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm0607451	10.7270/Q2M043NG	17034121	aid1797554		Cole, DC; Manas, ES; Stock, JR; Condon, JS; Jennings, LD; Aulabaugh, A; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jin, G; Lin, L; Lovering, FE; Malamas, MS; Stahl, ML; Strand, J; Sukhdeo, MN; Svenson, K; Turner, MJ; Wagner, E; Wu, J; Zhou, P; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16753&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	310	2ZDZ	11583947	46516973		CHEMBL253237				ZINC14962112	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
30340	OCCCNC(=N)NC(=O)Cn1c(ccc1C12CC3CC(CC(C3)C1)C2)-c1ccccc1	InChI=1S/C26H34N4O2/c27-25(28-9-4-10-31)29-24(32)17-30-22(21-5-2-1-3-6-21)7-8-23(30)26-14-18-11-19(15-26)13-20(12-18)16-26/h1-3,5-8,18-20,31H,4,9-17H2,(H3,27,28,29,32)	CSKSXMSGBMJKQZ-UHFFFAOYSA-N	16754	2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]acetamide::Acylguanidine, 10b	Beta-secretase 2			 3500					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm0607451	10.7270/Q2M043NG	17034121	aid1797554		Cole, DC; Manas, ES; Stock, JR; Condon, JS; Jennings, LD; Aulabaugh, A; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jin, G; Lin, L; Lovering, FE; Malamas, MS; Stahl, ML; Strand, J; Sukhdeo, MN; Svenson, K; Turner, MJ; Wagner, E; Wu, J; Zhou, P; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16754&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11640634	46516974						ZINC14962116	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
30341	CCCOc1ccc(cc1)-c1ccc(-c2ccccc2Cl)n1CC(=O)NC(=N)NCCCO	InChI=1S/C25H29ClN4O3/c1-2-16-33-19-10-8-18(9-11-19)22-12-13-23(20-6-3-4-7-21(20)26)30(22)17-24(32)29-25(27)28-14-5-15-31/h3-4,6-13,31H,2,5,14-17H2,1H3,(H3,27,28,29,32)	FDBNUXAMAFEWOP-UHFFFAOYSA-N	16755	Acylguanidine, 10d::N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)-1H-pyrrol-1-yl]acetamide	Beta-secretase 2			 340					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm0607451	10.7270/Q2M043NG	17034121	aid1797554		Cole, DC; Manas, ES; Stock, JR; Condon, JS; Jennings, LD; Aulabaugh, A; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jin, G; Lin, L; Lovering, FE; Malamas, MS; Stahl, ML; Strand, J; Sukhdeo, MN; Svenson, K; Turner, MJ; Wagner, E; Wu, J; Zhou, P; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16755	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16755&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16090348	46516975						ZINC14962120	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48377	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C31H37F3N4O4S/c1-2-36-26-17-24(18-27(19-26)38-13-6-7-14-43(38,41)42)30(40)37-28(16-22-9-4-3-5-10-22)29(39)21-35-20-23-11-8-12-25(15-23)31(32,33)34/h3-5,8-12,15,17-19,28-29,35-36,39H,2,6-7,13-14,16,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	GPMRAYXRPZKTFK-URLMMPGGSA-N	26502	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::BMCL181022 Compound 7::BMCL193664 Compound 24::BMCL193664 Compound 9::BMCL193669 Compound 8::sultam hydroxyethylamine (HEA) derivative, 1	Beta-secretase 2			 1430					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26502&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM8	2VNM	24794397	56464939						ZINC16052624	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48378	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H35F3N4O4S/c1-3-23-20-39-12-13-44(42,43)38(2)28-17-24(16-26(23)30(28)39)31(41)37-27(15-21-8-5-4-6-9-21)29(40)19-36-18-22-10-7-11-25(14-22)32(33,34)35/h4-11,14,16-17,20,27,29,36,40H,3,12-13,15,18-19H2,1-2H3,(H,37,41)/t27-,29+/m0/s1	MSHYGGHZTGSTOG-LMSSTIIKSA-N	26503	3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::BMCL193669 Compound 9::tricyclic hydroxyethylamine (HEA) derivative, 8a	Beta-secretase 2			 59					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26503&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM7	2VNN	11296859	56464940						ZINC16052623	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48379	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1ccccc1	InChI=1S/C31H36N4O4S/c1-3-24-21-35-14-15-40(38,39)34(2)28-18-25(17-26(24)30(28)35)31(37)33-27(16-22-10-6-4-7-11-22)29(36)20-32-19-23-12-8-5-9-13-23/h4-13,17-18,21,27,29,32,36H,3,14-16,19-20H2,1-2H3,(H,33,37)/t27-,29+/m0/s1	MZFWJFYQYIPXQF-LMSSTIIKSA-N	26504	N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8b	Beta-secretase 2			 3020					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26504	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26504&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11456237	56464941						ZINC44308023	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48380	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1ccccc1)N1CCCCS1(=O)=O	InChI=1S/C30H38N4O4S/c1-2-32-26-18-25(19-27(20-26)34-15-9-10-16-39(34,37)38)30(36)33-28(17-23-11-5-3-6-12-23)29(35)22-31-21-24-13-7-4-8-14-24/h3-8,11-14,18-20,28-29,31-32,35H,2,9-10,15-17,21-22H2,1H3,(H,33,36)/t28-,29+/m0/s1	WUYOJSGIKRCAKP-URLMMPGGSA-N	26505	BMCL181022 Compound 12::N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9b	Beta-secretase 2			 32360					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26505&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24878893	56464942						ZINC29039606	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48381	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)CCCC(C)C	InChI=1S/C33H48N4O4S/c1-7-25-22-37-16-17-42(40,41)36(6)29-20-26(19-27(25)31(29)37)32(39)35-28(18-24-13-9-8-10-14-24)30(38)21-34-33(4,5)15-11-12-23(2)3/h8-10,13-14,19-20,22-23,28,30,34,38H,7,11-12,15-18,21H2,1-6H3,(H,35,39)/t28-,30+/m0/s1	WICLUVROROXQTO-MFMCTBQISA-N	26506	BMCL193669 Compound 24::N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8c	Beta-secretase 2			 114					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26506&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11308212	56464943						ZINC42806162	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48382	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)CCCC(C)C)N1CCCCS1(=O)=O	InChI=1S/C32H50N4O4S/c1-6-33-27-20-26(21-28(22-27)36-17-10-11-18-41(36,39)40)31(38)35-29(19-25-14-8-7-9-15-25)30(37)23-34-32(4,5)16-12-13-24(2)3/h7-9,14-15,20-22,24,29-30,33-34,37H,6,10-13,16-19,23H2,1-5H3,(H,35,38)/t29-,30+/m0/s1	HTVIBPYYVYUSBD-XZWHSSHBSA-N	26507	N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9c	Beta-secretase 2			 7940					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26507	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26507&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24878897	56464944						ZINC42804037	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48383	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCC1	InChI=1S/C30H40N4O4S/c1-3-22-20-34-14-15-39(37,38)33(2)27-18-23(17-25(22)29(27)34)30(36)32-26(16-21-10-6-4-7-11-21)28(35)19-31-24-12-8-5-9-13-24/h4,6-7,10-11,17-18,20,24,26,28,31,35H,3,5,8-9,12-16,19H2,1-2H3,(H,32,36)/t26-,28+/m0/s1	MZZUETJXSRAUTC-XTEPFMGCSA-N	26508	BMCL193669 Compound 26::N-[(2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8d	Beta-secretase 2			 210					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26508	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26508&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11215541	56464945						ZINC42807978	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48384	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCC1)N1CCCCS1(=O)=O	InChI=1S/C29H42N4O4S/c1-2-30-25-18-23(19-26(20-25)33-15-9-10-16-38(33,36)37)29(35)32-27(17-22-11-5-3-6-12-22)28(34)21-31-24-13-7-4-8-14-24/h3,5-6,11-12,18-20,24,27-28,30-31,34H,2,4,7-10,13-17,21H2,1H3,(H,32,35)/t27-,28+/m0/s1	PKMPPUBHPJPCRL-WUFINQPMSA-N	26509	N-[(2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9d	Beta-secretase 2			 4370					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26509	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26509&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24878895	56464946						ZINC44360310	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48385	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C27H34N4O4S/c1-3-19-17-31-11-12-36(34,35)30(2)24-15-20(14-22(19)26(24)31)27(33)29-23(13-18-7-5-4-6-8-18)25(32)16-28-21-9-10-21/h4-8,14-15,17,21,23,25,28,32H,3,9-13,16H2,1-2H3,(H,29,33)/t23-,25+/m0/s1	STVPNNWNBWFITL-UKILVPOCSA-N	26510	BMCL193669 Compound 18::N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8e	Beta-secretase 2			 263					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26510&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11444313	56464947						ZINC40429666	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48386	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N1CCCCS1(=O)=O	InChI=1S/C26H36N4O4S/c1-2-27-22-15-20(16-23(17-22)30-12-6-7-13-35(30,33)34)26(32)29-24(14-19-8-4-3-5-9-19)25(31)18-28-21-10-11-21/h3-5,8-9,15-17,21,24-25,27-28,31H,2,6-7,10-14,18H2,1H3,(H,29,32)/t24-,25+/m0/s1	AMVDNFIQANYLEW-LOSJGSFVSA-N	26511	BMCL193669 Compound 17::N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9e	Beta-secretase 2			 19500					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26511	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26511&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24878946	56464948						ZINC40952890	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48387	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC	InChI=1S/C25H32N4O4S/c1-4-18-16-29-10-11-34(32,33)28(3)22-14-19(13-20(18)24(22)29)25(31)27-21(23(30)15-26-2)12-17-8-6-5-7-9-17/h5-9,13-14,16,21,23,26,30H,4,10-12,15H2,1-3H3,(H,27,31)/t21-,23+/m0/s1	GXBZBNGARSSJGU-JTHBVZDNSA-N	26512	3-ethyl-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::BMCL193669 Compound 28::tricyclic hydroxyethylamine (HEA) derivative, 8f	Beta-secretase 2			 1260					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26512	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26512&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11785880	56464949						ZINC36436615	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48388	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC)N1CCCCS1(=O)=O	InChI=1S/C24H34N4O4S/c1-3-26-20-14-19(15-21(16-20)28-11-7-8-12-33(28,31)32)24(30)27-22(23(29)17-25-2)13-18-9-5-4-6-10-18/h4-6,9-10,14-16,22-23,25-26,29H,3,7-8,11-13,17H2,1-2H3,(H,27,30)/t22-,23+/m0/s1	RGVHPEANFGTPJD-XZOQPEGZSA-N	26513	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]benzamide::sultam hydroxyethylamine (HEA) derivative, 9f	Beta-secretase 2			 47860					4.5	22.00 C	Curated from the literature by BindingDB	10.1021/jm800138h	10.7270/Q2XS5SQR	18457381	aid1798695		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; East, P; Hawkins, J; Howes, C; Hussain, I; Jeffrey, P; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26513	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26513&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24878948	56464950						ZINC40953514	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48878	CCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C31H34F3N3O4/c1-2-41-26-17-23(16-25(18-26)37-13-7-12-29(37)39)30(40)36-27(15-21-8-4-3-5-9-21)28(38)20-35-19-22-10-6-11-24(14-22)31(32,33)34/h3-6,8-11,14,16-18,27-28,35,38H,2,7,12-13,15,19-20H2,1H3,(H,36,40)/t27-,28+/m0/s1	RNICSWUEDSWABW-WUFINQPMSA-N	26768	3-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-(2-oxopyrrolidin-1-yl)benzamide::hydroxy ethylamine (HEA), 1	Beta-secretase 2			 26840							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26768&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190481	57298480						ZINC29039581	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48879	CCOc1cc(cc(c1)C1=C(C)CCC1=O)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C33H35F3N2O4/c1-3-42-27-17-24(31-21(2)12-13-29(31)39)16-25(18-27)32(41)38-28(15-22-8-5-4-6-9-22)30(40)20-37-19-23-10-7-11-26(14-23)33(34,35)36/h4-11,14,16-18,28,30,37,40H,3,12-13,15,19-20H2,1-2H3,(H,38,41)/t28-,30+/m0/s1	WWXGDXAFNGFFSZ-MFMCTBQISA-N	26769	3-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-(2-methyl-5-oxocyclopent-1-en-1-yl)benzamide::hydroxy ethylamine (HEA), 2	Beta-secretase 2			 4130							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26769	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26769&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190482	57298481						ZINC29039588	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48880	CCOc1cc(cc(c1)-c1ccccc1C(C)=O)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C35H35F3N2O4/c1-3-44-29-19-26(31-15-8-7-14-30(31)23(2)41)18-27(20-29)34(43)40-32(17-24-10-5-4-6-11-24)33(42)22-39-21-25-12-9-13-28(16-25)35(36,37)38/h4-16,18-20,32-33,39,42H,3,17,21-22H2,1-2H3,(H,40,43)/t32-,33+/m0/s1	YJKAWDNPEIHQRW-JHOUSYSJSA-N	26770	3-(2-acetylphenyl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 3	Beta-secretase 2			 3080							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26770&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190483	57298482						ZINC29039590	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48881	CCOc1cc(cc(c1)-c1ccccc1C#N)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C34H32F3N3O3/c1-2-43-29-18-26(30-14-7-6-12-25(30)20-38)17-27(19-29)33(42)40-31(16-23-9-4-3-5-10-23)32(41)22-39-21-24-11-8-13-28(15-24)34(35,36)37/h3-15,17-19,31-32,39,41H,2,16,21-22H2,1H3,(H,40,42)/t31-,32+/m0/s1	BNYUGOVGEXCJEV-AJQTZOPKSA-N	26771	3-(2-cyanophenyl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 4	Beta-secretase 2			 1050							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26771&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190484	57298483						ZINC29039592	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48882	CCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCS1(=O)=O	InChI=1S/C30H34F3N3O5S/c1-2-41-26-17-23(16-25(18-26)36-12-7-13-42(36,39)40)29(38)35-27(15-21-8-4-3-5-9-21)28(37)20-34-19-22-10-6-11-24(14-22)30(31,32)33/h3-6,8-11,14,16-18,27-28,34,37H,2,7,12-13,15,19-20H2,1H3,(H,35,38)/t27-,28+/m0/s1	QCGIDYZRRCDEKC-WUFINQPMSA-N	26772	3-(1,1-dioxo-1,2-thiazolidin-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 5	Beta-secretase 2			 4680							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26772	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26772&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190485	57298484						ZINC29039594	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48883	CCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C31H36F3N3O5S/c1-2-42-27-18-24(17-26(19-27)37-13-6-7-14-43(37,40)41)30(39)36-28(16-22-9-4-3-5-10-22)29(38)21-35-20-23-11-8-12-25(15-23)31(32,33)34/h3-5,8-12,15,17-19,28-29,35,38H,2,6-7,13-14,16,20-21H2,1H3,(H,36,39)/t28-,29+/m0/s1	OYLCLJYJJSLIFC-URLMMPGGSA-N	26773	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 6	Beta-secretase 2			 1020							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26773&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190486	57298485						ZINC29039596	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48884	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C31H37F3N4O4S/c1-2-36-26-17-24(18-27(19-26)38-13-6-7-14-43(38,41)42)30(40)37-28(16-22-9-4-3-5-10-22)29(39)21-35-20-23-11-8-12-25(15-23)31(32,33)34/h3-5,8-12,15,17-19,28-29,35-36,39H,2,6-7,13-14,16,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	GPMRAYXRPZKTFK-URLMMPGGSA-N	26502	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::BMCL181022 Compound 7::BMCL193664 Compound 24::BMCL193664 Compound 9::BMCL193669 Compound 8::sultam hydroxyethylamine (HEA) derivative, 1	Beta-secretase 2			 1430							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26502&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM8	2VNM	24794397	56464939						ZINC16052624	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48885	CCCc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C32H38F3N3O4S/c1-2-9-24-16-26(20-28(18-24)38-14-6-7-15-43(38,41)42)31(40)37-29(19-23-10-4-3-5-11-23)30(39)22-36-21-25-12-8-13-27(17-25)32(33,34)35/h3-5,8,10-13,16-18,20,29-30,36,39H,2,6-7,9,14-15,19,21-22H2,1H3,(H,37,40)/t29-,30+/m0/s1	FDUNRVDGFUHUJI-XZWHSSHBSA-N	26774	3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-propylbenzamide::hydroxy ethylamine (HEA), 8	Beta-secretase 2			 1450							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26774&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190487	57298486						ZINC29039598	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48886	CC(C)Nc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C32H39F3N4O4S/c1-22(2)37-27-17-25(18-28(19-27)39-13-6-7-14-44(39,42)43)31(41)38-29(16-23-9-4-3-5-10-23)30(40)21-36-20-24-11-8-12-26(15-24)32(33,34)35/h3-5,8-12,15,17-19,22,29-30,36-37,40H,6-7,13-14,16,20-21H2,1-2H3,(H,38,41)/t29-,30+/m0/s1	BQOZRTKLLZQOLL-XZWHSSHBSA-N	26775	3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-(propan-2-ylamino)benzamide::hydroxy ethylamine (HEA), 9	Beta-secretase 2			 1660							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26775&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190488	57298487						ZINC29039600	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48887	CCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC(F)(F)F)c1)N1CCCCS1(=O)=O	InChI=1S/C31H36F3N3O6S/c1-2-42-27-18-24(17-25(19-27)37-13-6-7-14-44(37,40)41)30(39)36-28(16-22-9-4-3-5-10-22)29(38)21-35-20-23-11-8-12-26(15-23)43-31(32,33)34/h3-5,8-12,15,17-19,28-29,35,38H,2,6-7,13-14,16,20-21H2,1H3,(H,36,39)/t28-,29+/m0/s1	YEZDYUAEDBVCGS-URLMMPGGSA-N	26776	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethoxy)phenyl]methyl}amino)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 10	Beta-secretase 2			 760							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26776&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190489	57298488						ZINC29039602	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48888	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC(F)(F)F)c1)N1CCCCS1(=O)=O	InChI=1S/C31H37F3N4O5S/c1-2-36-25-17-24(18-26(19-25)38-13-6-7-14-44(38,41)42)30(40)37-28(16-22-9-4-3-5-10-22)29(39)21-35-20-23-11-8-12-27(15-23)43-31(32,33)34/h3-5,8-12,15,17-19,28-29,35-36,39H,2,6-7,13-14,16,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	XLBWUOMBCABEHD-URLMMPGGSA-N	26777	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethoxy)phenyl]methyl}amino)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 11	Beta-secretase 2			 600							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26777&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190490	57298489						ZINC29039604	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48889	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1ccccc1)N1CCCCS1(=O)=O	InChI=1S/C30H38N4O4S/c1-2-32-26-18-25(19-27(20-26)34-15-9-10-16-39(34,37)38)30(36)33-28(17-23-11-5-3-6-12-23)29(35)22-31-21-24-13-7-4-8-14-24/h3-8,11-14,18-20,28-29,31-32,35H,2,9-10,15-17,21-22H2,1H3,(H,33,36)/t28-,29+/m0/s1	WUYOJSGIKRCAKP-URLMMPGGSA-N	26505	BMCL181022 Compound 12::N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9b	Beta-secretase 2			 32360							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26505&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24878893	56464942						ZINC29039606	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48890	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CCc2ccccc12)N1CCCCS1(=O)=O	InChI=1S/C32H40N4O4S/c1-2-33-26-19-25(20-27(21-26)36-16-8-9-17-41(36,39)40)32(38)35-30(18-23-10-4-3-5-11-23)31(37)22-34-29-15-14-24-12-6-7-13-28(24)29/h3-7,10-13,19-21,29-31,33-34,37H,2,8-9,14-18,22H2,1H3,(H,35,38)/t29-,30-,31+/m0/s1	PRQFEELAHDKHBV-RWSKJCERSA-N	26778	N-[(2S,3R)-4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::hydroxy ethylamine (HEA), 13	Beta-secretase 2			 2290							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26778&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190491	57298490						ZINC29039608	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48891	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCc2ccc(OC)cc12)N1CCCCS1(=O)=O	InChI=1S/C33H42N4O5S/c1-3-34-26-18-25(19-27(20-26)37-15-7-8-16-43(37,40)41)33(39)36-31(17-23-9-5-4-6-10-23)32(38)22-35-30-14-12-24-11-13-28(42-2)21-29(24)30/h4-6,9-11,13,18-21,30-32,34-35,38H,3,7-8,12,14-17,22H2,1-2H3,(H,36,39)/t30?,31-,32+/m0/s1	AZLWHCAOZGWHCN-XXWVNBFBSA-N	26779	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-phenylbutan-2-yl]benzamide::BMCL193664 Compound 26::hydroxy ethylamine (HEA), 14	Beta-secretase 2			 2950							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26779&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190492	57298491						ZINC29039612	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48892	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cnn(CC)c1)N1CCCCS1(=O)=O	InChI=1S/C29H40N6O4S/c1-3-31-25-15-24(16-26(17-25)35-12-8-9-13-40(35,38)39)29(37)33-27(14-22-10-6-5-7-11-22)28(36)20-30-18-23-19-32-34(4-2)21-23/h5-7,10-11,15-17,19,21,27-28,30-31,36H,3-4,8-9,12-14,18,20H2,1-2H3,(H,33,37)/t27-,28+/m0/s1	FRCSXRRNAXDKOX-WUFINQPMSA-N	26780	3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-4-{[(1-ethyl-1H-pyrazol-4-yl)methyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-5-(ethylamino)benzamide::BMCL193664 Compound 5::hydroxy ethylamine (HEA), 15	Beta-secretase 2			 6920							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26780	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26780&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190493	57298492						ZINC29039614	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48893	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1)N1CCCCS1(=O)=O	InChI=1S/C31H40N4O5S/c1-3-33-26-18-25(19-27(20-26)35-14-7-8-15-41(35,38)39)31(37)34-29(17-23-10-5-4-6-11-23)30(36)22-32-21-24-12-9-13-28(16-24)40-2/h4-6,9-13,16,18-20,29-30,32-33,36H,3,7-8,14-15,17,21-22H2,1-2H3,(H,34,37)/t29-,30+/m0/s1	SHIKCAICRTZTAO-XZWHSSHBSA-N	26781	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}-1-phenylbutan-2-yl]benzamide::hydroxy ethylamine (HEA), 16	Beta-secretase 2			 4270							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26781&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190494	57298493						ZINC29039616	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48894	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(OC)c1)N1CCCCS1(=O)=O	InChI=1S/C31H38F2N4O5S/c1-3-35-26-15-23(16-27(18-26)37-9-4-5-10-43(37,40)41)31(39)36-29(14-22-11-24(32)17-25(33)12-22)30(38)20-34-19-21-7-6-8-28(13-21)42-2/h6-8,11-13,15-18,29-30,34-35,38H,3-5,9-10,14,19-20H2,1-2H3,(H,36,39)/t29-,30+/m0/s1	OYRJVJLVRLQYHL-XZWHSSHBSA-N	26782	N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}butan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::hydroxy ethylamine (HEA), 17	Beta-secretase 2			 630							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26782&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190495	57298494						ZINC29039618	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48895	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccco1)[C@H](O)CNCc1cccc(OC)c1)N1CCCCS1(=O)=O	InChI=1S/C29H38N4O6S/c1-3-31-23-15-22(16-24(17-23)33-11-4-5-13-40(33,36)37)29(35)32-27(18-26-10-7-12-39-26)28(34)20-30-19-21-8-6-9-25(14-21)38-2/h6-10,12,14-17,27-28,30-31,34H,3-5,11,13,18-20H2,1-2H3,(H,32,35)/t27-,28+/m0/s1	DZDPXRZSBXSGCD-WUFINQPMSA-N	26783	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-1-(furan-2-yl)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}butan-2-yl]benzamide::hydroxy ethylamine (HEA), 18	Beta-secretase 2			 13215							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190496	57298495						ZINC29039620	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48896	CCNc1cc(cc(c1)C(=O)N[C@@H](Cn1cccn1)[C@H](O)CNCc1cccc(OC)c1)N1CCCCS1(=O)=O	InChI=1S/C28H38N6O5S/c1-3-30-23-15-22(16-24(17-23)34-12-4-5-13-40(34,37)38)28(36)32-26(20-33-11-7-10-31-33)27(35)19-29-18-21-8-6-9-25(14-21)39-2/h6-11,14-17,26-27,29-30,35H,3-5,12-13,18-20H2,1-2H3,(H,32,36)/t26-,27+/m0/s1	OFELJLDMFBJYRB-RRPNLBNLSA-N	26784	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}-1-(1H-pyrazol-1-yl)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 19	Beta-secretase 2			>100000							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26784&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190497	57298496						ZINC29039622	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48897	CCNc1cc(cc(c1)C(=O)N[C@@H](CC(C)C)[C@H](O)CNCc1cccc(OC)c1)N1CCCCS1(=O)=O	InChI=1S/C28H42N4O5S/c1-5-30-23-15-22(16-24(17-23)32-11-6-7-12-38(32,35)36)28(34)31-26(13-20(2)3)27(33)19-29-18-21-9-8-10-25(14-21)37-4/h8-10,14-17,20,26-27,29-30,33H,5-7,11-13,18-19H2,1-4H3,(H,31,34)/t26-,27+/m0/s1	AFXWQUICQRHFQB-RRPNLBNLSA-N	26785	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2R,3S)-2-hydroxy-1-{[(3-methoxyphenyl)methyl]amino}-5-methylhexan-3-yl]benzamide::hydroxy ethylamine (HEA), 20	Beta-secretase 2			>100000							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26785&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190498	57298497						ZINC59029412	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48898	CCNc1cc(N2CCCCS2(=O)=O)c(F)c(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1	InChI=1S/C31H39FN4O5S/c1-3-34-24-18-26(30(32)28(19-24)36-14-7-8-15-42(36,39)40)31(38)35-27(17-22-10-5-4-6-11-22)29(37)21-33-20-23-12-9-13-25(16-23)41-2/h4-6,9-13,16,18-19,27,29,33-34,37H,3,7-8,14-15,17,20-21H2,1-2H3,(H,35,38)/t27-,29+/m0/s1	UGVUREZIOUDVMM-LMSSTIIKSA-N	26786	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}-1-phenylbutan-2-yl]benzamide::hydroxy ethylamine (HEA), 21	Beta-secretase 2			 785							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26786&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190499	57298498						ZINC29039632	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48899	CCNc1cc(N2CCCCS2(=O)=O)c(F)c(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cnn(CC)c1	InChI=1S/C29H39FN6O4S/c1-3-32-23-15-24(28(30)26(16-23)36-12-8-9-13-41(36,39)40)29(38)34-25(14-21-10-6-5-7-11-21)27(37)19-31-17-22-18-33-35(4-2)20-22/h5-7,10-11,15-16,18,20,25,27,31-32,37H,3-4,8-9,12-14,17,19H2,1-2H3,(H,34,38)/t25-,27+/m0/s1	KNUSIDUILOGCPF-AHKZPQOWSA-N	26787	3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-4-{[(1-ethyl-1H-pyrazol-4-yl)methyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-5-(ethylamino)-2-fluorobenzamide::hydroxy ethylamine (HEA), 22	Beta-secretase 2			 2465							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26787&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190500	57298499						ZINC29039635	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
48900	CCNc1cc(N2CCCCS2(=O)=O)c(F)c(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C31H36F4N4O4S/c1-2-37-24-17-25(29(32)27(18-24)39-13-6-7-14-44(39,42)43)30(41)38-26(16-21-9-4-3-5-10-21)28(40)20-36-19-22-11-8-12-23(15-22)31(33,34)35/h3-5,8-12,15,17-18,26,28,36-37,40H,2,6-7,13-14,16,19-20H2,1H3,(H,38,41)/t26-,28+/m0/s1	DGEILIRHSDUTDK-XTEPFMGCSA-N	26788	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::BMCL181022 Compound 23::GSK188909	Beta-secretase 2			 177							Curated from the literature by BindingDB	10.1016/j.bmcl.2007.12.020	10.7270/Q2MC8XBP	18171615	aid1798729		Beswick, P; Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Gleave, R; Hawkins, J; Hussain, I; Johnson, CN; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Skidmore, J; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Stuart, A; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26788&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15981486	57298500						ZINC04401730	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54226	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C31H37F3N4O4S/c1-2-36-26-17-24(18-27(19-26)38-13-6-7-14-43(38,41)42)30(40)37-28(16-22-9-4-3-5-10-22)29(39)21-35-20-23-11-8-12-25(15-23)31(32,33)34/h3-5,8-12,15,17-19,28-29,35-36,39H,2,6-7,13-14,16,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	GPMRAYXRPZKTFK-URLMMPGGSA-N	26502	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::BMCL181022 Compound 7::BMCL193664 Compound 24::BMCL193664 Compound 9::BMCL193669 Compound 8::sultam hydroxyethylamine (HEA) derivative, 1	Beta-secretase 2			 4260							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26502&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM8	2VNM	24794397	56464939						ZINC16052624	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54227	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H35F3N4O4S/c1-3-23-20-39-12-13-44(42,43)38(2)28-17-24(16-26(23)30(28)39)31(41)37-27(15-21-8-5-4-6-9-21)29(40)19-36-18-22-10-7-11-25(14-22)32(33,34)35/h4-11,14,16-17,20,27,29,36,40H,3,12-13,15,18-19H2,1-2H3,(H,37,41)/t27-,29+/m0/s1	MSHYGGHZTGSTOG-LMSSTIIKSA-N	26503	3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::BMCL193669 Compound 9::tricyclic hydroxyethylamine (HEA) derivative, 8a	Beta-secretase 2			 59							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26503&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM7	2VNN	11296859	56464940						ZINC16052623	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54228	CCN1CCN2CCS(=O)(=O)N(C)C3C=C(C=C1C23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H40F3N5O4S/c1-3-39-12-13-40-14-15-45(43,44)38(2)27-18-24(19-28(39)30(27)40)31(42)37-26(17-22-8-5-4-6-9-22)29(41)21-36-20-23-10-7-11-25(16-23)32(33,34)35/h4-11,16,18-19,26-27,29-30,36,41H,3,12-15,17,20-21H2,1-2H3,(H,37,42)/t26-,27?,29+,30?/m0/s1	RRNNGAJPJXHPBJ-YOADDRSASA-N	29772	7,6,6 tricyclic sulfonamide, 10	Beta-secretase 2			 3800							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29772	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29772&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143273	85147538						ZINC49650163	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54229	CCNc1cc(cc2N(C)S(=O)(=O)CCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C31H37F3N4O4S/c1-3-36-26-17-23(18-28-25(26)13-8-14-43(41,42)38(28)2)30(40)37-27(16-21-9-5-4-6-10-21)29(39)20-35-19-22-11-7-12-24(15-22)31(32,33)34/h4-7,9-12,15,17-18,27,29,35-36,39H,3,8,13-14,16,19-20H2,1-2H3,(H,37,40)/t27-,29+/m0/s1	WQHZROCXTAISEJ-LMSSTIIKSA-N	29773	bicyclic sulfonamide analogue, 11	Beta-secretase 2			 3590							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29773&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143274	85147539						ZINC42921860	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54230	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1)N1CCCCS1(=O)=O	InChI=1S/C28H40N4O5S/c1-2-29-24-17-22(18-25(19-24)32-12-6-7-15-38(32,35)36)28(34)31-26(16-21-8-4-3-5-9-21)27(33)20-30-23-10-13-37-14-11-23/h3-5,8-9,17-19,23,26-27,29-30,33H,2,6-7,10-16,20H2,1H3,(H,31,34)/t26-,27+/m0/s1	GSMXCHRMEXPRGE-RRPNLBNLSA-N	29774	cyclized sulfonamide analogue, 12	Beta-secretase 2			 11190							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29774&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143275	85147540						ZINC43072334	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54231	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C29H38N4O5S/c1-3-21-19-33-11-14-39(36,37)32(2)26-17-22(16-24(21)28(26)33)29(35)31-25(15-20-7-5-4-6-8-20)27(34)18-30-23-9-12-38-13-10-23/h4-8,16-17,19,23,25,27,30,34H,3,9-15,18H2,1-2H3,(H,31,35)/t25-,27+/m0/s1	FBCAWJXDTWUBGJ-AHKZPQOWSA-N	29775	7,6,5 tricyclic sulfonamide, 13::BMCL193674 Compound 6	Beta-secretase 2			 490							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29775&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11786748	85147541						ZINC43120168	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54232	CCNc1cc(cc2N(C)S(=O)(=O)CCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C28H40N4O5S/c1-3-29-24-17-21(18-26-23(24)10-7-15-38(35,36)32(26)2)28(34)31-25(16-20-8-5-4-6-9-20)27(33)19-30-22-11-13-37-14-12-22/h4-6,8-9,17-18,22,25,27,29-30,33H,3,7,10-16,19H2,1-2H3,(H,31,34)/t25-,27+/m0/s1	KTXBXDPQEZZPTQ-AHKZPQOWSA-N	29776	bicyclic sulfonamide analogue, 14	Beta-secretase 2			 18710							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29776&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143276	85147542						ZINC43015336	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54233	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCCC(F)(F)F	InChI=1S/C27H33F3N4O4S/c1-3-19-17-34-11-12-39(37,38)33(2)23-15-20(14-21(19)25(23)34)26(36)32-22(13-18-7-5-4-6-8-18)24(35)16-31-10-9-27(28,29)30/h4-8,14-15,17,22,24,31,35H,3,9-13,16H2,1-2H3,(H,32,36)/t22-,24+/m0/s1	JBSIWTPPHNMPRR-LADGPHEKSA-N	29777	7,6,5 tricyclic sulfonamide, 15::BMCL193674 Compound 8	Beta-secretase 2			 28							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29777&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143277	85147543						ZINC43123453	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54234	CCNc1cc(cc2N(C)S(=O)(=O)CCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCCC(F)(F)F	InChI=1S/C26H35F3N4O4S/c1-3-31-21-15-19(16-23-20(21)10-7-13-38(36,37)33(23)2)25(35)32-22(14-18-8-5-4-6-9-18)24(34)17-30-12-11-26(27,28)29/h4-6,8-9,15-16,22,24,30-31,34H,3,7,10-14,17H2,1-2H3,(H,32,35)/t22-,24+/m0/s1	CXEAEKCTSODPSS-LADGPHEKSA-N	29778	bicyclic sulfonamide analogue, 16	Beta-secretase 2			 1230							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29778&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143278	85147544						ZINC43066708	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54235	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N1CCCCS1(=O)=O	InChI=1S/C26H36N4O4S/c1-2-27-22-15-20(16-23(17-22)30-12-6-7-13-35(30,33)34)26(32)29-24(14-19-8-4-3-5-9-19)25(31)18-28-21-10-11-21/h3-5,8-9,15-17,21,24-25,27-28,31H,2,6-7,10-14,18H2,1H3,(H,29,32)/t24-,25+/m0/s1	AMVDNFIQANYLEW-LOSJGSFVSA-N	26511	BMCL193669 Compound 17::N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9e	Beta-secretase 2			 19500							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26511	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26511&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24878946	56464948						ZINC40952890	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54236	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C27H34N4O4S/c1-3-19-17-31-11-12-36(34,35)30(2)24-15-20(14-22(19)26(24)31)27(33)29-23(13-18-7-5-4-6-8-18)25(32)16-28-21-9-10-21/h4-8,14-15,17,21,23,25,28,32H,3,9-13,16H2,1-2H3,(H,29,33)/t23-,25+/m0/s1	STVPNNWNBWFITL-UKILVPOCSA-N	26510	BMCL193669 Compound 18::N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8e	Beta-secretase 2			 263							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26510&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11444313	56464947						ZINC40429666	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54237	CCN1CCN2CCS(=O)(=O)N(C)C3C=C(C=C1C23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C27H39N5O4S/c1-3-31-11-12-32-13-14-37(35,36)30(2)23-16-20(17-24(31)26(23)32)27(34)29-22(15-19-7-5-4-6-8-19)25(33)18-28-21-9-10-21/h4-8,16-17,21-23,25-26,28,33H,3,9-15,18H2,1-2H3,(H,29,34)/t22-,23?,25+,26?/m0/s1	YINGAUWXSHHKHN-ZKWAXQEBSA-N	29779	7,6,6 tricyclic sulfonamide, 19	Beta-secretase 2			 16220							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29779&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143279	85147545						ZINC43080602	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54238	CCNc1cc(cc2N(C)S(=O)(=O)CCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C26H36N4O4S/c1-3-27-22-15-19(16-24-21(22)10-7-13-35(33,34)30(24)2)26(32)29-23(14-18-8-5-4-6-9-18)25(31)17-28-20-11-12-20/h4-6,8-9,15-16,20,23,25,27-28,31H,3,7,10-14,17H2,1-2H3,(H,29,32)/t23-,25+/m0/s1	HALKXQJKSWVOGT-UKILVPOCSA-N	29780	bicyclic sulfonamide analogue, 20	Beta-secretase 2			 13550							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29780	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29780&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143280	85147546						ZINC62233564	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54239	CCc1cn2CS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1	InChI=1S/C31H36N4O5S/c1-4-23-19-35-20-41(38,39)34(2)28-16-24(15-26(23)30(28)35)31(37)33-27(14-21-9-6-5-7-10-21)29(36)18-32-17-22-11-8-12-25(13-22)40-3/h5-13,15-16,19,27,29,32,36H,4,14,17-18,20H2,1-3H3,(H,33,37)/t27-,29+/m0/s1	BIFXFADRRVXKMW-LMSSTIIKSA-N	29781	6,6,5 tricyclic sulfonamide, 21	Beta-secretase 2			 350							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29781&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11467715	85147547						ZINC42921776	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54240	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1	InChI=1S/C32H38N4O5S/c1-4-24-21-36-13-14-42(39,40)35(2)29-18-25(17-27(24)31(29)36)32(38)34-28(16-22-9-6-5-7-10-22)30(37)20-33-19-23-11-8-12-26(15-23)41-3/h5-12,15,17-18,21,28,30,33,37H,4,13-14,16,19-20H2,1-3H3,(H,34,38)/t28-,30+/m0/s1	MNGUVHPNHVMEDL-MFMCTBQISA-N	29782	7,6,5 tricyclic sulfonamide, 22	Beta-secretase 2			 96							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29782&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	ZY1	2WF1	9938431	85147548						ZINC38998652	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54241	CCc1cn2CS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)CCCC(C)C	InChI=1S/C32H46N4O4S/c1-7-24-20-36-21-41(39,40)35(6)28-18-25(17-26(24)30(28)36)31(38)34-27(16-23-13-9-8-10-14-23)29(37)19-33-32(4,5)15-11-12-22(2)3/h8-10,13-14,17-18,20,22,27,29,33,37H,7,11-12,15-16,19,21H2,1-6H3,(H,34,38)/t27-,29+/m0/s1	GPAVTBALSLYNRZ-LMSSTIIKSA-N	29783	6,6,5 tricyclic sulfonamide, 23	Beta-secretase 2			 390							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11227430	85147549						ZINC42923527	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54242	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)CCCC(C)C	InChI=1S/C33H48N4O4S/c1-7-25-22-37-16-17-42(40,41)36(6)29-20-26(19-27(25)31(29)37)32(39)35-28(18-24-13-9-8-10-14-24)30(38)21-34-33(4,5)15-11-12-23(2)3/h8-10,13-14,19-20,22-23,28,30,34,38H,7,11-12,15-18,21H2,1-6H3,(H,35,39)/t28-,30+/m0/s1	WICLUVROROXQTO-MFMCTBQISA-N	26506	BMCL193669 Compound 24::N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8c	Beta-secretase 2			 110							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26506&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11308212	56464943						ZINC42806162	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54243	CCc1cn2CS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCC1	InChI=1S/C29H38N4O4S/c1-3-21-18-33-19-38(36,37)32(2)26-16-22(15-24(21)28(26)33)29(35)31-25(14-20-10-6-4-7-11-20)27(34)17-30-23-12-8-5-9-13-23/h4,6-7,10-11,15-16,18,23,25,27,30,34H,3,5,8-9,12-14,17,19H2,1-2H3,(H,31,35)/t25-,27+/m0/s1	JFEIECKPYMIBAC-AHKZPQOWSA-N	29784	6,6,5 tricyclic sulfonamide, 25	Beta-secretase 2			 620							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29784&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11250223	85147550						ZINC42963415	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54244	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCC1	InChI=1S/C30H40N4O4S/c1-3-22-20-34-14-15-39(37,38)33(2)27-18-23(17-25(22)29(27)34)30(36)32-26(16-21-10-6-4-7-11-21)28(35)19-31-24-12-8-5-9-13-24/h4,6-7,10-11,17-18,20,24,26,28,31,35H,3,5,8-9,12-16,19H2,1-2H3,(H,32,36)/t26-,28+/m0/s1	MZZUETJXSRAUTC-XTEPFMGCSA-N	26508	BMCL193669 Compound 26::N-[(2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8d	Beta-secretase 2			 210							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26508	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26508&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11215541	56464945						ZINC42807978	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54245	CCc1cn2CS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC	InChI=1S/C24H30N4O4S/c1-4-17-14-28-15-33(31,32)27(3)21-12-18(11-19(17)23(21)28)24(30)26-20(22(29)13-25-2)10-16-8-6-5-7-9-16/h5-9,11-12,14,20,22,25,29H,4,10,13,15H2,1-3H3,(H,26,30)/t20-,22+/m0/s1	POGMNGBOVVGHGD-RBBKRZOGSA-N	29785	6,6,5 tricyclic sulfonamide, 27	Beta-secretase 2			 1170							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29785&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11178891	85147551						ZINC38335979	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54246	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC	InChI=1S/C25H32N4O4S/c1-4-18-16-29-10-11-34(32,33)28(3)22-14-19(13-20(18)24(22)29)25(31)27-21(23(30)15-26-2)12-17-8-6-5-7-9-17/h5-9,13-14,16,21,23,26,30H,4,10-12,15H2,1-3H3,(H,27,31)/t21-,23+/m0/s1	GXBZBNGARSSJGU-JTHBVZDNSA-N	26512	3-ethyl-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::BMCL193669 Compound 28::tricyclic hydroxyethylamine (HEA) derivative, 8f	Beta-secretase 2			 1260							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26512	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26512&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11785880	56464949						ZINC36436615	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54247	CCc1cn2CCCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1	InChI=1S/C33H40N4O5S/c1-4-25-22-37-14-9-15-43(40,41)36(2)30-19-26(18-28(25)32(30)37)33(39)35-29(17-23-10-6-5-7-11-23)31(38)21-34-20-24-12-8-13-27(16-24)42-3/h5-8,10-13,16,18-19,22,29,31,34,38H,4,9,14-15,17,20-21H2,1-3H3,(H,35,39)/t29-,31+/m0/s1	ZOHZQJBRAJSDQU-IGYGKHONSA-N	29786	8,6,5 tricyclic sulfonamide, 32	Beta-secretase 2			 1860							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29786&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11578023	85147552						ZINC70622141	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54248	CCc1cn2CCCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C28H36N4O4S/c1-3-20-18-32-12-7-13-37(35,36)31(2)25-16-21(15-23(20)27(25)32)28(34)30-24(14-19-8-5-4-6-9-19)26(33)17-29-22-10-11-22/h4-6,8-9,15-16,18,22,24,26,29,33H,3,7,10-14,17H2,1-2H3,(H,30,34)/t24-,26+/m0/s1	HKWZRHATYFWBJJ-AZGAKELHSA-N	29787	8,6,5 tricyclic sulfonamide, 33	Beta-secretase 2			 5460							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29787&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143281	85147553						ZINC62233568	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54249	CCc1cn2CCS(=O)(=O)Nc3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1	InChI=1S/C31H36N4O5S/c1-3-23-20-35-12-13-41(38,39)34-28-17-24(16-26(23)30(28)35)31(37)33-27(15-21-8-5-4-6-9-21)29(36)19-32-18-22-10-7-11-25(14-22)40-2/h4-11,14,16-17,20,27,29,32,34,36H,3,12-13,15,18-19H2,1-2H3,(H,33,37)/t27-,29+/m0/s1	WPHAMDWBDNXCBJ-LMSSTIIKSA-N	29788	7,6,5 tricyclic sulfonamide, 34	Beta-secretase 2			 1047							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29788&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11215318	85147554						ZINC42920398	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54250	CCN1c2cc(cc3c(CC)cn(CCS1(=O)=O)c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C30H40N4O5S/c1-3-22-20-33-12-15-40(37,38)34(4-2)27-18-23(17-25(22)29(27)33)30(36)32-26(16-21-8-6-5-7-9-21)28(35)19-31-24-10-13-39-14-11-24/h5-9,17-18,20,24,26,28,31,35H,3-4,10-16,19H2,1-2H3,(H,32,36)/t26-,28+/m0/s1	VHIKANGIVZQCPI-XTEPFMGCSA-N	29789	7,6,5 tricyclic sulfonamide, 35	Beta-secretase 2			 150							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29789&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11444912	85147555						ZINC43122439	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54251	CCc1cn2CCS(=O)(=O)N(C(C)C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C31H42N4O5S/c1-4-23-20-34-12-15-41(38,39)35(21(2)3)28-18-24(17-26(23)30(28)34)31(37)33-27(16-22-8-6-5-7-9-22)29(36)19-32-25-10-13-40-14-11-25/h5-9,17-18,20-21,25,27,29,32,36H,4,10-16,19H2,1-3H3,(H,33,37)/t27-,29+/m0/s1	BKJAHVKDVOINBT-LMSSTIIKSA-N	29790	7,6,5 tricyclic sulfonamide, 36	Beta-secretase 2			 940							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29790	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29790&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11467778	85147556						ZINC42920203	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54252	CCc1cn2CCS(=O)(=O)N(CC(F)(F)F)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C30H37F3N4O5S/c1-2-21-18-36-10-13-43(40,41)37(19-30(31,32)33)26-16-22(15-24(21)28(26)36)29(39)35-25(14-20-6-4-3-5-7-20)27(38)17-34-23-8-11-42-12-9-23/h3-7,15-16,18,23,25,27,34,38H,2,8-14,17,19H2,1H3,(H,35,39)/t25-,27+/m0/s1	GLEZETRPRUIAGJ-AHKZPQOWSA-N	29791	7,6,5 tricyclic sulfonamide, 37	Beta-secretase 2			 680							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29791&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11377351	85147557						ZINC42965485	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54253	CCN1c2cc(cc3c(CC)cn(CCS1(=O)=O)c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCC1	InChI=1S/C31H42N4O4S/c1-3-23-21-34-15-16-40(38,39)35(4-2)28-19-24(18-26(23)30(28)34)31(37)33-27(17-22-11-7-5-8-12-22)29(36)20-32-25-13-9-6-10-14-25/h5,7-8,11-12,18-19,21,25,27,29,32,36H,3-4,6,9-10,13-17,20H2,1-2H3,(H,33,37)/t27-,29+/m0/s1	XBSGWVTXAJRWKB-LMSSTIIKSA-N	29792	7,6,5 tricyclic sulfonamide, 38	Beta-secretase 2			 89							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29792	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29792&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11227304	85147558						ZINC42963555	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54254	CCN1c2cc(cc3c(CC)cn(CCS1(=O)=O)c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C28H36N4O4S/c1-3-20-18-31-12-13-37(35,36)32(4-2)25-16-21(15-23(20)27(25)31)28(34)30-24(14-19-8-6-5-7-9-19)26(33)17-29-22-10-11-22/h5-9,15-16,18,22,24,26,29,33H,3-4,10-14,17H2,1-2H3,(H,30,34)/t24-,26+/m0/s1	NPKMQRVOVLQVSN-AZGAKELHSA-N	29793	7,6,5 tricyclic sulfonamide, 39	Beta-secretase 2			 331							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.150	10.7270/Q29885BR	19477642	aid1799033		Charrier, N; Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29793	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29793&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143282	85147559						ZINC42923591	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54157	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C31H35F3N4O3/c1-2-36-25-16-23(17-26(18-25)38-13-7-12-29(38)40)30(41)37-27(15-21-8-4-3-5-9-21)28(39)20-35-19-22-10-6-11-24(14-22)31(32,33)34/h3-6,8-11,14,16-18,27-28,35-36,39H,2,7,12-13,15,19-20H2,1H3,(H,37,41)/t27-,28+/m0/s1	QPGDTFHILHXFBQ-WUFINQPMSA-N	29756	CHEMBL403429::hydroxyethylamine derivative, 6	Beta-secretase 2			 4485					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29756&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG6	2VJ7	10008157	85147522		CHEMBL403429				ZINC16052618	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54158	CCNc1cc(cc(N2CCCC2=O)c1C)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H37F3N4O3/c1-3-37-26-17-24(18-28(21(26)2)39-14-8-13-30(39)41)31(42)38-27(16-22-9-5-4-6-10-22)29(40)20-36-19-23-11-7-12-25(15-23)32(33,34)35/h4-7,9-12,15,17-18,27,29,36-37,40H,3,8,13-14,16,19-20H2,1-2H3,(H,38,42)/t27-,29+/m0/s1	XSDWSIBQQPTUOF-LMSSTIIKSA-N	29757	hydroxyethylamine derivative, 7	Beta-secretase 2			 9120					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29757	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29757&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143258	85147523						ZINC44359429	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54159	CCNc1cc(cc(N2CCCC2=O)c1OC)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H37F3N4O4/c1-3-37-26-17-23(18-27(30(26)43-2)39-14-8-13-29(39)41)31(42)38-25(16-21-9-5-4-6-10-21)28(40)20-36-19-22-11-7-12-24(15-22)32(33,34)35/h4-7,9-12,15,17-18,25,28,36-37,40H,3,8,13-14,16,19-20H2,1-2H3,(H,38,42)/t25-,28+/m0/s1	GKNLPEWXTIMDRO-LBNVMWSVSA-N	29758	hydroxyethylamine derivative, 8	Beta-secretase 2			 8130					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29758	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29758&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143259	85147524						ZINC44280659	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54160	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C31H37F3N4O4S/c1-2-36-26-17-24(18-27(19-26)38-13-6-7-14-43(38,41)42)30(40)37-28(16-22-9-4-3-5-10-22)29(39)21-35-20-23-11-8-12-25(15-23)31(32,33)34/h3-5,8-12,15,17-19,28-29,35-36,39H,2,6-7,13-14,16,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	GPMRAYXRPZKTFK-URLMMPGGSA-N	26502	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::BMCL181022 Compound 7::BMCL193664 Compound 24::BMCL193664 Compound 9::BMCL193669 Compound 8::sultam hydroxyethylamine (HEA) derivative, 1	Beta-secretase 2			 1160					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26502&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM8	2VNM	24794397	56464939						ZINC16052624	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54161	CCNc1cc(cc(N2CCCCS2(=O)=O)c1C)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H39F3N4O4S/c1-3-37-27-18-25(19-29(22(27)2)39-14-7-8-15-44(39,42)43)31(41)38-28(17-23-10-5-4-6-11-23)30(40)21-36-20-24-12-9-13-26(16-24)32(33,34)35/h4-6,9-13,16,18-19,28,30,36-37,40H,3,7-8,14-15,17,20-21H2,1-2H3,(H,38,41)/t28-,30+/m0/s1	GYMHELIUJKCORO-MFMCTBQISA-N	29759	hydroxyethylamine derivative, 10	Beta-secretase 2			 7080					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29759&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143260	85147525						ZINC42834921	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54162	CCNc1cc(cc(N2CCCCS2(=O)=O)c1OC)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H39F3N4O5S/c1-3-37-27-18-24(19-28(30(27)44-2)39-14-7-8-15-45(39,42)43)31(41)38-26(17-22-10-5-4-6-11-22)29(40)21-36-20-23-12-9-13-25(16-23)32(33,34)35/h4-6,9-13,16,18-19,26,29,36-37,40H,3,7-8,14-15,17,20-21H2,1-2H3,(H,38,41)/t26-,29+/m0/s1	GDPXKICHFRFONP-LITSAYRRSA-N	29760	hydroxyethylamine derivative, 11	Beta-secretase 2			 4170					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29760	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29760&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143261	85147526						ZINC49888934	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54163	CCn1cnc2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C32H34F3N5O3/c1-2-39-20-37-30-26(39)16-23(17-27(30)40-13-7-12-29(40)42)31(43)38-25(15-21-8-4-3-5-9-21)28(41)19-36-18-22-10-6-11-24(14-22)32(33,34)35/h3-6,8-11,14,16-17,20,25,28,36,41H,2,7,12-13,15,18-19H2,1H3,(H,38,43)/t25-,28+/m0/s1	JTMOMHWUYKYKBN-LBNVMWSVSA-N	29761	hydroxyethylamine derivative, 16	Beta-secretase 2			 5750					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29761&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143262	85147527						ZINC42807712	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54164	CCn1ccc2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C33H35F3N4O3/c1-2-39-15-13-26-28(39)18-24(19-29(26)40-14-7-12-31(40)42)32(43)38-27(17-22-8-4-3-5-9-22)30(41)21-37-20-23-10-6-11-25(16-23)33(34,35)36/h3-6,8-11,13,15-16,18-19,27,30,37,41H,2,7,12,14,17,20-21H2,1H3,(H,38,43)/t27-,30+/m0/s1	BJAZGJCGTUFTCO-BHBYDHKZSA-N	29762	hydroxyethylamine derivative, 17	Beta-secretase 2			 8320					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29762	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29762&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143263	85147528						ZINC42803087	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54165	CCc1c[nH]c2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C33H35F3N4O3/c1-2-23-19-38-31-26(23)16-24(17-28(31)40-13-7-12-30(40)42)32(43)39-27(15-21-8-4-3-5-9-21)29(41)20-37-18-22-10-6-11-25(14-22)33(34,35)36/h3-6,8-11,14,16-17,19,27,29,37-38,41H,2,7,12-13,15,18,20H2,1H3,(H,39,43)/t27-,29+/m0/s1	MHUJDBRPTZFLGV-LMSSTIIKSA-N	29763	hydroxyethylamine derivative, 18a	Beta-secretase 2			 5750					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29763	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29763&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143264	85147529						ZINC44306788	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54166	CCn1ncc2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C32H34F3N5O3/c1-2-40-28-17-23(16-27(25(28)19-37-40)39-13-7-12-30(39)42)31(43)38-26(15-21-8-4-3-5-9-21)29(41)20-36-18-22-10-6-11-24(14-22)32(33,34)35/h3-6,8-11,14,16-17,19,26,29,36,41H,2,7,12-13,15,18,20H2,1H3,(H,38,43)/t26-,29+/m0/s1	JWSLPJZVLFZEJV-LITSAYRRSA-N	29764	hydroxyethylamine derivative, 19	Beta-secretase 2			 6310					4.5	22.00 C	Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29764	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29764&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143265	85147530						ZINC44351753	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54167	CCn1nnc2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C31H33F3N6O3/c1-2-40-26-17-22(16-25(29(26)37-38-40)39-13-7-12-28(39)42)30(43)36-24(15-20-8-4-3-5-9-20)27(41)19-35-18-21-10-6-11-23(14-21)31(32,33)34/h3-6,8-11,14,16-17,24,27,35,41H,2,7,12-13,15,18-19H2,1H3,(H,36,43)/t24-,27+/m0/s1	WJVIKTWKVRMSDW-RPLLCQBOSA-N	29765	hydroxyethylamine derivative, 20	Beta-secretase 2			 8910							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29765&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143266	85147531						ZINC44350985	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54168	CCc1cn(C)c2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C34H37F3N4O3/c1-3-24-21-40(2)32-27(24)17-25(18-29(32)41-14-8-13-31(41)43)33(44)39-28(16-22-9-5-4-6-10-22)30(42)20-38-19-23-11-7-12-26(15-23)34(35,36)37/h4-7,9-12,15,17-18,21,28,30,38,42H,3,8,13-14,16,19-20H2,1-2H3,(H,39,44)/t28-,30+/m0/s1	LETZXDGOOFGVHV-MFMCTBQISA-N	29766	hydroxyethylamine derivative, 18b	Beta-secretase 2			 5130							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29766&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143267	85147532						ZINC42835176	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54169	CCc1coc2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C33H34F3N3O4/c1-2-23-20-43-31-26(23)16-24(17-28(31)39-13-7-12-30(39)41)32(42)38-27(15-21-8-4-3-5-9-21)29(40)19-37-18-22-10-6-11-25(14-22)33(34,35)36/h3-6,8-11,14,16-17,20,27,29,37,40H,2,7,12-13,15,18-19H2,1H3,(H,38,42)/t27-,29+/m0/s1	LXQLUGGTPKXSBK-LMSSTIIKSA-N	29767	hydroxyethylamine derivative, 21	Beta-secretase 2			 12590							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29767&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143268	85147533						ZINC44305790	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54170	CCc1ccnc2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C34H35F3N4O3/c1-2-24-13-14-39-32-27(24)18-25(19-29(32)41-15-7-12-31(41)43)33(44)40-28(17-22-8-4-3-5-9-22)30(42)21-38-20-23-10-6-11-26(16-23)34(35,36)37/h3-6,8-11,13-14,16,18-19,28,30,38,42H,2,7,12,15,17,20-21H2,1H3,(H,40,44)/t28-,30+/m0/s1	YDNCUOPJVVQEMT-MFMCTBQISA-N	29768	hydroxyethylamine derivative, 22	Beta-secretase 2			 13180							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29768&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	ZY0	2WF0	44143269	85147534						ZINC38998461	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54171	CCn1c2cc(cc(N3CCCC3=O)c2[nH]c1=O)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1	InChI=1S/C32H37N5O5/c1-3-36-26-17-23(18-27(30(26)35-32(36)41)37-14-8-13-29(37)39)31(40)34-25(16-21-9-5-4-6-10-21)28(38)20-33-19-22-11-7-12-24(15-22)42-2/h4-7,9-12,15,17-18,25,28,33,38H,3,8,13-14,16,19-20H2,1-2H3,(H,34,40)(H,35,41)/t25-,28+/m0/s1	RQAUBIXATGJXNE-LBNVMWSVSA-N	29769	hydroxyethylamine derivative, 23	Beta-secretase 2			 23440							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29769	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29769&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143270	85147535						ZINC44307778	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54172	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)c1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C33H41F3N4O4S/c1-4-37-27-18-24(19-28(21-27)40-15-8-9-16-45(40,43)44)31(42)39-29(17-23-11-6-5-7-12-23)30(41)22-38-32(2,3)25-13-10-14-26(20-25)33(34,35)36/h5-7,10-14,18-21,29-30,37-38,41H,4,8-9,15-17,22H2,1-3H3,(H,39,42)/t29-,30+/m0/s1	LQKSXPXJHUCHMO-XZWHSSHBSA-N	29770	hydroxyethylamine derivative, 25	Beta-secretase 2			 350							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29770&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143271	85147536						ZINC49899456	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54173	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cncc(c1)C#N)N1CCCCS1(=O)=O	InChI=1S/C30H36N6O4S/c1-2-34-26-14-25(15-27(16-26)36-10-6-7-11-41(36,39)40)30(38)35-28(13-22-8-4-3-5-9-22)29(37)21-33-20-24-12-23(17-31)18-32-19-24/h3-5,8-9,12,14-16,18-19,28-29,33-34,37H,2,6-7,10-11,13,20-21H2,1H3,(H,35,38)/t28-,29+/m0/s1	YNNNGZRXTAOFAM-URLMMPGGSA-N	29771	hydroxyethylamine derivative, 27	Beta-secretase 2			 7760							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29771&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143272	85147537						ZINC42805252	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54193	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCCS1(=O)=O	InChI=1S/C31H37F3N4O4S/c1-2-36-26-17-24(18-27(19-26)38-13-6-7-14-43(38,41)42)30(40)37-28(16-22-9-4-3-5-10-22)29(39)21-35-20-23-11-8-12-25(15-23)31(32,33)34/h3-5,8-12,15,17-19,28-29,35-36,39H,2,6-7,13-14,16,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	GPMRAYXRPZKTFK-URLMMPGGSA-N	26502	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide::BMCL181022 Compound 7::BMCL193664 Compound 24::BMCL193664 Compound 9::BMCL193669 Compound 8::sultam hydroxyethylamine (HEA) derivative, 1	Beta-secretase 2			 1410							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26502&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM8	2VNM	24794397	56464939						ZINC16052624	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54194	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCc2ccc(OC)cc12)N1CCCCS1(=O)=O	InChI=1S/C33H42N4O5S/c1-3-34-26-18-25(19-27(20-26)37-15-7-8-16-43(37,40)41)33(39)36-31(17-23-9-5-4-6-10-23)32(38)22-35-30-14-12-24-11-13-28(42-2)21-29(24)30/h4-6,9-11,13,18-21,30-32,34-35,38H,3,7-8,12,14-17,22H2,1-2H3,(H,36,39)/t30?,31-,32+/m0/s1	AZLWHCAOZGWHCN-XXWVNBFBSA-N	26779	3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-phenylbutan-2-yl]benzamide::BMCL193664 Compound 26::hydroxy ethylamine (HEA), 14	Beta-secretase 2			 2950							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.165	10.7270/Q2F18X23	19428244	aid1799029		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26779&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25190492	57298491						ZINC29039612	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993498	C[C@]1(C=CSC(N)=N1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H14ClF2N3S/c1-18(6-7-25-17(22)24-18)13-8-11(2-4-14(13)20)9-15(21)16-5-3-12(19)10-23-16/h2-10H,1H3,(H2,22,24)/b15-9-/t18-/m0/s1	KDZXSSXGZIROJU-YHTSIIMFSA-N	477880	US10889579, Example 100	Beta-secretase 2			 191							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477880&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126038	442137494							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54312	CCn1cc2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C29H38N4O5S/c1-3-33-19-21-11-14-39(36,37)32(2)25-16-22(17-26(33)28(21)25)29(35)31-24(15-20-7-5-4-6-8-20)27(34)18-30-23-9-12-38-13-10-23/h4-8,16-17,19,23-24,27,30,34H,3,9-15,18H2,1-2H3,(H,31,35)/t24-,27+/m0/s1	OSAYNAICIRJYGY-RPLLCQBOSA-N	29794	sulfonamide tricyclic analogue, 5	Beta-secretase 2			 590							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29794&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11157167	85147560						ZINC42923523	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54313	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C29H38N4O5S/c1-3-21-19-33-11-14-39(36,37)32(2)26-17-22(16-24(21)28(26)33)29(35)31-25(15-20-7-5-4-6-8-20)27(34)18-30-23-9-12-38-13-10-23/h4-8,16-17,19,23,25,27,30,34H,3,9-15,18H2,1-2H3,(H,31,35)/t25-,27+/m0/s1	FBCAWJXDTWUBGJ-AHKZPQOWSA-N	29775	7,6,5 tricyclic sulfonamide, 13::BMCL193674 Compound 6	Beta-secretase 2			 490							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29775&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11786748	85147541						ZINC43120168	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54314	CCn1cc2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCCC(F)(F)F	InChI=1S/C27H33F3N4O4S/c1-3-34-17-19-9-12-39(37,38)33(2)22-14-20(15-23(34)25(19)22)26(36)32-21(13-18-7-5-4-6-8-18)24(35)16-31-11-10-27(28,29)30/h4-8,14-15,17,21,24,31,35H,3,9-13,16H2,1-2H3,(H,32,36)/t21-,24+/m0/s1	BFPPEQNMYUIWBA-XUZZJYLKSA-N	29796	sulfonamide tricyclic analogue, 7	Beta-secretase 2			 75							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29796&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11192316	85147561						ZINC43073458	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54315	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCCC(F)(F)F	InChI=1S/C27H33F3N4O4S/c1-3-19-17-34-11-12-39(37,38)33(2)23-15-20(14-21(19)25(23)34)26(36)32-22(13-18-7-5-4-6-8-18)24(35)16-31-10-9-27(28,29)30/h4-8,14-15,17,22,24,31,35H,3,9-13,16H2,1-2H3,(H,32,36)/t22-,24+/m0/s1	JBSIWTPPHNMPRR-LADGPHEKSA-N	29777	7,6,5 tricyclic sulfonamide, 15::BMCL193674 Compound 8	Beta-secretase 2			 28							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29777&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143277	85147543						ZINC43123453	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54316	CC[C@@H](C)NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2N(C)S(=O)(=O)CCc3cn(CC)c(c1)c23	InChI=1S/C28H38N4O4S/c1-5-19(3)29-17-26(33)23(14-20-10-8-7-9-11-20)30-28(34)22-15-24-27-21(12-13-37(35,36)31(24)4)18-32(6-2)25(27)16-22/h7-11,15-16,18-19,23,26,29,33H,5-6,12-14,17H2,1-4H3,(H,30,34)/t19-,23+,26-/m1/s1	YUZALEJJOXEEJU-FRPAHBMMSA-N	10145	lysine sulfonamide analogue 9::methyl N-[(1S)-1-{[(5R)-5-[(4-aminobenzene)(2-methylpropyl)sulfonamido]-6-hydroxyhexyl]carbamoyl}-2-phenylethyl]-N-methylcarbamate::sulfonamide tricyclic analogue, 9	Beta-secretase 2			 420							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10145&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11342148	46510794						ZINC62233572	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54317	CC[C@@H](C)NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2N(C)S(=O)(=O)CCn3cc(CC)c(c1)c23	InChI=1S/C28H38N4O4S/c1-5-19(3)29-17-26(33)24(14-20-10-8-7-9-11-20)30-28(34)22-15-23-21(6-2)18-32-12-13-37(35,36)31(4)25(16-22)27(23)32/h7-11,15-16,18-19,24,26,29,33H,5-6,12-14,17H2,1-4H3,(H,30,34)/t19-,24+,26-/m1/s1	WSZHJFHSCUWOJZ-YZXAJQSBSA-N	29799	sulfonamide tricyclic analogue, 10	Beta-secretase 2			 430							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29799&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11329962	85147563						ZINC62233575	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54318	CCn1cc2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCC#C	InChI=1S/C27H32N4O4S/c1-4-12-28-17-25(32)22(14-19-9-7-6-8-10-19)29-27(33)21-15-23-26-20(11-13-36(34,35)30(23)3)18-31(5-2)24(26)16-21/h1,6-10,15-16,18,22,25,28,32H,5,11-14,17H2,2-3H3,(H,29,33)/t22-,25+/m0/s1	BQPQSYLPPXUPAF-WIOPSUGQSA-N	29800	sulfonamide tricyclic analogue, 11	Beta-secretase 2			 1490							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29800&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11295146	85147564						ZINC43018784	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54319	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCC#C	InChI=1S/C27H32N4O4S/c1-4-11-28-17-25(32)23(14-19-9-7-6-8-10-19)29-27(33)21-15-22-20(5-2)18-31-12-13-36(34,35)30(3)24(16-21)26(22)31/h1,6-10,15-16,18,23,25,28,32H,5,11-14,17H2,2-3H3,(H,29,33)/t23-,25+/m0/s1	BOWMTWSMHYUISC-UKILVPOCSA-N	29801	sulfonamide tricyclic analogue, 12	Beta-secretase 2			 3100							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29801&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11168125	85147565						ZINC38324291	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54320	CCNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2N(C)S(=O)(=O)CCc3cn(CC)c(c1)c23	InChI=1S/C26H34N4O4S/c1-4-27-16-24(31)21(13-18-9-7-6-8-10-18)28-26(32)20-14-22-25-19(11-12-35(33,34)29(22)3)17-30(5-2)23(25)15-20/h6-10,14-15,17,21,24,27,31H,4-5,11-13,16H2,1-3H3,(H,28,32)/t21-,24+/m0/s1	OTTLWNIOFJDSBI-XUZZJYLKSA-N	29802	sulfonamide tricyclic analogue, 13	Beta-secretase 2			 2170							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29802&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11478322	85147566						ZINC34581927	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54321	CCNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2N(C)S(=O)(=O)CCn3cc(CC)c(c1)c23	InChI=1S/C26H34N4O4S/c1-4-19-17-30-11-12-35(33,34)29(3)23-15-20(14-21(19)25(23)30)26(32)28-22(24(31)16-27-5-2)13-18-9-7-6-8-10-18/h6-10,14-15,17,22,24,27,31H,4-5,11-13,16H2,1-3H3,(H,28,32)/t22-,24+/m0/s1	MBEIKKKHBAEUDD-LADGPHEKSA-N	29803	sulfonamide tricyclic analogue, 14	Beta-secretase 2			 1140							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29803&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11295726	85147567						ZINC42923511	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54322	CCn1cc2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C27H34N4O4S/c1-3-31-17-19-11-12-36(34,35)30(2)23-14-20(15-24(31)26(19)23)27(33)29-22(13-18-7-5-4-6-8-18)25(32)16-28-21-9-10-21/h4-8,14-15,17,21-22,25,28,32H,3,9-13,16H2,1-2H3,(H,29,33)/t22-,25+/m0/s1	NWYPYVAFLQQNQH-WIOPSUGQSA-N	29804	sulfonamide tricyclic analogue, 15	Beta-secretase 2			 370							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29804&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11238286	85147568						ZINC43014529	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54323	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C27H34N4O4S/c1-3-19-17-31-11-12-36(34,35)30(2)24-15-20(14-22(19)26(24)31)27(33)29-23(13-18-7-5-4-6-8-18)25(32)16-28-21-9-10-21/h4-8,14-15,17,21,23,25,28,32H,3,9-13,16H2,1-2H3,(H,29,33)/t23-,25+/m0/s1	STVPNNWNBWFITL-UKILVPOCSA-N	26510	BMCL193669 Compound 18::N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::tricyclic hydroxyethylamine (HEA) derivative, 8e	Beta-secretase 2			 263							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26510&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11444313	56464947						ZINC40429666	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54324	CCc1cn2CCS(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H35F3N4O4S/c1-3-23-20-39-12-13-44(42,43)38(2)28-17-24(16-26(23)30(28)39)31(41)37-27(15-21-8-5-4-6-9-21)29(40)19-36-18-22-10-7-11-25(14-22)32(33,34)35/h4-11,14,16-17,20,27,29,36,40H,3,12-13,15,18-19H2,1-2H3,(H,37,41)/t27-,29+/m0/s1	MSHYGGHZTGSTOG-LMSSTIIKSA-N	26503	3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-9-methyl-10,10-dioxo-10-thia-1,9-diazatricyclo[6.4.1.0^{4,13}]trideca-2,4(13),5,7-tetraene-6-carboxamide::BMCL193669 Compound 9::tricyclic hydroxyethylamine (HEA) derivative, 8a	Beta-secretase 2			 59							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26503&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CM7	2VNN	11296859	56464940						ZINC16052623	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54325	CCc1cn2CCS(=O)(=O)Oc3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C31H32F3N3O5S/c1-2-22-19-37-11-12-43(40,41)42-28-16-23(15-25(22)29(28)37)30(39)36-26(14-20-7-4-3-5-8-20)27(38)18-35-17-21-9-6-10-24(13-21)31(32,33)34/h3-10,13,15-16,19,26-27,35,38H,2,11-12,14,17-18H2,1H3,(H,36,39)/t26-,27+/m0/s1	FYARDFZESROLIJ-RRPNLBNLSA-N	29805	sulfone tricyclic analogue, 18	Beta-secretase 2			 260							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29805&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143283	85147569						ZINC42920544	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54326	CCc1cn2CCS(=O)(=O)Oc3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCOCC1	InChI=1S/C28H35N3O6S/c1-2-20-18-31-10-13-38(34,35)37-26-16-21(15-23(20)27(26)31)28(33)30-24(14-19-6-4-3-5-7-19)25(32)17-29-22-8-11-36-12-9-22/h3-7,15-16,18,22,24-25,29,32H,2,8-14,17H2,1H3,(H,30,33)/t24-,25+/m0/s1	JYGITBJTSAPDMP-LOSJGSFVSA-N	29806	sulfone tricyclic analogue, 19	Beta-secretase 2			 450							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29806&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143284	85147570						ZINC70622142	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54327	CCc1cn2CCS(=O)(=O)Oc3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCC#C	InChI=1S/C26H29N3O5S/c1-3-10-27-16-23(30)22(13-18-8-6-5-7-9-18)28-26(31)20-14-21-19(4-2)17-29-11-12-35(32,33)34-24(15-20)25(21)29/h1,5-9,14-15,17,22-23,27,30H,4,10-13,16H2,2H3,(H,28,31)/t22-,23+/m0/s1	PLZZTYZARDIULX-XZOQPEGZSA-N	29807	sulfone tricyclic analogue, 20	Beta-secretase 2			 3200							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29807&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143285	85147571						ZINC43017833	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
54328	CCc1cn2CCS(=O)(=O)Oc3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C26H31N3O5S/c1-2-18-16-29-10-11-35(32,33)34-24-14-19(13-21(18)25(24)29)26(31)28-22(12-17-6-4-3-5-7-17)23(30)15-27-20-8-9-20/h3-7,13-14,16,20,22-23,27,30H,2,8-12,15H2,1H3,(H,28,31)/t22-,23+/m0/s1	GLABHUZSEHKTBW-XZOQPEGZSA-N	29808	sulfone tricyclic analogue, 21	Beta-secretase 2			 1150							Curated from the literature by BindingDB	10.1016/j.bmcl.2009.03.149	10.7270/Q25H7DKK	19406640	aid1799036		Charrier, N; Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hubbard, J; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GSK	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29808&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44143286	85147572						ZINC43020111	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
198856	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	YHYKUSGACIYRML-KRWDZBQOSA-N	47353	BDBM143220::US9029362, 173::US9687494, 25	Beta-secretase 2		 0.47						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47353&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			1484169	24824350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241524	C[C@]1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)/t16-/m0/s1	WQUQHUCOJVZXJC-INIZCTEOSA-N	116227	US10035794, Example 1::US10683287, Example 1::US8637508, 1	Beta-secretase 2			 260					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356238	199996611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241525	CC1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)	WQUQHUCOJVZXJC-UHFFFAOYSA-N	116228	US10035794, Example 2::US10683287, Example 2::US8637508, 2	Beta-secretase 2			 360					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57523959	199996612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241526	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Cl)cn2)n1	InChI=1S/C16H15ClFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)/p+1	CDJHOYHFBRGWII-UHFFFAOYSA-O	116229	US10683287, Example 3::US8637508, 3	Beta-secretase 2			 1400					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808725	199996613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241527	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H15BrFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)/p+1	HBAGGGIQIJILPN-UHFFFAOYSA-O	116230	BDBM279660::US10683287, Example 4::US8637508, 4	Beta-secretase 2			 1700					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116230&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808726	199996614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241528	Cc1cc(cnc1C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1)C#N	InChI=1S/C18H17FN6O2/c1-11-5-12(6-20)7-22-16(11)17(26)24-15-4-2-3-13(23-15)18(9-19)10-27-8-14(21)25-18/h2-5,7H,8-10H2,1H3,(H2,21,25)(H,23,24,26)/p+1	DQUIQKUFQPXKNE-UHFFFAOYSA-O	116231	BDBM279661::US8637508, 5	Beta-secretase 2			 1000					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116231&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808727	199996615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241529	NC(=S)c1ccc(nc1)C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17FN6O2S/c18-8-17(9-26-7-13(19)24-17)12-2-1-3-14(22-12)23-16(25)11-5-4-10(6-21-11)15(20)27/h1-6H,7-9H2,(H2,19,24)(H2,20,27)(H,22,23,25)/p+1	RWYPCDYBONWERI-UHFFFAOYSA-O	116232	US10683287, Example 7::US8637508, 7	Beta-secretase 2			 8700					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116232&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808728	199996616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241530	Cc1cc(cnc1C(=O)Nc1cccc(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H19F3N6O2/c1-11-7-12(8-24)9-26-15(11)16(30)28-14-6-4-5-13(27-14)18(2)10-31-19(3,17(25)29-18)20(21,22)23/h4-7,9H,10H2,1-3H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	HONUCNWSWWNZSP-RBUKOAKNSA-N	116233	US10035794, Example 8::US10683287, Example 8::US8637508, 8	Beta-secretase 2			 20					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116233&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356349	199996617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241531	C[C@@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18-/m1/s1	QSCBNUCKFXAIJL-QZTJIDSGSA-N	116234	BDBM279665::US8637508, 9	Beta-secretase 2			 9900					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116234&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355899	199996618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241532	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18+/m0/s1	QSCBNUCKFXAIJL-ZWKOTPCHSA-N	116235	US10035794, Example 10::US10683287, Example 10::US8637508, 10	Beta-secretase 2			 100					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951951	199996619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241533	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	MTNQDQUYJFDVLS-RBUKOAKNSA-N	116236	US10035794, Example 11::US10683287, Example 11::US8637508, 11	Beta-secretase 2			 12					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116236&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356221	199996620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241534	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19-/m1/s1	MTNQDQUYJFDVLS-RTBURBONSA-N	116237	US10035794, Example 12::US10683287, Example 12::US8637508, 12	Beta-secretase 2			 1300					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355933	199996621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241535	[NH3+]C1=NC(CF)(COC1)c1ccnc(NC(=O)c2ccc(Cl)cn2)c1	InChI=1S/C16H15ClFN5O2/c17-11-1-2-12(21-6-11)15(24)22-14-5-10(3-4-20-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,20,22,24)/p+1	GPJQSUWRIBDPMP-UHFFFAOYSA-O	116238	BDBM279670::US10683287, Example 14::US8637508, 14	Beta-secretase 2			 4800					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116238&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808729	199996622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241536	Cc1cc(cnc1C(=O)Nc1cc(ccn1)C1(CF)COCC([NH3+])=N1)C(N)=S	InChI=1S/C18H19FN6O2S/c1-10-4-11(16(21)28)6-23-15(10)17(26)24-14-5-12(2-3-22-14)18(8-19)9-27-7-13(20)25-18/h2-6H,7-9H2,1H3,(H2,20,25)(H2,21,28)(H,22,24,26)/p+1	OTLWVMHTRDSPSA-UHFFFAOYSA-O	116239	BDBM279671::US8637508, 15	Beta-secretase 2			 10000					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116239&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808730	199996623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241537	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19+/m0/s1	VAFUDQUXHDFJQT-RBUKOAKNSA-N	116240	US10035794, Example 16::US10683287, Example 16::US8637508, 16	Beta-secretase 2			 55					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116240&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356350	199996624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241538	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19-/m1/s1	VAFUDQUXHDFJQT-RTBURBONSA-N	116241	US10035794, Example 17::US10683287, Example 17::US8637508, 17	Beta-secretase 2			 4200					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356355	199996625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241539	NC1=NC(CF)(COC1)c1cc(NC(=O)c2ccc(Br)cn2)cnc1Cl	InChI=1S/C16H14BrClFN5O2/c17-9-1-2-12(21-4-9)15(25)23-10-3-11(14(18)22-5-10)16(7-19)8-26-6-13(20)24-16/h1-5H,6-8H2,(H2,20,24)(H,23,25)	IZGSDQIFBJRHBB-UHFFFAOYSA-N	116242	US10683287, Example 18::US8637508, 18	Beta-secretase 2			 130					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116242&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57524139	199996626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241540	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2N)C#N)n1	InChI=1S/C19H18F3N7O2/c1-17(9-31-18(2,16(25)29-17)19(20,21)22)12-4-3-5-13(27-12)28-15(30)14-11(24)6-10(7-23)8-26-14/h3-6,8H,9,24H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	QLMSSDKIDFGJDT-ZWKOTPCHSA-N	116243	US10035794, Example 19::US10683287, Example 19::US8637508, 19	Beta-secretase 2			 82					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116243&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355685	199996627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241541	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2Cl)C#N)n1	InChI=1S/C19H16ClF3N6O2/c1-17(9-31-18(2,16(25)29-17)19(21,22)23)12-4-3-5-13(27-12)28-15(30)14-11(20)6-10(7-24)8-26-14/h3-6,8H,9H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	DPIDWDAWIQYLLV-ZWKOTPCHSA-N	116244	US10035794, Example 20::US10683287, Example 20::US8637508, 20	Beta-secretase 2			 41					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116244&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356253	199996628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241542	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(Br)cc2Cl)n1	InChI=1S/C18H16BrClF3N5O2/c1-16(8-30-17(2,15(24)28-16)18(21,22)23)11-4-3-5-12(26-11)27-14(29)13-10(20)6-9(19)7-25-13/h3-7H,8H2,1-2H3,(H2,24,28)(H,26,27,29)/t16-,17+/m0/s1	VANDNQQVYPKEOC-DLBZAZTESA-N	116245	US10035794, Example 22::US10683287, Example 22::US8637508, 22	Beta-secretase 2			 5					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116245&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356247	199996629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241543	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(OCC(F)(F)F)nc2N)n1	InChI=1S/C19H19F6N7O3/c1-16(7-35-17(2,15(27)32-16)19(23,24)25)9-4-3-5-10(29-9)30-14(33)12-13(26)31-11(6-28-12)34-8-18(20,21)22/h3-6H,7-8H2,1-2H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t16-,17+/m0/s1	FFRBKRVVRVORIQ-DLBZAZTESA-N	116246	US10035794, Example 23::US8637508, 23	Beta-secretase 2			 10000					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602533	199996630							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241544	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	LHTZVIDMVHFLLF-ZWKOTPCHSA-N	116247	US10035794, Example 24::US10683287, Example 35::US8637508, 24	Beta-secretase 2			 10					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355131	199996631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241545	COc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)c1	InChI=1S/C20H21F4N5O3/c1-10-7-11(31-4)8-26-14(10)16(30)28-13-6-5-12(21)15(27-13)18(2)9-32-19(3,17(25)29-18)20(22,23)24/h5-8H,9H2,1-4H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	PWIJFDYDPIMSCV-RBUKOAKNSA-N	116248	US10035794, Example 25::US10683287, Example 25::US8637508, 25	Beta-secretase 2			 15					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356220	199996632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241546	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OCC(F)(F)F)nc2N)ccc1F	InChI=1S/C19H18F7N7O3/c1-16(6-36-17(2,15(28)33-16)19(24,25)26)12-8(20)3-4-9(30-12)31-14(34)11-13(27)32-10(5-29-11)35-7-18(21,22)23/h3-5H,6-7H2,1-2H3,(H2,27,32)(H2,28,33)(H,30,31,34)/t16-,17+/m0/s1	FKENLPZVPNVYQW-DLBZAZTESA-N	116249	US10035794, Example 26::US8637508, 26	Beta-secretase 2			 6400					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116249&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602362	199996633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241547	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2N)C#N)ccc1F	InChI=1S/C19H17F4N7O2/c1-17(8-32-18(2,16(26)30-17)19(21,22)23)14-10(20)3-4-12(28-14)29-15(31)13-11(25)5-9(6-24)7-27-13/h3-5,7H,8,25H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	MWIIPGZITGHTPU-ZWKOTPCHSA-N	116250	US10035794, Example 27::US10683287, Example 27::US8637508, 27	Beta-secretase 2			 12					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951901	199996634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241548	C[C@@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18-/m1/s1	LHTZVIDMVHFLLF-QZTJIDSGSA-N	116251	US8637508, 28	Beta-secretase 2			 1900					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116251&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355008	199996635							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241549	Cc1cc(OC(F)F)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H19F6N5O3/c1-9-6-10(34-17(22)23)7-28-13(9)15(32)30-12-5-4-11(21)14(29-12)18(2)8-33-19(3,16(27)31-18)20(24,25)26/h4-7,17H,8H2,1-3H3,(H2,27,31)(H,29,30,32)/t18-,19+/m0/s1	IEGJECJTLOSIQV-RBUKOAKNSA-N	116252	US10035794, Example 29::US10683287, Example 30::US8637508, 29	Beta-secretase 2			 24					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116252&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602949	199996636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241550	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)ccc1F	InChI=1S/C19H16ClF6N5O3/c1-17(7-33-18(2,15(27)31-17)19(24,25)26)13-10(21)3-4-11(29-13)30-14(32)12-9(20)5-8(6-28-12)34-16(22)23/h3-6,16H,7H2,1-2H3,(H2,27,31)(H,29,30,32)/t17-,18+/m0/s1	DOJQNRYLSRMQDA-ZWKOTPCHSA-N	116253	US10035794, Example 30::US10683287, Example 36::US8637508, 30	Beta-secretase 2			 24					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951915	199996637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241551	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C18H15Cl2F4N5O2/c1-16(7-31-17(2,15(25)29-16)18(22,23)24)13-10(21)3-4-11(27-13)28-14(30)12-9(20)5-8(19)6-26-12/h3-6H,7H2,1-2H3,(H2,25,29)(H,27,28,30)/t16-,17+/m0/s1	DRKAFGKWERJHKK-DLBZAZTESA-N	116254	US10035794, Example 31::US10683287, Example 31::US8637508, 31	Beta-secretase 2			 1					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951906	199996638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241552	Cc1cc(OCF)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H20F5N5O3/c1-10-6-11(32-9-21)7-27-14(10)16(31)29-13-5-4-12(22)15(28-13)18(2)8-33-19(3,17(26)30-18)20(23,24)25/h4-7H,8-9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	VZKUTAXMEIXBFQ-RBUKOAKNSA-N	116255	US10035794, Example 32::US10683287, Example 32::US8637508, 32	Beta-secretase 2			 7					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116255&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356240	199996639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241553	Cc1cnc(cn1)C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C18H18F4N6O2/c1-9-6-25-11(7-24-9)14(29)27-12-5-4-10(19)13(26-12)16(2)8-30-17(3,15(23)28-16)18(20,21)22/h4-7H,8H2,1-3H3,(H2,23,28)(H,26,27,29)/t16-,17+/m0/s1	QEEWKGAHKUUMAX-DLBZAZTESA-N	116256	US10035794, Example 33::US10683287, Example 33::US8637508, 33	Beta-secretase 2			 330					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356222	199996640							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241554	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C19H15ClF7N5O2/c1-16(7-34-17(2,15(28)32-16)19(25,26)27)13-10(21)3-4-11(30-13)31-14(33)12-9(20)5-8(6-29-12)18(22,23)24/h3-6H,7H2,1-2H3,(H2,28,32)(H,30,31,33)/t16-,17+/m0/s1	PSBBWFNMHDUTRH-DLBZAZTESA-N	116257	US10035794, Example 34::US10683287, Example 34::US8637508, 34	Beta-secretase 2			 30					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	BUH	6EQM	88602735	199996641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241555	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ncc(cc2Cl)C#N)ncc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)10-4-13(27-7-12(10)21)29-15(31)14-11(20)3-9(5-25)6-28-14/h3-4,6-7H,8H2,1-2H3,(H2,26,30)(H,27,29,31)/t17-,18+/m0/s1	RPVSVZJNXFHPNA-ZWKOTPCHSA-N	116258	US10035794, Example 35::US8637508, 35	Beta-secretase 2			 120					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116258&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356241	199996642							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241556	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ncc(OC(F)F)cc2Cl)ncc1F	InChI=1S/C19H16ClF6N5O3/c1-17(7-33-18(2,15(27)31-17)19(24,25)26)9-4-12(28-6-11(9)21)30-14(32)13-10(20)3-8(5-29-13)34-16(22)23/h3-6,16H,7H2,1-2H3,(H2,27,31)(H,28,30,32)/t17-,18+/m0/s1	QONFJNGJOVKPCS-ZWKOTPCHSA-N	116259	US10035794, Example 36::US8637508, 36	Beta-secretase 2			 280					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116259&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602761	199996643							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241557	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)COC(CF)(CF)C(N)=N1)C#N	InChI=1S/C20H19F3N6O2/c1-11-3-12(5-24)6-27-16(11)17(30)28-15-4-13(14(23)7-26-15)19(2)10-31-20(8-21,9-22)18(25)29-19/h3-4,6-7H,8-10H2,1-2H3,(H2,25,29)(H,26,28,30)/t19-/m0/s1	ZDOMSYMJUOFARG-IBGZPJMESA-N	116260	US10035794, Example 37::US10683287, Example 37::US8637508, 37	Beta-secretase 2			 430					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116260&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70351283	199996644							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241558	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m0/s1	GIKOSRRRDYUWLE-SFHVURJKSA-N	116261	US10035794, Example 38::US10683287, Example 38::US8637508, 38	Beta-secretase 2			 160					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355171	199996645							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241559	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m1/s1	GIKOSRRRDYUWLE-GOSISDBHSA-N	116262	US10035794, Example 39::US10683287, Example 39::US8637508, 39	Beta-secretase 2			 6500					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356010	199996646							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241560	NC1=N[C@](COC1)(C(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C17H12ClF3N6O2/c18-9-3-8(4-22)5-24-13(9)15(28)26-12-2-1-10(19)14(25-12)17(16(20)21)7-29-6-11(23)27-17/h1-3,5,16H,6-7H2,(H2,23,27)(H,25,26,28)/t17-/m0/s1	LVXIXHYWPFXDKS-KRWDZBQOSA-N	116263	US10035794, Example 40::US10683287, Example 40::US8637508, 40	Beta-secretase 2			 170					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116263&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356242	199996647							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241561	Cc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)n1	InChI=1S/C19H20F4N6O2/c1-9-7-25-13(10(2)26-9)15(30)28-12-6-5-11(20)14(27-12)17(3)8-31-18(4,16(24)29-17)19(21,22)23/h5-7H,8H2,1-4H3,(H2,24,29)(H,27,28,30)/t17-,18+/m0/s1	NHQMQCNPITZLAA-ZWKOTPCHSA-N	116264	US10035794, Example 41::US10683287, Example 41::US8637508, 41	Beta-secretase 2			 130					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951896	199996648							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241562	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OCCCF)nc2N)ccc1F	InChI=1S/C20H22F5N7O3/c1-18(9-35-19(2,17(27)32-18)20(23,24)25)14-10(22)4-5-11(29-14)30-16(33)13-15(26)31-12(8-28-13)34-7-3-6-21/h4-5,8H,3,6-7,9H2,1-2H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t18-,19+/m0/s1	JKHHBPZBBWGXHT-RBUKOAKNSA-N	116265	US10035794, Example 42::US10683287, Example 42::US8637508, 42	Beta-secretase 2			 1000					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116265&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356059	199996649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241563	COCCn1ccc2nc(C(=O)Nc3ccc(F)c(n3)[C@]3(C)CO[C@](C)(C(N)=N3)C(F)(F)F)c(N)nc12	InChI=1S/C22H24F4N8O3/c1-20(10-37-21(2,19(28)33-20)22(24,25)26)15-11(23)4-5-13(30-15)31-18(35)14-16(27)32-17-12(29-14)6-7-34(17)8-9-36-3/h4-7H,8-10H2,1-3H3,(H2,27,32)(H2,28,33)(H,30,31,35)/t20-,21+/m0/s1	MMFYRHYCSIOPDG-LEWJYISDSA-N	116266	US10035794, Example 43::US10683287, Example 43::US8637508, 43	Beta-secretase 2			 10000					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116266&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355173	199996650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241564	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(nc2N)C(F)(F)F)ccc1F	InChI=1S/C18H16F7N7O2/c1-15(6-34-16(2,14(27)32-15)18(23,24)25)11-7(19)3-4-9(30-11)31-13(33)10-12(26)29-8(5-28-10)17(20,21)22/h3-5H,6H2,1-2H3,(H2,26,29)(H2,27,32)(H,30,31,33)/t15-,16+/m0/s1	HUQALVJHHCENTE-JKSUJKDBSA-N	116267	US10035794, Example 44::US10683287, Example 44::US8637508, 44	Beta-secretase 2			 180					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116267&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951897	199996651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241565	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nc3ccn(CC(F)F)c3nc2N)ccc1F	InChI=1S/C21H20F6N8O2/c1-19(8-37-20(2,18(29)34-19)21(25,26)27)14-9(22)3-4-12(31-14)32-17(36)13-15(28)33-16-10(30-13)5-6-35(16)7-11(23)24/h3-6,11H,7-8H2,1-2H3,(H2,28,33)(H2,29,34)(H,31,32,36)/t19-,20+/m0/s1	WBCXJAZBPSKARJ-VQTJNVASSA-N	116268	US10035794, Example 45::US8637508, 45	Beta-secretase 2			 10000					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116268&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602589	199996652							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241566	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C17H15ClF6N6O2/c1-15(6-32-16(2,13(25)28-15)17(22,23)24)11-8(19)3-4-9(26-11)27-12(31)10-7(18)5-30(29-10)14(20)21/h3-5,14H,6H2,1-2H3,(H2,25,28)(H,26,27,31)/t15-,16+/m0/s1	UYFPRMQOSKPOQR-JKSUJKDBSA-N	116269	US10035794, Example 46::US8637508, 46	Beta-secretase 2			 5					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116269&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602590	199996653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241567	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nc3ccn(CC(F)F)c3cc2Cl)ccc1F	InChI=1S/C22H19ClF6N6O2/c1-20(9-37-21(2,19(30)34-20)22(27,28)29)17-11(24)3-4-15(32-17)33-18(36)16-10(23)7-13-12(31-16)5-6-35(13)8-14(25)26/h3-7,14H,8-9H2,1-2H3,(H2,30,34)(H,32,33,36)/t20-,21+/m0/s1	KKRXTJDWKWWIKU-LEWJYISDSA-N	116270	US10035794, Example 47::US8637508, 47	Beta-secretase 2			 5400					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116270&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602591	199996654							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
241568	COCCn1ccc2nc(C(=O)Nc3ccc(F)c(n3)[C@]3(C)CO[C@](C)(C(N)=N3)C(F)(F)F)c(Cl)cc12	InChI=1S/C23H23ClF4N6O3/c1-21(11-37-22(2,20(29)33-21)23(26,27)28)18-13(25)4-5-16(31-18)32-19(35)17-12(24)10-15-14(30-17)6-7-34(15)8-9-36-3/h4-7,10H,8-9,11H2,1-3H3,(H2,29,33)(H,31,32,35)/t21-,22+/m0/s1	LUTGKRKBQRZCOA-FCHUYYIVSA-N	116271	US10035794, Example 48::US8637508, 48	Beta-secretase 2			 10000					4.5	25.00 C	US Patent		10.7270/Q2JD4VFD		aid1800346	US8637508	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116271&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356243	199996655							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252949	C[C@@]1(N=C(N)COC[C@@H]1F)c1cc(NC2CCc3cc(Cl)cnc23)ccc1F	InChI=1S/C20H21ClF2N4O/c1-20(17(23)9-28-10-18(24)27-20)14-7-13(3-4-15(14)22)26-16-5-2-11-6-12(21)8-25-19(11)16/h3-4,6-8,16-17,26H,2,5,9-10H2,1H3,(H2,24,27)/t16?,17-,20+/m0/s1	LLVAUXCCVYNQFH-KKOVZHJLSA-N	123857	US8748418, 1	Beta-secretase 2			 24					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123857&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547140	225150263							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252950	C[C@@]1(N=C(N)COC[C@@H]1F)c1cc(NCc2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C17H18ClF4N5O/c1-17(14(20)7-28-8-15(23)25-17)10-4-9(2-3-12(10)19)24-5-13-11(18)6-27(26-13)16(21)22/h2-4,6,14,16,24H,5,7-8H2,1H3,(H2,23,25)/t14-,17+/m0/s1	RZXYOIJGPYTNGY-WMLDXEAASA-N	123858	US8748418, 2	Beta-secretase 2			 35					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123858	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123858&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547141	225150264							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252951	C[C@@]1(N=C(N)COC[C@@H]1F)c1cc(NC2CCOC2)ccc1F	InChI=1S/C16H21F2N3O2/c1-16(14(18)8-23-9-15(19)21-16)12-6-10(2-3-13(12)17)20-11-4-5-22-7-11/h2-3,6,11,14,20H,4-5,7-9H2,1H3,(H2,19,21)/t11?,14-,16+/m0/s1	UPNYTQSKKDHJPL-TWZNPMNKSA-N	123859	US8748418, 3	Beta-secretase 2			 72					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123859&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547142	225150265							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252952	C[C@@]1(N=C(N)COC[C@@H]1F)c1cc(NC2CCCOC2)ccc1F	InChI=1S/C17H23F2N3O2/c1-17(15(19)9-24-10-16(20)22-17)13-7-11(4-5-14(13)18)21-12-3-2-6-23-8-12/h4-5,7,12,15,21H,2-3,6,8-10H2,1H3,(H2,20,22)/t12?,15-,17+/m0/s1	JPKWXEFYYHRRRJ-BRCNOLGNSA-N	123860	US8748418, 4	Beta-secretase 2			 73					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123860&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547315	225150266							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252953	C[C@@]1(N=C(N)COC[C@@H]1F)c1cc(NC2CCOCC2)ccc1F	InChI=1S/C17H23F2N3O2/c1-17(15(19)9-24-10-16(20)22-17)13-8-12(2-3-14(13)18)21-11-4-6-23-7-5-11/h2-3,8,11,15,21H,4-7,9-10H2,1H3,(H2,20,22)/t15-,17+/m0/s1	AOUYERQDQWXFRI-DOTOQJQBSA-N	123861	US8748418, 5	Beta-secretase 2			 1480					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123861&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547316	225150267							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252954	C[C@@]1(N=C(N)COCC1(F)F)c1cc(NCc2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C17H17ClF5N5O/c1-16(17(22,23)8-29-7-14(24)26-16)10-4-9(2-3-12(10)19)25-5-13-11(18)6-28(27-13)15(20)21/h2-4,6,15,25H,5,7-8H2,1H3,(H2,24,26)/t16-/m1/s1	JQFSKBFJRFOZRE-MRXNPFEDSA-N	123862	US8748418, 6	Beta-secretase 2			 11					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123862&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			60194542	225150268							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252955	CC[C@@]1(N=C(N)COCC1(F)F)c1cc(NCc2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C18H19ClF5N5O/c1-2-17(18(23,24)9-30-8-15(25)27-17)11-5-10(3-4-13(11)20)26-6-14-12(19)7-29(28-14)16(21)22/h3-5,7,16,26H,2,6,8-9H2,1H3,(H2,25,27)/t17-/m1/s1	NUVPFLZJJVXOTE-QGZVFWFLSA-N	123863	US8748418, 7	Beta-secretase 2			 310					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123863&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547318	225150269							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252956	C[C@@]1(N=C(N)COCC1(F)F)c1cc(N[C@H]2CCc3cc(Cl)cnc23)ccc1F	InChI=1S/C20H20ClF3N4O/c1-19(20(23,24)10-29-9-17(25)28-19)14-7-13(3-4-15(14)22)27-16-5-2-11-6-12(21)8-26-18(11)16/h3-4,6-8,16,27H,2,5,9-10H2,1H3,(H2,25,28)/t16-,19+/m0/s1	MRMHPBKPLSGSSO-QFBILLFUSA-N	123864	US8748418, 8	Beta-secretase 2			 30					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123864&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547317	225150270							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252957	C[C@@]1(N=C(N)COCC1(F)F)c1cc(N[C@@H]2CCc3cc(Cl)cnc23)ccc1F	InChI=1S/C20H20ClF3N4O/c1-19(20(23,24)10-29-9-17(25)28-19)14-7-13(3-4-15(14)22)27-16-5-2-11-6-12(21)8-26-18(11)16/h3-4,6-8,16,27H,2,5,9-10H2,1H3,(H2,25,28)/t16-,19-/m1/s1	MRMHPBKPLSGSSO-VQIMIIECSA-N	123865	US8748418, 9	Beta-secretase 2			 650					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123865&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547319	225150271							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252958	C[C@@]1(N=C(N)COCC1(F)F)c1cc(Nc2ccc(cc2)C#N)ccc1F	InChI=1S/C19H17F3N4O/c1-18(19(21,22)11-27-10-17(24)26-18)15-8-14(6-7-16(15)20)25-13-4-2-12(9-23)3-5-13/h2-8,25H,10-11H2,1H3,(H2,24,26)/t18-/m1/s1	LBGFFZGJEKCFTP-GOSISDBHSA-N	123866	US8748418, 10	Beta-secretase 2			 910					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123866&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547320	225150272							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252959	CC1(C)OCC(N)=N[C@](C)(c2cc(N[C@H]3CCc4cc(cnc34)C#N)ccc2F)C1(F)F	InChI=1S/C23H24F3N5O/c1-21(2)23(25,26)22(3,31-19(28)12-32-21)16-9-15(5-6-17(16)24)30-18-7-4-14-8-13(10-27)11-29-20(14)18/h5-6,8-9,11,18,30H,4,7,12H2,1-3H3,(H2,28,31)/t18-,22+/m0/s1	JAWQNPDVHXPUOL-PGRDOPGGSA-N	123867	US8748418, 12	Beta-secretase 2			 5					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123867&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68307545	225150273							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252960	CC1(C)OCC(N)=N[C@](C)(c2cc(N[C@@H]3CCc4cc(cnc34)C#N)ccc2F)C1(F)F	InChI=1S/C23H24F3N5O/c1-21(2)23(25,26)22(3,31-19(28)12-32-21)16-9-15(5-6-17(16)24)30-18-7-4-14-8-13(10-27)11-29-20(14)18/h5-6,8-9,11,18,30H,4,7,12H2,1-3H3,(H2,28,31)/t18-,22-/m1/s1	JAWQNPDVHXPUOL-XMSQKQJNSA-N	123868	US8748418, 13::US8748418, 21	Beta-secretase 2			 95					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123868&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547489	225150274							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252961	CC1(C)OCC(N)=N[C@](C)(c2cc(NC3CCc4cc(Cl)cnc34)ccc2F)C1(F)F	InChI=1S/C22H24ClF3N4O/c1-20(2)22(25,26)21(3,30-18(27)11-31-20)15-9-14(5-6-16(15)24)29-17-7-4-12-8-13(23)10-28-19(12)17/h5-6,8-10,17,29H,4,7,11H2,1-3H3,(H2,27,30)/t17?,21-/m1/s1	QEQRMWYXLWHPTH-FBLFFUNLSA-N	123869	US8748418, 14	Beta-secretase 2			 28					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123869&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547488	225150275							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252962	CC1(C)OCC(N)=N[C@](C)(c2cc(NC3COc4cc(Cl)cnc34)ccc2F)C1(F)F	InChI=1S/C21H22ClF3N4O2/c1-19(2)21(24,25)20(3,29-17(26)10-31-19)13-7-12(4-5-14(13)23)28-15-9-30-16-6-11(22)8-27-18(15)16/h4-8,15,28H,9-10H2,1-3H3,(H2,26,29)/t15?,20-/m1/s1	KGAFYWZDTGMPJU-YQYDADCPSA-N	123870	US8748418, 15	Beta-secretase 2			 58					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123870&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547492	225150276							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252963	CC1(C)OCC(N)=N[C@](C)(c2cc(NC3CCCc4cc(cnc34)C#N)ccc2F)C1(F)F	InChI=1S/C24H26F3N5O/c1-22(2)24(26,27)23(3,32-20(29)13-33-22)17-10-16(7-8-18(17)25)31-19-6-4-5-15-9-14(11-28)12-30-21(15)19/h7-10,12,19,31H,4-6,13H2,1-3H3,(H2,29,32)/t19?,23-/m1/s1	DQDFNCUEKCQXCI-LEQGEALCSA-N	123871	US8748418, 16	Beta-secretase 2			 133					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123871&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547491	225150277							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252964	CC1(C)OCC(N)=N[C@](C)(c2cc(NC3COc4cc(Cl)ccc34)ccc2F)C1(F)F	InChI=1S/C22H23ClF3N3O2/c1-20(2)22(25,26)21(3,29-19(27)11-31-20)15-9-13(5-7-16(15)24)28-17-10-30-18-8-12(23)4-6-14(17)18/h4-9,17,28H,10-11H2,1-3H3,(H2,27,29)/t17?,21-/m1/s1	ONHMGVGQADMHCB-FBLFFUNLSA-N	123872	US8748418, 17	Beta-secretase 2			 400					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123872&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547493	225150278							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252965	Cn1ccc(Nc2ccc(F)c(c2)[C@@]2(C)N=C(N)COC(C)(C)C2(F)F)n1	InChI=1S/C18H22F3N5O/c1-16(2)18(20,21)17(3,24-14(22)10-27-16)12-9-11(5-6-13(12)19)23-15-7-8-26(4)25-15/h5-9H,10H2,1-4H3,(H2,22,24)(H,23,25)/t17-/m1/s1	QYGFFWAZNLLMIB-QGZVFWFLSA-N	123873	US8748418, 18	Beta-secretase 2			 530					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123873&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547657	225150279							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252966	CC1(C)OCC(N)=N[C@](C)(c2cc(Nc3ccc(F)cc3)ccc2F)C1(F)F	InChI=1S/C20H21F4N3O/c1-18(2)20(23,24)19(3,27-17(25)11-28-18)15-10-14(8-9-16(15)22)26-13-6-4-12(21)5-7-13/h4-10,26H,11H2,1-3H3,(H2,25,27)/t19-/m1/s1	CFNQAYSORUWKLN-LJQANCHMSA-N	123874	US8748418, 19	Beta-secretase 2			 4160					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123874&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547658	225150280							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252967	CC1(C)OCC(N)=N[C@](C)(c2cc(N[C@H]3CCc4cc(cnc34)C#N)c(F)cc2F)C1(F)F	InChI=1S/C23H23F4N5O/c1-21(2)23(26,27)22(3,32-19(29)11-33-21)14-7-18(16(25)8-15(14)24)31-17-5-4-13-6-12(9-28)10-30-20(13)17/h6-8,10,17,31H,4-5,11H2,1-3H3,(H2,29,32)/t17-,22+/m0/s1	ZXPMSLQQIPEYLP-HTAPYJJXSA-N	123875	US8748418, 20	Beta-secretase 2			 170					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123875&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547659	225150281							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252968	CC1(C)OCC(N)=N[C@](C)(c2cc(N[C@@H]3CCc4cc(cnc34)C#N)ccc2F)C1(F)F	InChI=1S/C23H24F3N5O/c1-21(2)23(25,26)22(3,31-19(28)12-32-21)16-9-15(5-6-17(16)24)30-18-7-4-14-8-13(10-27)11-29-20(14)18/h5-6,8-9,11,18,30H,4,7,12H2,1-3H3,(H2,28,31)/t18-,22-/m1/s1	JAWQNPDVHXPUOL-XMSQKQJNSA-N	123868	US8748418, 13::US8748418, 21	Beta-secretase 2			 2810					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123868&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547489	225150274							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252969	CC1(C)OCC(N)=N[C@](C)(c2cc(Nc3ccc(Cl)nc3)ccc2F)C1(F)F	InChI=1S/C19H20ClF3N4O/c1-17(2)19(22,23)18(3,27-16(24)10-28-17)13-8-11(4-6-14(13)21)26-12-5-7-15(20)25-9-12/h4-9,26H,10H2,1-3H3,(H2,24,27)/t18-/m1/s1	ZHRCZUUYWIYZLZ-GOSISDBHSA-N	123877	US8748418, 22	Beta-secretase 2			 1770					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547660	225150283							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252970	CC1(C)OCC(N)=N[C@](C)(c2cc(Nc3cncc(F)c3)ccc2F)C1(F)F	InChI=1S/C19H20F4N4O/c1-17(2)19(22,23)18(3,27-16(24)10-28-17)14-7-12(4-5-15(14)21)26-13-6-11(20)8-25-9-13/h4-9,26H,10H2,1-3H3,(H2,24,27)/t18-/m1/s1	QDHCAUCHZFEKAE-GOSISDBHSA-N	123878	US8748418, 23	Beta-secretase 2			 1360					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123878&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547661	225150284							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252971	CC1(C)OCC(N)=N[C@](C)(c2cc(Nc3cccnc3)ccc2F)C1(F)F	InChI=1S/C19H21F3N4O/c1-17(2)19(21,22)18(3,26-16(23)11-27-17)14-9-12(6-7-15(14)20)25-13-5-4-8-24-10-13/h4-10,25H,11H2,1-3H3,(H2,23,26)/t18-/m1/s1	XOQWCIWXRUAODU-GOSISDBHSA-N	123879	US8748418, 24	Beta-secretase 2			 940					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123879&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547827	225150285							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252972	COc1ccc(Nc2ccc(F)c(c2)[C@@]2(C)N=C(N)COC(C)(C)C2(F)F)cn1	InChI=1S/C20H23F3N4O2/c1-18(2)20(22,23)19(3,27-16(24)11-29-18)14-9-12(5-7-15(14)21)26-13-6-8-17(28-4)25-10-13/h5-10,26H,11H2,1-4H3,(H2,24,27)/t19-/m1/s1	POSSNERCWDVBPP-LJQANCHMSA-N	123880	US8748418, 25	Beta-secretase 2			 1630					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123880&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547662	225150286							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252973	CC1(C)OCC(N)=N[C@](C)(c2cc(Nc3cncc(c3)C(F)(F)F)ccc2F)C1(F)F	InChI=1S/C20H20F6N4O/c1-17(2)20(25,26)18(3,30-16(27)10-31-17)14-7-12(4-5-15(14)21)29-13-6-11(8-28-9-13)19(22,23)24/h4-9,29H,10H2,1-3H3,(H2,27,30)/t18-/m1/s1	GDPOMHIELXXKQZ-GOSISDBHSA-N	123881	US8748418, 26	Beta-secretase 2			 3890					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123881&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547824	225150287							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
252974	CC1(C)OCC(N)=N[C@](C)(c2cc(Nc3ccc(OCC(F)(F)F)nc3)ccc2F)C1(F)F	InChI=1S/C21H22F6N4O2/c1-18(2)21(26,27)19(3,31-16(28)10-33-18)14-8-12(4-6-15(14)22)30-13-5-7-17(29-9-13)32-11-20(23,24)25/h4-9,30H,10-11H2,1-3H3,(H2,28,31)/t19-/m1/s1	WBZPQQJIWRFYNT-LJQANCHMSA-N	123883	US8748418, 28	Beta-secretase 2			 1493					4.5		US Patent		10.7270/Q2C53JJP		aid1800503	US8748418	Gabellieri, E; Guba, W; Hilpert, H; Mauser, H; Mayweg, AV; Rogers-Evans, M; Rombach, D; Thomas, A; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123883&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66547826	225150289							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253269	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H15ClF2N4O2/c1-17(14(20)8-26-16(21)24-17)11-6-10(3-4-12(11)19)23-15(25)13-5-2-9(18)7-22-13/h2-7,14H,8H2,1H3,(H2,21,24)(H,23,25)/t14-,17+/m0/s1	QVPZORXMLIMRNH-WMLDXEAASA-N	124132	US8754075, 1	Beta-secretase 2			 1						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124132&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558600	225150524							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253270	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C17H14Cl2F2N4O2/c1-17(13(21)7-27-16(22)25-17)10-5-9(2-3-12(10)20)24-15(26)14-11(19)4-8(18)6-23-14/h2-6,13H,7H2,1H3,(H2,22,25)(H,24,26)/t13-,17+/m0/s1	AVJOFNVVARWCHZ-SUMWQHHRSA-N	124133	US8754075, 2	Beta-secretase 2			 8						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124133&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66557905	225150525							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253271	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ncc(F)cc2F)ccc1F	InChI=1S/C17H14F4N4O2/c1-17(13(21)7-27-16(22)25-17)10-5-9(2-3-11(10)19)24-15(26)14-12(20)4-8(18)6-23-14/h2-6,13H,7H2,1H3,(H2,22,25)(H,24,26)/t13-,17+/m0/s1	FKVYNLQDLMIRRO-SUMWQHHRSA-N	124134	US8754075, 3	Beta-secretase 2			 7						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124134&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66557906	225150526							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253272	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C18H15F2N5O2/c1-18(15(20)9-27-17(22)25-18)12-6-11(3-4-13(12)19)24-16(26)14-5-2-10(7-21)8-23-14/h2-6,8,15H,9H2,1H3,(H2,22,25)(H,24,26)/t15-,18+/m0/s1	ALKHFUPBQSAGMS-MAUKXSAKSA-N	50432608	CHEMBL2347204::US8754075, 4	Beta-secretase 2			 21						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432608&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	1H7	4J0V	66558601	164161483		CHEMBL2347204				ZINC95604687	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253273	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C18H17F3N4O3/c1-18(15(21)8-27-17(22)25-18)12-6-10(2-4-13(12)20)24-16(26)14-5-3-11(7-23-14)28-9-19/h2-7,15H,8-9H2,1H3,(H2,22,25)(H,24,26)/t15-,18+/m0/s1	NTRJCURAORAYRG-MAUKXSAKSA-N	124135	US8754075, 5	Beta-secretase 2			 106						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124135&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558602	225150527							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253274	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C18H14ClF2N5O2/c1-18(14(21)8-28-17(23)26-18)11-5-10(2-3-13(11)20)25-16(27)15-12(19)4-9(6-22)7-24-15/h2-5,7,14H,8H2,1H3,(H2,23,26)(H,25,27)/t14-,18+/m0/s1	KYSGVAXATOXFCB-KBXCAEBGSA-N	124137	US8754075, 7	Beta-secretase 2			 10						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124137&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558604	225150529							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253275	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F	InChI=1S/C17H14ClF3N4O2/c1-17(13(21)7-27-16(22)25-17)10-5-9(2-3-11(10)19)24-15(26)14-12(20)4-8(18)6-23-14/h2-6,13H,7H2,1H3,(H2,22,25)(H,24,26)/t13-,17+/m0/s1	WGZWTJFBCUJEDS-SUMWQHHRSA-N	124138	US8754075, 8	Beta-secretase 2			 6						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124138&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558605	225150530							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253276	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C18H14ClF5N4O2/c1-17(13(21)7-30-16(25)28-17)10-5-9(2-3-12(10)20)27-15(29)14-11(19)4-8(6-26-14)18(22,23)24/h2-6,13H,7H2,1H3,(H2,25,28)(H,27,29)/t13-,17+/m0/s1	PUZPTNAELKFHSA-SUMWQHHRSA-N	124139	US8754075, 9	Beta-secretase 2			 124						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124139&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558686	225150531							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253277	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(cn2)C(F)F)ccc1F	InChI=1S/C18H16F4N4O2/c1-18(14(20)8-28-17(23)26-18)11-6-10(3-4-12(11)19)25-16(27)13-5-2-9(7-24-13)15(21)22/h2-7,14-15H,8H2,1H3,(H2,23,26)(H,25,27)/t14-,18+/m0/s1	IJKRHLSQOCWFJH-KBXCAEBGSA-N	124141	US8754075, 11	Beta-secretase 2			 1						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124141&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558688	225150533							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253278	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OC[C@@H]1F	InChI=1S/C18H18F2N4O3/c1-18(15(20)9-27-17(21)24-18)12-7-10(3-5-13(12)19)23-16(25)14-6-4-11(26-2)8-22-14/h3-8,15H,9H2,1-2H3,(H2,21,24)(H,23,25)/t15-,18+/m0/s1	VVMUTCSDIWXUCG-MAUKXSAKSA-N	124143	US8754075, 13	Beta-secretase 2			 65						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124143&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558690	225150535							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253279	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(cn2)C#CC2CC2)ccc1F	InChI=1S/C22H20F2N4O2/c1-22(19(24)12-30-21(25)28-22)16-10-15(7-8-17(16)23)27-20(29)18-9-6-14(11-26-18)5-4-13-2-3-13/h6-11,13,19H,2-3,12H2,1H3,(H2,25,28)(H,27,29)/t19-,22+/m0/s1	JIXCAGUAYBCKGM-SIKLNZKXSA-N	124144	US8754075, 14	Beta-secretase 2			 9						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124144&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558691	225150536							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253280	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F	InChI=1S/C17H15F4N5O2/c1-17(13(19)7-28-16(22)26-17)9-4-8(2-3-10(9)18)25-15(27)12-6-23-11(5-24-12)14(20)21/h2-6,13-14H,7H2,1H3,(H2,22,26)(H,25,27)/t13-,17+/m0/s1	BJYCZMRWVCPZKH-SUMWQHHRSA-N	124145	US8754075, 15	Beta-secretase 2			 23						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124145&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558771	225150537							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253281	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2cnc(OCC3CC3)cn2)ccc1F	InChI=1S/C20H21F2N5O3/c1-20(16(22)10-30-19(23)27-20)13-6-12(4-5-14(13)21)26-18(28)15-7-25-17(8-24-15)29-9-11-2-3-11/h4-8,11,16H,2-3,9-10H2,1H3,(H2,23,27)(H,26,28)/t16-,20+/m0/s1	PSZVESJICQKTRE-OXJNMPFZSA-N	124146	US8754075, 16	Beta-secretase 2			 590						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124146&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558772	225150538							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253282	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C19H17F5N4O3/c1-18(15(21)8-30-17(25)28-18)12-6-10(2-4-13(12)20)27-16(29)14-5-3-11(7-26-14)31-9-19(22,23)24/h2-7,15H,8-9H2,1H3,(H2,25,28)(H,27,29)/t15-,18+/m0/s1	LUQWHFMXIMHIHJ-MAUKXSAKSA-N	124147	US8754075, 17	Beta-secretase 2			 2300						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124147&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559098	225150539							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253283	Cc1cc(C(=O)Nc2ccc(F)c(c2)[C@@]2(C)N=C(N)OC[C@@H]2F)c(C)o1	InChI=1S/C18H19F2N3O3/c1-9-6-12(10(2)26-9)16(24)22-11-4-5-14(19)13(7-11)18(3)15(20)8-25-17(21)23-18/h4-7,15H,8H2,1-3H3,(H2,21,23)(H,22,24)/t15-,18+/m0/s1	OHCOXMADQMWRFQ-MAUKXSAKSA-N	124148	US8754075, 18	Beta-secretase 2			 20						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124148&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559189	225150540							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253284	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H15F3N4O2/c1-17(14(20)8-26-16(21)24-17)11-6-10(3-4-12(11)19)23-15(25)13-5-2-9(18)7-22-13/h2-7,14H,8H2,1H3,(H2,21,24)(H,23,25)/t14-,17+/m0/s1	FKDTZPRHWANBCA-WMLDXEAASA-N	124150	US8754075, 20	Beta-secretase 2			 7						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124150&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558773	225150542							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253285	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2ccc(cn2)C2CC2)ccc1F	InChI=1S/C20H20F2N4O2/c1-20(17(22)10-28-19(23)26-20)14-8-13(5-6-15(14)21)25-18(27)16-7-4-12(9-24-16)11-2-3-11/h4-9,11,17H,2-3,10H2,1H3,(H2,23,26)(H,25,27)/t17-,20+/m0/s1	WTSAKQHAGKRFAQ-FXAWDEMLSA-N	124152	US8754075, 22	Beta-secretase 2			 124						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124152&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558774	225150544							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253286	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2cnc(Cl)s2)ccc1F	InChI=1S/C15H13ClF2N4O2S/c1-15(11(18)6-24-14(19)22-15)8-4-7(2-3-9(8)17)21-12(23)10-5-20-13(16)25-10/h2-5,11H,6H2,1H3,(H2,19,22)(H,21,23)/t11-,15+/m0/s1	VVDUWXONJNQSOT-XHDPSFHLSA-N	124156	US8754075, 26	Beta-secretase 2			 1405						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124156&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558776	225150548							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253287	Cn1nc(cc1C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OC[C@@H]1F)C(F)(F)F	InChI=1S/C17H16F5N5O2/c1-16(12(19)7-29-15(23)25-16)9-5-8(3-4-10(9)18)24-14(28)11-6-13(17(20,21)22)26-27(11)2/h3-6,12H,7H2,1-2H3,(H2,23,25)(H,24,28)/t12-,16+/m0/s1	PONYCQGFYCIYRU-BLLLJJGKSA-N	124157	US8754075, 27	Beta-secretase 2			 709						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124157&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558854	225150549							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253288	C[C@@]1(N=C(N)OC[C@@H]1F)c1cc(NC(=O)c2[nH]ncc2Cl)ccc1F	InChI=1S/C15H14ClF2N5O2/c1-15(11(18)6-25-14(19)22-15)8-4-7(2-3-10(8)17)21-13(24)12-9(16)5-20-23-12/h2-5,11H,6H2,1H3,(H2,19,22)(H,20,23)(H,21,24)/t11-,15+/m0/s1	DSOVCCKHSOQORN-XHDPSFHLSA-N	124158	US8754075, 28	Beta-secretase 2			 35						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124158&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558856	225150550							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253289	C[C@@]1(N=C(N)OC[C@H]1F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C18H15F2N5O2/c1-18(15(20)9-27-17(22)25-18)12-6-11(3-4-13(12)19)24-16(26)14-5-2-10(7-21)8-23-14/h2-6,8,15H,9H2,1H3,(H2,22,25)(H,24,26)/t15-,18-/m1/s1	ALKHFUPBQSAGMS-CRAIPNDOSA-N	50432607	CHEMBL2347205::US8754075, 33	Beta-secretase 2			 1174						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432607&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	1H6	4J0Y	66558858	164161482		CHEMBL2347205				ZINC95601492	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253290	C[C@@]1(N=C(N)OC[C@H]1F)c1cc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C18H14ClF2N5O2/c1-18(14(21)8-28-17(23)26-18)11-5-10(2-3-13(11)20)25-16(27)15-12(19)4-9(6-22)7-24-15/h2-5,7,14H,8H2,1H3,(H2,23,26)(H,25,27)/t14-,18-/m1/s1	KYSGVAXATOXFCB-RDTXWAMCSA-N	124164	US8754075, 35	Beta-secretase 2			 511						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124164&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558860	225150556							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253291	C[C@@]1(N=C(N)OC[C@H]1F)c1cc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C18H14ClF5N4O2/c1-17(13(21)7-30-16(25)28-17)10-5-9(2-3-12(10)20)27-15(29)14-11(19)4-8(6-26-14)18(22,23)24/h2-6,13H,7H2,1H3,(H2,25,28)(H,27,29)/t13-,17-/m1/s1	PUZPTNAELKFHSA-CXAGYDPISA-N	124165	US8754075, 36	Beta-secretase 2			 4029						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124165&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558932	225150557							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253292	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ncccc2OCC(F)(F)F)ccc1F	InChI=1S/C20H19F5N4O3/c1-18(22)9-32-17(26)29-19(18,2)12-8-11(5-6-13(12)21)28-16(30)15-14(4-3-7-27-15)31-10-20(23,24)25/h3-8H,9-10H2,1-2H3,(H2,26,29)(H,28,30)/t18-,19+/m0/s1	WAGVRKPPJOWFFS-RBUKOAKNSA-N	124166	US8754075, 37	Beta-secretase 2			 226						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124166&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559099	225150558							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253293	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H17F2N5O2/c1-18(21)10-28-17(23)26-19(18,2)13-7-12(4-5-14(13)20)25-16(27)15-6-3-11(8-22)9-24-15/h3-7,9H,10H2,1-2H3,(H2,23,26)(H,25,27)/t18-,19+/m0/s1	GNZDJABHDPTECH-RBUKOAKNSA-N	124167	US8754075, 38	Beta-secretase 2			 23						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124167&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558933	225150559							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253294	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C18H16Cl2F2N4O2/c1-17(22)8-28-16(23)26-18(17,2)11-6-10(3-4-13(11)21)25-15(27)14-12(20)5-9(19)7-24-14/h3-7H,8H2,1-2H3,(H2,23,26)(H,25,27)/t17-,18+/m0/s1	NZASLBMMFRPVKI-ZWKOTPCHSA-N	124168	US8754075, 39	Beta-secretase 2			 4						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124168&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66557907	225150560							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253295	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C17H16ClF4N5O2/c1-16(22)7-29-15(23)25-17(16,2)9-5-8(3-4-11(9)19)24-13(28)12-10(18)6-27(26-12)14(20)21/h3-6,14H,7H2,1-2H3,(H2,23,25)(H,24,28)/t16-,17+/m0/s1	WTHOIYZCRWOJGP-DLBZAZTESA-N	124169	US8754075, 40	Beta-secretase 2			 31						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124169&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558934	225150561							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253296	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H17ClF2N4O2/c1-17(21)9-27-16(22)25-18(17,2)12-7-11(4-5-13(12)20)24-15(26)14-6-3-10(19)8-23-14/h3-8H,9H2,1-2H3,(H2,22,25)(H,24,26)/t17-,18+/m0/s1	NPMZPSZAYDDDQG-ZWKOTPCHSA-N	124170	US8754075, 41	Beta-secretase 2			 6						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124170&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558935	225150562							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253297	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H17F3N4O2/c1-17(21)9-27-16(22)25-18(17,2)12-7-11(4-5-13(12)20)24-15(26)14-6-3-10(19)8-23-14/h3-8H,9H2,1-2H3,(H2,22,25)(H,24,26)/t17-,18+/m0/s1	NVOQNXJHOVMVBJ-ZWKOTPCHSA-N	124171	US8754075, 42	Beta-secretase 2			 74						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124171&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66558936	225150563							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253298	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2nn(CC(F)F)cc2Cl)ccc1F	InChI=1S/C18H18ClF4N5O2/c1-17(23)8-30-16(24)26-18(17,2)10-5-9(3-4-12(10)20)25-15(29)14-11(19)6-28(27-14)7-13(21)22/h3-6,13H,7-8H2,1-2H3,(H2,24,26)(H,25,29)/t17-,18+/m0/s1	FFTNLDBKNPISTD-ZWKOTPCHSA-N	124172	US8754075, 43	Beta-secretase 2			 110						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124172&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559187	225150564							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253299	C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)C2CC2(F)F)ccc1F	InChI=1S/C16H17F4N3O2/c1-14(18)7-25-13(21)23-15(14,2)9-5-8(3-4-11(9)17)22-12(24)10-6-16(10,19)20/h3-5,10H,6-7H2,1-2H3,(H2,21,23)(H,22,24)/t10?,14-,15+/m0/s1	PUJNNEOQOMQHHE-XVDHHWJWSA-N	124173	US8754075, 44	Beta-secretase 2			 140						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124173&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559188	225150565							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253300	C[C@@]1(N=C(N)OC[C@@H]1OCC(F)(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H17ClF4N4O3/c1-18(15(8-30-17(25)28-18)31-9-19(22,23)24)12-6-11(3-4-13(12)21)27-16(29)14-5-2-10(20)7-26-14/h2-7,15H,8-9H2,1H3,(H2,25,28)(H,27,29)/t15-,18+/m0/s1	OILODYURZOTHSC-MAUKXSAKSA-N	124174	US8754075, 45	Beta-secretase 2			 61						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124174&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559013	225150566							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253301	C[C@@]1(N=C(N)OC[C@@H]1OCC(F)(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H17F5N4O3/c1-18(15(8-30-17(25)28-18)31-9-19(22,23)24)12-6-11(3-4-13(12)21)27-16(29)14-5-2-10(20)7-26-14/h2-7,15H,8-9H2,1H3,(H2,25,28)(H,27,29)/t15-,18+/m0/s1	LTPGAOLCDJJIPI-MAUKXSAKSA-N	124175	US8754075, 46	Beta-secretase 2			 65						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124175&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559014	225150567							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253302	C[C@@]1(N=C(N)OC[C@@H]1OCC(F)(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H17F4N5O3/c1-19(16(9-31-18(26)29-19)32-10-20(22,23)24)13-6-12(3-4-14(13)21)28-17(30)15-5-2-11(7-25)8-27-15/h2-6,8,16H,9-10H2,1H3,(H2,26,29)(H,28,30)/t16-,19+/m0/s1	FVAAHYRLUYIRSN-QFBILLFUSA-N	124176	US8754075, 47	Beta-secretase 2			 268						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124176&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66559015	225150568							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
253303	C[C@@]1(N=C(N)OC[C@@H]1OCC(F)(F)F)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C19H16Cl2F4N4O3/c1-18(14(7-31-17(26)29-18)32-8-19(23,24)25)11-5-10(2-3-13(11)22)28-16(30)15-12(21)4-9(20)6-27-15/h2-6,14H,7-8H2,1H3,(H2,26,29)(H,28,30)/t14-,18+/m0/s1	RNACDDOYNBSODP-KBXCAEBGSA-N	124177	US8754075, 48	Beta-secretase 2			 67						37.00 C	US Patent		10.7270/Q2FX784Q		aid1800510	US8754075	Hilpert, H; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124177&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66557908	225150569							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261970	COc1ccc(Cl)cc1Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)N(C)C(=O)C1(C)C	InChI=1S/C21H24ClFN4O2/c1-20(2)18(28)27(4)19(24)26-21(20,3)14-11-13(7-8-15(14)23)25-16-10-12(22)6-9-17(16)29-5/h6-11,25H,1-5H3,(H2,24,26)/t21-/m1/s1	BXEJTNMVGGAFEN-OAQYLSRUSA-N	130215	US8815881, 150	Beta-secretase 2			 21						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130215&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497043	225156550							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261971	CC(C)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)N(C)C(=O)C1(C)C	InChI=1S/C18H25FN4O2/c1-10(2)14(24)21-11-7-8-13(19)12(9-11)18(5)17(3,4)15(25)23(6)16(20)22-18/h7-10H,1-6H3,(H2,20,22)(H,21,24)/t18-/m1/s1	OEUSFIMFURPYBJ-GOSISDBHSA-N	130216	US8815881, 151	Beta-secretase 2			 100						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130216&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727564	225156551							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261972	CN1C(N)=N[C@](C)(c2cc(Nc3ccc(cc3)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C21H22FN5O/c1-20(2)18(28)27(4)19(24)26-21(20,3)16-11-15(9-10-17(16)22)25-14-7-5-13(12-23)6-8-14/h5-11,25H,1-4H3,(H2,24,26)/t21-/m1/s1	RGDDXRTUMSIBKJ-OAQYLSRUSA-N	130217	US8815881, 153	Beta-secretase 2			 130						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130217&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727497	225156552							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261973	COc1cc(Cl)c(C)cc1Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)N(C)C(=O)C1(C)C	InChI=1S/C22H26ClFN4O2/c1-12-9-17(18(30-6)11-15(12)23)26-13-7-8-16(24)14(10-13)22(4)21(2,3)19(29)28(5)20(25)27-22/h7-11,26H,1-6H3,(H2,25,27)/t22-/m1/s1	XAVGSXNEPBAWAX-JOCHJYFZSA-N	130218	US8815881, 154	Beta-secretase 2			 35						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497042	225156553							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261974	CN1C(N)=N[C@](C)(c2cc(Nc3ccc(cc3OC(F)(F)F)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C22H21F4N5O2/c1-20(2)18(32)31(4)19(28)30-21(20,3)14-10-13(6-7-15(14)23)29-16-8-5-12(11-27)9-17(16)33-22(24,25)26/h5-10,29H,1-4H3,(H2,28,30)/t21-/m1/s1	LVOJRTFUMCPUIR-OAQYLSRUSA-N	130199	US8815881, 161	Beta-secretase 2			 13						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130199&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727734	225156534							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261975	CN1C(N)=N[C@](C)(c2cc(NC3CCCC3C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C20H26FN5O/c1-19(2)17(27)26(4)18(23)25-20(19,3)14-10-13(8-9-15(14)21)24-16-7-5-6-12(16)11-22/h8-10,12,16,24H,5-7H2,1-4H3,(H2,23,25)/t12?,16?,20-/m1/s1	NWIKYHDOXQYHFA-QRGKXYNMSA-N	130200	US8815881, 162	Beta-secretase 2			 120						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130200&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56649992	225156535							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261976	CN1C(N)=NC(C)(c2cc(Nc3ccc(cc3C(F)(F)F)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C22H21F4N5O/c1-20(2)18(32)31(4)19(28)30-21(20,3)14-10-13(6-7-16(14)23)29-17-8-5-12(11-27)9-15(17)22(24,25)26/h5-10,29H,1-4H3,(H2,28,30)	ZLVJZYYAWCAHNK-UHFFFAOYSA-N	130201	US8815881, 163	Beta-secretase 2			 62						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130201&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497101	225156536							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261977	CN1C(N)=NC(C)(c2cc(Nc3ccc(C)cc3)ccc2F)C(C)(C)C1=O	InChI=1S/C21H25FN4O/c1-13-6-8-14(9-7-13)24-15-10-11-17(22)16(12-15)21(4)20(2,3)18(27)26(5)19(23)25-21/h6-12,24H,1-5H3,(H2,23,25)	LRCKYYWVNDOFGU-UHFFFAOYSA-N	130202	US8815881, 164	Beta-secretase 2			 1090						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130202&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727561	225156537							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261978	CN1C(N)=N[C@](C)(c2cc(Nc3cc(ccc3F)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C21H21F2N5O/c1-20(2)18(29)28(4)19(25)27-21(20,3)14-10-13(6-8-15(14)22)26-17-9-12(11-24)5-7-16(17)23/h5-10,26H,1-4H3,(H2,25,27)/t21-/m1/s1	RPSZAZWPEGFBRO-OAQYLSRUSA-N	130203	US8815881, 165	Beta-secretase 2			 39						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130203&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727454	225156538							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261979	CN1C(N)=N[C@](C)(c2cc(Nc3cc(F)c(cc3F)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C21H20F3N5O/c1-20(2)18(30)29(4)19(26)28-21(20,3)13-8-12(5-6-14(13)22)27-17-9-15(23)11(10-25)7-16(17)24/h5-9,27H,1-4H3,(H2,26,28)/t21-/m1/s1	QKDQGCFCVYWBCV-OAQYLSRUSA-N	130204	US8815881, 166	Beta-secretase 2			 80						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130204&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727633	225156539							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261980	CN1C(N)=N[C@](C)(c2cc(Nc3cccc(c3)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C21H22FN5O/c1-20(2)18(28)27(4)19(24)26-21(20,3)16-11-15(8-9-17(16)22)25-14-7-5-6-13(10-14)12-23/h5-11,25H,1-4H3,(H2,24,26)/t21-/m1/s1	SUOXQELZQZJXPN-OAQYLSRUSA-N	130205	US8815881, 167	Beta-secretase 2			 73						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130205&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57516125	225156540							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261981	CN1C(N)=N[C@](C)(c2cc(Nc3ccc(cc3Cl)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C21H21ClFN5O/c1-20(2)18(29)28(4)19(25)27-21(20,3)14-10-13(6-7-16(14)23)26-17-8-5-12(11-24)9-15(17)22/h5-10,26H,1-4H3,(H2,25,27)/t21-/m1/s1	VCMRXCPXJUVWAY-OAQYLSRUSA-N	130206	US8815881, 168	Beta-secretase 2			 14						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130206&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57516126	225156541							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261982	CN1C(N)=N[C@](C)(c2cc(Nc3ccc(C)c(c3)C#N)ccc2F)C(C)(C)C1=O	InChI=1S/C22H24FN5O/c1-13-6-7-15(10-14(13)12-24)26-16-8-9-18(23)17(11-16)22(4)21(2,3)19(29)28(5)20(25)27-22/h6-11,26H,1-5H3,(H2,25,27)/t22-/m1/s1	UHPCFZPNNHTWSB-JOCHJYFZSA-N	130207	US8815881, 169	Beta-secretase 2			 180						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130207&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57516127	225156542							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261983	COc1ccc(Nc2ccc(F)c(c2)C2(C)N=C(N)N(C)C(=O)C2(C)C)cn1	InChI=1S/C20H24FN5O2/c1-19(2)17(27)26(4)18(22)25-20(19,3)14-10-12(6-8-15(14)21)24-13-7-9-16(28-5)23-11-13/h6-11,24H,1-5H3,(H2,22,25)	FCFZJECWFCAWSP-UHFFFAOYSA-N	130208	US8815881, 170	Beta-secretase 2			 140						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130208&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727580	225156543							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261984	CN1C(N)=N[C@](C)(c2cc(Nc3ccc(C)nc3)ccc2F)C(C)(C)C1=O	InChI=1S/C20H24FN5O/c1-12-6-7-14(11-23-12)24-13-8-9-16(21)15(10-13)20(4)19(2,3)17(27)26(5)18(22)25-20/h6-11,24H,1-5H3,(H2,22,25)/t20-/m1/s1	JMTUUCQFHFIXQP-HXUWFJFHSA-N	130209	US8815881, 171	Beta-secretase 2			 1800						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130209&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497028	225156544							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261985	CN1C(N)=NC(C)(c2cc(Nc3ccc(OCC(F)(F)F)nc3)ccc2F)C(C)(C)C1=O	InChI=1S/C21H23F4N5O2/c1-19(2)17(31)30(4)18(26)29-20(19,3)14-9-12(5-7-15(14)22)28-13-6-8-16(27-10-13)32-11-21(23,24)25/h5-10,28H,11H2,1-4H3,(H2,26,29)	NXPOBAAAVKDOEM-UHFFFAOYSA-N	130210	US8815881, 172	Beta-secretase 2			 110						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130210&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66727732	225156545							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261986	CN1C(N)=N[C@](C)(c2cc(Nc3ccc(nc3)C(F)(F)F)ccc2F)C(C)(C)C1=O	InChI=1S/C20H21F4N5O/c1-18(2)16(30)29(4)17(25)28-19(18,3)13-9-11(5-7-14(13)21)27-12-6-8-15(26-10-12)20(22,23)24/h5-10,27H,1-4H3,(H2,25,28)/t19-/m1/s1	KUJOFLZJLRFNEG-LJQANCHMSA-N	130211	US8815881, 173	Beta-secretase 2			 400						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130211&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497026	225156546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261987	CN1C(N)=N[C@](C)(c2cc(Nc3cncc(F)c3)ccc2F)C(C)(C)C1=O	InChI=1S/C19H21F2N5O/c1-18(2)16(27)26(4)17(22)25-19(18,3)14-8-12(5-6-15(14)21)24-13-7-11(20)9-23-10-13/h5-10,24H,1-4H3,(H2,22,25)/t19-/m1/s1	UXZQTODWYSJNTM-LJQANCHMSA-N	130212	US8815881, 174	Beta-secretase 2			 150						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130212&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497024	225156547							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261988	CN1C(N)=N[C@](C)(c2cc(Nc3cncc(c3)C(F)(F)F)ccc2F)C(C)(C)C1=O	InChI=1S/C20H21F4N5O/c1-18(2)16(30)29(4)17(25)28-19(18,3)14-8-12(5-6-15(14)21)27-13-7-11(9-26-10-13)20(22,23)24/h5-10,27H,1-4H3,(H2,25,28)/t19-/m1/s1	XVHKCMUPKSKCMO-LJQANCHMSA-N	130213	US8815881, 175	Beta-secretase 2			 250						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130213&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497022	225156548							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
261989	CN1C(N)=N[C@](C)(c2cc(Nc3ccc(Cl)nc3)ccc2F)C(C)(C)C1=O	InChI=1S/C19H21ClFN5O/c1-18(2)16(27)26(4)17(22)25-19(18,3)13-9-11(5-7-14(13)21)24-12-6-8-15(20)23-10-12/h5-10,24H,1-4H3,(H2,22,25)/t19-/m1/s1	RTRKUSOLOVUGEL-LJQANCHMSA-N	130214	US8815881, 176	Beta-secretase 2			 130						4.00 C	US Patent		10.7270/Q2NZ86B5		aid1800629	US8815881	Banner, D; Gabellieri, E; Guba, W; Hilpert, H; Hornsperger, B; Humm, R; Mauser, H; Mayweg, AV; Narquizian, R; Pinard, E; Rogers-Evans, M; Woltering, T; Wostl, W	Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130214&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57497045	225156549							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279442	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H17ClFN5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	VBWPFVMZZPWFMD-KRWDZBQOSA-N	143218	US8940748, 34::US9029362, 34::US9687494, 34	Beta-secretase 2		 0.22						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51039270	251971813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279443	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C18H17F4N5O3S/c1-17(9-31(29,30)27(2)16(23)26-17)12-7-11(4-5-13(12)19)25-15(28)14-6-3-10(8-24-14)18(20,21)22/h3-8H,9H2,1-2H3,(H2,23,26)(H,25,28)/t17-/m0/s1	XBJQDMHXDUQMJV-KRWDZBQOSA-N	143219	US8940748, 26::US9029362, 26::US9687494, 26	Beta-secretase 2		 2.46						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143219&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111677	251971814							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279444	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	YHYKUSGACIYRML-KRWDZBQOSA-N	47353	BDBM143220::US9029362, 173::US9687494, 25	Beta-secretase 2		 0.37						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47353&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			1484169	24824350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279445	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2cnc(C)cn2)ccc1F	InChI=1S/C17H19FN6O3S/c1-10-7-21-14(8-20-10)15(25)22-11-4-5-13(18)12(6-11)17(2)9-28(26,27)24(3)16(19)23-17/h4-8H,9H2,1-3H3,(H2,19,23)(H,22,25)/t17-/m0/s1	QEDBRPQZTWTMTK-KRWDZBQOSA-N	143221	US8940748, 36::US9029362, 36::US9687494, 36	Beta-secretase 2		 4.85						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51352402	251971816							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279446	COc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H18F2N6O4S/c1-17(8-30(27,28)25(2)16(20)24-17)10-4-9(5-11(18)14(10)19)23-15(26)12-6-22-13(29-3)7-21-12/h4-7H,8H2,1-3H3,(H2,20,24)(H,23,26)/t17-/m0/s1	QGPBROSNFKNVFL-KRWDZBQOSA-N	143222	US8940748, 40di::US9029362, 40di::US9687494, 40di	Beta-secretase 2		 2.15						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143222&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111419	251971817							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279447	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(C)cn2)ccc1F	InChI=1S/C18H20FN5O3S/c1-11-4-7-15(21-9-11)16(25)22-12-5-6-14(19)13(8-12)18(2)10-28(26,27)24(3)17(20)23-18/h4-9H,10H2,1-3H3,(H2,20,23)(H,22,25)/t18-/m0/s1	LWWIOJQKELULTO-SFHVURJKSA-N	143223	US8940748, 35::US9029362, 35::US9687494, 35	Beta-secretase 2		 0.45						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111335	251971818							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279448	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(NC(=O)c2ccc(F)cn2)c1F	InChI=1S/C17H16F3N5O3S/c1-17(8-29(27,28)25(2)16(21)24-17)13-10(19)4-6-11(14(13)20)23-15(26)12-5-3-9(18)7-22-12/h3-7H,8H2,1-2H3,(H2,21,24)(H,23,26)/t17-/m0/s1	VXLAYHUGSSZHSG-KRWDZBQOSA-N	143224	US8940748, 173::US9687494, 173	Beta-secretase 2		 0.47						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143224&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111673	251971819							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279449	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(cs1)-c1ccc(F)c(c1)C#N	InChI=1S/C16H15FN4O2S2/c1-16(9-25(22,23)21(2)15(19)20-16)14-6-12(8-24-14)10-3-4-13(17)11(5-10)7-18/h3-6,8H,9H2,1-2H3,(H2,19,20)/t16-/m0/s1	BRXXBTMKBTXEJJ-INIZCTEOSA-N	143226	US8940748, 46::US9029362, 46::US9687494, 46	Beta-secretase 2		 8.23						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143226&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111513	251971821							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279450	CC#Cc1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H17ClN4O2S2/c1-4-5-11-6-12(9-20-8-11)14-7-13(18)15(25-14)17(2)10-26(23,24)22(3)16(19)21-17/h6-9H,10H2,1-3H3,(H2,19,21)/t17-/m0/s1	VKVMIZCLMUKTTA-KRWDZBQOSA-N	143227	US8940748, 52::US9029362, 52::US9687494, 52	Beta-secretase 2		 0.37						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	66J	5HTZ	68111516	251971822							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
279451	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H19FN6O4S/c1-17(9-29(26,27)24(2)16(19)23-17)11-6-10(4-5-12(11)18)22-15(25)13-7-21-14(28-3)8-20-13/h4-8H,9H2,1-3H3,(H2,19,23)(H,22,25)/t17-/m0/s1	DJIXTIKKTNRBEW-KRWDZBQOSA-N	143228	US8940748, 40ai::US9029362, 40ai::US9687494, 40ai	Beta-secretase 2		 1.99						5	30.00 C	US Patent		10.7270/Q2ZC81MM		aid1800874	US8940748	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111681	251971823							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286520	NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncco1)c1ccc(F)cc1F	InChI=1S/C16H15F2N3O2S/c17-10-1-2-11(12(18)6-10)16-8-23-13(14-20-3-4-22-14)5-9(16)7-24-15(19)21-16/h1-4,6,9,13H,5,7-8H2,(H2,19,21)/t9-,13+,16-/m0/s1	ITDPHYUDGLCWQU-VAHXTSCQSA-N	148173	US8962616, 1	Beta-secretase 2			 619					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148173&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547065	252109061							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286521	Cn1ccc(n1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H18F2N4OS/c1-23-5-4-14(22-23)15-6-10-8-25-16(20)21-17(10,9-24-15)12-3-2-11(18)7-13(12)19/h2-5,7,10,15H,6,8-9H2,1H3,(H2,20,21)/t10-,15+,17-/m0/s1	KCRIWCAXODSLRH-FGDXXIHYSA-N	148174	US8962616, 2	Beta-secretase 2			 4740					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148174&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547318	252109062							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286522	C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1nc(C)co1)c1ccc(F)cc1F	InChI=1S/C18H19F2N3O2S/c1-9-7-24-16(22-9)15-6-13-10(2)26-17(21)23-18(13,8-25-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	OAFBAMRSEZLVDJ-CKMNQQOVSA-N	148176	US8962616, 22::US8962616, 4	Beta-secretase 2			 273					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148176&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547070	252109064							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286523	C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1ncc(C)o1)c1ccc(F)cc1F	InChI=1S/C18H19F2N3O2S/c1-9-7-22-16(25-9)15-6-13-10(2)26-17(21)23-18(13,8-24-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	MUANLMPXGYYLAD-CKMNQQOVSA-N	148177	US8962616, 5	Beta-secretase 2			 1150					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148177&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819727	252109065							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286524	C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1ncco1)c1ccc(F)cc1F	InChI=1S/C17H17F2N3O2S/c1-9-12-7-14(15-21-4-5-23-15)24-8-17(12,22-16(20)25-9)11-3-2-10(18)6-13(11)19/h2-6,9,12,14H,7-8H2,1H3,(H2,20,22)/t9-,12+,14-,17-/m1/s1	UVLZAXVMVHTAGW-XMEITWMYSA-N	148178	US8962616, 6	Beta-secretase 2			 2370					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148178&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547068	252109066							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286525	CC1N=CC(=N1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H18F2N4OS/c1-9-21-6-14(22-9)15-4-10-7-25-16(20)23-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,9-10,15H,4,7-8H2,1H3,(H2,20,23)/t9?,10?,15-,17+/m1/s1	SGHCLOBTFNZTBO-HYSQSQNJSA-N	148179	US8962616, 7	Beta-secretase 2			 185					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148179&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819728	252109067							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286526	Cc1csc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H17F2N3OS2/c1-9-6-24-15(21-9)14-4-10-7-25-16(20)22-17(10,8-23-14)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,14H,4,7-8H2,1H3,(H2,20,22)/t10?,14-,17+/m1/s1	CTLGKGNBFWVQKZ-WETSXSAHSA-N	148180	US8962616, 8	Beta-secretase 2			 9720					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148180&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819729	252109068							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286527	Cc1nccc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C18H18F2N4OS/c1-10-22-5-4-15(23-10)16-6-11-8-26-17(21)24-18(11,9-25-16)13-3-2-12(19)7-14(13)20/h2-5,7,11,16H,6,8-9H2,1H3,(H2,21,24)/t11?,16-,18+/m1/s1	NCFZOHVZLVQZGK-APTIMPFDSA-N	148181	US8962616, 9	Beta-secretase 2			>100000					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148181&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819730	252109069							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286528	Cc1nc(co1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H17F2N3O2S/c1-9-21-14(6-23-9)15-4-10-7-25-16(20)22-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,15H,4,7-8H2,1H3,(H2,20,22)/t10?,15-,17+/m1/s1	XXLOHULFDLSOBC-KTITXKAJSA-N	148182	US8962616, 11	Beta-secretase 2			 2020					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148182&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819731	252109070							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286529	Cc1noc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C16H16F2N4O2S/c1-8-20-14(24-22-8)13-4-9-6-25-15(19)21-16(9,7-23-13)11-3-2-10(17)5-12(11)18/h2-3,5,9,13H,4,6-7H2,1H3,(H2,19,21)/t9?,13-,16+/m1/s1	OCCFWRRDRBBZBE-ZQQVQGEJSA-N	148185	US8962616, 13	Beta-secretase 2			 208					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148185&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819734	252109073							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286530	Cc1nc(oc1C)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C18H19F2N3O2S/c1-9-10(2)25-16(22-9)15-5-11-7-26-17(21)23-18(11,8-24-15)13-4-3-12(19)6-14(13)20/h3-4,6,11,15H,5,7-8H2,1-2H3,(H2,21,23)/t11?,15-,18+/m1/s1	ONVXCGHYMYSNTM-HLSDDEKHSA-N	148186	US8962616, 15	Beta-secretase 2			 2820					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148186&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819735	252109074							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286531	Cc1cc(on1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H17F2N3O2S/c1-9-4-15(24-22-9)14-5-10-7-25-16(20)21-17(10,8-23-14)12-3-2-11(18)6-13(12)19/h2-4,6,10,14H,5,7-8H2,1H3,(H2,20,21)/t10?,14-,17+/m1/s1	APXCHRRPLFZFMP-WETSXSAHSA-N	50012648	CHEMBL3261057	Beta-secretase 2			 4550					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012648	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012648&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90656187	103924901		CHEMBL3261057				ZINC29464389	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286532	Cc1nnc(o1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C16H16F2N4O2S/c1-8-21-22-14(24-8)13-4-9-6-25-15(19)20-16(9,7-23-13)11-3-2-10(17)5-12(11)18/h2-3,5,9,13H,4,6-7H2,1H3,(H2,19,20)/t9?,13-,16+/m1/s1	GPDCFLSYOJXISU-ZQQVQGEJSA-N	148172	US8962616, 17	Beta-secretase 2			 5560					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148172&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91819726	252109060							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286533	NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ccncn1)c1ccc(F)cc1F	InChI=1S/C17H16F2N4OS/c18-11-1-2-12(13(19)6-11)17-8-24-15(14-3-4-21-9-22-14)5-10(17)7-25-16(20)23-17/h1-4,6,9-10,15H,5,7-8H2,(H2,20,23)/t10-,15+,17-/m0/s1	RIDGBZAEKGYTQD-FGDXXIHYSA-N	148187	US8962616, 18	Beta-secretase 2			 695					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148187&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547574	252109075							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286534	NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1nc(co1)C(F)(F)F)c1ccc(F)cc1F	InChI=1S/C17H14F5N3O2S/c18-9-1-2-10(11(19)4-9)16-7-27-12(3-8(16)6-28-15(23)25-16)14-24-13(5-26-14)17(20,21)22/h1-2,4-5,8,12H,3,6-7H2,(H2,23,25)/t8-,12+,16-/m0/s1	UBFYFJQJWNNVJD-XLIXJNEVSA-N	148189	US8962616, 20	Beta-secretase 2			 629					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148189&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547069	252109077							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286535	NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncccn1)c1ccc(F)cc1F	InChI=1S/C17H16F2N4OS/c18-11-2-3-12(13(19)7-11)17-9-24-14(15-21-4-1-5-22-15)6-10(17)8-25-16(20)23-17/h1-5,7,10,14H,6,8-9H2,(H2,20,23)/t10-,14+,17-/m0/s1	ZMAAQEPRGLNYHJ-IXBGWNDUSA-N	148190	US8962616, 21	Beta-secretase 2			 3090					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148190&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547575	252109078							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286536	C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1nc(C)co1)c1ccc(F)cc1F	InChI=1S/C18H19F2N3O2S/c1-9-7-24-16(22-9)15-6-13-10(2)26-17(21)23-18(13,8-25-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	OAFBAMRSEZLVDJ-CKMNQQOVSA-N	148176	US8962616, 22::US8962616, 4	Beta-secretase 2			 1400					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148176&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72547070	252109064							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
286537	Cc1cnc(nc1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C18H18F2N4OS/c1-10-6-22-16(23-7-10)15-4-11-8-26-17(21)24-18(11,9-25-15)13-3-2-12(19)5-14(13)20/h2-3,5-7,11,15H,4,8-9H2,1H3,(H2,21,24)/t11-,15+,18-/m0/s1	SPUPFMFFTCRYOB-POHZPAGDSA-N	148193	US8962616, 24	Beta-secretase 2			 1080					4.5	37.00 C	US Patent		10.7270/Q20Z7216		aid1800938	US8962616	Brodney, MA; Butler, CR; Beck, EM; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148193&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72543978	252109080							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300579	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H17ClFN5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	VBWPFVMZZPWFMD-KRWDZBQOSA-N	143218	US8940748, 34::US9029362, 34::US9687494, 34	Beta-secretase 2		 0.22						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51039270	251971813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300580	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C18H17F4N5O3S/c1-17(9-31(29,30)27(2)16(23)26-17)12-7-11(4-5-13(12)19)25-15(28)14-6-3-10(8-24-14)18(20,21)22/h3-8H,9H2,1-2H3,(H2,23,26)(H,25,28)/t17-/m0/s1	XBJQDMHXDUQMJV-KRWDZBQOSA-N	143219	US8940748, 26::US9029362, 26::US9687494, 26	Beta-secretase 2		 2.46						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143219&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111677	251971814							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300581	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	YHYKUSGACIYRML-KRWDZBQOSA-N	47353	BDBM143220::US9029362, 173::US9687494, 25	Beta-secretase 2		 0.37						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47353&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			1484169	24824350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300582	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2cnc(C)cn2)ccc1F	InChI=1S/C17H19FN6O3S/c1-10-7-21-14(8-20-10)15(25)22-11-4-5-13(18)12(6-11)17(2)9-28(26,27)24(3)16(19)23-17/h4-8H,9H2,1-3H3,(H2,19,23)(H,22,25)/t17-/m0/s1	QEDBRPQZTWTMTK-KRWDZBQOSA-N	143221	US8940748, 36::US9029362, 36::US9687494, 36	Beta-secretase 2		 4.85						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51352402	251971816							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300583	COc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H18F2N6O4S/c1-17(8-30(27,28)25(2)16(20)24-17)10-4-9(5-11(18)14(10)19)23-15(26)12-6-22-13(29-3)7-21-12/h4-7H,8H2,1-3H3,(H2,20,24)(H,23,26)/t17-/m0/s1	QGPBROSNFKNVFL-KRWDZBQOSA-N	143222	US8940748, 40di::US9029362, 40di::US9687494, 40di	Beta-secretase 2		 2.15						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143222&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111419	251971817							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300584	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(C)cn2)ccc1F	InChI=1S/C18H20FN5O3S/c1-11-4-7-15(21-9-11)16(25)22-12-5-6-14(19)13(8-12)18(2)10-28(26,27)24(3)17(20)23-18/h4-9H,10H2,1-3H3,(H2,20,23)(H,22,25)/t18-/m0/s1	LWWIOJQKELULTO-SFHVURJKSA-N	143223	US8940748, 35::US9029362, 35::US9687494, 35	Beta-secretase 2		 0.45						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111335	251971818							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300585	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	YHYKUSGACIYRML-KRWDZBQOSA-N	47353	BDBM143220::US9029362, 173::US9687494, 25	Beta-secretase 2		 0.47						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47353&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			1484169	24824350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300586	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(cs1)-c1ccc(F)c(c1)C#N	InChI=1S/C16H15FN4O2S2/c1-16(9-25(22,23)21(2)15(19)20-16)14-6-12(8-24-14)10-3-4-13(17)11(5-10)7-18/h3-6,8H,9H2,1-2H3,(H2,19,20)/t16-/m0/s1	BRXXBTMKBTXEJJ-INIZCTEOSA-N	143226	US8940748, 46::US9029362, 46::US9687494, 46	Beta-secretase 2		 8.23						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143226&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111513	251971821							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300587	CC#Cc1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H17ClN4O2S2/c1-4-5-11-6-12(9-20-8-11)14-7-13(18)15(25-14)17(2)10-26(23,24)22(3)16(19)21-17/h6-9H,10H2,1-3H3,(H2,19,21)/t17-/m0/s1	VKVMIZCLMUKTTA-KRWDZBQOSA-N	143227	US8940748, 52::US9029362, 52::US9687494, 52	Beta-secretase 2		 0.37						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	66J	5HTZ	68111516	251971822							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
300588	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H19FN6O4S/c1-17(9-29(26,27)24(2)16(19)23-17)11-6-10(4-5-12(11)18)22-15(25)13-7-21-14(28-3)8-20-13/h4-8H,9H2,1-3H3,(H2,19,23)(H,22,25)/t17-/m0/s1	DJIXTIKKTNRBEW-KRWDZBQOSA-N	143228	US8940748, 40ai::US9029362, 40ai::US9687494, 40ai	Beta-secretase 2		 1.99						5	30.00 C	US Patent		10.7270/Q2X63KP6		aid1801222	US9029362	Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111681	251971823							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
303945	NC1=NC2(CO[C@@H](COCc3ccccc3)C[C@H]2CS1)c1cc(C#N)c(F)cc1F	InChI=1S/C22H21F2N3O2S/c23-19-8-20(24)18(6-15(19)9-25)22-13-29-17(7-16(22)12-30-21(26)27-22)11-28-10-14-4-2-1-3-5-14/h1-6,8,16-17H,7,10-13H2,(H2,26,27)/t16-,17+,22?/m0/s1	QWYYLSONPBZONE-NCHORFDRSA-N	160660	US9045498, 2	Beta-secretase 2			 2800					4.5	37.00 C	US Patent		10.7270/Q2W094PQ		aid1801277	US9045498	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160660&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90369176	295369476							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
303946	NC1=NC2(CO[C@@H](CF)C[C@H]2CS1)c1cc(C#N)c(F)cc1F	InChI=1S/C15H14F3N3OS/c16-4-10-2-9-6-23-14(20)21-15(9,7-22-10)11-1-8(5-19)12(17)3-13(11)18/h1,3,9-10H,2,4,6-7H2,(H2,20,21)/t9-,10+,15?/m0/s1	LGJIPDMTLWEFJV-TZPSPIKVSA-N	160662	US9045498, 4	Beta-secretase 2			 2520					4.5	37.00 C	US Patent		10.7270/Q2W094PQ		aid1801277	US9045498	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160662&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90369151	295369478							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
303947	NC1=N[C@]2(CO[C@@H](CF)C[C@H]2CS1)c1cc(CNCC(F)(F)F)ccc1F	InChI=1S/C17H20F5N3OS/c18-5-12-4-11-7-27-15(23)25-16(11,9-26-12)13-3-10(1-2-14(13)19)6-24-8-17(20,21)22/h1-3,11-12,24H,4-9H2,(H2,23,25)/t11-,12+,16-/m0/s1	YMEAVKLDFSPRMT-OZVIIMIRSA-N	160673	US9045498, 15	Beta-secretase 2			 423					4.5	37.00 C	US Patent		10.7270/Q2W094PQ		aid1801277	US9045498	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160673&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76281309	295369489							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
303948	Cn1cc(cn1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1cc(CNCC(F)(F)F)ccc1F	InChI=1S/C20H23F4N5OS/c1-29-8-13(7-27-29)17-5-14-9-31-18(25)28-19(14,11-30-17)15-4-12(2-3-16(15)21)6-26-10-20(22,23)24/h2-4,7-8,14,17,26H,5-6,9-11H2,1H3,(H2,25,28)/t14-,17+,19-/m0/s1	SFTSIIWRWYJDCO-YJLNNSPDSA-N	160674	US9045498, 16	Beta-secretase 2			 108					4.5	37.00 C	US Patent		10.7270/Q2W094PQ		aid1801277	US9045498	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160674	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160674&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74762656	295369490							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
303949	COC[C@@H](C)NCc1ccc(F)c(c1)[C@]12CO[C@H](C[C@H]1CSC(N)=N2)c1cnn(C)c1	InChI=1S/C22H30FN5O2S/c1-14(11-29-3)25-8-15-4-5-19(23)18(6-15)22-13-30-20(16-9-26-28(2)10-16)7-17(22)12-31-21(24)27-22/h4-6,9-10,14,17,20,25H,7-8,11-13H2,1-3H3,(H2,24,27)/t14-,17+,20-,22+/m1/s1	IAELCBCZISVJNJ-FKVUHXGFSA-N	160676	US9045498, 18	Beta-secretase 2			 20					4.5	37.00 C	US Patent		10.7270/Q2W094PQ		aid1801277	US9045498	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE; O'Neill, BT	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160676	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160676&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76281577	295369492							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
306769	CCOc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(N)n1	InChI=1S/C17H18F3N7O3/c1-3-29-10-6-23-11(13(21)26-10)14(28)25-9-5-4-8(18)12(24-9)16(2)17(19,20)7-30-15(22)27-16/h4-6H,3,7H2,1-2H3,(H2,21,26)(H2,22,27)(H,24,25,28)/t16-/m1/s1	NUEIKLHJDKPZGO-MRXNPFEDSA-N	60791	US9163011, 28	Beta-secretase 2			 10000					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60791&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121595828	317222848						ZINC03278792	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317714	CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C)cc(c1)C(=O)N(C)C(C)c1ccccc1)C(=O)NCC(C)C	InChI=1S/C38H52N4O5/c1-7-14-33(43)35(37(46)40-23-25(2)3)39-24-34(44)32(21-28-15-10-8-11-16-28)41-36(45)30-19-26(4)20-31(22-30)38(47)42(6)27(5)29-17-12-9-13-18-29/h8-13,15-20,22,25,27,32-35,39,43-44H,7,14,21,23-24H2,1-6H3,(H,40,46)(H,41,45)	SIJHZXLBPULCJF-UHFFFAOYSA-N	172740	US9096541, 113	Beta-secretase 2		 0.0014								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172740	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172740&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797801	312696751							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317715	CC(C)CNC(=O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C)cc(c1)C(=O)N(C)C(C)c1ccccc1)C(C)O	InChI=1S/C36H48N4O5/c1-23(2)21-38-35(44)33(26(5)41)37-22-32(42)31(19-27-13-9-7-10-14-27)39-34(43)29-17-24(3)18-30(20-29)36(45)40(6)25(4)28-15-11-8-12-16-28/h7-18,20,23,25-26,31-33,37,41-42H,19,21-22H2,1-6H3,(H,38,44)(H,39,43)	ZKMCMCMWGYTFGC-UHFFFAOYSA-N	172742	US9096541, 213	Beta-secretase 2		 1.005								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172742&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797803	312696753							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317716	NC1=Nc2ccc(Oc3ccccc3)cc2CN1C(CCC(=O)N(CC1CCC(=O)N1)C1CCCCC1)C1CCCCC1	InChI=1S/C35H47N5O3/c36-35-38-31-18-17-30(43-29-14-8-3-9-15-29)22-26(31)23-40(35)32(25-10-4-1-5-11-25)19-21-34(42)39(28-12-6-2-7-13-28)24-27-16-20-33(41)37-27/h3,8-9,14-15,17-18,22,25,27-28,32H,1-2,4-7,10-13,16,19-21,23-24H2,(H2,36,38)(H,37,41)	MWPFNYBDOHKZHA-UHFFFAOYSA-N	172732	US9096541, 810	Beta-secretase 2		 48								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172732&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797795	312696743							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317717	CC(C)CN1CCNC(C1)C(O)C(Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)NC(C)c1ccccc1)N(C)S(C)(=O)=O	InChI=1S/C35H47N5O5S/c1-24(2)22-40-17-16-36-32(23-40)33(41)31(18-26-12-8-6-9-13-26)38-35(43)29-19-28(20-30(21-29)39(4)46(5,44)45)34(42)37-25(3)27-14-10-7-11-15-27/h6-15,19-21,24-25,31-33,36,41H,16-18,22-23H2,1-5H3,(H,37,42)(H,38,43)	NJFKSQQOYRYGKP-UHFFFAOYSA-N	172733	US9096541, 910	Beta-secretase 2		 6063								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172733&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			77443271	312696744							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317718	CSC[C@H](NC(=O)C1NOC2OCCC12)C(=O)NC(CC(C)C)[C@@H](O)CC(C)C(=O)NC(C(C)C)C(=O)N(C)C	InChI=1S/C27H49N5O7S/c1-14(2)11-18(20(33)12-16(5)23(34)30-21(15(3)4)26(37)32(6)7)28-24(35)19(13-40-8)29-25(36)22-17-9-10-38-27(17)39-31-22/h14-22,27,31,33H,9-13H2,1-8H3,(H,28,35)(H,29,36)(H,30,34)/t16?,17?,18?,19-,20-,21?,22?,27?/m0/s1	WKRLYQINBHBBJC-HVZPKMKHSA-N	172734	US9096541, 1910	Beta-secretase 2		 46								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172734&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797796	312696745					C03800		1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317719	COCC(NC(=O)OCC(C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N)C(=O)N(C)C	InChI=1S/C29H39N5O5/c1-33(2)27(35)25(18-37-3)32-29(36)38-19-26(20-10-6-4-7-11-20)34-17-21-16-23(14-15-24(21)31-28(34)30)39-22-12-8-5-9-13-22/h5,8-9,12-16,20,25-26H,4,6-7,10-11,17-19H2,1-3H3,(H2,30,31)(H,32,36)	DFVGLXQXMNGSMB-UHFFFAOYSA-N	172735	US9096541, 1110	Beta-secretase 2		 350								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172735	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172735&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			78166224	312696746							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317720	CC(C)CC(NC(=O)[C@H](CS(C)(=O)=O)NC(=O)C1NOC2OCCC12)[C@@H](O)CC(C)C(=O)NC(C(C)C)C(=O)N(C)C	InChI=1S/C27H49N5O9S/c1-14(2)11-18(20(33)12-16(5)23(34)30-21(15(3)4)26(37)32(6)7)28-24(35)19(13-42(8,38)39)29-25(36)22-17-9-10-40-27(17)41-31-22/h14-22,27,31,33H,9-13H2,1-8H3,(H,28,35)(H,29,36)(H,30,34)/t16?,17?,18?,19-,20-,21?,22?,27?/m0/s1	UWXPGRHURKVHPR-HVZPKMKHSA-N	172736	US9096541, 2710	Beta-secretase 2		 53								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172736&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797797	312696747							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317721	Cc1ncsc1CN(C1CCCCC1)C(=O)CCC(C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N	InChI=1S/C35H45N5O2S/c1-25-33(43-24-37-25)23-39(28-13-7-3-8-14-28)34(41)20-19-32(26-11-5-2-6-12-26)40-22-27-21-30(17-18-31(27)38-35(40)36)42-29-15-9-4-10-16-29/h4,9-10,15-18,21,24,26,28,32H,2-3,5-8,11-14,19-20,22-23H2,1H3,(H2,36,38)	RWBFFGLASJRBLC-UHFFFAOYSA-N	172737	US9096541, 1549	Beta-secretase 2		 53								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172737&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797798	312696748							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317722	Cc1oncc1CN(C1CCCCC1)C(=O)CCC(C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N	InChI=1S/C35H45N5O3/c1-25-28(22-37-43-25)24-39(29-13-7-3-8-14-29)34(41)20-19-33(26-11-5-2-6-12-26)40-23-27-21-31(17-18-32(27)38-35(40)36)42-30-15-9-4-10-16-30/h4,9-10,15-18,21-22,26,29,33H,2-3,5-8,11-14,19-20,23-24H2,1H3,(H2,36,38)	QCHQOBGIUWWBLB-UHFFFAOYSA-N	172738	US9096541, 1589	Beta-secretase 2		 70								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172738&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797799	312696749							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317723	COc1ccc(cc1)C(C(C)O)C(Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)NC(C)c1ccccc1)N(C)S(C)(=O)=O	InChI=1S/C36H41N3O6S/c1-24(27-14-10-7-11-15-27)37-35(41)29-21-30(23-31(22-29)39(3)46(5,43)44)36(42)38-33(20-26-12-8-6-9-13-26)34(25(2)40)28-16-18-32(45-4)19-17-28/h6-19,21-25,33-34,40H,20H2,1-5H3,(H,37,41)(H,38,42)	HUMBKHWZGADBTM-UHFFFAOYSA-N	172739	US9096541, 111	Beta-secretase 2			 700							US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172739&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797800	312696750							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317724	CC(C)CNC(=O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)NC(C)c1ccccc1)N(C)S(C)(=O)=O)C(C)O	InChI=1S/C36H49N5O7S/c1-23(2)21-38-36(46)33(25(4)42)37-22-32(43)31(17-26-13-9-7-10-14-26)40-35(45)29-18-28(19-30(20-29)41(5)49(6,47)48)34(44)39-24(3)27-15-11-8-12-16-27/h7-16,18-20,23-25,31-33,37,42-43H,17,21-22H2,1-6H3,(H,38,46)(H,39,44)(H,40,45)	ZIEVAMMZKBNDFB-UHFFFAOYSA-N	172741	US9096541, 211	Beta-secretase 2		 37								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172741&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	5E7	5DQC	118797802	312696752							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317725	CC(C)CNC(=O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)NC(C)c1ccc(I)cc1)N(C)S(C)(=O)=O)C(C)O	InChI=1S/C36H48IN5O7S/c1-22(2)20-39-36(47)33(24(4)43)38-21-32(44)31(16-25-10-8-7-9-11-25)41-35(46)28-17-27(18-30(19-28)42(5)50(6,48)49)34(45)40-23(3)26-12-14-29(37)15-13-26/h7-15,17-19,22-24,31-33,38,43-44H,16,20-21H2,1-6H3,(H,39,47)(H,40,45)(H,41,46)	ZJLZPMIAUGHSSO-UHFFFAOYSA-N	172743	US9096541, 711	Beta-secretase 2		 89								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172743	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172743&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797804	312696754							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317726	CC(CN1Cc2cc(Oc3ccccc3)ccc2N=C1N)C(=O)NCCC(C)(C)C	InChI=1S/C24H32N4O2/c1-17(22(29)26-13-12-24(2,3)4)15-28-16-18-14-20(10-11-21(18)27-23(28)25)30-19-8-6-5-7-9-19/h5-11,14,17H,12-13,15-16H2,1-4H3,(H2,25,27)(H,26,29)	VPQNADLZZTVAMP-UHFFFAOYSA-N	172744	US9096541, 2211	Beta-secretase 2			 500							US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172744	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172744&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797805	312696755							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317727	COc1cccc(c1)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)NC(C)c1ccccc1)N(C)S(C)(=O)=O)C(C)O	InChI=1S/C38H46N4O7S/c1-25(28-15-10-7-11-16-28)40-37(45)30-20-31(22-32(21-30)42(3)50(5,47)48)38(46)41-34(19-27-13-8-6-9-14-27)35(44)24-39-36(26(2)43)29-17-12-18-33(23-29)49-4/h6-18,20-23,25-26,34-36,39,43-44H,19,24H2,1-5H3,(H,40,45)(H,41,46)	ZVIRRZKUIQYJIP-UHFFFAOYSA-N	172745	US9096541, 2611	Beta-secretase 2			 350							US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172745&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797806	312696756							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317728	CCCC(O)N(NC[C@H](Cc1ccccc1)NC(=O)c1cc2N(C)S(=O)(=O)C3(CC3)Cn3cc(CC)c(c1)c23)C(=O)NCC(C)C	InChI=1S/C34H48N6O5S/c1-6-11-30(41)40(33(43)35-19-23(3)4)36-20-27(16-24-12-9-8-10-13-24)37-32(42)26-17-28-25(7-2)21-39-22-34(14-15-34)46(44,45)38(5)29(18-26)31(28)39/h8-10,12-13,17-18,21,23,27,30,36,41H,6-7,11,14-16,19-20,22H2,1-5H3,(H,35,43)(H,37,42)/t27-,30?/m0/s1	XOVSNCAGHXXSAO-CEBUJLNPSA-N	172746	US9096541, 3511	Beta-secretase 2		 11								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172746&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797807	312696757							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317729	CCCC(O)N(NC[C@H](Cc1ccccc1)NC(=O)c1cc2N(C)S(=O)(=O)C3(CC3)Cn3cc(CC)c(c1)c23)C(=O)NC(C)C	InChI=1S/C33H46N6O5S/c1-6-11-29(40)39(32(42)35-22(3)4)34-19-26(16-23-12-9-8-10-13-23)36-31(41)25-17-27-24(7-2)20-38-21-33(14-15-33)45(43,44)37(5)28(18-25)30(27)38/h8-10,12-13,17-18,20,22,26,29,34,40H,6-7,11,14-16,19,21H2,1-5H3,(H,35,42)(H,36,41)/t26-,29?/m0/s1	DFJSETUSMWJQBR-QUWDGAPNSA-N	172747	US9096541, 4311	Beta-secretase 2		 30								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172747&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797808	312696758							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317730	CCc1cn2CC3(CC3)S(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)C(O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C34H37F3N4O4S/c1-3-24-20-41-21-33(12-13-33)46(44,45)40(2)29-17-25(16-27(24)31(29)41)32(43)39-28(15-22-8-5-4-6-9-22)30(42)19-38-18-23-10-7-11-26(14-23)34(35,36)37/h4-11,14,16-17,20,28,30,38,42H,3,12-13,15,18-19,21H2,1-2H3,(H,39,43)/t28-,30?/m0/s1	NHYWUCOSILIYIJ-MBCWZBCWSA-N	172748	US9096541, 5211	Beta-secretase 2		 521								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172748&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797809	312696759							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317731	CCc1cn2CC3(CC3)S(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(COC)c1cccc(c1)C(F)(F)F	InChI=1S/C36H41F3N4O5S/c1-4-24-20-43-22-35(13-14-35)49(46,47)42(2)31-18-26(17-28(24)33(31)43)34(45)41-29(15-23-9-6-5-7-10-23)32(44)19-40-30(21-48-3)25-11-8-12-27(16-25)36(37,38)39/h5-12,16-18,20,29-30,32,40,44H,4,13-15,19,21-22H2,1-3H3,(H,41,45)/t29-,30?,32+/m0/s1	NRFXMHZRXOAGNB-LIHWSVDJSA-N	172731	US9096541, 5511	Beta-secretase 2		 199								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89836338	312696742							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317732	CC(C)CNC(=O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cccc(c1)C(=O)N(C)C(C)c1ccccc1)C(C)O	InChI=1S/C35H46N4O5/c1-23(2)21-37-34(43)32(25(4)40)36-22-31(41)30(19-26-13-8-6-9-14-26)38-33(42)28-17-12-18-29(20-28)35(44)39(5)24(3)27-15-10-7-11-16-27/h6-18,20,23-25,30-32,36,40-41H,19,21-22H2,1-5H3,(H,37,43)(H,38,42)	RLSADXVPOTXGOV-UHFFFAOYSA-N	172749	US9096541, 6212	Beta-secretase 2		 63.1								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172749	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172749&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797810	312696760							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317733	CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cccc(c1)C(=O)N(C)C(C)c1ccccc1)C(=O)NCC(C)C	InChI=1S/C37H50N4O5/c1-6-14-32(42)34(36(45)39-23-25(2)3)38-24-33(43)31(21-27-15-9-7-10-16-27)40-35(44)29-19-13-20-30(22-29)37(46)41(5)26(4)28-17-11-8-12-18-28/h7-13,15-20,22,25-26,31-34,38,42-43H,6,14,21,23-24H2,1-5H3,(H,39,45)(H,40,44)	PHXSVGGLTIKXSW-UHFFFAOYSA-N	172750	US9096541, 6412	Beta-secretase 2		 0.02								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172750&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797811	312696761							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317734	CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cccc(c1)C(=O)N1CCCC1OC)C(=O)NCC(C)C	InChI=1S/C33H48N4O6/c1-5-11-27(38)30(32(41)35-20-22(2)3)34-21-28(39)26(18-23-12-7-6-8-13-23)36-31(40)24-14-9-15-25(19-24)33(42)37-17-10-16-29(37)43-4/h6-9,12-15,19,22,26-30,34,38-39H,5,10-11,16-18,20-21H2,1-4H3,(H,35,41)(H,36,40)	JICMITPNTOPAGH-UHFFFAOYSA-N	172751	US9096541, 6512	Beta-secretase 2		 76.6								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172751&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797812	312696762							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
317735	CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C)cc(c1)C(=O)N1CCCC1OC)C(=O)NCC(C)C	InChI=1S/C34H50N4O6/c1-6-11-28(39)31(33(42)36-20-22(2)3)35-21-29(40)27(18-24-12-8-7-9-13-24)37-32(41)25-16-23(4)17-26(19-25)34(43)38-15-10-14-30(38)44-5/h7-9,12-13,16-17,19,22,27-31,35,39-40H,6,10-11,14-15,18,20-21H2,1-5H3,(H,36,42)(H,37,41)	WFZPJFBWUKKUTA-UHFFFAOYSA-N	172752	US9096541, 6612	Beta-secretase 2		 19.7								US Patent		10.7270/Q2TH8KF4		aid1801462	US9096541	Tang, J; Huang, X; Downs, D; Ghosh, AK	Oklahoma Medical Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=172752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=172752&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118797813	312696763							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330392	COc1nc(nc(C)c1F)N1C[C@@H]2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C18H21FN6O3S/c1-11-14(19)15(28-3)22-17(21-11)25-9-13-18(10-25,12-7-5-4-6-8-12)23-16(20)24(2)29(13,26)27/h4-8,13H,9-10H2,1-3H3,(H2,20,23)/t13-,18-/m1/s1	RAJFOQGJKWKNCJ-FZKQIMNGSA-N	182825	US9145426, 1	Beta-secretase 2		 16						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182825	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182825&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71469249	313634348							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330393	COc1nc(nc(C)c1F)N1C[C@@H]2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1ccc(F)cc1	InChI=1S/C18H20F2N6O3S/c1-10-14(20)15(29-3)23-17(22-10)26-8-13-18(9-26,11-4-6-12(19)7-5-11)24-16(21)25(2)30(13,27)28/h4-7,13H,8-9H2,1-3H3,(H2,21,24)/t13-,18-/m1/s1	DHRFNWXFLKOLNR-FZKQIMNGSA-N	182826	US9145426, 2	Beta-secretase 2		 14						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182826	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182826&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467454	313634349							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330394	COc1nc(nc(C)c1F)N1C[C@@H]2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1cc(F)ccc1F	InChI=1S/C18H19F3N6O3S/c1-9-14(21)15(30-3)24-17(23-9)27-7-13-18(8-27,11-6-10(19)4-5-12(11)20)25-16(22)26(2)31(13,28)29/h4-6,13H,7-8H2,1-3H3,(H2,22,25)/t13-,18-/m1/s1	PJENNDSOZAYZKS-FZKQIMNGSA-N	182827	US9145426, 3	Beta-secretase 2		 14						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182827	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182827&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467455	313634350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330395	COc1nc(nc(C)c1F)N1C[C@@H]2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1F	InChI=1S/C18H20F2N6O3S/c1-10-14(20)15(29-3)23-17(22-10)26-8-13-18(9-26,11-6-4-5-7-12(11)19)24-16(21)25(2)30(13,27)28/h4-7,13H,8-9H2,1-3H3,(H2,21,24)/t13-,18-/m1/s1	ROMLSHBTGHTQFO-FZKQIMNGSA-N	182828	US9145426, 4	Beta-secretase 2		 5.4						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182828	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182828&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467456	313634351							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330396	COc1nc(nc(C)c1F)N1C[C@@H]2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1cc(F)c(F)cc1F	InChI=1S/C18H18F4N6O3S/c1-8-14(22)15(31-3)25-17(24-8)28-6-13-18(7-28,26-16(23)27(2)32(13,29)30)9-4-11(20)12(21)5-10(9)19/h4-5,13H,6-7H2,1-3H3,(H2,23,26)/t13-,18-/m1/s1	MBLRMPGNVDAPAO-FZKQIMNGSA-N	182829	US9145426, 5	Beta-secretase 2		 19						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182829	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182829&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89935637	313634352							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330397	COc1nc(nc(C)c1F)N1CC2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1ccc(F)cc1F	InChI=1S/C18H19F3N6O3S/c1-9-14(21)15(30-3)24-17(23-9)27-7-13-18(8-27,11-5-4-10(19)6-12(11)20)25-16(22)26(2)31(13,28)29/h4-6,13H,7-8H2,1-3H3,(H2,22,25)/t13?,18-/m1/s1	XWNJDDMJAWDTOP-PQJIZZRHSA-N	182830	US9145426, 6	Beta-secretase 2		 8.5						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182830	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182830&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89935602	313634353							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330398	COCc1cc(OC)nc(c1)N1CC2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1cc(F)c(F)cc1F	InChI=1S/C20H22F3N5O4S/c1-27-19(24)26-20(12-6-14(22)15(23)7-13(12)21)10-28(8-16(20)33(27,29)30)17-4-11(9-31-2)5-18(25-17)32-3/h4-7,16H,8-10H2,1-3H3,(H2,24,26)/t16?,20-/m1/s1	IPERHZYEDFZZOI-OTOKDRCRSA-N	182831	US9145426, 7	Beta-secretase 2		 3.2						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182831	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182831&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89037076	313634354							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330399	COCc1cc(OC)nc(c1)N1CC2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1F	InChI=1S/C20H24FN5O4S/c1-25-19(22)24-20(14-6-4-5-7-15(14)21)12-26(10-16(20)31(25,27)28)17-8-13(11-29-2)9-18(23-17)30-3/h4-9,16H,10-12H2,1-3H3,(H2,22,24)/t16?,20-/m1/s1	XVLHCJBZYYLELI-OTOKDRCRSA-N	182832	US9145426, 8	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182832	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182832&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			60150638	313634355							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330400	COCc1cc(OC)nc(c1)N1C[C@@H]2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1cc(F)ccc1F	InChI=1S/C20H23F2N5O4S/c1-26-19(23)25-20(14-8-13(21)4-5-15(14)22)11-27(9-16(20)32(26,28)29)17-6-12(10-30-2)7-18(24-17)31-3/h4-8,16H,9-11H2,1-3H3,(H2,23,25)/t16-,20-/m1/s1	XJXSUJBHBZPHLU-OXQOHEQNSA-N	182833	US9145426, 9	Beta-secretase 2		 1.7						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182833	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182833&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89037084	313634356							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330401	COc1nc(nc(C)c1F)N1CC2C(C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C18H21FN6O3S/c1-11-14(19)15(28-3)22-17(21-11)25-9-13-18(10-25,12-7-5-4-6-8-12)23-16(20)24(2)29(13,26)27/h4-8,13H,9-10H2,1-3H3,(H2,20,23)	RAJFOQGJKWKNCJ-UHFFFAOYSA-N	182834	US9145426, 10	Beta-secretase 2		 57						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182834	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182834&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467729	313634357							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330402	CCOCc1cc(OC)nc(c1)N1CC2C(C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C21H27N5O4S/c1-4-30-13-15-10-18(23-19(11-15)29-3)26-12-17-21(14-26,16-8-6-5-7-9-16)24-20(22)25(2)31(17,27)28/h5-11,17H,4,12-14H2,1-3H3,(H2,22,24)	OCCCKEDUBNBLLE-UHFFFAOYSA-N	182835	US9145426, 11	Beta-secretase 2		 6.7						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182835	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182835&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89037087	313634358							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330403	COCc1cc(OC)nc(c1)N1CC2C(C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C20H25N5O4S/c1-24-19(21)23-20(15-7-5-4-6-8-15)13-25(11-16(20)30(24,26)27)17-9-14(12-28-2)10-18(22-17)29-3/h4-10,16H,11-13H2,1-3H3,(H2,21,23)	LELOSQBFNBDVQT-UHFFFAOYSA-N	182836	US9145426, 12	Beta-secretase 2		 6.4						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182836	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182836&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89037092	313634359							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330404	COc1nc(nc(OC)c1F)N1CC2C(C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C18H21FN6O4S/c1-24-16(20)23-18(11-7-5-4-6-8-11)10-25(9-12(18)30(24,26)27)17-21-14(28-2)13(19)15(22-17)29-3/h4-8,12H,9-10H2,1-3H3,(H2,20,23)	XAGYKMOLACATKV-UHFFFAOYSA-N	182837	US9145426, 13	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182837&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467599	313634360							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330405	COc1cccc(n1)N1CC2C(C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C18H21N5O3S/c1-22-17(19)21-18(13-7-4-3-5-8-13)12-23(11-14(18)27(22,24)25)15-9-6-10-16(20-15)26-2/h3-10,14H,11-12H2,1-2H3,(H2,19,21)	ROOHNRUKVDMYSK-UHFFFAOYSA-N	182838	US9145426, 14	Beta-secretase 2		 26						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182838	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182838&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467600	313634361							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330406	CCc1nc(nc(OC)c1F)N1CC2C(C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C19H23FN6O3S/c1-4-13-15(20)16(29-3)23-18(22-13)26-10-14-19(11-26,12-8-6-5-7-9-12)24-17(21)25(2)30(14,27)28/h5-9,14H,4,10-11H2,1-3H3,(H2,21,24)	IDERUORRFCXPDI-UHFFFAOYSA-N	182839	US9145426, 15	Beta-secretase 2		 21						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182839	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182839&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89037072	313634362							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330407	COc1nc(nc(C2CC2)c1F)N1CC2C(C1)(NC(=N)N(C)S2(=O)=O)c1ccccc1	InChI=1S/C20H23FN6O3S/c1-26-18(22)25-20(13-6-4-3-5-7-13)11-27(10-14(20)31(26,28)29)19-23-16(12-8-9-12)15(21)17(24-19)30-2/h3-7,12,14H,8-11H2,1-2H3,(H2,22,25)	HABBKDGVRZWCQT-UHFFFAOYSA-N	182840	US9145426, 16	Beta-secretase 2		 5.7						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182840	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182840&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89037278	313634363							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330408	CN1C(=N)NC2(CN(CC2S1(=O)=O)c1cccc(C)c1)c1ccccc1	InChI=1S/C19H22N4O2S/c1-14-7-6-10-16(11-14)23-12-17-19(13-23,15-8-4-3-5-9-15)21-18(20)22(2)26(17,24)25/h3-11,17H,12-13H2,1-2H3,(H2,20,21)	VRUMKLDKWLDFBY-UHFFFAOYSA-N	182841	US9145426, 17	Beta-secretase 2		 890						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182841	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182841&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467727	313634364							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330409	CN1C(=N)N[C@]2(CN(CC2S1(=O)=O)C(C)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N6O4S/c1-11(29)28-9-17-20(10-28,26-19(23)27(2)33(17,31)32)14-7-13(4-5-15(14)22)25-18(30)16-6-3-12(21)8-24-16/h3-8,17H,9-10H2,1-2H3,(H2,23,26)(H,25,30)/t17?,20-/m1/s1	JDCNHYZNJNRUDX-UUSAFJCLSA-N	182842	US9145426, 18	Beta-secretase 2		 3.2						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182842	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182842&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467726	313634365							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
330410	COc1nc(nc(C)c1F)N1CC2[C@](C1)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H23F3N8O4S/c1-12-19(27)21(39-3)32-23(30-12)35-10-18-24(11-35,33-22(28)34(2)40(18,37)38)15-8-14(5-6-16(15)26)31-20(36)17-7-4-13(25)9-29-17/h4-9,18H,10-11H2,1-3H3,(H2,28,33)(H,31,36)/t18?,24-/m1/s1	HLUAIMQRMMIEHR-VCUSLETLSA-N	182843	US9145426, 19	Beta-secretase 2		 1.6						5	30.00 C	US Patent		10.7270/Q2WH2NSS		aid1801690	US9145426	Stamford, AW; Gilbert, EJ; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182843	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182843&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467728	313634366							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336766	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(C)C)C(=N)N1	InChI=1S/C22H27FN4O4S/c1-13(2)22(4)20(24)27-21(3,12-32(22,29)30)16-10-14(6-8-17(16)23)26-19(28)18-9-7-15(31-5)11-25-18/h6-11,13H,12H2,1-5H3,(H2,24,27)(H,26,28)/t21-,22+/m0/s1	PCPHTKPBCAFRPB-FCHUYYIVSA-N	259061	US9499502, 9eb-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259061&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095073	350083763							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336767	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(C)C)C(=N)N1	InChI=1S/C21H26FN5O4S/c1-12(2)21(4)19(23)27-20(3,11-32(21,29)30)14-8-13(6-7-15(14)22)26-18(28)16-9-25-17(31-5)10-24-16/h6-10,12H,11H2,1-5H3,(H2,23,27)(H,26,28)/t20-,21+/m0/s1	LXQOIJMPBHGPMD-LEWJYISDSA-N	259063	US9499502, 9ec-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259063	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259063&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095081	350083765							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336768	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C2CCOCC2)C(=N)N1	InChI=1S/C24H29FN4O5S/c1-23(14-35(31,32)24(2,22(26)29-23)15-8-10-34-11-9-15)18-12-16(4-6-19(18)25)28-21(30)20-7-5-17(33-3)13-27-20/h4-7,12-13,15H,8-11,14H2,1-3H3,(H2,26,29)(H,28,30)/t23-,24-/m0/s1	HYVHUXJHJXIWRQ-ZEQRLZLVSA-N	259046	US9499502, 9dt-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259046&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095061	350083748							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336769	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1ccc(F)cc1	InChI=1S/C24H23F2N5O4S/c1-23(13-36(33,34)24(2,22(27)31-23)14-4-6-15(25)7-5-14)17-10-16(8-9-18(17)26)30-21(32)19-11-29-20(35-3)12-28-19/h4-12H,13H2,1-3H3,(H2,27,31)(H,30,32)/t23-,24-/m0/s1	QJTNVDROEBMADB-ZEQRLZLVSA-N	259022	US9499502, 9dg-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259022&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562467	350083724							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336770	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H24F2N4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)10-13-3-4-13)16-9-15(6-7-17(16)24)27-19(29)18-8-5-14(23)11-26-18/h5-9,11,13H,3-4,10,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22-/m0/s1	XWMCZTBOAXIOBT-VXKWHMMOSA-N	259024	US9499502, 9dh-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259024&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095311	350083726							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336771	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C2CC2)C(=N)N1	InChI=1S/C21H24FN5O4S/c1-20(11-32(29,30)21(2,12-4-5-12)19(23)27-20)14-8-13(6-7-15(14)22)26-18(28)16-9-25-17(31-3)10-24-16/h6-10,12H,4-5,11H2,1-3H3,(H2,23,27)(H,26,28)/t20-,21-/m0/s1	YJOQTCQWWUCODO-SFTDATJTSA-N	258994	US9499502, 9cq-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258994&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562466	350083696							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336772	CC(C)[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H24F2N4O3S/c1-12(2)21(4)19(24)27-20(3,11-31(21,29)30)15-9-14(6-7-16(15)23)26-18(28)17-8-5-13(22)10-25-17/h5-10,12H,11H2,1-4H3,(H2,24,27)(H,26,28)/t20-,21-/m0/s1	KIIPFTKRIFPZBX-SFTDATJTSA-N	259058	US9499502, 9ea-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259058&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095085	350083760							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336773	C[C@]1(CS(=O)(=O)[C@](C)(CC2CC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H24ClFN4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)10-13-3-4-13)16-9-15(6-7-17(16)24)27-19(29)18-8-5-14(23)11-26-18/h5-9,11,13H,3-4,10,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22+/m0/s1	JJJXCCVDKHDQSS-FCHUYYIVSA-N	259027	US9499502, 9di-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259027&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138917	350083729							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336774	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC2CC2)C(=N)N1	InChI=1S/C22H26FN5O4S/c1-21(12-33(30,31)22(2,20(24)28-21)9-13-4-5-13)15-8-14(6-7-16(15)23)27-19(29)17-10-26-18(32-3)11-25-17/h6-8,10-11,13H,4-5,9,12H2,1-3H3,(H2,24,28)(H,27,29)/t21-,22-/m0/s1	JLERBPKGLVBCHL-VXKWHMMOSA-N	259030	US9499502, 9dk-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259030&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095321	350083732							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336775	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CCOCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H28F2N4O4S/c1-23(14-35(32,33)24(2,22(27)30-23)12-15-7-9-34-10-8-15)18-11-17(4-5-19(18)26)29-21(31)20-6-3-16(25)13-28-20/h3-6,11,13,15H,7-10,12,14H2,1-2H3,(H2,27,30)(H,29,31)/t23-,24-/m0/s1	PYKXQYRULDMMMH-ZEQRLZLVSA-N	258996	US9499502, 9cr-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258996&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094899	350083698							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336776	C[C@]1(CS(=O)(=O)[C@](C)(CC2CC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H24F2N4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)10-13-3-4-13)16-9-15(6-7-17(16)24)27-19(29)18-8-5-14(23)11-26-18/h5-9,11,13H,3-4,10,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22+/m0/s1	XWMCZTBOAXIOBT-FCHUYYIVSA-N	259025	US9499502, 9dh-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259025&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138888	350083727							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336777	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1	InChI=1S/C20H21F4N5O4S/c1-18(10-34(31,32)19(2,17(25)29-18)9-20(22,23)24)12-6-11(4-5-13(12)21)28-16(30)14-7-27-15(33-3)8-26-14/h4-8H,9-10H2,1-3H3,(H2,25,29)(H,28,30)/t18-,19-/m0/s1	AAWWARFYZYVELF-OALUTQOASA-N	259043	US9499502, 9dr-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259043&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095048	350083745							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336778	CC[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2cnc(OC)cn2)ccc1F	InChI=1S/C20H24FN5O4S/c1-5-20(3)18(22)26-19(2,11-31(20,28)29)13-8-12(6-7-14(13)21)25-17(27)15-9-24-16(30-4)10-23-15/h6-10H,5,11H2,1-4H3,(H2,22,26)(H,25,27)/t19-,20-/m0/s1	LKFHXZDIEUQXTP-PMACEKPBSA-N	258990	US9499502, 9cn-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258990&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095277	350083692							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336779	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1	InChI=1S/C24H24FN5O4S/c1-23(14-35(32,33)24(2,22(26)30-23)20-6-4-5-11-27-20)17-12-15(7-9-18(17)25)29-21(31)19-10-8-16(34-3)13-28-19/h4-13H,14H2,1-3H3,(H2,26,30)(H,29,31)/t23-,24-/m0/s1	YIRVRVGMVDIEGI-ZEQRLZLVSA-N	259004	US9499502, 9cx-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259004&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094930	350083706							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336780	CC[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(OC)cn2)ccc1F	InChI=1S/C21H25FN4O4S/c1-5-21(3)19(23)26-20(2,12-31(21,28)29)15-10-13(6-8-16(15)22)25-18(27)17-9-7-14(30-4)11-24-17/h6-11H,5,12H2,1-4H3,(H2,23,26)(H,25,27)/t20-,21-/m0/s1	VLFYEOKWTIJOJW-SFTDATJTSA-N	258988	US9499502, 9cm-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258988&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095276	350083690							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336781	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C2CCC2)C(=N)N1	InChI=1S/C23H27FN4O4S/c1-22(13-33(30,31)23(2,21(25)28-22)14-5-4-6-14)17-11-15(7-9-18(17)24)27-20(29)19-10-8-16(32-3)12-26-19/h7-12,14H,4-6,13H2,1-3H3,(H2,25,28)(H,27,29)/t22-,23-/m0/s1	BXZFFECLBOOHGF-GOTSBHOMSA-N	259052	US9499502, 9dx-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259052&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095063	350083754							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336782	C[C@]1(CS(=O)(=O)[C@@](C)(C2CCOCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C23H26F2N4O4S/c1-22(13-34(31,32)23(2,21(26)29-22)14-7-9-33-10-8-14)17-11-16(4-5-18(17)25)28-20(30)19-6-3-15(24)12-27-19/h3-6,11-12,14H,7-10,13H2,1-2H3,(H2,26,29)(H,28,30)/t22-,23-/m0/s1	GTUNULWCWIOILM-GOTSBHOMSA-N	259045	US9499502, 9ds-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259045&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095052	350083747							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336783	C[C@]1(CS(=O)(=O)[C@@](C)(C2CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C23H24F4N4O3S/c1-21(12-35(33,34)22(2,20(28)31-21)13-4-3-5-13)16-10-15(7-8-17(16)24)30-19(32)18-9-6-14(11-29-18)23(25,26)27/h6-11,13H,3-5,12H2,1-2H3,(H2,28,31)(H,30,32)/t21-,22-/m0/s1	XLKKPKIXUHYZCJ-VXKWHMMOSA-N	259056	US9499502, 9dz-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259056&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095077	350083758							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336784	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C23H24F4N4O3S/c1-21(12-35(33,34)22(2,20(28)31-21)10-13-3-4-13)16-9-15(6-7-17(16)24)30-19(32)18-8-5-14(11-29-18)23(25,26)27/h5-9,11,13H,3-4,10,12H2,1-2H3,(H2,28,31)(H,30,32)/t21-,22-/m0/s1	YOULZVFEEDUUAK-VXKWHMMOSA-N	259032	US9499502, 9dl-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259032&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095324	350083734							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336785	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC2CCOCC2)C(=N)N1	InChI=1S/C24H30FN5O5S/c1-23(14-36(32,33)24(2,22(26)30-23)11-15-6-8-35-9-7-15)17-10-16(4-5-18(17)25)29-21(31)19-12-28-20(34-3)13-27-19/h4-5,10,12-13,15H,6-9,11,14H2,1-3H3,(H2,26,30)(H,29,31)/t23-,24-/m0/s1	XSWUKTIPUCIOSI-ZEQRLZLVSA-N	258998	US9499502, 9ct-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258998&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094895	350083700							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336786	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H21ClF2N4O3S/c1-23(13-35(33,34)24(2,22(28)31-23)14-4-3-5-16(26)10-14)18-11-17(7-8-19(18)27)30-21(32)20-9-6-15(25)12-29-20/h3-12H,13H2,1-2H3,(H2,28,31)(H,30,32)/t23-,24-/m0/s1	KEQJGRSKJJVNOG-ZEQRLZLVSA-N	259012	US9499502, 9db-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259012&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094918	350083714							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336787	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(c1)C(F)(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C25H21F5N4O3S/c1-23(18-11-17(7-8-19(18)27)33-21(35)20-9-6-16(26)12-32-20)13-38(36,37)24(2,22(31)34-23)14-4-3-5-15(10-14)25(28,29)30/h3-12H,13H2,1-2H3,(H2,31,34)(H,33,35)/t23-,24-/m0/s1	UXGVJSLILMOHEE-ZEQRLZLVSA-N	258992	US9499502, 9co-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258992&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094892	350083694							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336788	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccc(F)cc1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H21F3N4O3S/c1-23(13-35(33,34)24(2,22(28)31-23)14-3-5-15(25)6-4-14)18-11-17(8-9-19(18)27)30-21(32)20-10-7-16(26)12-29-20/h3-12H,13H2,1-2H3,(H2,28,31)(H,30,32)/t23-,24-/m0/s1	VVJCOAYBPYZDAC-ZEQRLZLVSA-N	259020	US9499502, 9df-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259020&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094941	350083722							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336789	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1	InChI=1S/C24H23F2N5O4S/c1-23(13-36(33,34)24(2,22(27)31-23)14-5-4-6-15(25)9-14)17-10-16(7-8-18(17)26)30-21(32)19-11-29-20(35-3)12-28-19/h4-12H,13H2,1-3H3,(H2,27,31)(H,30,32)/t23-,24-/m0/s1	TWYSRUPDRPYBJC-ZEQRLZLVSA-N	259016	US9499502, 9dd-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259016&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094943	350083718							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336790	CC[C@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H22F2N4O3S/c1-4-20(3)18(23)26-19(2,11-30(20,28)29)14-9-13(6-7-15(14)22)25-17(27)16-8-5-12(21)10-24-16/h5-10H,4,11H2,1-3H3,(H2,23,26)(H,25,27)/t19-,20+/m0/s1	HHLLIOKPEHPPFR-VQTJNVASSA-N	258987	US9499502, 9cl-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258987&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095038	350083689							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336791	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccc1F	InChI=1S/C25H24F2N4O4S/c1-24(14-36(33,34)25(2,23(28)31-24)17-6-4-5-7-19(17)26)18-12-15(8-10-20(18)27)30-22(32)21-11-9-16(35-3)13-29-21/h4-13H,14H2,1-3H3,(H2,28,31)(H,30,32)/t24-,25+/m0/s1	DBRZLTWINADIHS-LOSJGSFVSA-N	259038	US9499502, 9do-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259038&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953974	350083740							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336792	CC[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H22F2N4O3S/c1-4-20(3)18(23)26-19(2,11-30(20,28)29)14-9-13(6-7-15(14)22)25-17(27)16-8-5-12(21)10-24-16/h5-10H,4,11H2,1-3H3,(H2,23,26)(H,25,27)/t19-,20-/m0/s1	HHLLIOKPEHPPFR-PMACEKPBSA-N	258986	US9499502, 9cl-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258986&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095040	350083688							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336793	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(=N)N1)c1cc(ccn1)C(F)(F)F	InChI=1S/C24H22F4N6O4S/c1-22(15-9-14(4-5-16(15)25)33-20(35)17-10-32-19(38-3)11-31-17)12-39(36,37)23(2,21(29)34-22)18-8-13(6-7-30-18)24(26,27)28/h4-11H,12H2,1-3H3,(H2,29,34)(H,33,35)/t22-,23+/m0/s1	HSZFAIAMGODYEK-XZOQPEGZSA-N	259066	US9499502, 9ee-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259066&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095082	350083767							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336794	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cc(ccn1)C(F)(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H20F5N5O3S/c1-22(16-10-15(4-5-17(16)26)33-20(35)18-6-3-14(25)11-32-18)12-38(36,37)23(2,21(30)34-22)19-9-13(7-8-31-19)24(27,28)29/h3-11H,12H2,1-2H3,(H2,30,34)(H,33,35)/t22-,23-/m0/s1	PLCDXUBBYUCKTP-GOTSBHOMSA-N	259064	US9499502, 9ed-a::US9499502, 9ed-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259064	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259064&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094944	350083766							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336795	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(C)C)C(=N)N1	InChI=1S/C22H27FN4O4S/c1-13(2)22(4)20(24)27-21(3,12-32(22,29)30)16-10-14(6-8-17(16)23)26-19(28)18-9-7-15(31-5)11-25-18/h6-11,13H,12H2,1-5H3,(H2,24,27)(H,26,28)/t21-,22-/m0/s1	PCPHTKPBCAFRPB-VXKWHMMOSA-N	259060	US9499502, 9eb-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259060&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095071	350083762							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336796	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cc(ccn1)C(F)(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H20F5N5O3S/c1-22(16-10-15(4-5-17(16)26)33-20(35)18-6-3-14(25)11-32-18)12-38(36,37)23(2,21(30)34-22)19-9-13(7-8-31-19)24(27,28)29/h3-11H,12H2,1-2H3,(H2,30,34)(H,33,35)/t22-,23-/m0/s1	PLCDXUBBYUCKTP-GOTSBHOMSA-N	259064	US9499502, 9ed-a::US9499502, 9ed-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259064	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259064&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094944	350083766							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336797	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC2CC2)C(=N)N1	InChI=1S/C23H27FN4O4S/c1-22(13-33(30,31)23(2,21(25)28-22)11-14-4-5-14)17-10-15(6-8-18(17)24)27-20(29)19-9-7-16(32-3)12-26-19/h6-10,12,14H,4-5,11,13H2,1-3H3,(H2,25,28)(H,27,29)/t22-,23-/m0/s1	VQKHUABFISOOBU-GOTSBHOMSA-N	259028	US9499502, 9dj-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259028&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095313	350083730							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336798	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C2CCOCC2)C(=N)N1	InChI=1S/C23H28FN5O5S/c1-22(13-35(31,32)23(2,21(25)29-22)14-6-8-34-9-7-14)16-10-15(4-5-17(16)24)28-20(30)18-11-27-19(33-3)12-26-18/h4-5,10-12,14H,6-9,13H2,1-3H3,(H2,25,29)(H,28,30)/t22-,23-/m0/s1	JYEJLFRHSIRTMY-GOTSBHOMSA-N	259047	US9499502, 9du-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259047&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095055	350083749							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336799	C[C@]1(CS(=O)(=O)[C@@](C)(C2CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H24ClFN4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)13-4-3-5-13)16-10-15(7-8-17(16)24)27-19(29)18-9-6-14(23)11-26-18/h6-11,13H,3-5,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22-/m0/s1	VMLHVAKZZJPKPK-VXKWHMMOSA-N	259050	US9499502, 9dw-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259050&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095058	350083752							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336800	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC=C)C(=N)N1	InChI=1S/C21H24FN5O4S/c1-5-8-21(3)19(23)27-20(2,12-32(21,29)30)14-9-13(6-7-15(14)22)26-18(28)16-10-25-17(31-4)11-24-16/h5-7,9-11H,1,8,12H2,2-4H3,(H2,23,27)(H,26,28)/t20-,21-/m0/s1	ZUJKHLJVNCJGJC-SFTDATJTSA-N	259034	US9499502, 9dm-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259034&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095042	350083736							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336801	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(F)c1	InChI=1S/C25H24F2N4O4S/c1-24(14-36(33,34)25(2,23(28)31-24)15-5-4-6-16(26)11-15)19-12-17(7-9-20(19)27)30-22(32)21-10-8-18(35-3)13-29-21/h4-13H,14H2,1-3H3,(H2,28,31)(H,30,32)/t24-,25+/m0/s1	LQELPBBEOLZTLK-LOSJGSFVSA-N	259015	US9499502, 9dc-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259015&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094961	350083717							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336802	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H21F3N4O3S/c1-23(13-35(33,34)24(2,22(28)31-23)14-4-3-5-15(25)10-14)18-11-17(7-8-19(18)27)30-21(32)20-9-6-16(26)12-29-20/h3-12H,13H2,1-2H3,(H2,28,31)(H,30,32)/t23-,24-/m0/s1	PRMNIEKLGGVFHS-ZEQRLZLVSA-N	259010	US9499502, 9da-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259010&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094913	350083712							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336803	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccc1F	InChI=1S/C25H24F2N4O4S/c1-24(14-36(33,34)25(2,23(28)31-24)17-6-4-5-7-19(17)26)18-12-15(8-10-20(18)27)30-22(32)21-11-9-16(35-3)13-29-21/h4-13H,14H2,1-3H3,(H2,28,31)(H,30,32)/t24-,25-/m0/s1	DBRZLTWINADIHS-DQEYMECFSA-N	259037	US9499502, 9do-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259037&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095050	350083739							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336804	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C2CCC2)C(=N)N1	InChI=1S/C22H26FN5O4S/c1-21(12-33(30,31)22(2,20(24)28-21)13-5-4-6-13)15-9-14(7-8-16(15)23)27-19(29)17-10-26-18(32-3)11-25-17/h7-11,13H,4-6,12H2,1-3H3,(H2,24,28)(H,27,29)/t21-,22-/m0/s1	YZOGZKNAXGTHLN-VXKWHMMOSA-N	259054	US9499502, 9dy-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259054&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095060	350083756							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336805	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C23H21ClFN5O3S/c1-22(13-34(32,33)23(2,21(26)30-22)19-5-3-4-10-27-19)16-11-15(7-8-17(16)25)29-20(31)18-9-6-14(24)12-28-18/h3-12H,13H2,1-2H3,(H2,26,30)(H,29,31)/t22-,23-/m0/s1	SSWZFIYACUIXCL-GOTSBHOMSA-N	259002	US9499502, 9cw-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259002&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094906	350083704							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336806	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1	InChI=1S/C21H22F4N4O4S/c1-19(11-34(31,32)20(2,18(26)29-19)10-21(23,24)25)14-8-12(4-6-15(14)22)28-17(30)16-7-5-13(33-3)9-27-16/h4-9H,10-11H2,1-3H3,(H2,26,29)(H,28,30)/t19-,20-/m0/s1	STIIUEJIVDAURY-PMACEKPBSA-N	259041	US9499502, 9dq-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259041	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259041&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095049	350083743							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336807	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccc1F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H21F3N4O3S/c1-23(13-35(33,34)24(2,22(28)31-23)16-5-3-4-6-18(16)26)17-11-15(8-9-19(17)27)30-21(32)20-10-7-14(25)12-29-20/h3-12H,13H2,1-2H3,(H2,28,31)(H,30,32)/t23-,24-/m0/s1	LAGKJKVPNPKJGZ-ZEQRLZLVSA-N	259036	US9499502, 9dn-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259036&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095043	350083738							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336808	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C23H21F2N5O3S/c1-22(13-34(32,33)23(2,21(26)30-22)19-5-3-4-10-27-19)16-11-15(7-8-17(16)25)29-20(31)18-9-6-14(24)12-28-18/h3-12H,13H2,1-2H3,(H2,26,30)(H,29,31)/t22-,23-/m0/s1	NJTYDCSGUKEPCM-GOTSBHOMSA-N	259000	US9499502, 9cv-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259000&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094898	350083702							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336809	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C25H21F5N4O3S/c1-23(13-38(36,37)24(2,22(31)34-23)14-4-3-5-16(26)10-14)18-11-17(7-8-19(18)27)33-21(35)20-9-6-15(12-32-20)25(28,29)30/h3-12H,13H2,1-2H3,(H2,31,34)(H,33,35)/t23-,24-/m0/s1	TUMLJMNTYBWVIP-ZEQRLZLVSA-N	259018	US9499502, 9de-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259018	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259018&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094967	350083720							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336810	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(CC2CC2)C(=N)N1	InChI=1S/C23H27FN4O4S/c1-22(13-33(30,31)23(2,21(25)28-22)11-14-4-5-14)17-10-15(6-8-18(17)24)27-20(29)19-9-7-16(32-3)12-26-19/h6-10,12,14H,4-5,11,13H2,1-3H3,(H2,25,28)(H,27,29)/t22-,23+/m0/s1	VQKHUABFISOOBU-XZOQPEGZSA-N	259029	US9499502, 9dj-b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259029&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138887	350083731							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336811	C[C@]1(CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H19F5N4O3S/c1-18(10-33(31,32)19(2,17(26)29-18)9-20(23,24)25)13-7-12(4-5-14(13)22)28-16(30)15-6-3-11(21)8-27-15/h3-8H,9-10H2,1-2H3,(H2,26,29)(H,28,30)/t18-,19-/m0/s1	MYEBJZKTHZULPN-OALUTQOASA-N	259039	US9499502, 9dp-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259039&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095047	350083741							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336812	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H24ClFN4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)10-13-3-4-13)16-9-15(6-7-17(16)24)27-19(29)18-8-5-14(23)11-26-18/h5-9,11,13H,3-4,10,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22-/m0/s1	JJJXCCVDKHDQSS-VXKWHMMOSA-N	259026	US9499502, 9di-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259026&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095315	350083728							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336813	C[C@]1(CS(=O)(=O)[C@@](C)(C2CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H24F2N4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)13-4-3-5-13)16-10-15(7-8-17(16)24)27-19(29)18-9-6-14(23)11-26-18/h6-11,13H,3-5,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22-/m0/s1	UOWARJUDEUSHQR-VXKWHMMOSA-N	259048	US9499502, 9dv-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259048&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095062	350083750							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336814	COCC(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(c1)C(F)(F)F	InChI=1S/C22H23F4N3O4S/c1-20(16-10-15(7-8-17(16)23)28-18(30)11-33-3)12-34(31,32)21(2,19(27)29-20)13-5-4-6-14(9-13)22(24,25)26/h4-10H,11-12H2,1-3H3,(H2,27,29)(H,28,30)/t20-,21-/m0/s1	OLKBIPXUFNAFTP-SFTDATJTSA-N	258993	US9499502, 9cp-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258993&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094890	350083695							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336815	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CCOCC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H28ClFN4O4S/c1-23(14-35(32,33)24(2,22(27)30-23)12-15-7-9-34-10-8-15)18-11-17(4-5-19(18)26)29-21(31)20-6-3-16(25)13-28-20/h3-6,11,13,15H,7-10,12,14H2,1-2H3,(H2,27,30)(H,29,31)/t23-,24-/m0/s1	HYZLKSOUFSGYSX-ZEQRLZLVSA-N	258997	US9499502, 9cs-a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258997&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094896	350083699							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336816	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1nc(ccc1F)-c1cccc(c1)C#N	InChI=1S/C19H19FN4O2S/c1-18(2)17(22)24-19(3,11-27(18,25)26)16-14(20)7-8-15(23-16)13-6-4-5-12(9-13)10-21/h4-9H,11H2,1-3H3,(H2,22,24)/t19-/m0/s1	PWZMGNHIQDPVPR-IBGZPJMESA-N	259072	US9499502, 16b	Beta-secretase 2		 4500						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259072	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259072&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095371	350083773							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336817	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc(ccc1F)-c1ccc(s1)C#N	InChI=1S/C17H17FN4O2S2/c1-16(2)15(20)22-17(3,9-26(16,23)24)14-11(18)5-6-12(21-14)13-7-4-10(8-19)25-13/h4-7H,9H2,1-3H3,(H2,20,22)/t17-/m0/s1	ACESVTTZYFFOEX-KRWDZBQOSA-N	259073	US9499502, 16c	Beta-secretase 2		 4500						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259073&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563593	350083774							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336818	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)Nc1cccc(n1)C(F)(F)F	InChI=1S/C18H18ClF3N4O3S2/c1-16(2)15(23)26-17(3,8-31(16,28)29)13-9(19)7-10(30-13)14(27)25-12-6-4-5-11(24-12)18(20,21)22/h4-7H,8H2,1-3H3,(H2,23,26)(H,24,25,27)/t17-/m0/s1	WQCJARJMGDTQLH-KRWDZBQOSA-N	259078	US9499502, 22	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259078&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563597	350083779							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336819	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)Nc1cccc(F)n1	InChI=1S/C17H18ClFN4O3S2/c1-16(2)15(20)23-17(3,8-28(16,25)26)13-9(18)7-10(27-13)14(24)22-12-6-4-5-11(19)21-12/h4-7H,8H2,1-3H3,(H2,20,23)(H,21,22,24)/t17-/m0/s1	OIWOEZTZAQBFIX-KRWDZBQOSA-N	259077	US9499502, 21	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259077	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259077&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095417	350083778							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336820	COc1cccc(NC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)n1	InChI=1S/C18H21ClN4O4S2/c1-17(2)16(20)23-18(3,9-29(17,25)26)14-10(19)8-11(28-14)15(24)22-12-6-5-7-13(21-12)27-4/h5-8H,9H2,1-4H3,(H2,20,23)(H,21,22,24)/t18-/m0/s1	GRTKPGBKWHBEMJ-SFHVURJKSA-N	259074	US9499502, 18	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259074&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563595	350083775							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336821	CCc1cccc(NC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)n1	InChI=1S/C19H23ClN4O3S2/c1-5-11-7-6-8-14(22-11)23-16(25)13-9-12(20)15(28-13)19(4)10-29(26,27)18(2,3)17(21)24-19/h6-9H,5,10H2,1-4H3,(H2,21,24)(H,22,23,25)/t19-/m0/s1	JOHRAMDBTOOHOP-IBGZPJMESA-N	259075	US9499502, 19	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259075&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095415	350083776							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336822	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccc(cn1)C(F)(F)F	InChI=1S/C19H20ClF3N4O3S2/c1-17(2)16(24)27-18(3,9-32(17,29)30)14-12(20)6-13(31-14)15(28)26-8-11-5-4-10(7-25-11)19(21,22)23/h4-7H,8-9H2,1-3H3,(H2,24,27)(H,26,28)/t18-/m0/s1	DMVZVMCIEFGBAL-SFHVURJKSA-N	259094	US9499502, 22p	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259094&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095373	350083795							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336823	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ncccn1	InChI=1S/C17H20ClN5O3S2/c1-16(2)15(19)23-17(3,9-28(16,25)26)13-10(18)7-11(27-13)14(24)22-8-12-20-5-4-6-21-12/h4-7H,8-9H2,1-3H3,(H2,19,23)(H,22,24)/t17-/m0/s1	PNQPYNBEEGBKET-KRWDZBQOSA-N	259080	US9499502, 22b	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259080	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259080&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563598	350083781							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336824	Cc1cccc(CNC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)n1	InChI=1S/C19H23ClN4O3S2/c1-11-6-5-7-12(23-11)9-22-16(25)14-8-13(20)15(28-14)19(4)10-29(26,27)18(2,3)17(21)24-19/h5-8H,9-10H2,1-4H3,(H2,21,24)(H,22,25)/t19-/m0/s1	QXHVUTQJFFJIIT-IBGZPJMESA-N	259081	US9499502, 22c	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259081	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259081&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094927	350083782							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336825	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCC1CCC1	InChI=1S/C17H24ClN3O3S2/c1-16(2)15(19)21-17(3,9-26(16,23)24)13-11(18)7-12(25-13)14(22)20-8-10-5-4-6-10/h7,10H,4-6,8-9H2,1-3H3,(H2,19,21)(H,20,22)/t17-/m0/s1	PKUUIADSODNCBR-KRWDZBQOSA-N	259092	US9499502, 22n	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259092&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095305	350083793							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336826	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccc(Cl)cc1	InChI=1S/C19H21Cl2N3O3S2/c1-18(2)17(22)24-19(3,10-29(18,26)27)15-13(21)8-14(28-15)16(25)23-9-11-4-6-12(20)7-5-11/h4-8H,9-10H2,1-3H3,(H2,22,24)(H,23,25)/t19-/m0/s1	PFPJMLWNOHRMJC-IBGZPJMESA-N	259089	US9499502, 22k	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259089&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095318	350083790							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336827	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1cnoc1	InChI=1S/C16H19ClN4O4S2/c1-15(2)14(18)21-16(3,8-27(15,23)24)12-10(17)4-11(26-12)13(22)19-5-9-6-20-25-7-9/h4,6-7H,5,8H2,1-3H3,(H2,18,21)(H,19,22)/t16-/m0/s1	SXRUVICBJGGINR-INIZCTEOSA-N	259095	US9499502, 22q	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259095&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137865	350083796							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336828	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1cnsn1	InChI=1S/C15H18ClN5O3S3/c1-14(2)13(17)20-15(3,7-27(14,23)24)11-9(16)4-10(25-11)12(22)18-5-8-6-19-26-21-8/h4,6H,5,7H2,1-3H3,(H2,17,20)(H,18,22)/t15-/m0/s1	ZTIDQCSNFADZCS-HNNXBMFYSA-N	259096	US9499502, 22r	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259096&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095372	350083797							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336829	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccc2cnccc2c1	InChI=1S/C22H23ClN4O3S2/c1-21(2)20(24)27-22(3,12-32(21,29)30)18-16(23)9-17(31-18)19(28)26-10-13-4-5-15-11-25-7-6-14(15)8-13/h4-9,11H,10,12H2,1-3H3,(H2,24,27)(H,26,28)/t22-/m0/s1	MJEZAOBXCMNILG-QFIPXVFZSA-N	259082	US9499502, 22d	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259082	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259082&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562040	350083783							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336830	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccc(F)cc1	InChI=1S/C19H21ClFN3O3S2/c1-18(2)17(22)24-19(3,10-29(18,26)27)15-13(20)8-14(28-15)16(25)23-9-11-4-6-12(21)7-5-11/h4-8H,9-10H2,1-3H3,(H2,22,24)(H,23,25)/t19-/m0/s1	IAGRVZWLBGRJNT-IBGZPJMESA-N	259088	US9499502, 22j	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259088&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094903	350083789							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336831	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ncc(F)cc1Cl	InChI=1S/C18H19Cl2FN4O3S2/c1-17(2)16(22)25-18(3,8-30(17,27)28)14-11(20)5-13(29-14)15(26)24-7-12-10(19)4-9(21)6-23-12/h4-6H,7-8H2,1-3H3,(H2,22,25)(H,24,26)/t18-/m0/s1	SGPNFMXERJQHIN-SFHVURJKSA-N	259093	US9499502, 22o	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259093&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095319	350083794							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336832	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1cccc(Cl)c1	InChI=1S/C19H21Cl2N3O3S2/c1-18(2)17(22)24-19(3,10-29(18,26)27)15-13(21)8-14(28-15)16(25)23-9-11-5-4-6-12(20)7-11/h4-8H,9-10H2,1-3H3,(H2,22,24)(H,23,25)/t19-/m0/s1	CNMDTYPTQOQLEC-IBGZPJMESA-N	259090	US9499502, 22l	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259090&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095322	350083791							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336833	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ncccc1Cl	InChI=1S/C18H20Cl2N4O3S2/c1-17(2)16(21)24-18(3,9-29(17,26)27)14-11(20)7-13(28-14)15(25)23-8-12-10(19)5-4-6-22-12/h4-7H,8-9H2,1-3H3,(H2,21,24)(H,23,25)/t18-/m0/s1	GABOPLSRGWDCAD-SFHVURJKSA-N	259079	US9499502, 22a	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259079&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094905	350083780							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336834	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccncn1	InChI=1S/C17H20ClN5O3S2/c1-16(2)15(19)23-17(3,8-28(16,25)26)13-11(18)6-12(27-13)14(24)21-7-10-4-5-20-9-22-10/h4-6,9H,7-8H2,1-3H3,(H2,19,23)(H,21,24)/t17-/m0/s1	VALDWZJEAQMPKO-KRWDZBQOSA-N	259098	US9499502, 22t	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259098&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137856	350083799							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336835	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccccc1Cl	InChI=1S/C19H21Cl2N3O3S2/c1-18(2)17(22)24-19(3,10-29(18,26)27)15-13(21)8-14(28-15)16(25)23-9-11-6-4-5-7-12(11)20/h4-8H,9-10H2,1-3H3,(H2,22,24)(H,23,25)/t19-/m0/s1	XADDHUGANNWFSE-IBGZPJMESA-N	259086	US9499502, 22h	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259086	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259086&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094911	350083787							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336836	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1cnn2ccccc12	InChI=1S/C20H22ClN5O3S2/c1-19(2)18(22)25-20(3,11-31(19,28)29)16-13(21)8-15(30-16)17(27)23-9-12-10-24-26-7-5-4-6-14(12)26/h4-8,10H,9,11H2,1-3H3,(H2,22,25)(H,23,27)/t20-/m0/s1	JNGKYIIMRKADEW-FQEVSTJZSA-N	259097	US9499502, 22s	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259097&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137859	350083798							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336837	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccc(cc1)C#N	InChI=1S/C20H21ClN4O3S2/c1-19(2)18(23)25-20(3,11-30(19,27)28)16-14(21)8-15(29-16)17(26)24-10-13-6-4-12(9-22)5-7-13/h4-8H,10-11H2,1-3H3,(H2,23,25)(H,24,26)/t20-/m0/s1	DWVVACGAEVWNTD-FQEVSTJZSA-N	259091	US9499502, 22m	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259091&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095317	350083792							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336838	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1ccsn1	InChI=1S/C16H19ClN4O3S3/c1-15(2)14(18)20-16(3,8-27(15,23)24)12-10(17)6-11(26-12)13(22)19-7-9-4-5-25-21-9/h4-6H,7-8H2,1-3H3,(H2,18,20)(H,19,22)/t16-/m0/s1	FYAVBFLGGRJGPD-INIZCTEOSA-N	259100	US9499502, 22v	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259100&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095282	350083801							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336839	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1cccc(F)c1	InChI=1S/C19H21ClFN3O3S2/c1-18(2)17(22)24-19(3,10-29(18,26)27)15-13(20)8-14(28-15)16(25)23-9-11-5-4-6-12(21)7-11/h4-8H,9-10H2,1-3H3,(H2,22,24)(H,23,25)/t19-/m0/s1	IZWNHKRSHBURGX-IBGZPJMESA-N	259087	US9499502, 22i	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259087	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259087&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094923	350083788							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336840	Cc1ccc(CNC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)nn1	InChI=1S/C18H22ClN5O3S2/c1-10-5-6-11(24-23-10)8-21-15(25)13-7-12(19)14(28-13)18(4)9-29(26,27)17(2,3)16(20)22-18/h5-7H,8-9H2,1-4H3,(H2,20,22)(H,21,25)/t18-/m0/s1	KJSLFEWFUNEBFL-SFHVURJKSA-N	259083	US9499502, 22e	Beta-secretase 2		 550						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259083	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259083&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094900	350083784							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336841	CC#Cc1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H20ClN3O2S2/c1-5-6-12-7-13(10-22-9-12)15-8-14(20)16(26-15)19(4)11-27(24,25)18(2,3)17(21)23-19/h7-10H,11H2,1-4H3,(H2,21,23)/t19-/m0/s1	ZSVOOLBFRHOTBE-IBGZPJMESA-N	259104	US9499502, 25	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259104	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259104&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137858	350083804							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336842	COC(=O)c1ccc([nH]1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1			259106	US9499502, 27	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259106&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138894	350083806							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336843	COc1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C17H20ClN3O3S2/c1-16(2)15(19)21-17(3,9-26(16,22)23)14-12(18)6-13(25-14)10-5-11(24-4)8-20-7-10/h5-8H,9H2,1-4H3,(H2,19,21)/t17-/m0/s1	JFZSGPHIQFBWSB-KRWDZBQOSA-N	259105	US9499502, 26	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259105	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259105&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138893	350083805							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336844	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1cnco1	InChI=1S/C20H20ClN3O3S2/c1-19(2)18(22)24-20(3,10-29(19,25)26)17-14(21)8-16(28-17)13-6-4-5-12(7-13)15-9-23-11-27-15/h4-9,11H,10H2,1-3H3,(H2,22,24)/t20-/m0/s1	FNCZOMKPEIFYCD-FQEVSTJZSA-N	259109	US9499502, 27af::US9499502, 27c	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259109&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137870	350083809							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336845	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C19H19ClN4O3S2/c1-18(2)17(21)23-19(3,9-29(18,25)26)15-13(20)8-14(28-15)11-5-4-6-12(7-11)16-24-22-10-27-16/h4-8,10H,9H2,1-3H3,(H2,21,23)/t19-/m0/s1	ZDJHWLIIQJNZPU-IBGZPJMESA-N	259108	US9499502, 27ae::US9499502, 27b	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259108&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137862	350083808							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336846	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1ccno1	InChI=1S/C20H20ClN3O3S2/c1-19(2)18(22)24-20(3,11-29(19,25)26)17-14(21)10-16(28-17)13-6-4-5-12(9-13)15-7-8-23-27-15/h4-10H,11H2,1-3H3,(H2,22,24)/t20-/m0/s1	WYYHHIJENGURRG-FQEVSTJZSA-N	259138	US9499502, 27ag::US9499502, 27d	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259138&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137861	350083836							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336847	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccc(F)c(c1)C(F)(F)F	InChI=1S/C18H17ClF4N2O2S2/c1-16(2)15(24)25-17(3,8-29(16,26)27)14-11(19)7-13(28-14)9-4-5-12(20)10(6-9)18(21,22)23/h4-7H,8H2,1-3H3,(H2,24,25)/t17-/m0/s1	UCVYQFJYRQSMDS-KRWDZBQOSA-N	259107	US9499502, 27a	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259107&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138966	350083807							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336848	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)C(F)(F)F	InChI=1S/C18H18ClF3N2O2S2/c1-16(2)15(23)24-17(3,9-28(16,25)26)14-12(19)8-13(27-14)10-5-4-6-11(7-10)18(20,21)22/h4-8H,9H2,1-3H3,(H2,23,24)/t17-/m0/s1	AJSWCXADGLKZRO-KRWDZBQOSA-N	259110	US9499502, 27e	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259110&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095169	350083810							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336849	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cncc(Cl)c1	InChI=1S/C16H17Cl2N3O2S2/c1-15(2)14(19)21-16(3,8-25(15,22)23)13-11(18)5-12(24-13)9-4-10(17)7-20-6-9/h4-7H,8H2,1-3H3,(H2,19,21)/t16-/m0/s1	KQDVKEGLTLTSGE-INIZCTEOSA-N	259117	US9499502, 27l	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259117&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095171	350083817							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336850	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cc(Cl)cc(c1)C#N	InChI=1S/C18H17Cl2N3O2S2/c1-17(2)16(22)23-18(3,9-27(17,24)25)15-13(20)7-14(26-15)11-4-10(8-21)5-12(19)6-11/h4-7H,9H2,1-3H3,(H2,22,23)/t18-/m0/s1	GCYNZDJSEILSIV-SFHVURJKSA-N	259124	US9499502, 27s	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259124	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259124&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137871	350083824							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336851	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-n1nccn1	InChI=1S/C19H20ClN5O2S2/c1-18(2)17(21)24-19(3,11-29(18,26)27)16-14(20)10-15(28-16)12-5-4-6-13(9-12)25-22-7-8-23-25/h4-10H,11H2,1-3H3,(H2,21,24)/t19-/m0/s1	YZPRYCLCUSSGIP-IBGZPJMESA-N	259126	US9499502, 27u	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259126&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562044	350083826							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336852	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cnc(o1)-c1ccc(F)cc1	InChI=1S/C20H19ClFN3O3S2/c1-19(2)18(23)25-20(3,10-30(19,26)27)16-13(21)8-15(29-16)14-9-24-17(28-14)11-4-6-12(22)7-5-11/h4-9H,10H2,1-3H3,(H2,23,25)/t20-/m0/s1	OQNJPRIJYBAMSN-FQEVSTJZSA-N	259127	US9499502, 27v	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259127&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095110	350083827							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336853	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cc2ccccc2s1	InChI=1S/C19H19ClN2O2S3/c1-18(2)17(21)22-19(3,10-27(18,23)24)16-12(20)9-15(26-16)14-8-11-6-4-5-7-13(11)25-14/h4-9H,10H2,1-3H3,(H2,21,22)/t19-/m0/s1	NUTDSVYZQCFFMW-IBGZPJMESA-N	259111	US9499502, 27f	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259111&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095166	350083811							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336854	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1csc2ccccc12	InChI=1S/C19H19ClN2O2S3/c1-18(2)17(21)22-19(3,10-27(18,23)24)16-13(20)8-15(26-16)12-9-25-14-7-5-4-6-11(12)14/h4-9H,10H2,1-3H3,(H2,21,22)/t19-/m0/s1	PWRGGAPBUJTCNK-IBGZPJMESA-N	259112	US9499502, 27g	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259112&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562041	350083812							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336855	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccc2ncnn2c1	InChI=1S/C17H18ClN5O2S2/c1-16(2)15(19)22-17(3,8-27(16,24)25)14-11(18)6-12(26-14)10-4-5-13-20-9-21-23(13)7-10/h4-7,9H,8H2,1-3H3,(H2,19,22)/t17-/m0/s1	SGFXQLMACYUJBA-KRWDZBQOSA-N	259122	US9499502, 27q	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259122	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259122&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095152	350083822							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336856	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccn2ncnc2c1	InChI=1S/C17H18ClN5O2S2/c1-16(2)15(19)22-17(3,8-27(16,24)25)14-11(18)7-12(26-14)10-4-5-23-13(6-10)20-9-21-23/h4-7,9H,8H2,1-3H3,(H2,19,22)/t17-/m0/s1	QODXBINQRMTKEF-KRWDZBQOSA-N	259119	US9499502, 27n	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259119&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095167	350083819							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336857	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1coc(n1)-c1ccc(F)cc1	InChI=1S/C20H19ClFN3O3S2/c1-19(2)18(23)25-20(3,10-30(19,26)27)16-13(21)8-15(29-16)14-9-28-17(24-14)11-4-6-12(22)7-5-11/h4-9H,10H2,1-3H3,(H2,23,25)/t20-/m0/s1	KPLRSMOPLYDVRX-FQEVSTJZSA-N	259129	US9499502, 27x	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259129&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095103	350083829							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336858	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cnn2CCCc12	InChI=1S/C17H21ClN4O2S2/c1-16(2)15(19)21-17(3,9-26(16,23)24)14-11(18)7-13(25-14)10-8-20-22-6-4-5-12(10)22/h7-8H,4-6,9H2,1-3H3,(H2,19,21)/t17-/m0/s1	IFGFFDRUYIPINV-KRWDZBQOSA-N	259118	US9499502, 27m	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259118&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562043	350083818							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336859	COc1ncc(cn1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H19ClN4O3S2/c1-15(2)13(18)21-16(3,8-26(15,22)23)12-10(17)5-11(25-12)9-6-19-14(24-4)20-7-9/h5-7H,8H2,1-4H3,(H2,18,21)/t16-/m0/s1	SBWUCYAKBKWXFI-INIZCTEOSA-N	259130	US9499502, 27y	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259130&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095133	350083830							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336860	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccc(C#N)c(c1)C(F)(F)F	InChI=1S/C19H17ClF3N3O2S2/c1-17(2)16(25)26-18(3,9-30(17,27)28)15-13(20)7-14(29-15)10-4-5-11(8-24)12(6-10)19(21,22)23/h4-7H,9H2,1-3H3,(H2,25,26)/t18-/m0/s1	VGUHVSQJHXISSP-SFHVURJKSA-N	259125	US9499502, 27t	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259125	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259125&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137872	350083825							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336861	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(C#N)c1F	InChI=1S/C18H17ClFN3O2S2/c1-17(2)16(22)23-18(3,9-27(17,24)25)15-12(19)7-13(26-15)11-6-4-5-10(8-21)14(11)20/h4-7H,9H2,1-3H3,(H2,22,23)/t18-/m0/s1	PJNRJSZFYRJRHR-SFHVURJKSA-N	259131	US9499502, 27z	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259131	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259131&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137873	350083831							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336862	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(OC(F)(F)F)c1	InChI=1S/C18H18ClF3N2O3S2/c1-16(2)15(23)24-17(3,9-29(16,25)26)14-12(19)8-13(28-14)10-5-4-6-11(7-10)27-18(20,21)22/h4-8H,9H2,1-3H3,(H2,23,24)/t17-/m0/s1	COUKOOQXQNPKHL-KRWDZBQOSA-N	259113	US9499502, 27h	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259113&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562042	350083813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336863	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccc(F)c(c1)C#N	InChI=1S/C18H17ClFN3O2S2/c1-17(2)16(22)23-18(3,9-27(17,24)25)15-12(19)7-14(26-15)10-4-5-13(20)11(6-10)8-21/h4-7H,9H2,1-3H3,(H2,22,23)/t18-/m0/s1	DQEIAWMJBGGSNK-SFHVURJKSA-N	259115	US9499502, 27j	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259115&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137869	350083815							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336864	COc1cncc(n1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H19ClN4O3S2/c1-15(2)14(18)21-16(3,8-26(15,22)23)13-9(17)5-11(25-13)10-6-19-7-12(20-10)24-4/h5-7H,8H2,1-4H3,(H2,18,21)/t16-/m0/s1	PRTBWAPOQFKMAG-INIZCTEOSA-N	259128	US9499502, 27w	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259128&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095114	350083828							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336865	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(OC(F)F)c1	InChI=1S/C18H19ClF2N2O3S2/c1-17(2)15(22)23-18(3,9-28(17,24)25)14-12(19)8-13(27-14)10-5-4-6-11(7-10)26-16(20)21/h4-8,16H,9H2,1-3H3,(H2,22,23)/t18-/m0/s1	QFBUHTOCJOKOCC-SFHVURJKSA-N	259120	US9499502, 27o	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259120&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095297	350083820							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336866	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1ccc2nncn2c1	InChI=1S/C17H18ClN5O2S2/c1-16(2)15(19)21-17(3,8-27(16,24)25)14-11(18)6-12(26-14)10-4-5-13-22-20-9-23(13)7-10/h4-7,9H,8H2,1-3H3,(H2,19,21)/t17-/m0/s1	VKWXLTRHPBDUBR-KRWDZBQOSA-N	259121	US9499502, 27p	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259121&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095093	350083821							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336867	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cc(F)cc(F)c1	InChI=1S/C17H17ClF2N2O2S2/c1-16(2)15(21)22-17(3,8-26(16,23)24)14-12(18)7-13(25-14)9-4-10(19)6-11(20)5-9/h4-7H,8H2,1-3H3,(H2,21,22)/t17-/m0/s1	NZCUOXBHJDUNQP-KRWDZBQOSA-N	259114	US9499502, 27i	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259114&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095170	350083814							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336868	COCCn1cc(cn1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C17H23ClN4O3S2/c1-16(2)15(19)21-17(3,10-27(16,23)24)14-12(18)7-13(26-14)11-8-20-22(9-11)5-6-25-4/h7-9H,5-6,10H2,1-4H3,(H2,19,21)/t17-/m0/s1	LISSBZZHEPEKQB-KRWDZBQOSA-N	259123	US9499502, 27r	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259123&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095104	350083823							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336869	COc1cc(ccn1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C17H20ClN3O3S2/c1-16(2)15(19)21-17(3,9-26(16,22)23)14-11(18)8-12(25-14)10-5-6-20-13(7-10)24-4/h5-8H,9H2,1-4H3,(H2,19,21)/t17-/m0/s1	VLFNKIUBFBAMHI-KRWDZBQOSA-N	259116	US9499502, 27k	Beta-secretase 2		 600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259116	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259116&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095165	350083816							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336870	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1cnco1	InChI=1S/C20H20ClN3O3S2/c1-19(2)18(22)24-20(3,10-29(19,25)26)17-14(21)8-16(28-17)13-6-4-5-12(7-13)15-9-23-11-27-15/h4-9,11H,10H2,1-3H3,(H2,22,24)/t20-/m0/s1	FNCZOMKPEIFYCD-FQEVSTJZSA-N	259109	US9499502, 27af::US9499502, 27c	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259109&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137870	350083809							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336871	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cc(F)cc(c1)-c1cnco1	InChI=1S/C20H19ClFN3O3S2/c1-19(2)18(23)25-20(3,9-30(19,26)27)17-14(21)7-16(29-17)12-4-11(5-13(22)6-12)15-8-24-10-28-15/h4-8,10H,9H2,1-3H3,(H2,23,25)/t20-/m0/s1	OMNZSVLJRZCPHO-FQEVSTJZSA-N	259132	US9499502, 27aa	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259132&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095101	350083832							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336872	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C19H18ClFN4O3S2/c1-18(2)17(22)24-19(3,8-30(18,26)27)15-13(20)7-14(29-15)10-4-11(6-12(21)5-10)16-25-23-9-28-16/h4-7,9H,8H2,1-3H3,(H2,22,24)/t19-/m0/s1	RNIVXENTTYYSQY-IBGZPJMESA-N	259133	US9499502, 27ab	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259133&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095107	350083833							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336873	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1ccno1	InChI=1S/C20H20ClN3O3S2/c1-19(2)18(22)24-20(3,11-29(19,25)26)17-14(21)10-16(28-17)13-6-4-5-12(9-13)15-7-8-23-27-15/h4-10H,11H2,1-3H3,(H2,22,24)/t20-/m0/s1	WYYHHIJENGURRG-FQEVSTJZSA-N	259138	US9499502, 27ag::US9499502, 27d	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259138&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137861	350083836							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336874	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)-c1ncco1	InChI=1S/C19H19ClN4O3S2/c1-18(2)17(21)24-19(3,10-29(18,25)26)15-13(20)7-14(28-15)11-6-12(9-22-8-11)16-23-4-5-27-16/h4-9H,10H2,1-3H3,(H2,21,24)/t19-/m0/s1	IOBPTURJEQXHAO-IBGZPJMESA-N	259135	US9499502, 27ad	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259135&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095130	350083835							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336875	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)-c1cnco1	InChI=1S/C19H19ClN4O3S2/c1-18(2)17(21)24-19(3,9-29(18,25)26)16-13(20)5-15(28-16)12-4-11(6-22-7-12)14-8-23-10-27-14/h4-8,10H,9H2,1-3H3,(H2,21,24)/t19-/m0/s1	FXGSWXHWUCOIPC-IBGZPJMESA-N	259134	US9499502, 27ac	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259134&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095127	350083834							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336876	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(cs1)-c1cncc(c1)-c1ncco1	InChI=1S/C19H20N4O3S2/c1-18(2)17(20)23-19(3,11-28(18,24)25)15-7-14(10-27-15)12-6-13(9-21-8-12)16-22-4-5-26-16/h4-10H,11H2,1-3H3,(H2,20,23)/t19-/m0/s1	LYZMIZDPAYYUDX-IBGZPJMESA-N	259142	US9499502, 27ak	Beta-secretase 2		 88						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259142&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562045	350083840							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336877	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(cs1)-c1cccc(c1)-c1nnco1	InChI=1S/C19H20N4O3S2/c1-18(2)17(20)22-19(3,10-28(18,24)25)15-8-14(9-27-15)12-5-4-6-13(7-12)16-23-21-11-26-16/h4-9,11H,10H2,1-3H3,(H2,20,22)/t19-/m0/s1	RPWIOZZDPSZHDG-IBGZPJMESA-N	259139	US9499502, 27ah	Beta-secretase 2		 88						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259139&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095154	350083837							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336878	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(cs1)-c1cncc(c1)-c1cnco1	InChI=1S/C19H20N4O3S2/c1-18(2)17(20)23-19(3,10-28(18,24)25)16-5-14(9-27-16)12-4-13(7-21-6-12)15-8-22-11-26-15/h4-9,11H,10H2,1-3H3,(H2,20,23)/t19-/m0/s1	NHMWXOQJSMLEEZ-IBGZPJMESA-N	259143	US9499502, 27al	Beta-secretase 2		 88						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259143&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095250	350083841							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336879	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(cs1)-c1cccc(c1)-c1cnco1	InChI=1S/C20H21N3O3S2/c1-19(2)18(21)23-20(3,11-28(19,24)25)17-8-15(10-27-17)13-5-4-6-14(7-13)16-9-22-12-26-16/h4-10,12H,11H2,1-3H3,(H2,21,23)/t20-/m0/s1	GKSQYLRNBXGOPI-FQEVSTJZSA-N	259140	US9499502, 27ai	Beta-secretase 2		 88						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259140&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095229	350083838							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336880	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(cs1)-c1cccc(c1)-c1ccno1	InChI=1S/C20H21N3O3S2/c1-19(2)18(21)23-20(3,12-28(19,24)25)17-10-15(11-27-17)13-5-4-6-14(9-13)16-7-8-22-26-16/h4-11H,12H2,1-3H3,(H2,21,23)/t20-/m0/s1	IGAJQVCRMDMLDI-FQEVSTJZSA-N	259141	US9499502, 27aj	Beta-secretase 2		 88						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259141&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095230	350083839							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336881	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(cs1)-c1cc(F)cc(c1)-c1cnco1	InChI=1S/C20H20FN3O3S2/c1-19(2)18(22)24-20(3,10-29(19,25)26)17-7-14(9-28-17)12-4-13(6-15(21)5-12)16-8-23-11-27-16/h4-9,11H,10H2,1-3H3,(H2,22,24)/t20-/m0/s1	QHKCSFFXIOUWCT-FQEVSTJZSA-N	259144	US9499502, 27am	Beta-secretase 2		 88						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259144&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095236	350083842							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336882	COc1cccc2cc([nH]c12)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1			259145	US9499502, 27an	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259145&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137875	350083843							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336883	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1cccc(c1)-c1ncon1	InChI=1S/C19H19FN4O3S2/c1-18(2)17(21)23-19(3,9-29(18,25)26)15-13(20)8-14(28-15)11-5-4-6-12(7-11)16-22-10-27-24-16/h4-8,10H,9H2,1-3H3,(H2,21,23)/t19-/m0/s1	WRHDLTRRSBQGAL-IBGZPJMESA-N	259146	US9499502, 27ao	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259146&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095172	350083844							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336884	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C18H18FN3O2S2/c1-17(2)16(21)22-18(3,10-26(17,23)24)15-13(19)8-14(25-15)12-6-4-5-11(7-12)9-20/h4-8H,10H2,1-3H3,(H2,21,22)/t18-/m0/s1	YVKYWWUIVQDUMS-SFHVURJKSA-N	259148	US9499502, 27aq	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259148&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137879	350083846							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336885	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1cc(F)cc(c1)-c1cnco1	InChI=1S/C20H19F2N3O3S2/c1-19(2)18(23)25-20(3,9-30(19,26)27)17-14(22)7-16(29-17)12-4-11(5-13(21)6-12)15-8-24-10-28-15/h4-8,10H,9H2,1-3H3,(H2,23,25)/t20-/m0/s1	DHQDSSRLQIQPHQ-FQEVSTJZSA-N	259151	US9499502, 27at	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259151&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562469	350083849							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336886	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1cccc(c1)-c1nnco1	InChI=1S/C19H19FN4O3S2/c1-18(2)17(21)23-19(3,9-29(18,25)26)15-13(20)8-14(28-15)11-5-4-6-12(7-11)16-24-22-10-27-16/h4-8,10H,9H2,1-3H3,(H2,21,23)/t19-/m0/s1	VJWYGQPOSIPOGQ-IBGZPJMESA-N	259149	US9499502, 27ar	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259149&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137880	350083847							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336887	Cc1nnc(o1)-c1ccc(F)c(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H20F2N4O3S2/c1-10-25-26-17(29-10)11-5-6-13(21)12(7-11)15-8-14(22)16(30-15)20(4)9-31(27,28)19(2,3)18(23)24-20/h5-8H,9H2,1-4H3,(H2,23,24)/t20-/m0/s1	YRNALOVKNPHLOX-FQEVSTJZSA-N	259155	US9499502, 27ax	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259155&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137884	350083853							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336888	COc1cncc(n1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H19FN4O3S2/c1-15(2)14(18)21-16(3,8-26(15,22)23)13-9(17)5-11(25-13)10-6-19-7-12(20-10)24-4/h5-7H,8H2,1-4H3,(H2,18,21)/t16-/m0/s1	OJZNAHLTKZTFGW-INIZCTEOSA-N	259152	US9499502, 27au	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259152&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137881	350083850							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336889	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1cncc(c1)C#N	InChI=1S/C17H17FN4O2S2/c1-16(2)15(20)22-17(3,9-26(16,23)24)14-12(18)5-13(25-14)11-4-10(6-19)7-21-8-11/h4-5,7-8H,9H2,1-3H3,(H2,20,22)/t17-/m0/s1	HABGAUGNALXBGR-KRWDZBQOSA-N	259147	US9499502, 27ap	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259147&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137877	350083845							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335553	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(C)N=C(N)OCC1(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-5-10(6-22)7-24-13(9)15(28)26-12-4-3-11(19)14(25-12)17(2)18(20,21)8-29-16(23)27-17/h3-5,7H,8H2,1-2H3,(H2,23,27)(H,25,26,28)/t17-/m1/s1	ISXCJKRNXUQSFB-QGZVFWFLSA-N	186047	US9163011, 1	Beta-secretase 2			 66					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186047&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273895	315658582							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335554	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C17H12ClF3N6O2/c1-16(17(20,21)7-29-15(23)27-16)13-10(19)2-3-11(25-13)26-14(28)12-9(18)4-8(5-22)6-24-12/h2-4,6H,7H2,1H3,(H2,23,27)(H,25,26,28)/t16-/m1/s1	XZRLHXIFWZKMCO-MRXNPFEDSA-N	186048	US9163011, 2	Beta-secretase 2			 71					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186048&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274019	315658583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335555	CC1(C)OC(N)=N[C@](C)(c2nc(NC(=O)c3ncc(cc3Cl)C#N)ccc2F)C1(F)F	InChI=1S/C19H16ClF3N6O2/c1-17(2)19(22,23)18(3,29-16(25)31-17)14-11(21)4-5-12(27-14)28-15(30)13-10(20)6-9(7-24)8-26-13/h4-6,8H,1-3H3,(H2,25,29)(H,27,28,30)/t18-/m1/s1	VZKPBWICQCZMIB-GOSISDBHSA-N	186049	US9163011, 3	Beta-secretase 2			 140					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186049&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274016	315658584							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335556	COCC[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C20H19F3N6O3/c1-11-7-12(8-24)9-26-15(11)17(30)28-14-4-3-13(21)16(27-14)19(5-6-31-2)20(22,23)10-32-18(25)29-19/h3-4,7,9H,5-6,10H2,1-2H3,(H2,25,29)(H,27,28,30)/t19-/m1/s1	PSPGXNMAHYIESQ-LJQANCHMSA-N	186050	US9163011, 4	Beta-secretase 2			 580					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186050&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273947	315658585							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335557	COCC[C@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C20H19F3N6O3/c1-11-7-12(8-24)9-26-15(11)17(30)28-14-4-3-13(21)16(27-14)19(5-6-31-2)20(22,23)10-32-18(25)29-19/h3-4,7,9H,5-6,10H2,1-2H3,(H2,25,29)(H,27,28,30)/t19-/m0/s1	PSPGXNMAHYIESQ-IBGZPJMESA-N	186051	US9163011, 5	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186051&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273877	315658586							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335558	COCC[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C19H16ClF6N5O3/c1-33-5-4-17(18(22,23)8-34-16(27)31-17)14-11(21)2-3-12(29-14)30-15(32)13-10(20)6-9(7-28-13)19(24,25)26/h2-3,6-7H,4-5,8H2,1H3,(H2,27,31)(H,29,30,32)/t17-/m1/s1	WPEMUUFTBABGBW-QGZVFWFLSA-N	186052	US9163011, 6	Beta-secretase 2			 6600					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186052&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529211	315658587							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335559	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C17H12ClF6N5O2/c1-15(16(20,21)6-31-14(25)29-15)12-9(19)2-3-10(27-12)28-13(30)11-8(18)4-7(5-26-11)17(22,23)24/h2-5H,6H2,1H3,(H2,25,29)(H,27,28,30)/t15-/m1/s1	LOLRSSGXRIPFCB-OAHLLOKOSA-N	186053	US9163011, 7	Beta-secretase 2			 290					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186053&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529262	315658588							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335560	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(nc2N)C(F)(F)F)ccc1F	InChI=1S/C16H13F6N7O2/c1-14(15(18,19)5-31-13(24)29-14)10-6(17)2-3-8(27-10)28-12(30)9-11(23)26-7(4-25-9)16(20,21)22/h2-4H,5H2,1H3,(H2,23,26)(H2,24,29)(H,27,28,30)/t14-/m1/s1	WVFHQWCQXOAIHG-CQSZACIVSA-N	186054	US9163011, 8	Beta-secretase 2			 1400					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186054&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529263	315658589							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335561	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C16H12Cl2F3N5O2/c1-15(16(20,21)6-28-14(22)26-15)12-9(19)2-3-10(24-12)25-13(27)11-8(18)4-7(17)5-23-11/h2-5H,6H2,1H3,(H2,22,26)(H,24,25,27)/t15-/m1/s1	CGFNKFZCIRBOAD-OAHLLOKOSA-N	186055	US9163011, 9	Beta-secretase 2			 4					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186055&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273898	315658590							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335562	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCC(F)(F)F)nc2N)ccc1F	InChI=1S/C17H15F6N7O3/c1-15(16(19,20)5-33-14(25)30-15)11-7(18)2-3-8(27-11)28-13(31)10-12(24)29-9(4-26-10)32-6-17(21,22)23/h2-4H,5-6H2,1H3,(H2,24,29)(H2,25,30)(H,27,28,31)/t15-/m1/s1	LTIOGWHOZDPVCK-OAHLLOKOSA-N	186056	US9163011, 10	Beta-secretase 2			 3800					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186056&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529264	315658591							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335563	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCC(F)F)nc2N)ccc1F	InChI=1S/C17H16F5N7O3/c1-16(17(21,22)6-32-15(24)29-16)12-7(18)2-3-9(26-12)27-14(30)11-13(23)28-10(4-25-11)31-5-8(19)20/h2-4,8H,5-6H2,1H3,(H2,23,28)(H2,24,29)(H,26,27,30)/t16-/m1/s1	FKUWIXCLOXGDMB-MRXNPFEDSA-N	186057	US9163011, 11	Beta-secretase 2			 2900					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186057&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529265	315658592							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335564	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCCCF)nc2N)ccc1F	InChI=1S/C18H19F4N7O3/c1-17(18(21,22)8-32-16(24)29-17)13-9(20)3-4-10(26-13)27-15(30)12-14(23)28-11(7-25-12)31-6-2-5-19/h3-4,7H,2,5-6,8H2,1H3,(H2,23,28)(H2,24,29)(H,26,27,30)/t17-/m1/s1	PCWNWAKTIVCZNM-QGZVFWFLSA-N	186058	US9163011, 12	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186058&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529266	315658593							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335565	COc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(C)c1	InChI=1S/C18H18F3N5O3/c1-9-6-10(28-3)7-23-13(9)15(27)25-12-5-4-11(19)14(24-12)17(2)18(20,21)8-29-16(22)26-17/h4-7H,8H2,1-3H3,(H2,22,26)(H,24,25,27)/t17-/m1/s1	QOCIHSUXWNYFHI-QGZVFWFLSA-N	186059	US9163011, 13	Beta-secretase 2			 93					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186059&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273903	315658594							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335566	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCF)nc2N)ccc1F	InChI=1S/C16H15F4N7O3/c1-15(16(19,20)5-29-14(22)27-15)11-7(18)2-3-8(24-11)25-13(28)10-12(21)26-9(4-23-10)30-6-17/h2-4H,5-6H2,1H3,(H2,21,26)(H2,22,27)(H,24,25,28)/t15-/m1/s1	FMYPBFZNJZIDKT-OAHLLOKOSA-N	186061	US9163011, 15	Beta-secretase 2			 730					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186061&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273969	315658596							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335567	COCCOc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(N)n1	InChI=1S/C18H20F3N7O4/c1-17(18(20,21)8-32-16(23)28-17)13-9(19)3-4-10(25-13)26-15(29)12-14(22)27-11(7-24-12)31-6-5-30-2/h3-4,7H,5-6,8H2,1-2H3,(H2,22,27)(H2,23,28)(H,25,26,29)/t17-/m1/s1	YYABTMDXDSJCFD-QGZVFWFLSA-N	186062	US9163011, 16	Beta-secretase 2			 8900					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186062&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529316	315658597							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335568	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2N)C#CCO)ccc1F	InChI=1S/C19H17F3N6O3/c1-18(19(21,22)9-31-17(24)28-18)15-11(20)4-5-13(26-15)27-16(30)14-12(23)7-10(8-25-14)3-2-6-29/h4-5,7-8,29H,6,9,23H2,1H3,(H2,24,28)(H,26,27,30)/t18-/m1/s1	LPHMJKHHQPFBCQ-GOSISDBHSA-N	186063	US9163011, 17	Beta-secretase 2			 8200					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186063	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186063&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529317	315658598							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335569	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(F)cc2N)ccc1F	InChI=1S/C16H14F4N6O2/c1-15(16(19,20)6-28-14(22)26-15)12-8(18)2-3-10(24-12)25-13(27)11-9(21)4-7(17)5-23-11/h2-5H,6,21H2,1H3,(H2,22,26)(H,24,25,27)/t15-/m1/s1	XNUKXZBBFWKBDZ-OAHLLOKOSA-N	186064	US9163011, 18	Beta-secretase 2			 120					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186064	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186064&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274053	315658599							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335570	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(Cl)cc2N)ccc1F	InChI=1S/C16H14ClF3N6O2/c1-15(16(19,20)6-28-14(22)26-15)12-8(18)2-3-10(24-12)25-13(27)11-9(21)4-7(17)5-23-11/h2-5H,6,21H2,1H3,(H2,22,26)(H,24,25,27)/t15-/m1/s1	XSIPOULVCGGORY-OAHLLOKOSA-N	186065	US9163011, 19	Beta-secretase 2			 48					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186065	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186065&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274056	315658600							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335571	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncccc2Cl)ccc1F	InChI=1S/C16H13ClF3N5O2/c1-15(16(19,20)7-27-14(21)25-15)12-9(18)4-5-10(23-12)24-13(26)11-8(17)3-2-6-22-11/h2-6H,7H2,1H3,(H2,21,25)(H,23,24,26)/t15-/m1/s1	MQFTZDVMSMFRAU-OAHLLOKOSA-N	186066	US9163011, 20	Beta-secretase 2			 95					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186066&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71271537	315658601							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335572	COCC#Cc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(Cl)c1	InChI=1S/C20H17ClF3N5O3/c1-19(20(23,24)10-32-18(25)29-19)16-13(22)5-6-14(27-16)28-17(30)15-12(21)8-11(9-26-15)4-3-7-31-2/h5-6,8-9H,7,10H2,1-2H3,(H2,25,29)(H,27,28,30)/t19-/m1/s1	BMPSPTZUQDKEEP-LJQANCHMSA-N	186067	US9163011, 21	Beta-secretase 2			 840					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186067&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529373	315658602							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335573	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(nc2N)C(F)F)ccc1F	InChI=1S/C16H14F5N7O2/c1-15(16(20,21)5-30-14(23)28-15)10-6(17)2-3-8(26-10)27-13(29)9-12(22)25-7(4-24-9)11(18)19/h2-4,11H,5H2,1H3,(H2,22,25)(H2,23,28)(H,26,27,29)/t15-/m1/s1	VJQYWRACFCYUPR-OAHLLOKOSA-N	186068	US9163011, 22	Beta-secretase 2			 580					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186068&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273961	315658603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335574	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCCCl)nc2N)ccc1F	InChI=1S/C17H17ClF3N7O3/c1-16(17(20,21)7-31-15(23)28-16)12-8(19)2-3-9(25-12)26-14(29)11-13(22)27-10(6-24-11)30-5-4-18/h2-3,6H,4-5,7H2,1H3,(H2,22,27)(H2,23,28)(H,25,26,29)/t16-/m1/s1	UWVJOGWOKXGBMT-MRXNPFEDSA-N	186069	US9163011, 23	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186069&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529374	315658604							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335575	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCC(F)F)cc2Cl)ccc1F	InChI=1S/C18H15ClF5N5O3/c1-17(18(23,24)7-32-16(25)29-17)14-10(20)2-3-12(27-14)28-15(30)13-9(19)4-8(5-26-13)31-6-11(21)22/h2-5,11H,6-7H2,1H3,(H2,25,29)(H,27,28,30)/t17-/m1/s1	SYFKAGCUUZFBGJ-QGZVFWFLSA-N	186070	US9163011, 24	Beta-secretase 2			 4500					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186070&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529375	315658605							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335576	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCCF)nc2N)ccc1F	InChI=1S/C17H17F4N7O3/c1-16(17(20,21)7-31-15(23)28-16)12-8(19)2-3-9(25-12)26-14(29)11-13(22)27-10(6-24-11)30-5-4-18/h2-3,6H,4-5,7H2,1H3,(H2,22,27)(H2,23,28)(H,25,26,29)/t16-/m1/s1	HTVUCPUQMUSURS-MRXNPFEDSA-N	186071	US9163011, 25	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186071&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529423	315658606							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335577	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCF)cc2Cl)ccc1F	InChI=1S/C17H14ClF4N5O3/c1-16(17(21,22)6-29-15(23)27-16)13-10(20)2-3-11(25-13)26-14(28)12-9(18)4-8(5-24-12)30-7-19/h2-5H,6-7H2,1H3,(H2,23,27)(H,25,26,28)/t16-/m1/s1	UXWJPYCELGAIGP-MRXNPFEDSA-N	186072	US9163011, 26	Beta-secretase 2			 27					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186072	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186072&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273880	315658607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335578	CCOc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(Cl)c1	InChI=1S/C18H17ClF3N5O3/c1-3-29-9-6-10(19)13(24-7-9)15(28)26-12-5-4-11(20)14(25-12)17(2)18(21,22)8-30-16(23)27-17/h4-7H,3,8H2,1-2H3,(H2,23,27)(H,25,26,28)/t17-/m1/s1	NCAGWNFSRXNJDL-QGZVFWFLSA-N	186073	US9163011, 27	Beta-secretase 2			 420					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186073&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273878	315658608							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335579	COCCc1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(N)n1	InChI=1S/C18H20F3N7O3/c1-17(18(20,21)8-31-16(23)28-17)13-10(19)3-4-11(26-13)27-15(29)12-14(22)25-9(7-24-12)5-6-30-2/h3-4,7H,5-6,8H2,1-2H3,(H2,22,25)(H2,23,28)(H,26,27,29)/t17-/m1/s1	RZPYITONBLAMAN-QGZVFWFLSA-N	186074	US9163011, 29	Beta-secretase 2			 5600					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186074&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529425	315658609							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335580	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C15H12ClF5N6O2/c1-14(15(20,21)5-29-13(22)25-14)10-7(17)2-3-8(23-10)24-11(28)9-6(16)4-27(26-9)12(18)19/h2-4,12H,5H2,1H3,(H2,22,25)(H,23,24,28)/t14-/m1/s1	PUANGZKWYIUWGX-CQSZACIVSA-N	186075	US9163011, 30	Beta-secretase 2			 7					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186075&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529426	315658610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335581	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2nccnc2N)ccc1F	InChI=1S/C15H14F3N7O2/c1-14(15(17,18)6-27-13(20)25-14)10-7(16)2-3-8(23-10)24-12(26)9-11(19)22-5-4-21-9/h2-5H,6H2,1H3,(H2,19,22)(H2,20,25)(H,23,24,26)/t14-/m1/s1	YJPIAQRBQQFOPC-CQSZACIVSA-N	186076	US9163011, 31	Beta-secretase 2			 490					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186076&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274021	315658611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335582	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#CCO)ccc1F	InChI=1S/C19H15ClF3N5O3/c1-18(19(22,23)9-31-17(24)28-18)15-12(21)4-5-13(26-15)27-16(30)14-11(20)7-10(8-25-14)3-2-6-29/h4-5,7-8,29H,6,9H2,1H3,(H2,24,28)(H,26,27,30)/t18-/m1/s1	GNNDIRZJLBDRCO-GOSISDBHSA-N	186077	US9163011, 32	Beta-secretase 2			 930					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186077	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186077&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274015	315658612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335583	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2N)C(F)F)ccc1F	InChI=1S/C17H15F5N6O2/c1-16(17(21,22)6-30-15(24)28-16)12-8(18)2-3-10(26-12)27-14(29)11-9(23)4-7(5-25-11)13(19)20/h2-5,13H,6,23H2,1H3,(H2,24,28)(H,26,27,29)/t16-/m1/s1	WFIZWFCJKHASMD-MRXNPFEDSA-N	186078	US9163011, 33	Beta-secretase 2			 260					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186078&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274020	315658613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335584	CC(F)(F)c1nc(N)c(nc1Cl)C(=O)Nc1ccc(F)c(n1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C17H15ClF5N7O2/c1-15(17(22,23)5-32-14(25)30-15)9-6(19)3-4-7(26-9)27-13(31)8-12(24)29-10(11(18)28-8)16(2,20)21/h3-4H,5H2,1-2H3,(H2,24,29)(H2,25,30)(H,26,27,31)/t15-/m1/s1	INTWBADHVOGJEU-OAHLLOKOSA-N	186079	US9163011, 34	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186079&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529464	315658614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335585	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C17H13F3N6O2/c1-16(17(19,20)8-28-15(22)26-16)13-10(18)3-5-12(24-13)25-14(27)11-4-2-9(6-21)7-23-11/h2-5,7H,8H2,1H3,(H2,22,26)(H,24,25,27)/t16-/m1/s1	ZWUWGLTVWPXQQS-MRXNPFEDSA-N	186080	US9163011, 35	Beta-secretase 2			 260					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186080	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186080&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529465	315658615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
335586	CC(F)(F)c1cnc(C(=O)Nc2ccc(F)c(n2)[C@@]2(C)N=C(N)OCC2(F)F)c(N)n1	InChI=1S/C17H16F5N7O2/c1-15(17(21,22)6-31-14(24)29-15)11-7(18)3-4-9(27-11)28-13(30)10-12(23)26-8(5-25-10)16(2,19)20/h3-5H,6H2,1-2H3,(H2,23,26)(H2,24,29)(H,27,28,30)/t15-/m1/s1	GEYFZFDMDJIWCM-OAHLLOKOSA-N	186082	US9163011, 37	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2Z60MV1		aid1801753	US9163011	Lueoend, RM; Machauer, R; Rueeger, H; Veenstra, SJ	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186082	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186082&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273879	315658617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336890	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1ccnc(c1)C1CC1	InChI=1S/C19H22FN3O2S2/c1-18(2)17(21)23-19(3,10-27(18,24)25)16-13(20)9-15(26-16)12-6-7-22-14(8-12)11-4-5-11/h6-9,11H,4-5,10H2,1-3H3,(H2,21,23)/t19-/m0/s1	XQINVEQEBMSYFJ-IBGZPJMESA-N	259153	US9499502, 27av	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259153&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137882	350083851							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336891	Cc1noc(n1)-c1cccc(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H21FN4O3S2/c1-11-23-17(28-25-11)13-7-5-6-12(8-13)15-9-14(21)16(29-15)20(4)10-30(26,27)19(2,3)18(22)24-20/h5-9H,10H2,1-4H3,(H2,22,24)/t20-/m0/s1	UXEFOFZBMMHKCN-FQEVSTJZSA-N	259154	US9499502, 27aw	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259154&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137883	350083852							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336892	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1cncc(c1)-c1nnco1	InChI=1S/C18H18FN5O3S2/c1-17(2)16(20)23-18(3,8-29(17,25)26)14-12(19)5-13(28-14)10-4-11(7-21-6-10)15-24-22-9-27-15/h4-7,9H,8H2,1-3H3,(H2,20,23)/t18-/m0/s1	FLJWYEBSJWSVTH-SFHVURJKSA-N	259157	US9499502, 27az	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259157&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137886	350083855							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336893	Cc1nnc(o1)-c1cccc(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H21FN4O3S2/c1-11-24-25-17(28-11)13-7-5-6-12(8-13)15-9-14(21)16(29-15)20(4)10-30(26,27)19(2,3)18(22)23-20/h5-9H,10H2,1-4H3,(H2,22,23)/t20-/m0/s1	OEDPDEVDXFBJLG-FQEVSTJZSA-N	259156	US9499502, 27ay	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259156&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137885	350083854							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336894	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C19H18F2N4O3S2/c1-18(2)17(22)24-19(3,8-30(18,26)27)15-13(21)7-14(29-15)10-4-11(6-12(20)5-10)16-25-23-9-28-16/h4-7,9H,8H2,1-3H3,(H2,22,24)/t19-/m0/s1	NDMCQAYJSUCCCI-IBGZPJMESA-N	259150	US9499502, 27as	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259150&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562468	350083848							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336895	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(F)cc1	InChI=1S/C19H18ClFN4O3S2/c1-18(2)17(22)23-19(3,9-30(18,26)27)14-12(20)8-13(29-14)16-25-24-15(28-16)10-4-6-11(21)7-5-10/h4-8H,9H2,1-3H3,(H2,22,23)/t19-/m0/s1	PRSIIYYVGLNENM-IBGZPJMESA-N	259159	US9499502, 27bb	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259159&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137889	350083857							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336896	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C19H18Cl2N4O3S2/c1-18(2)17(22)23-19(3,9-30(18,26)27)14-12(21)8-13(29-14)16-25-24-15(28-16)10-4-6-11(20)7-5-10/h4-8H,9H2,1-3H3,(H2,22,23)/t19-/m0/s1	WITGPFFAZPOXBX-IBGZPJMESA-N	259160	US9499502, 27bc	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259160&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137890	350083858							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336897	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C19H18ClFN4O3S2/c1-18(2)17(22)23-19(3,9-30(18,26)27)14-12(21)8-13(29-14)16-25-24-15(28-16)10-4-6-11(20)7-5-10/h4-8H,9H2,1-3H3,(H2,22,23)/t19-/m0/s1	QWZKAFRDKLLVGW-IBGZPJMESA-N	259163	US9499502, 27bf	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259163&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562146	350083861							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336898	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1nnc(o1)-c1ccc(F)cc1	InChI=1S/C19H18F2N4O3S2/c1-18(2)17(22)23-19(3,9-30(18,26)27)14-12(21)8-13(29-14)16-25-24-15(28-16)10-4-6-11(20)7-5-10/h4-8H,9H2,1-3H3,(H2,22,23)/t19-/m0/s1	QESFFQVWHNGJCH-IBGZPJMESA-N	259164	US9499502, 27bg	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259164&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137892	350083862							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336899	COc1ccc(cc1)-c1nnc(o1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H21FN4O4S2/c1-19(2)18(22)23-20(3,10-31(19,26)27)15-13(21)9-14(30-15)17-25-24-16(29-17)11-5-7-12(28-4)8-6-11/h5-9H,10H2,1-4H3,(H2,22,23)/t20-/m0/s1	FWPGRDCZUYDDPP-FQEVSTJZSA-N	259165	US9499502, 27bh	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259165&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138951	350083863							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336900	COc1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H21ClN4O4S2/c1-19(2)18(22)23-20(3,10-31(19,26)27)15-13(21)9-14(30-15)17-25-24-16(29-17)11-5-7-12(28-4)8-6-11/h5-9H,10H2,1-4H3,(H2,22,23)/t20-/m0/s1	JUKYFIZDFKJKSL-FQEVSTJZSA-N	259161	US9499502, 27bd	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259161	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259161&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138924	350083859							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336901	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1F)-c1nnc(o1)-c1ccc(cc1)C#N	InChI=1S/C20H18FN5O3S2/c1-19(2)18(23)24-20(3,10-31(19,27)28)15-13(21)8-14(30-15)17-26-25-16(29-17)12-6-4-11(9-22)5-7-12/h4-8H,10H2,1-3H3,(H2,23,24)/t20-/m0/s1	SXQFRCCYSJSLCF-FQEVSTJZSA-N	259166	US9499502, 27bi	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259166&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138925	350083864							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336902	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)C#N	InChI=1S/C20H18ClN5O3S2/c1-19(2)18(23)24-20(3,10-31(19,27)28)15-13(21)8-14(30-15)17-26-25-16(29-17)12-6-4-11(9-22)5-7-12/h4-8H,10H2,1-3H3,(H2,23,24)/t20-/m0/s1	ZRANACLWRPQMHF-FQEVSTJZSA-N	259162	US9499502, 27be	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259162&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138895	350083860							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336903	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1nnc(o1)-c1ccccc1	InChI=1S/C19H19ClN4O3S2/c1-18(2)17(21)22-19(3,10-29(18,25)26)14-12(20)9-13(28-14)16-24-23-15(27-16)11-7-5-4-6-8-11/h4-9H,10H2,1-3H3,(H2,21,22)/t19-/m0/s1	ZLRJDOVWMSHYJM-IBGZPJMESA-N	259158	US9499502, 27ba	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259158&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137887	350083856							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336904	COc1cccc(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)[C@](C)(CC(F)(F)F)C(=N)N1	InChI=1S/C19H20F4N2O3S2/c1-17(10-30(26,27)18(2,16(24)25-17)9-19(21,22)23)15-13(20)8-14(29-15)11-5-4-6-12(7-11)28-3/h4-8H,9-10H2,1-3H3,(H2,24,25)/t17-,18+/m0/s1	JECHMSBNYOTNJQ-ZWKOTPCHSA-N	259172	US9499502, 27bl-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259172&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095388	350083870							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336905	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1cccc(c1)-c1nnco1	InChI=1S/C23H20FN5O3S2/c1-22(12-34(30,31)23(2,21(25)28-22)18-8-3-4-9-26-18)19-16(24)11-17(33-19)14-6-5-7-15(10-14)20-29-27-13-32-20/h3-11,13H,12H2,1-2H3,(H2,25,28)/t22-,23-/m0/s1	WAXVMHHDZIPPRK-GOTSBHOMSA-N	259177	US9499502, 27bp-a	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259177&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095120	350083875							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336906	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1cncc(c1)C#N	InChI=1S/C21H18FN5O2S2/c1-20(18-15(22)8-16(30-18)14-7-13(9-23)10-25-11-14)12-31(28,29)21(2,19(24)27-20)17-5-3-4-6-26-17/h3-8,10-11H,12H2,1-2H3,(H2,24,27)/t20-,21-/m0/s1	SLAWTBVXUZMEDY-SFTDATJTSA-N	259179	US9499502, 27bq-a	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259179&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137903	350083877							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336907	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1cncc(c1)C#N	InChI=1S/C21H18FN5O2S2/c1-20(18-15(22)8-16(30-18)14-7-13(9-23)10-25-11-14)12-31(28,29)21(2,19(24)27-20)17-5-3-4-6-26-17/h3-8,10-11H,12H2,1-2H3,(H2,24,27)/t20-,21+/m0/s1	SLAWTBVXUZMEDY-LEWJYISDSA-N	259180	US9499502, 27bq-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259180&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137904	350083878							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336908	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(F)c1)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C23H19F2N3O2S2/c1-22(20-18(25)11-19(31-20)15-6-3-5-14(9-15)12-26)13-32(29,30)23(2,21(27)28-22)16-7-4-8-17(24)10-16/h3-11H,13H2,1-2H3,(H2,27,28)/t22-,23+/m0/s1	PWYWDLXTZZYHQW-XZOQPEGZSA-N	259182	US9499502, 27br-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259182&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137906	350083880							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336909	C[C@]1(CS(=O)(=O)[C@](C)(CC(F)(F)F)C(=N)N1)c1sc(cc1F)-c1cccc(c1)-c1nnco1	InChI=1S/C20H18F4N4O3S2/c1-18(9-33(29,30)19(2,17(25)27-18)8-20(22,23)24)15-13(21)7-14(32-15)11-4-3-5-12(6-11)16-28-26-10-31-16/h3-7,10H,8-9H2,1-2H3,(H2,25,27)/t18-,19+/m0/s1	LJVPBFAZHIFHIY-RBUKOAKNSA-N	259170	US9499502, 27bk-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259170&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095123	350083868							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336910	C[C@]1(CS(=O)(=O)[C@](C)(CC(F)(F)F)C(=N)N1)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C19H17F4N3O2S2/c1-17(10-30(27,28)18(2,16(25)26-17)9-19(21,22)23)15-13(20)7-14(29-15)12-5-3-4-11(6-12)8-24/h3-7H,9-10H2,1-2H3,(H2,25,26)/t17-,18+/m0/s1	XQOLXJKJFXAENW-ZWKOTPCHSA-N	259168	US9499502, 27bj-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259168&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137895	350083866							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336911	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C22H19FN4O2S2/c1-21(19-16(23)11-17(30-19)15-7-5-6-14(10-15)12-24)13-31(28,29)22(2,20(25)27-21)18-8-3-4-9-26-18/h3-11H,13H2,1-2H3,(H2,25,27)/t21-,22+/m0/s1	UPPNJLCAEDNXBS-FCHUYYIVSA-N	259176	US9499502, 27bo-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259176&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137901	350083874							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336912	COc1cncc(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)C(C)(CC(F)(F)F)C(=N)N1	InChI=1S/C18H19F4N3O3S2/c1-16(9-30(26,27)17(2,15(23)25-16)8-18(20,21)22)14-12(19)5-13(29-14)10-4-11(28-3)7-24-6-10/h4-7H,8-9H2,1-3H3,(H2,23,25)/t16-,17?/m0/s1	UDOIOWAQRBOTGU-BHWOMJMDSA-N	259174	US9499502, 27bn-a	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259174&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137899	350083872							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336913	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C22H19FN4O2S2/c1-21(19-16(23)11-17(30-19)15-7-5-6-14(10-15)12-24)13-31(28,29)22(2,20(25)27-21)18-8-3-4-9-26-18/h3-11H,13H2,1-2H3,(H2,25,27)/t21-,22-/m0/s1	UPPNJLCAEDNXBS-VXKWHMMOSA-N	259175	US9499502, 27bo-a	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259175&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137900	350083873							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336914	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccc1F)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C23H19F2N3O2S2/c1-22(20-18(25)11-19(31-20)15-7-5-6-14(10-15)12-26)13-32(29,30)23(2,21(27)28-22)16-8-3-4-9-17(16)24/h3-11H,13H2,1-2H3,(H2,27,28)/t22-,23+/m0/s1	WJAPMRNJIJYRHN-XZOQPEGZSA-N	259184	US9499502, 27bs-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259184&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137908	350083882							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336915	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1cccc(c1)-c1nnco1	InChI=1S/C23H20FN5O3S2/c1-22(12-34(30,31)23(2,21(25)28-22)18-8-3-4-9-26-18)19-16(24)11-17(33-19)14-6-5-7-15(10-14)20-29-27-13-32-20/h3-11,13H,12H2,1-2H3,(H2,25,28)/t22-,23+/m0/s1	WAXVMHHDZIPPRK-XZOQPEGZSA-N	259178	US9499502, 27bp-b	Beta-secretase 2		 1015						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259178&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137902	350083876							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336916	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC2CCOCC2)C(=N)N1			259189	US9499502, 27bx	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259189&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095078	350083887							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336917	COCC1(COC)C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)C#N	InChI=1S/C20H22ClN3O4S2/c1-19(12-30(25,26)20(10-27-2,11-28-3)18(23)24-19)17-15(21)8-16(29-17)14-6-4-5-13(7-14)9-22/h4-8H,10-12H2,1-3H3,(H2,23,24)/t19-/m0/s1	JINCEVSAACSHAP-IBGZPJMESA-N	259185	US9499502, 27bt	Beta-secretase 2		 120						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259185&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137909	350083883							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336918	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C22H25ClN4O3S2/c1-21(19-17(23)8-18(31-19)16-7-15(10-24)11-26-12-16)13-32(28,29)22(2,20(25)27-21)9-14-3-5-30-6-4-14/h7-8,11-12,14H,3-6,9,13H2,1-2H3,(H2,25,27)/t21-,22-/m0/s1	XPFYEGPUXFNIDN-VXKWHMMOSA-N	259188	US9499502, 27bw	Beta-secretase 2		 120						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259188&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137911	350083886							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336919	COCC1(COC)C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cc2cccc(OC)c2[nH]1			259187	US9499502, 27bv	Beta-secretase 2		 120						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259187&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095106	350083885							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336920	COCC1(COC)C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C21H23ClN4O5S2/c1-20(11-33(27,28)21(9-29-2,10-30-3)19(23)25-20)17-15(22)8-16(32-17)13-5-4-6-14(7-13)18-26-24-12-31-18/h4-8,12H,9-11H2,1-3H3,(H2,23,25)/t20-/m0/s1	RBXMYYPSQSUKBI-FQEVSTJZSA-N	259186	US9499502, 27bu	Beta-secretase 2		 120						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259186&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095143	350083884							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336921	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C23H19ClFN5O3S2/c1-22(12-35(31,32)23(2,21(26)28-22)17-5-3-4-10-27-17)18-15(25)11-16(34-18)20-30-29-19(33-20)13-6-8-14(24)9-7-13/h3-11H,12H2,1-2H3,(H2,26,28)/t22-,23+/m0/s1	GGOREHHGRCHOAI-XZOQPEGZSA-N	259193	US9499502, 27bz-b	Beta-secretase 2		 165						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259193&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095138	350083891							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336922	C[C@]1(CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1)c1sc(cc1F)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C20H17ClF4N4O3S2/c1-18(9-34(30,31)19(2,17(26)27-18)8-20(23,24)25)14-12(22)7-13(33-14)16-29-28-15(32-16)10-3-5-11(21)6-4-10/h3-7H,8-9H2,1-2H3,(H2,26,27)/t18-,19-/m0/s1	IBGJBGCEQLLKPR-OALUTQOASA-N	259190	US9499502, 27by-a	Beta-secretase 2		 165						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259190&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137912	350083888							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336923	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1sc(cc1F)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C23H19ClFN5O3S2/c1-22(12-35(31,32)23(2,21(26)28-22)17-5-3-4-10-27-17)18-15(25)11-16(34-18)20-30-29-19(33-20)13-6-8-14(24)9-7-13/h3-11H,12H2,1-2H3,(H2,26,28)/t22-,23-/m0/s1	GGOREHHGRCHOAI-GOTSBHOMSA-N	259192	US9499502, 27bz-a	Beta-secretase 2		 165						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259192&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095389	350083890							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336924	C[C@]1(CS(=O)(=O)[C@](C)(CC(F)(F)F)C(=N)N1)c1sc(cc1F)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C20H17ClF4N4O3S2/c1-18(9-34(30,31)19(2,17(26)27-18)8-20(23,24)25)14-12(22)7-13(33-14)16-29-28-15(32-16)10-3-5-11(21)6-4-10/h3-7H,8-9H2,1-2H3,(H2,26,27)/t18-,19+/m0/s1	IBGJBGCEQLLKPR-RBUKOAKNSA-N	259191	US9499502, 27by-b	Beta-secretase 2		 165						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259191&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095395	350083889							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336925	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cn2ccsc2n1	InChI=1S/C16H17ClN4O2S3/c1-15(2)13(18)20-16(3,8-26(15,22)23)12-9(17)6-11(25-12)10-7-21-4-5-24-14(21)19-10/h4-7H,8H2,1-3H3,(H2,18,20)/t16-/m0/s1	GQVBPTRGNJIZCR-INIZCTEOSA-N	259196	US9499502, 28b	Beta-secretase 2		 62						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259196&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095067	350083894							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336926	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cn2ccccc2n1	InChI=1S/C18H19ClN4O2S2/c1-17(2)16(20)22-18(3,10-27(17,24)25)15-11(19)8-13(26-15)12-9-23-7-5-4-6-14(23)21-12/h4-9H,10H2,1-3H3,(H2,20,22)/t18-/m0/s1	COQYFLFEGKOZTG-SFHVURJKSA-N	259194	US9499502, 28	Beta-secretase 2		 62						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259194&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137918	350083892							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336927	COc1cccn2cc(nc12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H21ClN4O3S2/c1-18(2)17(21)23-19(3,10-29(18,25)26)15-11(20)8-14(28-15)12-9-24-7-5-6-13(27-4)16(24)22-12/h5-9H,10H2,1-4H3,(H2,21,23)/t19-/m0/s1	GPLKYPDGUJLLSO-IBGZPJMESA-N	259195	US9499502, 28a	Beta-secretase 2		 62						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259195&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095108	350083893							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336928	COc1cccc2nc(cn12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H21ClN4O3S2/c1-18(2)17(21)23-19(3,10-29(18,25)26)16-11(20)8-13(28-16)12-9-24-14(22-12)6-5-7-15(24)27-4/h5-9H,10H2,1-4H3,(H2,21,23)/t19-/m0/s1	BZLPSIZFSUZCJU-IBGZPJMESA-N	259197	US9499502, 28c	Beta-secretase 2		 62						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259197&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095070	350083895							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336929	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc2ccc(cc2s1)-c1ccc(F)cc1	InChI=1S/C20H20FN3O2S2/c1-19(2)17(22)24-20(3,11-28(19,25)26)18-23-15-9-6-13(10-16(15)27-18)12-4-7-14(21)8-5-12/h4-10H,11H2,1-3H3,(H2,22,24)/t20-/m0/s1	UMINDAIWBBSGIP-FQEVSTJZSA-N	259200	US9499502, 29b	Beta-secretase 2		 300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259200&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095384	350083898							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336930	COc1cccc(c1)-c1ccc2nc(sc2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C21H23N3O3S2/c1-20(2)18(22)24-21(3,12-29(20,25)26)19-23-16-9-8-14(11-17(16)28-19)13-6-5-7-15(10-13)27-4/h5-11H,12H2,1-4H3,(H2,22,24)/t21-/m0/s1	IIDQWQBYNMDXNY-NRFANRHFSA-N	259202	US9499502, 29d	Beta-secretase 2		 300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259202&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095390	350083900							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336931	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc2ccc(cc2s1)-c1cccc(c1)C#N	InChI=1S/C21H20N4O2S2/c1-20(2)18(23)25-21(3,12-29(20,26)27)19-24-16-8-7-15(10-17(16)28-19)14-6-4-5-13(9-14)11-22/h4-10H,12H2,1-3H3,(H2,23,25)/t21-/m0/s1	IQVDMOASXJVKOQ-NRFANRHFSA-N	259201	US9499502, 29c	Beta-secretase 2		 300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259201&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095386	350083899							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336932	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc2ccc(cc2s1)-c1cccnc1	InChI=1S/C19H20N4O2S2/c1-18(2)16(20)23-19(3,11-27(18,24)25)17-22-14-7-6-12(9-15(14)26-17)13-5-4-8-21-10-13/h4-10H,11H2,1-3H3,(H2,20,23)/t19-/m0/s1	YJLJQDOXXORTJZ-IBGZPJMESA-N	259199	US9499502, 29a	Beta-secretase 2		 300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259199&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562147	350083897							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336933	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc2ccc(cc2s1)-c1ccccc1	InChI=1S/C20H21N3O2S2/c1-19(2)17(21)23-20(3,12-27(19,24)25)18-22-15-10-9-14(11-16(15)26-18)13-7-5-4-6-8-13/h4-11H,12H2,1-3H3,(H2,21,23)/t20-/m0/s1	UHNURAQNNNHQGD-FQEVSTJZSA-N	259198	US9499502, 29	Beta-secretase 2		 300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259198&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095139	350083896							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336934	COc1cccc(c1)[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(F)ccc1F	InChI=1S/C19H20F2N2O3S/c1-18(15-10-13(20)7-8-16(15)21)11-27(24,25)19(2,17(22)23-18)12-5-4-6-14(9-12)26-3/h4-10H,11H2,1-3H3,(H2,22,23)/t18-,19-/m0/s1	BKKOAHSHQKUJQE-OALUTQOASA-N	259214	US9499502, 32e-a	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259214&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095293	350083912							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336935	COC[C@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(F)ccc1F	InChI=1S/C14H18F2N2O3S/c1-13(10-6-9(15)4-5-11(10)16)8-22(19,20)14(2,7-21-3)12(17)18-13/h4-6H,7-8H2,1-3H3,(H2,17,18)/t13-,14+/m0/s1	NSBQDVJYIQYEEC-UONOGXRCSA-N	259212	US9499502, 32d-a	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259212&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953982	350083910							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336936	Cc1nc2cc(C[C@]3(C)C(=N)N[C@@](C)(CS3(=O)=O)c3cc(F)ccc3F)ccc2o1	InChI=1S/C21H21F2N3O3S/c1-12-25-17-8-13(4-7-18(17)29-12)10-21(3)19(24)26-20(2,11-30(21,27)28)15-9-14(22)5-6-16(15)23/h4-9H,10-11H2,1-3H3,(H2,24,26)/t20-,21+/m0/s1	ZAAADZOILKRDRH-LEWJYISDSA-N	259208	US9499502, 32a-a	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259208&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953978	350083906							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336937	Cc1nc2ccc(C[C@@]3(C)C(=N)N[C@@](C)(CS3(=O)=O)c3cc(F)ccc3F)cc2o1	InChI=1S/C21H21F2N3O3S/c1-12-25-17-7-4-13(8-18(17)29-12)10-21(3)19(24)26-20(2,11-30(21,27)28)15-9-14(22)5-6-16(15)23/h4-9H,10-11H2,1-3H3,(H2,24,26)/t20-,21-/m0/s1	DDOOFZOHDKEBLM-SFTDATJTSA-N	259211	US9499502, 32c-b	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259211&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953981	350083909							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336938	Cc1nc2ccc(C[C@]3(C)C(=N)N[C@@](C)(CS3(=O)=O)c3cc(F)ccc3F)cc2o1	InChI=1S/C21H21F2N3O3S/c1-12-25-17-7-4-13(8-18(17)29-12)10-21(3)19(24)26-20(2,11-30(21,27)28)15-9-14(22)5-6-16(15)23/h4-9H,10-11H2,1-3H3,(H2,24,26)/t20-,21+/m0/s1	DDOOFZOHDKEBLM-LEWJYISDSA-N	259210	US9499502, 32c-a	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259210&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953980	350083908							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336939	COC[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(F)ccc1F	InChI=1S/C14H18F2N2O3S/c1-13(10-6-9(15)4-5-11(10)16)8-22(19,20)14(2,7-21-3)12(17)18-13/h4-6H,7-8H2,1-3H3,(H2,17,18)/t13-,14-/m0/s1	NSBQDVJYIQYEEC-KBPBESRZSA-N	259213	US9499502, 32d-b	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259213&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953983	350083911							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336940	Cc1nc2cc(C[C@@]3(C)C(=N)N[C@@](C)(CS3(=O)=O)c3cc(F)ccc3F)ccc2o1	InChI=1S/C21H21F2N3O3S/c1-12-25-17-8-13(4-7-18(17)29-12)10-21(3)19(24)26-20(2,11-30(21,27)28)15-9-14(22)5-6-16(15)23/h4-9H,10-11H2,1-3H3,(H2,24,26)/t20-,21-/m0/s1	ZAAADZOILKRDRH-SFTDATJTSA-N	259209	US9499502, 32a-b	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259209&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953979	350083907							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336941	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(Br)c1)c1ccc(F)cc1F	InChI=1S/C18H17BrF2N2O2S/c1-17(14-7-6-13(20)9-15(14)21)10-26(24,25)18(2,16(22)23-17)11-4-3-5-12(19)8-11/h3-9H,10H2,1-2H3,(H2,22,23)/t17-,18+/m0/s1	XTRISXZRTBIAPI-ZWKOTPCHSA-N	259217	US9499502, 32g-b	Beta-secretase 2		 2300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259217&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095407	350083915							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336942	C[C@]1(CS(=O)(=O)[C@@](C)(Cc2cccc(Br)c2)C(=N)N1)c1ccc(F)cc1F	InChI=1S/C19H19BrF2N2O2S/c1-18(15-7-6-14(21)9-16(15)22)11-27(25,26)19(2,17(23)24-18)10-12-4-3-5-13(20)8-12/h3-9H,10-11H2,1-2H3,(H2,23,24)/t18-,19-/m0/s1	TURMKSIUAKKACD-OALUTQOASA-N	259222	US9499502, 32j-a	Beta-secretase 2		 2300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259222&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095409	350083920							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336943	COc1cccc(C[C@@]2(C)C(=N)N[C@@](C)(CS2(=O)=O)c2ccc(F)cc2F)c1	InChI=1S/C20H22F2N2O3S/c1-19(16-8-7-14(21)10-17(16)22)12-28(25,26)20(2,18(23)24-19)11-13-5-4-6-15(9-13)27-3/h4-10H,11-12H2,1-3H3,(H2,23,24)/t19-,20-/m0/s1	VXLIZMUJIVXLCH-PMACEKPBSA-N	259220	US9499502, 32i-a	Beta-secretase 2		 2300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095403	350083918							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336944	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1F	InChI=1S/C19H17F5N2O2S/c1-17(14-7-6-13(20)9-15(14)21)10-29(27,28)18(2,16(25)26-17)11-4-3-5-12(8-11)19(22,23)24/h3-9H,10H2,1-2H3,(H2,25,26)/t17-,18+/m0/s1	DPSKZHWZWPCSEG-ZWKOTPCHSA-N	259219	US9499502, 32h-b	Beta-secretase 2		 2300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259219&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095408	350083917							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336945	COc1cccc(C[C@]2(C)C(=N)N[C@@](C)(CS2(=O)=O)c2ccc(F)cc2F)c1	InChI=1S/C20H22F2N2O3S/c1-19(16-8-7-14(21)10-17(16)22)12-28(25,26)20(2,18(23)24-19)11-13-5-4-6-15(9-13)27-3/h4-10H,11-12H2,1-3H3,(H2,23,24)/t19-,20+/m0/s1	VXLIZMUJIVXLCH-VQTJNVASSA-N	259221	US9499502, 32i-b	Beta-secretase 2		 2300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095406	350083919							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336946	COc1cccc(c1)[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1ccc(F)cc1F	InChI=1S/C19H20F2N2O3S/c1-18(15-8-7-13(20)10-16(15)21)11-27(24,25)19(2,17(22)23-18)12-5-4-6-14(9-12)26-3/h4-10H,11H2,1-3H3,(H2,22,23)/t18-,19-/m0/s1	AHHKLVYNRVYBAW-OALUTQOASA-N	259215	US9499502, 32f-a	Beta-secretase 2		 2300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259215&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095401	350083913							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336947	C[C@]1(CS(=O)(=O)[C@](C)(Cc2cccc(Br)c2)C(=N)N1)c1ccc(F)cc1F	InChI=1S/C19H19BrF2N2O2S/c1-18(15-7-6-14(21)9-16(15)22)11-27(25,26)19(2,17(23)24-18)10-12-4-3-5-13(20)8-12/h3-9H,10-11H2,1-2H3,(H2,23,24)/t18-,19+/m0/s1	TURMKSIUAKKACD-RBUKOAKNSA-N	259223	US9499502, 32j-b	Beta-secretase 2		 2300						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095404	350083921							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336948	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(OCC2CC2)c1)c1ccc(F)cc1F	InChI=1S/C22H24F2N2O3S/c1-21(18-9-8-16(23)11-19(18)24)13-30(27,28)22(2,20(25)26-21)15-4-3-5-17(10-15)29-12-14-6-7-14/h3-5,8-11,14H,6-7,12-13H2,1-2H3,(H2,25,26)/t21-,22-/m0/s1	DHTIUSNCUKMODP-VXKWHMMOSA-N	259227	US9499502, 34b	Beta-secretase 2		 475						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095086	350083925							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336949	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccc1)c1ccc(F)cc1F	InChI=1S/C18H18F2N2O2S/c1-17(14-9-8-13(19)10-15(14)20)11-25(23,24)18(2,16(21)22-17)12-6-4-3-5-7-12/h3-10H,11H2,1-2H3,(H2,21,22)/t17-,18-/m0/s1	ZGFPPTZGHLBQOT-ROUUACIJSA-N	259224	US9499502, 33	Beta-secretase 2		 475						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259224&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095299	350083922							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336950	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(O)c1)c1ccc(F)cc1F	InChI=1S/C18H18F2N2O3S/c1-17(14-7-6-12(19)9-15(14)20)10-26(24,25)18(2,16(21)22-17)11-4-3-5-13(23)8-11/h3-9,23H,10H2,1-2H3,(H2,21,22)/t17-,18-/m0/s1	RVJKKCVSYCAWNF-ROUUACIJSA-N	259225	US9499502, 34	Beta-secretase 2		 475						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259225&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095301	350083923							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336951	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(OCc2ccccc2)c1)c1ccc(F)cc1F	InChI=1S/C25H24F2N2O3S/c1-24(21-12-11-19(26)14-22(21)27)16-33(30,31)25(2,23(28)29-24)18-9-6-10-20(13-18)32-15-17-7-4-3-5-8-17/h3-14H,15-16H2,1-2H3,(H2,28,29)/t24-,25-/m0/s1	KLDBQCFQDXEHEF-DQEYMECFSA-N	259226	US9499502, 34a	Beta-secretase 2		 475						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259226&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095300	350083924							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336952	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(OCc2ccccc2)c1)c1cc(F)ccc1F	InChI=1S/C25H24F2N2O3S/c1-24(21-14-19(26)11-12-22(21)27)16-33(30,31)25(2,23(28)29-24)18-9-6-10-20(13-18)32-15-17-7-4-3-5-8-17/h3-14H,15-16H2,1-2H3,(H2,28,29)/t24-,25-/m0/s1	OMUXJZGOABZJLW-DQEYMECFSA-N	259229	US9499502, 34d-a	Beta-secretase 2		 4150						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094931	350083927							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336953	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(O)c1)c1cc(F)ccc1F	InChI=1S/C18H18F2N2O3S/c1-17(14-9-12(19)6-7-15(14)20)10-26(24,25)18(2,16(21)22-17)11-4-3-5-13(23)8-11/h3-9,23H,10H2,1-2H3,(H2,21,22)/t17-,18-/m0/s1	MVVIVKRZELZVGT-ROUUACIJSA-N	259228	US9499502, 34c-a	Beta-secretase 2		 4150						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095083	350083926							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336954	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N)ccc1F	InChI=1S/C13H18FN3O2S/c1-12(2)11(16)17-13(3,7-20(12,18)19)9-6-8(15)4-5-10(9)14/h4-6H,7,15H2,1-3H3,(H2,16,17)/t13-/m0/s1	HIUMBVBKCIHWGI-ZDUSSCGKSA-N	259233	US9499502, Table A: Entry 2	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259233&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86715778	350083931							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336955	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C16H22FN3O2S/c1-15(12-7-11(18)5-6-13(12)17)9-23(21,22)16(2,14(19)20-15)8-10-3-4-10/h5-7,10H,3-4,8-9,18H2,1-2H3,(H2,19,20)/t15-,16-/m0/s1	MGOIGGZKEINOPW-HOTGVXAUSA-N	259244	US9499502, Table A: Entry 47	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259244&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095196	350083942							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336956	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N)cc(Cl)c1F	InChI=1S/C13H17ClFN3O2S/c1-12(2)11(17)18-13(3,6-21(12,19)20)8-4-7(16)5-9(14)10(8)15/h4-5H,6,16H2,1-3H3,(H2,17,18)/t13-/m0/s1	VQVWJAIQYZNJTD-ZDUSSCGKSA-N	259235	US9499502, Table A: Entry 9	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095186	350083933							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336957	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cccc(Cl)c1F	InChI=1S/C13H16ClFN2O2S/c1-12(2)11(16)17-13(3,7-20(12,18)19)8-5-4-6-9(14)10(8)15/h4-6H,7H2,1-3H3,(H2,16,17)/t13-/m0/s1	VKIIBQCWYXDREJ-ZDUSSCGKSA-N	259234	US9499502, Table A: Entry 7	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259234&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095184	350083932							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336958	C[C@]1(CS(=O)(=O)[C@@](C)(C2CCOCC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C17H24FN3O3S/c1-16(13-9-12(19)3-4-14(13)18)10-25(22,23)17(2,15(20)21-16)11-5-7-24-8-6-11/h3-4,9,11H,5-8,10,19H2,1-2H3,(H2,20,21)/t16-,17-/m0/s1	ZIZKAYFYVRHAAE-IRXDYDNUSA-N	259245	US9499502, Table A: Entry 50	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259245&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095194	350083943							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336959	CC(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C15H20FN3O3S/c1-9(20)18-10-5-6-12(16)11(7-10)15(4)8-23(21,22)14(2,3)13(17)19-15/h5-7H,8H2,1-4H3,(H2,17,19)(H,18,20)/t15-/m0/s1	QJGMHDHBHISMMB-HNNXBMFYSA-N	258939	US9499502, 9an	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258939&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562865	350083641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336960	C[C@]1(CS(=O)(=O)[C@@](C)(CC2CCOCC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C18H26FN3O3S/c1-17(14-9-13(20)3-4-15(14)19)11-26(23,24)18(2,16(21)22-17)10-12-5-7-25-8-6-12/h3-4,9,12H,5-8,10-11,20H2,1-2H3,(H2,21,22)/t17-,18-/m0/s1	FQSWXNKSCZCYBW-ROUUACIJSA-N	259246	US9499502, Table A: Entry 53	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095198	350083944							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336961	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1)c1cc(N)ccc1F	InChI=1S/C18H19F2N3O2S/c1-17(14-9-13(21)6-7-15(14)20)10-26(24,25)18(2,16(22)23-17)11-4-3-5-12(19)8-11/h3-9H,10,21H2,1-2H3,(H2,22,23)/t17-,18-/m0/s1	RLLHTXUBBDTSAX-ROUUACIJSA-N	259247	US9499502, Table A: Entry 60	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095147	350083945							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336962	CC(C)[C@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N)ccc1F	InChI=1S/C15H22FN3O2S/c1-9(2)15(4)13(18)19-14(3,8-22(15,20)21)11-7-10(17)5-6-12(11)16/h5-7,9H,8,17H2,1-4H3,(H2,18,19)/t14-,15+/m0/s1	ASLNFVWKKHRNQF-LSDHHAIUSA-N	259241	US9499502, Table A: Entry 28	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095212	350083939							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336963	CC(C)[C@@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N)ccc1F	InChI=1S/C15H22FN3O2S/c1-9(2)15(4)13(18)19-14(3,8-22(15,20)21)11-7-10(17)5-6-12(11)16/h5-7,9H,8,17H2,1-4H3,(H2,18,19)/t14-,15-/m0/s1	ASLNFVWKKHRNQF-GJZGRUSLSA-N	259240	US9499502, Table A: Entry 27	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259240&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095214	350083938							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336964	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cncnc1	InChI=1S/C15H17ClN4O2S2/c1-14(2)13(17)20-15(3,7-24(14,21)22)12-10(16)4-11(23-12)9-5-18-8-19-6-9/h4-6,8H,7H2,1-3H3,(H2,17,20)/t15-/m0/s1	KZLVTQQRYCUCJW-HNNXBMFYSA-N	259103	US9499502, 24	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259103&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137857	350083803							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336965	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1nc(N)ccc1F	InChI=1S/C12H17FN4O2S/c1-11(2)10(15)17-12(3,6-20(11,18)19)9-7(13)4-5-8(14)16-9/h4-5H,6H2,1-3H3,(H2,14,16)(H2,15,17)/t12-/m0/s1	DCJNEELRLJWWNF-LBPRGKRZSA-N	259239	US9499502, Table A: Entry 20	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259239&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095532	350083937							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336966	C[C@]1(CS(=O)(=O)[C@@](C)(C2CCC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C16H22FN3O2S/c1-15(12-8-11(18)6-7-13(12)17)9-23(21,22)16(2,14(19)20-15)10-4-3-5-10/h6-8,10H,3-5,9,18H2,1-2H3,(H2,19,20)/t15-,16-/m0/s1	UTUTUBQKAQZPDF-HOTGVXAUSA-N	259243	US9499502, Table A: Entry 39	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259243&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095224	350083941							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336967	C[C@]1(CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C14H17F4N3O2S/c1-12(9-5-8(19)3-4-10(9)15)7-24(22,23)13(2,11(20)21-12)6-14(16,17)18/h3-5H,6-7,19H2,1-2H3,(H2,20,21)/t12-,13-/m0/s1	AEVCDHUWLDCDCO-STQMWFEESA-N	259242	US9499502, Table A: Entry 35	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259242&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095222	350083940							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336968	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)cccc1F	InChI=1S/C13H16F2N2O2S/c1-12(2)11(16)17-13(3,7-20(12,18)19)10-8(14)5-4-6-9(10)15/h4-6H,7H2,1-3H3,(H2,16,17)/t13-/m0/s1	UHMFOHSPVDPZQU-ZDUSSCGKSA-N	259236	US9499502, Table A: Entry 11	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259236&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095185	350083934							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336969	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(N)c1F	InChI=1S/C13H17F2N3O2S/c1-12(2)11(17)18-13(3,6-21(12,19)20)9-7(14)4-5-8(16)10(9)15/h4-5H,6,16H2,1-3H3,(H2,17,18)/t13-/m0/s1	IRNQRCFJTGZSBQ-ZDUSSCGKSA-N	259237	US9499502, Table A: Entry 13	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095188	350083935							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336970	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(F)c1F	InChI=1S/C13H15F3N2O2S/c1-12(2)11(17)18-13(3,6-21(12,19)20)9-7(14)4-5-8(15)10(9)16/h4-5H,6H2,1-3H3,(H2,17,18)/t13-/m0/s1	RIRNSBITCCISLU-ZDUSSCGKSA-N	259238	US9499502, Table A: Entry 14	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259238&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095533	350083936							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336971	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2cnc(OCC3CC3)cn2)ccc1F	InChI=1S/C22H26FN5O4S/c1-21(2)20(24)28-22(3,12-33(21,30)31)15-8-14(6-7-16(15)23)27-19(29)17-9-26-18(10-25-17)32-11-13-4-5-13/h6-10,13H,4-5,11-12H2,1-3H3,(H2,24,28)(H,27,29)/t22-/m0/s1	QXXILWIQQCMRJP-QFIPXVFZSA-N	258910	US9499502, 9p	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258910&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562764	350083612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336972	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(Br)c1)c1ccc(F)cc1F	InChI=1S/C18H17BrF2N2O2S/c1-17(14-7-6-13(20)9-15(14)21)10-26(24,25)18(2,16(22)23-17)11-4-3-5-12(19)8-11/h3-9H,10H2,1-2H3,(H2,22,23)/t17-,18-/m0/s1	XTRISXZRTBIAPI-ROUUACIJSA-N	259216	US9499502, 32g-a	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259216&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095400	350083914							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336973	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1sc(Br)cc1F	InChI=1S/C15H15BrFN3O2S2/c1-14(12-9(17)7-11(16)23-12)8-24(21,22)15(2,13(18)20-14)10-5-3-4-6-19-10/h3-7H,8H2,1-2H3,(H2,18,20)/t14-,15-/m0/s1	QGJRGRFFMPLSTL-GJZGRUSLSA-N	259255	US9499502, Table A: Entry 85	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259255&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562260	350083952							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336974	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1)c1sc(Br)cc1F	InChI=1S/C16H15BrF2N2O2S2/c1-15(13-11(19)7-12(17)24-13)8-25(22,23)16(2,14(20)21-15)9-4-3-5-10(18)6-9/h3-7H,8H2,1-2H3,(H2,20,21)/t15-,16-/m0/s1	KAQDPBVBAANXAP-HOTGVXAUSA-N	259256	US9499502, Table A: Entry 87	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095244	350083953							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336428	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H20F2N4O3S/c1-18(2)17(22)25-19(3,10-29(18,27)28)13-8-12(5-6-14(13)21)24-16(26)15-7-4-11(20)9-23-15/h4-9H,10H2,1-3H3,(H2,22,25)(H,24,26)/t19-/m0/s1	IXNHXYGWJABLFS-IBGZPJMESA-N	258891	US9499502, 1	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258891&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562572	350083593							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336429	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ncc(F)cc2F)ccc1F	InChI=1S/C19H19F3N4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)12-7-11(4-5-13(12)21)25-16(27)15-14(22)6-10(20)8-24-15/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	FHMBZKIOXUIBRB-IBGZPJMESA-N	258892	US9499502, 2	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258892&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562667	350083594							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336430	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H22FN5O4S/c1-18(2)17(21)25-19(3,10-30(18,27)28)12-7-11(5-6-13(12)20)24-16(26)14-8-23-15(29-4)9-22-14/h5-9H,10H2,1-4H3,(H2,21,25)(H,24,26)/t19-/m0/s1	HVMRBCNORJDLCW-IBGZPJMESA-N	258893	US9499502, 3	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258893&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562573	350083595							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336431	Cc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H23FN4O3S/c1-12-5-8-16(23-10-12)17(26)24-13-6-7-15(21)14(9-13)20(4)11-29(27,28)19(2,3)18(22)25-20/h5-10H,11H2,1-4H3,(H2,22,25)(H,24,26)/t20-/m0/s1	OYKYKQDWTVOZPY-FQEVSTJZSA-N	258894	US9499502, 4	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258894&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562668	350083596							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336432	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H20ClFN4O3S/c1-18(2)17(22)25-19(3,10-29(18,27)28)13-8-12(5-6-14(13)21)24-16(26)15-7-4-11(20)9-23-15/h4-9H,10H2,1-3H3,(H2,22,25)(H,24,26)/t19-/m0/s1	LMHDJRUKZXENER-IBGZPJMESA-N	258895	US9499502, 5	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258895&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562362	350083597							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336433	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C20H20F4N4O3S/c1-18(2)17(25)28-19(3,10-32(18,30)31)13-8-12(5-6-14(13)21)27-16(29)15-7-4-11(9-26-15)20(22,23)24/h4-9H,10H2,1-3H3,(H2,25,28)(H,27,29)/t19-/m0/s1	SCNPRYSPQJETHY-IBGZPJMESA-N	258896	US9499502, 6	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258896&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562666	350083598							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336434	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F	InChI=1S/C19H19ClF2N4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)12-7-11(4-5-13(12)21)25-16(27)15-14(22)6-10(20)8-24-15/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	QDKKAFVEGFXSCW-IBGZPJMESA-N	258897	US9499502, 7	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258897&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562571	350083599							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336435	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cc2)ccc1F	InChI=1S/C20H21ClFN3O3S/c1-19(2)18(23)25-20(3,11-29(19,27)28)15-10-14(8-9-16(15)22)24-17(26)12-4-6-13(21)7-5-12/h4-10H,11H2,1-3H3,(H2,23,25)(H,24,26)/t20-/m0/s1	NTOUGJLSZMJNRG-FQEVSTJZSA-N	258898	US9499502, 8	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258898&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562669	350083600							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336436	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C19H19Cl2FN4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)12-7-11(4-5-14(12)22)25-16(27)15-13(21)6-10(20)8-24-15/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	FFOPNBRCPXGXIQ-IBGZPJMESA-N	258899	US9499502, 9	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258899&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66553193	350083601							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336437	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H23FN4O4S/c1-19(2)18(22)25-20(3,11-30(19,27)28)14-9-12(5-7-15(14)21)24-17(26)16-8-6-13(29-4)10-23-16/h5-10H,11H2,1-4H3,(H2,22,25)(H,24,26)/t20-/m0/s1	XUTZNLTZWSGTCL-FQEVSTJZSA-N	258900	US9499502, 9a	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258900&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73669986	350083602							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336438	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H20FN5O3S/c1-19(2)18(23)26-20(3,11-30(19,28)29)14-8-13(5-6-15(14)21)25-17(27)16-7-4-12(9-22)10-24-16/h4-8,10H,11H2,1-3H3,(H2,23,26)(H,25,27)/t20-/m0/s1	SQPMMXMVMZGIEG-FQEVSTJZSA-N	258901	US9499502, 9b	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258901&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562670	350083603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336439	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C20H21F3N4O4S/c1-19(2)17(24)27-20(3,10-32(19,29)30)13-8-11(4-6-14(13)21)26-16(28)15-7-5-12(9-25-15)31-18(22)23/h4-9,18H,10H2,1-3H3,(H2,24,27)(H,26,28)/t20-/m0/s1	FVPJKQJIMFPNPL-FQEVSTJZSA-N	258902	US9499502, 9c	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258902&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562363	350083604							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336440	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)c(F)c1	InChI=1S/C20H22F2N4O4S/c1-19(2)18(23)26-20(3,10-31(19,28)29)13-7-11(5-6-14(13)21)25-17(27)16-15(22)8-12(30-4)9-24-16/h5-9H,10H2,1-4H3,(H2,23,26)(H,25,27)/t20-/m0/s1	QDDMYLHCJOACSD-FQEVSTJZSA-N	258903	US9499502, 9d	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258903&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138934	350083605							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336441	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2cnc(cn2)C(F)(F)F)ccc1F	InChI=1S/C19H19F4N5O3S/c1-17(2)16(24)28-18(3,9-32(17,30)31)11-6-10(4-5-12(11)20)27-15(29)13-7-26-14(8-25-13)19(21,22)23/h4-8H,9H2,1-3H3,(H2,24,28)(H,27,29)/t18-/m0/s1	YWTKWRVWZMDOMN-SFHVURJKSA-N	258904	US9499502, 9e	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258904&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562364	350083606							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336442	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cc2F)ccc1F	InChI=1S/C20H20F3N3O3S/c1-19(2)18(24)26-20(3,10-30(19,28)29)14-9-12(5-7-15(14)22)25-17(27)13-6-4-11(21)8-16(13)23/h4-9H,10H2,1-3H3,(H2,24,26)(H,25,27)/t20-/m0/s1	SKJAYJDIZAUBDV-FQEVSTJZSA-N	258905	US9499502, 9f	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258905&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094861	350083607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336443	Cc1nc(no1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C17H20FN5O4S/c1-9-20-13(23-27-9)14(24)21-10-5-6-12(18)11(7-10)17(4)8-28(25,26)16(2,3)15(19)22-17/h5-7H,8H2,1-4H3,(H2,19,22)(H,21,24)/t17-/m0/s1	TZSUMHQMHPAQBL-KRWDZBQOSA-N	258906	US9499502, 9g	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258906&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562671	350083608							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336444	Cc1noc(n1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C17H20FN5O4S/c1-9-20-14(27-23-9)13(24)21-10-5-6-12(18)11(7-10)17(4)8-28(25,26)16(2,3)15(19)22-17/h5-7H,8H2,1-4H3,(H2,19,22)(H,21,24)/t17-/m0/s1	NTTQOIKGXAMGEV-KRWDZBQOSA-N	258907	US9499502, 9h	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258907&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094862	350083609							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336445	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F	InChI=1S/C19H20F3N5O3S/c1-18(2)17(23)27-19(3,9-31(18,29)30)11-6-10(4-5-12(11)20)26-16(28)14-8-24-13(7-25-14)15(21)22/h4-8,15H,9H2,1-3H3,(H2,23,27)(H,26,28)/t19-/m0/s1	PRODEHRJOZCZNV-IBGZPJMESA-N	258911	US9499502, 9q	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258911&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72548197	350083613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336446	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)cc(F)c1F	InChI=1S/C19H19F3N4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)12-6-11(7-13(21)15(12)22)25-16(27)14-5-4-10(20)8-24-14/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	KEGHVSLECPSGMJ-IBGZPJMESA-N	258912	US9499502, 9k	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258912&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562365	350083614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336447	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C19H19ClF2N4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)12-6-11(7-13(21)15(12)22)25-16(27)14-5-4-10(20)8-24-14/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	VDJQZEYADVRHBV-IBGZPJMESA-N	258913	US9499502, 9l	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258913&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562366	350083615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336448	COc1ccc(nc1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H22F2N4O4S/c1-19(2)18(23)26-20(3,10-31(19,28)29)13-7-11(8-14(21)16(13)22)25-17(27)15-6-5-12(30-4)9-24-15/h5-9H,10H2,1-4H3,(H2,23,26)(H,25,27)/t20-/m0/s1	OXAQWIUJJGPTSG-FQEVSTJZSA-N	258914	US9499502, 9m	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258914&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562765	350083616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336449	COc1cnc(C(=O)Nc2cc(F)c(F)c(c2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)c(F)c1	InChI=1S/C20H21F3N4O4S/c1-19(2)18(24)27-20(3,9-32(19,29)30)12-5-10(6-13(21)15(12)23)26-17(28)16-14(22)7-11(31-4)8-25-16/h5-8H,9H2,1-4H3,(H2,24,27)(H,26,28)/t20-/m0/s1	NYBUFMMBZQXQOA-FQEVSTJZSA-N	258916	US9499502, 9o	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258916&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094865	350083618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336450	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2cnc(cn2)C(F)F)cc(F)c1F	InChI=1S/C19H19F4N5O3S/c1-18(2)17(24)28-19(3,8-32(18,30)31)10-4-9(5-11(20)14(10)21)27-16(29)13-7-25-12(6-26-13)15(22)23/h4-7,15H,8H2,1-3H3,(H2,24,28)(H,27,29)/t19-/m0/s1	WSTATZKBJIAWLZ-IBGZPJMESA-N	258917	US9499502, 9r	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258917&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562766	350083619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336451	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)cc(Cl)c1F	InChI=1S/C19H19ClF2N4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)12-6-11(7-13(20)15(12)22)25-16(27)14-5-4-10(21)8-24-14/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	QVROUMCNQYYKQF-IBGZPJMESA-N	258918	US9499502, 9s	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258918&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095030	350083620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336452	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)cc(Cl)c1F	InChI=1S/C19H19Cl2FN4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)12-6-11(7-13(21)15(12)22)25-16(27)14-5-4-10(20)8-24-14/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	JYPCIVPGVFTWFK-IBGZPJMESA-N	258919	US9499502, 9t	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258919&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562767	350083621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336453	COc1ccc(nc1)C(=O)Nc1cc(Cl)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H22ClFN4O4S/c1-19(2)18(23)26-20(3,10-31(19,28)29)13-7-11(8-14(21)16(13)22)25-17(27)15-6-5-12(30-4)9-24-15/h5-9H,10H2,1-4H3,(H2,23,26)(H,25,27)/t20-/m0/s1	GJEHYZOSGZEFFS-FQEVSTJZSA-N	258920	US9499502, 9u	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258920&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095028	350083622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336454	COc1cnc(cn1)C(=O)Nc1cc(Cl)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H21ClFN5O4S/c1-18(2)17(22)26-19(3,9-31(18,28)29)11-5-10(6-12(20)15(11)21)25-16(27)13-7-24-14(30-4)8-23-13/h5-8H,9H2,1-4H3,(H2,22,26)(H,25,27)/t19-/m0/s1	DNGJVURDCCXRQD-IBGZPJMESA-N	258922	US9499502, 9w	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258922&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095032	350083624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336455	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1c(F)ccc(NC(=O)c2ccc(F)cn2)c1F	InChI=1S/C19H19F3N4O3S/c1-18(2)17(23)26-19(3,9-30(18,28)29)14-11(21)5-7-12(15(14)22)25-16(27)13-6-4-10(20)8-24-13/h4-8H,9H2,1-3H3,(H2,23,26)(H,25,27)/t19-/m0/s1	GMSQNHWKNHFWBT-IBGZPJMESA-N	258923	US9499502, 9x	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258923&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094871	350083625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336456	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1c(F)c(F)cc(NC(=O)c2ccc(F)cn2)c1F	InChI=1S/C19H18F4N4O3S/c1-18(2)17(24)27-19(3,8-31(18,29)30)13-14(22)10(21)6-12(15(13)23)26-16(28)11-5-4-9(20)7-25-11/h4-7H,8H2,1-3H3,(H2,24,27)(H,26,28)/t19-/m0/s1	ARJRJSVTBILVQH-IBGZPJMESA-N	258926	US9499502, 9aa	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258926&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094869	350083628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336457	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)c(F)cc(NC(=O)c2ccc(Cl)cn2)c1F	InChI=1S/C19H18ClF3N4O3S/c1-18(2)17(24)27-19(3,8-31(18,29)30)13-14(22)10(21)6-12(15(13)23)26-16(28)11-5-4-9(20)7-25-11/h4-7H,8H2,1-3H3,(H2,24,27)(H,26,28)/t19-/m0/s1	RXEPCKJQYHTXHQ-IBGZPJMESA-N	258927	US9499502, 9ab	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258927&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095220	350083629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336458	CC1(COC1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H24FN3O4S/c1-16(2)14(20)22-18(4,10-27(16,24)25)12-7-11(5-6-13(12)19)21-15(23)17(3)8-26-9-17/h5-7H,8-10H2,1-4H3,(H2,20,22)(H,21,23)/t18-/m0/s1	VEXWTINZVXKXBZ-SFHVURJKSA-N	258931	US9499502, 9af	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258931&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562861	350083633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336459	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)CC(F)(F)F)ccc1F	InChI=1S/C16H19F4N3O3S/c1-14(2)13(21)23-15(3,8-27(14,25)26)10-6-9(4-5-11(10)17)22-12(24)7-16(18,19)20/h4-6H,7-8H2,1-3H3,(H2,21,23)(H,22,24)/t15-/m0/s1	VQHARPRCUQTSRZ-HNNXBMFYSA-N	258932	US9499502, 9ag	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258932&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095159	350083634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336460	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)C2(CC2)C#N)ccc1F	InChI=1S/C18H21FN4O3S/c1-16(2)14(21)23-17(3,10-27(16,25)26)12-8-11(4-5-13(12)19)22-15(24)18(9-20)6-7-18/h4-5,8H,6-7,10H2,1-3H3,(H2,21,23)(H,22,24)/t17-/m0/s1	NZQFHOHJTWFFRR-KRWDZBQOSA-N	258933	US9499502, 9ah	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258933&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562862	350083635							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336461	CC1(CC1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H24FN3O3S/c1-16(2)14(20)22-18(4,10-26(16,24)25)12-9-11(5-6-13(12)19)21-15(23)17(3)7-8-17/h5-6,9H,7-8,10H2,1-4H3,(H2,20,22)(H,21,23)/t18-/m0/s1	JSHPIUJXGLKASD-SFHVURJKSA-N	258935	US9499502, 9aj	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258935&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094882	350083637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336462	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)C2CC2)ccc1F	InChI=1S/C17H22FN3O3S/c1-16(2)15(19)21-17(3,9-25(16,23)24)12-8-11(6-7-13(12)18)20-14(22)10-4-5-10/h6-8,10H,4-5,9H2,1-3H3,(H2,19,21)(H,20,22)/t17-/m0/s1	SOZURKJWQHRDGZ-KRWDZBQOSA-N	258938	US9499502, 9am	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258938&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094885	350083640							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336463	Cc1noc(CC(=O)Nc2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)n1	InChI=1S/C18H22FN5O4S/c1-10-21-15(28-24-10)8-14(25)22-11-5-6-13(19)12(7-11)18(4)9-29(26,27)17(2,3)16(20)23-18/h5-7H,8-9H2,1-4H3,(H2,20,23)(H,22,25)/t18-/m0/s1	TVBJHMYSHOTHOU-SFHVURJKSA-N	258940	US9499502, 9ao	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258940&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094949	350083642							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336464	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)C2CCC2)ccc1F	InChI=1S/C18H24FN3O3S/c1-17(2)16(20)22-18(3,10-26(17,24)25)13-9-12(7-8-14(13)19)21-15(23)11-5-4-6-11/h7-9,11H,4-6,10H2,1-3H3,(H2,20,22)(H,21,23)/t18-/m0/s1	IJTSJTZGLJYTQI-SFHVURJKSA-N	258942	US9499502, 9aq	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258942&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562866	350083644							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336465	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)CC2CC2)ccc1F	InChI=1S/C18H24FN3O3S/c1-17(2)16(20)22-18(3,10-26(17,24)25)13-9-12(6-7-14(13)19)21-15(23)8-11-4-5-11/h6-7,9,11H,4-5,8,10H2,1-3H3,(H2,20,22)(H,21,23)/t18-/m0/s1	QQPUUBKKAPJRCL-SFHVURJKSA-N	258943	US9499502, 9ar	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258943&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094879	350083645							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336466	CCC(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H22FN3O3S/c1-5-13(21)19-10-6-7-12(17)11(8-10)16(4)9-24(22,23)15(2,3)14(18)20-16/h6-8H,5,9H2,1-4H3,(H2,18,20)(H,19,21)/t16-/m0/s1	SHJHFQYWYVJZEA-INIZCTEOSA-N	258944	US9499502, 9as	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258944&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094874	350083646							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336467	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)C(F)F)ccc1F	InChI=1S/C15H18F3N3O3S/c1-14(2)13(19)21-15(3,7-25(14,23)24)9-6-8(4-5-10(9)16)20-12(22)11(17)18/h4-6,11H,7H2,1-3H3,(H2,19,21)(H,20,22)/t15-/m0/s1	KZHHGWZRVHNVGN-HNNXBMFYSA-N	258946	US9499502, 9au	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258946&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562958	350083648							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336468	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)C2CCOCC2)ccc1F	InChI=1S/C19H26FN3O4S/c1-18(2)17(21)23-19(3,11-28(18,25)26)14-10-13(4-5-15(14)20)22-16(24)12-6-8-27-9-7-12/h4-5,10,12H,6-9,11H2,1-3H3,(H2,21,23)(H,22,24)/t19-/m0/s1	UBRUXOAFMGEIQY-IBGZPJMESA-N	258947	US9499502, 9av	Beta-secretase 2		 2025						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258947&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094880	350083649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336469	CC1(CC1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H23F2N3O3S/c1-16(2)14(21)23-18(4,9-27(16,25)26)11-7-10(8-12(19)13(11)20)22-15(24)17(3)5-6-17/h7-8H,5-6,9H2,1-4H3,(H2,21,23)(H,22,24)/t18-/m0/s1	DBIGIUKPZQRNDS-SFHVURJKSA-N	258950	US9499502, 9az	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258950&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094954	350083652							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336470	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)CC(F)(F)F)cc(F)c1F	InChI=1S/C16H18F5N3O3S/c1-14(2)13(22)24-15(3,7-28(14,26)27)9-4-8(5-10(17)12(9)18)23-11(25)6-16(19,20)21/h4-5H,6-7H2,1-3H3,(H2,22,24)(H,23,25)/t15-/m0/s1	FSJATKPMYQTPNW-HNNXBMFYSA-N	258952	US9499502, 9bc	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258952&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094946	350083654							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336471	CCC(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H21F2N3O3S/c1-5-12(22)20-9-6-10(13(18)11(17)7-9)16(4)8-25(23,24)15(2,3)14(19)21-16/h6-7H,5,8H2,1-4H3,(H2,19,21)(H,20,22)/t16-/m0/s1	DGNMTVLFVQICAX-INIZCTEOSA-N	258954	US9499502, 9be	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258954&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094948	350083656							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336472	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)C2(CC2)C#N)cc(F)c1F	InChI=1S/C18H20F2N4O3S/c1-16(2)14(22)24-17(3,9-28(16,26)27)11-6-10(7-12(19)13(11)20)23-15(25)18(8-21)4-5-18/h6-7H,4-5,9H2,1-3H3,(H2,22,24)(H,23,25)/t17-/m0/s1	XFNPKMCWGFQSND-KRWDZBQOSA-N	258959	US9499502, 9bj	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258959&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094963	350083661							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336473	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)[C@H]2CCCO2)cc(F)c1F	InChI=1S/C18H23F2N3O4S/c1-17(2)16(21)23-18(3,9-28(17,25)26)11-7-10(8-12(19)14(11)20)22-15(24)13-5-4-6-27-13/h7-8,13H,4-6,9H2,1-3H3,(H2,21,23)(H,22,24)/t13-,18+/m1/s1	NYKPPWOSEHBBRT-ACJLOTCBSA-N	258962	US9499502, 9bm	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258962&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563058	350083664							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336474	CC(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C15H19F2N3O3S/c1-8(21)19-9-5-10(12(17)11(16)6-9)15(4)7-24(22,23)14(2,3)13(18)20-15/h5-6H,7H2,1-4H3,(H2,18,20)(H,19,21)/t15-/m0/s1	KUJNPRLBIAHYQF-HNNXBMFYSA-N	258963	US9499502, 9bn	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258963&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563059	350083665							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336475	CC1(COC1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H23F2N3O4S/c1-16(2)14(21)23-18(4,9-28(16,25)26)11-5-10(6-12(19)13(11)20)22-15(24)17(3)7-27-8-17/h5-6H,7-9H2,1-4H3,(H2,21,23)(H,22,24)/t18-/m0/s1	PSMAONNLLQTXNR-SFHVURJKSA-N	258965	US9499502, 9bp	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258965&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563061	350083667							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336476	Cc1noc(CC(=O)Nc2cc(F)c(F)c(c2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)n1	InChI=1S/C18H21F2N5O4S/c1-9-22-14(29-25-9)7-13(26)23-10-5-11(15(20)12(19)6-10)18(4)8-30(27,28)17(2,3)16(21)24-18/h5-6H,7-8H2,1-4H3,(H2,21,24)(H,23,26)/t18-/m0/s1	WANKPVKAERHOSW-SFHVURJKSA-N	258966	US9499502, 9bq	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258966&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094959	350083668							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336477	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)C2CCC2(F)F)cc(F)c1F	InChI=1S/C18H21F4N3O3S/c1-16(2)15(23)25-17(3,8-29(16,27)28)11-6-9(7-12(19)13(11)20)24-14(26)10-4-5-18(10,21)22/h6-7,10H,4-5,8H2,1-3H3,(H2,23,25)(H,24,26)/t10?,17-/m0/s1	ODFQLKLNTCZZTK-LKDXBUKQSA-N	258967	US9499502, 9br	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258967&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094952	350083669							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336478	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccno2)cc(F)c1F	InChI=1S/C17H18F2N4O4S/c1-16(2)15(20)23-17(3,8-28(16,25)26)10-6-9(7-11(18)13(10)19)22-14(24)12-4-5-21-27-12/h4-7H,8H2,1-3H3,(H2,20,23)(H,22,24)/t17-/m0/s1	HGCVJIPWAJOPOR-KRWDZBQOSA-N	258968	US9499502, 9bs	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258968&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094957	350083670							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336479	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)C2CCC2)cc(F)c1F	InChI=1S/C18H23F2N3O3S/c1-17(2)16(21)23-18(3,9-27(17,25)26)12-7-11(8-13(19)14(12)20)22-15(24)10-5-4-6-10/h7-8,10H,4-6,9H2,1-3H3,(H2,21,23)(H,22,24)/t18-/m0/s1	YTCKFTQCOKLTKM-SFHVURJKSA-N	258969	US9499502, 9bt	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258969&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094965	350083671							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336480	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)CC2CC2)cc(F)c1F	InChI=1S/C18H23F2N3O3S/c1-17(2)16(21)23-18(3,9-27(17,25)26)12-7-11(8-13(19)15(12)20)22-14(24)6-10-4-5-10/h7-8,10H,4-6,9H2,1-3H3,(H2,21,23)(H,22,24)/t18-/m0/s1	QVYWFJDBOFQKMZ-SFHVURJKSA-N	258971	US9499502, 9bv	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258971&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094953	350083673							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336481	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)Cc2ncccn2)cc(F)c1F	InChI=1S/C19H21F2N5O3S/c1-18(2)17(22)26-19(3,10-30(18,28)29)12-7-11(8-13(20)16(12)21)25-15(27)9-14-23-5-4-6-24-14/h4-8H,9-10H2,1-3H3,(H2,22,26)(H,25,27)/t19-/m0/s1	VUIFAVGXNNGYBU-IBGZPJMESA-N	258972	US9499502, 9bx	Beta-secretase 2		 2525						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258972&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563156	350083674							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336482	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1nc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H19ClFN5O3S/c1-17(2)16(21)25-18(3,9-29(17,27)28)14-11(20)5-7-13(23-14)24-15(26)12-6-4-10(19)8-22-12/h4-8H,9H2,1-3H3,(H2,21,25)(H,23,24,26)/t18-/m0/s1	BAHYIASQOBRVHX-SFHVURJKSA-N	258977	US9499502, 9cc	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258977&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095134	350083679							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336483	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1nc(NC(=O)c2cnc(Br)cn2)ccc1F	InChI=1S/C17H18BrFN6O3S/c1-16(2)15(20)25-17(3,8-29(16,27)28)13-9(19)4-5-12(23-13)24-14(26)10-6-22-11(18)7-21-10/h4-7H,8H2,1-3H3,(H2,20,25)(H,23,24,26)/t17-/m0/s1	QBSGZXQRNUYHPP-KRWDZBQOSA-N	258985	US9499502, 9ck	Beta-secretase 2		<10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258985&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095273	350083687							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336484	C[C@]1(CS(=O)(=O)C(C)(N)C(=N)N1)c1nc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C18H18FN7O3S/c1-17(9-30(28,29)18(2,22)16(21)26-17)14-11(19)4-6-13(24-14)25-15(27)12-5-3-10(7-20)8-23-12/h3-6,8H,9,22H2,1-2H3,(H2,21,26)(H,24,25,27)/t17-,18?/m0/s1	RUWKWKGKMMNQGR-ZENAZSQFSA-N	258976	US9499502, 9cb	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258976&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953973	350083678							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336485	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H19F2N5O3S/c1-17(2)16(21)25-18(3,9-29(17,27)28)14-11(20)5-7-13(23-14)24-15(26)12-6-4-10(19)8-22-12/h4-8H,9H2,1-3H3,(H2,21,25)(H,23,24,26)/t18-/m0/s1	QTQYBOATYGMCRW-SFHVURJKSA-N	258978	US9499502, 9cd	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258978&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095367	350083680							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336486	COc1ccc(nc1)C(=O)Nc1ccc(F)c(n1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H22FN5O4S/c1-18(2)17(21)25-19(3,10-30(18,27)28)15-12(20)6-8-14(23-15)24-16(26)13-7-5-11(29-4)9-22-13/h5-9H,10H2,1-4H3,(H2,21,25)(H,23,24,26)/t19-/m0/s1	MSVXRFUWKWRUDP-IBGZPJMESA-N	258979	US9499502, 9ce	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258979&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094939	350083681							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336487	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc(NC(=O)c2ccncn2)ccc1F	InChI=1S/C17H19FN6O3S/c1-16(2)15(19)24-17(3,8-28(16,26)27)13-10(18)4-5-12(22-13)23-14(25)11-6-7-20-9-21-11/h4-7,9H,8H2,1-3H3,(H2,19,24)(H,22,23,25)/t17-/m0/s1	OSRDEORLLAUSAY-KRWDZBQOSA-N	258982	US9499502, 9ch	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258982&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095363	350083684							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336488	CC[C@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(OC)cn2)ccc1F	InChI=1S/C21H25FN4O4S/c1-5-21(3)19(23)26-20(2,12-31(21,28)29)15-10-13(6-8-16(15)22)25-18(27)17-9-7-14(30-4)11-24-17/h6-11H,5,12H2,1-4H3,(H2,23,26)(H,25,27)/t20-,21+/m0/s1	VLFYEOKWTIJOJW-LEWJYISDSA-N	258989	US9499502, 9cm-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258989&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095275	350083691							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336489	CC[C@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2cnc(OC)cn2)ccc1F	InChI=1S/C20H24FN5O4S/c1-5-20(3)18(22)26-19(2,11-31(20,28)29)13-8-12(6-7-14(13)21)25-17(27)15-9-24-16(30-4)10-23-15/h6-10H,5,11H2,1-4H3,(H2,22,26)(H,25,27)/t19-,20+/m0/s1	LKFHXZDIEUQXTP-VQTJNVASSA-N	258991	US9499502, 9cn-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258991&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095543	350083693							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336490	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C2CC2)C(=N)N1	InChI=1S/C21H24FN5O4S/c1-20(11-32(29,30)21(2,12-4-5-12)19(23)27-20)14-8-13(6-7-15(14)22)26-18(28)16-9-25-17(31-3)10-24-16/h6-10,12H,4-5,11H2,1-3H3,(H2,23,27)(H,26,28)/t20-,21+/m0/s1	YJOQTCQWWUCODO-LEWJYISDSA-N	258995	US9499502, 9cq-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258995&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094904	350083697							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336491	COc1cccc2cc([nH]c12)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC2CCOCC2)C(=N)N1			258999	US9499502, 9cu-a	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258999&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094897	350083701							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336492	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C23H21F2N5O3S/c1-22(13-34(32,33)23(2,21(26)30-22)19-5-3-4-10-27-19)16-11-15(7-8-17(16)25)29-20(31)18-9-6-14(24)12-28-18/h3-12H,13H2,1-2H3,(H2,26,30)(H,29,31)/t22-,23+/m0/s1	NJTYDCSGUKEPCM-XZOQPEGZSA-N	259001	US9499502, 9cv-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259001&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094902	350083703							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336493	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C23H21ClFN5O3S/c1-22(13-34(32,33)23(2,21(26)30-22)19-5-3-4-10-27-19)16-11-15(7-8-17(16)25)29-20(31)18-9-6-14(24)12-28-18/h3-12H,13H2,1-2H3,(H2,26,30)(H,29,31)/t22-,23+/m0/s1	SSWZFIYACUIXCL-XZOQPEGZSA-N	259003	US9499502, 9cw-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259003&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094964	350083705							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336494	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1	InChI=1S/C23H23FN6O4S/c1-22(13-35(32,33)23(2,21(25)30-22)18-6-4-5-9-26-18)15-10-14(7-8-16(15)24)29-20(31)17-11-28-19(34-3)12-27-17/h4-12H,13H2,1-3H3,(H2,25,30)(H,29,31)/t22-,23-/m0/s1	PFXDNXJLQKPFSP-GOTSBHOMSA-N	259006	US9499502, 9cy-a	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259006&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094925	350083708							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336495	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C24H21F4N5O3S/c1-22(13-37(35,36)23(2,21(29)33-22)19-5-3-4-10-30-19)16-11-15(7-8-17(16)25)32-20(34)18-9-6-14(12-31-18)24(26,27)28/h3-12H,13H2,1-2H3,(H2,29,33)(H,32,34)/t22-,23-/m0/s1	FTPDLNWRRSBALK-GOTSBHOMSA-N	259008	US9499502, 9cz-a	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259008&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094962	350083710							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336496	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(F)c1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H21F3N4O3S/c1-23(13-35(33,34)24(2,22(28)31-23)14-4-3-5-15(25)10-14)18-11-17(7-8-19(18)27)30-21(32)20-9-6-16(26)12-29-20/h3-12H,13H2,1-2H3,(H2,28,31)(H,30,32)/t23-,24+/m0/s1	PRMNIEKLGGVFHS-BJKOFHAPSA-N	259011	US9499502, 9da-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259011&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094915	350083713							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336497	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(F)c1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H21ClF2N4O3S/c1-23(13-35(33,34)24(2,22(28)31-23)14-4-3-5-16(26)10-14)18-11-17(7-8-19(18)27)30-21(32)20-9-6-15(25)12-29-20/h3-12H,13H2,1-2H3,(H2,28,31)(H,30,32)/t23-,24+/m0/s1	KEQJGRSKJJVNOG-BJKOFHAPSA-N	259013	US9499502, 9db-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259013&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094914	350083715							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336498	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1	InChI=1S/C25H24F2N4O4S/c1-24(14-36(33,34)25(2,23(28)31-24)15-5-4-6-16(26)11-15)19-12-17(7-9-20(19)27)30-22(32)21-10-8-18(35-3)13-29-21/h4-13H,14H2,1-3H3,(H2,28,31)(H,30,32)/t24-,25-/m0/s1	LQELPBBEOLZTLK-DQEYMECFSA-N	259014	US9499502, 9dc-a	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259014&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094942	350083716							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336499	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccc(F)cc1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H21F3N4O3S/c1-23(13-35(33,34)24(2,22(28)31-23)14-3-5-15(25)6-4-14)18-11-17(8-9-19(18)27)30-21(32)20-10-7-16(26)12-29-20/h3-12H,13H2,1-2H3,(H2,28,31)(H,30,32)/t23-,24+/m0/s1	VVJCOAYBPYZDAC-BJKOFHAPSA-N	259021	US9499502, 9df-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259021&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095307	350083723							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336500	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(CC2CC2)C(=N)N1	InChI=1S/C22H26FN5O4S/c1-21(12-33(30,31)22(2,20(24)28-21)9-13-4-5-13)15-8-14(6-7-16(15)23)27-19(29)17-10-26-18(32-3)11-25-17/h6-8,10-11,13H,4-5,9,12H2,1-3H3,(H2,24,28)(H,27,29)/t21-,22+/m0/s1	JLERBPKGLVBCHL-FCHUYYIVSA-N	259031	US9499502, 9dk-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259031&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138964	350083733							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336501	C[C@]1(CS(=O)(=O)[C@](C)(CC2CC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C23H24F4N4O3S/c1-21(12-35(33,34)22(2,20(28)31-21)10-13-3-4-13)16-9-15(6-7-17(16)24)30-19(32)18-8-5-14(11-29-18)23(25,26)27/h5-9,11,13H,3-4,10,12H2,1-2H3,(H2,28,31)(H,30,32)/t21-,22+/m0/s1	YOULZVFEEDUUAK-FCHUYYIVSA-N	259033	US9499502, 9dl-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259033&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095369	350083735							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336502	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(CC=C)C(=N)N1	InChI=1S/C21H24FN5O4S/c1-5-8-21(3)19(23)27-20(2,12-32(21,29)30)14-9-13(6-7-15(14)22)26-18(28)16-10-25-17(31-4)11-24-16/h5-7,9-11H,1,8,12H2,2-4H3,(H2,23,27)(H,26,28)/t20-,21+/m0/s1	ZUJKHLJVNCJGJC-LEWJYISDSA-N	259035	US9499502, 9dm-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259035	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259035&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90138889	350083737							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336503	C[C@]1(CS(=O)(=O)[C@](C)(CC(F)(F)F)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H19F5N4O3S/c1-18(10-33(31,32)19(2,17(26)29-18)9-20(23,24)25)13-7-12(4-5-14(13)22)28-16(30)15-6-3-11(21)8-27-15/h3-8H,9-10H2,1-2H3,(H2,26,29)(H,28,30)/t18-,19+/m0/s1	MYEBJZKTHZULPN-RBUKOAKNSA-N	259040	US9499502, 9dp-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259040&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095044	350083742							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336504	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(CC(F)(F)F)C(=N)N1	InChI=1S/C21H22F4N4O4S/c1-19(11-34(31,32)20(2,18(26)29-19)10-21(23,24)25)14-8-12(4-6-15(14)22)28-17(30)16-7-5-13(33-3)9-27-16/h4-9H,10-11H2,1-3H3,(H2,26,29)(H,28,30)/t19-,20+/m0/s1	STIIUEJIVDAURY-VQTJNVASSA-N	259042	US9499502, 9dq-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259042&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095045	350083744							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336505	C[C@]1(CS(=O)(=O)[C@](C)(C2CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H24F2N4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)13-4-3-5-13)16-10-15(7-8-17(16)24)27-19(29)18-9-6-14(23)11-26-18/h6-11,13H,3-5,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22+/m0/s1	UOWARJUDEUSHQR-FCHUYYIVSA-N	259049	US9499502, 9dv-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259049&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095056	350083751							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336506	C[C@]1(CS(=O)(=O)[C@](C)(C2CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H24ClFN4O3S/c1-21(12-32(30,31)22(2,20(25)28-21)13-4-3-5-13)16-10-15(7-8-17(16)24)27-19(29)18-9-6-14(23)11-26-18/h6-11,13H,3-5,12H2,1-2H3,(H2,25,28)(H,27,29)/t21-,22+/m0/s1	VMLHVAKZZJPKPK-FCHUYYIVSA-N	259051	US9499502, 9dw-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259051&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095057	350083753							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336507	CC(C)[C@]1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H24F2N4O3S/c1-12(2)21(4)19(24)27-20(3,11-31(21,29)30)15-9-14(6-7-16(15)23)26-18(28)17-8-5-13(22)10-25-17/h5-10,12H,11H2,1-4H3,(H2,24,27)(H,26,28)/t20-,21+/m0/s1	KIIPFTKRIFPZBX-LEWJYISDSA-N	259059	US9499502, 9ea-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259059&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095087	350083761							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336508	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(C)C)C(=N)N1	InChI=1S/C21H26FN5O4S/c1-12(2)21(4)19(23)27-20(3,11-32(21,29)30)14-8-13(6-7-15(14)22)26-18(28)16-9-25-17(31-5)10-24-16/h6-10,12H,11H2,1-5H3,(H2,23,27)(H,26,28)/t20-,21-/m0/s1	LXQOIJMPBHGPMD-SFTDATJTSA-N	259062	US9499502, 9ec-a	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259062&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095080	350083764							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336509	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C(=N)N1)c1cc(ccn1)C(F)(F)F	InChI=1S/C24H22F4N6O4S/c1-22(15-9-14(4-5-16(15)25)33-20(35)17-10-32-19(38-3)11-31-17)12-39(36,37)23(2,21(29)34-22)18-8-13(6-7-30-18)24(26,27)28/h4-11H,12H2,1-3H3,(H2,29,34)(H,33,35)/t22-,23-/m0/s1	HSZFAIAMGODYEK-GOTSBHOMSA-N	259067	US9499502, 9ee-b	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259067&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953975	350083768							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336510	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1	InChI=1S/C24H24FN5O4S/c1-23(14-35(32,33)24(2,22(26)30-23)20-6-4-5-11-27-20)17-12-15(7-9-18(17)25)29-21(31)19-10-8-16(34-3)13-28-19/h4-13H,14H2,1-3H3,(H2,26,30)(H,29,31)/t23-,24+/m0/s1	YIRVRVGMVDIEGI-BJKOFHAPSA-N	259005	US9499502, 9cx-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259005&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094924	350083707							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336511	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1	InChI=1S/C23H23FN6O4S/c1-22(13-35(32,33)23(2,21(25)30-22)18-6-4-5-9-26-18)15-10-14(7-8-16(15)24)29-20(31)17-11-28-19(34-3)12-27-17/h4-12H,13H2,1-3H3,(H2,25,30)(H,29,31)/t22-,23+/m0/s1	PFXDNXJLQKPFSP-XZOQPEGZSA-N	259007	US9499502, 9cy-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259007&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094908	350083709							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336512	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccn1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C24H21F4N5O3S/c1-22(13-37(35,36)23(2,21(29)33-22)19-5-3-4-10-30-19)16-11-15(7-8-17(16)25)32-20(34)18-9-6-14(12-31-18)24(26,27)28/h3-12H,13H2,1-2H3,(H2,29,33)(H,32,34)/t22-,23+/m0/s1	FTPDLNWRRSBALK-XZOQPEGZSA-N	259009	US9499502, 9cz-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259009&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094921	350083711							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336513	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(F)c1	InChI=1S/C24H23F2N5O4S/c1-23(13-36(33,34)24(2,22(27)31-23)14-5-4-6-15(25)9-14)17-10-16(7-8-18(17)26)30-21(32)19-11-29-20(35-3)12-28-19/h4-12H,13H2,1-3H3,(H2,27,31)(H,30,32)/t23-,24+/m0/s1	TWYSRUPDRPYBJC-BJKOFHAPSA-N	259017	US9499502, 9dd-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259017&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094970	350083719							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336514	C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1cccc(F)c1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C25H21F5N4O3S/c1-23(13-38(36,37)24(2,22(31)34-23)14-4-3-5-16(26)10-14)18-11-17(7-8-19(18)27)33-21(35)20-9-6-15(12-32-20)25(28,29)30/h3-12H,13H2,1-2H3,(H2,31,34)(H,33,35)/t23-,24+/m0/s1	TUMLJMNTYBWVIP-BJKOFHAPSA-N	259019	US9499502, 9de-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259019&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094969	350083721							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336515	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccc(F)cc1	InChI=1S/C24H23F2N5O4S/c1-23(13-36(33,34)24(2,22(27)31-23)14-4-6-15(25)7-5-14)17-10-16(8-9-18(17)26)30-21(32)19-11-29-20(35-3)12-28-19/h4-12H,13H2,1-3H3,(H2,27,31)(H,30,32)/t23-,24+/m0/s1	QJTNVDROEBMADB-BJKOFHAPSA-N	259023	US9499502, 9dg-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259023&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095308	350083725							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336516	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(CC(F)(F)F)C(=N)N1	InChI=1S/C20H21F4N5O4S/c1-18(10-34(31,32)19(2,17(25)29-18)9-20(22,23)24)12-6-11(4-5-13(12)21)28-16(30)14-7-27-15(33-3)8-26-14/h4-8H,9-10H2,1-3H3,(H2,25,29)(H,28,30)/t18-,19+/m0/s1	AAWWARFYZYVELF-RBUKOAKNSA-N	259044	US9499502, 9dr-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259044&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095046	350083746							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336517	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C2CCC2)C(=N)N1	InChI=1S/C23H27FN4O4S/c1-22(13-33(30,31)23(2,21(25)28-22)14-5-4-6-14)17-11-15(7-9-18(17)24)27-20(29)19-10-8-16(32-3)12-26-19/h7-12,14H,4-6,13H2,1-3H3,(H2,25,28)(H,27,29)/t22-,23+/m0/s1	BXZFFECLBOOHGF-XZOQPEGZSA-N	259053	US9499502, 9dx-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259053&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095053	350083755							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336518	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@](C)(C2CCC2)C(=N)N1	InChI=1S/C22H26FN5O4S/c1-21(12-33(30,31)22(2,20(24)28-21)13-5-4-6-13)15-9-14(7-8-16(15)23)27-19(29)17-10-26-18(32-3)11-25-17/h7-11,13H,4-6,12H2,1-3H3,(H2,24,28)(H,27,29)/t21-,22+/m0/s1	YZOGZKNAXGTHLN-FCHUYYIVSA-N	259055	US9499502, 9dy-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259055&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095054	350083757							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
336519	C[C@]1(CS(=O)(=O)[C@](C)(C2CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C23H24F4N4O3S/c1-21(12-35(33,34)22(2,20(28)31-21)13-4-3-5-13)16-10-15(7-8-17(16)24)30-19(32)18-9-6-14(11-29-18)23(25,26)27/h6-11,13H,3-5,12H2,1-2H3,(H2,28,31)(H,30,32)/t21-,22+/m0/s1	XLKKPKIXUHYZCJ-FCHUYYIVSA-N	259057	US9499502, 9dz-b	Beta-secretase 2		 400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259057&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095079	350083759							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341360	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C13H16FN3O2S/c1-12(9-6-8(15)2-3-10(9)14)7-20(18,19)13(4-5-13)11(16)17-12/h2-3,6H,4-5,7,15H2,1H3,(H2,16,17)/t12-/m0/s1	KTPOWCHYJRYHCA-LBPRGKRZSA-N	190871	US9181236, Table A, 7	Beta-secretase 2		 1864						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190871&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419828	316936143							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341361	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(ccc1F)[N+]([O-])=O	InChI=1S/C14H16FN3O4S/c1-13(10-7-9(18(19)20)3-4-11(10)15)8-23(21,22)14(5-2-6-14)12(16)17-13/h3-4,7H,2,5-6,8H2,1H3,(H2,16,17)/t13-/m0/s1	IZCTVCBOWSLGFL-ZDUSSCGKSA-N	190872	US9181236, Table A, 11	Beta-secretase 2		 3205						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190872&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419880	316936144							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341362	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C14H18FN3O2S/c1-13(10-7-9(16)3-4-11(10)15)8-21(19,20)14(5-2-6-14)12(17)18-13/h3-4,7H,2,5-6,8,16H2,1H3,(H2,17,18)/t13-/m0/s1	TXHYXJVVXMUHIJ-ZDUSSCGKSA-N	190873	US9181236, Table A, 12	Beta-secretase 2		 3967						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190873&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419882	316936145							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341363	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(ccc1F)[N+]([O-])=O	InChI=1S/C15H18FN3O4S/c1-14(11-8-10(19(20)21)4-5-12(11)16)9-24(22,23)15(13(17)18-14)6-2-3-7-15/h4-5,8H,2-3,6-7,9H2,1H3,(H2,17,18)/t14-/m0/s1	AMKVFRZWMZCNRI-AWEZNQCLSA-N	190874	US9181236, Table A, 16	Beta-secretase 2		 734						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190874&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419819	316936146							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341364	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C15H20FN3O2S/c1-14(11-8-10(17)4-5-12(11)16)9-22(20,21)15(13(18)19-14)6-2-3-7-15/h4-5,8H,2-3,6-7,9,17H2,1H3,(H2,18,19)/t14-/m0/s1	JNDSMEHECBJJHD-AWEZNQCLSA-N	190875	US9181236, Table A, 17	Beta-secretase 2		 1421						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190875&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419817	316936147							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341365	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C16H22FN3O2S/c1-15(12-9-11(18)5-6-13(12)17)10-23(21,22)16(14(19)20-15)7-3-2-4-8-16/h5-6,9H,2-4,7-8,10,18H2,1H3,(H2,19,20)/t15-/m0/s1	WWGYWODVFGIRNA-HNNXBMFYSA-N	190877	US9181236, Table A, 22	Beta-secretase 2		 2802						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419847	316936148							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341366	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1cc(N)ccc1F	InChI=1S/C15H20FN3O3S/c1-14(11-8-10(17)2-3-12(11)16)9-23(20,21)15(13(18)19-14)4-6-22-7-5-15/h2-3,8H,4-7,9,17H2,1H3,(H2,18,19)/t14-/m0/s1	YQALLQRXKKZOEZ-AWEZNQCLSA-N	190879	US9181236, Table A, 27	Beta-secretase 2		 3584						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190879&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419829	316936149							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341367	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(Br)ccc1F	InChI=1S/C15H18BrFN2O2S/c1-14(11-8-10(16)4-5-12(11)17)9-22(20,21)15(13(18)19-14)6-2-3-7-15/h4-5,8H,2-3,6-7,9H2,1H3,(H2,18,19)/t14-/m0/s1	MGIAHZQTXAWEJX-AWEZNQCLSA-N	190880	US9181236, Table A, 31	Beta-secretase 2		 935						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190880&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86715771	316936150							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341368	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1sc(Br)cc1Cl	InChI=1S/C13H16BrClN2O2S2/c1-12(10-8(15)6-9(14)20-10)7-21(18,19)13(11(16)17-12)4-2-3-5-13/h6H,2-5,7H2,1H3,(H2,16,17)/t12-/m0/s1	GRAFXIWCUXYBKL-LBPRGKRZSA-N	190881	US9181236, Table A, 35	Beta-secretase 2		 134						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190881&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419821	316936151							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341369	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1sc(Br)cc1Cl	InChI=1S/C14H18BrClN2O2S2/c1-13(11-9(16)7-10(15)21-11)8-22(19,20)14(12(17)18-13)5-3-2-4-6-14/h7H,2-6,8H2,1H3,(H2,17,18)/t13-/m0/s1	NOVZKGZTLQEKLU-ZDUSSCGKSA-N	190882	US9181236, Table A, 38	Beta-secretase 2		 715						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190882&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419884	316936152							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341370	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(Br)cc1Cl	InChI=1S/C13H16BrClN2O3S2/c1-12(10-8(15)6-9(14)21-10)7-22(18,19)13(11(16)17-12)2-4-20-5-3-13/h6H,2-5,7H2,1H3,(H2,16,17)/t12-/m0/s1	BDXWFZLVSDHEQO-LBPRGKRZSA-N	190883	US9181236, Table A, 41	Beta-secretase 2		 1087						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190883&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419849	316936153							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341371	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(Br)cc1Cl	InChI=1S/C12H14BrClN2O2S2/c1-11(9-7(14)5-8(13)19-9)6-20(17,18)12(3-2-4-12)10(15)16-11/h5H,2-4,6H2,1H3,(H2,15,16)/t11-/m0/s1	BFFXPMHURKDIDG-NSHDSACASA-N	190884	US9181236, Table A, 44	Beta-secretase 2		 531						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190884&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419848	316936154							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341372	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1cc(ccc1Cl)[N+]([O-])=O	InChI=1S/C14H16ClN3O5S/c1-13(10-6-9(18(19)20)2-3-11(10)15)8-24(21,22)14(12(16)17-13)4-5-23-7-14/h2-3,6H,4-5,7-8H2,1H3,(H2,16,17)/t13-,14-/m0/s1	AQRLJLANHUYILO-KBPBESRZSA-N	190885	US9181236, Table A, 14-4	Beta-secretase 2		 2078						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190885&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90287191	316936155							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341373	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1cc(N)ccc1Cl	InChI=1S/C14H18ClN3O3S/c1-13(10-6-9(16)2-3-11(10)15)8-22(19,20)14(12(17)18-13)4-5-21-7-14/h2-3,6H,4-5,7-8,16H2,1H3,(H2,17,18)/t13-,14-/m0/s1	IDSDTWJEZXHWKO-KBPBESRZSA-N	190886	US9181236, Table A, 14-5	Beta-secretase 2		 5106						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190886&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90287192	316936156							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341374	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1cc(ccc1Cl)[N+]([O-])=O	InChI=1S/C14H16ClN3O5S/c1-13(10-6-9(18(19)20)2-3-11(10)15)8-24(21,22)14(12(16)17-13)4-5-23-7-14/h2-3,6H,4-5,7-8H2,1H3,(H2,16,17)/t13-,14+/m0/s1	AQRLJLANHUYILO-UONOGXRCSA-N	190887	US9181236, Table A, 14-7	Beta-secretase 2		 2669						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190887&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90287193	316936157							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341375	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1cc(N)ccc1Cl	InChI=1S/C14H18ClN3O3S/c1-13(10-6-9(16)2-3-11(10)15)8-22(19,20)14(12(17)18-13)4-5-21-7-14/h2-3,6H,4-5,7-8,16H2,1H3,(H2,17,18)/t13-,14+/m0/s1	IDSDTWJEZXHWKO-UONOGXRCSA-N	190888	US9181236, Table A, 14-8	Beta-secretase 2		 3818						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190888&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90287194	316936158							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341376	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1sc(Br)cc1Cl	InChI=1S/C11H12BrClN2O2S2/c1-10(8-6(13)4-7(12)18-8)5-19(16,17)11(2-3-11)9(14)15-10/h4H,2-3,5H2,1H3,(H2,14,15)/t10-/m0/s1	ZNZPZRPWPPCIGM-JTQLQIEISA-N	190889	US9181236, Table A, 15-3	Beta-secretase 2		 465						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190889&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419818	316936159							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341377	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H18ClFN4O3S/c1-18(10-29(27,28)19(6-7-19)17(22)25-18)13-8-12(3-4-14(13)21)24-16(26)15-5-2-11(20)9-23-15/h2-5,8-9H,6-7,10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1	PFXZPNOPENCWPS-SFHVURJKSA-N	190697	US9181236, 1	Beta-secretase 2		 0.4						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190697	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190697&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71531923	316935986							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341378	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H18F2N4O3S/c1-18(10-29(27,28)19(6-7-19)17(22)25-18)13-8-12(3-4-14(13)21)24-16(26)15-5-2-11(20)9-23-15/h2-5,8-9H,6-7,10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1	NBFRITZBPLSEGT-SFHVURJKSA-N	190699	US9181236, 3	Beta-secretase 2		 0.9						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190699	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190699&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71531969	316935988							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341379	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1cc(NC(=O)c2ncc(F)cc2F)ccc1F	InChI=1S/C19H17F3N4O3S/c1-18(9-30(28,29)19(4-5-19)17(23)26-18)12-7-11(2-3-13(12)21)25-16(27)15-14(22)6-10(20)8-24-15/h2-3,6-8H,4-5,9H2,1H3,(H2,23,26)(H,25,27)/t18-/m0/s1	VYCNPKFZLDVGGK-SFHVURJKSA-N	190700	US9181236, 4	Beta-secretase 2		 0.5						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190700	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190700&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71531970	316935989							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341380	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CC2)C(=N)N1	InChI=1S/C20H21FN4O4S/c1-19(11-30(27,28)20(7-8-20)18(22)25-19)14-9-12(3-5-15(14)21)24-17(26)16-6-4-13(29-2)10-23-16/h3-6,9-10H,7-8,11H2,1-2H3,(H2,22,25)(H,24,26)/t19-/m0/s1	XAGKPFWKUPZWQJ-IBGZPJMESA-N	190701	US9181236, 5	Beta-secretase 2		 1.9						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190701	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190701&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71531971	316935990							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341381	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H20ClFN4O3S/c1-19(11-30(28,29)20(7-2-8-20)18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1	PLKVYHMTQHLCFY-IBGZPJMESA-N	190702	US9181236, 6	Beta-secretase 2		 1.9						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190702	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190702&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419854	316935991							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341382	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N4O3S/c1-19(11-30(28,29)20(7-2-8-20)18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1	XWJUDLOWAPGUSX-IBGZPJMESA-N	190704	US9181236, 8	Beta-secretase 2		 4.2						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190704	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190704&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419855	316935993							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341383	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(NC(=O)c2ncc(F)cc2F)ccc1F	InChI=1S/C20H19F3N4O3S/c1-19(10-31(29,30)20(5-2-6-20)18(24)27-19)13-8-12(3-4-14(13)22)26-17(28)16-15(23)7-11(21)9-25-16/h3-4,7-9H,2,5-6,10H2,1H3,(H2,24,27)(H,26,28)/t19-/m0/s1	JCFPKSICQRVYPG-IBGZPJMESA-N	190705	US9181236, 9	Beta-secretase 2		 2.5						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190705	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190705&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71531973	316935994							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341384	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H22ClFN4O3S/c1-20(12-31(29,30)21(19(24)27-20)8-2-3-9-21)15-10-14(5-6-16(15)23)26-18(28)17-7-4-13(22)11-25-17/h4-7,10-11H,2-3,8-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1	VFUXKCUHUHFKCF-FQEVSTJZSA-N	190708	US9181236, 12	Beta-secretase 2		 0.3						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190708	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190708&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71511825	316935997							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341385	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H22F2N4O3S/c1-20(12-31(29,30)21(19(24)27-20)8-2-3-9-21)15-10-14(5-6-16(15)23)26-18(28)17-7-4-13(22)11-25-17/h4-7,10-11H,2-3,8-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1	DMEAWTNLOAGORR-FQEVSTJZSA-N	190709	US9181236, 13	Beta-secretase 2		 0.3						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190709	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190709&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419856	316935998							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341386	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C22H22F4N4O3S/c1-20(12-34(32,33)21(19(27)30-20)8-2-3-9-21)15-10-14(5-6-16(15)23)29-18(31)17-7-4-13(11-28-17)22(24,25)26/h4-7,10-11H,2-3,8-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1	SJWYDDZFJMFIGS-FQEVSTJZSA-N	190710	US9181236, 14	Beta-secretase 2		 2.1						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419853	316935999							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341387	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCCC2)C(=N)N1	InChI=1S/C22H25FN4O4S/c1-21(13-32(29,30)22(20(24)27-21)9-3-4-10-22)16-11-14(5-7-17(16)23)26-19(28)18-8-6-15(31-2)12-25-18/h5-8,11-12H,3-4,9-10,13H2,1-2H3,(H2,24,27)(H,26,28)/t21-/m0/s1	YNASOOLPYPKVDC-NRFANRHFSA-N	190711	US9181236, 15	Beta-secretase 2		 0.6						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190711	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190711&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419851	316936000							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341388	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCCC2)C(=N)N1	InChI=1S/C21H24FN5O4S/c1-20(12-32(29,30)21(19(23)27-20)7-3-4-8-21)14-9-13(5-6-15(14)22)26-18(28)16-10-25-17(31-2)11-24-16/h5-6,9-11H,3-4,7-8,12H2,1-2H3,(H2,23,27)(H,26,28)/t20-/m0/s1	GXWQCTDIXFWINS-FQEVSTJZSA-N	190713	US9181236, 17	Beta-secretase 2		 1.5						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190713&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419857	316936002							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341389	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C21H21Cl2FN4O3S/c1-20(11-32(30,31)21(19(25)28-20)6-2-3-7-21)14-9-13(4-5-16(14)24)27-18(29)17-15(23)8-12(22)10-26-17/h4-5,8-10H,2-3,6-7,11H2,1H3,(H2,25,28)(H,27,29)/t20-/m0/s1	MFOWGDZPKDZMAE-FQEVSTJZSA-N	190714	US9181236, 18	Beta-secretase 2		 0.8						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190714	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190714&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532016	316936003							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341390	Cc1nc(no1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCCC2)C(=N)N1	InChI=1S/C19H22FN5O4S/c1-11-22-15(25-29-11)16(26)23-12-5-6-14(20)13(9-12)18(2)10-30(27,28)19(17(21)24-18)7-3-4-8-19/h5-6,9H,3-4,7-8,10H2,1-2H3,(H2,21,24)(H,23,26)/t18-/m0/s1	UHUUJEBNZPATNF-SFHVURJKSA-N	190717	US9181236, 21	Beta-secretase 2		 1.3						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190717&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532018	316936006							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341391	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2ccn(n2)C(F)F)ccc1F	InChI=1S/C20H22F3N5O3S/c1-19(11-32(30,31)20(17(24)26-19)7-2-3-8-20)13-10-12(4-5-14(13)21)25-16(29)15-6-9-28(27-15)18(22)23/h4-6,9-10,18H,2-3,7-8,11H2,1H3,(H2,24,26)(H,25,29)/t19-/m0/s1	LANVFBZXABIOHF-IBGZPJMESA-N	190718	US9181236, 22	Beta-secretase 2		 4.3						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190718&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532019	316936007							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341392	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2cnsn2)ccc1F	InChI=1S/C18H20FN5O3S2/c1-17(10-29(26,27)18(16(20)23-17)6-2-3-7-18)12-8-11(4-5-13(12)19)22-15(25)14-9-21-28-24-14/h4-5,8-9H,2-3,6-7,10H2,1H3,(H2,20,23)(H,22,25)/t17-/m0/s1	DITHWFRPAUJPAT-KRWDZBQOSA-N	190719	US9181236, 23	Beta-secretase 2		 3.1						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190719&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532068	316936008							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341393	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H24F2N4O3S/c1-21(13-32(30,31)22(20(25)28-21)9-3-2-4-10-22)16-11-15(6-7-17(16)24)27-19(29)18-8-5-14(23)12-26-18/h5-8,11-12H,2-4,9-10,13H2,1H3,(H2,25,28)(H,27,29)/t21-/m0/s1	UZZLXHRXTJQCMS-NRFANRHFSA-N	190721	US9181236, 25	Beta-secretase 2		 4.4						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190721	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190721&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419928	316936010							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341394	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H22F2N4O4S/c1-20(12-32(29,30)21(19(24)27-20)6-8-31-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1	KDPDVNZNYZRPNE-FQEVSTJZSA-N	190726	US9181236, 30	Beta-secretase 2		 2.1						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190726	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190726&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419836	316936015							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341395	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C21H21Cl2FN4O4S/c1-20(11-33(30,31)21(19(25)28-20)4-6-32-7-5-21)14-9-13(2-3-16(14)24)27-18(29)17-15(23)8-12(22)10-26-17/h2-3,8-10H,4-7,11H2,1H3,(H2,25,28)(H,27,29)/t20-/m0/s1	LVQIQZMFZUTHBS-FQEVSTJZSA-N	190727	US9181236, 31	Beta-secretase 2		 1.2						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190727&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532073	316936016							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341396	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H22ClFN4O4S/c1-20(12-32(29,30)21(19(24)27-20)6-8-31-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1	OVIVINBQPWFCIG-FQEVSTJZSA-N	190729	US9181236, 33	Beta-secretase 2		 1.6						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190729	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190729&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419908	316936018							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341397	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F	InChI=1S/C21H21ClF2N4O4S/c1-20(11-33(30,31)21(19(25)28-20)4-6-32-7-5-21)14-9-13(2-3-15(14)23)27-18(29)17-16(24)8-12(22)10-26-17/h2-3,8-10H,4-7,11H2,1H3,(H2,25,28)(H,27,29)/t20-/m0/s1	RDYMLTPWDRZZSE-FQEVSTJZSA-N	190732	US9181236, 35a	Beta-secretase 2		 1.4						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190732&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532115	316936021							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341398	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C19H19ClN4O2S2/c1-18(11-28(25,26)19(17(22)24-18)4-2-3-5-19)16-14(20)7-15(27-16)13-6-12(8-21)9-23-10-13/h6-7,9-10H,2-5,11H2,1H3,(H2,22,24)/t18-/m0/s1	ZWWURSGYFFYEPL-SFHVURJKSA-N	190742	US9181236, 42	Beta-secretase 2		 3.4						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190742&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532170	316936028							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341399	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C2(CCCCC2)C(=N)N1			190745	US9181236, 44	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190745&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532223	316936031							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341400	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C2(CCOCC2)C(=N)N1			190750	US9181236, 48	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190750&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532226	316936036							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341401	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C2(CCC2)C(=N)N1			190761	US9181236, 58	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190761&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419892	316936047							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341402	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N4O4S/c1-19(11-31(28,29)20(18(23)26-19)6-7-30-10-20)14-8-13(3-4-15(14)22)25-17(27)16-5-2-12(21)9-24-16/h2-5,8-9H,6-7,10-11H2,1H3,(H2,23,26)(H,25,27)/t19-,20-/m0/s1	VBGOWSNHHLRKMG-PMACEKPBSA-N	190768	US9181236, 62b	Beta-secretase 2		 4.3						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190768&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419904	316936054							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341403	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)-c1ncco1	InChI=1S/C20H19ClN4O4S2/c1-19(11-31(26,27)20(18(22)25-19)2-4-28-10-20)16-14(21)7-15(30-16)12-6-13(9-23-8-12)17-24-3-5-29-17/h3,5-9H,2,4,10-11H2,1H3,(H2,22,25)/t19-,20-/m0/s1	UZFBWJUQLKQDLI-PMACEKPBSA-N	190774	US9181236, 62h	Beta-secretase 2		 2.8						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190774&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419919	316936060							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341404	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1ccnc(c1)-c1ccco1	InChI=1S/C21H20ClN3O4S2/c1-20(12-31(26,27)21(19(23)25-20)5-8-28-11-21)18-14(22)10-17(30-18)13-4-6-24-15(9-13)16-3-2-7-29-16/h2-4,6-7,9-10H,5,8,11-12H2,1H3,(H2,23,25)/t20-,21-/m0/s1	XMAJTXQDFFTSRK-SFTDATJTSA-N	190778	US9181236, 62l	Beta-secretase 2		 2.2						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190778&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419922	316936064							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341405	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H20ClFN4O4S/c1-19(11-31(28,29)20(18(23)26-19)6-7-30-10-20)14-8-13(3-4-15(14)22)25-17(27)16-5-2-12(21)9-24-16/h2-5,8-9H,6-7,10-11H2,1H3,(H2,23,26)(H,25,27)/t19-,20-/m0/s1	RLICXMNKTDOVDH-PMACEKPBSA-N	190769	US9181236, 62c	Beta-secretase 2		 1.8						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190769	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190769&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419915	316936055							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341406	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1			190773	US9181236, 62g	Beta-secretase 2		 0.9						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190773&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419903	316936059							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341407	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N4O4S/c1-19(11-31(28,29)20(18(23)26-19)6-7-30-10-20)14-8-13(3-4-15(14)22)25-17(27)16-5-2-12(21)9-24-16/h2-5,8-9H,6-7,10-11H2,1H3,(H2,23,26)(H,25,27)/t19-,20+/m0/s1	VBGOWSNHHLRKMG-VQTJNVASSA-N	190783	US9181236, 63b	Beta-secretase 2		 2.7						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419925	316936069							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341408	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1			190787	US9181236, 63f	Beta-secretase 2		 1.5						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190787&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419936	316936073							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341409	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H20ClFN4O4S/c1-19(11-31(28,29)20(18(23)26-19)6-7-30-10-20)14-8-13(3-4-15(14)22)25-17(27)16-5-2-12(21)9-24-16/h2-5,8-9H,6-7,10-11H2,1H3,(H2,23,26)(H,25,27)/t19-,20+/m0/s1	RLICXMNKTDOVDH-VQTJNVASSA-N	190784	US9181236, 63c	Beta-secretase 2		 1.3						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190784&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419932	316936070							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341410	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C2(CC2)C(=N)N1			190796	US9181236, 64	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190796&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532430	316936082							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341411	C[C@]1(CS(=O)(=O)C2(C[C@H](O)C2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N4O4S/c1-19(10-31(29,30)20(18(23)26-19)7-13(27)8-20)14-6-12(3-4-15(14)22)25-17(28)16-5-2-11(21)9-24-16/h2-6,9,13,27H,7-8,10H2,1H3,(H2,23,26)(H,25,28)/t13-,19-,20?/m0/s1	CCUVIHBHXVVLDY-NXAXYOPQSA-N	190807	US9181236, 74	Beta-secretase 2		 3.8						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190807&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532434	316936085							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341412	C[C@]1(CS(=O)(=O)[C@]2(C[C@H](O)C2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N4O4S/c1-19(10-31(29,30)20(18(23)26-19)7-13(27)8-20)14-6-12(3-4-15(14)22)25-17(28)16-5-2-11(21)9-24-16/h2-6,9,13,27H,7-8,10H2,1H3,(H2,23,26)(H,25,28)/t13-,19-,20-/m0/s1	CCUVIHBHXVVLDY-MRFFXTKBSA-N	190808	US9181236, 75	Beta-secretase 2		 1.7						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190808&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532434	316936086							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341413	C[C@]1(CS(=O)(=O)C2(CCC(O)C2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H22F2N4O4S/c1-20(11-32(30,31)21(19(24)27-20)7-6-14(28)9-21)15-8-13(3-4-16(15)23)26-18(29)17-5-2-12(22)10-25-17/h2-5,8,10,14,28H,6-7,9,11H2,1H3,(H2,24,27)(H,26,29)/t14?,20-,21?/m0/s1	PAJSDOHDTCSASR-NAXCRDPKSA-N	190809	US9181236, 76a (isomeric sample 1)::US9181236, 76b (isomeric sample 2)	Beta-secretase 2		 2.4						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190809&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419860	316936087							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341414	C[C@]1(CS(=O)(=O)C2(CCC(O)C2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H22F2N4O4S/c1-20(11-32(30,31)21(19(24)27-20)7-6-14(28)9-21)15-8-13(3-4-16(15)23)26-18(29)17-5-2-12(22)10-25-17/h2-5,8,10,14,28H,6-7,9,11H2,1H3,(H2,24,27)(H,26,29)/t14?,20-,21?/m0/s1	PAJSDOHDTCSASR-NAXCRDPKSA-N	190809	US9181236, 76a (isomeric sample 1)::US9181236, 76b (isomeric sample 2)	Beta-secretase 2		 4						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190809&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419860	316936087							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341415	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(ccc1F)-c1cccc(c1)C#N	InChI=1S/C22H22FN3O2S/c1-21(14-29(27,28)22(20(25)26-21)9-2-3-10-22)18-12-17(7-8-19(18)23)16-6-4-5-15(11-16)13-24/h4-8,11-12H,2-3,9-10,14H2,1H3,(H2,25,26)/t21-/m0/s1	SRFOUNRPSJUNFZ-NRFANRHFSA-N	190734	US9181236, 36	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190734&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532117	316936022							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341416	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(ccc1F)-c1cncc(c1)C#N	InChI=1S/C21H21FN4O2S/c1-20(13-29(27,28)21(19(24)26-20)6-2-3-7-21)17-9-15(4-5-18(17)22)16-8-14(10-23)11-25-12-16/h4-5,8-9,11-12H,2-3,6-7,13H2,1H3,(H2,24,26)/t20-/m0/s1	ZMEFTVWOMQBUQF-FQEVSTJZSA-N	190736	US9181236, 38	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190736&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532119	316936024							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341417	COc1cccc2cc(-c3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)C4(CCCC4)C(=N)N3)n(C(=O)OC(C)(C)C)c12	InChI=1S/C29H34FN3O5S/c1-27(2,3)38-26(34)33-22(16-19-9-8-10-23(37-5)24(19)33)18-11-12-21(30)20(15-18)28(4)17-39(35,36)29(25(31)32-28)13-6-7-14-29/h8-12,15-16H,6-7,13-14,17H2,1-5H3,(H2,31,32)/t28-/m0/s1	XDUCEUMKOUUCCK-NDEPHWFRSA-N	190737	US9181236, 39	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190737&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532166	316936025							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341418	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(ccc1F)-n1cc(nn1)-c1ccccc1	InChI=1S/C22H22FN5O2S/c1-21(14-31(29,30)22(10-5-11-22)20(24)25-21)17-12-16(8-9-18(17)23)28-13-19(26-27-28)15-6-3-2-4-7-15/h2-4,6-9,12-13H,5,10-11,14H2,1H3,(H2,24,25)/t21-/m0/s1	WUPNGFYHCVTMNT-NRFANRHFSA-N	190738	US9181236, 39a	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190738&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532167	316936026							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341419	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(ccc1F)-n1cc(nn1)-c1cccnc1	InChI=1S/C21H21FN6O2S/c1-20(13-31(29,30)21(7-3-8-21)19(23)25-20)16-10-15(5-6-17(16)22)28-12-18(26-27-28)14-4-2-9-24-11-14/h2,4-6,9-12H,3,7-8,13H2,1H3,(H2,23,25)/t20-/m0/s1	HUEBJZZJAJPKSC-FQEVSTJZSA-N	190739	US9181236, 39b	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190739&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532168	316936027							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341420	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1sc(cc1Cl)-c1cncnc1	InChI=1S/C18H21ClN4O2S2/c1-17(15-13(19)7-14(26-15)12-8-21-11-22-9-12)10-27(24,25)18(16(20)23-17)5-3-2-4-6-18/h7-9,11H,2-6,10H2,1H3,(H2,20,23)/t17-/m0/s1	OWTRPCMYHPCVPV-KRWDZBQOSA-N	190748	US9181236, 47	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190748&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532224	316936034							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341421	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cncnc1	InChI=1S/C17H19ClN4O3S2/c1-16(14-12(18)6-13(26-14)11-7-20-10-21-8-11)9-27(23,24)17(15(19)22-16)2-4-25-5-3-17/h6-8,10H,2-5,9H2,1H3,(H2,19,22)/t16-/m0/s1	BQJHRSMLPJPSJI-INIZCTEOSA-N	190753	US9181236, 51	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190753&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532284	316936039							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341422	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)N1CCCC1	InChI=1S/C23H28ClN3O3S2/c1-22(15-32(28,29)23(21(25)26-22)7-11-30-12-8-23)20-18(24)14-19(31-20)16-5-4-6-17(13-16)27-9-2-3-10-27/h4-6,13-14H,2-3,7-12,15H2,1H3,(H2,25,26)/t22-/m0/s1	QMGKLTPSEIERIH-QFIPXVFZSA-N	190758	US9181236, 56	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190758	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190758&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419833	316936044							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341423	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)-c1cncnc1	InChI=1S/C16H17ClN4O2S2/c1-15(8-25(22,23)16(3-2-4-16)14(18)21-15)13-11(17)5-12(24-13)10-6-19-9-20-7-10/h5-7,9H,2-4,8H2,1H3,(H2,18,21)/t15-/m0/s1	ZYXFMVGPCONVBU-HNNXBMFYSA-N	190763	US9181236, 60	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190763	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190763&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532288	316936049							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341424	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)N1CCOCC1	InChI=1S/C21H25ClN4O4S2/c1-20(13-32(27,28)21(19(23)25-20)2-5-30-12-21)18-16(22)9-17(31-18)14-8-15(11-24-10-14)26-3-6-29-7-4-26/h8-11H,2-7,12-13H2,1H3,(H2,23,25)/t20-,21-/m0/s1	IDJVIBIBYDMHQK-SFTDATJTSA-N	190775	US9181236, 62i	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190775&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419920	316936061							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341425	CC(C)(O)c1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1	InChI=1S/C20H24ClN3O4S2/c1-18(2,25)13-6-12(8-23-9-13)15-7-14(21)16(29-15)19(3)11-30(26,27)20(17(22)24-19)4-5-28-10-20/h6-9,25H,4-5,10-11H2,1-3H3,(H2,22,24)/t19-,20-/m0/s1	QSEPSFBUKLXLRB-PMACEKPBSA-N	190779	US9181236, 62m	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190779&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419918	316936065							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341426	CCc1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1	InChI=1S/C19H22ClN3O3S2/c1-3-12-6-13(9-22-8-12)15-7-14(20)16(27-15)18(2)11-28(24,25)19(17(21)23-18)4-5-26-10-19/h6-9H,3-5,10-11H2,1-2H3,(H2,21,23)/t18-,19+/m0/s1	DWVJHGJXHWWCTD-RBUKOAKNSA-N	190790	US9181236, 63i	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190790	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190790&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419912	316936076							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341427	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)N1CCOCC1	InChI=1S/C21H25ClN4O4S2/c1-20(13-32(27,28)21(19(23)25-20)2-5-30-12-21)18-16(22)9-17(31-18)14-8-15(11-24-10-14)26-3-6-29-7-4-26/h8-11H,2-7,12-13H2,1H3,(H2,23,25)/t20-,21+/m0/s1	IDJVIBIBYDMHQK-LEWJYISDSA-N	190791	US9181236, 63j	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190791&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419890	316936077							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341428	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)C#CCN1CCOCC1	InChI=1S/C19H24ClN3O3S2/c1-18(13-28(24,25)19(5-3-6-19)17(21)22-18)16-15(20)12-14(27-16)4-2-7-23-8-10-26-11-9-23/h12H,3,5-11,13H2,1H3,(H2,21,22)/t18-/m0/s1	KBVJHEKCYKVSSI-SFHVURJKSA-N	190815	US9181236, 77d	Beta-secretase 2		<100						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190815&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419868	316936092							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341429	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCCCC2)C(=N)N1	InChI=1S/C22H26FN5O4S/c1-21(13-33(30,31)22(20(24)28-21)8-4-3-5-9-22)15-10-14(6-7-16(15)23)27-19(29)17-11-26-18(32-2)12-25-17/h6-7,10-12H,3-5,8-9,13H2,1-2H3,(H2,24,28)(H,27,29)/t21-/m0/s1	PWJBQDDBAHIPRM-NRFANRHFSA-N	190723	US9181236, 27	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190723	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190723&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532071	316936012							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341430	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C23H24F4N4O3S/c1-21(13-35(33,34)22(20(28)31-21)9-3-2-4-10-22)16-11-15(6-7-17(16)24)30-19(32)18-8-5-14(12-29-18)23(25,26)27/h5-8,11-12H,2-4,9-10,13H2,1H3,(H2,28,31)(H,30,32)/t21-/m0/s1	ZGUSKHFEXNKTRN-NRFANRHFSA-N	190725	US9181236, 29	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190725&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419881	316936014							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341431	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCOCC2)C(=N)N1	InChI=1S/C21H24FN5O5S/c1-20(12-33(29,30)21(19(23)27-20)5-7-32-8-6-21)14-9-13(3-4-15(14)22)26-18(28)16-10-25-17(31-2)11-24-16/h3-4,9-11H,5-8,12H2,1-2H3,(H2,23,27)(H,26,28)/t20-/m0/s1	WMPSIIQUOGDWNZ-FQEVSTJZSA-N	190728	US9181236, 32	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190728&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419883	316936017							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341432	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C22H22F4N4O4S/c1-20(12-35(32,33)21(19(27)30-20)6-8-34-9-7-21)15-10-14(3-4-16(15)23)29-18(31)17-5-2-13(11-28-17)22(24,25)26/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1	UIRYVRRDGALEDP-FQEVSTJZSA-N	190730	US9181236, 34	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190730	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190730&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532114	316936019							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341433	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1sc(cc1Cl)-c1cncnc1	InChI=1S/C17H19ClN4O2S2/c1-16(9-26(23,24)17(15(19)22-16)4-2-3-5-17)14-12(18)6-13(25-14)11-7-20-10-21-8-11/h6-8,10H,2-5,9H2,1H3,(H2,19,22)/t16-/m0/s1	OKGIIMYABZFCGE-INIZCTEOSA-N	190743	US9181236, 43	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190743	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190743&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532171	316936029							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341434	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C20H21ClN4O2S2/c1-19(12-29(26,27)20(18(23)25-19)5-3-2-4-6-20)17-15(21)8-16(28-17)14-7-13(9-22)10-24-11-14/h7-8,10-11H,2-6,12H2,1H3,(H2,23,25)/t19-/m0/s1	LFYVWDBBKHUQRB-IBGZPJMESA-N	190747	US9181236, 46	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190747&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419831	316936033							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341435	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C22H23ClN4O3S2/c1-21(12-32(28,29)22(20(24)26-21)8-3-2-4-9-22)18-16(23)11-17(31-18)14-6-5-7-15(10-14)19-27-25-13-30-19/h5-7,10-11,13H,2-4,8-9,12H2,1H3,(H2,24,26)/t21-/m0/s1	FMPWXIMFOHUBCH-NRFANRHFSA-N	190749	US9181236, 47a	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190749	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190749&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532225	316936035							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341436	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)C#N	InChI=1S/C20H20ClN3O3S2/c1-19(12-29(25,26)20(18(23)24-19)5-7-27-8-6-20)17-15(21)10-16(28-17)14-4-2-3-13(9-14)11-22/h2-4,9-10H,5-8,12H2,1H3,(H2,23,24)/t19-/m0/s1	OWXWGPFRXDZKJL-IBGZPJMESA-N	190751	US9181236, 49	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190751&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419863	316936037							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341437	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C19H19ClN4O3S2/c1-18(11-29(25,26)19(17(22)24-18)2-4-27-5-3-19)16-14(20)7-15(28-16)13-6-12(8-21)9-23-10-13/h6-7,9-10H,2-5,11H2,1H3,(H2,22,24)/t18-/m0/s1	BKRFCIMYFIGWPL-SFHVURJKSA-N	190752	US9181236, 50	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190752&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532227	316936038							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341438	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)C(F)(F)F	InChI=1S/C20H20ClF3N2O3S2/c1-18(11-31(27,28)19(17(25)26-18)5-7-29-8-6-19)16-14(21)10-15(30-16)12-3-2-4-13(9-12)20(22,23)24/h2-4,9-10H,5-8,11H2,1H3,(H2,25,26)/t18-/m0/s1	DNHZFFCUHXIYBV-SFHVURJKSA-N	190754	US9181236, 52	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190754&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532285	316936040							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341439	C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C(F)(F)F	InChI=1S/C19H19ClF3N3O3S2/c1-17(10-31(27,28)18(16(24)26-17)2-4-29-5-3-18)15-13(20)7-14(30-15)11-6-12(9-25-8-11)19(21,22)23/h6-9H,2-5,10H2,1H3,(H2,24,26)/t17-/m0/s1	QNCLBVGRWYZFIY-KRWDZBQOSA-N	190756	US9181236, 54	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190756&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419901	316936042							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341440	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C20H19ClN4O3S2/c1-19(10-30(26,27)20(6-3-7-20)18(22)24-19)16-14(21)9-15(29-16)12-4-2-5-13(8-12)17-25-23-11-28-17/h2,4-5,8-9,11H,3,6-7,10H2,1H3,(H2,22,24)/t19-/m0/s1	WDDKHIMVXTWBGB-IBGZPJMESA-N	190765	US9181236, 61a	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190765&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419893	316936051							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341441	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C21H20F4N4O4S/c1-19(11-34(31,32)20(18(26)29-19)6-7-33-10-20)14-8-13(3-4-15(14)22)28-17(30)16-5-2-12(9-27-16)21(23,24)25/h2-5,8-9H,6-7,10-11H2,1H3,(H2,26,29)(H,28,30)/t19-,20-/m0/s1	RPIUMYMKUDIWNE-PMACEKPBSA-N	190770	US9181236, 62d	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190770&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419923	316936056							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341442	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1ccnc(c1)-c1ccoc1	InChI=1S/C21H20ClN3O4S2/c1-20(12-31(26,27)21(19(23)25-20)4-7-29-11-21)18-15(22)9-17(30-18)13-2-5-24-16(8-13)14-3-6-28-10-14/h2-3,5-6,8-10H,4,7,11-12H2,1H3,(H2,23,25)/t20-,21-/m0/s1	VDMXQZGFUSCMMR-SFTDATJTSA-N	190776	US9181236, 62j	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190776&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419921	316936062							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341443	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1	InChI=1S/C20H22FN5O5S/c1-19(11-32(28,29)20(18(22)26-19)5-6-31-10-20)13-7-12(3-4-14(13)21)25-17(27)15-8-24-16(30-2)9-23-15/h3-4,7-9H,5-6,10-11H2,1-2H3,(H2,22,26)(H,25,27)/t19-,20+/m0/s1	DRLLKMFQLBDKBH-VQTJNVASSA-N	190781	US9181236, 63	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190781&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419843	316936067							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341444	CC1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C18H17ClN4O3S2/c1-17(10-28(24,25)18(16(21)23-17)2-3-26-9-18)15-13(19)5-14(27-15)12-4-11(6-20)7-22-8-12/h4-5,7-8H,2-3,9-10H2,1H3,(H2,21,23)/t17?,18-/m1/s1	AGTITCAYQXIUEM-QRWMCTBCSA-N	190786	US9181236, 63e	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190786&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419891	316936072							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341445	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C20H19ClN4O4S2/c1-19(10-31(26,27)20(18(22)24-19)5-6-28-9-20)16-14(21)8-15(30-16)12-3-2-4-13(7-12)17-25-23-11-29-17/h2-4,7-8,11H,5-6,9-10H2,1H3,(H2,22,24)/t19-,20+/m0/s1	HWLPUVPUYORSNI-VQTJNVASSA-N	190788	US9181236, 63g	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190788&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419935	316936074							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341446	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)[N+]#[C-]	InChI=1S/C17H15ClN4O2S2/c1-16(9-26(23,24)17(3-4-17)15(19)22-16)14-12(18)6-13(25-14)10-5-11(20-2)8-21-7-10/h5-8H,3-4,9H2,1H3,(H2,19,22)/t16-/m0/s1	QPDBFNARPOLNRB-INIZCTEOSA-N	190797	US9181236, 65	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190797	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190797&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121494142	316936083							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341447	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C19H17ClN4O3S2/c1-18(9-29(25,26)19(5-6-19)17(21)23-18)15-13(20)8-14(28-15)11-3-2-4-12(7-11)16-24-22-10-27-16/h2-4,7-8,10H,5-6,9H2,1H3,(H2,21,23)/t18-/m0/s1	AIIRELZSHSFIJG-SFHVURJKSA-N	190798	US9181236, 65a	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190798&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419864	316936084							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341448	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCC2)C(=N)N1	InChI=1S/C20H22FN5O4S/c1-19(11-31(28,29)20(6-3-7-20)18(22)26-19)13-8-12(4-5-14(13)21)25-17(27)15-9-24-16(30-2)10-23-15/h4-5,8-10H,3,6-7,11H2,1-2H3,(H2,22,26)(H,25,27)/t19-/m0/s1	SUQOBLVVRQPVTI-IBGZPJMESA-N	190703	US9181236, 7	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190703	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190703&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71531972	316935992							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341449	C[C@]1(CS(=O)(=O)C2(CCC(O)C2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H22F2N4O4S/c1-20(11-32(30,31)21(19(24)27-20)7-6-14(28)9-21)15-8-13(3-4-16(15)23)26-18(29)17-5-2-12(22)10-25-17/h2-5,8,10,14,28H,6-7,9,11H2,1H3,(H2,24,27)(H,26,29)/t14?,20-,21?/m0/s1	PAJSDOHDTCSASR-NAXCRDPKSA-N	190809	US9181236, 76a (isomeric sample 1)::US9181236, 76b (isomeric sample 2)	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190809&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419860	316936087							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341450	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)C#CC1(CCCC1)c1ccccc1	InChI=1S/C25H27ClN2O2S2/c1-23(17-32(29,30)25(13-7-14-25)22(27)28-23)21-20(26)16-19(31-21)10-15-24(11-5-6-12-24)18-8-3-2-4-9-18/h2-4,8-9,16H,5-7,11-14,17H2,1H3,(H2,27,28)/t23-/m0/s1	JPZGRONGKIIGJT-QHCPKHFHSA-N	190811	US9181236, 77	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190811&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532435	316936088							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341451	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)C#CC1CCCC1	InChI=1S/C19H23ClN2O2S2/c1-18(12-26(23,24)19(9-4-10-19)17(21)22-18)16-15(20)11-14(25-16)8-7-13-5-2-3-6-13/h11,13H,2-6,9-10,12H2,1H3,(H2,21,22)/t18-/m0/s1	REAMUSFVFQVUST-SFHVURJKSA-N	190813	US9181236, 77b	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190813&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532488	316936090							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341452	C[C@]1(CS(=O)(=O)C2(CC2)C(=N)N1)c1sc(cc1Cl)C(=O)Nc1cccc(F)n1	InChI=1S/C17H16ClFN4O3S2/c1-16(8-28(25,26)17(5-6-17)15(20)23-16)13-9(18)7-10(27-13)14(24)22-12-4-2-3-11(19)21-12/h2-4,7H,5-6,8H2,1H3,(H2,20,23)(H,21,22,24)/t16-/m0/s1	UZEFHGYLBSEYOQ-INIZCTEOSA-N	190820	US9181236, 79c	Beta-secretase 2		<50						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190820	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190820&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419869	316936097							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341453	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)[N+]#[C-])ccc1F	InChI=1S/C21H20FN5O4S/c1-20(12-32(29,30)21(19(23)27-20)7-8-31-11-21)15-9-13(3-5-16(15)22)26-18(28)17-6-4-14(24-2)10-25-17/h3-6,9-10H,7-8,11-12H2,1H3,(H2,23,27)(H,26,28)/t20-,21-/m0/s1	USZRFRJIUFHLAK-SFTDATJTSA-N	190771	US9181236, 62e	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190771&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121494140	316936057							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341454	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CC2)C(=N)N1	InChI=1S/C19H20FN5O4S/c1-18(10-30(27,28)19(5-6-19)17(21)25-18)12-7-11(3-4-13(12)20)24-16(26)14-8-23-15(29-2)9-22-14/h3-4,7-9H,5-6,10H2,1-2H3,(H2,21,25)(H,24,26)/t18-/m0/s1	PHDUENDORNBRHI-SFHVURJKSA-N	190698	US9181236, 2	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190698	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190698&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71531968	316935987							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341455	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCC2)C(=N)N1	InChI=1S/C21H23FN4O4S/c1-20(12-31(28,29)21(8-3-9-21)19(23)26-20)15-10-13(4-6-16(15)22)25-18(27)17-7-5-14(30-2)11-24-17/h4-7,10-11H,3,8-9,12H2,1-2H3,(H2,23,26)(H,25,27)/t20-/m0/s1	OZYSRAOIIBLDKF-FQEVSTJZSA-N	190706	US9181236, 10	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190706	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190706&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419852	316935995							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341456	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)[N+]#[C-])ccc1F	InChI=1S/C21H20FN5O3S/c1-20(12-31(29,30)21(8-3-9-21)19(23)27-20)15-10-13(4-6-16(15)22)26-18(28)17-7-5-14(24-2)11-25-17/h4-7,10-11H,3,8-9,12H2,1H3,(H2,23,27)(H,26,28)/t20-/m0/s1	YVSTWCVYZLMQQU-FQEVSTJZSA-N	190707	US9181236, 11	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190707	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190707&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121494137	316935996							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341457	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2cnc(cn2)C(F)(F)F)ccc1F	InChI=1S/C21H21F4N5O3S/c1-19(11-34(32,33)20(18(26)30-19)6-2-3-7-20)13-8-12(4-5-14(13)22)29-17(31)15-9-28-16(10-27-15)21(23,24)25/h4-5,8-10H,2-3,6-7,11H2,1H3,(H2,26,30)(H,29,31)/t19-/m0/s1	CWADWULNGVXIKU-IBGZPJMESA-N	190712	US9181236, 16	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190712&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532015	316936001							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341458	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2cn3ncsc3n2)ccc1F	InChI=1S/C20H21FN6O3S2/c1-19(10-32(29,30)20(17(22)26-19)6-2-3-7-20)13-8-12(4-5-14(13)21)24-16(28)15-9-27-18(25-15)31-11-23-27/h4-5,8-9,11H,2-3,6-7,10H2,1H3,(H2,22,26)(H,24,28)/t19-/m0/s1	WUVCDLWMUXYNAJ-IBGZPJMESA-N	190715	US9181236, 19	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190715	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190715&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532017	316936004							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341459	C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2cn3ccsc3n2)ccc1F	InChI=1S/C21H22FN5O3S2/c1-20(12-32(29,30)21(18(23)26-20)6-2-3-7-21)14-10-13(4-5-15(14)22)24-17(28)16-11-27-8-9-31-19(27)25-16/h4-5,8-11H,2-3,6-7,12H2,1H3,(H2,23,26)(H,24,28)/t20-/m0/s1	IORNJWFILWBCCO-FQEVSTJZSA-N	190716	US9181236, 20	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190716	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190716&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419820	316936005							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341460	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H24ClFN4O3S/c1-21(13-32(30,31)22(20(25)28-21)9-3-2-4-10-22)16-11-15(6-7-17(16)24)27-19(29)18-8-5-14(23)12-26-18/h5-8,11-12H,2-4,9-10,13H2,1H3,(H2,25,28)(H,27,29)/t21-/m0/s1	QTKARDGAUMDUCL-NRFANRHFSA-N	190720	US9181236, 24	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190720&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532069	316936009							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341461	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCCCC2)C(=N)N1	InChI=1S/C23H27FN4O4S/c1-22(14-33(30,31)23(21(25)28-22)10-4-3-5-11-23)17-12-15(6-8-18(17)24)27-20(29)19-9-7-16(32-2)13-26-19/h6-9,12-13H,3-5,10-11,14H2,1-2H3,(H2,25,28)(H,27,29)/t22-/m0/s1	YNOFIMGNERACEK-QFIPXVFZSA-N	190722	US9181236, 26	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190722	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190722&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532070	316936011							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341462	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C23H24FN5O3S/c1-22(14-33(31,32)23(21(26)29-22)9-3-2-4-10-23)17-11-16(6-7-18(17)24)28-20(30)19-8-5-15(12-25)13-27-19/h5-8,11,13H,2-4,9-10,14H2,1H3,(H2,26,29)(H,28,30)/t22-/m0/s1	WADSREMULXRZPV-QFIPXVFZSA-N	190724	US9181236, 28	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190724	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190724&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532072	316936013							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341463	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCOCC2)C(=N)N1	InChI=1S/C22H25FN4O5S/c1-21(13-33(29,30)22(20(24)27-21)7-9-32-10-8-22)16-11-14(3-5-17(16)23)26-19(28)18-6-4-15(31-2)12-25-18/h3-6,11-12H,7-10,13H2,1-2H3,(H2,24,27)(H,26,28)/t21-/m0/s1	YSBNTVJQNMAZMP-NRFANRHFSA-N	190731	US9181236, 35	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419885	316936020							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341464	C[C@]1(CS(=O)(=O)C2(CCCCC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)C#N	InChI=1S/C21H22ClN3O2S2/c1-20(13-29(26,27)21(19(24)25-20)8-3-2-4-9-21)18-16(22)11-17(28-18)15-7-5-6-14(10-15)12-23/h5-7,10-11H,2-4,8-9,13H2,1H3,(H2,24,25)/t20-/m0/s1	LKRYRZKODNHHGO-FQEVSTJZSA-N	190746	US9181236, 45	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190746&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419832	316936032							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341465	COc1cc(cc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C2(CCOCC2)C(=N)N1)C#N	InChI=1S/C21H22ClN3O4S2/c1-20(12-31(26,27)21(19(24)25-20)3-5-29-6-4-21)18-16(22)10-17(30-18)14-7-13(11-23)8-15(9-14)28-2/h7-10H,3-6,12H2,1-2H3,(H2,24,25)/t20-/m0/s1	KQDDCVXWYJDOKS-FQEVSTJZSA-N	190759	US9181236, 57	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190759&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532287	316936045							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341466	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)[N+]#[C-]	InChI=1S/C18H17ClN4O2S2/c1-17(10-27(24,25)18(4-3-5-18)16(20)23-17)15-13(19)7-14(26-15)11-6-12(21-2)9-22-8-11/h6-9H,3-5,10H2,1H3,(H2,20,23)/t17-/m0/s1	QVOVMMNAVRTRCL-KRWDZBQOSA-N	190762	US9181236, 59	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190762	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190762&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121494138	316936048							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341467	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)[N+]#[C-]	InChI=1S/C19H18ClN3O2S2/c1-18(11-27(24,25)19(7-4-8-19)17(21)23-18)16-14(20)10-15(26-16)12-5-3-6-13(9-12)22-2/h3,5-6,9-10H,4,7-8,11H2,1H3,(H2,21,23)/t18-/m0/s1	NIKMCOHYQYSMPX-SFHVURJKSA-N	190764	US9181236, 61	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190764	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190764&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121494139	316936050							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341468	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1	InChI=1S/C20H22FN5O5S/c1-19(11-32(28,29)20(18(22)26-19)5-6-31-10-20)13-7-12(3-4-14(13)21)25-17(27)15-8-24-16(30-2)9-23-15/h3-4,7-9H,5-6,10-11H2,1-2H3,(H2,22,26)(H,25,27)/t19-,20-/m0/s1	DRLLKMFQLBDKBH-PMACEKPBSA-N	190766	US9181236, 62	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190766&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419837	316936052							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341469	CC1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C18H17ClN4O3S2/c1-17(10-28(24,25)18(16(21)23-17)2-3-26-9-18)15-13(19)5-14(27-15)12-4-11(6-20)7-22-8-12/h4-5,7-8H,2-3,9-10H2,1H3,(H2,21,23)/t17?,18-/m0/s1	AGTITCAYQXIUEM-ZVAWYAOSSA-N	190772	US9181236, 62f	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190772	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190772&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419911	316936058							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341470	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1ccnc(c1)-c1ccccc1	InChI=1S/C23H22ClN3O3S2/c1-22(14-32(28,29)23(21(25)27-22)8-10-30-13-23)20-17(24)12-19(31-20)16-7-9-26-18(11-16)15-5-3-2-4-6-15/h2-7,9,11-12H,8,10,13-14H2,1H3,(H2,25,27)/t22-,23-/m0/s1	KBPPPKWKTMOHMZ-GOTSBHOMSA-N	190780	US9181236, 62n	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190780	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190780&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419924	316936066							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341471	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1	InChI=1S/C21H23FN4O5S/c1-20(12-32(28,29)21(19(23)26-20)7-8-31-11-21)15-9-13(3-5-16(15)22)25-18(27)17-6-4-14(30-2)10-24-17/h3-6,9-10H,7-8,11-12H2,1-2H3,(H2,23,26)(H,25,27)/t20-,21-/m0/s1	CBUFFWOZPOZOQD-SFTDATJTSA-N	190767	US9181236, 62a	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190767&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419926	316936053							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341472	C[C@]1(CS(=O)(=O)[C@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1ccnc(c1)-c1cccs1	InChI=1S/C21H20ClN3O3S3/c1-20(12-31(26,27)21(19(23)25-20)5-7-28-11-21)18-14(22)10-17(30-18)13-4-6-24-15(9-13)16-3-2-8-29-16/h2-4,6,8-10H,5,7,11-12H2,1H3,(H2,23,25)/t20-,21-/m0/s1	DVZMBUIUHKIWNE-SFTDATJTSA-N	190777	US9181236, 62k	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190777&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419917	316936063							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341473	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1ccnc(c1)-c1ccsc1	InChI=1S/C21H20ClN3O3S3/c1-20(12-31(26,27)21(19(23)25-20)4-6-28-11-21)18-15(22)9-17(30-18)13-2-5-24-16(8-13)14-3-7-29-10-14/h2-3,5,7-10H,4,6,11-12H2,1H3,(H2,23,25)/t20-,21+/m0/s1	AWAMUWVIPTUDIC-LEWJYISDSA-N	190795	US9181236, 63n	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190795	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190795&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419897	316936081							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341474	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1	InChI=1S/C21H23FN4O5S/c1-20(12-32(28,29)21(19(23)26-20)7-8-31-11-21)15-9-13(3-5-16(15)22)25-18(27)17-6-4-14(30-2)10-24-17/h3-6,9-10H,7-8,11-12H2,1-2H3,(H2,23,26)(H,25,27)/t20-,21+/m0/s1	CBUFFWOZPOZOQD-LEWJYISDSA-N	190782	US9181236, 63a	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190782&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419934	316936068							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341475	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)-c1ncco1	InChI=1S/C20H19ClN4O4S2/c1-19(11-31(26,27)20(18(22)25-19)2-4-28-10-20)16-14(21)7-15(30-16)12-6-13(9-23-8-12)17-24-3-5-29-17/h3,5-9H,2,4,10-11H2,1H3,(H2,22,25)/t19-,20+/m0/s1	UZFBWJUQLKQDLI-VQTJNVASSA-N	190789	US9181236, 63h	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190789&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419937	316936075							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341476	C[C@]1(CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)[N+]#[C-])ccc1F	InChI=1S/C21H20FN5O4S/c1-20(12-32(29,30)21(19(23)27-20)7-8-31-11-21)15-9-13(3-5-16(15)22)26-18(28)17-6-4-14(24-2)10-25-17/h3-6,9-10H,7-8,11-12H2,1H3,(H2,23,27)(H,26,28)/t20-,21+/m0/s1	USZRFRJIUFHLAK-LEWJYISDSA-N	190785	US9181236, 63d	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190785&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121494141	316936071							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341477	CC(C)(C)C#Cc1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C2(CCC2)C(=N)N1	InChI=1S/C18H23ClN2O2S2/c1-16(2,3)9-6-12-10-13(19)14(24-12)17(4)11-25(22,23)18(7-5-8-18)15(20)21-17/h10H,5,7-8,11H2,1-4H3,(H2,20,21)/t17-/m0/s1	HRICSMLGCLIGIL-KRWDZBQOSA-N	190812	US9181236, 77a	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190812&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532487	316936089							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341478	C[C@]1(CS(=O)(=O)C2(CCC2)C(=N)N1)c1sc(cc1Cl)C#CCc1cc(F)c(F)c(F)c1	InChI=1S/C21H18ClF3N2O2S2/c1-20(11-31(28,29)21(6-3-7-21)19(26)27-20)18-14(22)10-13(30-18)5-2-4-12-8-15(23)17(25)16(24)9-12/h8-10H,3-4,6-7,11H2,1H3,(H2,26,27)/t20-/m0/s1	GBJQQTZKCKUYBI-FQEVSTJZSA-N	190816	US9181236, 78	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190816&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71532491	316936093							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341479	COc1cccc(NC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C3(CC3)C(=N)N2)n1	InChI=1S/C18H19ClN4O4S2/c1-17(9-29(25,26)18(6-7-18)16(20)23-17)14-10(19)8-11(28-14)15(24)22-12-4-3-5-13(21-12)27-2/h3-5,8H,6-7,9H2,1-2H3,(H2,20,23)(H,21,22,24)/t17-/m0/s1	DCNKSPJFLQQQJH-KRWDZBQOSA-N	190818	US9181236, 79a	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190818&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419874	316936095							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341480	CCc1cccc(NC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C3(CC3)C(=N)N2)n1	InChI=1S/C19H21ClN4O3S2/c1-3-11-5-4-6-14(22-11)23-16(25)13-9-12(20)15(28-13)18(2)10-29(26,27)19(7-8-19)17(21)24-18/h4-6,9H,3,7-8,10H2,1-2H3,(H2,21,24)(H,22,23,25)/t18-/m0/s1	QSAWERYBYXJFPA-SFHVURJKSA-N	190817	US9181236, 79	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190817&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419877	316936094							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
341481	Cc1cccc(NC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C3(CC3)C(=N)N2)n1	InChI=1S/C18H19ClN4O3S2/c1-10-4-3-5-13(21-10)22-15(24)12-8-11(19)14(27-12)17(2)9-28(25,26)18(6-7-18)16(20)23-17/h3-5,8H,6-7,9H2,1-2H3,(H2,20,23)(H,21,22,24)/t17-/m0/s1	MYOKSGUEBFQLKZ-KRWDZBQOSA-N	190821	US9181236, 79d	Beta-secretase 2		<20						5	30.00 C	US Patent		10.7270/Q2NC5ZZB		aid1801855	US9181236	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190821&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89419870	316936098							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339316	COCC1(COC)C(=N)N[C@@](C)(CS1(=O)=O)c1sc(Br)cc1Cl	InChI=1S/C13H18BrClN2O4S2/c1-12(10-8(15)4-9(14)22-10)7-23(18,19)13(5-20-2,6-21-3)11(16)17-12/h4H,5-7H2,1-3H3,(H2,16,17)/t12-/m0/s1	UCLNBAQRRPLRQG-LBPRGKRZSA-N	259257	US9499502, Table A: Entry 89	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095241	350083954							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339367	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(Br)cs1	InChI=1S/C11H15BrN2O2S2/c1-10(2)9(13)14-11(3,6-18(10,15)16)8-4-7(12)5-17-8/h4-5H,6H2,1-3H3,(H2,13,14)/t11-/m0/s1	IXFWAWBNNZPJAJ-NSHDSACASA-N	259258	US9499502, Table A: Entry 92	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259258&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095059	350083955							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339368	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1F	InChI=1S/C19H17F5N2O2S/c1-17(14-7-6-13(20)9-15(14)21)10-29(27,28)18(2,16(25)26-17)11-4-3-5-12(8-11)19(22,23)24/h3-9H,10H2,1-2H3,(H2,25,26)/t17-,18-/m0/s1	DPSKZHWZWPCSEG-ROUUACIJSA-N	259218	US9499502, 32h-a	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095402	350083916							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339369	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(c1)C(F)(F)F)c1cc(ccc1F)[N+]([O-])=O	InChI=1S/C19H17F4N3O4S/c1-17(14-9-13(26(27)28)6-7-15(14)20)10-31(29,30)18(2,16(24)25-17)11-4-3-5-12(8-11)19(21,22)23/h3-9H,10H2,1-2H3,(H2,24,25)/t17-,18-/m0/s1	OKDPMVFWWHMBJV-ROUUACIJSA-N	259248	US9499502, Table A: Entry 66	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095137	350083946							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339370	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(c1)C(F)(F)F)c1cc(N)ccc1F	InChI=1S/C19H19F4N3O2S/c1-17(14-9-13(24)6-7-15(14)20)10-29(27,28)18(2,16(25)26-17)11-4-3-5-12(8-11)19(21,22)23/h3-9H,10,24H2,1-2H3,(H2,25,26)/t17-,18-/m0/s1	VOFOYONCBAPCFX-ROUUACIJSA-N	259249	US9499502, Table A: Entry 68	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259249&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095303	350083947							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339371	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cc(ccn1)C(F)(F)F)c1cc(N)ccc1F	InChI=1S/C18H18F4N4O2S/c1-16(12-8-11(23)3-4-13(12)19)9-29(27,28)17(2,15(24)26-16)14-7-10(5-6-25-14)18(20,21)22/h3-8H,9,23H2,1-2H3,(H2,24,26)/t16-,17-/m0/s1	DUABZLBQZWECTR-IRXDYDNUSA-N	259250	US9499502, Table A: Entry 72::US9499502, Table A: Entry 73	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095234	350083948							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339372	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cc(ccn1)C(F)(F)F)c1cc(N)ccc1F	InChI=1S/C18H18F4N4O2S/c1-16(12-8-11(23)3-4-13(12)19)9-29(27,28)17(2,15(24)26-16)14-7-10(5-6-25-14)18(20,21)22/h3-8H,9,23H2,1-2H3,(H2,24,26)/t16-,17-/m0/s1	DUABZLBQZWECTR-IRXDYDNUSA-N	259250	US9499502, Table A: Entry 72::US9499502, Table A: Entry 73	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095234	350083948							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339373	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccn1)c1cc(N)ccc1F	InChI=1S/C17H19FN4O2S/c1-16(12-9-11(19)6-7-13(12)18)10-25(23,24)17(2,15(20)22-16)14-5-3-4-8-21-14/h3-9H,10,19H2,1-2H3,(H2,20,22)/t16-,17-/m0/s1	SBGZFDSPMSADCQ-IRXDYDNUSA-N	259252	US9499502, Table A: Entry 76	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259252&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095252	350083949							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339374	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(Br)cc1Cl	InChI=1S/C11H14BrClN2O2S2/c1-10(2)9(14)15-11(3,5-19(10,16)17)8-6(13)4-7(12)18-8/h4H,5H2,1-3H3,(H2,14,15)/t11-/m0/s1	VHTOUKSPWCBSRV-NSHDSACASA-N	259253	US9499502, Table A: Entry 78	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562259	350083950							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
339375	C[C@]1(CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1)c1sc(Br)cc1F	InChI=1S/C12H13BrF4N2O2S2/c1-10(8-6(14)3-7(13)22-8)5-23(20,21)11(2,9(18)19-10)4-12(15,16)17/h3H,4-5H2,1-2H3,(H2,18,19)/t10-,11-/m0/s1	YAKLFPOGXMYXCU-QWRGUYRKSA-N	259254	US9499502, Table A: Entry 81	Beta-secretase 2		 4600						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095145	350083951							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354121	CN1C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H17F2N5O4S/c1-25-17(21)24-18(9-29-8-15(18)30(25,27)28)12-6-11(3-4-13(12)20)23-16(26)14-5-2-10(19)7-22-14/h2-7,15H,8-9H2,1H3,(H2,21,24)(H,23,26)/t15-,18-/m1/s1	FEUVBQUAABZEJQ-CRAIPNDOSA-N	199087	US9221839, 1	Beta-secretase 2		 1.9						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199087	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199087&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467927	318490063							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354122	CN1C(=N)N[C@@]2(COC[C@@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H17F2N5O4S/c1-25-17(21)24-18(9-29-8-15(18)30(25,27)28)12-6-11(3-4-13(12)20)23-16(26)14-5-2-10(19)7-22-14/h2-7,15H,8-9H2,1H3,(H2,21,24)(H,23,26)/t15-,18-/m0/s1	FEUVBQUAABZEJQ-YJBOKZPZSA-N	199089	US9221839, 1a	Beta-secretase 2		 491						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199089&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467928	318490064							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354123	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C19H20FN5O5S/c1-25-18(21)24-19(10-30-9-16(19)31(25,27)28)13-7-11(3-5-14(13)20)23-17(26)15-6-4-12(29-2)8-22-15/h3-8,16H,9-10H2,1-2H3,(H2,21,24)(H,23,26)/t16-,19-/m1/s1	DKOVCLRDSGGWRB-VQIMIIECSA-N	199093	US9221839, 3	Beta-secretase 2		 8.2						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199093&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467930	318490065							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354124	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]12COC[C@@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C19H20FN5O5S/c1-25-18(21)24-19(10-30-9-16(19)31(25,27)28)13-7-11(3-5-14(13)20)23-17(26)15-6-4-12(29-2)8-22-15/h3-8,16H,9-10H2,1-2H3,(H2,21,24)(H,23,26)/t16-,19-/m0/s1	DKOVCLRDSGGWRB-LPHOPBHVSA-N	199095	US9221839, 3a	Beta-secretase 2		 475.7						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199095&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467931	318490066							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354125	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C18H19FN6O5S/c1-25-17(20)24-18(9-30-8-14(18)31(25,27)28)11-5-10(3-4-12(11)19)23-16(26)13-6-22-15(29-2)7-21-13/h3-7,14H,8-9H2,1-2H3,(H2,20,24)(H,23,26)/t14-,18-/m1/s1	XPCOWTWHHNDBJU-RDTXWAMCSA-N	199097	US9221839, 4	Beta-secretase 2		 48.4						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199097&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71467932	318490067							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354126	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@@]12COC[C@@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C18H19FN6O5S/c1-25-17(20)24-18(9-30-8-14(18)31(25,27)28)11-5-10(3-4-12(11)19)23-16(26)13-6-22-15(29-2)7-21-13/h3-7,14H,8-9H2,1-2H3,(H2,20,24)(H,23,26)/t14-,18-/m0/s1	XPCOWTWHHNDBJU-KSSFIOAISA-N	199099	US9221839, 4a	Beta-secretase 2		 1509						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199099&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468017	318490068							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354127	CN1C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H17ClFN5O4S/c1-25-17(21)24-18(9-29-8-15(18)30(25,27)28)12-6-11(3-4-13(12)20)23-16(26)14-5-2-10(19)7-22-14/h2-7,15H,8-9H2,1H3,(H2,21,24)(H,23,26)/t15-,18-/m1/s1	UMTXXAYFIKSALN-CRAIPNDOSA-N	199101	US9221839, 5	Beta-secretase 2		 1.3						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199101&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66551243	318490069							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354129	CN1C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C19H17F4N5O4S/c1-28-17(24)27-18(9-32-8-15(18)33(28,30)31)12-6-11(3-4-13(12)20)26-16(29)14-5-2-10(7-25-14)19(21,22)23/h2-7,15H,8-9H2,1H3,(H2,24,27)(H,26,29)/t15-,18-/m1/s1	NWYYHVQOQPDKNW-CRAIPNDOSA-N	199105	US9221839, 6	Beta-secretase 2		 19.5						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199105	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199105&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468019	318490071							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354130	CN1C(=N)N[C@@]2(COC[C@@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C19H17F4N5O4S/c1-28-17(24)27-18(9-32-8-15(18)33(28,30)31)12-6-11(3-4-13(12)20)26-16(29)14-5-2-10(7-25-14)19(21,22)23/h2-7,15H,8-9H2,1H3,(H2,24,27)(H,26,29)/t15-,18-/m0/s1	NWYYHVQOQPDKNW-YJBOKZPZSA-N	199107	US9221839, 6a	Beta-secretase 2		 472.8						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199107&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468020	318490072							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354131	CN1C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F	InChI=1S/C18H17F3N6O4S/c1-27-17(22)26-18(8-31-7-14(18)32(27,29)30)10-4-9(2-3-11(10)19)25-16(28)13-6-23-12(5-24-13)15(20)21/h2-6,14-15H,7-8H2,1H3,(H2,22,26)(H,25,28)/t14-,18-/m1/s1	IQUBPELHSBAKON-RDTXWAMCSA-N	199109	US9221839, 6b	Beta-secretase 2		 17.4						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199109&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468021	318490073							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354132	CN1C(=N)N[C@@]2(COC[C@@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F	InChI=1S/C18H17F3N6O4S/c1-27-17(22)26-18(8-31-7-14(18)32(27,29)30)10-4-9(2-3-11(10)19)25-16(28)13-6-23-12(5-24-13)15(20)21/h2-6,14-15H,7-8H2,1H3,(H2,22,26)(H,25,28)/t14-,18-/m0/s1	IQUBPELHSBAKON-KSSFIOAISA-N	199111	US9221839, 6c	Beta-secretase 2		 857.5						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199111&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468127	318490074							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354133	CN1C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)(F)F)ccc1F	InChI=1S/C18H16F4N6O4S/c1-28-16(23)27-17(8-32-7-14(17)33(28,30)31)10-4-9(2-3-11(10)19)26-15(29)12-5-25-13(6-24-12)18(20,21)22/h2-6,14H,7-8H2,1H3,(H2,23,27)(H,26,29)/t14-,17-/m1/s1	XDAWJBFIMXHPID-RHSMWYFYSA-N	199113	US9221839, 6d	Beta-secretase 2		 55						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199113&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468128	318490075							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354134	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]23COC[C@H]2S(=O)(=O)N(C)C(=N)N3)c(F)c1	InChI=1S/C19H19F2N5O5S/c1-26-18(22)25-19(9-31-8-15(19)32(26,28)29)12-5-10(3-4-13(12)20)24-17(27)16-14(21)6-11(30-2)7-23-16/h3-7,15H,8-9H2,1-2H3,(H2,22,25)(H,24,27)/t15-,19-/m1/s1	LEHXYLCBOVXRTG-DNVCBOLYSA-N	199115	US9221839, 6e	Beta-secretase 2		 6.9						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199115&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468129	318490076							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354135	CN1C(=N)NC2(COCC2S1(=O)=O)c1ccccc1F	InChI=1S/C12H14FN3O3S/c1-16-11(14)15-12(8-4-2-3-5-9(8)13)7-19-6-10(12)20(16,17)18/h2-5,10H,6-7H2,1H3,(H2,14,15)	JEUWZBSZTAEEME-UHFFFAOYSA-N	199117	US9221839, 6f	Beta-secretase 2		 4204						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199117&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468130	318490077							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
354128	CN1C(=N)N[C@@]2(COC[C@@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H17ClFN5O4S/c1-25-17(21)24-18(9-29-8-15(18)30(25,27)28)12-6-11(3-4-13(12)20)23-16(26)14-5-2-10(19)7-22-14/h2-7,15H,8-9H2,1H3,(H2,21,24)(H,23,26)/t15-,18-/m0/s1	UMTXXAYFIKSALN-YJBOKZPZSA-N	199103	US9221839, 5a	Beta-secretase 2		 55.2						5	30.00 C	US Patent		10.7270/Q27D2SZR		aid1802071	US9221839	Cumming, JN; Gilbert, EJ; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=199103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=199103&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468018	318490070							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359390	CC(C)CCNc1ccc(F)c(c1)[C@]1(C)COCC(N)=N1	InChI=1S/C16H24FN3O/c1-11(2)6-7-19-12-4-5-14(17)13(8-12)16(3)10-21-9-15(18)20-16/h4-5,8,11,19H,6-7,9-10H2,1-3H3,(H2,18,20)/t16-/m0/s1	VGSIYGKAKNKCHH-INIZCTEOSA-N	202597	US9242943, 6	Beta-secretase 2			 605							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202597	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202597&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520044	319495649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359391	C[C@]1(COCC(N)=N1)c1cc(NCCC(F)(F)F)ccc1F	InChI=1S/C14H17F4N3O/c1-13(8-22-7-12(19)21-13)10-6-9(2-3-11(10)15)20-5-4-14(16,17)18/h2-3,6,20H,4-5,7-8H2,1H3,(H2,19,21)/t13-/m0/s1	YHBCCGYRJHZRIT-ZDUSSCGKSA-N	202603	US9242943, 12	Beta-secretase 2			 2900							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202603&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520043	319495653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359392	C[C@]1(COCC(N)=N1)c1cc(NC2CCC2)ccc1F	InChI=1S/C15H20FN3O/c1-15(9-20-8-14(17)19-15)12-7-11(5-6-13(12)16)18-10-3-2-4-10/h5-7,10,18H,2-4,8-9H2,1H3,(H2,17,19)/t15-/m0/s1	KKLMFSIUUFHDAW-HNNXBMFYSA-N	202605	US9242943, 14	Beta-secretase 2			 1170							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202605&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520133	319495655							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359393	C[C@]1(COCC(N)=N1)c1cc(NC2CCCC2)ccc1F	InChI=1S/C16H22FN3O/c1-16(10-21-9-15(18)20-16)13-8-12(6-7-14(13)17)19-11-4-2-3-5-11/h6-8,11,19H,2-5,9-10H2,1H3,(H2,18,20)/t16-/m0/s1	SNBVGRNXFMZUNZ-INIZCTEOSA-N	202606	US9242943, 15	Beta-secretase 2			 170							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202606	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202606&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520131	319495656							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359394	C[C@]1(COCC(N)=N1)c1cc(NC2CCOC2)ccc1F	InChI=1S/C15H20FN3O2/c1-15(9-21-8-14(17)19-15)12-6-10(2-3-13(12)16)18-11-4-5-20-7-11/h2-3,6,11,18H,4-5,7-9H2,1H3,(H2,17,19)/t11?,15-/m0/s1	IUECETKEUARTFS-MHTVFEQDSA-N	202609	US9242943, 18	Beta-secretase 2			 3391							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202609&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520135	319495657							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359395	C[C@]1(COCC(N)=N1)c1cc(N[C@H]2CCC[C@@H]2O)ccc1F	InChI=1S/C16H22FN3O2/c1-16(9-22-8-15(18)20-16)11-7-10(5-6-12(11)17)19-13-3-2-4-14(13)21/h5-7,13-14,19,21H,2-4,8-9H2,1H3,(H2,18,20)/t13-,14-,16-/m0/s1	RWCZTUDBYGQJTK-DZKIICNBSA-N	202610	US9242943, 19	Beta-secretase 2			 3419							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202610&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57519957	319495658							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359396	C[C@]1(COCC(N)=N1)c1cc(N[C@H]2CCC[C@H]2O)ccc1F	InChI=1S/C16H22FN3O2/c1-16(9-22-8-15(18)20-16)11-7-10(5-6-12(11)17)19-13-3-2-4-14(13)21/h5-7,13-14,19,21H,2-4,8-9H2,1H3,(H2,18,20)/t13-,14+,16-/m0/s1	RWCZTUDBYGQJTK-LZWOXQAQSA-N	202611	US9242943, 20	Beta-secretase 2			 2270							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202611&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57519956	319495659							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359397	C[C@]1(COCC(N)=N1)c1cc(NCC2CC2)ccc1F	InChI=1S/C15H20FN3O/c1-15(9-20-8-14(17)19-15)12-6-11(4-5-13(12)16)18-7-10-2-3-10/h4-6,10,18H,2-3,7-9H2,1H3,(H2,17,19)/t15-/m0/s1	ORNNHNZPHILLPY-HNNXBMFYSA-N	202612	US9242943, 21	Beta-secretase 2			 279							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202612&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68108170	319495660							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359398	C[C@]1(COCC(N)=N1)c1cc(NC[C@H]2CCCO2)ccc1F	InChI=1S/C16H22FN3O2/c1-16(10-21-9-15(18)20-16)13-7-11(4-5-14(13)17)19-8-12-3-2-6-22-12/h4-5,7,12,19H,2-3,6,8-10H2,1H3,(H2,18,20)/t12-,16+/m1/s1	FSAJCWVALVMAKW-WBMJQRKESA-N	202613	US9242943, 22	Beta-secretase 2			 2430							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202613&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68107253	319495661							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359399	CC(C)C(Nc1ccc(F)c(c1)[C@]1(C)COCC(N)=N1)c1ccc(Cl)cn1	InChI=1S/C20H24ClFN4O/c1-12(2)19(17-7-4-13(21)9-24-17)25-14-5-6-16(22)15(8-14)20(3)11-27-10-18(23)26-20/h4-9,12,19,25H,10-11H2,1-3H3,(H2,23,26)/t19?,20-/m0/s1	XUDAQSPLHDYMTP-ANYOKISRSA-N	202614	US9242943, 23	Beta-secretase 2			 1662							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202614&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520206	319495662							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359400	CC1(COCC(N)=N1)c1cccc(Nc2cccc3cc(Cl)cnc23)c1	InChI=1S/C20H19ClN4O/c1-20(12-26-11-18(22)25-20)14-5-3-6-16(9-14)24-17-7-2-4-13-8-15(21)10-23-19(13)17/h2-10,24H,11-12H2,1H3,(H2,22,25)	MISZEAYFRRVHET-UHFFFAOYSA-N	202615	US9242943, 24	Beta-secretase 2			 18							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202615	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202615&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	5T8	5F00	57520407	319495663							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359401	C[C@]1(COCC(N)=N1)c1cc(Nc2cccc3cc(Cl)cnc23)ccc1F	InChI=1S/C20H18ClFN4O/c1-20(11-27-10-18(23)26-20)15-8-14(5-6-16(15)22)25-17-4-2-3-12-7-13(21)9-24-19(12)17/h2-9,25H,10-11H2,1H3,(H2,23,26)/t20-/m0/s1	QIANIVYIOVZEHV-FQEVSTJZSA-N	202617	US9242943, 26	Beta-secretase 2			 77							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202617	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202617&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57412091	319495664							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359402	C[C@]1(COCC(N)=N1)c1cc(Nc2cc(Cl)cc3cc(Cl)cnc23)ccc1F	InChI=1S/C20H17Cl2FN4O/c1-20(10-28-9-18(24)27-20)15-7-14(2-3-16(15)23)26-17-6-12(21)4-11-5-13(22)8-25-19(11)17/h2-8,26H,9-10H2,1H3,(H2,24,27)/t20-/m0/s1	LBDVFEXBWOROJV-FQEVSTJZSA-N	202618	US9242943, 27	Beta-secretase 2			 558							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202618	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202618&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520209	319495665							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359403	C[C@]1(COCC(N)=N1)c1cc(Nc2cccc3cc(OC(F)F)cnc23)ccc1F	InChI=1S/C21H19F3N4O2/c1-21(11-29-10-18(25)28-21)15-8-13(5-6-16(15)22)27-17-4-2-3-12-7-14(30-20(23)24)9-26-19(12)17/h2-9,20,27H,10-11H2,1H3,(H2,25,28)/t21-/m0/s1	CHPYWNCYTLASBD-NRFANRHFSA-N	202620	US9242943, 29	Beta-secretase 2			 2296							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202620	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202620&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520305	319495667							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359404	C[C@]1(COCC(N)=N1)c1cc(Nc2ccon2)ccc1F	InChI=1S/C14H15FN4O2/c1-14(8-20-7-12(16)18-14)10-6-9(2-3-11(10)15)17-13-4-5-21-19-13/h2-6H,7-8H2,1H3,(H2,16,18)(H,17,19)/t14-/m0/s1	QRXTWNWAFMAMIP-AWEZNQCLSA-N	202624	US9242943, 33	Beta-secretase 2			 1210							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202624	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202624&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520134	319495671							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359405	Cn1nc(Nc2ccc(F)c(c2)[C@@]2(C)COCC(N)=N2)c2ccc(Cl)cc12	InChI=1S/C19H19ClFN5O/c1-19(10-27-9-17(22)24-19)14-8-12(4-6-15(14)21)23-18-13-5-3-11(20)7-16(13)26(2)25-18/h3-8H,9-10H2,1-2H3,(H2,22,24)(H,23,25)/t19-/m1/s1	TWQFDPFLUOXDSO-LJQANCHMSA-N	202625	US9242943, 34	Beta-secretase 2			 1481							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202625&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520208	319495672							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359406	C[C@@]1(COCC(N)=N1)c1cc(NC2CCc3cc(Cl)ccc23)ccc1F	InChI=1S/C20H21ClFN3O/c1-20(11-26-10-19(23)25-20)16-9-14(4-6-17(16)22)24-18-7-2-12-8-13(21)3-5-15(12)18/h3-6,8-9,18,24H,2,7,10-11H2,1H3,(H2,23,25)/t18?,20-/m1/s1	IVCFPJIINVIDFL-ROPPNANJSA-N	202626	US9242943, 35	Beta-secretase 2			 732							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202626&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520516	319495673							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359407	COc1cnc2c(Nc3cccc(c3)C3(C)COCC(N)=N3)cccc2c1	InChI=1S/C21H22N4O2/c1-21(13-27-12-19(22)25-21)15-6-4-7-16(10-15)24-18-8-3-5-14-9-17(26-2)11-23-20(14)18/h3-11,24H,12-13H2,1-2H3,(H2,22,25)	IGUZINVHWNCBIH-UHFFFAOYSA-N	202628	US9242943, 37	Beta-secretase 2			 120							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202628&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520409	319495675							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359408	C[C@]1(COCC(N)=N1)c1cc(NC2CCc3cc(Cl)cnc23)ccc1F	InChI=1S/C19H20ClFN4O/c1-19(10-26-9-17(22)25-19)14-7-13(3-4-15(14)21)24-16-5-2-11-6-12(20)8-23-18(11)16/h3-4,6-8,16,24H,2,5,9-10H2,1H3,(H2,22,25)/t16?,19-/m0/s1	JQWLQZLXFFDJIN-CVMIBEPCSA-N	202631	US9242943, 40	Beta-secretase 2			 1097							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202631	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202631&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520619	319495677							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359409	C[C@]1(COCC(N)=N1)c1cc(Nc2ccccc2OCC(F)F)ccc1F	InChI=1S/C19H20F3N3O2/c1-19(11-26-10-18(23)25-19)13-8-12(6-7-14(13)20)24-15-4-2-3-5-16(15)27-9-17(21)22/h2-8,17,24H,9-11H2,1H3,(H2,23,25)/t19-/m0/s1	QNHDYGNNUMCCRR-IBGZPJMESA-N	202632	US9242943, 41	Beta-secretase 2			 10							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202632&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520207	319495678							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
359410	CC1(COCC(N)=N1)c1cccc(Nc2cccc3oc(nc23)C2CC2)c1	InChI=1S/C21H22N4O2/c1-21(12-26-11-18(22)25-21)14-4-2-5-15(10-14)23-16-6-3-7-17-19(16)24-20(27-17)13-8-9-13/h2-7,10,13,23H,8-9,11-12H2,1H3,(H2,22,25)	QPTMIQYCEQIDKW-UHFFFAOYSA-N	202637	US9242943, 46	Beta-secretase 2			 300							US Patent		10.7270/Q2833QV5		aid1802155	US9242943	Andreini, M; Gabellieri, E; Guba, W; Hilpert, H; Mayweg, AV; Narquizian, R; Power, E; Travagli, M; Woltering, T; Wostl, W; Mauser, H	Siena Biotech SpA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=202637	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=202637&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57520310	319495682							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
366798	C[C@H]1SC(N)=N[C@]2(CO[C@@H](CF)C[C@@H]12)c1ccc(F)cc1F	InChI=1S/C15H17F3N2OS/c1-8-12-5-10(6-16)21-7-15(12,20-14(19)22-8)11-3-2-9(17)4-13(11)18/h2-4,8,10,12H,5-7H2,1H3,(H2,19,20)/t8-,10-,12+,15-/m1/s1	LRUAFSXDUNPHJT-WABIZIGASA-N	207625	US9260455, 1	Beta-secretase 2			 1560					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802267	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=207625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=207625&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73507166	322058194							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
366799	COC[C@H]1C[C@H]2[C@@H](C)SC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C16H20F2N2O2S/c1-9-13-6-11(7-21-2)22-8-16(13,20-15(19)23-9)12-4-3-10(17)5-14(12)18/h3-5,9,11,13H,6-8H2,1-2H3,(H2,19,20)/t9-,11-,13+,16-/m1/s1	VWZBYKQRKVQAQK-QBTOZTBISA-N	50081643	CHEMBL3422240::US9260455, 2	Beta-secretase 2			 2310					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802267	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081643&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73507168	313074384		CHEMBL3422240					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
366800	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C14H16F2N2OS/c1-8-4-9-6-20-13(17)18-14(9,7-19-8)11-3-2-10(15)5-12(11)16/h2-3,5,8-9H,4,6-7H2,1H3,(H2,17,18)/t8-,9-,14-/m0/s1	OLZWOORXDWFBII-FZNYLWTLSA-N	50078349	CHEMBL3414707::US9260455, 3	Beta-secretase 2			 1140					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802267	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078349	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078349&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73507167	313073631		CHEMBL3414707					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
366801	NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C(F)F)c1ccc(F)cc1F	InChI=1S/C14H14F4N2OS/c15-8-1-2-9(10(16)4-8)14-6-21-11(12(17)18)3-7(14)5-22-13(19)20-14/h1-2,4,7,11-12H,3,5-6H2,(H2,19,20)/t7-,11+,14-/m0/s1	JPLGMHYUAWBTII-OXSLBIJZSA-N	50078320	CHEMBL3414700::US9260455, 4	Beta-secretase 2			 2140					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802267	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078320&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73507165	103970916		CHEMBL3414700				ZINC06176176	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
366802	CCOC[C@H]1C[C@H]2[C@@H](C)SC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H22F2N2O2S/c1-3-22-8-12-7-14-10(2)24-16(20)21-17(14,9-23-12)13-5-4-11(18)6-15(13)19/h4-6,10,12,14H,3,7-9H2,1-2H3,(H2,20,21)/t10-,12-,14+,17-/m1/s1	PSZBVAJZXDPBHP-SXRDFINZSA-N	207626	US9260455, 5	Beta-secretase 2			 274					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802267	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=207626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=207626&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73507169	322058195							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
366803	CC(C)OC[C@H]1C[C@H]2[C@@H](C)SC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C18H24F2N2O2S/c1-10(2)23-8-13-7-15-11(3)25-17(21)22-18(15,9-24-13)14-5-4-12(19)6-16(14)20/h4-6,10-11,13,15H,7-9H2,1-3H3,(H2,21,22)/t11-,13-,15+,18-/m1/s1	WNSIJZXQJTZAPQ-JPHJHBEYSA-N	207627	US9260455, 6	Beta-secretase 2			 5080					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802267	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=207627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=207627&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73507383	322058196							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
366804	COC[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C15H18F2N2O2S/c1-20-6-11-4-9-7-22-14(18)19-15(9,8-21-11)12-3-2-10(16)5-13(12)17/h2-3,5,9,11H,4,6-8H2,1H3,(H2,18,19)/t9-,11+,15-/m0/s1	AVYXEHSYNNACNZ-ISOBSLSZSA-N	50078324	CHEMBL3414708::US9260455, 8	Beta-secretase 2			 1630					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802267	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078324&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73507384	313073630		CHEMBL3414708					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375819	CC1(COCC(N)=N1)c1cccc(Nc2nsc3cc(Br)ccc23)c1	InChI=1S/C18H17BrN4OS/c1-18(10-24-9-16(20)22-18)11-3-2-4-13(7-11)21-17-14-6-5-12(19)8-15(14)25-23-17/h2-8H,9-10H2,1H3,(H2,20,22)(H,21,23)	IRNHZHZGEZSMNC-UHFFFAOYSA-N	213710	US9284284, 1	Beta-secretase 2			 1900					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549811	329729228							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375820	Cn1nc(Nc2cccc(c2)C2(C)COCC(N)=N2)c2ccc(Br)cc12	InChI=1S/C19H20BrN5O/c1-19(11-26-10-17(21)23-19)12-4-3-5-14(8-12)22-18-15-7-6-13(20)9-16(15)25(2)24-18/h3-9H,10-11H2,1-2H3,(H2,21,23)(H,22,24)	ULLQWIFBVSWJHE-UHFFFAOYSA-N	213711	US9284284, 2	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213711	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213711&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549812	329729229							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375821	CC1(COCC(N)=N1)c1cccc(Nc2noc3ccccc23)c1	InChI=1S/C18H18N4O2/c1-18(11-23-10-16(19)21-18)12-5-4-6-13(9-12)20-17-14-7-2-3-8-15(14)24-22-17/h2-9H,10-11H2,1H3,(H2,19,21)(H,20,22)	PHZPZMNFNUMKEH-UHFFFAOYSA-N	213712	US9284284, 3	Beta-secretase 2			 3200					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213712&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549813	329729230							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375822	CC1(COCC(N)=N1)c1cc(NCc2ccco2)ccc1F	InChI=1S/C16H18FN3O2/c1-16(10-21-9-15(18)20-16)13-7-11(4-5-14(13)17)19-8-12-3-2-6-22-12/h2-7,19H,8-10H2,1H3,(H2,18,20)	JLUMEQSFNWWCPP-UHFFFAOYSA-N	213713	US9284284, 4	Beta-secretase 2			 2400					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213713&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549814	329729231							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375823	NC1=NC(CF)(COC1)c1cc(NCc2ccc(Br)cc2Cl)ccc1F	InChI=1S/C18H17BrClF2N3O/c19-12-2-1-11(15(20)5-12)7-24-13-3-4-16(22)14(6-13)18(9-21)10-26-8-17(23)25-18/h1-6,24H,7-10H2,(H2,23,25)	WMBXACSSTBZEHH-UHFFFAOYSA-N	213714	US9284284, 5	Beta-secretase 2			 5300					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213714	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213714&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549815	329729232							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375824	NC1=NC(COC1)(C(F)F)c1cc(NCc2cc(Br)co2)ccc1F	InChI=1S/C16H15BrF3N3O2/c17-9-3-11(25-6-9)5-22-10-1-2-13(18)12(4-10)16(15(19)20)8-24-7-14(21)23-16/h1-4,6,15,22H,5,7-8H2,(H2,21,23)	CDLGKJBMNRHHIV-UHFFFAOYSA-N	213715	US9284284, 6	Beta-secretase 2			 8300					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213715	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213715&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549950	329729233							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375825	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2ncnc3cc(Cl)cnc23)ccc1F	InChI=1S/C18H14ClF3N6O/c19-9-3-13-15(24-5-9)16(26-8-25-13)27-10-1-2-12(20)11(4-10)18(17(21)22)7-29-6-14(23)28-18/h1-5,8,17H,6-7H2,(H2,23,28)(H,25,26,27)/t18-/m0/s1	UMASOBCVAWOXNZ-SFHVURJKSA-N	213716	US9284284, 7	Beta-secretase 2			 32					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213716	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213716&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549951	329729234							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375826	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2nccc3cc(Br)cnc23)ccc1F	InChI=1S/C19H15BrF3N5O/c20-11-5-10-3-4-25-17(16(10)26-7-11)27-12-1-2-14(21)13(6-12)19(18(22)23)9-29-8-15(24)28-19/h1-7,18H,8-9H2,(H2,24,28)(H,25,27)/t19-/m0/s1	PZBFITCCFKBBLL-IBGZPJMESA-N	213717	US9284284, 8	Beta-secretase 2			 11					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213717&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549953	329729235							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375827	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2nccc3cc(cnc23)C#N)ccc1F	InChI=1S/C20H15F3N6O/c21-15-2-1-13(6-14(15)20(19(22)23)10-30-9-16(25)29-20)28-18-17-12(3-4-26-18)5-11(7-24)8-27-17/h1-6,8,19H,9-10H2,(H2,25,29)(H,26,28)/t20-/m0/s1	AYBCGPRPLJRSKE-FQEVSTJZSA-N	213718	US9284284, 9	Beta-secretase 2			 30					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213718&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549952	329729236							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375828	COCCOc1cnc2c(Nc3ccc(F)c(c3)[C@@]3(COCC(N)=N3)C(F)F)nccc2c1	InChI=1S/C22H22F3N5O3/c1-31-6-7-33-15-8-13-4-5-27-20(19(13)28-10-15)29-14-2-3-17(23)16(9-14)22(21(24)25)12-32-11-18(26)30-22/h2-5,8-10,21H,6-7,11-12H2,1H3,(H2,26,30)(H,27,29)/t22-/m0/s1	VPJLMCOWNDPWKS-QFIPXVFZSA-N	213719	US9284284, 10	Beta-secretase 2			 8200					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213719&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549954	329729237							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375829	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2nccc3cc(OCCCl)cnc23)ccc1F	InChI=1S/C21H19ClF3N5O2/c22-4-6-32-14-7-12-3-5-27-19(18(12)28-9-14)29-13-1-2-16(23)15(8-13)21(20(24)25)11-31-10-17(26)30-21/h1-3,5,7-9,20H,4,6,10-11H2,(H2,26,30)(H,27,29)/t21-/m0/s1	WKXJFKGDXFNTNH-NRFANRHFSA-N	213720	US9284284, 11	Beta-secretase 2			 5600					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213720&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71549955	329729238							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375830	Cc1cn2ccnc(Nc3ccc(F)c(c3)[C@@]3(COCC(N)=N3)C(F)F)c2n1	InChI=1S/C18H17F3N6O/c1-10-7-27-5-4-23-15(16(27)24-10)25-11-2-3-13(19)12(6-11)18(17(20)21)9-28-8-14(22)26-18/h2-7,17H,8-9H2,1H3,(H2,22,26)(H,23,25)/t18-/m0/s1	SVCVFKHLSFFKPD-SFHVURJKSA-N	213721	US9284284, 12	Beta-secretase 2			 72					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213721	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213721&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550087	329729239							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375831	CC1=N[C@](COC1)(C(F)F)c1cc(Nc2nccn3ccnc23)ccc1F	InChI=1S/C18H16F3N5O/c1-11-9-27-10-18(25-11,17(20)21)13-8-12(2-3-14(13)19)24-15-16-23-5-7-26(16)6-4-22-15/h2-8,17H,9-10H2,1H3,(H,22,24)/t18-/m0/s1	QWEPSFBIRVVVPL-SFHVURJKSA-N	213722	US9284284, 13	Beta-secretase 2			 410					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213722	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213722&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90394097	329729240							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375832	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2nccn3c(Br)cnc23)ccc1F	InChI=1S/C17H14BrF3N6O/c18-12-6-24-15-14(23-3-4-27(12)15)25-9-1-2-11(19)10(5-9)17(16(20)21)8-28-7-13(22)26-17/h1-6,16H,7-8H2,(H2,22,26)(H,23,25)/t17-/m0/s1	BJZKNBJZMFMEOE-KRWDZBQOSA-N	213723	US9284284, 14	Beta-secretase 2			 1400					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213723	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213723&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550089	329729241							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375833	COc1cccnc1Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F	InChI=1S/C17H17F3N4O2/c1-25-13-3-2-6-22-15(13)23-10-4-5-12(18)11(7-10)17(16(19)20)9-26-8-14(21)24-17/h2-7,16H,8-9H2,1H3,(H2,21,24)(H,22,23)/t17-/m0/s1	XJJGBQFMBPQWRK-KRWDZBQOSA-N	213724	US9284284, 15	Beta-secretase 2			 89					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213724	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213724&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550090	329729242							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375834	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2ncccn2)ccc1F	InChI=1S/C15H14F3N5O/c16-11-3-2-9(22-14-20-4-1-5-21-14)6-10(11)15(13(17)18)8-24-7-12(19)23-15/h1-6,13H,7-8H2,(H2,19,23)(H,20,21,22)/t15-/m0/s1	FBODVRNZZXUAQO-HNNXBMFYSA-N	213725	US9284284, 16	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213725&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550091	329729243							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375835	COc1ccnc(Nc2ccc(F)c(c2)[C@@]2(COCC(N)=N2)C(F)F)n1	InChI=1S/C16H16F3N5O2/c1-25-13-4-5-21-15(23-13)22-9-2-3-11(17)10(6-9)16(14(18)19)8-26-7-12(20)24-16/h2-6,14H,7-8H2,1H3,(H2,20,24)(H,21,22,23)/t16-/m0/s1	ZVVHGCHZVFJFGH-INIZCTEOSA-N	213726	US9284284, 17	Beta-secretase 2			 670					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213726	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213726&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550092	329729244							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375836	COc1nccnc1Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F	InChI=1S/C16H16F3N5O2/c1-25-14-13(21-4-5-22-14)23-9-2-3-11(17)10(6-9)16(15(18)19)8-26-7-12(20)24-16/h2-6,15H,7-8H2,1H3,(H2,20,24)(H,21,23)/t16-/m0/s1	FOXRQWMEUJAVSI-INIZCTEOSA-N	213727	US9284284, 18	Beta-secretase 2			 1300					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213727&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550093	329729245							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375837	CCOc1cccnc1Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F	InChI=1S/C18H19F3N4O2/c1-2-27-14-4-3-7-23-16(14)24-11-5-6-13(19)12(8-11)18(17(20)21)10-26-9-15(22)25-18/h3-8,17H,2,9-10H2,1H3,(H2,22,25)(H,23,24)/t18-/m0/s1	DXSUWZXOEJTTEK-SFHVURJKSA-N	213728	US9284284, 19	Beta-secretase 2			 160					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213728&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550219	329729246							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375838	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2ncccc2OCC(F)F)ccc1F	InChI=1S/C18H17F5N4O2/c19-12-4-3-10(26-16-13(2-1-5-25-16)29-7-14(20)21)6-11(12)18(17(22)23)9-28-8-15(24)27-18/h1-6,14,17H,7-9H2,(H2,24,27)(H,25,26)/t18-/m0/s1	CIKVIYFCFMSDCC-SFHVURJKSA-N	213729	US9284284, 20	Beta-secretase 2			 220					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213729	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213729&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550507	329729247							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375839	COc1cncnc1Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F	InChI=1S/C16H16F3N5O2/c1-25-12-5-21-8-22-14(12)23-9-2-3-11(17)10(4-9)16(15(18)19)7-26-6-13(20)24-16/h2-5,8,15H,6-7H2,1H3,(H2,20,24)(H,21,22,23)/t16-/m0/s1	UUWNFSRJFSYNFG-INIZCTEOSA-N	213730	US9284284, 21	Beta-secretase 2			 560					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213730	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213730&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550220	329729248							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375840	NC1=N[C@](COC1)(C(F)F)c1cc(Nc2ncccc2OC(F)F)ccc1F	InChI=1S/C17H15F5N4O2/c18-11-4-3-9(25-14-12(28-16(21)22)2-1-5-24-14)6-10(11)17(15(19)20)8-27-7-13(23)26-17/h1-6,15-16H,7-8H2,(H2,23,26)(H,24,25)/t17-/m0/s1	DIRLKEDRYQRESC-KRWDZBQOSA-N	213731	US9284284, 22	Beta-secretase 2			 340					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550368	329729249							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375841	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(Nc2ncnc3cc(Cl)cnc23)ccc1F	InChI=1S/C20H17ClF4N6O/c1-18(8-32-19(2,17(26)31-18)20(23,24)25)12-6-11(3-4-13(12)22)30-16-15-14(28-9-29-16)5-10(21)7-27-15/h3-7,9H,8H2,1-2H3,(H2,26,31)(H,28,29,30)/t18-,19+/m0/s1	UKTPFPDAFCJVOO-RBUKOAKNSA-N	213732	US9284284, 23	Beta-secretase 2			 11					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213732&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550221	329729250							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375842	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(Nc2ncnc3cc(cnc23)C(F)(F)F)ccc1F	InChI=1S/C21H17F7N6O/c1-18(8-35-19(2,17(29)34-18)21(26,27)28)12-6-11(3-4-13(12)22)33-16-15-14(31-9-32-16)5-10(7-30-15)20(23,24)25/h3-7,9H,8H2,1-2H3,(H2,29,34)(H,31,32,33)/t18-,19+/m0/s1	YVWNIBGRPWQPFV-RBUKOAKNSA-N	213733	US9284284, 24	Beta-secretase 2			 280					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213733&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550222	329729251							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375843	COc1cccnc1Nc1ccc(F)c(c1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C19H20F4N4O2/c1-17(10-29-18(2,16(24)27-17)19(21,22)23)12-9-11(6-7-13(12)20)26-15-14(28-3)5-4-8-25-15/h4-9H,10H2,1-3H3,(H2,24,27)(H,25,26)/t17-,18+/m0/s1	QYOZAFLHUMEJQT-ZWKOTPCHSA-N	213734	US9284284, 25	Beta-secretase 2			 27					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213734&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550223	329729252							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375844	COc1cc(cnc1Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F)[N+]([O-])=O	InChI=1S/C17H16F3N5O4/c1-28-13-5-10(25(26)27)6-22-15(13)23-9-2-3-12(18)11(4-9)17(16(19)20)8-29-7-14(21)24-17/h2-6,16H,7-8H2,1H3,(H2,21,24)(H,22,23)/t17-/m0/s1	MALBXUIZEBZONF-KRWDZBQOSA-N	213735	US9284284, 26	Beta-secretase 2			 1400					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213735	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213735&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550224	329729253							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375845	COc1cc(N)cnc1Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F	InChI=1S/C17H18F3N5O2/c1-26-13-4-9(21)6-23-15(13)24-10-2-3-12(18)11(5-10)17(16(19)20)8-27-7-14(22)25-17/h2-6,16H,7-8,21H2,1H3,(H2,22,25)(H,23,24)/t17-/m0/s1	BULJFAPFXZXMNJ-KRWDZBQOSA-N	213736	US9284284, 27	Beta-secretase 2			 660					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213736&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550508	329729254							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375846	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(Nc2ncnc3cc(cnc23)C(F)(F)F)ccc1F	InChI=1S/C20H16F7N7O/c1-17(7-35-18(2,16(28)34-17)20(25,26)27)14-10(21)3-4-12(32-14)33-15-13-11(30-8-31-15)5-9(6-29-13)19(22,23)24/h3-6,8H,7H2,1-2H3,(H2,28,34)(H,30,31,32,33)/t17-,18+/m0/s1	NTKVVULXBBNHFM-ZWKOTPCHSA-N	213737	US9284284, 28	Beta-secretase 2			 200					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213737&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550363	329729255							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375847	COc1ccccc1Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C19H20F4N4O2/c1-17(10-29-18(2,16(24)27-17)19(21,22)23)15-11(20)8-9-14(26-15)25-12-6-4-5-7-13(12)28-3/h4-9H,10H2,1-3H3,(H2,24,27)(H,25,26)/t17-,18+/m0/s1	OCCFUDYHZHVICL-ZWKOTPCHSA-N	213738	US9284284, 29	Beta-secretase 2			 4200					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213738&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550364	329729256							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375848	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(Nc2ncccc2C#N)ccc1F	InChI=1S/C18H16F4N6O/c1-16(9-29-17(2,15(24)28-16)18(20,21)22)13-11(19)5-6-12(26-13)27-14-10(8-23)4-3-7-25-14/h3-7H,9H2,1-2H3,(H2,24,28)(H,25,26,27)/t16-,17+/m0/s1	RNILDPYSUMNZGG-DLBZAZTESA-N	213739	US9284284, 30	Beta-secretase 2			 1600					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213739&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550365	329729257							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375849	COc1cccnc1Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C18H19F4N5O2/c1-16(9-29-17(2,15(23)27-16)18(20,21)22)13-10(19)6-7-12(25-13)26-14-11(28-3)5-4-8-24-14/h4-8H,9H2,1-3H3,(H2,23,27)(H,24,25,26)/t16-,17+/m0/s1	MLQXAUFWLNAFMN-DLBZAZTESA-N	213740	US9284284, 31	Beta-secretase 2			 1700					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213740	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213740&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550366	329729258							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
375850	Cn1nc(Nc2cccc(c2)[C@]2(C)COCC(N)=N2)c2ccccc12	InChI=1S/C19H21N5O/c1-19(12-25-11-17(20)22-19)13-6-5-7-14(10-13)21-18-15-8-3-4-9-16(15)24(2)23-18/h3-10H,11-12H2,1-2H3,(H2,20,22)(H,21,23)/t19-/m0/s1	LOEXEBKBXGBOKS-IBGZPJMESA-N	213741	US9284284, 32	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q25D8QP0		aid1802413	US9284284	Hurth, K; Jacquier, S; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213741&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71550367	329729259							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412131	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N4O4S/c1-19(2)18(23)26-20(10-30-9-16(20)31(19,28)29)13-7-12(4-5-14(13)22)25-17(27)15-6-3-11(21)8-24-15/h3-8,16H,9-10H2,1-2H3,(H2,23,26)(H,25,27)/t16-,20-/m1/s1	DKJRLRREDSNOQU-OXQOHEQNSA-N	236574	US9365589, 1a	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236574	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236574&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901536	340130161							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412132	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H20ClFN4O4S/c1-19(2)18(23)26-20(10-30-9-16(20)31(19,28)29)13-7-12(4-5-14(13)22)25-17(27)15-6-3-11(21)8-24-15/h3-8,16H,9-10H2,1-2H3,(H2,23,26)(H,25,27)/t16-,20-/m1/s1	RBWDTACROFJINQ-OXQOHEQNSA-N	236575	US9365589, 1b	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236575&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901537	340130162							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412133	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C21H23FN4O5S/c1-20(2)19(23)26-21(11-31-10-17(21)32(20,28)29)14-8-12(4-6-15(14)22)25-18(27)16-7-5-13(30-3)9-24-16/h4-9,17H,10-11H2,1-3H3,(H2,23,26)(H,25,27)/t17-,21-/m1/s1	CHEXVAMVBKFRSG-DYESRHJHSA-N	236576	US9365589, 1c	Beta-secretase 2		 3						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236576	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236576&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901538	340130163							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412134	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C20H22FN5O5S/c1-19(2)18(22)26-20(10-31-9-15(20)32(19,28)29)12-6-11(4-5-13(12)21)25-17(27)14-7-24-16(30-3)8-23-14/h4-8,15H,9-10H2,1-3H3,(H2,22,26)(H,25,27)/t15-,20-/m1/s1	RYTDXAUGIXLKCB-FOIQADDNSA-N	236577	US9365589, 1d	Beta-secretase 2		 5						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236577	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236577&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901539	340130164							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412135	Cn1ccc(n1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C19H22FN5O4S/c1-18(2)17(21)23-19(10-29-9-15(19)30(18,27)28)12-8-11(4-5-13(12)20)22-16(26)14-6-7-25(3)24-14/h4-8,15H,9-10H2,1-3H3,(H2,21,23)(H,22,26)/t15-,19-/m1/s1	NBPRYPJSRQEILS-DNVCBOLYSA-N	236578	US9365589, 1e	Beta-secretase 2		 2						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236578&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901540	340130165							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412136	Cc1cc(no1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C19H21FN4O5S/c1-10-6-14(24-29-10)16(25)22-11-4-5-13(20)12(7-11)19-9-28-8-15(19)30(26,27)18(2,3)17(21)23-19/h4-7,15H,8-9H2,1-3H3,(H2,21,23)(H,22,25)/t15-,19-/m1/s1	VZSTXFJDQAXBJE-DNVCBOLYSA-N	236579	US9365589, 1f	Beta-secretase 2		 24						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236579&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901541	340130166							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412137	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cn3ccsc3n2)ccc1F	InChI=1S/C20H20FN5O4S2/c1-19(2)17(22)25-20(10-30-9-15(20)32(19,28)29)12-7-11(3-4-13(12)21)23-16(27)14-8-26-5-6-31-18(26)24-14/h3-8,15H,9-10H2,1-2H3,(H2,22,25)(H,23,27)/t15-,20-/m1/s1	VQDFIYULPDJNBF-FOIQADDNSA-N	236580	US9365589, 1g	Beta-secretase 2		 3						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236580	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236580&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901728	340130167							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412138	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(OCCF)cn2)ccc1F	InChI=1S/C21H23F2N5O5S/c1-20(2)19(24)28-21(11-32-10-16(21)34(20,30)31)13-7-12(3-4-14(13)23)27-18(29)15-8-26-17(9-25-15)33-6-5-22/h3-4,7-9,16H,5-6,10-11H2,1-2H3,(H2,24,28)(H,27,29)/t16-,21-/m1/s1	KGEIVFLLAMBUQN-IIBYNOLFSA-N	236581	US9365589, 1h	Beta-secretase 2		 18						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236581	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236581&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901729	340130168							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412139	Cc1cc(on1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C19H21FN4O5S/c1-10-6-14(29-24-10)16(25)22-11-4-5-13(20)12(7-11)19-9-28-8-15(19)30(26,27)18(2,3)17(21)23-19/h4-7,15H,8-9H2,1-3H3,(H2,21,23)(H,22,25)/t15-,19-/m1/s1	FEMWSSPRLYMZMH-DNVCBOLYSA-N	236582	US9365589, 1i	Beta-secretase 2		 93						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236582	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236582&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901730	340130169							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412140	Cn1cc(C(=O)Nc2ccc(F)c(c2)[C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c(n1)C(F)(F)F	InChI=1S/C20H21F4N5O4S/c1-18(2)17(25)27-19(9-33-8-14(19)34(18,31)32)12-6-10(4-5-13(12)21)26-16(30)11-7-29(3)28-15(11)20(22,23)24/h4-7,14H,8-9H2,1-3H3,(H2,25,27)(H,26,30)/t14-,19-/m1/s1	JHDCKQDPQKPIPV-AUUYWEPGSA-N	236583	US9365589, 1j	Beta-secretase 2		 309						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236583	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236583&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901731	340130170							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412141	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F	InChI=1S/C20H19ClF2N4O4S/c1-19(2)18(24)27-20(9-31-8-15(20)32(19,29)30)12-6-11(3-4-13(12)22)26-17(28)16-14(23)5-10(21)7-25-16/h3-7,15H,8-9H2,1-2H3,(H2,24,27)(H,26,28)/t15-,20-/m1/s1	LOUMLSMKYFDHDL-FOIQADDNSA-N	236584	US9365589, 1k	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236584	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236584&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901732	340130171							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412142	Cc1nc(C(=O)Nc2ccc(F)c(c2)[C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c(C)o1	InChI=1S/C20H23FN4O5S/c1-10-16(23-11(2)30-10)17(26)24-12-5-6-14(21)13(7-12)20-9-29-8-15(20)31(27,28)19(3,4)18(22)25-20/h5-7,15H,8-9H2,1-4H3,(H2,22,25)(H,24,26)/t15-,20-/m1/s1	QQELOIUXHNPFCT-FOIQADDNSA-N	236585	US9365589, 1l	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236585	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236585&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901921	340130172							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412143	COCC(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C17H22FN3O5S/c1-16(2)15(19)21-17(9-26-7-13(17)27(16,23)24)11-6-10(4-5-12(11)18)20-14(22)8-25-3/h4-6,13H,7-9H2,1-3H3,(H2,19,21)(H,20,22)/t13-,17-/m1/s1	ODFHWGXAJALDTE-CXAGYDPISA-N	236586	US9365589, 1m	Beta-secretase 2		 5						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236586&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901922	340130173							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412144	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)C(F)F)ccc1F	InChI=1S/C16H18F3N3O4S/c1-15(2)14(20)22-16(7-26-6-11(16)27(15,24)25)9-5-8(3-4-10(9)17)21-13(23)12(18)19/h3-5,11-12H,6-7H2,1-2H3,(H2,20,22)(H,21,23)/t11-,16-/m1/s1	OLHNQUAKOSLLLA-BDJLRTHQSA-N	236587	US9365589, 1n	Beta-secretase 2		 33						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236587	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236587&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901923	340130174							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412145	CO[C@@H](C)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C18H24FN3O5S/c1-10(26-4)15(23)21-11-5-6-13(19)12(7-11)18-9-27-8-14(18)28(24,25)17(2,3)16(20)22-18/h5-7,10,14H,8-9H2,1-4H3,(H2,20,22)(H,21,23)/t10-,14+,18+/m0/s1	HDZXDROMEIJJHI-DGVXXNCNSA-N	236588	US9365589, 1o	Beta-secretase 2		 42						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236588	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236588&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901925	340130175							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412146	CO[C@H](C)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C18H24FN3O5S/c1-10(26-4)15(23)21-11-5-6-13(19)12(7-11)18-9-27-8-14(18)28(24,25)17(2,3)16(20)22-18/h5-7,10,14H,8-9H2,1-4H3,(H2,20,22)(H,21,23)/t10-,14-,18-/m1/s1	HDZXDROMEIJJHI-MAZCYNQFSA-N	236589	US9365589, 1p	Beta-secretase 2		 16						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236589&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901924	340130176							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412147	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)(F)F)ccc1F	InChI=1S/C20H19F4N5O4S/c1-18(2)17(25)29-19(9-33-8-15(19)34(18,31)32)11-5-10(3-4-12(11)21)28-16(30)13-6-27-14(7-26-13)20(22,23)24/h3-7,15H,8-9H2,1-2H3,(H2,25,29)(H,28,30)/t15-,19-/m1/s1	JYIQWWRKQIZMJL-DNVCBOLYSA-N	236590	US9365589, 1q	Beta-secretase 2		 35						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236590	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236590&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76901926	340130177							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412148	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H20FN5O4S/c1-20(2)19(24)27-21(11-31-10-17(21)32(20,29)30)14-7-13(4-5-15(14)22)26-18(28)16-6-3-12(8-23)9-25-16/h3-7,9,17H,10-11H2,1-2H3,(H2,24,27)(H,26,28)/t17-,21-/m1/s1	ZRQWZDZYZAYTLY-DYESRHJHSA-N	236591	US9365589, 1r	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236591&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			75593331	340130178							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412149	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c(C)c1	InChI=1S/C22H25FN4O5S/c1-12-7-14(31-4)9-25-18(12)19(28)26-13-5-6-16(23)15(8-13)22-11-32-10-17(22)33(29,30)21(2,3)20(24)27-22/h5-9,17H,10-11H2,1-4H3,(H2,24,27)(H,26,28)/t17-,22-/m1/s1	MXJYVOXJEQBXCB-VGOFRKELSA-N	236592	US9365589, 1s	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236592	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236592&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			117869742	340130179							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412150	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c(C)n1	InChI=1S/C21H24FN5O5S/c1-11-17(24-8-16(25-11)31-4)18(28)26-12-5-6-14(22)13(7-12)21-10-32-9-15(21)33(29,30)20(2,3)19(23)27-21/h5-8,15H,9-10H2,1-4H3,(H2,23,27)(H,26,28)/t15-,21-/m1/s1	FOIHZJCWPSRSAG-QVKFZJNVSA-N	236593	US9365589, 1t	Beta-secretase 2		 6						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236593	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236593&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902113	340130180							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412151	Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@H]1S(=O)(=O)C(C)(C)C(=N)N2)C#N	InChI=1S/C22H22FN5O4S/c1-12-6-13(8-24)9-26-18(12)19(29)27-14-4-5-16(23)15(7-14)22-11-32-10-17(22)33(30,31)21(2,3)20(25)28-22/h4-7,9,17H,10-11H2,1-3H3,(H2,25,28)(H,27,29)/t17-,22-/m1/s1	WPFPYTKQXHYXQI-VGOFRKELSA-N	236594	US9365589, 1u	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236594	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236594&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902114	340130181							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412152	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnsn2)ccc1F	InChI=1S/C17H18FN5O4S2/c1-16(2)15(19)22-17(8-27-7-13(17)29(16,25)26)10-5-9(3-4-11(10)18)21-14(24)12-6-20-28-23-12/h3-6,13H,7-8H2,1-2H3,(H2,19,22)(H,21,24)/t13-,17-/m1/s1	NBXVSRKCBQOQQR-CXAGYDPISA-N	236595	US9365589, 1v	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236595	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236595&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118553297	340130182							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412153	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H22FN5O5S/c1-4-7-33-18-10-25-16(9-26-18)19(29)27-13-5-6-15(23)14(8-13)22-12-32-11-17(22)34(30,31)21(2,3)20(24)28-22/h1,5-6,8-10,17H,7,11-12H2,2-3H3,(H2,24,28)(H,27,29)/t17-,22-/m1/s1	PEMSCVBYSDLRID-VGOFRKELSA-N	236596	US9365589, 1w	Beta-secretase 2		 2						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236596&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902116	340130183							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412154	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C21H22F2N4O5S/c1-20(2)19(24)27-21(10-31-9-17(21)33(20,29)30)14-7-12(3-5-15(14)23)26-18(28)16-6-4-13(8-25-16)32-11-22/h3-8,17H,9-11H2,1-2H3,(H2,24,27)(H,26,28)/t17-,21-/m1/s1	MRPOVUYUXMRWJP-DYESRHJHSA-N	236597	US9365589, 1x	Beta-secretase 2		 2						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236597	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236597&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118553298	340130184							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412155	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(OCC#C)cn2)ccc1F	InChI=1S/C23H23FN4O5S/c1-4-9-33-15-6-8-18(26-11-15)20(29)27-14-5-7-17(24)16(10-14)23-13-32-12-19(23)34(30,31)22(2,3)21(25)28-23/h1,5-8,10-11,19H,9,12-13H2,2-3H3,(H2,25,28)(H,27,29)/t19-,23-/m1/s1	ZKRIRTXSSDEWSN-AUSIDOKSSA-N	236598	US9365589, 1y	Beta-secretase 2		 7						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236598&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902306	340130185							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412156	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccn(n2)C(F)F)ccc1F	InChI=1S/C19H20F3N5O4S/c1-18(2)16(23)25-19(9-31-8-14(19)32(18,29)30)11-7-10(3-4-12(11)20)24-15(28)13-5-6-27(26-13)17(21)22/h3-7,14,17H,8-9H2,1-2H3,(H2,23,25)(H,24,28)/t14-,19-/m1/s1	NPIIRQVWYWSNPQ-AUUYWEPGSA-N	236599	US9365589, 1z	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236599&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902117	340130186							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412157	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C21H20F4N4O4S/c1-19(2)18(26)29-20(10-33-9-16(20)34(19,31)32)13-7-12(4-5-14(13)22)28-17(30)15-6-3-11(8-27-15)21(23,24)25/h3-8,16H,9-10H2,1-2H3,(H2,26,29)(H,28,30)/t16-,20-/m1/s1	AETXDGYJUWMDJE-OXQOHEQNSA-N	236600	US9365589, 1aa	Beta-secretase 2		 8						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236600&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902307	340130187							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412158	CC1(C)C(=N)N[C@]2(COC(CF)[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H21F3N4O4S/c1-20(2)19(25)28-21(10-32-16(8-22)17(21)33(20,30)31)13-7-12(4-5-14(13)24)27-18(29)15-6-3-11(23)9-26-15/h3-7,9,16-17H,8,10H2,1-2H3,(H2,25,28)(H,27,29)/t16?,17-,21-/m1/s1	WBKZBNDBMVILOR-PBTLETOKSA-N	236601	US9365589, 4a::US9365589, 4b	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236601&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902308	340130188							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412159	CC1(C)C(=N)N[C@]2(COC(CF)[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H21F3N4O4S/c1-20(2)19(25)28-21(10-32-16(8-22)17(21)33(20,30)31)13-7-12(4-5-14(13)24)27-18(29)15-6-3-11(23)9-26-15/h3-7,9,16-17H,8,10H2,1-2H3,(H2,25,28)(H,27,29)/t16?,17-,21-/m1/s1	WBKZBNDBMVILOR-PBTLETOKSA-N	236601	US9365589, 4a::US9365589, 4b	Beta-secretase 2		 18						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236601&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902308	340130188							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412160	CC1(C)C(=N)N[C@]2(COC(CF)[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H21ClF2N4O4S/c1-20(2)19(25)28-21(10-32-16(8-23)17(21)33(20,30)31)13-7-12(4-5-14(13)24)27-18(29)15-6-3-11(22)9-26-15/h3-7,9,16-17H,8,10H2,1-2H3,(H2,25,28)(H,27,29)/t16?,17-,21-/m1/s1	JMJZBWONPXLNAL-PBTLETOKSA-N	236603	US9365589, 4c::US9365589, 4f	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236603&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902309	340130189							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412161	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]12COC(CF)[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C22H24F2N4O5S/c1-21(2)20(25)28-22(11-33-17(9-23)18(22)34(21,30)31)14-8-12(4-6-15(14)24)27-19(29)16-7-5-13(32-3)10-26-16/h4-8,10,17-18H,9,11H2,1-3H3,(H2,25,28)(H,27,29)/t17?,18-,22-/m1/s1	POWOFNJUGKWUOO-WMISUKIASA-N	236604	US9365589, 4d::US9365589, 4g	Beta-secretase 2		 3						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236604&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902499	340130190							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412162	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]12COC(CF)[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C21H23F2N5O5S/c1-20(2)19(24)28-21(10-33-15(7-22)17(21)34(20,30)31)12-6-11(4-5-13(12)23)27-18(29)14-8-26-16(32-3)9-25-14/h4-6,8-9,15,17H,7,10H2,1-3H3,(H2,24,28)(H,27,29)/t15?,17-,21-/m1/s1	KTQXEIXDVUZRFZ-NZAAYYPMSA-N	236605	US9365589, 4e::US9365589, 4h	Beta-secretase 2		 11						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236605&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902500	340130191							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412163	CC1(C)C(=N)N[C@]2(COC(CF)[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H21ClF2N4O4S/c1-20(2)19(25)28-21(10-32-16(8-23)17(21)33(20,30)31)13-7-12(4-5-14(13)24)27-18(29)15-6-3-11(22)9-26-15/h3-7,9,16-17H,8,10H2,1-2H3,(H2,25,28)(H,27,29)/t16?,17-,21-/m1/s1	JMJZBWONPXLNAL-PBTLETOKSA-N	236603	US9365589, 4c::US9365589, 4f	Beta-secretase 2		 13						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236603&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902309	340130189							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412164	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]12COC(CF)[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C22H24F2N4O5S/c1-21(2)20(25)28-22(11-33-17(9-23)18(22)34(21,30)31)14-8-12(4-6-15(14)24)27-19(29)16-7-5-13(32-3)10-26-16/h4-8,10,17-18H,9,11H2,1-3H3,(H2,25,28)(H,27,29)/t17?,18-,22-/m1/s1	POWOFNJUGKWUOO-WMISUKIASA-N	236604	US9365589, 4d::US9365589, 4g	Beta-secretase 2		 96						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236604&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902499	340130190							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412165	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]12COC(CF)[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C21H23F2N5O5S/c1-20(2)19(24)28-21(10-33-15(7-22)17(21)34(20,30)31)12-6-11(4-5-13(12)23)27-18(29)14-8-26-16(32-3)9-25-14/h4-6,8-9,15,17H,7,10H2,1-3H3,(H2,24,28)(H,27,29)/t15?,17-,21-/m1/s1	KTQXEIXDVUZRFZ-NZAAYYPMSA-N	236605	US9365589, 4e::US9365589, 4h	Beta-secretase 2		 476						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236605&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902500	340130191							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412166	C[C@@]1(C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F)c1ccc(F)cc1	InChI=1S/C25H21F3N4O4S/c1-24(14-2-4-15(26)5-3-14)23(29)32-25(13-36-12-21(25)37(24,34)35)18-10-17(7-8-19(18)28)31-22(33)20-9-6-16(27)11-30-20/h2-11,21H,12-13H2,1H3,(H2,29,32)(H,31,33)/t21-,24+,25-/m1/s1	PRVIEVNCYRFJJM-IEZKXTBUSA-N	236609	US9365589, 8a	Beta-secretase 2		 9						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236609&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118553321	340130192							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412167	C[C@]1(C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F)c1ccc(F)cc1	InChI=1S/C25H21F3N4O4S/c1-24(14-2-4-15(26)5-3-14)23(29)32-25(13-36-12-21(25)37(24,34)35)18-10-17(7-8-19(18)28)31-22(33)20-9-6-16(27)11-30-20/h2-11,21H,12-13H2,1H3,(H2,29,32)(H,31,33)/t21-,24-,25-/m1/s1	PRVIEVNCYRFJJM-NQHRYMMQSA-N	236610	US9365589, 8b	Beta-secretase 2		 1						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236610&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118553316	340130193							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412168	C[C@@H]1OC[C@@]2(NC(=N)C(C)(C)S(=O)(=O)[C@H]12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H22F2N4O4S/c1-11-17-21(10-31-11,27-19(24)20(2,3)32(17,29)30)14-8-13(5-6-15(14)23)26-18(28)16-7-4-12(22)9-25-16/h4-9,11,17H,10H2,1-3H3,(H2,24,27)(H,26,28)/t11-,17+,21+/m0/s1	CNUQXSYODYTLTM-PPJNFFCYSA-N	236611	US9365589, 10a	Beta-secretase 2		 4						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236611&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902502	340130194							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412169	C[C@H]1OC[C@@]2(NC(=N)C(C)(C)S(=O)(=O)[C@H]12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H22F2N4O4S/c1-11-17-21(10-31-11,27-19(24)20(2,3)32(17,29)30)14-8-13(5-6-15(14)23)26-18(28)16-7-4-12(22)9-25-16/h4-9,11,17H,10H2,1-3H3,(H2,24,27)(H,26,28)/t11-,17-,21-/m1/s1	CNUQXSYODYTLTM-PYDSDUHUSA-N	236612	US9365589, 10b	Beta-secretase 2		 2						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236612&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76902692	340130195							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412170	C[C@@]1(C2CC2)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H22F2N4O4S/c1-21(12-2-3-12)20(25)28-22(11-32-10-18(22)33(21,30)31)15-8-14(5-6-16(15)24)27-19(29)17-7-4-13(23)9-26-17/h4-9,12,18H,2-3,10-11H2,1H3,(H2,25,28)(H,27,29)/t18-,21-,22-/m1/s1	NCUUMPKADDPHGD-STZQEDGTSA-N	236613	US9365589, 13a	Beta-secretase 2		 6						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236613&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118553335	340130196							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
412171	C[C@]1(C2CC2)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H22F2N4O4S/c1-21(12-2-3-12)20(25)28-22(11-32-10-18(22)33(21,30)31)15-8-14(5-6-16(15)24)27-19(29)17-7-4-13(23)9-26-17/h4-9,12,18H,2-3,10-11H2,1H3,(H2,25,28)(H,27,29)/t18-,21+,22-/m1/s1	NCUUMPKADDPHGD-BVYCBKJFSA-N	236614	US9365589, 13b	Beta-secretase 2		 11						5		US Patent		10.7270/Q2QZ28V2		aid1803095	US9365589	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Wu, W; Burnett, DA	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236614&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118553338	340130197							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425639	CN[S@@]1(O)C[C@](C)(NC(=N)N1C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H22ClFN6O2S/c1-18(10-29(28,22-2)26(3)17(21)25-18)13-8-12(5-6-14(13)20)24-16(27)15-7-4-11(19)9-23-15/h4-9,22,28H,10H2,1-3H3,(H2,21,25)(H,24,27)/t18-/m0/s1	VFRMWJSJMHBDCM-SFHVURJKSA-N	244045	US9428476, 1a	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244045&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129626252	341095770							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425640	CN[S@]1(O)C[C@](C)(NC(=N)N1C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H22ClFN6O2S/c1-18(10-29(28,22-2)26(3)17(21)25-18)13-8-12(5-6-14(13)20)24-16(27)15-7-4-11(19)9-23-15/h4-9,22,28H,10H2,1-3H3,(H2,21,25)(H,24,27)/t18-/m0/s1	VFRMWJSJMHBDCM-SFHVURJKSA-N	244046	US9428476, 1b	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244046&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129626252	341095771							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425641	CN[S@@]1(O)C[C@](C)(NC(=N)N1C)c1cc(NC(=O)c2ccc(OC)cn2)ccc1F	InChI=1S/C19H25FN6O3S/c1-19(11-30(28,22-2)26(3)18(21)25-19)14-9-12(5-7-15(14)20)24-17(27)16-8-6-13(29-4)10-23-16/h5-10,22,28H,11H2,1-4H3,(H2,21,25)(H,24,27)/t19-/m0/s1	VZNMUSBVXSORSX-IBGZPJMESA-N	244047	US9428476, 2a	Beta-secretase 2		 12						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244047&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129626253	341095772							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425642	CN[S@@]1(O)C[C@](C)(NC(=N)N1C)c1cc(NC(=O)COC)ccc1F	InChI=1S/C15H24FN5O3S/c1-15(9-25(23,18-2)21(3)14(17)20-15)11-7-10(5-6-12(11)16)19-13(22)8-24-4/h5-7,18,23H,8-9H2,1-4H3,(H2,17,20)(H,19,22)/t15-/m0/s1	QJIDGDPNMWTNMR-HNNXBMFYSA-N	244049	US9428476, 3a	Beta-secretase 2		 23						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244049&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129626254	341095774							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425643	CN[S@@]1(O)C[C@](C)(NC(=N)N1C)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H22F2N6O2S/c1-18(10-29(28,22-2)26(3)17(21)25-18)13-8-12(5-6-14(13)20)24-16(27)15-7-4-11(19)9-23-15/h4-9,22,28H,10H2,1-3H3,(H2,21,25)(H,24,27)/t18-/m0/s1	LIAVENAQWXAHHF-SFHVURJKSA-N	244050	US9428476, 4a	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244050&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129626255	341095775							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425644	CN[S@]1(O)C[C@](C)(NC(=N)N1C)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H22F2N6O2S/c1-18(10-29(28,22-2)26(3)17(21)25-18)13-8-12(5-6-14(13)20)24-16(27)15-7-4-11(19)9-23-15/h4-9,22,28H,10H2,1-3H3,(H2,21,25)(H,24,27)/t18-/m0/s1	LIAVENAQWXAHHF-SFHVURJKSA-N	244051	US9428476, 4b	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244051&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129626255	341095776							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425645	CCN=S1(=O)C[C@](C)(NC(=N)N1C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H22ClFN6O2S/c1-4-24-30(29)11-19(2,26-18(22)27(30)3)14-9-13(6-7-15(14)21)25-17(28)16-8-5-12(20)10-23-16/h5-10H,4,11H2,1-3H3,(H2,22,26)(H,25,28)/t19-,30?/m0/s1	UVKOPWYRMIEAMU-QUZMYUOTSA-N	244052	US9428476, 5	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244052&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86267655	341095777							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
425646	CCN1C(=N)N[C@@](C)(CS1(=O)=NC)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H22ClFN6O2S/c1-4-27-18(22)26-19(2,11-30(27,29)23-3)14-9-13(6-7-15(14)21)25-17(28)16-8-5-12(20)10-24-16/h5-10H,4,11H2,1-3H3,(H2,22,26)(H,25,28)/t19-,30?/m0/s1	ZQNYLKIEWDZUKV-QUZMYUOTSA-N	244053	US9428476, 6	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q2WQ02Q5		aid1803344	US9428476	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244053&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86267656	341095778							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423799	CN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H25ClFN5O2S/c1-19(2)18(23)27-20(3,11-30(19,29)24-4)14-9-13(6-7-15(14)22)26-17(28)16-8-5-12(21)10-25-16/h5-10,24,29H,11H2,1-4H3,(H2,23,27)(H,26,28)/t20-/m0/s1	IRHBPBKUEXETAX-FQEVSTJZSA-N	242918	US9422255, 1a	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242918&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625881	341095057							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423800	CN[S@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H25ClFN5O2S/c1-19(2)18(23)27-20(3,11-30(19,29)24-4)14-9-13(6-7-15(14)22)26-17(28)16-8-5-12(21)10-25-16/h5-10,24,29H,11H2,1-4H3,(H2,23,27)(H,26,28)/t20-/m0/s1	IRHBPBKUEXETAX-FQEVSTJZSA-N	242919	US9422255, 1b	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242919&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625881	341095058							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423801	CN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H25F2N5O2S/c1-19(2)18(23)27-20(3,11-30(19,29)24-4)14-9-13(6-7-15(14)22)26-17(28)16-8-5-12(21)10-25-16/h5-10,24,29H,11H2,1-4H3,(H2,23,27)(H,26,28)/t20-/m0/s1	RXLGQBLPZKLQKA-FQEVSTJZSA-N	242920	US9422255, 2a	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242920&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625882	341095059							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423802	CN[S@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H25F2N5O2S/c1-19(2)18(23)27-20(3,11-30(19,29)24-4)14-9-13(6-7-15(14)22)26-17(28)16-8-5-12(21)10-25-16/h5-10,24,29H,11H2,1-4H3,(H2,23,27)(H,26,28)/t20-/m0/s1	RXLGQBLPZKLQKA-FQEVSTJZSA-N	242921	US9422255, 2b	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242921&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625882	341095060							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423803	CN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(OC)cn2)ccc1F	InChI=1S/C21H28FN5O3S/c1-20(2)19(23)27-21(3,12-31(20,29)24-4)15-10-13(6-8-16(15)22)26-18(28)17-9-7-14(30-5)11-25-17/h6-11,24,29H,12H2,1-5H3,(H2,23,27)(H,26,28)/t21-/m0/s1	HIUCEFBTPIZRQJ-NRFANRHFSA-N	242922	US9422255, 3a	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242922&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625883	341095061							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423804	CN[S@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2cnc(OC)cn2)ccc1F	InChI=1S/C20H27FN6O3S/c1-19(2)18(22)27-20(3,11-31(19,29)23-4)13-8-12(6-7-14(13)21)26-17(28)15-9-25-16(30-5)10-24-15/h6-10,23,29H,11H2,1-5H3,(H2,22,27)(H,26,28)/t20-/m0/s1	RKURZQFUHCVKFF-FQEVSTJZSA-N	242923	US9422255, 4a	Beta-secretase 2		 12						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242923&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625884	341095062							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423805	CN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2cnc(OC)cn2)ccc1F	InChI=1S/C20H27FN6O3S/c1-19(2)18(22)27-20(3,11-31(19,29)23-4)13-8-12(6-7-14(13)21)26-17(28)15-9-25-16(30-5)10-24-15/h6-10,23,29H,11H2,1-5H3,(H2,22,27)(H,26,28)/t20-/m0/s1	RKURZQFUHCVKFF-FQEVSTJZSA-N	242924	US9422255, 4b	Beta-secretase 2		 32						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242924&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625884	341095063							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423806	CN[S@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)COC)ccc1F	InChI=1S/C17H27FN4O3S/c1-16(2)15(19)22-17(3,10-26(16,24)20-4)12-8-11(6-7-13(12)18)21-14(23)9-25-5/h6-8,20,24H,9-10H2,1-5H3,(H2,19,22)(H,21,23)/t17-/m0/s1	BMGUQHAOKLWIFB-KRWDZBQOSA-N	242925	US9422255, 5a	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242925&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625885	341095064							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423807	CN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)COC)ccc1F	InChI=1S/C17H27FN4O3S/c1-16(2)15(19)22-17(3,10-26(16,24)20-4)12-8-11(6-7-13(12)18)21-14(23)9-25-5/h6-8,20,24H,9-10H2,1-5H3,(H2,19,22)(H,21,23)/t17-/m0/s1	BMGUQHAOKLWIFB-KRWDZBQOSA-N	242926	US9422255, 5b	Beta-secretase 2		 36						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242926&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625885	341095065							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423808	CCN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H27ClFN5O2S/c1-5-26-31(30)12-21(4,28-19(24)20(31,2)3)15-10-14(7-8-16(15)23)27-18(29)17-9-6-13(22)11-25-17/h6-11,26,30H,5,12H2,1-4H3,(H2,24,28)(H,27,29)/t21-/m0/s1	LTQMYOXYKXFDQI-NRFANRHFSA-N	242927	US9422255, 6a	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242927&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625886	341095066							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423809	CCN[S@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H27ClFN5O2S/c1-5-26-31(30)12-21(4,28-19(24)20(31,2)3)15-10-14(7-8-16(15)23)27-18(29)17-9-6-13(22)11-25-17/h6-11,26,30H,5,12H2,1-4H3,(H2,24,28)(H,27,29)/t21-/m0/s1	LTQMYOXYKXFDQI-NRFANRHFSA-N	242928	US9422255, 6b	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242928&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625886	341095067							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423810	CCN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H27F2N5O2S/c1-5-26-31(30)12-21(4,28-19(24)20(31,2)3)15-10-14(7-8-16(15)23)27-18(29)17-9-6-13(22)11-25-17/h6-11,26,30H,5,12H2,1-4H3,(H2,24,28)(H,27,29)/t21-/m0/s1	PFKXSGPBKISYDH-NRFANRHFSA-N	242929	US9422255, 7a	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242929&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625887	341095068							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423811	CCN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H27FN6O2S/c1-5-27-32(31)13-22(4,29-20(25)21(32,2)3)16-10-15(7-8-17(16)23)28-19(30)18-9-6-14(11-24)12-26-18/h6-10,12,27,31H,5,13H2,1-4H3,(H2,25,29)(H,28,30)/t22-/m0/s1	AGUAJIQQHIKKCS-QFIPXVFZSA-N	242930	US9422255, 8a	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242930&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625888	341095069							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423812	CC1(C)C(=N)N[C@@](C)(C[S@]1(O)NCC1CC1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C23H29ClFN5O2S/c1-22(2)21(26)30-23(3,13-33(22,32)28-11-14-4-5-14)17-10-16(7-8-18(17)25)29-20(31)19-9-6-15(24)12-27-19/h6-10,12,14,28,32H,4-5,11,13H2,1-3H3,(H2,26,30)(H,29,31)/t23-/m0/s1	RROUPVVPXFNVCS-QHCPKHFHSA-N	242931	US9422255, 9a	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242931&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625889	341095070							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423813	CC1(C)C(=N)N[C@@](C)(C[S@@]1(O)NCC1CC1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C23H29ClFN5O2S/c1-22(2)21(26)30-23(3,13-33(22,32)28-11-14-4-5-14)17-10-16(7-8-18(17)25)29-20(31)19-9-6-15(24)12-27-19/h6-10,12,14,28,32H,4-5,11,13H2,1-3H3,(H2,26,30)(H,29,31)/t23-/m0/s1	RROUPVVPXFNVCS-QHCPKHFHSA-N	242932	US9422255, 9b	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242932&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625889	341095071							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423814	CN=S1(=O)C[C@](C)(NC(=N)[C@@]1(C)c1ccc(F)cc1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C25H24ClF2N5O2S/c1-24(14-36(35,30-3)25(2,23(29)33-24)15-4-7-17(27)8-5-15)19-12-18(9-10-20(19)28)32-22(34)21-11-6-16(26)13-31-21/h4-13H,14H2,1-3H3,(H2,29,33)(H,32,34)/t24-,25+,36?/m0/s1	VZIVUHOUMOSFOZ-FRTPCAPJSA-N	242933	US9422255, 10a	Beta-secretase 2		 106						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242933&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86271422	341095072							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423815	CC1(C)C(=N)N[C@@](C)(C[S@@]1(O)NCCF)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H26ClF2N5O2S/c1-20(2)19(25)29-21(3,12-32(20,31)27-9-8-23)15-10-14(5-6-16(15)24)28-18(30)17-7-4-13(22)11-26-17/h4-7,10-11,27,31H,8-9,12H2,1-3H3,(H2,25,29)(H,28,30)/t21-/m0/s1	HCHJSRXDRLUPOD-NRFANRHFSA-N	242934	US9422255, 11a	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242934&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625890	341095073							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423816	CC1(C)C(=N)N[C@@](C)(C[S@]1(O)NCCF)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H26ClF2N5O2S/c1-20(2)19(25)29-21(3,12-32(20,31)27-9-8-23)15-10-14(5-6-16(15)24)28-18(30)17-7-4-13(22)11-26-17/h4-7,10-11,27,31H,8-9,12H2,1-3H3,(H2,25,29)(H,28,30)/t21-/m0/s1	HCHJSRXDRLUPOD-NRFANRHFSA-N	242935	US9422255, 11b	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242935&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625890	341095074							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423817	COCCN[S@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H29ClFN5O3S/c1-21(2)20(25)29-22(3,13-33(21,31)27-9-10-32-4)16-11-15(6-7-17(16)24)28-19(30)18-8-5-14(23)12-26-18/h5-8,11-12,27,31H,9-10,13H2,1-4H3,(H2,25,29)(H,28,30)/t22-/m0/s1	BZXZUMDZEXZKSC-QFIPXVFZSA-N	242936	US9422255, 12a	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242936&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625891	341095075							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423818	COCCN[S@@]1(O)C[C@](C)(NC(=N)C1(C)C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H29ClFN5O3S/c1-21(2)20(25)29-22(3,13-33(21,31)27-9-10-32-4)16-11-15(6-7-17(16)24)28-19(30)18-8-5-14(23)12-26-18/h5-8,11-12,27,31H,9-10,13H2,1-4H3,(H2,25,29)(H,28,30)/t22-/m0/s1	BZXZUMDZEXZKSC-QFIPXVFZSA-N	242937	US9422255, 12b	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q20P0XXS		aid1803306	US9422255	Khan, TA; Scott, JD; Cumming, JN	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242937&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625891	341095076							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423904	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc([nH]1)-c1ccccc1			242938	US9422277, 1	Beta-secretase 2		 0.69						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242938&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73508019	341095077							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423905	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ncc([nH]1)-c1ccccc1			242939	US9422277, 2	Beta-secretase 2		 14.76						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242939&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775623	341095078							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423906	CN1\C(N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ncc([nH]1)-c1ccccn1)=N/C(=O)OC(C)(C)C			242940	US9422277, 3	Beta-secretase 2		 87.92						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242940&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775624	341095079							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423907	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1[nH]cnc1-c1ccccc1			242941	US9422277, 4	Beta-secretase 2		 3119						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242941&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775625	341095080							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423908	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cn(nn1)-c1ccccc1	InChI=1S/C17H17ClN6O2S2/c1-17(10-28(25,26)23(2)16(19)20-17)15-12(18)8-14(27-15)13-9-24(22-21-13)11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H2,19,20)/t17-/m0/s1	MZKKPHDUBNVBOF-KRWDZBQOSA-N	242942	US9422277, 5	Beta-secretase 2		 281.4						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242942&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775626	341095081							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423909	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc([nH]1)C1=NCCO1			242943	US9422277, 6	Beta-secretase 2		 69						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242943&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775746	341095082							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423910	CC1CN=C(O1)c1ccc([nH]1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1			242944	US9422277, 7	Beta-secretase 2		 35						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242944&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775747	341095083							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423911	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc([nH]1)-c1nnco1			242945	US9422277, 8	Beta-secretase 2		 10.91						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242945&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775748	341095084							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423912	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc([nH]1)-c1nnc(C)o1			242946	US9422277, 9	Beta-secretase 2		 8.243						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242946&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775749	341095085							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423913	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc([nH]1)-c1nnc(o1)C1CC1			242947	US9422277, 10	Beta-secretase 2		 11.29						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242947&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775750	341095086							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423914	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1ccc([nH]1)-c1nnco1			242948	US9422277, 11	Beta-secretase 2		 171.7						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242948&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775751	341095087							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423915	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cc(on1)-c1ccccc1	InChI=1S/C18H17ClN4O3S2/c1-18(10-28(24,25)23(2)17(20)21-18)16-12(19)8-15(27-16)13-9-14(26-22-13)11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H2,20,21)/t18-/m0/s1	AVWDUFMAWIGZRY-SFHVURJKSA-N	242949	US9422277, 12	Beta-secretase 2		 364.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242949&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775878	341095088							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423916	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1cc(on1)-c1ccccc1	InChI=1S/C20H19FN4O3S/c1-20(12-29(26,27)25(2)19(22)23-20)15-10-14(8-9-16(15)21)17-11-18(28-24-17)13-6-4-3-5-7-13/h3-11H,12H2,1-2H3,(H2,22,23)/t20-/m0/s1	TZRBTIDEKGRNBH-FQEVSTJZSA-N	242950	US9422277, 13::US9422277, 15	Beta-secretase 2		 206.9						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242950&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775879	341095089							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423917	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cc(no1)-c1ccccc1	InChI=1S/C18H17ClN4O3S2/c1-18(10-28(24,25)23(2)17(20)21-18)16-12(19)8-15(27-16)14-9-13(22-26-14)11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H2,20,21)/t18-/m0/s1	HCBDSDWWRIIBPU-SFHVURJKSA-N	242951	US9422277, 14	Beta-secretase 2		 143.6						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242951&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775880	341095090							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423918	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1cc(on1)-c1ccccc1	InChI=1S/C20H19FN4O3S/c1-20(12-29(26,27)25(2)19(22)23-20)15-10-14(8-9-16(15)21)17-11-18(28-24-17)13-6-4-3-5-7-13/h3-11H,12H2,1-2H3,(H2,22,23)/t20-/m0/s1	TZRBTIDEKGRNBH-FQEVSTJZSA-N	242950	US9422277, 13::US9422277, 15	Beta-secretase 2		 52.64						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242950&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775879	341095089							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423919	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C17H15Cl2N5O3S2/c1-17(8-29(25,26)24(2)16(20)21-17)13-11(19)7-12(28-13)15-23-22-14(27-15)9-3-5-10(18)6-4-9/h3-7H,8H2,1-2H3,(H2,20,21)/t17-/m0/s1	SBOIGHMLHNFAPB-KRWDZBQOSA-N	242953	US9422277, 16	Beta-secretase 2		 13.79						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242953&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775882	341095091							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423920	COc1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C18H18ClN5O4S2/c1-18(9-30(25,26)24(2)17(20)21-18)14-12(19)8-13(29-14)16-23-22-15(28-16)10-4-6-11(27-3)7-5-10/h4-8H,9H2,1-3H3,(H2,20,21)/t18-/m0/s1	OCVQNVHNXCLRSU-SFHVURJKSA-N	242954	US9422277, 17	Beta-secretase 2		 34.61						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242954&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775883	341095092							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423921	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)C(F)(F)F	InChI=1S/C18H15ClF3N5O3S2/c1-17(8-32(28,29)27(2)16(23)24-17)13-11(19)7-12(31-13)15-26-25-14(30-15)9-3-5-10(6-4-9)18(20,21)22/h3-7H,8H2,1-2H3,(H2,23,24)/t17-/m0/s1	OCRCZTPYWWJTJY-KRWDZBQOSA-N	242955	US9422277, 18	Beta-secretase 2		 154.7						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242955&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776015	341095093							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423922	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C17H15ClFN5O3S2/c1-17(8-29(25,26)24(2)16(20)21-17)13-11(19)7-12(28-13)15-23-22-14(27-15)9-3-5-10(18)6-4-9/h3-7H,8H2,1-2H3,(H2,20,21)/t17-/m0/s1	SCBFYVQPBSGHRL-KRWDZBQOSA-N	242956	US9422277, 19	Beta-secretase 2		 13.6						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242956&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776016	341095094							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423923	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccccc1	InChI=1S/C17H16ClN5O3S2/c1-17(9-28(24,25)23(2)16(19)20-17)13-11(18)8-12(27-13)15-22-21-14(26-15)10-6-4-3-5-7-10/h3-8H,9H2,1-2H3,(H2,19,20)/t17-/m0/s1	ZKKCLIHWNQRYQN-KRWDZBQOSA-N	242957	US9422277, 20	Beta-secretase 2		 7.762						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242957&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776017	341095095							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423924	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccccn1	InChI=1S/C16H15ClN6O3S2/c1-16(8-28(24,25)23(2)15(18)20-16)12-9(17)7-11(27-12)14-22-21-13(26-14)10-5-3-4-6-19-10/h3-7H,8H2,1-2H3,(H2,18,20)/t16-/m0/s1	RRUDJLAATVPDBZ-INIZCTEOSA-N	242958	US9422277, 21	Beta-secretase 2		 58.41						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242958&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776018	341095096							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423925	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(F)cc1	InChI=1S/C17H15ClFN5O3S2/c1-17(8-29(25,26)24(2)16(20)21-17)13-11(18)7-12(28-13)15-23-22-14(27-15)9-3-5-10(19)6-4-9/h3-7H,8H2,1-2H3,(H2,20,21)/t17-/m0/s1	GHVBKTVASKIYHA-KRWDZBQOSA-N	242959	US9422277, 22::US9422277, 84	Beta-secretase 2		 13.04						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242959&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776019	341095097							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423926	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)C#N	InChI=1S/C18H15ClN6O3S2/c1-18(9-30(26,27)25(2)17(21)22-18)14-12(19)7-13(29-14)16-24-23-15(28-16)11-5-3-10(8-20)4-6-11/h3-7H,9H2,1-2H3,(H2,21,22)/t18-/m0/s1	MROATOGGWCLFGC-SFHVURJKSA-N	242960	US9422277, 23	Beta-secretase 2		 44.92						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242960&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776020	341095098							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423927	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1ccccc1	InChI=1S/C19H18FN5O3S/c1-19(11-29(26,27)25(2)18(21)22-19)14-10-13(8-9-15(14)20)17-24-23-16(28-17)12-6-4-3-5-7-12/h3-10H,11H2,1-2H3,(H2,21,22)/t19-/m0/s1	LBAIGIRUNNKXKP-IBGZPJMESA-N	242961	US9422277, 24	Beta-secretase 2		 1492						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242961&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776159	341095099							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423928	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1ccc(Cl)cc1	InChI=1S/C19H17ClFN5O3S/c1-19(10-30(27,28)26(2)18(22)23-19)14-9-12(5-8-15(14)21)17-25-24-16(29-17)11-3-6-13(20)7-4-11/h3-9H,10H2,1-2H3,(H2,22,23)/t19-/m0/s1	WHQWMFSQEQLSFH-IBGZPJMESA-N	242962	US9422277, 25	Beta-secretase 2		 595.3						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242962&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776160	341095100							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423929	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1cnco1	InChI=1S/C16H15FN6O4S/c1-16(7-28(24,25)23(2)15(18)20-16)10-5-9(3-4-11(10)17)13-21-22-14(27-13)12-6-19-8-26-12/h3-6,8H,7H2,1-2H3,(H2,18,20)/t16-/m0/s1	PDEBELMNDDDCJC-INIZCTEOSA-N	242963	US9422277, 26	Beta-secretase 2		 801.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242963&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776161	341095101							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423930	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cnccn1	InChI=1S/C15H14ClN7O3S2/c1-15(7-28(24,25)23(2)14(17)20-15)11-8(16)5-10(27-11)13-22-21-12(26-13)9-6-18-3-4-19-9/h3-6H,7H2,1-2H3,(H2,17,20)/t15-/m0/s1	GCEWRWXQKXNTAP-HNNXBMFYSA-N	242964	US9422277, 27	Beta-secretase 2		 283.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242964&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118406555	341095102							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423931	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccncc1	InChI=1S/C16H15ClN6O3S2/c1-16(8-28(24,25)23(2)15(18)20-16)12-10(17)7-11(27-12)14-22-21-13(26-14)9-3-5-19-6-4-9/h3-7H,8H2,1-2H3,(H2,18,20)/t16-/m0/s1	TUZPFJIPIZPFOY-INIZCTEOSA-N	242965	US9422277, 28	Beta-secretase 2		 332.1						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242965&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118406554	341095103							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423932	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cccnc1	InChI=1S/C16H15ClN6O3S2/c1-16(8-28(24,25)23(2)15(18)20-16)12-10(17)6-11(27-12)14-22-21-13(26-14)9-4-3-5-19-7-9/h3-7H,8H2,1-2H3,(H2,18,20)/t16-/m0/s1	ITTILQQVSNQNRI-INIZCTEOSA-N	242966	US9422277, 29	Beta-secretase 2		 697.8						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242966&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776164	341095104							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423933	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cc2ccccn2n1	InChI=1S/C18H16ClN7O3S2/c1-18(9-31(27,28)25(2)17(20)21-18)14-11(19)8-13(30-14)16-23-22-15(29-16)12-7-10-5-3-4-6-26(10)24-12/h3-8H,9H2,1-2H3,(H2,20,21)/t18-/m0/s1	GABSDEJETZSODI-SFHVURJKSA-N	242967	US9422277, 30	Beta-secretase 2		 96.78						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242967&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776314	341095105							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423934	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cccc(c1)C#N	InChI=1S/C18H15ClN6O3S2/c1-18(9-30(26,27)25(2)17(21)22-18)14-12(19)7-13(29-14)16-24-23-15(28-16)11-5-3-4-10(6-11)8-20/h3-7H,9H2,1-2H3,(H2,21,22)/t18-/m0/s1	RTPAUPSFNJFFKR-SFHVURJKSA-N	242968	US9422277, 31	Beta-secretase 2		 1235						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242968&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776315	341095106							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423935	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1nccs1	InChI=1S/C14H13ClN6O3S3/c1-14(6-27(22,23)21(2)13(16)18-14)9-7(15)5-8(26-9)10-19-20-11(24-10)12-17-3-4-25-12/h3-5H,6H2,1-2H3,(H2,16,18)/t14-/m0/s1	PQWZZLJRUIWSHM-AWEZNQCLSA-N	242969	US9422277, 32	Beta-secretase 2		 44.29						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242969&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776316	341095107							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423936	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cncs1	InChI=1S/C14H13ClN6O3S3/c1-14(5-27(22,23)21(2)13(16)18-14)10-7(15)3-8(26-10)11-19-20-12(24-11)9-4-17-6-25-9/h3-4,6H,5H2,1-2H3,(H2,16,18)/t14-/m0/s1	CFIPNTQIGNAOLU-AWEZNQCLSA-N	242970	US9422277, 33	Beta-secretase 2		 346.9						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242970&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776317	341095108							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423937	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cccc2ccnn12	InChI=1S/C18H16ClN7O3S2/c1-18(9-31(27,28)25(2)17(20)22-18)14-11(19)8-13(30-14)16-24-23-15(29-16)12-5-3-4-10-6-7-21-26(10)12/h3-8H,9H2,1-2H3,(H2,20,22)/t18-/m0/s1	JUAQEFYMEHGHRP-SFHVURJKSA-N	242971	US9422277, 34	Beta-secretase 2		 217						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242971&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776318	341095109							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423938	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cnn2ccccc12	InChI=1S/C18H16ClN7O3S2/c1-18(9-31(27,28)25(2)17(20)22-18)14-11(19)7-13(30-14)16-24-23-15(29-16)10-8-21-26-6-4-3-5-12(10)26/h3-8H,9H2,1-2H3,(H2,20,22)/t18-/m0/s1	JPMFAXVXOFUKGQ-SFHVURJKSA-N	242972	US9422277, 35	Beta-secretase 2		 449.7						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242972&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776319	341095110							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423939	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ncccn1	InChI=1S/C15H14ClN7O3S2/c1-15(7-28(24,25)23(2)14(17)20-15)10-8(16)6-9(27-10)12-21-22-13(26-12)11-18-4-3-5-19-11/h3-6H,7H2,1-2H3,(H2,17,20)/t15-/m0/s1	YVXLHYGRGOHSRH-HNNXBMFYSA-N	242973	US9422277, 36	Beta-secretase 2		 104.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242973&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776458	341095111							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423940	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cscn1	InChI=1S/C14H13ClN6O3S3/c1-14(5-27(22,23)21(2)13(16)18-14)10-7(15)3-9(26-10)12-20-19-11(24-12)8-4-25-6-17-8/h3-4,6H,5H2,1-2H3,(H2,16,18)/t14-/m0/s1	REWUORFFNBSNFB-AWEZNQCLSA-N	242974	US9422277, 37	Beta-secretase 2		 69.07						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242974&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776459	341095112							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423941	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)C1Cc2ccccc2C1	InChI=1S/C20H20ClN5O3S2/c1-20(10-31(27,28)26(2)19(22)23-20)16-14(21)9-15(30-16)18-25-24-17(29-18)13-7-11-5-3-4-6-12(11)8-13/h3-6,9,13H,7-8,10H2,1-2H3,(H2,22,23)/t20-/m0/s1	CEBLWZGJDSRVFB-FQEVSTJZSA-N	242975	US9422277, 38	Beta-secretase 2		 124.3						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242975&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776460	341095113							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423942	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cncnc1	InChI=1S/C15H14ClN7O3S2/c1-15(6-28(24,25)23(2)14(17)20-15)11-9(16)3-10(27-11)13-22-21-12(26-13)8-4-18-7-19-5-8/h3-5,7H,6H2,1-2H3,(H2,17,20)/t15-/m0/s1	CWAHDLMWDXXDLR-HNNXBMFYSA-N	242976	US9422277, 39	Beta-secretase 2		 1659						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242976&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776461	341095114							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423943	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cnco1	InChI=1S/C14H13ClN6O4S2/c1-14(5-27(22,23)21(2)13(16)18-14)10-7(15)3-9(26-10)12-20-19-11(25-12)8-4-17-6-24-8/h3-4,6H,5H2,1-2H3,(H2,16,18)/t14-/m0/s1	MEWZQORZRFJYMZ-AWEZNQCLSA-N	242977	US9422277, 40	Beta-secretase 2		 141.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242977&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776462	341095115							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423944	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ncco1	InChI=1S/C14H13ClN6O4S2/c1-14(6-27(22,23)21(2)13(16)18-14)9-7(15)5-8(26-9)10-19-20-12(25-10)11-17-3-4-24-11/h3-5H,6H2,1-2H3,(H2,16,18)/t14-/m0/s1	LFWBCPDUZIJXPI-AWEZNQCLSA-N	242978	US9422277, 41	Beta-secretase 2		 31.68						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242978&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776463	341095116							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423945	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cocn1	InChI=1S/C14H13ClN6O4S2/c1-14(5-27(22,23)21(2)13(16)18-14)10-7(15)3-9(26-10)12-20-19-11(25-12)8-4-24-6-17-8/h3-4,6H,5H2,1-2H3,(H2,16,18)/t14-/m0/s1	WJVOVHMGLZNFFP-AWEZNQCLSA-N	242979	US9422277, 42	Beta-secretase 2		 142.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242979&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776599	341095117							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423946	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccncn1	InChI=1S/C15H14ClN7O3S2/c1-15(6-28(24,25)23(2)14(17)20-15)11-8(16)5-10(27-11)13-22-21-12(26-13)9-3-4-18-7-19-9/h3-5,7H,6H2,1-2H3,(H2,17,20)/t15-/m0/s1	NLONBIWGSJHHDO-HNNXBMFYSA-N	242980	US9422277, 43	Beta-secretase 2		 305.2						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242980&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776600	341095118							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423947	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccon1	InChI=1S/C14H13ClN6O4S2/c1-14(6-27(22,23)21(2)13(16)17-14)10-7(15)5-9(26-10)12-19-18-11(25-12)8-3-4-24-20-8/h3-5H,6H2,1-2H3,(H2,16,17)/t14-/m0/s1	WAFSYBQRXBRHQH-AWEZNQCLSA-N	242981	US9422277, 44	Beta-secretase 2		 156.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242981&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776601	341095119							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423948	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1cnn(C)c1	InChI=1S/C15H16ClN7O3S2/c1-15(7-28(24,25)23(3)14(17)19-15)11-9(16)4-10(27-11)13-21-20-12(26-13)8-5-18-22(2)6-8/h4-6H,7H2,1-3H3,(H2,17,19)/t15-/m0/s1	OGUXXBZPJZTFQL-HNNXBMFYSA-N	242982	US9422277, 45	Beta-secretase 2		 226						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242982&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776602	341095120							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423949	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccn(C)n1	InChI=1S/C15H16ClN7O3S2/c1-15(7-28(24,25)23(3)14(17)18-15)11-8(16)6-10(27-11)13-20-19-12(26-13)9-4-5-22(2)21-9/h4-6H,7H2,1-3H3,(H2,17,18)/t15-/m0/s1	NHLZXHMOOYYQIV-HNNXBMFYSA-N	242983	US9422277, 46	Beta-secretase 2		 129.5						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242983&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776603	341095121							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423950	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccnn1C	InChI=1S/C15H16ClN7O3S2/c1-15(7-28(24,25)23(3)14(17)19-15)11-8(16)6-10(27-11)13-21-20-12(26-13)9-4-5-18-22(9)2/h4-6H,7H2,1-3H3,(H2,17,19)/t15-/m0/s1	FFYIASIZWOXJSN-HNNXBMFYSA-N	242984	US9422277, 47	Beta-secretase 2		 712.4						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242984&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776604	341095122							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423951	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)C1CC1	InChI=1S/C14H16ClN5O3S2/c1-14(6-25(21,22)20(2)13(16)17-14)10-8(15)5-9(24-10)12-19-18-11(23-12)7-3-4-7/h5,7H,3-4,6H2,1-2H3,(H2,16,17)/t14-/m0/s1	ODAJKRKMLUSTCZ-AWEZNQCLSA-N	242985	US9422277, 48	Beta-secretase 2		 115.8						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242985&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776738	341095123							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423952	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1nccs1	InChI=1S/C16H15FN6O3S2/c1-16(8-28(24,25)23(2)15(18)20-16)10-7-9(3-4-11(10)17)12-21-22-13(26-12)14-19-5-6-27-14/h3-7H,8H2,1-2H3,(H2,18,20)/t16-/m0/s1	VDSAVKXPQQZHHL-INIZCTEOSA-N	242986	US9422277, 49	Beta-secretase 2		 489.8						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242986&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776739	341095124							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423953	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1cncs1	InChI=1S/C16H15FN6O3S2/c1-16(7-28(24,25)23(2)15(18)20-16)10-5-9(3-4-11(10)17)13-21-22-14(26-13)12-6-19-8-27-12/h3-6,8H,7H2,1-2H3,(H2,18,20)/t16-/m0/s1	RQVYBJKHAQNWKF-INIZCTEOSA-N	242987	US9422277, 50	Beta-secretase 2		 4220						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242987&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776740	341095125							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423954	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1cscn1	InChI=1S/C16H15FN6O3S2/c1-16(7-28(24,25)23(2)15(18)20-16)10-5-9(3-4-11(10)17)13-21-22-14(26-13)12-6-27-8-19-12/h3-6,8H,7H2,1-2H3,(H2,18,20)/t16-/m0/s1	YKWIHRBHYPEMDM-INIZCTEOSA-N	242988	US9422277, 51	Beta-secretase 2		 1535						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242988&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776741	341095126							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423955	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)C1Cc2ccccc2C1	InChI=1S/C22H22FN5O3S/c1-22(12-32(29,30)28(2)21(24)25-22)17-11-15(7-8-18(17)23)19-26-27-20(31-19)16-9-13-5-3-4-6-14(13)10-16/h3-8,11,16H,9-10,12H2,1-2H3,(H2,24,25)/t22-/m0/s1	CWVROUVHWABDHH-QFIPXVFZSA-N	242989	US9422277, 52	Beta-secretase 2		 2676						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242989&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776742	341095127							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423956	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1ncco1	InChI=1S/C16H15FN6O4S/c1-16(8-28(24,25)23(2)15(18)20-16)10-7-9(3-4-11(10)17)12-21-22-14(27-12)13-19-5-6-26-13/h3-7H,8H2,1-2H3,(H2,18,20)/t16-/m0/s1	MPPSPNKMZRUFQX-INIZCTEOSA-N	242990	US9422277, 53	Beta-secretase 2		 185.8						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242990&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776743	341095128							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423957	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1cocn1	InChI=1S/C16H15FN6O4S/c1-16(7-28(24,25)23(2)15(18)20-16)10-5-9(3-4-11(10)17)13-21-22-14(27-13)12-6-26-8-19-12/h3-6,8H,7H2,1-2H3,(H2,18,20)/t16-/m0/s1	XPOCTNNWCNRSBB-INIZCTEOSA-N	242991	US9422277, 54	Beta-secretase 2		 1686						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242991&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776881	341095129							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423958	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1nnc(o1)-c1ccon1	InChI=1S/C16H15FN6O4S/c1-16(8-28(24,25)23(2)15(18)19-16)10-7-9(3-4-11(10)17)13-20-21-14(27-13)12-5-6-26-22-12/h3-7H,8H2,1-2H3,(H2,18,19)/t16-/m0/s1	YEYGIOBLFJMMFV-INIZCTEOSA-N	242992	US9422277, 55	Beta-secretase 2		 736.6						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242992&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776882	341095130							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423959	CC(C)c1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C20H22ClN5O3S2/c1-11(2)12-5-7-13(8-6-12)17-24-25-18(29-17)15-9-14(21)16(30-15)20(3)10-31(27,28)26(4)19(22)23-20/h5-9,11H,10H2,1-4H3,(H2,22,23)/t20-/m0/s1	KLTFUOZRHPUBQI-FQEVSTJZSA-N	242993	US9422277, 56	Beta-secretase 2		 889.4						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242993&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776883	341095131							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423960	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(Cl)cc1F	InChI=1S/C17H14Cl2FN5O3S2/c1-17(7-30(26,27)25(2)16(21)22-17)13-10(19)6-12(29-13)15-24-23-14(28-15)9-4-3-8(18)5-11(9)20/h3-6H,7H2,1-2H3,(H2,21,22)/t17-/m0/s1	DPZRDYPERRHESC-KRWDZBQOSA-N	242994	US9422277, 57	Beta-secretase 2		 16.77						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242994&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776884	341095132							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423961	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc2[nH]cnc2c1			242995	US9422277, 58	Beta-secretase 2		 1299						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242995&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776885	341095133							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423962	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(F)c(F)c1	InChI=1S/C17H14ClF2N5O3S2/c1-17(7-30(26,27)25(2)16(21)22-17)13-9(18)6-12(29-13)15-24-23-14(28-15)8-3-4-10(19)11(20)5-8/h3-6H,7H2,1-2H3,(H2,21,22)/t17-/m0/s1	OYYYHXCXYIRVRS-KRWDZBQOSA-N	242996	US9422277, 59	Beta-secretase 2		 81.32						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242996&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776886	341095134							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423963	CC(C)Oc1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C20H22ClN5O4S2/c1-11(2)29-13-7-5-12(6-8-13)17-24-25-18(30-17)15-9-14(21)16(31-15)20(3)10-32(27,28)26(4)19(22)23-20/h5-9,11H,10H2,1-4H3,(H2,22,23)/t20-/m0/s1	QSYCYBKQBBYYBM-FQEVSTJZSA-N	242997	US9422277, 60	Beta-secretase 2		 532.8						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242997&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774748	341095135							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423964	CCCCOc1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C21H24ClN5O4S2/c1-4-5-10-30-14-8-6-13(7-9-14)18-25-26-19(31-18)16-11-15(22)17(32-16)21(2)12-33(28,29)27(3)20(23)24-21/h6-9,11H,4-5,10,12H2,1-3H3,(H2,23,24)/t21-/m0/s1	WWUXUBLNXWJJMH-NRFANRHFSA-N	242998	US9422277, 61	Beta-secretase 2		 257.6						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242998&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774749	341095136							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423965	CCCOc1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C20H22ClN5O4S2/c1-4-9-29-13-7-5-12(6-8-13)17-24-25-18(30-17)15-10-14(21)16(31-15)20(2)11-32(27,28)26(3)19(22)23-20/h5-8,10H,4,9,11H2,1-3H3,(H2,22,23)/t20-/m0/s1	KDUZPASAVLGXEN-FQEVSTJZSA-N	242999	US9422277, 62	Beta-secretase 2		 312.7						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242999&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774750	341095137							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423966	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(OCc2ccccc2)cc1	InChI=1S/C24H22ClN5O4S2/c1-24(14-36(31,32)30(2)23(26)27-24)20-18(25)12-19(35-20)22-29-28-21(34-22)16-8-10-17(11-9-16)33-13-15-6-4-3-5-7-15/h3-12H,13-14H2,1-2H3,(H2,26,27)/t24-/m0/s1	BIMQQOGSSDVRGM-DEOSSOPVSA-N	243000	US9422277, 63	Beta-secretase 2		 527.3						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243000&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774751	341095138							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423967	CCCCCOc1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C22H26ClN5O4S2/c1-4-5-6-11-31-15-9-7-14(8-10-15)19-26-27-20(32-19)17-12-16(23)18(33-17)22(2)13-34(29,30)28(3)21(24)25-22/h7-10,12H,4-6,11,13H2,1-3H3,(H2,24,25)/t22-/m0/s1	LDILEPQPHIRRKQ-QFIPXVFZSA-N	243001	US9422277, 64	Beta-secretase 2		 355.8						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243001&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774752	341095139							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423968	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(c(F)c1)C(F)(F)F	InChI=1S/C18H14ClF4N5O3S2/c1-17(7-33(29,30)28(2)16(24)25-17)13-10(19)6-12(32-13)15-27-26-14(31-15)8-3-4-9(11(20)5-8)18(21,22)23/h3-6H,7H2,1-2H3,(H2,24,25)/t17-/m0/s1	YVUYMMPPOKWTGQ-KRWDZBQOSA-N	243002	US9422277, 65	Beta-secretase 2		 366.2						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243002&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774888	341095140							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423969	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)C1(COC1)C#N	InChI=1S/C21H19ClN6O4S2/c1-20(11-34(29,30)28(2)19(24)25-20)16-14(22)7-15(33-16)18-27-26-17(32-18)12-3-5-13(6-4-12)21(8-23)9-31-10-21/h3-7H,9-11H2,1-2H3,(H2,24,25)/t20-/m0/s1	DSOROAFTBZZSKC-FQEVSTJZSA-N	243003	US9422277, 66	Beta-secretase 2		 1070						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243003&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774889	341095141							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423970	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)C1CCC(F)(F)C1	InChI=1S/C22H22ClF2N5O3S2/c1-21(11-35(31,32)30(2)20(26)27-21)17-15(23)9-16(34-17)19-29-28-18(33-19)13-5-3-12(4-6-13)14-7-8-22(24,25)10-14/h3-6,9,14H,7-8,10-11H2,1-2H3,(H2,26,27)/t14?,21-/m0/s1	WVMOEAAQDAAEBM-YNNZGITBSA-N	243004	US9422277, 67	Beta-secretase 2		 1866						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243004&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774890	341095142							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423971	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)N1CCCCC1	InChI=1S/C22H25ClN6O3S2/c1-22(13-34(30,31)28(2)21(24)25-22)18-16(23)12-17(33-18)20-27-26-19(32-20)14-6-8-15(9-7-14)29-10-4-3-5-11-29/h6-9,12H,3-5,10-11,13H2,1-2H3,(H2,24,25)/t22-/m0/s1	AEYDNTDXIXLOBT-QFIPXVFZSA-N	243005	US9422277, 68	Beta-secretase 2		 2992						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243005&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774891	341095143							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423972	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)N1CCCC1=O	InChI=1S/C21H21ClN6O4S2/c1-21(11-34(30,31)27(2)20(23)24-21)17-14(22)10-15(33-17)19-26-25-18(32-19)12-5-7-13(8-6-12)28-9-3-4-16(28)29/h5-8,10H,3-4,9,11H2,1-2H3,(H2,23,24)/t21-/m0/s1	GJCYRUCRPPSGON-NRFANRHFSA-N	243006	US9422277, 69	Beta-secretase 2		 1070						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243006&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73774892	341095144							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423973	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)-n1cnnn1	InChI=1S/C18H16ClN9O3S2/c1-18(8-33(29,30)27(2)17(20)22-18)14-12(19)7-13(32-14)16-24-23-15(31-16)10-3-5-11(6-4-10)28-9-21-25-26-28/h3-7,9H,8H2,1-2H3,(H2,20,22)/t18-/m0/s1	REDFWSWRNJDSJK-SFHVURJKSA-N	243007	US9422277, 70	Beta-secretase 2		 1353						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243007&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775035	341095145							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423974	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)-n1cccn1	InChI=1S/C20H18ClN7O3S2/c1-20(11-33(29,30)27(2)19(22)24-20)16-14(21)10-15(32-16)18-26-25-17(31-18)12-4-6-13(7-5-12)28-9-3-8-23-28/h3-10H,11H2,1-2H3,(H2,22,24)/t20-/m0/s1	MSDKNBBSDUWPBS-FQEVSTJZSA-N	243008	US9422277, 71	Beta-secretase 2		 181.2						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243008&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118406556	341095146							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423975	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc2sc(C)nc2c1	InChI=1S/C19H17ClN6O3S3/c1-9-22-12-6-10(4-5-13(12)30-9)16-24-25-17(29-16)14-7-11(20)15(31-14)19(2)8-32(27,28)26(3)18(21)23-19/h4-7H,8H2,1-3H3,(H2,21,23)/t19-/m0/s1	CBXDMVDHUBWAMC-IBGZPJMESA-N	243009	US9422277, 72	Beta-secretase 2		 1154						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243009&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775036	341095147							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423976	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc2scnc2c1	InChI=1S/C18H15ClN6O3S3/c1-18(7-31(26,27)25(2)17(20)22-18)14-10(19)6-13(30-14)16-24-23-15(28-16)9-3-4-12-11(5-9)21-8-29-12/h3-6,8H,7H2,1-2H3,(H2,20,22)/t18-/m0/s1	NFXILRMLYYFVFN-SFHVURJKSA-N	243010	US9422277, 73	Beta-secretase 2		 336						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243010&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775037	341095148							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423977	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc2CCC(=O)c2c1	InChI=1S/C20H18ClN5O4S2/c1-20(9-32(28,29)26(2)19(22)23-20)16-13(21)8-15(31-16)18-25-24-17(30-18)11-4-3-10-5-6-14(27)12(10)7-11/h3-4,7-8H,5-6,9H2,1-2H3,(H2,22,23)/t20-/m0/s1	YLFTYITZAISXSL-FQEVSTJZSA-N	243011	US9422277, 74	Beta-secretase 2		 1994						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243011&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775038	341095149							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423978	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cn1)C(F)(F)F	InChI=1S/C17H14ClF3N6O3S2/c1-16(7-32(28,29)27(2)15(22)24-16)12-9(18)5-11(31-12)14-26-25-13(30-14)10-4-3-8(6-23-10)17(19,20)21/h3-6H,7H2,1-2H3,(H2,22,24)/t16-/m0/s1	SMSPJNIMZPNYEZ-INIZCTEOSA-N	243012	US9422277, 75	Beta-secretase 2		 303.4						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243012&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775039	341095150							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423979	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)-c1ccon1	InChI=1S/C20H17ClN6O4S2/c1-20(10-33(28,29)27(2)19(22)23-20)16-13(21)9-15(32-16)18-25-24-17(31-18)12-5-3-11(4-6-12)14-7-8-30-26-14/h3-9H,10H2,1-2H3,(H2,22,23)/t20-/m0/s1	KXJAAHGJNPSZTB-FQEVSTJZSA-N	243013	US9422277, 76	Beta-secretase 2		 242.7						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243013&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775198	341095151							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423980	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(cc1)-c1noc(n1)C(F)(F)F	InChI=1S/C20H15ClF3N7O4S2/c1-19(8-37(32,33)31(2)18(25)27-19)13-11(21)7-12(36-13)16-29-28-15(34-16)10-5-3-9(4-6-10)14-26-17(35-30-14)20(22,23)24/h3-7H,8H2,1-2H3,(H2,25,27)/t19-/m0/s1	XCXIXBDAZAPGRB-IBGZPJMESA-N	243014	US9422277, 77	Beta-secretase 2		 1279						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243014&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775199	341095152							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423981	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(OC(F)(F)F)cc1	InChI=1S/C18H15ClF3N5O4S2/c1-17(8-33(28,29)27(2)16(23)24-17)13-11(19)7-12(32-13)15-26-25-14(30-15)9-3-5-10(6-4-9)31-18(20,21)22/h3-7H,8H2,1-2H3,(H2,23,24)/t17-/m0/s1	DAJJCBMNFMZRNY-KRWDZBQOSA-N	243015	US9422277, 78	Beta-secretase 2		 143.2						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243015&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775200	341095153							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423982	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(OC(F)F)cc1	InChI=1S/C18H16ClF2N5O4S2/c1-18(8-32(27,28)26(2)17(22)23-18)13-11(19)7-12(31-13)15-25-24-14(30-15)9-3-5-10(6-4-9)29-16(20)21/h3-7,16H,8H2,1-2H3,(H2,22,23)/t18-/m0/s1	MESPFPNZSZWKSJ-SFHVURJKSA-N	243016	US9422277, 79	Beta-secretase 2		 131.8						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243016&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775201	341095154							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423983	COC(=O)Cc1ccc(cc1)-c1nnc(o1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C20H20ClN5O5S2/c1-20(10-33(28,29)26(2)19(22)23-20)16-13(21)9-14(32-16)18-25-24-17(31-18)12-6-4-11(5-7-12)8-15(27)30-3/h4-7,9H,8,10H2,1-3H3,(H2,22,23)/t20-/m0/s1	BEOYHDWAKQPMOO-FQEVSTJZSA-N	243017	US9422277, 80	Beta-secretase 2		 671.2						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243017&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775202	341095155							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423984	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1cnn(c1)-c1ccccc1	InChI=1S/C22H20FN5O2S2/c1-22(13-32(29,30)27(2)21(24)26-22)20-18(23)17-10-6-9-16(19(17)31-20)14-11-25-28(12-14)15-7-4-3-5-8-15/h3-12H,13H2,1-2H3,(H2,24,26)/t22-/m0/s1	CQSZGMNRQOHLML-QFIPXVFZSA-N	243018	US9422277, 81	Beta-secretase 2		 337						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243018	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243018&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775352	341095156							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423985	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1coc(n1)-c1ccc(F)cc1	InChI=1S/C22H18F2N4O3S2/c1-22(11-33(29,30)28(2)21(25)27-22)19-17(24)15-5-3-4-14(18(15)32-19)16-10-31-20(26-16)12-6-8-13(23)9-7-12/h3-10H,11H2,1-2H3,(H2,25,27)/t22-/m0/s1	HAFFQZUPNWJFBP-QFIPXVFZSA-N	243019	US9422277, 82	Beta-secretase 2		 2943						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243019&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775353	341095157							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423986	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1cnc(o1)-c1ccc(F)cc1	InChI=1S/C22H18F2N4O3S2/c1-22(11-33(29,30)28(2)21(25)27-22)19-17(24)15-5-3-4-14(18(15)32-19)16-10-26-20(31-16)12-6-8-13(23)9-7-12/h3-10H,11H2,1-2H3,(H2,25,27)/t22-/m0/s1	UYXCWSFFJWWPIB-QFIPXVFZSA-N	243020	US9422277, 83	Beta-secretase 2		 3315						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243020&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775354	341095158							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423987	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(F)cc1	InChI=1S/C17H15ClFN5O3S2/c1-17(8-29(25,26)24(2)16(20)21-17)13-11(18)7-12(28-13)15-23-22-14(27-15)9-3-5-10(19)6-4-9/h3-7H,8H2,1-2H3,(H2,20,21)/t17-/m0/s1	GHVBKTVASKIYHA-KRWDZBQOSA-N	242959	US9422277, 22::US9422277, 84	Beta-secretase 2		 10.64						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242959&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73776019	341095097							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
423988	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cnn(c1)-c1ccccc1	InChI=1S/C18H18ClN5O2S2/c1-18(11-28(25,26)23(2)17(20)22-18)16-14(19)8-15(27-16)12-9-21-24(10-12)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H2,20,22)/t18-/m0/s1	XKLYFNQUOQRSQC-SFHVURJKSA-N	243022	US9422277, 85	Beta-secretase 2		 27.87						5	30.00 C	US Patent		10.7270/Q2VX0FFW		aid1803308	US9422277	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=243022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=243022&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775351	341095159							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422472	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C17H16ClN5O3S2/c1-17(8-28(24,25)23(2)16(19)21-17)14-12(18)7-13(27-14)10-4-3-5-11(6-10)15-22-20-9-26-15/h3-7,9H,8H2,1-2H3,(H2,19,21)/t17-/m0/s1	BAAHXMJZFXGBDB-KRWDZBQOSA-N	242223	US9416129, 1	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222343	341094476							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422473	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1nnco1	InChI=1S/C17H16FN5O3S2/c1-17(8-28(24,25)23(2)16(19)21-17)14-12(18)7-13(27-14)10-4-3-5-11(6-10)15-22-20-9-26-15/h3-7,9H,8H2,1-2H3,(H2,19,21)/t17-/m0/s1	NOJNOEDQKNRCDF-KRWDZBQOSA-N	242224	US9416129, 2	Beta-secretase 2		 13.8						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242224&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222344	341094477							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422474	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cncc(c1)-c1nnco1	InChI=1S/C16H15FN6O3S2/c1-16(7-28(24,25)23(2)15(18)21-16)13-11(17)4-12(27-13)9-3-10(6-19-5-9)14-22-20-8-26-14/h3-6,8H,7H2,1-2H3,(H2,18,21)/t16-/m0/s1	PAXNTSLCJPOLCT-INIZCTEOSA-N	242225	US9416129, 3::US9416129, 5	Beta-secretase 2		 25.9						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242225&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222418	341094478							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422475	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1cc[nH]n1			242226	US9416129, 4	Beta-secretase 2		 0.35						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242226&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222419	341094479							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422476	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cncc(c1)-c1nnco1	InChI=1S/C16H15FN6O3S2/c1-16(7-28(24,25)23(2)15(18)21-16)13-11(17)4-12(27-13)9-3-10(6-19-5-9)14-22-20-8-26-14/h3-6,8H,7H2,1-2H3,(H2,18,21)/t16-/m0/s1	PAXNTSLCJPOLCT-INIZCTEOSA-N	242225	US9416129, 3::US9416129, 5	Beta-secretase 2		 8.9						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242225&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222418	341094478							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422477	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1ncco1	InChI=1S/C18H17ClN4O3S2/c1-18(10-28(24,25)23(2)17(20)22-18)15-13(19)9-14(27-15)11-4-3-5-12(8-11)16-21-6-7-26-16/h3-9H,10H2,1-2H3,(H2,20,22)/t18-/m0/s1	AQBYGTNMCAHIJI-SFHVURJKSA-N	242228	US9416129, 6	Beta-secretase 2		 1.4						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222421	341094480							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422478	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1ncco1	InChI=1S/C18H17FN4O3S2/c1-18(10-28(24,25)23(2)17(20)22-18)15-13(19)9-14(27-15)11-4-3-5-12(8-11)16-21-6-7-26-16/h3-9H,10H2,1-2H3,(H2,20,22)/t18-/m0/s1	RDFXNEIPFIKQQK-SFHVURJKSA-N	242229	US9416129, 7	Beta-secretase 2		 0.73						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222422	341094481							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422479	CN1\C(N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1cccc(c1)-c1ncco1)=N/C(=O)OC(C)(C)C	InChI=1S/C25H27FN4O5S/c1-24(2,3)35-23(31)28-22-29-25(4,15-36(32,33)30(22)5)19-14-17(9-10-20(19)26)16-7-6-8-18(13-16)21-27-11-12-34-21/h6-14H,15H2,1-5H3,(H,28,29,31)/t25-/m0/s1	LHLOZNPQSYUQGI-VWLOTQADSA-N	242230	US9416129, 8	Beta-secretase 2		 219						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242230&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424749	341094482							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422480	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cncc(c1)-c1ncco1	InChI=1S/C17H16ClN5O3S2/c1-17(9-28(24,25)23(2)16(19)22-17)14-12(18)6-13(27-14)10-5-11(8-20-7-10)15-21-3-4-26-15/h3-8H,9H2,1-2H3,(H2,19,22)/t17-/m0/s1	QKWBNNWMPUSPAD-KRWDZBQOSA-N	242231	US9416129, 9	Beta-secretase 2		 0.31						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242231&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222423	341094483							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422481	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cncc(c1)-c1ncco1	InChI=1S/C17H16FN5O3S2/c1-17(9-28(24,25)23(2)16(19)22-17)14-12(18)6-13(27-14)10-5-11(8-20-7-10)15-21-3-4-26-15/h3-8H,9H2,1-2H3,(H2,19,22)/t17-/m0/s1	BTJBTQGKHJJQHK-KRWDZBQOSA-N	242232	US9416129, 10	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242232&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424750	341094484							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422482	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1cnco1	InChI=1S/C18H17ClN4O3S2/c1-18(9-28(24,25)23(2)17(20)22-18)16-13(19)7-15(27-16)12-5-3-4-11(6-12)14-8-21-10-26-14/h3-8,10H,9H2,1-2H3,(H2,20,22)/t18-/m0/s1	XPQWYRWKVVGNSH-SFHVURJKSA-N	242233	US9416129, 11	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242233&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222503	341094485							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422483	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1cnco1	InChI=1S/C18H17FN4O3S2/c1-18(9-28(24,25)23(2)17(20)22-18)16-13(19)7-15(27-16)12-5-3-4-11(6-12)14-8-21-10-26-14/h3-8,10H,9H2,1-2H3,(H2,20,22)/t18-/m0/s1	BCZYTSLTMCVOAL-SFHVURJKSA-N	242234	US9416129, 12	Beta-secretase 2		 3.7						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242234&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222504	341094486							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422484	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1ccno1	InChI=1S/C18H17ClN4O3S2/c1-18(10-28(24,25)23(2)17(20)22-18)16-13(19)9-15(27-16)12-5-3-4-11(8-12)14-6-7-21-26-14/h3-9H,10H2,1-2H3,(H2,20,22)/t18-/m0/s1	PGOFVLPJWBFJQT-SFHVURJKSA-N	242235	US9416129, 13	Beta-secretase 2		 2.4						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222505	341094487							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422485	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1ccno1	InChI=1S/C18H17FN4O3S2/c1-18(10-28(24,25)23(2)17(20)22-18)16-13(19)9-15(27-16)12-5-3-4-11(8-12)14-6-7-21-26-14/h3-9H,10H2,1-2H3,(H2,20,22)/t18-/m0/s1	NIHHKLBZWLPJSH-SFHVURJKSA-N	242236	US9416129, 14	Beta-secretase 2		 3.5						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242236&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222506	341094488							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422486	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nnc(C)o1	InChI=1S/C18H18ClN5O3S2/c1-10-22-23-16(27-10)12-6-4-5-11(7-12)14-8-13(19)15(28-14)18(2)9-29(25,26)24(3)17(20)21-18/h4-8H,9H2,1-3H3,(H2,20,21)/t18-/m0/s1	UAQNMLNBXRBMEC-SFHVURJKSA-N	242237	US9416129, 15::US9416129, 53	Beta-secretase 2		 3.8						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222507	341094489							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422487	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1nnc(C)o1	InChI=1S/C18H18FN5O3S2/c1-10-22-23-16(27-10)12-6-4-5-11(7-12)14-8-13(19)15(28-14)18(2)9-29(25,26)24(3)17(20)21-18/h4-8H,9H2,1-3H3,(H2,20,21)/t18-/m0/s1	JGWGDWAPGDPQBM-SFHVURJKSA-N	242238	US9416129, 16	Beta-secretase 2		 4.2						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242238&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222508	341094490							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422488	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nnc(o1)C1CC1	InChI=1S/C20H20ClN5O3S2/c1-20(10-31(27,28)26(2)19(22)23-20)16-14(21)9-15(30-16)12-4-3-5-13(8-12)18-25-24-17(29-18)11-6-7-11/h3-5,8-9,11H,6-7,10H2,1-2H3,(H2,22,23)/t20-/m0/s1	ZHIDWPGYBWTWTM-FQEVSTJZSA-N	242239	US9416129, 17	Beta-secretase 2		 2.2						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242239&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222593	341094491							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422489	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1nnc(o1)C1CC1	InChI=1S/C20H20FN5O3S2/c1-20(10-31(27,28)26(2)19(22)23-20)16-14(21)9-15(30-16)12-4-3-5-13(8-12)18-25-24-17(29-18)11-6-7-11/h3-5,8-9,11H,6-7,10H2,1-2H3,(H2,22,23)/t20-/m0/s1	GEEDGUFXLZCPST-FQEVSTJZSA-N	242240	US9416129, 18	Beta-secretase 2		 4.2						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242240&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222594	341094492							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422490	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(cs1)-c1cccc(c1)-c1nnco1	InChI=1S/C17H17N5O3S2/c1-17(9-27(23,24)22(2)16(18)20-17)14-7-13(8-26-14)11-4-3-5-12(6-11)15-21-19-10-25-15/h3-8,10H,9H2,1-2H3,(H2,18,20)/t17-/m0/s1	AHQBEGBCTMLPIL-KRWDZBQOSA-N	242241	US9416129, 19	Beta-secretase 2		 52						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222595	341094493							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422491	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cncc(c1)-c1cnco1	InChI=1S/C17H16ClN5O3S2/c1-17(8-28(24,25)23(2)16(19)22-17)15-12(18)4-14(27-15)11-3-10(5-20-6-11)13-7-21-9-26-13/h3-7,9H,8H2,1-2H3,(H2,19,22)/t17-/m0/s1	GBNVHSMWQKWIRA-KRWDZBQOSA-N	242242	US9416129, 20	Beta-secretase 2		 8.9						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242242&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222596	341094494							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422492	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cncc(c1)-c1cnco1	InChI=1S/C17H16FN5O3S2/c1-17(8-28(24,25)23(2)16(19)22-17)15-12(18)4-14(27-15)11-3-10(5-20-6-11)13-7-21-9-26-13/h3-7,9H,8H2,1-2H3,(H2,19,22)/t17-/m0/s1	PUDHZBQAIHLCGW-KRWDZBQOSA-N	242243	US9416129, 21	Beta-secretase 2		 16						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242243&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222597	341094495							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422493	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(cs1)-c1cncc(c1)-c1cnco1	InChI=1S/C17H17N5O3S2/c1-17(9-27(23,24)22(2)16(18)21-17)15-4-13(8-26-15)11-3-12(6-19-5-11)14-7-20-10-25-14/h3-8,10H,9H2,1-2H3,(H2,18,21)/t17-/m0/s1	YNYYSRGLRMOFMG-KRWDZBQOSA-N	242244	US9416129, 22	Beta-secretase 2		 98						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242244&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424751	341094496							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422494	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cc(F)cc(c1)-c1cnco1	InChI=1S/C18H16ClFN4O3S2/c1-18(8-29(25,26)24(2)17(21)23-18)16-13(19)6-15(28-16)11-3-10(4-12(20)5-11)14-7-22-9-27-14/h3-7,9H,8H2,1-2H3,(H2,21,23)/t18-/m0/s1	GHBMDYDTNUNLGX-SFHVURJKSA-N	242245	US9416129, 23	Beta-secretase 2		 4.8						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242245&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222598	341094497							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422495	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(cs1)-c1cc(F)cc(c1)-c1cnco1	InChI=1S/C18H17FN4O3S2/c1-18(9-28(24,25)23(2)17(20)22-18)16-6-13(8-27-16)11-3-12(5-14(19)4-11)15-7-21-10-26-15/h3-8,10H,9H2,1-2H3,(H2,20,22)/t18-/m0/s1	ZKFJFCCWVBATAJ-SFHVURJKSA-N	242246	US9416129, 24	Beta-secretase 2		 18						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424752	341094498							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422496	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cc(F)cc(c1)-c1cnco1	InChI=1S/C18H16F2N4O3S2/c1-18(8-29(25,26)24(2)17(21)23-18)16-13(20)6-15(28-16)11-3-10(4-12(19)5-11)14-7-22-9-27-14/h3-7,9H,8H2,1-2H3,(H2,21,23)/t18-/m0/s1	NJUKYCIWZOWFFT-SFHVURJKSA-N	242247	US9416129, 25	Beta-secretase 2		 4.8						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222679	341094499							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422497	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1ncc(s1)-c1cccc(c1)-c1ncco1	InChI=1S/C17H17N5O3S2/c1-17(10-27(23,24)22(2)16(18)21-17)15-20-9-13(26-15)11-4-3-5-12(8-11)14-19-6-7-25-14/h3-9H,10H2,1-2H3,(H2,18,21)/t17-/m0/s1	JTZAKJMCPMMAFY-KRWDZBQOSA-N	242248	US9416129, 26	Beta-secretase 2		 5.7						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222680	341094500							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422498	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1ncc(s1)-c1cccc(c1)-c1nnco1	InChI=1S/C16H16N6O3S2/c1-16(8-27(23,24)22(2)15(17)20-16)14-18-7-12(26-14)10-4-3-5-11(6-10)13-21-19-9-25-13/h3-7,9H,8H2,1-2H3,(H2,17,20)/t16-/m0/s1	ZOFZMRNFUHUFBV-INIZCTEOSA-N	242249	US9416129, 27	Beta-secretase 2		 152						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242249&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222681	341094501							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422499	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C17H15ClFN5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-12(18)6-13(28-14)9-3-10(5-11(19)4-9)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	VPGJWPAEKCQKMY-KRWDZBQOSA-N	242250	US9416129, 28	Beta-secretase 2		 0.28						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222683	341094502							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422500	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C17H15F2N5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-12(19)6-13(28-14)9-3-10(5-11(18)4-9)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	GSXNFTYLLVDBEE-KRWDZBQOSA-N	242251	US9416129, 29	Beta-secretase 2		 1.3						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242251&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222684	341094503							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422501	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C19H17F2N5O3S/c1-19(9-30(27,28)26(2)18(22)24-19)15-8-11(3-4-16(15)21)12-5-13(7-14(20)6-12)17-25-23-10-29-17/h3-8,10H,9H2,1-2H3,(H2,22,24)/t19-/m0/s1	HQCCFVZUESJNIO-IBGZPJMESA-N	242252	US9416129, 30	Beta-secretase 2		 235						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242252&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424753	341094504							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422502	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cc(ccc1F)-c1nnco1	InChI=1S/C17H15ClFN5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-11(18)6-13(28-14)10-5-9(3-4-12(10)19)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	CNJVSRRJLACLOU-KRWDZBQOSA-N	242253	US9416129, 31	Beta-secretase 2		 4.2						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222767	341094505							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422503	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cc(ccc1F)-c1nnco1	InChI=1S/C17H15F2N5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-12(19)6-13(28-14)10-5-9(3-4-11(10)18)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	VJNUVDOJKFVXPP-KRWDZBQOSA-N	242254	US9416129, 32	Beta-secretase 2		 3.9						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222766	341094506							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422504	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(F)c(c1)-c1nnco1	InChI=1S/C17H15ClFN5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-11(18)6-13(28-14)9-3-4-12(19)10(5-9)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	UKDMICDMAJRMJA-KRWDZBQOSA-N	242255	US9416129, 33	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242255&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222768	341094507							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422505	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccc(F)c(c1)-c1nnco1	InChI=1S/C17H15F2N5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-12(19)6-13(28-14)9-3-4-11(18)10(5-9)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	UKNDORQOFAUISA-KRWDZBQOSA-N	242256	US9416129, 34	Beta-secretase 2		 11						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222769	341094508							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422506	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(-c2nnco2)c1F	InChI=1S/C17H15ClFN5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-11(18)6-12(28-14)9-4-3-5-10(13(9)19)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	FOSTZFFYNMXFJE-KRWDZBQOSA-N	242257	US9416129, 35	Beta-secretase 2		 30						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222771	341094509							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422507	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(-c2nnco2)c1F	InChI=1S/C17H15F2N5O3S2/c1-17(7-29(25,26)24(2)16(20)22-17)14-11(18)6-12(28-14)9-4-3-5-10(13(9)19)15-23-21-8-27-15/h3-6,8H,7H2,1-2H3,(H2,20,22)/t17-/m0/s1	OMTGTKWXQOFYJU-KRWDZBQOSA-N	242258	US9416129, 36	Beta-secretase 2		 247						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242258&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222770	341094510							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422508	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nc(C)no1	InChI=1S/C18H18ClN5O3S2/c1-10-21-16(27-23-10)12-6-4-5-11(7-12)14-8-13(19)15(28-14)18(2)9-29(25,26)24(3)17(20)22-18/h4-8H,9H2,1-3H3,(H2,20,22)/t18-/m0/s1	JCZLEDOQKVCZLO-SFHVURJKSA-N	242259	US9416129, 37	Beta-secretase 2		 4.6						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242259&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222859	341094511							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422509	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1nc(C)no1	InChI=1S/C18H18FN5O3S2/c1-10-21-16(27-23-10)12-6-4-5-11(7-12)14-8-13(19)15(28-14)18(2)9-29(25,26)24(3)17(20)22-18/h4-8H,9H2,1-3H3,(H2,20,22)/t18-/m0/s1	NWHFUPWENCEKPO-SFHVURJKSA-N	242260	US9416129, 38	Beta-secretase 2		 3.6						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242260&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222860	341094512							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422510	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1nc(no1)C1CC1	InChI=1S/C20H20ClN5O3S2/c1-20(10-31(27,28)26(2)19(22)24-20)16-14(21)9-15(30-16)12-4-3-5-13(8-12)18-23-17(25-29-18)11-6-7-11/h3-5,8-9,11H,6-7,10H2,1-2H3,(H2,22,24)/t20-/m0/s1	GLKUVEVVTQAQSO-FQEVSTJZSA-N	242261	US9416129, 39	Beta-secretase 2		 9.9						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222862	341094513							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422511	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1nc(no1)C1CC1	InChI=1S/C20H20FN5O3S2/c1-20(10-31(27,28)26(2)19(22)24-20)16-14(21)9-15(30-16)12-4-3-5-13(8-12)18-23-17(25-29-18)11-6-7-11/h3-5,8-9,11H,6-7,10H2,1-2H3,(H2,22,24)/t20-/m0/s1	XDXZXIYBULROAC-FQEVSTJZSA-N	242262	US9416129, 40	Beta-secretase 2		 9.5						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222861	341094514							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422512	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1noc(C)n1	InChI=1S/C18H18ClN5O3S2/c1-10-21-16(23-27-10)12-6-4-5-11(7-12)14-8-13(19)15(28-14)18(2)9-29(25,26)24(3)17(20)22-18/h4-8H,9H2,1-3H3,(H2,20,22)/t18-/m0/s1	PFPLPKXWOLCFDK-SFHVURJKSA-N	242263	US9416129, 41	Beta-secretase 2		 0.35						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242263&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222863	341094515							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422513	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1noc(C)n1	InChI=1S/C18H18FN5O3S2/c1-10-21-16(23-27-10)12-6-4-5-11(7-12)14-8-13(19)15(28-14)18(2)9-29(25,26)24(3)17(20)22-18/h4-8H,9H2,1-3H3,(H2,20,22)/t18-/m0/s1	PKJIPWSDUYMKAI-SFHVURJKSA-N	242264	US9416129, 42	Beta-secretase 2		 1.1						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222864	341094516							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422514	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(cs1)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C17H16FN5O3S2/c1-17(8-28(24,25)23(2)16(19)21-17)14-6-12(7-27-14)10-3-11(5-13(18)4-10)15-22-20-9-26-15/h3-7,9H,8H2,1-2H3,(H2,19,21)/t17-/m0/s1	SCIVGAXEUFNCTL-KRWDZBQOSA-N	242265	US9416129, 43	Beta-secretase 2		 6.5						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242265&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424754	341094517							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422515	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1noc(n1)C1CC1	InChI=1S/C20H20ClN5O3S2/c1-20(10-31(27,28)26(2)19(22)24-20)16-14(21)9-15(30-16)12-4-3-5-13(8-12)17-23-18(29-25-17)11-6-7-11/h3-5,8-9,11H,6-7,10H2,1-2H3,(H2,22,24)/t20-/m0/s1	NZQWPNSLEOZOGQ-FQEVSTJZSA-N	242266	US9416129, 44	Beta-secretase 2		 0.24						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242266&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73602806	341094518							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422516	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1noc(n1)C1CC1	InChI=1S/C20H20FN5O3S2/c1-20(10-31(27,28)26(2)19(22)24-20)16-14(21)9-15(30-16)12-4-3-5-13(8-12)17-23-18(29-25-17)11-6-7-11/h3-5,8-9,11H,6-7,10H2,1-2H3,(H2,22,24)/t20-/m0/s1	JWDKUOVVZFZGNU-FQEVSTJZSA-N	242267	US9416129, 45	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242267&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222954	341094519							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422517	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1ncon1	InChI=1S/C17H16ClN5O3S2/c1-17(8-28(24,25)23(2)16(19)21-17)14-12(18)7-13(27-14)10-4-3-5-11(6-10)15-20-9-26-22-15/h3-7,9H,8H2,1-2H3,(H2,19,21)/t17-/m0/s1	FTHWKRFIPDQNGI-KRWDZBQOSA-N	242268	US9416129, 46	Beta-secretase 2		 0.41						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242268&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222955	341094520							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422518	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1ncon1	InChI=1S/C17H16FN5O3S2/c1-17(8-28(24,25)23(2)16(19)21-17)14-12(18)7-13(27-14)10-4-3-5-11(6-10)15-20-9-26-22-15/h3-7,9H,8H2,1-2H3,(H2,19,21)/t17-/m0/s1	GGCKFWXYKBJBSD-KRWDZBQOSA-N	242269	US9416129, 47	Beta-secretase 2		 0.34						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242269&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222956	341094521							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422519	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cccc(c1)-c1ncno1	InChI=1S/C17H16FN5O3S2/c1-17(8-28(24,25)23(2)16(19)22-17)14-12(18)7-13(27-14)10-4-3-5-11(6-10)15-20-9-21-26-15/h3-7,9H,8H2,1-2H3,(H2,19,22)/t17-/m0/s1	RNFDJIKFQXXGSS-KRWDZBQOSA-N	242270	US9416129, 48	Beta-secretase 2		 0.63						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242270&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424755	341094522							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422520	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccnc(c1)-c1nc(C)no1	InChI=1S/C17H17ClN6O3S2/c1-9-21-15(27-23-9)12-6-10(4-5-20-12)13-7-11(18)14(28-13)17(2)8-29(25,26)24(3)16(19)22-17/h4-7H,8H2,1-3H3,(H2,19,22)/t17-/m0/s1	JNGKMRMVYPULQW-KRWDZBQOSA-N	242271	US9416129, 49	Beta-secretase 2		 1.1						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242271&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424756	341094523							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422521	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-c1nc(C)no1	InChI=1S/C17H17FN6O3S2/c1-9-21-15(27-23-9)12-6-10(4-5-20-12)13-7-11(18)14(28-13)17(2)8-29(25,26)24(3)16(19)22-17/h4-7H,8H2,1-3H3,(H2,19,22)/t17-/m0/s1	QKWAZHOWCCPSFB-KRWDZBQOSA-N	242272	US9416129, 50	Beta-secretase 2		 2.3						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242272	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242272&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424757	341094524							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422522	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccnc(c1)-c1nc(no1)C1CC1	InChI=1S/C19H19ClN6O3S2/c1-19(9-31(27,28)26(2)18(21)24-19)15-12(20)8-14(30-15)11-5-6-22-13(7-11)17-23-16(25-29-17)10-3-4-10/h5-8,10H,3-4,9H2,1-2H3,(H2,21,24)/t19-/m0/s1	HVSSLODCZRTLNA-IBGZPJMESA-N	242273	US9416129, 51	Beta-secretase 2		 2.5						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242273	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242273&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222957	341094525							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422523	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-c1nc(no1)C1CC1	InChI=1S/C19H19FN6O3S2/c1-19(9-31(27,28)26(2)18(21)24-19)15-12(20)8-14(30-15)11-5-6-22-13(7-11)17-23-16(25-29-17)10-3-4-10/h5-8,10H,3-4,9H2,1-2H3,(H2,21,24)/t19-/m0/s1	RRLFWRMMWTVJOL-IBGZPJMESA-N	242274	US9416129, 52	Beta-secretase 2		 17						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242274	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242274&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222958	341094526							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422524	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-c1ccccc1	InChI=1S/C20H19FN4O2S2/c1-20(12-29(26,27)25(2)19(22)24-20)18-15(21)11-17(28-18)14-8-9-23-16(10-14)13-6-4-3-5-7-13/h3-11H,12H2,1-2H3,(H2,22,24)/t20-/m0/s1	OUOVRDXFJWCQLN-FQEVSTJZSA-N	242276	US9416129, 54	Beta-secretase 2		 12						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242276	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242276&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221646	341094527							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422525	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-c1cncnc1	InChI=1S/C18H17FN6O2S2/c1-18(9-29(26,27)25(2)17(20)24-18)16-13(19)6-15(28-16)11-3-4-23-14(5-11)12-7-21-10-22-8-12/h3-8,10H,9H2,1-2H3,(H2,20,24)/t18-/m0/s1	ILCUCDCMDXGEQH-SFHVURJKSA-N	242277	US9416129, 55	Beta-secretase 2		 212						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242277	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242277&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221647	341094528							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422526	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-c1cnco1	InChI=1S/C17H16FN5O3S2/c1-17(8-28(24,25)23(2)16(19)22-17)15-11(18)6-14(27-15)10-3-4-21-12(5-10)13-7-20-9-26-13/h3-7,9H,8H2,1-2H3,(H2,19,22)/t17-/m0/s1	ZRFQYHXYMAYWRA-KRWDZBQOSA-N	242278	US9416129, 56	Beta-secretase 2		 20						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242278	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242278&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222959	341094529							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422527	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cncc(c1)-c1nnc(o1)C1CC1	InChI=1S/C19H19ClN6O3S2/c1-19(9-31(27,28)26(2)18(21)23-19)15-13(20)6-14(30-15)11-5-12(8-22-7-11)17-25-24-16(29-17)10-3-4-10/h5-8,10H,3-4,9H2,1-2H3,(H2,21,23)/t19-/m0/s1	AAXNGXBJBIQTNE-IBGZPJMESA-N	242279	US9416129, 57	Beta-secretase 2		 44						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242279	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242279&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424763	341094530							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422528	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cc(ncc1F)-c1nnco1	InChI=1S/C16H14ClFN6O3S2/c1-16(6-29(25,26)24(2)15(19)22-16)13-9(17)4-12(28-13)8-3-11(20-5-10(8)18)14-23-21-7-27-14/h3-5,7H,6H2,1-2H3,(H2,19,22)/t16-/m0/s1	IUACEMFFTQYZCX-INIZCTEOSA-N	242280	US9416129, 58	Beta-secretase 2		 66						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242280	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242280&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424760	341094531							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422529	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1cc(ncc1F)-c1nnco1	InChI=1S/C16H14F2N6O3S2/c1-16(6-29(25,26)24(2)15(19)22-16)13-9(17)4-12(28-13)8-3-11(20-5-10(8)18)14-23-21-7-27-14/h3-5,7H,6H2,1-2H3,(H2,19,22)/t16-/m0/s1	XBQWDFCCZDPOMK-INIZCTEOSA-N	242281	US9416129, 59	Beta-secretase 2		 92						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242281	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242281&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424762	341094532							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422530	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-n1cccn1	InChI=1S/C18H18ClN5O2S2/c1-18(11-28(25,26)23(2)17(20)22-18)16-14(19)10-15(27-16)12-5-3-6-13(9-12)24-8-4-7-21-24/h3-10H,11H2,1-2H3,(H2,20,22)/t18-/m0/s1	ZDSCTCSNPPYHDT-SFHVURJKSA-N	242282	US9416129, 60	Beta-secretase 2		 1.6						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242282	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242282&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221740	341094533							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422531	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)N1CCS(=O)(=O)CC1	InChI=1S/C19H23ClN4O4S3/c1-19(12-31(27,28)23(2)18(21)22-19)17-15(20)11-16(29-17)13-4-3-5-14(10-13)24-6-8-30(25,26)9-7-24/h3-5,10-11H,6-9,12H2,1-2H3,(H2,21,22)/t19-/m0/s1	RUBJFPTUDDEZOS-IBGZPJMESA-N	242283	US9416129, 61	Beta-secretase 2		 42						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242283	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242283&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221736	341094534							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422532	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-c1ccccc1	InChI=1S/C21H20ClN3O2S2/c1-21(13-29(26,27)25(2)20(23)24-21)19-17(22)12-18(28-19)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-12H,13H2,1-2H3,(H2,23,24)/t21-/m0/s1	NVNRFSBSTBUIAJ-NRFANRHFSA-N	242284	US9416129, 62	Beta-secretase 2		 1.6						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242284&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221648	341094535							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422533	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(c1)-n1nccn1	InChI=1S/C17H17ClN6O2S2/c1-17(10-28(25,26)23(2)16(19)22-17)15-13(18)9-14(27-15)11-4-3-5-12(8-11)24-20-6-7-21-24/h3-9H,10H2,1-2H3,(H2,19,22)/t17-/m0/s1	VWLGSYUFDHSAIO-KRWDZBQOSA-N	242285	US9416129, 63	Beta-secretase 2		 4.7						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242285&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221741	341094536							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422534	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(cc1)-c1cccnc1	InChI=1S/C20H19ClN4O2S2/c1-20(12-29(26,27)25(2)19(22)24-20)18-16(21)10-17(28-18)14-7-5-13(6-8-14)15-4-3-9-23-11-15/h3-11H,12H2,1-2H3,(H2,22,24)/t20-/m0/s1	PBUAWDMRTQETMD-FQEVSTJZSA-N	242286	US9416129, 64	Beta-secretase 2		 1043						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242286&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221738	341094537							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422535	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(cc1)-c1ccccn1	InChI=1S/C20H19ClN4O2S2/c1-20(12-29(26,27)25(2)19(22)24-20)18-15(21)11-17(28-18)14-8-6-13(7-9-14)16-5-3-4-10-23-16/h3-11H,12H2,1-2H3,(H2,22,24)/t20-/m0/s1	NIPOSYUAJPNAJZ-FQEVSTJZSA-N	242287	US9416129, 65	Beta-secretase 2		 1613						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242287	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242287&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221737	341094538							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422536	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(nc1)N1CCOCC1	InChI=1S/C18H22ClN5O3S2/c1-18(11-29(25,26)23(2)17(20)22-18)16-13(19)9-14(28-16)12-3-4-15(21-10-12)24-5-7-27-8-6-24/h3-4,9-10H,5-8,11H2,1-2H3,(H2,20,22)/t18-/m0/s1	XFOUKBFQMFOWRE-SFHVURJKSA-N	242288	US9416129, 66	Beta-secretase 2		 1800						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242288	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242288&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424765	341094539							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422537	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(cc1)-n1nccn1	InChI=1S/C17H17ClN6O2S2/c1-17(10-28(25,26)23(2)16(19)22-17)15-13(18)9-14(27-15)11-3-5-12(6-4-11)24-20-7-8-21-24/h3-9H,10H2,1-2H3,(H2,19,22)/t17-/m0/s1	HNYOADSNRQLYMD-KRWDZBQOSA-N	242289	US9416129, 67	Beta-secretase 2		 555						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242289&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221826	341094540							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422538	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1cccc(n1)-n1ccnc1	InChI=1S/C17H17ClN6O2S2/c1-17(9-28(25,26)23(2)16(19)22-17)15-11(18)8-13(27-15)12-4-3-5-14(21-12)24-7-6-20-10-24/h3-8,10H,9H2,1-2H3,(H2,19,22)/t17-/m0/s1	RVJGXFQMEGVSJN-KRWDZBQOSA-N	242290	US9416129, 68	Beta-secretase 2		 77						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242290&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221825	341094541							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422539	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(cc1)-c1ncco1	InChI=1S/C18H17ClN4O3S2/c1-18(10-28(24,25)23(2)17(20)22-18)15-13(19)9-14(27-15)11-3-5-12(6-4-11)16-21-7-8-26-16/h3-9H,10H2,1-2H3,(H2,20,22)/t18-/m0/s1	RBCPBLRUOYOEQG-SFHVURJKSA-N	242291	US9416129, 69	Beta-secretase 2		 337						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242291	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242291&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221827	341094542							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422540	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(cc1)-c1nccs1	InChI=1S/C18H17ClN4O2S3/c1-18(10-28(24,25)23(2)17(20)22-18)15-13(19)9-14(27-15)11-3-5-12(6-4-11)16-21-7-8-26-16/h3-9H,10H2,1-2H3,(H2,20,22)/t18-/m0/s1	TVKYFRVIGVQDAT-SFHVURJKSA-N	242292	US9416129, 70	Beta-secretase 2		 174						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242292	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242292&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221828	341094543							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422541	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc(cc1)-n1ccnn1	InChI=1S/C17H17ClN6O2S2/c1-17(10-28(25,26)23(2)16(19)21-17)15-13(18)9-14(27-15)11-3-5-12(6-4-11)24-8-7-20-22-24/h3-9H,10H2,1-2H3,(H2,19,21)/t17-/m0/s1	VXBXRSFHVZHROG-KRWDZBQOSA-N	242293	US9416129, 71	Beta-secretase 2		 654						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242293	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242293&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221829	341094544							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422542	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-n1cnc(C)c1	InChI=1S/C18H19FN6O2S2/c1-11-8-25(10-22-11)15-6-12(4-5-21-15)14-7-13(19)16(28-14)18(2)9-29(26,27)24(3)17(20)23-18/h4-8,10H,9H2,1-3H3,(H2,20,23)/t18-/m0/s1	YTWXRLUXLLYCFX-SFHVURJKSA-N	242294	US9416129, 72	Beta-secretase 2		 26						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242294&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221830	341094545							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422543	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-c1ccncc1	InChI=1S/C19H18FN5O2S2/c1-19(11-29(26,27)25(2)18(21)24-19)17-14(20)10-16(28-17)13-5-8-23-15(9-13)12-3-6-22-7-4-12/h3-10H,11H2,1-2H3,(H2,21,24)/t19-/m0/s1	NRJDTUXBLSXRTB-IBGZPJMESA-N	242295	US9416129, 73	Beta-secretase 2		 123						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242295&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221918	341094546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422544	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-c1cccnc1	InChI=1S/C19H18FN5O2S2/c1-19(11-29(26,27)25(2)18(21)24-19)17-14(20)9-16(28-17)12-5-7-23-15(8-12)13-4-3-6-22-10-13/h3-10H,11H2,1-2H3,(H2,21,24)/t19-/m0/s1	LDWPLTDIOBMLIS-IBGZPJMESA-N	242296	US9416129, 74	Beta-secretase 2		 122						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242296	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242296&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221917	341094547							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422545	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-n1cc(C)cn1	InChI=1S/C18H19FN6O2S2/c1-11-8-22-25(9-11)15-6-12(4-5-21-15)14-7-13(19)16(28-14)18(2)10-29(26,27)24(3)17(20)23-18/h4-9H,10H2,1-3H3,(H2,20,23)/t18-/m0/s1	OJGHMQGAJTWXOQ-SFHVURJKSA-N	242297	US9416129, 75	Beta-secretase 2		 2530						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242297	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242297&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221919	341094548							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422546	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-n1ccnc1	InChI=1S/C17H17FN6O2S2/c1-17(9-28(25,26)23(2)16(19)22-17)15-12(18)8-13(27-15)11-3-4-21-14(7-11)24-6-5-20-10-24/h3-8,10H,9H2,1-2H3,(H2,19,22)/t17-/m0/s1	ZKOMWSJRSWTTJS-KRWDZBQOSA-N	242298	US9416129, 76	Beta-secretase 2		 52						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242298&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221920	341094549							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422547	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1F)-c1ccnc(c1)-n1cccn1	InChI=1S/C17H17FN6O2S2/c1-17(10-28(25,26)23(2)16(19)22-17)15-12(18)9-13(27-15)11-4-6-20-14(8-11)24-7-3-5-21-24/h3-9H,10H2,1-2H3,(H2,19,22)/t17-/m0/s1	BQNANWZRKIEKGN-KRWDZBQOSA-N	242299	US9416129, 77	Beta-secretase 2		 69						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242299	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242299&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74221921	341094550							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422548	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1cnc(nc1)C1CC1	InChI=1S/C19H19ClN6O2S2/c1-19(9-30(27,28)26(2)18(21)25-19)16-13(20)12-5-6-22-14(15(12)29-16)11-7-23-17(24-8-11)10-3-4-10/h5-8,10H,3-4,9H2,1-2H3,(H2,21,25)/t19-/m0/s1	NEHUYIDWNBEAGJ-IBGZPJMESA-N	242300	US9416129, 78	Beta-secretase 2		 23						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242300&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424766	341094551							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422549	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(nc1)C1CC1	InChI=1S/C20H20ClN5O2S2/c1-20(10-30(27,28)26(2)19(22)25-20)18-15(21)13-7-8-23-16(17(13)29-18)12-5-6-14(24-9-12)11-3-4-11/h5-9,11H,3-4,10H2,1-2H3,(H2,22,25)/t20-/m0/s1	NELPKQXZEKWLDZ-FQEVSTJZSA-N	242301	US9416129, 79	Beta-secretase 2		 22						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242301	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242301&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424768	341094552							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422550	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(nc1)-n1cccn1	InChI=1S/C20H18ClN7O2S2/c1-20(11-32(29,30)27(2)19(22)26-20)18-15(21)13-6-8-23-16(17(13)31-18)12-4-5-14(24-10-12)28-9-3-7-25-28/h3-10H,11H2,1-2H3,(H2,22,26)/t20-/m0/s1	JFKSALIFMOOXTH-FQEVSTJZSA-N	242302	US9416129, 80	Beta-secretase 2		 16						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242302	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242302&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424767	341094553							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422551	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)C1CC(=O)N1	InChI=1S/C22H21FN4O3S2/c1-22(11-32(29,30)27(2)21(24)26-22)20-18(23)15-5-3-4-14(19(15)31-20)12-6-8-13(9-7-12)16-10-17(28)25-16/h3-9,16H,10-11H2,1-2H3,(H2,24,26)(H,25,28)/t16?,22-/m0/s1	XEVRRLFIUKBQIP-XLDIYJRPSA-N	242303	US9416129, 81	Beta-secretase 2		 1715						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242303	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242303&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222009	341094554							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422552	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(nc1)-c1ccc(F)cc1F	InChI=1S/C24H19F3N4O2S2/c1-24(12-35(32,33)31(2)23(28)30-24)22-20(27)17-5-3-4-15(21(17)34-22)13-6-9-19(29-11-13)16-8-7-14(25)10-18(16)26/h3-11H,12H2,1-2H3,(H2,28,30)/t24-/m0/s1	LRAAPCFDVIUXIU-DEOSSOPVSA-N	242304	US9416129, 82	Beta-secretase 2		 61						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242304	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242304&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222007	341094555							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422553	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-n1ccnn1	InChI=1S/C21H19FN6O2S2/c1-21(12-32(29,30)27(2)20(23)25-21)19-17(22)16-5-3-4-15(18(16)31-19)13-6-8-14(9-7-13)28-11-10-24-26-28/h3-11H,12H2,1-2H3,(H2,23,25)/t21-/m0/s1	LZUVNQQZFZBFDN-NRFANRHFSA-N	242305	US9416129, 83	Beta-secretase 2		 148						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242305	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242305&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222008	341094556							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422554	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-c1ccncc1	InChI=1S/C24H21FN4O2S2/c1-24(14-33(30,31)29(2)23(26)28-24)22-20(25)19-5-3-4-18(21(19)32-22)17-8-6-15(7-9-17)16-10-12-27-13-11-16/h3-13H,14H2,1-2H3,(H2,26,28)/t24-/m0/s1	ODFLRDCKRBCMEZ-DEOSSOPVSA-N	242306	US9416129, 84	Beta-secretase 2		 764						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242306	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242306&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222096	341094557							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422555	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)N1CCS(=O)(=O)CC1	InChI=1S/C23H25FN4O4S3/c1-23(14-35(31,32)27(2)22(25)26-23)21-19(24)18-5-3-4-17(20(18)33-21)15-6-8-16(9-7-15)28-10-12-34(29,30)13-11-28/h3-9H,10-14H2,1-2H3,(H2,25,26)/t23-/m0/s1	GCRSDAGLPAGHHL-QHCPKHFHSA-N	242307	US9416129, 85	Beta-secretase 2		 4692						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242307	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242307&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222180	341094558							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422556	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-c1nccn1C	InChI=1S/C23H22FN5O2S2/c1-23(13-33(30,31)29(3)22(25)27-23)20-18(24)17-6-4-5-16(19(17)32-20)14-7-9-15(10-8-14)21-26-11-12-28(21)2/h4-12H,13H2,1-3H3,(H2,25,27)/t23-/m0/s1	KLANHRVIDUNZCQ-QHCPKHFHSA-N	242308	US9416129, 86	Beta-secretase 2		 3296						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242308	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242308&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222182	341094559							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422557	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(nc1)-n1cccn1	InChI=1S/C21H19FN6O2S2/c1-21(12-32(29,30)27(2)20(23)26-21)19-17(22)15-6-3-5-14(18(15)31-19)13-7-8-16(24-11-13)28-10-4-9-25-28/h3-11H,12H2,1-2H3,(H2,23,26)/t21-/m0/s1	PBCAUPSSKDKQBE-NRFANRHFSA-N	242309	US9416129, 87	Beta-secretase 2		 31						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242309&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222263	341094560							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422558	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-c1ncc(C)cn1	InChI=1S/C24H22FN5O2S2/c1-14-11-27-22(28-12-14)16-9-7-15(8-10-16)17-5-4-6-18-19(25)21(33-20(17)18)24(2)13-34(31,32)30(3)23(26)29-24/h4-12H,13H2,1-3H3,(H2,26,29)/t24-/m0/s1	XCFPWNHBKYXEDS-DEOSSOPVSA-N	242310	US9416129, 88	Beta-secretase 2		 3841						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242310	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242310&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222179	341094561							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422559	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-n1cccn1	InChI=1S/C22H20FN5O2S2/c1-22(13-32(29,30)27(2)21(24)26-22)20-18(23)17-6-3-5-16(19(17)31-20)14-7-9-15(10-8-14)28-12-4-11-25-28/h3-12H,13H2,1-2H3,(H2,24,26)/t22-/m0/s1	XHNUHGQIVJDKED-QFIPXVFZSA-N	242311	US9416129, 89	Beta-secretase 2		 68						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242311	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242311&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222264	341094562							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422560	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-c1ncco1	InChI=1S/C22H19FN4O3S2/c1-22(12-32(28,29)27(2)21(24)26-22)19-17(23)16-5-3-4-15(18(16)31-19)13-6-8-14(9-7-13)20-25-10-11-30-20/h3-11H,12H2,1-2H3,(H2,24,26)/t22-/m0/s1	LJNWYEBRTQYBML-QFIPXVFZSA-N	242312	US9416129, 90	Beta-secretase 2		 214						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242312	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242312&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222183	341094563							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422561	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-c1nccs1	InChI=1S/C22H19FN4O2S3/c1-22(12-32(28,29)27(2)21(24)26-22)19-17(23)16-5-3-4-15(18(16)31-19)13-6-8-14(9-7-13)20-25-10-11-30-20/h3-11H,12H2,1-2H3,(H2,24,26)/t22-/m0/s1	UTHIJPTYYLOQFP-QFIPXVFZSA-N	242313	US9416129, 91	Beta-secretase 2		 1353						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242313	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242313&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222262	341094564							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422562	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(cc1)-n1nccn1	InChI=1S/C21H19FN6O2S2/c1-21(12-32(29,30)27(2)20(23)26-21)19-17(22)16-5-3-4-15(18(16)31-19)13-6-8-14(9-7-13)28-24-10-11-25-28/h3-11H,12H2,1-2H3,(H2,23,26)/t21-/m0/s1	IFRGEJIEYBKOKV-NRFANRHFSA-N	242314	US9416129, 92	Beta-secretase 2		 1657						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242314	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242314&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222265	341094565							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422563	CN1CCN(CC1)c1ccc(cn1)-c1cccc2c(F)c(sc12)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C23H27FN6O2S2/c1-23(14-34(31,32)29(3)22(25)27-23)21-19(24)17-6-4-5-16(20(17)33-21)15-7-8-18(26-13-15)30-11-9-28(2)10-12-30/h4-8,13H,9-12,14H2,1-3H3,(H2,25,27)/t23-/m0/s1	RIEWQTPJALLPIR-QHCPKHFHSA-N	242315	US9416129, 93	Beta-secretase 2		 2659						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242315	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242315&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222092	341094566							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422564	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(nc1)N1CCOCC1	InChI=1S/C22H24FN5O3S2/c1-22(13-33(29,30)27(2)21(24)26-22)20-18(23)16-5-3-4-15(19(16)32-20)14-6-7-17(25-12-14)28-8-10-31-11-9-28/h3-7,12H,8-11,13H2,1-2H3,(H2,24,26)/t22-/m0/s1	NEBIRQVWSPJXKC-QFIPXVFZSA-N	242316	US9416129, 94	Beta-secretase 2		 9524						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242316	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242316&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222093	341094567							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422565	CN1CCN(CC1)c1ccc(cc1)-c1cccc2c(F)c(sc12)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C24H28FN5O2S2/c1-24(15-34(31,32)29(3)23(26)27-24)22-20(25)19-6-4-5-18(21(19)33-22)16-7-9-17(10-8-16)30-13-11-28(2)12-14-30/h4-10H,11-15H2,1-3H3,(H2,26,27)/t24-/m0/s1	VZHCZUYETOKUAL-DEOSSOPVSA-N	242317	US9416129, 95	Beta-secretase 2		 2030						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242317	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242317&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222094	341094568							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422566	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(cccc2c1F)-c1ccc(nc1)C1CC1	InChI=1S/C21H21FN4O2S2/c1-21(11-30(27,28)26(2)20(23)25-21)19-17(22)15-5-3-4-14(18(15)29-19)13-8-9-16(24-10-13)12-6-7-12/h3-5,8-10,12H,6-7,11H2,1-2H3,(H2,23,25)/t21-/m0/s1	FEIOSFPGQLXUDI-NRFANRHFSA-N	242318	US9416129, 96	Beta-secretase 2		 9524						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242318	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242318&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222095	341094569							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422567	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1cnc(nc1)-n1cccn1	InChI=1S/C19H17ClN8O2S2/c1-19(10-32(29,30)27(2)17(21)26-19)16-13(20)12-4-6-22-14(15(12)31-16)11-8-23-18(24-9-11)28-7-3-5-25-28/h3-9H,10H2,1-2H3,(H2,21,26)/t19-/m0/s1	KVYURCBXNYPYHU-IBGZPJMESA-N	242319	US9416129, 97	Beta-secretase 2		 64						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242319	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242319&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424769	341094570							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422568	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-c1cc(n[nH]1)C(F)(F)F			242320	US9416129, 98	Beta-secretase 2		 6.7						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242320&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129625870	341094571							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422569	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-n1nccn1	InChI=1S/C20H18ClN7O2S2/c1-20(11-32(29,30)27(2)19(22)26-20)18-15(21)14-7-8-23-16(17(14)31-18)12-3-5-13(6-4-12)28-24-9-10-25-28/h3-10H,11H2,1-2H3,(H2,22,26)/t20-/m0/s1	KTWWSGHHEGKDGG-FQEVSTJZSA-N	242321	US9416129, 99	Beta-secretase 2		 855						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242321	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242321&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424773	341094572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422570	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-c1ncco1	InChI=1S/C21H18ClN5O3S2/c1-21(11-32(28,29)27(2)20(23)26-21)18-15(22)14-7-8-24-16(17(14)31-18)12-3-5-13(6-4-12)19-25-9-10-30-19/h3-10H,11H2,1-2H3,(H2,23,26)/t21-/m0/s1	XXBWDOSFNJOFLD-NRFANRHFSA-N	242322	US9416129, 100	Beta-secretase 2		 224						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242322&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424771	341094573							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422571	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)C1CC(=O)N1	InChI=1S/C21H20ClN5O3S2/c1-21(10-32(29,30)27(2)20(23)26-21)19-16(22)13-7-8-24-17(18(13)31-19)12-5-3-11(4-6-12)14-9-15(28)25-14/h3-8,14H,9-10H2,1-2H3,(H2,23,26)(H,25,28)/t14?,21-/m0/s1	PYAMHMXGYQCNNE-YNNZGITBSA-N	242323	US9416129, 101	Beta-secretase 2		 116						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242323	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242323&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424772	341094574							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422572	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-n1cccn1	InChI=1S/C21H19ClN6O2S2/c1-21(12-32(29,30)27(2)20(23)26-21)19-16(22)15-8-10-24-17(18(15)31-19)13-4-6-14(7-5-13)28-11-3-9-25-28/h3-11H,12H2,1-2H3,(H2,23,26)/t21-/m0/s1	JANCBTANJXRDER-NRFANRHFSA-N	242324	US9416129, 102	Beta-secretase 2		 959						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242324&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222346	341094575							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422573	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-c1ccn[nH]1			242325	US9416129, 103	Beta-secretase 2		 30						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242325	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242325&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424775	341094576							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422574	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-n1ccnn1	InChI=1S/C20H18ClN7O2S2/c1-20(11-32(29,30)27(2)19(22)25-20)18-15(21)14-7-8-23-16(17(14)31-18)12-3-5-13(6-4-12)28-10-9-24-26-28/h3-10H,11H2,1-2H3,(H2,22,25)/t20-/m0/s1	BIUKWWMLYYSLKI-FQEVSTJZSA-N	242326	US9416129, 104	Beta-secretase 2		 36						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242326&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424777	341094577							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422575	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-c1nccn1C	InChI=1S/C22H21ClN6O2S2/c1-22(12-33(30,31)29(3)21(24)27-22)19-16(23)15-8-9-25-17(18(15)32-19)13-4-6-14(7-5-13)20-26-10-11-28(20)2/h4-11H,12H2,1-3H3,(H2,24,27)/t22-/m0/s1	NYWFTZQXPZNPJM-QFIPXVFZSA-N	242327	US9416129, 105	Beta-secretase 2		 86						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242327&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424776	341094578							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422576	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1)-c1nccs1	InChI=1S/C21H18ClN5O2S3/c1-21(11-32(28,29)27(2)20(23)26-21)18-15(22)14-7-8-24-16(17(14)31-18)12-3-5-13(6-4-12)19-25-9-10-30-19/h3-10H,11H2,1-2H3,(H2,23,26)/t21-/m0/s1	XVXOYHWXCCEZTG-NRFANRHFSA-N	242328	US9416129, 106	Beta-secretase 2		 1639						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242328&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424774	341094579							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422577	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1ccoc1	InChI=1S/C22H18ClFN4O3S2/c1-22(11-33(29,30)28(2)21(25)27-22)20-17(23)15-5-7-26-18(19(15)32-20)14-4-3-12(9-16(14)24)13-6-8-31-10-13/h3-10H,11H2,1-2H3,(H2,25,27)/t22-/m0/s1	IPTVVDCITNVKMD-QFIPXVFZSA-N	242329	US9416129, 107	Beta-secretase 2		 270						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242329&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74222347	341094580							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422578	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1cnco1	InChI=1S/C21H17ClFN5O3S2/c1-21(9-33(29,30)28(2)20(24)27-21)19-16(22)13-5-6-26-17(18(13)32-19)12-4-3-11(7-14(12)23)15-8-25-10-31-15/h3-8,10H,9H2,1-2H3,(H2,24,27)/t21-/m0/s1	PQCJKIZLGHAAMH-NRFANRHFSA-N	242330	US9416129, 108	Beta-secretase 2		 19						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242330	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242330&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424780	341094581							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422579	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1ccoc1C	InChI=1S/C23H20ClFN4O3S2/c1-12-14(7-9-32-12)13-4-5-15(17(25)10-13)19-20-16(6-8-27-19)18(24)21(33-20)23(2)11-34(30,31)29(3)22(26)28-23/h4-10H,11H2,1-3H3,(H2,26,28)/t23-/m0/s1	FLBURUDRKSFKLP-QHCPKHFHSA-N	242331	US9416129, 109	Beta-secretase 2		 87						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242331	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242331&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424796	341094582							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422580	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1cocc1C	InChI=1S/C23H20ClFN4O3S2/c1-12-9-32-10-16(12)13-4-5-14(17(25)8-13)19-20-15(6-7-27-19)18(24)21(33-20)23(2)11-34(30,31)29(3)22(26)28-23/h4-10H,11H2,1-3H3,(H2,26,28)/t23-/m0/s1	CVMCZZLOPFZYSJ-QHCPKHFHSA-N	242332	US9416129, 110	Beta-secretase 2		 444						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242332	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242332&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424781	341094583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422581	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1ccnn1C	InChI=1S/C22H20ClFN6O2S2/c1-22(11-34(31,32)30(3)21(25)28-22)20-17(23)14-6-8-26-18(19(14)33-20)13-5-4-12(10-15(13)24)16-7-9-27-29(16)2/h4-10H,11H2,1-3H3,(H2,25,28)/t22-/m0/s1	DHYHNZGNWLSWMO-QFIPXVFZSA-N	242333	US9416129, 111	Beta-secretase 2		 27						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242333&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424782	341094584							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422582	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1cnn(C)c1	InChI=1S/C22H20ClFN6O2S2/c1-22(11-34(31,32)30(3)21(25)28-22)20-17(23)15-6-7-26-18(19(15)33-20)14-5-4-12(8-16(14)24)13-9-27-29(2)10-13/h4-10H,11H2,1-3H3,(H2,25,28)/t22-/m0/s1	UMAJNBHBWFJCOR-QFIPXVFZSA-N	242334	US9416129, 112	Beta-secretase 2		 218						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242334	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242334&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424783	341094585							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422583	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1cncs1	InChI=1S/C21H17ClFN5O2S3/c1-21(9-33(29,30)28(2)20(24)27-21)19-16(22)13-5-6-26-17(18(13)32-19)12-4-3-11(7-14(12)23)15-8-25-10-31-15/h3-8,10H,9H2,1-2H3,(H2,24,27)/t21-/m0/s1	DMWQKGXRJJNSHP-NRFANRHFSA-N	242335	US9416129, 113	Beta-secretase 2		 252						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242335	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242335&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424785	341094586							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422584	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-c1cn[nH]c1			242336	US9416129, 114	Beta-secretase 2		 134						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242336&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424784	341094587							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422585	COc1cnn(c1)-c1ccc(c(F)c1)-c1nccc2c(Cl)c(sc12)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C22H20ClFN6O3S2/c1-22(11-35(31,32)29(2)21(25)28-22)20-17(23)15-6-7-26-18(19(15)34-20)14-5-4-12(8-16(14)24)30-10-13(33-3)9-27-30/h4-10H,11H2,1-3H3,(H2,25,28)/t22-/m0/s1	UZQRFUYYBXHESD-QFIPXVFZSA-N	242337	US9416129, 115	Beta-secretase 2		 267						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242337	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242337&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424786	341094588							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422586	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-n1cccn1	InChI=1S/C21H18ClFN6O2S2/c1-21(11-33(30,31)28(2)20(24)27-21)19-16(22)14-6-8-25-17(18(14)32-19)13-5-4-12(10-15(13)23)29-9-3-7-26-29/h3-10H,11H2,1-2H3,(H2,24,27)/t21-/m0/s1	CNNFEFVBNLJBPP-NRFANRHFSA-N	242338	US9416129, 116	Beta-secretase 2		 110						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242338	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242338&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424788	341094589							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422587	CCCc1cnn(c1)-c1ccc(c(F)c1)-c1nccc2c(Cl)c(sc12)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C24H24ClFN6O2S2/c1-4-5-14-11-29-32(12-14)15-6-7-16(18(26)10-15)20-21-17(8-9-28-20)19(25)22(35-21)24(2)13-36(33,34)31(3)23(27)30-24/h6-12H,4-5,13H2,1-3H3,(H2,27,30)/t24-/m0/s1	AYIWMZNVPWVONU-DEOSSOPVSA-N	242339	US9416129, 117	Beta-secretase 2		 35						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242339&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424787	341094590							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422588	CCc1cnn(c1)-c1ccc(c(F)c1)-c1nccc2c(Cl)c(sc12)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C23H22ClFN6O2S2/c1-4-13-10-28-31(11-13)14-5-6-15(17(25)9-14)19-20-16(7-8-27-19)18(24)21(34-20)23(2)12-35(32,33)30(3)22(26)29-23/h5-11H,4,12H2,1-3H3,(H2,26,29)/t23-/m0/s1	XWTJUWGJBYJYDS-QHCPKHFHSA-N	242340	US9416129, 118	Beta-secretase 2		 702						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242340&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424789	341094591							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422589	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)-c1ccc(cc1F)-n1cc(C)cn1	InChI=1S/C22H20ClFN6O2S2/c1-12-9-27-30(10-12)13-4-5-14(16(24)8-13)18-19-15(6-7-26-18)17(23)20(33-19)22(2)11-34(31,32)29(3)21(25)28-22/h4-10H,11H2,1-3H3,(H2,25,28)/t22-/m0/s1	QXJAGGVQMNHXBA-QFIPXVFZSA-N	242341	US9416129, 119	Beta-secretase 2		 417						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242341	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242341&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424790	341094592							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422590	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)N1CCN(CC1)c1nonc1C	InChI=1S/C19H23ClN8O3S2/c1-11-16(25-31-24-11)27-6-8-28(9-7-27)17-14-12(4-5-22-17)13(20)15(32-14)19(2)10-33(29,30)26(3)18(21)23-19/h4-5H,6-10H2,1-3H3,(H2,21,23)/t19-/m0/s1	LPASGRSCSBQHPG-IBGZPJMESA-N	242342	US9416129, 120	Beta-secretase 2		 96						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242342&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424792	341094593							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422591	COc1ccnc(c1)N1CCN(CC1)c1nccc2c(Cl)c(sc12)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C22H26ClN7O3S2/c1-22(13-35(31,32)28(2)21(24)27-22)19-17(23)15-5-7-26-20(18(15)34-19)30-10-8-29(9-11-30)16-12-14(33-3)4-6-25-16/h4-7,12H,8-11,13H2,1-3H3,(H2,24,27)/t22-/m0/s1	JTSNCCGBWXNHAI-QFIPXVFZSA-N	242343	US9416129, 121	Beta-secretase 2		 1262						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242343	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242343&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424793	341094594							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
422592	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc2c(nccc2c1Cl)N1CCC(CC1)c1nc(C)ns1	InChI=1S/C20H24ClN7O2S3/c1-11-24-18(32-26-11)12-5-8-28(9-6-12)17-15-13(4-7-23-17)14(21)16(31-15)20(2)10-33(29,30)27(3)19(22)25-20/h4,7,12H,5-6,8-10H2,1-3H3,(H2,22,25)/t20-/m0/s1	VJERMIPRJPUJHG-FQEVSTJZSA-N	242344	US9416129, 122	Beta-secretase 2		 408						5	30.00 C	US Patent		10.7270/Q2HM57C6		aid1803299	US9416129	Gilbert, EJ; Cumming, JN; Stamford, AW; Yu, Y; Scott, JD; Iserloh, U; Wang, L; Caldwell, JP	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242344	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242344&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118424794	341094595							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431495	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H17ClFN5O2S2/c1-17(9-28(25,26)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(27)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,27)/t17-/m0/s1	ODGKLSGTGUYQBK-KRWDZBQOSA-N	247276	US9447085, 1	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247276	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247276&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			74766514	346541819							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431496	COc1ccc(nc1)C(=S)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C18H20FN5O3S2/c1-18(10-29(25,26)24(2)17(20)23-18)13-8-11(4-6-14(13)19)22-16(28)15-7-5-12(27-3)9-21-15/h4-9H,10H2,1-3H3,(H2,20,23)(H,22,28)/t18-/m0/s1	OCVNTFGSDBGEQX-SFHVURJKSA-N	247277	US9447085, 2	Beta-secretase 2		 8						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247277	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247277&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284125	346541820							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431497	COCC(=S)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C14H19FN4O3S2/c1-14(8-24(20,21)19(2)13(16)18-14)10-6-9(4-5-11(10)15)17-12(23)7-22-3/h4-6H,7-8H2,1-3H3,(H2,16,18)(H,17,23)/t14-/m0/s1	RKZXWUOYKZPZMS-AWEZNQCLSA-N	247278	US9447085, 3	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247278	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247278&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284126	346541821							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431498	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)C(F)F)ccc1F	InChI=1S/C13H15F3N4O2S2/c1-13(6-24(21,22)20(2)12(17)19-13)8-5-7(3-4-9(8)14)18-11(23)10(15)16/h3-5,10H,6H2,1-2H3,(H2,17,19)(H,18,23)/t13-/m0/s1	LGWFWNAMIOFNML-ZDUSSCGKSA-N	247279	US9447085, 4	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247279	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247279&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284127	346541822							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431499	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C18H17F4N5O2S2/c1-17(9-31(28,29)27(2)16(23)26-17)12-7-11(4-5-13(12)19)25-15(30)14-6-3-10(8-24-14)18(20,21)22/h3-8H,9H2,1-2H3,(H2,23,26)(H,25,30)/t17-/m0/s1	SNVDXMFUYVELBH-KRWDZBQOSA-N	247280	US9447085, 4a	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247280	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247280&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284128	346541823							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431500	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)c2ccc(F)cn2)ccc1F	InChI=1S/C17H17F2N5O2S2/c1-17(9-28(25,26)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(27)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,27)/t17-/m0/s1	FUVBHHZXMIZBJO-KRWDZBQOSA-N	247281	US9447085, 4b	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247281	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247281&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284129	346541824							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431501	COc1cnc(cn1)C(=S)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H19FN6O3S2/c1-17(9-29(25,26)24(2)16(19)23-17)11-6-10(4-5-12(11)18)22-15(28)13-7-21-14(27-3)8-20-13/h4-8H,9H2,1-3H3,(H2,19,23)(H,22,28)/t17-/m0/s1	WVIMFRMFHOKKED-KRWDZBQOSA-N	247282	US9447085, 4c	Beta-secretase 2		 4						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247282	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247282&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284384	346541825							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431502	CO\N=C(\Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1)c1ccc(OC)cn1	InChI=1S/C19H23FN6O4S/c1-19(11-31(27,28)26(2)18(21)24-19)14-9-12(5-7-15(14)20)23-17(25-30-4)16-8-6-13(29-3)10-22-16/h5-10H,11H2,1-4H3,(H2,21,24)(H,23,25)/t19-/m0/s1	VQGLZCUJHDZRDR-IBGZPJMESA-N	247283	US9447085, 5	Beta-secretase 2		 1450						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247283	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247283&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284385	346541826							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431503	CO\N=C(\Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1)c1ccc(Cl)cn1	InChI=1S/C18H20ClFN6O3S/c1-18(10-30(27,28)26(2)17(21)24-18)13-8-12(5-6-14(13)20)23-16(25-29-3)15-7-4-11(19)9-22-15/h4-9H,10H2,1-3H3,(H2,21,24)(H,23,25)/t18-/m0/s1	GTXHZEUPZXDNFD-SFHVURJKSA-N	247284	US9447085, 6	Beta-secretase 2		 58						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247284&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284386	346541827							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431504	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=N)c2ccc(Br)cn2)ccc1F	InChI=1S/C17H18BrFN6O2S/c1-17(9-28(26,27)25(2)16(21)24-17)12-7-11(4-5-13(12)19)23-15(20)14-6-3-10(18)8-22-14/h3-8H,9H2,1-2H3,(H2,20,23)(H2,21,24)/t17-/m0/s1	LSSMWMYJRZHNEP-KRWDZBQOSA-N	247285	US9447085, 7	Beta-secretase 2		 148						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247285&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284387	346541828							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431505	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C17H16ClF2N5O2S2/c1-17(8-29(26,27)25(2)16(21)24-17)11-5-10(6-12(19)14(11)20)23-15(28)13-4-3-9(18)7-22-13/h3-7H,8H2,1-2H3,(H2,21,24)(H,23,28)/t17-/m0/s1	LTFKPHZPADNCFM-KRWDZBQOSA-N	247292	US9447085, 8	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247292	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247292&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284388	346541835							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431506	COc1ccc(nc1)C(=S)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C18H19F2N5O3S2/c1-18(9-30(26,27)25(2)17(21)24-18)12-6-10(7-13(19)15(12)20)23-16(29)14-5-4-11(28-3)8-22-14/h4-8H,9H2,1-3H3,(H2,21,24)(H,23,29)/t18-/m0/s1	TZPXPQJRKFFPME-SFHVURJKSA-N	247286	US9447085, 9	Beta-secretase 2		 15						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247286&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284389	346541829							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431507	COCC(=S)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C14H18F2N4O3S2/c1-14(7-25(21,22)20(2)13(17)19-14)9-4-8(5-10(15)12(9)16)18-11(24)6-23-3/h4-5H,6-7H2,1-3H3,(H2,17,19)(H,18,24)/t14-/m0/s1	LPCVMMNYJSKSGL-AWEZNQCLSA-N	247287	US9447085, 10	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247287	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247287&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284651	346541830							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431508	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)C(F)F)cc(F)c1F	InChI=1S/C13H14F4N4O2S2/c1-13(5-25(22,23)21(2)12(18)20-13)7-3-6(4-8(14)9(7)15)19-11(24)10(16)17/h3-4,10H,5H2,1-2H3,(H2,18,20)(H,19,24)/t13-/m0/s1	WFOVGIKAMRQWRU-ZDUSSCGKSA-N	247288	US9447085, 11	Beta-secretase 2		 28						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247288	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247288&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284652	346541831							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431509	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)c2ccc(F)cn2)cc(F)c1F	InChI=1S/C17H16F3N5O2S2/c1-17(8-29(26,27)25(2)16(21)24-17)11-5-10(6-12(19)14(11)20)23-15(28)13-4-3-9(18)7-22-13/h3-7H,8H2,1-2H3,(H2,21,24)(H,23,28)/t17-/m0/s1	AZXUJPQSSFWKSY-KRWDZBQOSA-N	247289	US9447085, 12	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247289&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284653	346541832							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431510	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)c2ccc(cn2)C(F)(F)F)cc(F)c1F	InChI=1S/C18H16F5N5O2S2/c1-17(8-32(29,30)28(2)16(24)27-17)11-5-10(6-12(19)14(11)20)26-15(31)13-4-3-9(7-25-13)18(21,22)23/h3-7H,8H2,1-2H3,(H2,24,27)(H,26,31)/t17-/m0/s1	WYSAWMUZCGRKOK-KRWDZBQOSA-N	247290	US9447085, 13	Beta-secretase 2		 21						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247290&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284654	346541833							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
431511	COc1cnc(cn1)C(=S)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H18F2N6O3S2/c1-17(8-30(26,27)25(2)16(20)24-17)10-4-9(5-11(18)14(10)19)23-15(29)12-6-22-13(28-3)7-21-12/h4-7H,8H2,1-3H3,(H2,20,24)(H,23,29)/t17-/m0/s1	WVDWLAJFKBZSOK-KRWDZBQOSA-N	247291	US9447085, 14	Beta-secretase 2		 18						5	30.00 C	US Patent		10.7270/Q2348J9M		aid1803419	US9447085	Cumming, JN; Scott, JD; Biftu, T	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247291	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247291&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76284655	346541834							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434661	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H21FN6O3S/c1-20(12-32(30,31)21(19(24)27-20)10-28(2)11-21)15-7-14(4-5-16(15)22)26-18(29)17-6-3-13(8-23)9-25-17/h3-7,9H,10-12H2,1-2H3,(H2,24,27)(H,26,29)/t20-/m0/s1	YNEIJINVPWTIAW-FQEVSTJZSA-N	249087	US9453034, 1	Beta-secretase 2		 1.4						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249087	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249087&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471649	346543598							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434662	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H21F2N5O3S/c1-19(11-31(29,30)20(18(23)26-19)9-27(2)10-20)14-7-13(4-5-15(14)22)25-17(28)16-6-3-12(21)8-24-16/h3-8H,9-11H2,1-2H3,(H2,23,26)(H,25,28)/t19-/m0/s1	SZIHHSLDDKJFCU-IBGZPJMESA-N	249088	US9453034, 2	Beta-secretase 2		 1.2						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249088&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471650	346543599							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434663	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CN(C)C2)C(=N)N1	InChI=1S/C21H24FN5O4S/c1-20(12-32(29,30)21(19(23)26-20)10-27(2)11-21)15-8-13(4-6-16(15)22)25-18(28)17-7-5-14(31-3)9-24-17/h4-9H,10-12H2,1-3H3,(H2,23,26)(H,25,28)/t20-/m0/s1	NQKGKNFRARZHHW-FQEVSTJZSA-N	249089	US9453034, 3	Beta-secretase 2		 1.6						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249089&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471651	346543600							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434664	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CN(C)C2)C(=N)N1	InChI=1S/C20H23FN6O4S/c1-19(11-32(29,30)20(18(22)26-19)9-27(2)10-20)13-6-12(4-5-14(13)21)25-17(28)15-7-24-16(31-3)8-23-15/h4-8H,9-11H2,1-3H3,(H2,22,26)(H,25,28)/t19-/m0/s1	XNNVDBCJJBLSID-IBGZPJMESA-N	249090	US9453034, 4	Beta-secretase 2		 6.2						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249090&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471652	346543601							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434665	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H21ClFN5O3S/c1-19(11-31(29,30)20(18(23)26-19)9-27(2)10-20)14-7-13(4-5-15(14)22)25-17(28)16-6-3-12(21)8-24-16/h3-8H,9-11H2,1-2H3,(H2,23,26)(H,25,28)/t19-/m0/s1	JOSATGAYPZWFMY-IBGZPJMESA-N	249091	US9453034, 5	Beta-secretase 2		 0.4						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249091&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471653	346543602							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434666	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(OC(F)(F)F)cn2)ccc1F	InChI=1S/C21H21F4N5O4S/c1-19(11-35(32,33)20(18(26)29-19)9-30(2)10-20)14-7-12(3-5-15(14)22)28-17(31)16-6-4-13(8-27-16)34-21(23,24)25/h3-8H,9-11H2,1-2H3,(H2,26,29)(H,28,31)/t19-/m0/s1	HMAVKEZTRORLPM-IBGZPJMESA-N	249092	US9453034, 6	Beta-secretase 2		 10.3						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249092&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471774	346543603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434667	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C21H22F3N5O4S/c1-20(11-34(31,32)21(18(25)28-20)9-29(2)10-21)14-7-12(3-5-15(14)22)27-17(30)16-6-4-13(8-26-16)33-19(23)24/h3-8,19H,9-11H2,1-2H3,(H2,25,28)(H,27,30)/t20-/m0/s1	ZNVPCWFQKHJDHK-FQEVSTJZSA-N	249093	US9453034, 7	Beta-secretase 2		 4.3						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249093&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471775	346543604							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434668	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C21H23F2N5O4S/c1-20(11-33(30,31)21(19(24)27-20)9-28(2)10-21)15-7-13(3-5-16(15)23)26-18(29)17-6-4-14(8-25-17)32-12-22/h3-8H,9-12H2,1-2H3,(H2,24,27)(H,26,29)/t20-/m0/s1	ZQXHFKWRSMZURN-FQEVSTJZSA-N	249094	US9453034, 8	Beta-secretase 2		 1.5						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249094&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471776	346543605							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434669	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C3(CN(C)C3)C(=N)N2)c(C)c1	InChI=1S/C22H26FN5O4S/c1-13-7-15(32-4)9-25-18(13)19(29)26-14-5-6-17(23)16(8-14)21(2)12-33(30,31)22(20(24)27-21)10-28(3)11-22/h5-9H,10-12H2,1-4H3,(H2,24,27)(H,26,29)/t21-/m0/s1	QUTMFPZGOBVBDF-NRFANRHFSA-N	249095	US9453034, 9	Beta-secretase 2		 0.9						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249095&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471777	346543606							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434670	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C3(CN(C)C3)C(=N)N2)c(C)n1	InChI=1S/C21H25FN6O4S/c1-12-17(24-8-16(25-12)32-4)18(29)26-13-5-6-15(22)14(7-13)20(2)11-33(30,31)21(19(23)27-20)9-28(3)10-21/h5-8H,9-11H2,1-4H3,(H2,23,27)(H,26,29)/t20-/m0/s1	DHPOGPIGPJUIBY-FQEVSTJZSA-N	249096	US9453034, 10	Beta-secretase 2		 4.9						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249096&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471778	346543607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434671	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C22H23FN6O3S/c1-13-6-14(8-24)9-26-18(13)19(30)27-15-4-5-17(23)16(7-15)21(2)12-33(31,32)22(20(25)28-21)10-29(3)11-22/h4-7,9H,10-12H2,1-3H3,(H2,25,28)(H,27,30)/t21-/m0/s1	QCOHZBSZFIESBV-NRFANRHFSA-N	249097	US9453034, 11	Beta-secretase 2		 1.0						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249097&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471904	346543608							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434672	CC#CCOc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CN(C)C2)C(=N)N1	InChI=1S/C24H26FN5O4S/c1-4-5-10-34-17-7-9-20(27-12-17)21(31)28-16-6-8-19(25)18(11-16)23(2)15-35(32,33)24(22(26)29-23)13-30(3)14-24/h6-9,11-12H,10,13-15H2,1-3H3,(H2,26,29)(H,28,31)/t23-/m0/s1	QLVXMZONSZVPIM-QHCPKHFHSA-N	249098	US9453034, 12	Beta-secretase 2		 30						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249098&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471905	346543609							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434673	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ncc(cc2C2CC2)C#N)ccc1F	InChI=1S/C24H25FN6O3S/c1-23(13-35(33,34)24(22(27)30-23)11-31(2)12-24)18-8-16(5-6-19(18)25)29-21(32)20-17(15-3-4-15)7-14(9-26)10-28-20/h5-8,10,15H,3-4,11-13H2,1-2H3,(H2,27,30)(H,29,32)/t23-/m0/s1	ATGAHYDTJRUTBF-QHCPKHFHSA-N	249099	US9453034, 12a	Beta-secretase 2		 0.8						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249099&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471906	346543610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434674	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ncc(cc2C(F)F)C#N)ccc1F	InChI=1S/C22H21F3N6O3S/c1-21(11-35(33,34)22(20(27)30-21)9-31(2)10-22)15-6-13(3-4-16(15)23)29-19(32)17-14(18(24)25)5-12(7-26)8-28-17/h3-6,8,18H,9-11H2,1-2H3,(H2,27,30)(H,29,32)/t21-/m0/s1	DMVOTCVPZZUWSV-NRFANRHFSA-N	249100	US9453034, 12b	Beta-secretase 2		 0.5						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249100&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471907	346543611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434675	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C23H25FN6O3S/c1-22(14-34(32,33)23(21(26)29-22)7-9-30(2)10-8-23)17-11-16(4-5-18(17)24)28-20(31)19-6-3-15(12-25)13-27-19/h3-6,11,13H,7-10,14H2,1-2H3,(H2,26,29)(H,28,31)/t22-/m0/s1	NYROTPFSKHMAEQ-QFIPXVFZSA-N	249101	US9453034, 25	Beta-secretase 2		 8.4						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249101&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472310	346543612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434676	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H25F2N5O3S/c1-21(13-33(31,32)22(20(25)28-21)7-9-29(2)10-8-22)16-11-15(4-5-17(16)24)27-19(30)18-6-3-14(23)12-26-18/h3-6,11-12H,7-10,13H2,1-2H3,(H2,25,28)(H,27,30)/t21-/m0/s1	DCKPCTPPOFRSTR-NRFANRHFSA-N	249102	US9453034, 26	Beta-secretase 2		 6.4						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249102&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472311	346543613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434677	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCN(C)CC2)C(=N)N1	InChI=1S/C23H28FN5O4S/c1-22(14-34(31,32)23(21(25)28-22)8-10-29(2)11-9-23)17-12-15(4-6-18(17)24)27-20(30)19-7-5-16(33-3)13-26-19/h4-7,12-13H,8-11,14H2,1-3H3,(H2,25,28)(H,27,30)/t22-/m0/s1	BVAFEYOJRSVLCR-QFIPXVFZSA-N	249103	US9453034, 27	Beta-secretase 2		 24						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249103&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472312	346543614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434678	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCN(C)CC2)C(=N)N1	InChI=1S/C22H27FN6O4S/c1-21(13-34(31,32)22(20(24)28-21)6-8-29(2)9-7-22)15-10-14(4-5-16(15)23)27-19(30)17-11-26-18(33-3)12-25-17/h4-5,10-12H,6-9,13H2,1-3H3,(H2,24,28)(H,27,30)/t21-/m0/s1	GADWVJSWJVSXST-NRFANRHFSA-N	249104	US9453034, 28	Beta-secretase 2		 29						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249104	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249104&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472313	346543615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434679	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H25ClFN5O3S/c1-21(13-33(31,32)22(20(25)28-21)7-9-29(2)10-8-22)16-11-15(4-5-17(16)24)27-19(30)18-6-3-14(23)12-26-18/h3-6,11-12H,7-10,13H2,1-2H3,(H2,25,28)(H,27,30)/t21-/m0/s1	WPNWEQRBZCRLHY-NRFANRHFSA-N	249105	US9453034, 29	Beta-secretase 2		 3.0						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249105	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249105&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472443	346543616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434680	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(OC(F)(F)F)cn2)ccc1F	InChI=1S/C23H25F4N5O4S/c1-21(13-37(34,35)22(20(28)31-21)7-9-32(2)10-8-22)16-11-14(3-5-17(16)24)30-19(33)18-6-4-15(12-29-18)36-23(25,26)27/h3-6,11-12H,7-10,13H2,1-2H3,(H2,28,31)(H,30,33)/t21-/m0/s1	JEOKLBSBUZNZSZ-NRFANRHFSA-N	249106	US9453034, 30	Beta-secretase 2		 52						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249106&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472444	346543617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434681	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C23H26F3N5O4S/c1-22(13-36(33,34)23(20(27)30-22)7-9-31(2)10-8-23)16-11-14(3-5-17(16)24)29-19(32)18-6-4-15(12-28-18)35-21(25)26/h3-6,11-12,21H,7-10,13H2,1-2H3,(H2,27,30)(H,29,32)/t22-/m0/s1	ONTPROOJVGYJDM-QFIPXVFZSA-N	249107	US9453034, 31	Beta-secretase 2		 27						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249107&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472445	346543618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434682	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C23H27F2N5O4S/c1-22(13-35(32,33)23(21(26)29-22)7-9-30(2)10-8-23)17-11-15(3-5-18(17)25)28-20(31)19-6-4-16(12-27-19)34-14-24/h3-6,11-12H,7-10,13-14H2,1-2H3,(H2,26,29)(H,28,31)/t22-/m0/s1	UYPISSYRTXBMEG-QFIPXVFZSA-N	249108	US9453034, 32	Beta-secretase 2		 11						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249108&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472446	346543619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434683	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C3(CCN(C)CC3)C(=N)N2)c(C)c1	InChI=1S/C24H30FN5O4S/c1-15-11-17(34-4)13-27-20(15)21(31)28-16-5-6-19(25)18(12-16)23(2)14-35(32,33)24(22(26)29-23)7-9-30(3)10-8-24/h5-6,11-13H,7-10,14H2,1-4H3,(H2,26,29)(H,28,31)/t23-/m0/s1	BNOPLMXYTLJLQP-QHCPKHFHSA-N	249109	US9453034, 33	Beta-secretase 2		 23						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249109&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472447	346543620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434684	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C3(CCN(C)CO3)C(=N)N2)c(C)n1	InChI=1S/C22H27FN6O5S/c1-13-18(25-10-17(26-13)33-4)19(30)27-14-5-6-16(23)15(9-14)21(2)11-35(31,32)22(20(24)28-21)7-8-29(3)12-34-22/h5-6,9-10H,7-8,11-12H2,1-4H3,(H2,24,28)(H,27,30)/t21-,22?/m0/s1	PQWUIBXPQNWMNA-HMTLIYDFSA-N	249110	US9453034, 34	Beta-secretase 2		 23						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249110&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131635720	346543621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434685	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C24H27FN6O3S/c1-15-10-16(12-26)13-28-20(15)21(32)29-17-4-5-19(25)18(11-17)23(2)14-35(33,34)24(22(27)30-23)6-8-31(3)9-7-24/h4-5,10-11,13H,6-9,14H2,1-3H3,(H2,27,30)(H,29,32)/t23-/m0/s1	NRUBCOSEKGFZPQ-QHCPKHFHSA-N	249111	US9453034, 35	Beta-secretase 2		 24						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249111&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472571	346543622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434686	CC#CCOc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCN(C)CC2)C(=N)N1	InChI=1S/C26H30FN5O4S/c1-4-5-14-36-19-7-9-22(29-16-19)23(33)30-18-6-8-21(27)20(15-18)25(2)17-37(34,35)26(24(28)31-25)10-12-32(3)13-11-26/h6-9,15-16H,10-14,17H2,1-3H3,(H2,28,31)(H,30,33)/t25-/m0/s1	RZKUSOMDXZAIJY-VWLOTQADSA-N	249112	US9453034, 36	Beta-secretase 2		 30						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249112&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472572	346543623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434687	CN1CCC2(CC1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)C(F)F)ccc1F	InChI=1S/C18H23F3N4O3S/c1-17(12-9-11(3-4-13(12)19)23-15(26)14(20)21)10-29(27,28)18(16(22)24-17)5-7-25(2)8-6-18/h3-4,9,14H,5-8,10H2,1-2H3,(H2,22,24)(H,23,26)/t17-/m0/s1	DCYYANGPQBXCIX-KRWDZBQOSA-N	249113	US9453034, 36a	Beta-secretase 2		 210						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249113&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472573	346543624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434688	COCC(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCN(C)CC2)C(=N)N1	InChI=1S/C19H27FN4O4S/c1-18(14-10-13(4-5-15(14)20)22-16(25)11-28-3)12-29(26,27)19(17(21)23-18)6-8-24(2)9-7-19/h4-5,10H,6-9,11-12H2,1-3H3,(H2,21,23)(H,22,25)/t18-/m0/s1	IDFIYCKMSQTBPM-SFHVURJKSA-N	249114	US9453034, 36b	Beta-secretase 2		 56						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249114&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472574	346543625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434689	C[C@]1(CS(=O)(=O)C2(CNC2)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H19FN6O3S/c1-19(11-31(29,30)20(9-24-10-20)18(23)27-19)14-6-13(3-4-15(14)21)26-17(28)16-5-2-12(7-22)8-25-16/h2-6,8,24H,9-11H2,1H3,(H2,23,27)(H,26,28)/t19-/m0/s1	BHSQEGIREXMCMC-IBGZPJMESA-N	249115	US9453034, 36c	Beta-secretase 2		 2.6						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249115&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472575	346543626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434690	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CNC2)C(=N)N1	InChI=1S/C20H22FN5O4S/c1-19(11-31(28,29)20(9-23-10-20)18(22)26-19)14-7-12(3-5-15(14)21)25-17(27)16-6-4-13(30-2)8-24-16/h3-8,23H,9-11H2,1-2H3,(H2,22,26)(H,25,27)/t19-/m0/s1	QLTDBXXFYMAJCL-IBGZPJMESA-N	249116	US9453034, 36d	Beta-secretase 2		 16						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249116	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249116&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472694	346543627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434691	Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CNC2)C(=N)N1)C#N	InChI=1S/C21H21FN6O3S/c1-12-5-13(7-23)8-26-17(12)18(29)27-14-3-4-16(22)15(6-14)20(2)11-32(30,31)21(9-25-10-21)19(24)28-20/h3-6,8,25H,9-11H2,1-2H3,(H2,24,28)(H,27,29)/t20-/m0/s1	ATKAIMXQGZRDFH-FQEVSTJZSA-N	249117	US9453034, 36e	Beta-secretase 2		 1.8						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249117&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472695	346543628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434692	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CN(C2)C(C)=O)C(=N)N1	InChI=1S/C22H24FN5O5S/c1-13(29)28-10-22(11-28)20(24)27-21(2,12-34(22,31)32)16-8-14(4-6-17(16)23)26-19(30)18-7-5-15(33-3)9-25-18/h4-9H,10-12H2,1-3H3,(H2,24,27)(H,26,30)/t21-/m0/s1	NYVLZJCWVNZILF-NRFANRHFSA-N	249118	US9453034, 37	Beta-secretase 2		 1.1						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249118&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472696	346543629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434693	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CN(C2)S(C)(=O)=O)C(=N)N1	InChI=1S/C21H24FN5O6S2/c1-20(12-35(31,32)21(19(23)26-20)10-27(11-21)34(3,29)30)15-8-13(4-6-16(15)22)25-18(28)17-7-5-14(33-2)9-24-17/h4-9H,10-12H2,1-3H3,(H2,23,26)(H,25,28)/t20-/m0/s1	ZZLWMUZDZQSGEM-FQEVSTJZSA-N	249119	US9453034, 38	Beta-secretase 2		 2.3						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249119&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472697	346543630							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434694	CNC(=O)N1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(OC)cn2)ccc1F	InChI=1S/C22H25FN6O5S/c1-21(12-35(32,33)22(19(24)28-21)10-29(11-22)20(31)25-2)15-8-13(4-6-16(15)23)27-18(30)17-7-5-14(34-3)9-26-17/h4-9H,10-12H2,1-3H3,(H2,24,28)(H,25,31)(H,27,30)/t21-/m0/s1	PXSZYCDQHYLPTG-NRFANRHFSA-N	249120	US9453034, 39	Beta-secretase 2		 1.7						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249120&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472698	346543631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434695	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CN(Cc3ccccc3)C2)C(=N)N1	InChI=1S/C27H28FN5O4S/c1-26(21-12-19(8-10-22(21)28)31-24(34)23-11-9-20(37-2)13-30-23)17-38(35,36)27(25(29)32-26)15-33(16-27)14-18-6-4-3-5-7-18/h3-13H,14-17H2,1-2H3,(H2,29,32)(H,31,34)/t26-/m0/s1	BSABFXDZWHHBFF-SANMLTNESA-N	249121	US9453034, 40	Beta-secretase 2		 0.6						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249121&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85472816	346543632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
434696	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CN(C2)c2ccc(cc2)[N+]([O-])=O)C(=N)N1	InChI=1S/C26H25FN6O6S/c1-25(20-11-16(3-9-21(20)27)30-23(34)22-10-8-19(39-2)12-29-22)15-40(37,38)26(24(28)31-25)13-32(14-26)17-4-6-18(7-5-17)33(35)36/h3-12H,13-15H2,1-2H3,(H2,28,31)(H,30,34)/t25-/m0/s1	RMHMIIGNGBLSOY-VWLOTQADSA-N	249123	US9453034, 42	Beta-secretase 2		 0.32						5	30.00 C	US Patent		10.7270/Q27P8XBC		aid1803451	US9453034	Gilbert, EJ; Cumming, JN; Scott, JD; Wu, W; Burnett, DA; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249123&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91869946	346543633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451585	Cc1nnc(o1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C17H20FN5O4S/c1-9-22-23-14(27-9)13(24)20-10-5-6-12(18)11(7-10)17(4)8-28(25,26)16(2,3)15(19)21-17/h5-7H,8H2,1-4H3,(H2,19,21)(H,20,24)/t17-/m0/s1	NCCXDVHAQXDJBE-KRWDZBQOSA-N	258908	US9499502, 9i	Beta-secretase 2		 49						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258908&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094863	350083610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451586	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccn(n2)C(F)F)ccc1F	InChI=1S/C18H20F3N5O3S/c1-17(2)15(22)24-18(3,9-30(17,28)29)11-8-10(4-5-12(11)19)23-14(27)13-6-7-26(25-13)16(20)21/h4-8,16H,9H2,1-3H3,(H2,22,24)(H,23,27)/t18-/m0/s1	FXYJNHPENOFRMR-SFHVURJKSA-N	258909	US9499502, 9j	Beta-secretase 2		 16						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258909&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562763	350083611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451587	COc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H21F2N5O4S/c1-18(2)17(22)26-19(3,9-31(18,28)29)11-5-10(6-12(20)15(11)21)25-16(27)13-7-24-14(30-4)8-23-13/h5-8H,9H2,1-4H3,(H2,22,26)(H,25,27)/t19-/m0/s1	PCIZLWFYEMMQSK-IBGZPJMESA-N	258915	US9499502, 9n	Beta-secretase 2		 12						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258915&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562367	350083617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451588	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)cc(Cl)c1F	InChI=1S/C20H19ClF4N4O3S/c1-18(2)17(26)29-19(3,9-33(18,31)32)12-6-11(7-13(21)15(12)22)28-16(30)14-5-4-10(8-27-14)20(23,24)25/h4-8H,9H2,1-3H3,(H2,26,29)(H,28,30)/t19-/m0/s1	ALBXLBXZAXXFLJ-IBGZPJMESA-N	258921	US9499502, 9v	Beta-secretase 2		 13						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258921&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095031	350083623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451589	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1F)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H22F2N4O4S/c1-19(2)18(23)26-20(3,10-31(19,28)29)15-12(21)6-8-13(16(15)22)25-17(27)14-7-5-11(30-4)9-24-14/h5-9H,10H2,1-4H3,(H2,23,26)(H,25,27)/t20-/m0/s1	VPFQLLWQBBTNAJ-FQEVSTJZSA-N	258924	US9499502, 9y	Beta-secretase 2		 11						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258924&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095217	350083626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451590	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1F)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H21F2N5O4S/c1-18(2)17(22)26-19(3,9-31(18,28)29)14-10(20)5-6-11(15(14)21)25-16(27)12-7-24-13(30-4)8-23-12/h5-8H,9H2,1-4H3,(H2,22,26)(H,25,27)/t19-/m0/s1	WJRJCVKZWPGNOY-IBGZPJMESA-N	258925	US9499502, 9z	Beta-secretase 2		 59						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258925&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562768	350083627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451591	COc1ccc(nc1)C(=O)Nc1cc(F)c(F)c(c1F)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H21F3N4O4S/c1-19(2)18(24)27-20(3,9-32(19,29)30)14-15(22)11(21)7-13(16(14)23)26-17(28)12-6-5-10(31-4)8-25-12/h5-8H,9H2,1-4H3,(H2,24,27)(H,26,28)/t20-/m0/s1	XXOOZXXXKWDLIY-FQEVSTJZSA-N	258928	US9499502, 9ac	Beta-secretase 2		 13						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258928&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095218	350083630							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451592	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1c(F)c(F)cc(NC(=O)c2ccc(cn2)C(F)(F)F)c1F	InChI=1S/C20H18F6N4O3S/c1-18(2)17(27)30-19(3,8-34(18,32)33)13-14(22)10(21)6-12(15(13)23)29-16(31)11-5-4-9(7-28-11)20(24,25)26/h4-7H,8H2,1-3H3,(H2,27,30)(H,29,31)/t19-/m0/s1	JADYCCFHKXKMSB-IBGZPJMESA-N	258929	US9499502, 9ad	Beta-secretase 2		 41						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258929&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562860	350083631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451593	COc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1F)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H20F3N5O4S/c1-18(2)17(23)27-19(3,8-32(18,29)30)13-14(21)9(20)5-10(15(13)22)26-16(28)11-6-25-12(31-4)7-24-11/h5-7H,8H2,1-4H3,(H2,23,27)(H,26,28)/t19-/m0/s1	HVCPNUIXHPQNFR-IBGZPJMESA-N	258930	US9499502, 9ae	Beta-secretase 2		 69						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258930&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094870	350083632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451594	CC(F)(F)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H20F3N3O3S/c1-14(2)12(20)22-15(3,8-26(14,24)25)10-7-9(5-6-11(10)17)21-13(23)16(4,18)19/h5-7H,8H2,1-4H3,(H2,20,22)(H,21,23)/t15-/m0/s1	IYRBXXIGHWZJGZ-HNNXBMFYSA-N	258934	US9499502, 9ai	Beta-secretase 2		 18						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258934&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562863	350083636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451595	Cc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H22FN5O3S/c1-11-8-23-15(9-22-11)16(26)24-12-5-6-14(20)13(7-12)19(4)10-29(27,28)18(2,3)17(21)25-19/h5-9H,10H2,1-4H3,(H2,21,25)(H,24,26)/t19-/m0/s1	ZPCAFYZFQQTHRZ-IBGZPJMESA-N	258936	US9499502, 9ak	Beta-secretase 2		 13						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258936&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86715813	350083638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451596	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)[C@H]2CCCO2)ccc1F	InChI=1S/C18H24FN3O4S/c1-17(2)16(20)22-18(3,10-27(17,24)25)12-9-11(6-7-13(12)19)21-15(23)14-5-4-8-26-14/h6-7,9,14H,4-5,8,10H2,1-3H3,(H2,20,22)(H,21,23)/t14-,18+/m1/s1	CDSWIMKNSYLPBK-KDOFPFPSSA-N	258937	US9499502, 9al	Beta-secretase 2		 44						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258937&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562864	350083639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451597	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2cocn2)ccc1F	InChI=1S/C17H19FN4O4S/c1-16(2)15(19)22-17(3,8-27(16,24)25)11-6-10(4-5-12(11)18)21-14(23)13-7-26-9-20-13/h4-7,9H,8H2,1-3H3,(H2,19,22)(H,21,23)/t17-/m0/s1	CCDBGYQULIRJPM-KRWDZBQOSA-N	258941	US9499502, 9ap	Beta-secretase 2		 4						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258941&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094950	350083643							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451598	COCC(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H22FN3O4S/c1-15(2)14(18)20-16(3,9-25(15,22)23)11-7-10(5-6-12(11)17)19-13(21)8-24-4/h5-7H,8-9H2,1-4H3,(H2,18,20)(H,19,21)/t16-/m0/s1	KTRWPFQZWIRZRO-INIZCTEOSA-N	258945	US9499502, 9at	Beta-secretase 2		 14						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258945&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562957	350083647							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451599	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)C2CCC2(F)F)ccc1F	InChI=1S/C18H22F3N3O3S/c1-16(2)15(22)24-17(3,9-28(16,26)27)12-8-10(4-5-13(12)19)23-14(25)11-6-7-18(11,20)21/h4-5,8,11H,6-7,9H2,1-3H3,(H2,22,24)(H,23,25)/t11?,17-/m0/s1	DEQBGKOLUVGSOL-KLLZUTDZSA-N	258948	US9499502, 9aw	Beta-secretase 2		 47						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258948&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562959	350083650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451600	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccno2)ccc1F	InChI=1S/C17H19FN4O4S/c1-16(2)15(19)22-17(3,9-27(16,24)25)11-8-10(4-5-12(11)18)21-14(23)13-6-7-20-26-13/h4-8H,9H2,1-3H3,(H2,19,22)(H,21,23)/t17-/m0/s1	OCBCKNNSQWMJMI-KRWDZBQOSA-N	258949	US9499502, 9ax	Beta-secretase 2		 22						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258949&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094873	350083651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451601	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ncc(F)cc2F)cc(F)c1F	InChI=1S/C19H18F4N4O3S/c1-18(2)17(24)27-19(3,8-31(18,29)30)11-5-10(6-12(21)14(11)23)26-16(28)15-13(22)4-9(20)7-25-15/h4-7H,8H2,1-3H3,(H2,24,27)(H,26,28)/t19-/m0/s1	TYKNJIJSJJKNDB-IBGZPJMESA-N	258951	US9499502, 9ba	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258951&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562961	350083653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451602	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)C(F)F)cc(F)c1F	InChI=1S/C15H17F4N3O3S/c1-14(2)13(20)22-15(3,6-26(14,24)25)8-4-7(5-9(16)10(8)17)21-12(23)11(18)19/h4-5,11H,6H2,1-3H3,(H2,20,22)(H,21,23)/t15-/m0/s1	GROCMHLUXPORAE-HNNXBMFYSA-N	258953	US9499502, 9bd	Beta-secretase 2		 40						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258953&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094947	350083655							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451603	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)cc(F)c1F	InChI=1S/C20H19F5N4O3S/c1-18(2)17(26)29-19(3,9-33(18,31)32)12-6-11(7-13(21)15(12)22)28-16(30)14-5-4-10(8-27-14)20(23,24)25/h4-8H,9H2,1-3H3,(H2,26,29)(H,28,30)/t19-/m0/s1	IKSBELYCEUFIHH-IBGZPJMESA-N	258955	US9499502, 9bf	Beta-secretase 2		 11						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258955&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562962	350083657							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451604	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)cc(F)c1F	InChI=1S/C20H19F2N5O3S/c1-19(2)18(24)27-20(3,10-31(19,29)30)13-6-12(7-14(21)16(13)22)26-17(28)15-5-4-11(8-23)9-25-15/h4-7,9H,10H2,1-3H3,(H2,24,27)(H,26,28)/t20-/m0/s1	OQHATYXLJNAXPH-FQEVSTJZSA-N	258956	US9499502, 9bg	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258956&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094955	350083658							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451605	Cc1ccc(nc1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H22F2N4O3S/c1-11-5-6-15(24-9-11)17(27)25-12-7-13(16(22)14(21)8-12)20(4)10-30(28,29)19(2,3)18(23)26-20/h5-9H,10H2,1-4H3,(H2,23,26)(H,25,27)/t20-/m0/s1	KVYQRJSWPRRNAF-FQEVSTJZSA-N	258957	US9499502, 9bh	Beta-secretase 2		 4						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258957&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563056	350083659							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451606	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cc2)cc(F)c1F	InChI=1S/C20H20ClF2N3O3S/c1-19(2)18(24)26-20(3,10-30(19,28)29)14-8-13(9-15(22)16(14)23)25-17(27)11-4-6-12(21)7-5-11/h4-9H,10H2,1-3H3,(H2,24,26)(H,25,27)/t20-/m0/s1	MBVSHWRVUHFRMM-FQEVSTJZSA-N	258958	US9499502, 9bi	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258958&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094956	350083660							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451607	COCC(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H21F2N3O4S/c1-15(2)14(19)21-16(3,8-26(15,23)24)10-5-9(6-11(17)13(10)18)20-12(22)7-25-4/h5-6H,7-8H2,1-4H3,(H2,19,21)(H,20,22)/t16-/m0/s1	MOQYEOMDROTSCP-INIZCTEOSA-N	258960	US9499502, 9bk	Beta-secretase 2		 12						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258960&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563057	350083662							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451608	CC(F)(F)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C16H19F4N3O3S/c1-14(2)12(21)23-15(3,7-27(14,25)26)9-5-8(6-10(17)11(9)18)22-13(24)16(4,19)20/h5-6H,7H2,1-4H3,(H2,21,23)(H,22,24)/t15-/m0/s1	SSHXWPDCUDIQNH-HNNXBMFYSA-N	258961	US9499502, 9bl	Beta-secretase 2		 40						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258961&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094951	350083663							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451609	Cc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H21F2N5O3S/c1-10-7-24-14(8-23-10)16(27)25-11-5-12(15(21)13(20)6-11)19(4)9-30(28,29)18(2,3)17(22)26-19/h5-8H,9H2,1-4H3,(H2,22,26)(H,25,27)/t19-/m0/s1	FNCDVWGVMRRSPW-IBGZPJMESA-N	258964	US9499502, 9bo	Beta-secretase 2		 22						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258964&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563060	350083666							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451610	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2cocn2)cc(F)c1F	InChI=1S/C17H18F2N4O4S/c1-16(2)15(20)23-17(3,7-28(16,25)26)10-4-9(5-11(18)13(10)19)22-14(24)12-6-27-8-21-12/h4-6,8H,7H2,1-3H3,(H2,20,23)(H,22,24)/t17-/m0/s1	SAMYFOBCOCFQNG-KRWDZBQOSA-N	258970	US9499502, 9bu	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258970&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095161	350083672							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451611	COc1cnc(cn1)C(=O)Nc1cc(c(F)cc1Br)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H21BrFN5O4S/c1-18(2)17(22)26-19(3,9-31(18,28)29)10-5-13(11(20)6-12(10)21)25-16(27)14-7-24-15(30-4)8-23-14/h5-8H,9H2,1-4H3,(H2,22,26)(H,25,27)/t19-/m0/s1	MCFYSKMIEFBNKF-IBGZPJMESA-N	258973	US9499502, 9by	Beta-secretase 2		 2900						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258973&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094958	350083675							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451612	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2cnc(O)cn2)ccc1F	InChI=1S/C18H20FN5O4S/c1-17(2)16(20)24-18(3,9-29(17,27)28)11-6-10(4-5-12(11)19)23-15(26)13-7-22-14(25)8-21-13/h4-8H,9H2,1-3H3,(H2,20,24)(H,22,25)(H,23,26)/t18-/m0/s1	HJJCDTGCXVTDHN-SFHVURJKSA-N	258974	US9499502, 9bz	Beta-secretase 2		 13						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258974&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094878	350083676							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451613	CCC1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H20F2N4O3S/c1-3-16-17(22)25-19(2,10-29(16,27)28)13-8-12(5-6-14(13)21)24-18(26)15-7-4-11(20)9-23-15/h4-9,16H,3,10H2,1-2H3,(H2,22,25)(H,24,26)/t16?,19-/m0/s1	HXHNWBAGUAZKKZ-CVMIBEPCSA-N	258975	US9499502, 9ca	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258975&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095035	350083677							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451614	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C19H19F4N5O3S/c1-17(2)16(24)28-18(3,9-32(17,30)31)14-11(20)5-7-13(26-14)27-15(29)12-6-4-10(8-25-12)19(21,22)23/h4-8H,9H2,1-3H3,(H2,24,28)(H,26,27,29)/t18-/m0/s1	AYAJTJLCHBONCD-SFHVURJKSA-N	258980	US9499502, 9cf	Beta-secretase 2		 40						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258980&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095361	350083682							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451615	COc1cnc(cn1)C(=O)Nc1ccc(F)c(n1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H21FN6O4S/c1-17(2)16(20)25-18(3,9-30(17,27)28)14-10(19)5-6-12(23-14)24-15(26)11-7-22-13(29-4)8-21-11/h5-8H,9H2,1-4H3,(H2,20,25)(H,23,24,26)/t18-/m0/s1	PYROVEFAHOYHPD-SFHVURJKSA-N	258981	US9499502, 9cg	Beta-secretase 2		 85						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258981&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73670144	350083683							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451616	COc1ccc(nn1)C(=O)Nc1ccc(F)c(n1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H21FN6O4S/c1-17(2)16(20)23-18(3,9-30(17,27)28)14-10(19)5-7-12(21-14)22-15(26)11-6-8-13(29-4)25-24-11/h5-8H,9H2,1-4H3,(H2,20,23)(H,21,22,26)/t18-/m0/s1	VTKOYJZYLKHAHN-SFHVURJKSA-N	258983	US9499502, 9ci	Beta-secretase 2		 44						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258983&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095364	350083685							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451617	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc(NC(=O)c2cnc(cn2)C(F)F)ccc1F	InChI=1S/C18H19F3N6O3S/c1-17(2)16(22)27-18(3,8-31(17,29)30)13-9(19)4-5-12(25-13)26-15(28)11-7-23-10(6-24-11)14(20)21/h4-7,14H,8H2,1-3H3,(H2,22,27)(H,25,26,28)/t18-/m0/s1	JFETUAJQOJCLCW-SFHVURJKSA-N	258984	US9499502, 9cj	Beta-secretase 2		 21						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=258984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=258984&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095272	350083686							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451618	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=N)c2ncc(F)cc2F)ccc1F	InChI=1S/C19H20F3N5O2S/c1-18(2)17(24)27-19(3,9-30(18,28)29)12-7-11(4-5-13(12)21)26-16(23)15-14(22)6-10(20)8-25-15/h4-8H,9H2,1-3H3,(H2,23,26)(H2,24,27)/t19-/m0/s1	XANOCHKJRHQOAR-IBGZPJMESA-N	259068	US9499502, 9ef	Beta-secretase 2		 218						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259068&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095041	350083769							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451619	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)-c1cccc(c1)C#N	InChI=1S/C20H20FN3O2S/c1-19(2)18(23)24-20(3,12-27(19,25)26)16-10-15(7-8-17(16)21)14-6-4-5-13(9-14)11-22/h4-10H,12H2,1-3H3,(H2,23,24)/t20-/m0/s1	SHQIKGYPUZBLBG-FQEVSTJZSA-N	259069	US9499502, 10	Beta-secretase 2		 176						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259069&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563498	350083770							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451620	COc1cccc2cc([nH]c12)-c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1			259070	US9499502, 11	Beta-secretase 2		 13						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259070&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137853	350083771							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451621	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(ccc1F)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C21H20F2N4O3S/c1-20(2)19(24)26-21(3,10-31(20,28)29)16-9-12(4-5-17(16)23)13-6-14(8-15(22)7-13)18-27-25-11-30-18/h4-9,11H,10H2,1-3H3,(H2,24,26)/t21-/m0/s1	DGBRZIWWMKKRCQ-NRFANRHFSA-N	259071	US9499502, 16a	Beta-secretase 2		 445						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259071&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563502	350083772							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451622	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)Nc1cccc(Cl)n1	InChI=1S/C17H18Cl2N4O3S2/c1-16(2)15(20)23-17(3,8-28(16,25)26)13-9(18)7-10(27-13)14(24)22-12-6-4-5-11(19)21-12/h4-7H,8H2,1-3H3,(H2,20,23)(H,21,22,24)/t17-/m0/s1	QPSKLVOJEVEGJX-KRWDZBQOSA-N	259076	US9499502, 20	Beta-secretase 2		 8						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259076&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66563596	350083777							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451623	CC1=NOC(CNC(=O)c2cc(Cl)c(s2)[C@]2(C)CS(=O)(=O)C(C)(C)C(=N)N2)C1	InChI=1S/C17H23ClN4O4S2/c1-9-5-10(26-22-9)7-20-14(23)12-6-11(18)13(27-12)17(4)8-28(24,25)16(2,3)15(19)21-17/h6,10H,5,7-8H2,1-4H3,(H2,19,21)(H,20,23)/t10?,17-/m0/s1	VMSRYVFUGKAOSD-LKDXBUKQSA-N	259084	US9499502, 22f	Beta-secretase 2		 1800						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259084&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094922	350083785							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451624	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1cccc(c1)-c1ccon1	InChI=1S/C22H23ClN4O4S2/c1-21(2)20(24)26-22(3,12-33(21,29)30)18-15(23)10-17(32-18)19(28)25-11-13-5-4-6-14(9-13)16-7-8-31-27-16/h4-10H,11-12H2,1-3H3,(H2,24,26)(H,25,28)/t22-/m0/s1	AIFGVTQYFBWVGF-QFIPXVFZSA-N	259085	US9499502, 22g	Beta-secretase 2		 51						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259085&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094894	350083786							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451625	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)C(=O)NCc1cc(Cl)ccn1	InChI=1S/C18H20Cl2N4O3S2/c1-17(2)16(21)24-18(3,9-29(17,26)27)14-12(20)7-13(28-14)15(25)23-8-11-6-10(19)4-5-22-11/h4-7H,8-9H2,1-3H3,(H2,21,24)(H,23,25)/t18-/m0/s1	YZFSXNILTRMTEJ-SFHVURJKSA-N	259099	US9499502, 22u	Beta-secretase 2		 77						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259099&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095287	350083800							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451626	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C17H17ClN4O2S2/c1-16(2)15(20)22-17(3,9-26(16,23)24)14-12(18)5-13(25-14)11-4-10(6-19)7-21-8-11/h4-5,7-8H,9H2,1-3H3,(H2,20,22)/t17-/m0/s1	UFENPTPCZBUEGF-KRWDZBQOSA-N	259102	US9499502, 23	Beta-secretase 2		 314						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259102&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095374	350083802							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451627	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C19H19ClN4O3S2/c1-18(2)17(21)23-19(3,9-29(18,25)26)15-13(20)8-14(28-15)11-5-4-6-12(7-11)16-24-22-10-27-16/h4-8,10H,9H2,1-3H3,(H2,21,23)/t19-/m0/s1	ZDJHWLIIQJNZPU-IBGZPJMESA-N	259108	US9499502, 27ae::US9499502, 27b	Beta-secretase 2		 21						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259108&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137862	350083808							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451628	C[C@]1(CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C19H17F4N3O2S2/c1-17(10-30(27,28)18(2,16(25)26-17)9-19(21,22)23)15-13(20)7-14(29-15)12-5-3-4-11(6-12)8-24/h3-7H,9-10H2,1-2H3,(H2,25,26)/t17-,18-/m0/s1	XQOLXJKJFXAENW-ROUUACIJSA-N	259167	US9499502, 27bj-a	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259167&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094909	350083865							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451629	C[C@]1(CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1)c1sc(cc1F)-c1cccc(c1)-c1nnco1	InChI=1S/C20H18F4N4O3S2/c1-18(9-33(29,30)19(2,17(25)27-18)8-20(22,23)24)15-13(21)7-14(32-15)11-4-3-5-12(6-11)16-28-26-10-31-16/h3-7,10H,8-9H2,1-2H3,(H2,25,27)/t18-,19-/m0/s1	LJVPBFAZHIFHIY-OALUTQOASA-N	259169	US9499502, 27bk-a	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259169&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137896	350083867							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451630	COc1cccc(c1)-c1cc(F)c(s1)[C@]1(C)CS(=O)(=O)[C@@](C)(CC(F)(F)F)C(=N)N1	InChI=1S/C19H20F4N2O3S2/c1-17(10-30(26,27)18(2,16(24)25-17)9-19(21,22)23)15-13(20)8-14(29-15)11-5-4-6-12(7-11)28-3/h4-8H,9-10H2,1-3H3,(H2,24,25)/t17-,18-/m0/s1	JECHMSBNYOTNJQ-ROUUACIJSA-N	259171	US9499502, 27bl-a	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259171&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095387	350083869							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451631	C[C@]1(CS(=O)(=O)C(C)(CC(F)(F)F)C(=N)N1)c1sc(cc1F)-c1ccc(F)c(c1)C#N	InChI=1S/C19H16F5N3O2S2/c1-17(9-31(28,29)18(2,16(26)27-17)8-19(22,23)24)15-13(21)6-14(30-15)10-3-4-12(20)11(5-10)7-25/h3-6H,8-9H2,1-2H3,(H2,26,27)/t17-,18?/m0/s1	NYMQCQXBRWDRNJ-ZENAZSQFSA-N	259173	US9499502, 27bm-a	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259173&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137898	350083871							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451632	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1cccc(F)c1)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C23H19F2N3O2S2/c1-22(20-18(25)11-19(31-20)15-6-3-5-14(9-15)12-26)13-32(29,30)23(2,21(27)28-22)16-7-4-8-17(24)10-16/h3-11H,13H2,1-2H3,(H2,27,28)/t22-,23-/m0/s1	PWYWDLXTZZYHQW-GOTSBHOMSA-N	259181	US9499502, 27br-a	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259181&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137905	350083879							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451633	C[C@]1(CS(=O)(=O)[C@](C)(C(=N)N1)c1ccccc1F)c1sc(cc1F)-c1cccc(c1)C#N	InChI=1S/C23H19F2N3O2S2/c1-22(20-18(25)11-19(31-20)15-7-5-6-14(10-15)12-26)13-32(29,30)23(2,21(27)28-22)16-8-3-4-9-17(16)24/h3-11H,13H2,1-2H3,(H2,27,28)/t22-,23-/m0/s1	WJAPMRNJIJYRHN-GOTSBHOMSA-N	259183	US9499502, 27bs-a	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259183&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90137907	350083881							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451634	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1nc(Nc2cccc(Cl)c2F)ccc1F	InChI=1S/C18H19ClF2N4O2S/c1-17(2)16(22)25-18(3,9-28(17,26)27)15-11(20)7-8-13(24-15)23-12-6-4-5-10(19)14(12)21/h4-8H,9H2,1-3H3,(H2,22,25)(H,23,24)/t18-/m0/s1	ZKWCJXOVBHYDOX-SFHVURJKSA-N	259203	US9499502, 30	Beta-secretase 2		 862						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259203&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562148	350083901							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451635	COc1ccccc1Nc1ccc(F)c(n1)[C@@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C19H23FN4O3S/c1-18(2)17(21)24-19(3,11-28(18,25)26)16-12(20)9-10-15(23-16)22-13-7-5-6-8-14(13)27-4/h5-10H,11H2,1-4H3,(H2,21,24)(H,22,23)/t19-/m1/s1	IKCNHOFMMPVTAG-LJQANCHMSA-N	259204	US9499502, 30a	Beta-secretase 2		 517						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259204&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953976	350083902							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451636	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(Nc2noc3cc(F)cnc23)ccc1F	InChI=1S/C19H19F2N5O3S/c1-18(2)17(22)25-19(3,9-30(18,27)28)12-7-11(4-5-13(12)21)24-16-15-14(29-26-16)6-10(20)8-23-15/h4-8H,9H2,1-3H3,(H2,22,25)(H,24,26)/t19-/m0/s1	NDBAFCPTBXSRHA-IBGZPJMESA-N	259205	US9499502, 30b	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259205&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095177	350083903							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451637	COc1ccc(cc1)C#Cc1ccc(F)c(n1)C1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C21H22FN3O3S/c1-20(2)19(23)25-21(3,13-29(20,26)27)18-17(22)12-9-15(24-18)8-5-14-6-10-16(28-4)11-7-14/h6-7,9-12H,13H2,1-4H3,(H2,23,25)	UTMBRSJWJLJSRI-UHFFFAOYSA-N	259206	US9499502, 31	Beta-secretase 2		 5000						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259206&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89095419	350083904							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451638	C[C@@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1nc(ccc1F)C#Cc1ccc(F)cc1	InChI=1S/C20H19F2N3O2S/c1-19(2)18(23)25-20(3,12-28(19,26)27)17-16(22)11-10-15(24-17)9-6-13-4-7-14(21)8-5-13/h4-5,7-8,10-11H,12H2,1-3H3,(H2,23,25)/t20-/m1/s1	SECNHBCABZATFC-HXUWFJFHSA-N	259207	US9499502, 31a	Beta-secretase 2		 5000						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259207&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131953977	350083905							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451639	CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1cc(ccc1F)N1Cc2cc(Br)ccc2C1=O	InChI=1S/C21H21BrFN3O3S/c1-20(2)19(24)25-21(3,11-30(20,28)29)16-9-14(5-7-17(16)23)26-10-12-8-13(22)4-6-15(12)18(26)27/h4-9H,10-11H2,1-3H3,(H2,24,25)/t21-/m0/s1	SERIDBXYYFBUPP-NRFANRHFSA-N	259230	US9499502, 35	Beta-secretase 2		 779						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259230&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094934	350083928							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451640	C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1sc(cc1Cl)N1Cc2cc(F)ccc2C1=O	InChI=1S/C19H19ClFN3O3S2/c1-18(2)17(22)23-19(3,9-29(18,26)27)15-13(20)7-14(28-15)24-8-10-6-11(21)4-5-12(10)16(24)25/h4-7H,8-9H2,1-3H3,(H2,22,23)/t19-/m0/s1	JWGWNLUHXMABSD-IBGZPJMESA-N	259231	US9499502, 35a	Beta-secretase 2		 1400						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259231&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89094935	350083929							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
451641	CC(=O)c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C13H17ClN2O3S2/c1-7(17)9-5-8(14)10(20-9)13(4)6-21(18,19)12(2,3)11(15)16-13/h5H,6H2,1-4H3,(H2,15,16)/t13-/m0/s1	SGVGFWMLXSXUIM-ZDUSSCGKSA-N	259232	US9499502, 36	Beta-secretase 2		 1200						5	30.00 C	US Patent		10.7270/Q2BV7FJJ		aid1803645	US9499502	Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Bennett, CE; Gilbert, EJ; Scott, JD; Yu, Y; Peng, X	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259232&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66562150	350083930							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447894	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCN(Cc3ccccc3)C2)S1(=O)=O	InChI=1S/C27H28F2N6O3S/c1-26(21-14-20(9-10-22(21)29)32-24(36)23-11-8-19(28)15-31-23)27(39(37,38)34(2)25(30)33-26)12-13-35(17-27)16-18-6-4-3-5-7-18/h3-11,14-15H,12-13,16-17H2,1-2H3,(H2,30,33)(H,32,36)/t26-,27?/m1/s1	UCGWTFCDJKLPAQ-AVJYQCBHSA-N	256730	US9489013, 1	Beta-secretase 2		 4.5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256730	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256730&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287652	347916532							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447895	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCNC2)S1(=O)=O	InChI=1S/C20H22F2N6O3S/c1-19(20(7-8-24-11-20)32(30,31)28(2)18(23)27-19)14-9-13(4-5-15(14)22)26-17(29)16-6-3-12(21)10-25-16/h3-6,9-10,24H,7-8,11H2,1-2H3,(H2,23,27)(H,26,29)/t19-,20?/m1/s1	NUXOWSPESJOYSN-FIWHBWSRSA-N	256731	US9489013, 2	Beta-secretase 2		 30						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287653	347916533							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447896	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCN(C2)S(C)(=O)=O)S1(=O)=O	InChI=1S/C21H24F2N6O5S2/c1-20(15-10-14(5-6-16(15)23)26-18(30)17-7-4-13(22)11-25-17)21(8-9-29(12-21)35(3,31)32)36(33,34)28(2)19(24)27-20/h4-7,10-11H,8-9,12H2,1-3H3,(H2,24,27)(H,26,30)/t20-,21?/m1/s1	MMNYGNJXLCCNNR-VQCQRNETSA-N	256732	US9489013, 3	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256732&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287654	347916534							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447897	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCN(C2)C(C)=O)S1(=O)=O	InChI=1S/C22H24F2N6O4S/c1-13(31)30-9-8-22(12-30)21(2,28-20(25)29(3)35(22,33)34)16-10-15(5-6-17(16)24)27-19(32)18-7-4-14(23)11-26-18/h4-7,10-11H,8-9,12H2,1-3H3,(H2,25,28)(H,27,32)/t21-,22?/m1/s1	KEIKKXYGXIIUCK-ZMFCMNQTSA-N	256733	US9489013, 4	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256733&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287655	347916535							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447898	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCN(C2)C(=O)C2CC2)S1(=O)=O	InChI=1S/C24H26F2N6O4S/c1-23(17-11-16(6-7-18(17)26)29-20(33)19-8-5-15(25)12-28-19)24(37(35,36)31(2)22(27)30-23)9-10-32(13-24)21(34)14-3-4-14/h5-8,11-12,14H,3-4,9-10,13H2,1-2H3,(H2,27,30)(H,29,33)/t23-,24?/m1/s1	BNYKBTUCVAJFLG-MIHMCVIASA-N	256734	US9489013, 5	Beta-secretase 2		 3.1						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256734&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287656	347916536							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447899	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCN(C2)C(=O)CC2CC2)S1(=O)=O	InChI=1S/C25H28F2N6O4S/c1-24(18-12-17(6-7-19(18)27)30-22(35)20-8-5-16(26)13-29-20)25(38(36,37)32(2)23(28)31-24)9-10-33(14-25)21(34)11-15-3-4-15/h5-8,12-13,15H,3-4,9-11,14H2,1-2H3,(H2,28,31)(H,30,35)/t24-,25?/m1/s1	TUKOIDTVYQNYBI-IKOFQBKESA-N	256735	US9489013, 6	Beta-secretase 2		 5.2						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256735	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256735&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287801	347916537							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447900	CC(C)CC(=O)N1CCC2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C25H30F2N6O4S/c1-15(2)11-21(34)33-10-9-25(14-33)24(3,31-23(28)32(4)38(25,36)37)18-12-17(6-7-19(18)27)30-22(35)20-8-5-16(26)13-29-20/h5-8,12-13,15H,9-11,14H2,1-4H3,(H2,28,31)(H,30,35)/t24-,25?/m1/s1	AZXYZHJOEKIZTQ-IKOFQBKESA-N	256736	US9489013, 7	Beta-secretase 2		 5.7						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256736&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287802	347916538							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447901	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(Cc2cscn2)C1	InChI=1S/C25H28FN7O4S2/c1-24(19-10-16(4-6-20(19)26)30-22(34)21-7-5-18(37-3)11-28-21)25(39(35,36)32(2)23(27)31-24)8-9-33(14-25)12-17-13-38-15-29-17/h4-7,10-11,13,15H,8-9,12,14H2,1-3H3,(H2,27,31)(H,30,34)/t24-,25-/m1/s1	GNJDAAGNXLWPPK-JWQCQUIFSA-N	256737	US9489013, 8	Beta-secretase 2		 13						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256737&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287803	347916539							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447902	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(CC2CCOC2)C1	InChI=1S/C26H33FN6O5S/c1-25(20-12-18(4-6-21(20)27)30-23(34)22-7-5-19(37-3)13-29-22)26(39(35,36)32(2)24(28)31-25)9-10-33(16-26)14-17-8-11-38-15-17/h4-7,12-13,17H,8-11,14-16H2,1-3H3,(H2,28,31)(H,30,34)/t17?,25-,26-/m1/s1	GSBBJPLUKMFSQD-MJXMXGAKSA-N	256738	US9489013, 9	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256738&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287804	347916540							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447903	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(Cc2ccccn2)C1	InChI=1S/C27H30FN7O4S/c1-26(21-14-18(7-9-22(21)28)32-24(36)23-10-8-20(39-3)15-31-23)27(40(37,38)34(2)25(29)33-26)11-13-35(17-27)16-19-6-4-5-12-30-19/h4-10,12,14-15H,11,13,16-17H2,1-3H3,(H2,29,33)(H,32,36)/t26-,27-/m1/s1	UMIXHCSZXKINFB-KAYWLYCHSA-N	256739	US9489013, 10	Beta-secretase 2		 13						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256739&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287805	347916541							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447904	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(Cc2cccnc2)C1	InChI=1S/C27H30FN7O4S/c1-26(21-13-19(6-8-22(21)28)32-24(36)23-9-7-20(39-3)15-31-23)27(40(37,38)34(2)25(29)33-26)10-12-35(17-27)16-18-5-4-11-30-14-18/h4-9,11,13-15H,10,12,16-17H2,1-3H3,(H2,29,33)(H,32,36)/t26-,27-/m1/s1	BFQREBABDXGEMX-KAYWLYCHSA-N	256740	US9489013, 11	Beta-secretase 2		 12						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256740	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256740&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287947	347916542							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447905	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(CC2CC2)C1	InChI=1S/C25H31FN6O4S/c1-24(19-12-17(6-8-20(19)26)29-22(33)21-9-7-18(36-3)13-28-21)25(37(34,35)31(2)23(27)30-24)10-11-32(15-25)14-16-4-5-16/h6-9,12-13,16H,4-5,10-11,14-15H2,1-3H3,(H2,27,30)(H,29,33)/t24-,25-/m1/s1	AMHKQZGSNKYDKI-JWQCQUIFSA-N	256741	US9489013, 12	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256741&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287948	347916543							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447906	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(CCC(F)(F)F)C1	InChI=1S/C24H28F4N6O4S/c1-22(17-12-15(4-6-18(17)25)31-20(35)19-7-5-16(38-3)13-30-19)23(39(36,37)33(2)21(29)32-22)8-10-34(14-23)11-9-24(26,27)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,29,32)(H,31,35)/t22-,23-/m1/s1	FCNSILZIDHFQQL-DHIUTWEWSA-N	256742	US9489013, 13	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256742&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			75203540	347916544							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447907	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(Cc2cnco2)C1	InChI=1S/C25H28FN7O5S/c1-24(19-10-16(4-6-20(19)26)30-22(34)21-7-5-17(37-3)12-29-21)25(39(35,36)32(2)23(27)31-24)8-9-33(14-25)13-18-11-28-15-38-18/h4-7,10-12,15H,8-9,13-14H2,1-3H3,(H2,27,31)(H,30,34)/t24-,25-/m1/s1	PJWXZIOOLPIBQH-JWQCQUIFSA-N	256743	US9489013, 14	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256743	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256743&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287949	347916545							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447908	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(Cc2cncnc2)C1	InChI=1S/C26H29FN8O4S/c1-25(20-10-18(4-6-21(20)27)32-23(36)22-7-5-19(39-3)13-31-22)26(40(37,38)34(2)24(28)33-25)8-9-35(15-26)14-17-11-29-16-30-12-17/h4-7,10-13,16H,8-9,14-15H2,1-3H3,(H2,28,33)(H,32,36)/t25-,26-/m1/s1	BBRHEFOZBPTFIY-CLJLJLNGSA-N	256744	US9489013, 15	Beta-secretase 2		 17						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256744	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256744&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287950	347916546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447909	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(Cc2cnn(C)c2)C1	InChI=1S/C26H31FN8O4S/c1-25(20-11-18(5-7-21(20)27)31-23(36)22-8-6-19(39-4)13-29-22)26(40(37,38)34(3)24(28)32-25)9-10-35(16-26)15-17-12-30-33(2)14-17/h5-8,11-14H,9-10,15-16H2,1-4H3,(H2,28,32)(H,31,36)/t25-,26-/m1/s1	WNHOUMACKAGPIW-CLJLJLNGSA-N	256745	US9489013, 16	Beta-secretase 2		 26						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256745&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287951	347916547							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447910	COC1CC(CN2CC[C@@]3(C2)[C@](C)(NC(=N)N(C)S3(=O)=O)c2cc(NC(=O)c3ccc(OC)cn3)ccc2F)C1	InChI=1S/C27H35FN6O5S/c1-26(21-13-18(5-7-22(21)28)31-24(35)23-8-6-19(38-3)14-30-23)27(40(36,37)33(2)25(29)32-26)9-10-34(16-27)15-17-11-20(12-17)39-4/h5-8,13-14,17,20H,9-12,15-16H2,1-4H3,(H2,29,32)(H,31,35)/t17?,20?,26-,27-/m1/s1	DGZLNBXDRKEZBW-LOKIQYQMSA-N	256746	US9489013, 17	Beta-secretase 2		 21						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256746&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285700	347916548							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447911	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(Cc2cocn2)C1	InChI=1S/C25H28FN7O5S/c1-24(19-10-16(4-6-20(19)26)30-22(34)21-7-5-18(37-3)11-28-21)25(39(35,36)32(2)23(27)31-24)8-9-33(14-25)12-17-13-38-15-29-17/h4-7,10-11,13,15H,8-9,12,14H2,1-3H3,(H2,27,31)(H,30,34)/t24-,25+/m1/s1	WZOJBMUQJGTZIJ-RPBOFIJWSA-N	256747	US9489013, 18	Beta-secretase 2		 158						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256747&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285701	347916549							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447912	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(Cc2cscn2)C1	InChI=1S/C25H28FN7O4S2/c1-24(19-10-16(4-6-20(19)26)30-22(34)21-7-5-18(37-3)11-28-21)25(39(35,36)32(2)23(27)31-24)8-9-33(14-25)12-17-13-38-15-29-17/h4-7,10-11,13,15H,8-9,12,14H2,1-3H3,(H2,27,31)(H,30,34)/t24-,25+/m1/s1	GNJDAAGNXLWPPK-RPBOFIJWSA-N	256748	US9489013, 19	Beta-secretase 2		 70						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256748&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285702	347916550							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447913	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(CC2CCOC2)C1	InChI=1S/C26H33FN6O5S/c1-25(20-12-18(4-6-21(20)27)30-23(34)22-7-5-19(37-3)13-29-22)26(39(35,36)32(2)24(28)31-25)9-10-33(16-26)14-17-8-11-38-15-17/h4-7,12-13,17H,8-11,14-16H2,1-3H3,(H2,28,31)(H,30,34)/t17?,25-,26+/m1/s1	GSBBJPLUKMFSQD-IBSSSRLASA-N	256749	US9489013, 20	Beta-secretase 2		 188						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256749	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256749&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285703	347916551							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447914	COC1CC(CN2CC[C@]3(C2)[C@](C)(NC(=N)N(C)S3(=O)=O)c2cc(NC(=O)c3ccc(OC)cn3)ccc2F)C1	InChI=1S/C27H35FN6O5S/c1-26(21-13-18(5-7-22(21)28)31-24(35)23-8-6-19(38-3)14-30-23)27(40(36,37)33(2)25(29)32-26)9-10-34(16-27)15-17-11-20(12-17)39-4/h5-8,13-14,17,20H,9-12,15-16H2,1-4H3,(H2,29,32)(H,31,35)/t17?,20?,26-,27+/m1/s1	DGZLNBXDRKEZBW-HRBFUPENSA-N	256750	US9489013, 21	Beta-secretase 2		 201						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256750&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285704	347916552							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447915	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(Cc2ccccn2)C1	InChI=1S/C27H30FN7O4S/c1-26(21-14-18(7-9-22(21)28)32-24(36)23-10-8-20(39-3)15-31-23)27(40(37,38)34(2)25(29)33-26)11-13-35(17-27)16-19-6-4-5-12-30-19/h4-10,12,14-15H,11,13,16-17H2,1-3H3,(H2,29,33)(H,32,36)/t26-,27+/m1/s1	UMIXHCSZXKINFB-SXOMAYOGSA-N	256751	US9489013, 22	Beta-secretase 2		 79						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256751&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285859	347916553							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447916	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(Cc2cccnc2)C1	InChI=1S/C27H30FN7O4S/c1-26(21-13-19(6-8-22(21)28)32-24(36)23-9-7-20(39-3)15-31-23)27(40(37,38)34(2)25(29)33-26)10-12-35(17-27)16-18-5-4-11-30-14-18/h4-9,11,13-15H,10,12,16-17H2,1-3H3,(H2,29,33)(H,32,36)/t26-,27+/m1/s1	BFQREBABDXGEMX-SXOMAYOGSA-N	256752	US9489013, 23	Beta-secretase 2		 142						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256752&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285860	347916554							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447917	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(CC2CC2)C1	InChI=1S/C25H31FN6O4S/c1-24(19-12-17(6-8-20(19)26)29-22(33)21-9-7-18(36-3)13-28-21)25(37(34,35)31(2)23(27)30-24)10-11-32(15-25)14-16-4-5-16/h6-9,12-13,16H,4-5,10-11,14-15H2,1-3H3,(H2,27,30)(H,29,33)/t24-,25+/m1/s1	AMHKQZGSNKYDKI-RPBOFIJWSA-N	256753	US9489013, 24	Beta-secretase 2		 128						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256753&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285861	347916555							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447918	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(CCC(F)(F)F)C1	InChI=1S/C24H28F4N6O4S/c1-22(17-12-15(4-6-18(17)25)31-20(35)19-7-5-16(38-3)13-30-19)23(39(36,37)33(2)21(29)32-22)8-10-34(14-23)11-9-24(26,27)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,29,32)(H,31,35)/t22-,23+/m1/s1	FCNSILZIDHFQQL-PKTZIBPZSA-N	256754	US9489013, 25	Beta-secretase 2		 52						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256754&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285862	347916556							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447919	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(Cc2cncnc2)C1	InChI=1S/C26H29FN8O4S/c1-25(20-10-18(4-6-21(20)27)32-23(36)22-7-5-19(39-3)13-31-22)26(40(37,38)34(2)24(28)33-25)8-9-35(15-26)14-17-11-29-16-30-12-17/h4-7,10-13,16H,8-9,14-15H2,1-3H3,(H2,28,33)(H,32,36)/t25-,26+/m1/s1	BBRHEFOZBPTFIY-FTJBHMTQSA-N	256755	US9489013, 26	Beta-secretase 2		 329						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256755	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256755&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285863	347916557							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447920	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(Cc2cnn(C)c2)C1	InChI=1S/C26H31FN8O4S/c1-25(20-11-18(5-7-21(20)27)31-23(36)22-8-6-19(39-4)13-29-22)26(40(37,38)34(3)24(28)32-25)9-10-35(16-26)15-17-12-30-33(2)14-17/h5-8,11-14H,9-10,15-16H2,1-4H3,(H2,28,32)(H,31,36)/t25-,26+/m1/s1	WNHOUMACKAGPIW-FTJBHMTQSA-N	256756	US9489013, 27	Beta-secretase 2		 388						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256756&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286009	347916558							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447921	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(Cc2cnco2)C1	InChI=1S/C25H28FN7O5S/c1-24(19-10-16(4-6-20(19)26)30-22(34)21-7-5-17(37-3)12-29-21)25(39(35,36)32(2)23(27)31-24)8-9-33(14-25)13-18-11-28-15-38-18/h4-7,10-12,15H,8-9,13-14H2,1-3H3,(H2,27,31)(H,30,34)/t24-,25+/m1/s1	PJWXZIOOLPIBQH-RPBOFIJWSA-N	256757	US9489013, 28	Beta-secretase 2		 237						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256757	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256757&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286010	347916559							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447922	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3ccncc3)C2)S1(=O)=O	InChI=1S/C26H27F2N7O3S/c1-25(20-13-19(4-5-21(20)28)32-23(36)22-6-3-18(27)14-31-22)26(39(37,38)34(2)24(29)33-25)9-12-35(16-26)15-17-7-10-30-11-8-17/h3-8,10-11,13-14H,9,12,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26-/m1/s1	IWZDPRSVPNHWSX-CLJLJLNGSA-N	256758	US9489013, 29	Beta-secretase 2		 9						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256758	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256758&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286011	347916560							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447923	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3cnco3)C2)S1(=O)=O	InChI=1S/C24H25F2N7O4S/c1-23(18-9-16(4-5-19(18)26)30-21(34)20-6-3-15(25)10-29-20)24(38(35,36)32(2)22(27)31-23)7-8-33(13-24)12-17-11-28-14-37-17/h3-6,9-11,14H,7-8,12-13H2,1-2H3,(H2,27,31)(H,30,34)/t23-,24-/m1/s1	PCLGAKHIUADDGN-DNQXCXABSA-N	256759	US9489013, 30	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256759&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286012	347916561							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447924	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(CC3CC3)C2)S1(=O)=O	InChI=1S/C24H28F2N6O3S/c1-23(18-11-17(6-7-19(18)26)29-21(33)20-8-5-16(25)12-28-20)24(36(34,35)31(2)22(27)30-23)9-10-32(14-24)13-15-3-4-15/h5-8,11-12,15H,3-4,9-10,13-14H2,1-2H3,(H2,27,30)(H,29,33)/t23-,24-/m1/s1	TYNRGDMOULFXPY-DNQXCXABSA-N	256760	US9489013, 31	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256760	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256760&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286013	347916562							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447925	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(CC3CCOC3)C2)S1(=O)=O	InChI=1S/C25H30F2N6O4S/c1-24(19-11-18(4-5-20(19)27)30-22(34)21-6-3-17(26)12-29-21)25(38(35,36)32(2)23(28)31-24)8-9-33(15-25)13-16-7-10-37-14-16/h3-6,11-12,16H,7-10,13-15H2,1-2H3,(H2,28,31)(H,30,34)/t16?,24-,25-/m1/s1	NGPHTVXXKPWBFE-GWIGBITDSA-N	256761	US9489013, 32	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256761&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286157	347916563							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447926	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3cscn3)C2)S1(=O)=O	InChI=1S/C24H25F2N7O3S2/c1-23(18-9-16(4-5-19(18)26)30-21(34)20-6-3-15(25)10-28-20)24(38(35,36)32(2)22(27)31-23)7-8-33(13-24)11-17-12-37-14-29-17/h3-6,9-10,12,14H,7-8,11,13H2,1-2H3,(H2,27,31)(H,30,34)/t23-,24-/m1/s1	NYLCKSMOJRUAMS-DNQXCXABSA-N	256762	US9489013, 33	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256762	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256762&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286158	347916564							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447927	COC1CC(CN2CC[C@@]3(C2)[C@](C)(NC(=N)N(C)S3(=O)=O)c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C1	InChI=1S/C26H32F2N6O4S/c1-25(20-12-18(5-6-21(20)28)31-23(35)22-7-4-17(27)13-30-22)26(39(36,37)33(2)24(29)32-25)8-9-34(15-26)14-16-10-19(11-16)38-3/h4-7,12-13,16,19H,8-11,14-15H2,1-3H3,(H2,29,32)(H,31,35)/t16?,19?,25-,26-/m1/s1	MMRQPCLPZAITEM-ONQCARMESA-N	256763	US9489013, 34	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256763	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256763&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286159	347916565							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447928	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3cccnc3)C2)S1(=O)=O	InChI=1S/C26H27F2N7O3S/c1-25(20-12-19(6-7-21(20)28)32-23(36)22-8-5-18(27)14-31-22)26(39(37,38)34(2)24(29)33-25)9-11-35(16-26)15-17-4-3-10-30-13-17/h3-8,10,12-14H,9,11,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26-/m1/s1	FLBGWESVICALMG-CLJLJLNGSA-N	256764	US9489013, 35	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256764	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256764&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286160	347916566							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447929	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(CCC(F)(F)F)C2)S1(=O)=O	InChI=1S/C23H25F5N6O3S/c1-21(16-11-15(4-5-17(16)25)31-19(35)18-6-3-14(24)12-30-18)22(38(36,37)33(2)20(29)32-21)7-9-34(13-22)10-8-23(26,27)28/h3-6,11-12H,7-10,13H2,1-2H3,(H2,29,32)(H,31,35)/t21-,22-/m1/s1	SDRRMAFKXWCTGV-FGZHOGPDSA-N	256765	US9489013, 36	Beta-secretase 2		 1						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256765&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286161	347916567							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447930	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3cocn3)C2)S1(=O)=O	InChI=1S/C24H25F2N7O4S/c1-23(18-9-16(4-5-19(18)26)30-21(34)20-6-3-15(25)10-28-20)24(38(35,36)32(2)22(27)31-23)7-8-33(13-24)11-17-12-37-14-29-17/h3-6,9-10,12,14H,7-8,11,13H2,1-2H3,(H2,27,31)(H,30,34)/t23-,24-/m1/s1	WBMOBCSTLLKLOA-DNQXCXABSA-N	256766	US9489013, 37	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256766&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286309	347916568							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447931	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3cncnc3)C2)S1(=O)=O	InChI=1S/C25H26F2N8O3S/c1-24(19-9-18(4-5-20(19)27)32-22(36)21-6-3-17(26)12-31-21)25(39(37,38)34(2)23(28)33-24)7-8-35(14-25)13-16-10-29-15-30-11-16/h3-6,9-12,15H,7-8,13-14H2,1-2H3,(H2,28,33)(H,32,36)/t24-,25-/m1/s1	DVRPTMNWPDAQDY-JWQCQUIFSA-N	256767	US9489013, 38	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256767&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286310	347916569							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447932	CCCCN1CC[C@@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H30F2N6O3S/c1-4-5-11-32-12-10-24(15-32)23(2,30-22(27)31(3)36(24,34)35)18-13-17(7-8-19(18)26)29-21(33)20-9-6-16(25)14-28-20/h6-9,13-14H,4-5,10-12,15H2,1-3H3,(H2,27,30)(H,29,33)/t23-,24-/m1/s1	ODMXWBIQPHUQGR-DNQXCXABSA-N	256768	US9489013, 39	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256768&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286311	347916570							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447933	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3cnn(C)c3)C2)S1(=O)=O	InChI=1S/C25H28F2N8O3S/c1-24(19-10-18(5-6-20(19)27)31-22(36)21-7-4-17(26)12-29-21)25(39(37,38)34(3)23(28)32-24)8-9-35(15-25)14-16-11-30-33(2)13-16/h4-7,10-13H,8-9,14-15H2,1-3H3,(H2,28,32)(H,31,36)/t24-,25-/m1/s1	FCBMFSTVCQDNMI-JWQCQUIFSA-N	256769	US9489013, 40	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256769	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256769&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286312	347916571							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447934	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(Cc3ccccn3)C2)S1(=O)=O	InChI=1S/C26H27F2N7O3S/c1-25(20-13-18(7-8-21(20)28)32-23(36)22-9-6-17(27)14-31-22)26(39(37,38)34(2)24(29)33-25)10-12-35(16-26)15-19-5-3-4-11-30-19/h3-9,11,13-14H,10,12,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26-/m1/s1	JYBYZESYNAYNQK-CLJLJLNGSA-N	256770	US9489013, 41	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256770&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286313	347916572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447935	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3cscn3)C2)S1(=O)=O	InChI=1S/C24H25F2N7O3S2/c1-23(18-9-16(4-5-19(18)26)30-21(34)20-6-3-15(25)10-28-20)24(38(35,36)32(2)22(27)31-23)7-8-33(13-24)11-17-12-37-14-29-17/h3-6,9-10,12,14H,7-8,11,13H2,1-2H3,(H2,27,31)(H,30,34)/t23-,24+/m1/s1	NYLCKSMOJRUAMS-RPWUZVMVSA-N	256771	US9489013, 42	Beta-secretase 2		 25						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256771&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286462	347916573							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447936	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(CC3CCOC3)C2)S1(=O)=O	InChI=1S/C25H30F2N6O4S/c1-24(19-11-18(4-5-20(19)27)30-22(34)21-6-3-17(26)12-29-21)25(38(35,36)32(2)23(28)31-24)8-9-33(15-25)13-16-7-10-37-14-16/h3-6,11-12,16H,7-10,13-15H2,1-2H3,(H2,28,31)(H,30,34)/t16?,24-,25+/m1/s1	NGPHTVXXKPWBFE-DTBCUYFASA-N	256772	US9489013, 43	Beta-secretase 2		 72						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256772	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256772&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286463	347916574							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447937	COC1CC(CN2CC[C@]3(C2)[C@](C)(NC(=N)N(C)S3(=O)=O)c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C1	InChI=1S/C26H32F2N6O4S/c1-25(20-12-18(5-6-21(20)28)31-23(35)22-7-4-17(27)13-30-22)26(39(36,37)33(2)24(29)32-25)8-9-34(15-26)14-16-10-19(11-16)38-3/h4-7,12-13,16,19H,8-11,14-15H2,1-3H3,(H2,29,32)(H,31,35)/t16?,19?,25-,26+/m1/s1	MMRQPCLPZAITEM-UNVXIPDISA-N	256773	US9489013, 44	Beta-secretase 2		 52						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256773&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286464	347916575							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447938	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3ccccn3)C2)S1(=O)=O	InChI=1S/C26H27F2N7O3S/c1-25(20-13-18(7-8-21(20)28)32-23(36)22-9-6-17(27)14-31-22)26(39(37,38)34(2)24(29)33-25)10-12-35(16-26)15-19-5-3-4-11-30-19/h3-9,11,13-14H,10,12,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26+/m1/s1	JYBYZESYNAYNQK-FTJBHMTQSA-N	256774	US9489013, 45	Beta-secretase 2		 23						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256774&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286465	347916576							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447939	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3cccnc3)C2)S1(=O)=O	InChI=1S/C26H27F2N7O3S/c1-25(20-12-19(6-7-21(20)28)32-23(36)22-8-5-18(27)14-31-22)26(39(37,38)34(2)24(29)33-25)9-11-35(16-26)15-17-4-3-10-30-13-17/h3-8,10,12-14H,9,11,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26+/m1/s1	FLBGWESVICALMG-FTJBHMTQSA-N	256775	US9489013, 46	Beta-secretase 2		 40						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256775&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286466	347916577							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447940	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(CC3CC3)C2)S1(=O)=O	InChI=1S/C24H28F2N6O3S/c1-23(18-11-17(6-7-19(18)26)29-21(33)20-8-5-16(25)12-28-20)24(36(34,35)31(2)22(27)30-23)9-10-32(14-24)13-15-3-4-15/h5-8,11-12,15H,3-4,9-10,13-14H2,1-2H3,(H2,27,30)(H,29,33)/t23-,24+/m1/s1	TYNRGDMOULFXPY-RPWUZVMVSA-N	256776	US9489013, 47	Beta-secretase 2		 51						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256776&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286609	347916578							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447941	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(CCC(F)(F)F)C2)S1(=O)=O	InChI=1S/C23H25F5N6O3S/c1-21(16-11-15(4-5-17(16)25)31-19(35)18-6-3-14(24)12-30-18)22(38(36,37)33(2)20(29)32-21)7-9-34(13-22)10-8-23(26,27)28/h3-6,11-12H,7-10,13H2,1-2H3,(H2,29,32)(H,31,35)/t21-,22+/m1/s1	SDRRMAFKXWCTGV-YADHBBJMSA-N	256777	US9489013, 48	Beta-secretase 2		 14						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256777&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286610	347916579							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447942	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3cocn3)C2)S1(=O)=O	InChI=1S/C24H25F2N7O4S/c1-23(18-9-16(4-5-19(18)26)30-21(34)20-6-3-15(25)10-28-20)24(38(35,36)32(2)22(27)31-23)7-8-33(13-24)11-17-12-37-14-29-17/h3-6,9-10,12,14H,7-8,11,13H2,1-2H3,(H2,27,31)(H,30,34)/t23-,24+/m1/s1	WBMOBCSTLLKLOA-RPWUZVMVSA-N	256778	US9489013, 49	Beta-secretase 2		 21						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256778&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286611	347916580							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447943	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3cncnc3)C2)S1(=O)=O	InChI=1S/C25H26F2N8O3S/c1-24(19-9-18(4-5-20(19)27)32-22(36)21-6-3-17(26)12-31-21)25(39(37,38)34(2)23(28)33-24)7-8-35(14-25)13-16-10-29-15-30-11-16/h3-6,9-12,15H,7-8,13-14H2,1-2H3,(H2,28,33)(H,32,36)/t24-,25+/m1/s1	DVRPTMNWPDAQDY-RPBOFIJWSA-N	256779	US9489013, 50	Beta-secretase 2		 77						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256779&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286612	347916581							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447944	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3cnn(C)c3)C2)S1(=O)=O	InChI=1S/C25H28F2N8O3S/c1-24(19-10-18(5-6-20(19)27)31-22(36)21-7-4-17(26)12-29-21)25(39(37,38)34(3)23(28)32-24)8-9-35(15-25)14-16-11-30-33(2)13-16/h4-7,10-13H,8-9,14-15H2,1-3H3,(H2,28,32)(H,31,36)/t24-,25+/m1/s1	FCBMFSTVCQDNMI-RPBOFIJWSA-N	256780	US9489013, 51	Beta-secretase 2		 184						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256780	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256780&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286613	347916582							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447945	CCCCN1CC[C@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H30F2N6O3S/c1-4-5-11-32-12-10-24(15-32)23(2,30-22(27)31(3)36(24,34)35)18-13-17(7-8-19(18)26)29-21(33)20-9-6-16(25)14-28-20/h6-9,13-14H,4-5,10-12,15H2,1-3H3,(H2,27,30)(H,29,33)/t23-,24+/m1/s1	ODMXWBIQPHUQGR-RPWUZVMVSA-N	256781	US9489013, 52	Beta-secretase 2		 61						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256781&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286760	347916583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447946	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3ccncc3)C2)S1(=O)=O	InChI=1S/C26H27F2N7O3S/c1-25(20-13-19(4-5-21(20)28)32-23(36)22-6-3-18(27)14-31-22)26(39(37,38)34(2)24(29)33-25)9-12-35(16-26)15-17-7-10-30-11-8-17/h3-8,10-11,13-14H,9,12,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26+/m1/s1	IWZDPRSVPNHWSX-FTJBHMTQSA-N	256782	US9489013, 53	Beta-secretase 2		 61						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256782&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286761	347916584							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447947	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(Cc3cnco3)C2)S1(=O)=O	InChI=1S/C24H25F2N7O4S/c1-23(18-9-16(4-5-19(18)26)30-21(34)20-6-3-15(25)10-29-20)24(38(35,36)32(2)22(27)31-23)7-8-33(13-24)12-17-11-28-14-37-17/h3-6,9-11,14H,7-8,12-13H2,1-2H3,(H2,27,31)(H,30,34)/t23-,24+/m1/s1	PCLGAKHIUADDGN-RPWUZVMVSA-N	256783	US9489013, 54	Beta-secretase 2		 74						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286762	347916585							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447948	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(C1)S(C)(=O)=O	InChI=1S/C22H27FN6O6S2/c1-21(22(9-10-29(13-22)36(4,31)32)37(33,34)28(2)20(24)27-21)16-11-14(5-7-17(16)23)26-19(30)18-8-6-15(35-3)12-25-18/h5-8,11-12H,9-10,13H2,1-4H3,(H2,24,27)(H,26,30)/t21-,22-/m1/s1	IDMRKUMLFXTUHG-FGZHOGPDSA-N	256784	US9489013, 55	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256784&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286763	347916586							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447949	CCS(=O)(=O)N1CC[C@@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(OC)cn2)ccc1F	InChI=1S/C23H29FN6O6S2/c1-5-37(32,33)30-11-10-23(14-30)22(2,28-21(25)29(3)38(23,34)35)17-12-15(6-8-18(17)24)27-20(31)19-9-7-16(36-4)13-26-19/h6-9,12-13H,5,10-11,14H2,1-4H3,(H2,25,28)(H,27,31)/t22-,23-/m1/s1	JTOXHWAXERLMCJ-DHIUTWEWSA-N	256785	US9489013, 56	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256785&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286764	347916587							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447950	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(C1)S(=O)(=O)CC(C)C	InChI=1S/C25H33FN6O6S2/c1-16(2)14-39(34,35)32-11-10-25(15-32)24(3,30-23(27)31(4)40(25,36)37)19-12-17(6-8-20(19)26)29-22(33)21-9-7-18(38-5)13-28-21/h6-9,12-13,16H,10-11,14-15H2,1-5H3,(H2,27,30)(H,29,33)/t24-,25-/m1/s1	SEENGVHYCRGRAD-JWQCQUIFSA-N	256786	US9489013, 57	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256786&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76286916	347916588							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447951	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(C1)S(=O)(=O)c1ccc(F)cc1	InChI=1S/C27H28F2N6O6S2/c1-26(21-14-18(6-10-22(21)29)32-24(36)23-11-7-19(41-3)15-31-23)27(43(39,40)34(2)25(30)33-26)12-13-35(16-27)42(37,38)20-8-4-17(28)5-9-20/h4-11,14-15H,12-13,16H2,1-3H3,(H2,30,33)(H,32,36)/t26-,27-/m1/s1	MLWKNTQDGZTMCA-KAYWLYCHSA-N	256787	US9489013, 58	Beta-secretase 2		 20						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256787&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287367	347916589							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447952	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(C1)S(=O)(=O)c1ccccc1	InChI=1S/C27H29FN6O6S2/c1-26(21-15-18(9-11-22(21)28)31-24(35)23-12-10-19(40-3)16-30-23)27(42(38,39)33(2)25(29)32-26)13-14-34(17-27)41(36,37)20-7-5-4-6-8-20/h4-12,15-16H,13-14,17H2,1-3H3,(H2,29,32)(H,31,35)/t26-,27-/m1/s1	OHJQIORTAHXAAP-KAYWLYCHSA-N	256788	US9489013, 59	Beta-secretase 2		 16						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256788&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674590	347916590							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447953	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(C1)S(=O)(=O)C1CC1	InChI=1S/C24H29FN6O6S2/c1-23(18-12-15(4-8-19(18)25)28-21(32)20-9-5-16(37-3)13-27-20)24(39(35,36)30(2)22(26)29-23)10-11-31(14-24)38(33,34)17-6-7-17/h4-5,8-9,12-13,17H,6-7,10-11,14H2,1-3H3,(H2,26,29)(H,28,32)/t23-,24-/m1/s1	MDOQKNPBFXGYEG-DNQXCXABSA-N	256789	US9489013, 60	Beta-secretase 2		 4						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256789&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674587	347916591							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447954	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(C1)S(=O)(=O)c1cn(C)cn1	InChI=1S/C25H29FN8O6S2/c1-24(18-11-16(5-7-19(18)26)30-22(35)20-8-6-17(40-4)12-28-20)25(42(38,39)33(3)23(27)31-24)9-10-34(14-25)41(36,37)21-13-32(2)15-29-21/h5-8,11-13,15H,9-10,14H2,1-4H3,(H2,27,31)(H,30,35)/t24-,25-/m1/s1	WVNQOOTXZPUPBE-JWQCQUIFSA-N	256790	US9489013, 61	Beta-secretase 2		 38						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256790	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256790&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287067	347916592							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447955	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCN(C1)S(=O)(=O)CC1CCCO1	InChI=1S/C26H33FN6O7S2/c1-25(20-13-17(6-8-21(20)27)30-23(34)22-9-7-18(39-3)14-29-22)26(42(37,38)32(2)24(28)31-25)10-11-33(16-26)41(35,36)15-19-5-4-12-40-19/h6-9,13-14,19H,4-5,10-12,15-16H2,1-3H3,(H2,28,31)(H,30,34)/t19?,25-,26-/m1/s1	GBSFLJSDBPYVRF-VTFDQJKESA-N	256791	US9489013, 62	Beta-secretase 2		 19						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256791&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287068	347916593							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447956	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)c1ccccc1	InChI=1S/C27H29FN6O6S2/c1-26(21-15-18(9-11-22(21)28)31-24(35)23-12-10-19(40-3)16-30-23)27(42(38,39)33(2)25(29)32-26)13-14-34(17-27)41(36,37)20-7-5-4-6-8-20/h4-12,15-16H,13-14,17H2,1-3H3,(H2,29,32)(H,31,35)/t26-,27+/m1/s1	OHJQIORTAHXAAP-SXOMAYOGSA-N	256792	US9489013, 63	Beta-secretase 2		 24						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256792	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256792&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674588	347916594							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447957	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)C1CC1	InChI=1S/C24H29FN6O6S2/c1-23(18-12-15(4-8-19(18)25)28-21(32)20-9-5-16(37-3)13-27-20)24(39(35,36)30(2)22(26)29-23)10-11-31(14-24)38(33,34)17-6-7-17/h4-5,8-9,12-13,17H,6-7,10-11,14H2,1-3H3,(H2,26,29)(H,28,32)/t23-,24+/m1/s1	MDOQKNPBFXGYEG-RPWUZVMVSA-N	256793	US9489013, 64	Beta-secretase 2		 140						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256793	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256793&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674589	347916595							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447958	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)c1cn(C)cn1	InChI=1S/C25H29FN8O6S2/c1-24(18-11-16(5-7-19(18)26)30-22(35)20-8-6-17(40-4)12-28-20)25(42(38,39)33(3)23(27)31-24)9-10-34(14-25)41(36,37)21-13-32(2)15-29-21/h5-8,11-13,15H,9-10,14H2,1-4H3,(H2,27,31)(H,30,35)/t24-,25+/m1/s1	WVNQOOTXZPUPBE-RPBOFIJWSA-N	256794	US9489013, 65	Beta-secretase 2		 68						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256794&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287218	347916596							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447959	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)CC1CCCO1	InChI=1S/C26H33FN6O7S2/c1-25(20-13-17(6-8-21(20)27)30-23(34)22-9-7-18(39-3)14-29-22)26(42(37,38)32(2)24(28)31-25)10-11-33(16-26)41(35,36)15-19-5-4-12-40-19/h6-9,13-14,19H,4-5,10-12,15-16H2,1-3H3,(H2,28,31)(H,30,34)/t19?,25-,26+/m1/s1	GBSFLJSDBPYVRF-WSMRJJHLSA-N	256795	US9489013, 66	Beta-secretase 2		 87						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256795	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256795&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287219	347916597							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447960	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)c1cn[nH]c1			256796	US9489013, 67	Beta-secretase 2		 40						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256796&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287220	347916598							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447961	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(C)(=O)=O	InChI=1S/C22H27FN6O6S2/c1-21(22(9-10-29(13-22)36(4,31)32)37(33,34)28(2)20(24)27-21)16-11-14(5-7-17(16)23)26-19(30)18-8-6-15(35-3)12-25-18/h5-8,11-12H,9-10,13H2,1-4H3,(H2,24,27)(H,26,30)/t21-,22+/m1/s1	IDMRKUMLFXTUHG-YADHBBJMSA-N	256797	US9489013, 68	Beta-secretase 2		 205						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256797	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256797&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287221	347916599							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447962	CCS(=O)(=O)N1CC[C@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(OC)cn2)ccc1F	InChI=1S/C23H29FN6O6S2/c1-5-37(32,33)30-11-10-23(14-30)22(2,28-21(25)29(3)38(23,34)35)17-12-15(6-8-18(17)24)27-20(31)19-9-7-16(36-4)13-26-19/h6-9,12-13H,5,10-11,14H2,1-4H3,(H2,25,28)(H,27,31)/t22-,23+/m1/s1	JTOXHWAXERLMCJ-PKTZIBPZSA-N	256798	US9489013, 69	Beta-secretase 2		 157						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256798&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287222	347916600							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447963	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)CC(C)C	InChI=1S/C25H33FN6O6S2/c1-16(2)14-39(34,35)32-11-10-25(15-32)24(3,30-23(27)31(4)40(25,36)37)19-12-17(6-8-20(19)26)29-22(33)21-9-7-18(38-5)13-28-21/h6-9,12-13,16H,10-11,14-15H2,1-5H3,(H2,27,30)(H,29,33)/t24-,25+/m1/s1	SEENGVHYCRGRAD-RPBOFIJWSA-N	256799	US9489013, 70	Beta-secretase 2		 100						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256799&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287364	347916601							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447964	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)c1ccc(F)cc1	InChI=1S/C27H28F2N6O6S2/c1-26(21-14-18(6-10-22(21)29)32-24(36)23-11-7-19(41-3)15-31-23)27(43(39,40)34(2)25(30)33-26)12-13-35(16-27)42(37,38)20-8-4-17(28)5-9-20/h4-11,14-15H,12-13,16H2,1-3H3,(H2,30,33)(H,32,36)/t26-,27+/m1/s1	MLWKNTQDGZTMCA-SXOMAYOGSA-N	256800	US9489013, 71	Beta-secretase 2		 30						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256800&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287365	347916602							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447965	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@]11CCN(C1)S(=O)(=O)CC(F)(F)F	InChI=1S/C23H26F4N6O6S2/c1-21(16-10-14(4-6-17(16)24)30-19(34)18-7-5-15(39-3)11-29-18)22(41(37,38)32(2)20(28)31-21)8-9-33(12-22)40(35,36)13-23(25,26)27/h4-7,10-11H,8-9,12-13H2,1-3H3,(H2,28,31)(H,30,34)/t21-,22+/m1/s1	PCNUJNJLGDBEBW-YADHBBJMSA-N	256801	US9489013, 72	Beta-secretase 2		 99						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256801&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287366	347916603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447966	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)c2ccc(F)cc2)S1(=O)=O	InChI=1S/C26H25F3N6O5S2/c1-25(20-13-18(6-9-21(20)29)32-23(36)22-10-5-17(28)14-31-22)26(42(39,40)34(2)24(30)33-25)11-12-35(15-26)41(37,38)19-7-3-16(27)4-8-19/h3-10,13-14H,11-12,15H2,1-2H3,(H2,30,33)(H,32,36)/t25-,26-/m1/s1	MMGNGUJAIHDZMD-CLJLJLNGSA-N	256802	US9489013, 73	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256802&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674584	347916604							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447967	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)CC(F)(F)F)S1(=O)=O	InChI=1S/C22H23F5N6O5S2/c1-20(15-9-14(4-5-16(15)24)30-18(34)17-6-3-13(23)10-29-17)21(40(37,38)32(2)19(28)31-20)7-8-33(11-21)39(35,36)12-22(25,26)27/h3-6,9-10H,7-8,11-12H2,1-2H3,(H2,28,31)(H,30,34)/t20-,21-/m1/s1	WGUDWIAWYZNTON-NHCUHLMSSA-N	256803	US9489013, 74	Beta-secretase 2		 4						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256803&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674585	347916605							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447968	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(C)(=O)=O)S1(=O)=O	InChI=1S/C21H24F2N6O5S2/c1-20(15-10-14(5-6-16(15)23)26-18(30)17-7-4-13(22)11-25-17)21(8-9-29(12-21)35(3,31)32)36(33,34)28(2)19(24)27-20/h4-7,10-11H,8-9,12H2,1-3H3,(H2,24,27)(H,26,30)/t20-,21-/m1/s1	MMNYGNJXLCCNNR-NHCUHLMSSA-N	256804	US9489013, 75	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256804&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287508	347916606							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447969	CCS(=O)(=O)N1CC[C@@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H26F2N6O5S2/c1-4-36(32,33)30-10-9-22(13-30)21(2,28-20(25)29(3)37(22,34)35)16-11-15(6-7-17(16)24)27-19(31)18-8-5-14(23)12-26-18/h5-8,11-12H,4,9-10,13H2,1-3H3,(H2,25,28)(H,27,31)/t21-,22-/m1/s1	YCSGFNKKJYBAEN-FGZHOGPDSA-N	256805	US9489013, 76	Beta-secretase 2		 4						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256805&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287509	347916607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447970	CC(C)CS(=O)(=O)N1CC[C@@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H30F2N6O5S2/c1-15(2)13-38(34,35)32-10-9-24(14-32)23(3,30-22(27)31(4)39(24,36)37)18-11-17(6-7-19(18)26)29-21(33)20-8-5-16(25)12-28-20/h5-8,11-12,15H,9-10,13-14H2,1-4H3,(H2,27,30)(H,29,33)/t23-,24-/m1/s1	JKTLLQUTYSVYQN-DNQXCXABSA-N	256806	US9489013, 77	Beta-secretase 2		 3						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256806&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287510	347916608							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447971	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)c2ccccc2)S1(=O)=O	InChI=1S/C26H26F2N6O5S2/c1-25(20-14-18(9-10-21(20)28)31-23(35)22-11-8-17(27)15-30-22)26(41(38,39)33(2)24(29)32-25)12-13-34(16-26)40(36,37)19-6-4-3-5-7-19/h3-11,14-15H,12-13,16H2,1-2H3,(H2,29,32)(H,31,35)/t25-,26-/m1/s1	AGNMDKJKGFYLMR-CLJLJLNGSA-N	256807	US9489013, 78	Beta-secretase 2		 7						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256807&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287511	347916609							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447972	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)C2CC2)S1(=O)=O	InChI=1S/C23H26F2N6O5S2/c1-22(17-11-15(4-7-18(17)25)28-20(32)19-8-3-14(24)12-27-19)23(38(35,36)30(2)21(26)29-22)9-10-31(13-23)37(33,34)16-5-6-16/h3-4,7-8,11-12,16H,5-6,9-10,13H2,1-2H3,(H2,26,29)(H,28,32)/t22-,23-/m1/s1	DSIIMQJQSAWDAZ-DHIUTWEWSA-N	256808	US9489013, 79	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256808&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287657	347916610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447973	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)Cc2cccnc2)S1(=O)=O	InChI=1S/C26H27F2N7O5S2/c1-25(20-12-19(6-7-21(20)28)32-23(36)22-8-5-18(27)14-31-22)26(42(39,40)34(2)24(29)33-25)9-11-35(16-26)41(37,38)15-17-4-3-10-30-13-17/h3-8,10,12-14H,9,11,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26-/m1/s1	NRTWSSMPZHOJQQ-CLJLJLNGSA-N	256809	US9489013, 80	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256809&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287658	347916611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447974	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)c2cn(C)cn2)S1(=O)=O	InChI=1S/C24H26F2N8O5S2/c1-23(17-10-16(5-6-18(17)26)30-21(35)19-7-4-15(25)11-28-19)24(41(38,39)33(3)22(27)31-23)8-9-34(13-24)40(36,37)20-12-32(2)14-29-20/h4-7,10-12,14H,8-9,13H2,1-3H3,(H2,27,31)(H,30,35)/t23-,24-/m1/s1	YFFYIHMPFQKDII-DNQXCXABSA-N	256810	US9489013, 81	Beta-secretase 2		 24						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256810&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287659	347916612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447975	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)CC2CCCO2)S1(=O)=O	InChI=1S/C25H30F2N6O6S2/c1-24(19-12-17(6-7-20(19)27)30-22(34)21-8-5-16(26)13-29-21)25(41(37,38)32(2)23(28)31-24)9-10-33(15-25)40(35,36)14-18-4-3-11-39-18/h5-8,12-13,18H,3-4,9-11,14-15H2,1-2H3,(H2,28,31)(H,30,34)/t18?,24-,25-/m1/s1	VOXHVLOLWMEMEU-XTEKXTAFSA-N	256811	US9489013, 82	Beta-secretase 2		 10						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256811&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287660	347916613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447976	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)c2cn[nH]c2)S1(=O)=O			256812	US9489013, 83	Beta-secretase 2		 11						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256812&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287806	347916614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447977	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@]2(CCN(C2)S(=O)(=O)C2CCCC2)S1(=O)=O	InChI=1S/C25H30F2N6O5S2/c1-24(19-13-17(8-9-20(19)27)30-22(34)21-10-7-16(26)14-29-21)25(40(37,38)32(2)23(28)31-24)11-12-33(15-25)39(35,36)18-5-3-4-6-18/h7-10,13-14,18H,3-6,11-12,15H2,1-2H3,(H2,28,31)(H,30,34)/t24-,25-/m1/s1	WZYBBCDHRDVZEE-JWQCQUIFSA-N	256813	US9489013, 84	Beta-secretase 2		 2						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256813&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287807	347916615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447978	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)C2CCCC2)S1(=O)=O	InChI=1S/C25H30F2N6O5S2/c1-24(19-13-17(8-9-20(19)27)30-22(34)21-10-7-16(26)14-29-21)25(40(37,38)32(2)23(28)31-24)11-12-33(15-25)39(35,36)18-5-3-4-6-18/h7-10,13-14,18H,3-6,11-12,15H2,1-2H3,(H2,28,31)(H,30,34)/t24-,25+/m1/s1	WZYBBCDHRDVZEE-RPBOFIJWSA-N	256814	US9489013, 85	Beta-secretase 2		 37						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256814&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287808	347916616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447979	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)CC2CCCO2)S1(=O)=O	InChI=1S/C25H30F2N6O6S2/c1-24(19-12-17(6-7-20(19)27)30-22(34)21-8-5-16(26)13-29-21)25(41(37,38)32(2)23(28)31-24)9-10-33(15-25)40(35,36)14-18-4-3-11-39-18/h5-8,12-13,18H,3-4,9-11,14-15H2,1-2H3,(H2,28,31)(H,30,34)/t18?,24-,25+/m1/s1	VOXHVLOLWMEMEU-MGAPBXJLSA-N	256815	US9489013, 86	Beta-secretase 2		 20						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256815&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287809	347916617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447980	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)c2cn[nH]c2)S1(=O)=O			256816	US9489013, 87	Beta-secretase 2		 5						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256816&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287810	347916618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447981	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(C)(=O)=O)S1(=O)=O	InChI=1S/C21H24F2N6O5S2/c1-20(15-10-14(5-6-16(15)23)26-18(30)17-7-4-13(22)11-25-17)21(8-9-29(12-21)35(3,31)32)36(33,34)28(2)19(24)27-20/h4-7,10-11H,8-9,12H2,1-3H3,(H2,24,27)(H,26,30)/t20-,21+/m1/s1	MMNYGNJXLCCNNR-RTWAWAEBSA-N	256817	US9489013, 88	Beta-secretase 2		 54						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256817&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287952	347916619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447982	CCS(=O)(=O)N1CC[C@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C22H26F2N6O5S2/c1-4-36(32,33)30-10-9-22(13-30)21(2,28-20(25)29(3)37(22,34)35)16-11-15(6-7-17(16)24)27-19(31)18-8-5-14(23)12-26-18/h5-8,11-12H,4,9-10,13H2,1-3H3,(H2,25,28)(H,27,31)/t21-,22+/m1/s1	YCSGFNKKJYBAEN-YADHBBJMSA-N	256818	US9489013, 89	Beta-secretase 2		 41						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256818&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287953	347916620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447983	CC(C)CS(=O)(=O)N1CC[C@]2(C1)[C@](C)(NC(=N)N(C)S2(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C24H30F2N6O5S2/c1-15(2)13-38(34,35)32-10-9-24(14-32)23(3,30-22(27)31(4)39(24,36)37)18-11-17(6-7-19(18)26)29-21(33)20-8-5-16(25)12-28-20/h5-8,11-12,15H,9-10,13-14H2,1-4H3,(H2,27,30)(H,29,33)/t23-,24+/m1/s1	JKTLLQUTYSVYQN-RPWUZVMVSA-N	256819	US9489013, 90	Beta-secretase 2		 29						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256819	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256819&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287954	347916621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447984	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)c2ccccc2)S1(=O)=O	InChI=1S/C26H26F2N6O5S2/c1-25(20-14-18(9-10-21(20)28)31-23(35)22-11-8-17(27)15-30-22)26(41(38,39)33(2)24(29)32-25)12-13-34(16-26)40(36,37)19-6-4-3-5-7-19/h3-11,14-15H,12-13,16H2,1-2H3,(H2,29,32)(H,31,35)/t25-,26+/m1/s1	AGNMDKJKGFYLMR-FTJBHMTQSA-N	256820	US9489013, 91	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256820	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256820&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287956	347916622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447985	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)C2CC2)S1(=O)=O	InChI=1S/C23H26F2N6O5S2/c1-22(17-11-15(4-7-18(17)25)28-20(32)19-8-3-14(24)12-27-19)23(38(35,36)30(2)21(26)29-22)9-10-31(13-23)37(33,34)16-5-6-16/h3-4,7-8,11-12,16H,5-6,9-10,13H2,1-2H3,(H2,26,29)(H,28,32)/t22-,23+/m1/s1	DSIIMQJQSAWDAZ-PKTZIBPZSA-N	256821	US9489013, 92	Beta-secretase 2		 29						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256821&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285705	347916623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447986	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)Cc2cccnc2)S1(=O)=O	InChI=1S/C26H27F2N7O5S2/c1-25(20-12-19(6-7-21(20)28)32-23(36)22-8-5-18(27)14-31-22)26(42(39,40)34(2)24(29)33-25)9-11-35(16-26)41(37,38)15-17-4-3-10-30-13-17/h3-8,10,12-14H,9,11,15-16H2,1-2H3,(H2,29,33)(H,32,36)/t25-,26+/m1/s1	NRTWSSMPZHOJQQ-FTJBHMTQSA-N	256822	US9489013, 93	Beta-secretase 2		 20						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256822	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256822&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285706	347916624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447987	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)c2cn(C)cn2)S1(=O)=O	InChI=1S/C24H26F2N8O5S2/c1-23(17-10-16(5-6-18(17)26)30-21(35)19-7-4-15(25)11-28-19)24(41(38,39)33(3)22(27)31-23)8-9-34(13-24)40(36,37)20-12-32(2)14-29-20/h4-7,10-12,14H,8-9,13H2,1-3H3,(H2,27,31)(H,30,35)/t23-,24+/m1/s1	YFFYIHMPFQKDII-RPWUZVMVSA-N	256823	US9489013, 94	Beta-secretase 2		 19						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256823	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256823&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674583	347916625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447988	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)[C@@]2(CCN(C2)S(=O)(=O)c2ccc(F)cc2)S1(=O)=O	InChI=1S/C26H25F3N6O5S2/c1-25(20-13-18(6-9-21(20)29)32-23(36)22-10-5-17(28)14-31-22)26(42(39,40)34(2)24(30)33-25)11-12-35(15-26)41(37,38)19-7-3-16(27)4-8-19/h3-10,13-14H,11-12,15H2,1-2H3,(H2,30,33)(H,32,36)/t25-,26+/m1/s1	MMGNGUJAIHDZMD-FTJBHMTQSA-N	256824	US9489013, 95	Beta-secretase 2		 6						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256824	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256824&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122674581	347916626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447989	COCC(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(Cc2ccccc2)S(=O)(=O)[C@@]11CCN(Cc2ccccc2)C1	InChI=1S/C30H34FN5O4S/c1-29(25-17-24(13-14-26(25)31)33-27(37)20-40-2)30(15-16-35(21-30)18-22-9-5-3-6-10-22)41(38,39)36(28(32)34-29)19-23-11-7-4-8-12-23/h3-14,17H,15-16,18-21H2,1-2H3,(H2,32,34)(H,33,37)/t29-,30-/m1/s1	NPJCSXXBLYXRQE-LOYHVIPDSA-N	256825	US9489013, 96	Beta-secretase 2		 25						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256825	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256825&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			131709621	347916627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
447990	COCC(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)[C@@]11CCNC1	InChI=1S/C17H24FN5O4S/c1-16(12-8-11(4-5-13(12)18)21-14(24)9-27-3)17(6-7-20-10-17)28(25,26)23(2)15(19)22-16/h4-5,8,20H,6-7,9-10H2,1-3H3,(H2,19,22)(H,21,24)/t16-,17-/m1/s1	QKQYMYUQLGUHHI-IAGOWNOFSA-N	256826	US9489013, 97	Beta-secretase 2		 782						5	30.00 C	US Patent		10.7270/Q2Q81C18		aid1803611	US9489013	Cumming, JN; Kaelin, Jr., DE; Scott, JD; Stamford, AW; Iserloh, U	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=256826	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=256826&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285709	347916628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525125	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(Cl)cnc23)ccc1F	InChI=1S/C19H18ClFN6O2S/c1-19(10-30(28,29)27(2)18(22)26-19)14-8-13(3-4-15(14)21)25-17-16-11(5-6-23-17)7-12(20)9-24-16/h3-9H,10H2,1-2H3,(H2,22,26)(H,23,25)/t19-/m0/s1	GAZOPRYFZALSHV-IBGZPJMESA-N	276786	3-chloro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-1,7-naphthyridin-8-amine::US10071998, Example 1	Beta-secretase 2		 0.220						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276786&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435125	378158443							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525127	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(Br)cnc23)ccc1F	InChI=1S/C19H18BrFN6O2S/c1-19(10-30(28,29)27(2)18(22)26-19)14-8-13(3-4-15(14)21)25-17-16-11(5-6-23-17)7-12(20)9-24-16/h3-9H,10H2,1-2H3,(H2,22,26)(H,23,25)/t19-/m0/s1	SOEUZVDUBKCDGB-IBGZPJMESA-N	276787	3-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-1,7-naphthyridin-8-amine::US10071998, Example 2	Beta-secretase 2		 0.380						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276787&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435133	378158444							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525129	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2ncnc3cc(Br)cnc23)ccc1F	InChI=1S/C18H17BrFN7O2S/c1-18(8-30(28,29)27(2)17(21)26-18)12-6-11(3-4-13(12)20)25-16-15-14(23-9-24-16)5-10(19)7-22-15/h3-7,9H,8H2,1-2H3,(H2,21,26)(H,23,24,25)/t18-/m0/s1	OQRKAIXNIOZZEN-SFHVURJKSA-N	276788	7-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}pyrido[3,2-d]pyrimidin-4-amine::US10071998, Example 3	Beta-secretase 2		 0.810						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276788&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435137	378158445							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525131	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2c1	InChI=1S/C20H21FN6O3S/c1-20(11-31(28,29)27(2)19(22)26-20)15-9-13(4-5-16(15)21)25-18-17-12(6-7-23-18)8-14(30-3)10-24-17/h4-10H,11H2,1-3H3,(H2,22,26)(H,23,25)/t20-/m0/s1	QBRFLMCPVOBSGI-FQEVSTJZSA-N	276789	N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-3-methoxy-1,7-naphthyridin-8-amine::US10071998, Example 4	Beta-secretase 2		 5.80						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276789&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435134	378158446							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50093307	CN1C(N)=N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F	InChI=1S/C18H17F3N6O4S/c1-27-17(22)26-18(8-31-7-14(18)32(27,29)30)10-4-9(2-3-11(10)19)25-16(28)13-6-23-12(5-24-13)15(20)21/h2-6,14-15H,7-8H2,1H3,(H2,22,26)(H,25,28)/t14-,18-/m1/s1	IQUBPELHSBAKON-RDTXWAMCSA-N	50012646	CHEMBL3261056	Beta-secretase 2		 17								ChEMBL	10.1016/j.bmcl.2014.03.025	10.7270/Q2H41T0Z	24704031			Oehlrich, D; Prokopcova, H; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012646	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012646&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71468021	103924899		CHEMBL3261056				ZINC29409967	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50093309	Cc1cc(on1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H17F2N3O2S/c1-9-4-15(24-22-9)14-5-10-7-25-16(20)21-17(10,8-23-14)12-3-2-11(18)6-13(12)19/h2-4,6,10,14H,5,7-8H2,1H3,(H2,20,21)/t10?,14-,17+/m1/s1	APXCHRRPLFZFMP-WETSXSAHSA-N	50012648	CHEMBL3261057	Beta-secretase 2			 4550							ChEMBL	10.1016/j.bmcl.2014.03.025	10.7270/Q2H41T0Z	24704031			Oehlrich, D; Prokopcova, H; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012648	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012648&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90656187	103924901		CHEMBL3261057				ZINC29464389	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50157478	COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F	InChI=1S/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/m1/s1	JIBQVJZSWQNHLX-HSZRJFAPSA-N	50303727	(4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL584695	Beta-secretase 2			 1640							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303727&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488105	104158088		CHEMBL584695				ZINC43152619	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50157479	COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C22H29N3O2/c1-13-6-17(4-5-18(13)27-3)22(19(26)25(2)20(23)24-22)21-10-14-7-15(11-21)9-16(8-14)12-21/h4-6,14-16H,7-12H2,1-3H3,(H2,23,24)/t14?,15?,16?,21?,22-/m0/s1	HZIOSWLCMNAEBB-RCRNZYILSA-N	50303734	(S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL571320	Beta-secretase 2			 4020							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303734&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	X17	3INE	45488104	104158095		CHEMBL571320				ZINC45283585	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50157505	COc1ccc(cc1)[C@@]1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C21H27N3O2/c1-24-18(25)21(23-19(24)22,16-3-5-17(26-2)6-4-16)20-10-13-7-14(11-20)9-15(8-13)12-20/h3-6,13-15H,7-12H2,1-2H3,(H2,22,23)/t13?,14?,15?,20?,21-/m0/s1	BGCGXOOJJMGOQV-CPGUEHHYSA-N	50303748	(S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL585128	Beta-secretase 2			 230							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303748&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488098	104158109		CHEMBL585128				ZINC34948148	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50157518	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)(F)F)cc1)c1ccc(F)c(c1)-c1cncnc1	InChI=1S/C21H15F4N5O2/c1-30-18(31)20(29-19(30)26,13-2-5-15(6-3-13)32-21(23,24)25)14-4-7-17(22)16(8-14)12-9-27-11-28-10-12/h2-11H,1H3,(H2,26,29)/t20-/m1/s1	RNJTYVPMRSKRKE-HXUWFJFHSA-N	50303731	(5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one::(R)-2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL568115	Beta-secretase 2			 7540							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	569	3INH	11539562	104158092		CHEMBL568115				ZINC34631070	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50176681	CCn1cc(cn1)[C@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C20H19FN6O/c1-3-27-12-15(11-24-27)20(18(28)26(2)19(22)25-20)14-7-4-6-13(10-14)16-8-5-9-23-17(16)21/h4-12H,3H2,1-2H3,(H2,22,25)/t20-/m1/s1	IKJXVRPWMOVIMY-HXUWFJFHSA-N	50352850	CHEMBL1824335	Beta-secretase 2			 450							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352850	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352850&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56668818	136359536		CHEMBL1824335				ZINC72182337	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50224304	C[C@@H](C(=O)NCc1ccc(CN)cc1)c1ccc(c(F)c1)-c1ccccc1	InChI=1S/C23H23FN2O/c1-16(23(27)26-15-18-9-7-17(14-25)8-10-18)20-11-12-21(22(24)13-20)19-5-3-2-4-6-19/h2-13,16H,14-15,25H2,1H3,(H,26,27)/t16-/m1/s1	FHYZRKQSKXWLMZ-MRXNPFEDSA-N	50427055	CHEMBL2322536	Beta-secretase 2			 193800							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427055&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71584647	164155930		CHEMBL2322536				ZINC95580786	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50213980	CS(=O)(=O)N(c1ccncc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C31H31F3N4O4S/c1-43(41,42)38(26-13-15-35-16-14-26)27-12-6-10-24(19-27)30(40)37-28(18-22-7-3-2-4-8-22)29(39)21-36-20-23-9-5-11-25(17-23)31(32,33)34/h2-17,19,28-29,36,39H,18,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	SOGVSPVLCXEDPN-URLMMPGGSA-N	50322907	CHEMBL1210353::CHEMBL1210357::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-4-yl)methylsulfonamido)benzamide hydrochloride	Beta-secretase 2			 580							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322907&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10371570	117644228		CHEMBL1210357CHEMBL1210353				ZINC58468484	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50213993	CS(=O)(=O)N(c1cccnc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C31H31F3N4O4S/c1-43(41,42)38(27-14-7-15-35-20-27)26-13-6-11-24(18-26)30(40)37-28(17-22-8-3-2-4-9-22)29(39)21-36-19-23-10-5-12-25(16-23)31(32,33)34/h2-16,18,20,28-29,36,39H,17,19,21H2,1H3,(H,37,40)/t28-,29+/m0/s1	XGQFYIAWNPUACI-URLMMPGGSA-N	50322906	CHEMBL1210358::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-3-yl)methylsulfonamido)benzamide	Beta-secretase 2			 2290							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322906&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10483887	117644227		CHEMBL1210358				ZINC58598836	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50213997	CS(=O)(=O)N(c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)c1ccccn1	InChI=1S/C31H31F3N4O4S/c1-43(41,42)38(29-15-5-6-16-36-29)26-14-8-12-24(19-26)30(40)37-27(18-22-9-3-2-4-10-22)28(39)21-35-20-23-11-7-13-25(17-23)31(32,33)34/h2-17,19,27-28,35,39H,18,20-21H2,1H3,(H,37,40)/t27-,28+/m0/s1	NLBLQQZAHZCPKB-WUFINQPMSA-N	50322905	CHEMBL1210351::CHEMBL1788375::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-2-yl)methylsulfonamido)benzamide::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-2-yl)methylsulfonamido)benzamide hydrobromide	Beta-secretase 2			 28180							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322905&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			9986236	117644226		CHEMBL1210351CHEMBL1788375				ZINC58594138	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50218507	CC#Cc1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CC(=O)N(C)C(N)=N1	InChI=1S/C18H17ClN4OS/c1-4-5-11-6-12(10-21-9-11)14-7-13(19)16(25-14)18(2)8-15(24)23(3)17(20)22-18/h6-7,9-10H,8H2,1-3H3,(H2,20,22)/t18-/m0/s1	IJYPXSRDUPWKPB-SFHVURJKSA-N	50392835	CHEMBL2151181	Beta-secretase 2		<1								ChEMBL	10.1021/ml3001165	10.7270/Q23779SN	23412139			Stamford, AW; Scott, JD; Li, SW; Babu, S; Tadesse, D; Hunter, R; Wu, Y; Misiaszek, J; Cumming, JN; Gilbert, EJ; Huang, C; McKittrick, BA; Hong, L; Guo, T; Zhu, Z; Strickland, C; Orth, P; Voigt, JH; Kennedy, ME; Chen, X; Kuvelkar, R; Hodgson, R; Hyde, LA; Cox, K; Favreau, L; Parker, EM; Greenlee, WJ	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392835	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392835&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			66575082	163341859		CHEMBL2151181				ZINC95571882	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50246267	CC(C)(C)COc1ccc2Oc3ccc(cc3[C@@]3(COC(N)=N3)c2c1)-c1cncnc1	InChI=1S/C24H24N4O3/c1-23(2,3)12-29-17-5-7-21-19(9-17)24(13-30-22(25)28-24)18-8-15(4-6-20(18)31-21)16-10-26-14-27-11-16/h4-11,14H,12-13H2,1-3H3,(H2,25,28)/t24-/m0/s1	CHZHWZAKWGFQNL-DEOSSOPVSA-N	50031612	CHEMBL3354688	Beta-secretase 2			 15							ChEMBL	10.1021/jm5012676	10.7270/Q20G3MRW	25363711			Dineen, TA; Chen, K; Cheng, AC; Derakhchan, K; Epstein, O; Esmay, J; Hickman, D; Kreiman, CE; Marx, IE; Wahl, RC; Wen, PH; Weiss, MM; Whittington, DA; Wood, S; Fremeau, RT; White, RD; Patel, VF	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031612&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	3LN	4RCE	45256109	313066105		CHEMBL3354688					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50246268	CC1(COC1)C#Cc1cnc2Oc3ccc(cc3[C@@]3(COC(N)=N3)c2c1)-c1cccnc1F	InChI=1S/C25H19FN4O3/c1-24(12-31-13-24)7-6-15-9-19-22(29-11-15)33-20-5-4-16(17-3-2-8-28-21(17)26)10-18(20)25(19)14-32-23(27)30-25/h2-5,8-11H,12-14H2,1H3,(H2,27,30)/t25-/m0/s1	GKKFBOARESVMBW-VWLOTQADSA-N	50031613	CHEMBL3359763	Beta-secretase 2			 5.0							ChEMBL	10.1021/jm5012676	10.7270/Q20G3MRW	25363711			Dineen, TA; Chen, K; Cheng, AC; Derakhchan, K; Epstein, O; Esmay, J; Hickman, D; Kreiman, CE; Marx, IE; Wahl, RC; Wen, PH; Weiss, MM; Whittington, DA; Wood, S; Fremeau, RT; White, RD; Patel, VF	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031613&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	3LL	4RCD	45254510	313066106		CHEMBL3359763					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50262689	CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CNC(=O)OC(C)(C)C)NC(=O)[C@@H](C)Cc1nc(C)cs1)C(C)C	InChI=1S/C35H62N6O7S/c1-19(2)13-25(27(42)14-22(7)31(44)41-29(21(5)6)33(46)36-16-20(3)4)39-32(45)26(17-37-34(47)48-35(10,11)12)40-30(43)23(8)15-28-38-24(9)18-49-28/h18-23,25-27,29,42H,13-17H2,1-12H3,(H,36,46)(H,37,47)(H,39,45)(H,40,43)(H,41,44)/t22-,23+,25+,26+,27+,29+/m1/s1	GUFJTLQVFGVMAQ-WGRPDLKCSA-N	50042296	CHEMBL3352906	Beta-secretase 2		 71								ChEMBL	10.1016/j.bmcl.2014.11.087	10.7270/Q2N58P0J	25537272			Ghosh, AK; Brindisi, M; Yen, YC; Xu, X; Huang, X; Devasamudram, T; Bilcer, G; Lei, H; Koelsch, G; Mesecar, AD; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042296	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042296&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90693645	103973902		CHEMBL3352906				ZINC13775701	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50284126	CCOC[C@@H](CC(C)C)NC(=O)[C@@H]1CNC[C@@H]([C@@H]1O)C(=O)N(C1CC1)c1ccc(cn1)C(C)C	InChI=1S/C26H42N4O4/c1-6-34-15-19(11-16(2)3)29-25(32)21-13-27-14-22(24(21)31)26(33)30(20-8-9-20)23-10-7-18(12-28-23)17(4)5/h7,10,12,16-17,19-22,24,27,31H,6,8-9,11,13-15H2,1-5H3,(H,29,32)/t19-,21-,22+,24-/m1/s1	YOVGCKBDPOHLAV-CNIHBODFSA-N	98678	US8497286, 154	Beta-secretase 2			>30000							ChEMBL	10.1021/ml500137b	10.7270/Q2WD4279	25050166			Ehara, T; Irie, O; Kosaka, T; Kanazawa, T; Breitenstein, W; Grosche, P; Ostermann, N; Suzuki, M; Kawakami, S; Konishi, K; Hitomi, Y; Toyao, A; Gunji, H; Cumin, F; Schiering, N; Wagner, T; Rigel, DF; Webb, RL; Maibaum, J; Yokokawa, F	Novartis Institutes for BioMedical Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=98678	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=98678&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	2Y9	4Q1N	25143506	164039922						ZINC96168509	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50301591	CC(C)[C@]1(C)CC(=O)N(Cc2cc(F)cc(c2)C(=O)N[C@@H](C)c2ccccc2)C(=N)N1	InChI=1S/C24H29FN4O2/c1-15(2)24(4)13-21(30)29(23(26)28-24)14-17-10-19(12-20(25)11-17)22(31)27-16(3)18-8-6-5-7-9-18/h5-12,15-16H,13-14H2,1-4H3,(H2,26,28)(H,27,31)/t16-,24-/m0/s1	PGSGWIDQXZCHJL-FYSMJZIKSA-N	50065428	CHEMBL3401350	Beta-secretase 2		 480								ChEMBL	10.1016/j.bmcl.2015.02.003	10.7270/Q2X63PMJ	25728416			McKittrick, BA; Caldwell, JP; Bara, T; Boykow, G; Chintala, M; Clader, J; Czarniecki, M; Courneya, B; Duffy, R; Fleming, L; Giessert, R; Greenlee, WJ; Heap, C; Hong, L; Huang, Y; Iserloh, U; Josien, H; Khan, T; Korfmacher, W; Liang, X; Mazzola, R; Mitra, S; Moore, K; Orth, P; Rajagopalan, M; Roy, S; Sakwa, S; Strickland, C; Vaccaro, H; Voigt, J; Wang, H; Wong, J; Zhang, R; Zych, A	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50065428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50065428&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			60149247	313071387		CHEMBL3401350					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50302835	COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]1CNC[C@H]1NCc1ccc2ccccc2c1)C(C)C	InChI=1S/C31H41N3O4/c1-22(2)34(31(35)26-12-13-29(37-4)30(17-26)38-15-7-14-36-3)21-27-19-32-20-28(27)33-18-23-10-11-24-8-5-6-9-25(24)16-23/h5-6,8-13,16-17,22,27-28,32-33H,7,14-15,18-21H2,1-4H3/t27-,28+/m0/s1	XZJFCCNTHXFRPO-WUFINQPMSA-N	50066260	CHEMBL3400435	Beta-secretase 2			>10000							ChEMBL	10.1016/j.bmcl.2015.02.039	10.7270/Q2Z039TX	25782742			Lorthiois, E; Cumin, F; Ehrhardt, C; Kosaka, T; Sellner, H; Ostermann, N; Francotte, E; Wagner, T; Maibaum, J	Novartis Pharma AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066260&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68448803	103960914		CHEMBL3400435				ZINC36273077	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50301957	COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]1CNC[C@H]1OC(=O)NCc1ccccc1)C(C)C	InChI=1S/C28H39N3O6/c1-20(2)31(27(32)22-11-12-24(35-4)25(15-22)36-14-8-13-34-3)19-23-17-29-18-26(23)37-28(33)30-16-21-9-6-5-7-10-21/h5-7,9-12,15,20,23,26,29H,8,13-14,16-19H2,1-4H3,(H,30,33)/t23-,26+/m0/s1	WGHJKYWWSVIRLL-JYFHCDHNSA-N	50065660	CHEMBL3403995	Beta-secretase 2			>30000							ChEMBL	10.1016/j.bmcl.2015.02.040	10.7270/Q2RF5WPJ	25754490			Sellner, H; Cottens, S; Cumin, F; Ehrhardt, C; Kosaka, T; Lorthiois, E; Ostermann, N; Webb, RL; Rigel, DF; Wagner, T; Maibaum, J	Novartis Pharma AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50065660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50065660&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	3ZN	4RZ1	59271992	313071486		CHEMBL3403995					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50349899	NC1=NC2CCC(CC2CS1)NC(=O)c1ccccc1	InChI=1S/C15H19N3OS/c16-15-18-13-7-6-12(8-11(13)9-20-15)17-14(19)10-4-2-1-3-5-10/h1-5,11-13H,6-9H2,(H2,16,18)(H,17,19)	WGWSESJJAYIMCO-UHFFFAOYSA-N	50092472	CHEMBL3586138	Beta-secretase 2			 11100							ChEMBL	10.1016/j.bmc.2015.04.062	10.7270/Q2J67JNF	26001341			Winneroski, LL; Schiffler, MA; Erickson, JA; May, PC; Monk, SA; Timm, DE; Audia, JE; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hudziak, KJ; Klimkowski, VJ; Garcia Losada, P; Mathes, BM; Stout, SL; Watson, BM; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092472&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180117	318473241		CHEMBL3586138					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50349900	NC1=NC2CCC(CC2CS1)NC(=O)c1ccc(F)cn1	InChI=1S/C14H17FN4OS/c15-9-1-3-12(17-6-9)13(20)18-10-2-4-11-8(5-10)7-21-14(16)19-11/h1,3,6,8,10-11H,2,4-5,7H2,(H2,16,19)(H,18,20)	PDBMBHJMZZEVFL-UHFFFAOYSA-N	50092467	CHEMBL3586137	Beta-secretase 2			 26300							ChEMBL	10.1016/j.bmc.2015.04.062	10.7270/Q2J67JNF	26001341			Winneroski, LL; Schiffler, MA; Erickson, JA; May, PC; Monk, SA; Timm, DE; Audia, JE; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hudziak, KJ; Klimkowski, VJ; Garcia Losada, P; Mathes, BM; Stout, SL; Watson, BM; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092467	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092467&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180115	318473236		CHEMBL3586137					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50349901	NC1=NC2CCC(CC2CS1)OC(=O)c1cccc(Cl)c1	InChI=1S/C15H17ClN2O2S/c16-11-3-1-2-9(6-11)14(19)20-12-4-5-13-10(7-12)8-21-15(17)18-13/h1-3,6,10,12-13H,4-5,7-8H2,(H2,17,18)	OADYDVBNNUAOEU-UHFFFAOYSA-N	50092468	CHEMBL3586133	Beta-secretase 2			 584							ChEMBL	10.1016/j.bmc.2015.04.062	10.7270/Q2J67JNF	26001341			Winneroski, LL; Schiffler, MA; Erickson, JA; May, PC; Monk, SA; Timm, DE; Audia, JE; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hudziak, KJ; Klimkowski, VJ; Garcia Losada, P; Mathes, BM; Stout, SL; Watson, BM; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092468	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092468&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180113	318473237		CHEMBL3586133					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50349902	NC1=NC23COCC2(CS1)CC(CC3)NC(=O)c1cccc(Cl)c1	InChI=1S/C17H20ClN3O2S/c18-12-3-1-2-11(6-12)14(22)20-13-4-5-17-9-23-8-16(17,7-13)10-24-15(19)21-17/h1-3,6,13H,4-5,7-10H2,(H2,19,21)(H,20,22)	XDMHBNONUZHFDP-UHFFFAOYSA-N	50092469	CHEMBL3586132	Beta-secretase 2			 22700							ChEMBL	10.1016/j.bmc.2015.04.062	10.7270/Q2J67JNF	26001341			Winneroski, LL; Schiffler, MA; Erickson, JA; May, PC; Monk, SA; Timm, DE; Audia, JE; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hudziak, KJ; Klimkowski, VJ; Garcia Losada, P; Mathes, BM; Stout, SL; Watson, BM; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092469	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092469&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180111	318473238		CHEMBL3586132					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50349903	NC1=N[C@]23CC[C@@H](C[C@@H]2[C@@H](COC3)S1)NC(=O)c1cccc(Cl)c1	InChI=1S/C17H20ClN3O2S/c18-11-3-1-2-10(6-11)15(22)20-12-4-5-17-9-23-8-14(13(17)7-12)24-16(19)21-17/h1-3,6,12-14H,4-5,7-9H2,(H2,19,21)(H,20,22)/t12-,13+,14+,17-/m0/s1	SLYXQQNGVHPIRQ-CFAJVAMVSA-N	50092470	CHEMBL3586131	Beta-secretase 2			 1340							ChEMBL	10.1016/j.bmc.2015.04.062	10.7270/Q2J67JNF	26001341			Winneroski, LL; Schiffler, MA; Erickson, JA; May, PC; Monk, SA; Timm, DE; Audia, JE; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hudziak, KJ; Klimkowski, VJ; Garcia Losada, P; Mathes, BM; Stout, SL; Watson, BM; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092470	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092470&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71714118	318473239		CHEMBL3586131					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50349904	NC1=NC2CCC(CC2CS1)NC(=O)c1cccc(Cl)c1	InChI=1S/C15H18ClN3OS/c16-11-3-1-2-9(6-11)14(20)18-12-4-5-13-10(7-12)8-21-15(17)19-13/h1-3,6,10,12-13H,4-5,7-8H2,(H2,17,19)(H,18,20)	TUSBLKXHGGIFCU-UHFFFAOYSA-N	50092471	CHEMBL3586130	Beta-secretase 2			 497							ChEMBL	10.1016/j.bmc.2015.04.062	10.7270/Q2J67JNF	26001341			Winneroski, LL; Schiffler, MA; Erickson, JA; May, PC; Monk, SA; Timm, DE; Audia, JE; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hudziak, KJ; Klimkowski, VJ; Garcia Losada, P; Mathes, BM; Stout, SL; Watson, BM; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092471	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092471&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180108	318473240		CHEMBL3586130					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50354765	CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O	InChI=1S/C44H69N7O15/c1-22(2)17-29(47-42(63)31(21-36(57)58)49-41(62)30(18-23(3)4)48-39(60)27(45)13-15-34(53)54)33(52)19-25(7)38(59)51-37(24(5)6)43(64)46-28(14-16-35(55)56)40(61)50-32(44(65)66)20-26-11-9-8-10-12-26/h8-12,22-25,27-33,37,52H,13-21,45H2,1-7H3,(H,46,64)(H,47,63)(H,48,60)(H,49,62)(H,50,61)(H,51,59)(H,53,54)(H,55,56)(H,57,58)(H,65,66)/t25-,27+,28+,29+,30+,31+,32+,33+,37+/m1/s1	CFIWWTUUSMMDDA-IQRKPKHNSA-N	50210579	(2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benzyl-5-(2-carboxyethyl)-17-(carboxymethyl)-13-hydroxy-14,20-diisobutyl-8-isopropyl-11-methyl-4,7,10,16,19,22-hexaoxo-3,6,9,15,18,21-hexaazahexacosane-1,26-dioic acid::CHEMBL390456::OM00-3	Beta-secretase 2		 3.0								ChEMBL	10.1021/acs.jmedchem.5b00658	10.7270/Q2HX1FDQ	26061085			Vila-Real, H; Coelho, H; Rocha, J; Fernandes, A; Ventura, MR; Maycock, CD; Iranzo, O; Simplício, AL	Instituto de Biologia Experimental e Tecnol&#163;gica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50210579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50210579&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			447068	104087082		CHEMBL390456					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50354766	CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(N)=O	InChI=1S/C60H89N11O19/c1-30(2)23-39(65-59(89)44(29-49(79)80)69-57(87)41(24-31(3)4)67-54(84)37(61)19-21-46(73)74)45(72)25-33(7)52(82)71-50(32(5)6)60(90)70-43(27-36-17-13-10-14-18-36)58(88)68-42(26-35-15-11-9-12-16-35)56(86)63-34(8)53(83)64-38(20-22-47(75)76)55(85)66-40(51(62)81)28-48(77)78/h9-18,30-34,37-45,50,72H,19-29,61H2,1-8H3,(H2,62,81)(H,63,86)(H,64,83)(H,65,89)(H,66,85)(H,67,84)(H,68,88)(H,69,87)(H,70,90)(H,71,82)(H,73,74)(H,75,76)(H,77,78)(H,79,80)/t33-,34+,37+,38+,39+,40+,41+,42+,43+,44+,45+,50+/m1/s1	WOZYNBSGWPZEBE-LAVLDKPHSA-N	50094976	CHEMBL3588999	Beta-secretase 2		 7.3								ChEMBL	10.1021/acs.jmedchem.5b00658	10.7270/Q2HX1FDQ	26061085			Vila-Real, H; Coelho, H; Rocha, J; Fernandes, A; Ventura, MR; Maycock, CD; Iranzo, O; Simplício, AL	Instituto de Biologia Experimental e Tecnol&#163;gica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094976&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180628	318473560		CHEMBL3588999					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50354767	CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(N)=O	InChI=1S/C60H89N11O20/c1-29(2)22-39(65-59(90)44(28-49(80)81)69-57(88)41(23-30(3)4)67-54(85)37(61)18-20-46(74)75)45(73)24-32(7)52(83)71-50(31(5)6)60(91)70-43(25-34-12-10-9-11-13-34)58(89)68-42(26-35-14-16-36(72)17-15-35)56(87)63-33(8)53(84)64-38(19-21-47(76)77)55(86)66-40(51(62)82)27-48(78)79/h9-17,29-33,37-45,50,72-73H,18-28,61H2,1-8H3,(H2,62,82)(H,63,87)(H,64,84)(H,65,90)(H,66,86)(H,67,85)(H,68,89)(H,69,88)(H,70,91)(H,71,83)(H,74,75)(H,76,77)(H,78,79)(H,80,81)/t32-,33+,37+,38+,39+,40+,41+,42+,43+,44+,45+,50+/m1/s1	QYPZKGAQRCJRQN-WDYKYHLQSA-N	50094977	CHEMBL3589000	Beta-secretase 2		 14								ChEMBL	10.1021/acs.jmedchem.5b00658	10.7270/Q2HX1FDQ	26061085			Vila-Real, H; Coelho, H; Rocha, J; Fernandes, A; Ventura, MR; Maycock, CD; Iranzo, O; Simplício, AL	Instituto de Biologia Experimental e Tecnol&#163;gica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094977&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180629	318473561		CHEMBL3589000					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50354768	CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(C)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(N)=O	InChI=1S/C62H91N11O21/c1-30(2)23-41(67-61(93)46(29-51(83)84)71-59(91)43(24-31(3)4)69-56(88)39(65-35(9)74)19-21-48(77)78)47(76)25-33(7)54(86)73-52(32(5)6)62(94)72-45(26-36-13-11-10-12-14-36)60(92)70-44(27-37-15-17-38(75)18-16-37)58(90)64-34(8)55(87)66-40(20-22-49(79)80)57(89)68-42(53(63)85)28-50(81)82/h10-18,30-34,39-47,52,75-76H,19-29H2,1-9H3,(H2,63,85)(H,64,90)(H,65,74)(H,66,87)(H,67,93)(H,68,89)(H,69,88)(H,70,92)(H,71,91)(H,72,94)(H,73,86)(H,77,78)(H,79,80)(H,81,82)(H,83,84)/t33-,34+,39+,40+,41+,42+,43+,44+,45+,46+,47+,52+/m1/s1	NEPHUDYRMYLGFC-DBXJSOEISA-N	50094978	CHEMBL3589001	Beta-secretase 2		 18								ChEMBL	10.1021/acs.jmedchem.5b00658	10.7270/Q2HX1FDQ	26061085			Vila-Real, H; Coelho, H; Rocha, J; Fernandes, A; Ventura, MR; Maycock, CD; Iranzo, O; Simplício, AL	Instituto de Biologia Experimental e Tecnol&#163;gica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094978&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180630	318473562		CHEMBL3589001					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50354769	CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O	InChI=1S/C60H88N10O21/c1-29(2)22-39(64-58(88)43(27-48(77)78)67-56(86)40(23-30(3)4)65-53(83)37(61)18-20-46(73)74)45(72)24-32(7)51(81)70-50(31(5)6)59(89)68-42(25-34-12-10-9-11-13-34)57(87)66-41(26-35-14-16-36(71)17-15-35)55(85)62-33(8)52(82)63-38(19-21-47(75)76)54(84)69-44(60(90)91)28-49(79)80/h9-17,29-33,37-45,50,71-72H,18-28,61H2,1-8H3,(H,62,85)(H,63,82)(H,64,88)(H,65,83)(H,66,87)(H,67,86)(H,68,89)(H,69,84)(H,70,81)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,90,91)/t32-,33+,37+,38+,39+,40+,41+,42+,43+,44+,45+,50+/m1/s1	UOESAZIFUQNOCK-WDYKYHLQSA-N	50094979	CHEMBL3589002	Beta-secretase 2		 13								ChEMBL	10.1021/acs.jmedchem.5b00658	10.7270/Q2HX1FDQ	26061085			Vila-Real, H; Coelho, H; Rocha, J; Fernandes, A; Ventura, MR; Maycock, CD; Iranzo, O; Simplício, AL	Instituto de Biologia Experimental e Tecnol&#163;gica	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094979&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122180631	318473563		CHEMBL3589002			C02715		1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50382619	CC(C)C[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)P(O)(=O)CC(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O	InChI=1S/C43H68N7O16P/c1-22(2)17-29(46-38(58)27(44)13-15-33(51)52)40(60)47-30(20-35(55)56)41(61)49-32(18-23(3)4)67(65,66)21-25(7)37(57)50-36(24(5)6)42(62)45-28(14-16-34(53)54)39(59)48-31(43(63)64)19-26-11-9-8-10-12-26/h8-12,22-25,27-32,36H,13-21,44H2,1-7H3,(H,45,62)(H,46,58)(H,47,60)(H,48,59)(H,49,61)(H,50,57)(H,51,52)(H,53,54)(H,55,56)(H,63,64)(H,65,66)/t25?,27-,28-,29-,30-,31-,32+,36-/m0/s1	VTXVJJPVSDWYLH-ZHYMVPAZSA-N	50210578	CHEMBL242315::H-(S)Glu-(S)Leu-Asp-(R)Leupsi [POOH-CH2]-Ala-(S)Val-(S)Glu-(S)Phe-OH	Beta-secretase 2			 12							ChEMBL	10.1016/j.bmc.2007.03.072	10.7270/Q24M9478	17433698			Manzenrieder, F; Frank, AO; Huber, T; Dorner-Ciossek, C; Kessler, H	Technische Universit&#228;t M&#252;nchen	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50210578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50210578&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16730753	104087081		CHEMBL242315					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50385426	CCCN(c1cc2COC[C@](C)(N)Cc3cccc(CC[C@@H](NC(=O)c(c2)c1)c1ccccc1)c3)S(C)(=O)=O	InChI=1S/C31H39N3O4S/c1-4-15-34(39(3,36)37)28-18-25-17-27(19-28)30(35)33-29(26-11-6-5-7-12-26)14-13-23-9-8-10-24(16-23)20-31(2,32)22-38-21-25/h5-12,16-19,29H,4,13-15,20-22,32H2,1-3H3,(H,33,35)/t29-,31-/m1/s1	PHHMGOKZHVGWDE-BVRKHOPBSA-N	50212178	CHEMBL248699::N-((5R,14R)-5-amino-5-methyl-16-oxo-14-phenyl-3-oxa-15-aza-tricyclo[15.3.1.1*7,11*]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl)-N-propyl-methanesulfonamide	Beta-secretase 2			 1600							ChEMBL	10.1016/j.bmcl.2007.04.072	10.7270/Q2Q81CS4	17482814			Lindsley, SR; Moore, KP; Rajapakse, HA; Selnick, HG; Young, MB; Zhu, H; Munshi, S; Kuo, L; McGaughey, GB; Colussi, D; Crouthamel, MC; Lai, MT; Pietrak, B; Price, EA; Sankaranarayanan, S; Simon, AJ; Seabrook, GR; Hazuda, DJ; Pudvah, NT; Hochman, JH; Graham, SL; Vacca, JP; Nantermet, PG	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212178&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44441701	104088192		CHEMBL248699				ZINC28949950	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50385428	CCCN(c1cc2COC(=O)[C@](C)(N)Cc3cccc(CC[C@@H](NC(=O)c(c2)c1)c1ccccc1)c3)S(C)(=O)=O	InChI=1S/C31H37N3O5S/c1-4-15-34(40(3,37)38)27-18-24-17-26(19-27)29(35)33-28(25-11-6-5-7-12-25)14-13-22-9-8-10-23(16-22)20-31(2,32)30(36)39-21-24/h5-12,16-19,28H,4,13-15,20-21,32H2,1-3H3,(H,33,35)/t28-,31-/m1/s1	LLXSJJHSWWXYCR-GRKNLSHJSA-N	50212180	CHEMBL400530::N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-aza-tricyclo[15.3.1.1*7,11*]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl)-N-propyl-methanesulfonamide	Beta-secretase 2			 54000							ChEMBL	10.1016/j.bmcl.2007.04.072	10.7270/Q2Q81CS4	17482814			Lindsley, SR; Moore, KP; Rajapakse, HA; Selnick, HG; Young, MB; Zhu, H; Munshi, S; Kuo, L; McGaughey, GB; Colussi, D; Crouthamel, MC; Lai, MT; Pietrak, B; Price, EA; Sankaranarayanan, S; Simon, AJ; Seabrook, GR; Hazuda, DJ; Pudvah, NT; Hochman, JH; Graham, SL; Vacca, JP; Nantermet, PG	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212180&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44441703	104088194		CHEMBL400530				ZINC28949955	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50385458	C[C@@]1(N)Cc2cccc(CC[C@@H](NC(=O)c3cc(COC1=O)cc(c3)-c1ccccc1C#N)c1ccccc1)c2	InChI=1S/C34H31N3O3/c1-34(36)20-24-9-7-8-23(16-24)14-15-31(26-10-3-2-4-11-26)37-32(38)29-18-25(22-40-33(34)39)17-28(19-29)30-13-6-5-12-27(30)21-35/h2-13,16-19,31H,14-15,20,22,36H2,1H3,(H,37,38)/t31-,34-/m1/s1	LTHZWJXJHAGGMX-QIKUIUABSA-N	50212189	2-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-aza-tricyclo[15.3.1.1*7,11*]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl)-benzonitrile::CHEMBL401180	Beta-secretase 2			 41000							ChEMBL	10.1016/j.bmcl.2007.04.072	10.7270/Q2Q81CS4	17482814			Lindsley, SR; Moore, KP; Rajapakse, HA; Selnick, HG; Young, MB; Zhu, H; Munshi, S; Kuo, L; McGaughey, GB; Colussi, D; Crouthamel, MC; Lai, MT; Pietrak, B; Price, EA; Sankaranarayanan, S; Simon, AJ; Seabrook, GR; Hazuda, DJ; Pudvah, NT; Hochman, JH; Graham, SL; Vacca, JP; Nantermet, PG	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212189&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44441743	104088203		CHEMBL401180				ZINC28950044	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409073	CCCCCC(C)(C)NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(NCC)cc(c1)N1CCCC1=O	InChI=1S/C31H46N4O3/c1-5-7-11-16-31(3,4)33-22-28(36)27(18-23-13-9-8-10-14-23)34-30(38)24-19-25(32-6-2)21-26(20-24)35-17-12-15-29(35)37/h8-10,13-14,19-21,27-28,32-33,36H,5-7,11-12,15-18,22H2,1-4H3,(H,34,38)/t27-,28+/m0/s1	SZYBPAXICZXZGW-WUFINQPMSA-N	50231687	3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(2-methylheptan-2-ylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL252459	Beta-secretase 2			 30200							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231687	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231687&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446201	104055254		CHEMBL252459				ZINC28978407	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409077	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1ccccc1OC)N1CCCC1=O	InChI=1S/C31H38N4O4/c1-3-33-25-17-24(18-26(19-25)35-15-9-14-30(35)37)31(38)34-27(16-22-10-5-4-6-11-22)28(36)21-32-20-23-12-7-8-13-29(23)39-2/h4-8,10-13,17-19,27-28,32-33,36H,3,9,14-16,20-21H2,1-2H3,(H,34,38)/t27-,28+/m0/s1	PTIGXNFGODXOBH-WUFINQPMSA-N	50231693	CHEMBL429668::N-((2S,3R)-4-(2-methoxybenzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 44670							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231693	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231693&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10369729	104055260		CHEMBL429668				ZINC28978429	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409081	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC(F)(F)F)c1)N1CCCC1=O	InChI=1S/C31H35F3N4O4/c1-2-36-24-16-23(17-25(18-24)38-13-7-12-29(38)40)30(41)37-27(15-21-8-4-3-5-9-21)28(39)20-35-19-22-10-6-11-26(14-22)42-31(32,33)34/h3-6,8-11,14,16-18,27-28,35-36,39H,2,7,12-13,15,19-20H2,1H3,(H,37,41)/t27-,28+/m0/s1	QNEVJIWNSZTEGF-WUFINQPMSA-N	50231694	CHEMBL402348::N-((2S,3R)-4-(3-(trifluoromethoxy)benzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 2000							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231694	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231694&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10415909	104055261		CHEMBL402348				ZINC28978585	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409085	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCC1CCCCC1)N1CCCC1=O	InChI=1S/C30H42N4O3/c1-2-32-25-17-24(18-26(19-25)34-15-9-14-29(34)36)30(37)33-27(16-22-10-5-3-6-11-22)28(35)21-31-20-23-12-7-4-8-13-23/h3,5-6,10-11,17-19,23,27-28,31-32,35H,2,4,7-9,12-16,20-21H2,1H3,(H,33,37)/t27-,28+/m0/s1	CLVVTNIMNXEYMC-WUFINQPMSA-N	50231696	CHEMBL252262::N-((2S,3R)-4-(cyclohexylmethylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 57540							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231696	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231696&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446199	104055263		CHEMBL252262				ZINC28978389	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409090	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1ccc(OC)cc1)N1CCCC1=O	InChI=1S/C31H38N4O4/c1-3-33-25-17-24(18-26(19-25)35-15-7-10-30(35)37)31(38)34-28(16-22-8-5-4-6-9-22)29(36)21-32-20-23-11-13-27(39-2)14-12-23/h4-6,8-9,11-14,17-19,28-29,32-33,36H,3,7,10,15-16,20-21H2,1-2H3,(H,34,38)/t28-,29+/m0/s1	VPCVRIRYKSQLQR-URLMMPGGSA-N	50231695	CHEMBL404500::N-((2S,3R)-4-(4-methoxybenzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			>10							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231695	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231695&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			9984485	104055262		CHEMBL404500				ZINC28978434	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409091	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C27H37N3O5S/c1-19(26(32)29-22-13-7-4-8-14-22)28-18-25(31)24(16-20-10-5-3-6-11-20)30-27(33)21-12-9-15-23(17-21)36(2,34)35/h3,5-6,9-12,15,17,19,22,24-25,28,31H,4,7-8,13-14,16,18H2,1-2H3,(H,29,32)(H,30,33)/t19-,24-,25+/m0/s1	YKYXAHIQYWIJPR-PNTFMKQHSA-N	50231691	CHEMBL402120::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(methylsulfonyl)benzamide	Beta-secretase 2			 41770							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231691	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231691&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446196	104055258		CHEMBL402120				ZINC28978356	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409104	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1ccccc1)N1CCCC1=O	InChI=1S/C30H36N4O3/c1-2-32-25-17-24(18-26(19-25)34-15-9-14-29(34)36)30(37)33-27(16-22-10-5-3-6-11-22)28(35)21-31-20-23-12-7-4-8-13-23/h3-8,10-13,17-19,27-28,31-32,35H,2,9,14-16,20-21H2,1H3,(H,33,37)/t27-,28+/m0/s1	QJHJEVHSBAUDFK-WUFINQPMSA-N	50231699	CHEMBL252860::N-((2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 63100							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231699	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231699&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10391277	104055266		CHEMBL252860				ZINC28978423	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409111	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cc(OC)cc(OC)c1)N1CCCC1=O	InChI=1S/C32H40N4O5/c1-4-34-25-16-24(17-26(18-25)36-12-8-11-31(36)38)32(39)35-29(15-22-9-6-5-7-10-22)30(37)21-33-20-23-13-27(40-2)19-28(14-23)41-3/h5-7,9-10,13-14,16-19,29-30,33-34,37H,4,8,11-12,15,20-21H2,1-3H3,(H,35,39)/t29-,30+/m0/s1	YREYFYQYLVEDKG-XZWHSSHBSA-N	50231686	CHEMBL403820::N-((2S,3R)-4-(3,5-dimethoxybenzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 6920							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231686	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231686&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446210	104055253		CHEMBL403820				ZINC28978597	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409113	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNc1ccccc1)N1CCCC1=O	InChI=1S/C29H34N4O3/c1-2-30-24-17-22(18-25(19-24)33-15-9-14-28(33)35)29(36)32-26(16-21-10-5-3-6-11-21)27(34)20-31-23-12-7-4-8-13-23/h3-8,10-13,17-19,26-27,30-31,34H,2,9,14-16,20H2,1H3,(H,32,36)/t26-,27+/m0/s1	SFMOCUPWKLWIBH-RRPNLBNLSA-N	50231681	3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(phenylamino)butan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL252861	Beta-secretase 2			 21380							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231681	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231681&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446204	104055248		CHEMBL252861				ZINC28978438	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409116	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H]1CCc2ccccc12)N1CCCC1=O	InChI=1S/C32H38N4O3/c1-2-33-25-18-24(19-26(20-25)36-16-8-13-31(36)38)32(39)35-29(17-22-9-4-3-5-10-22)30(37)21-34-28-15-14-23-11-6-7-12-27(23)28/h3-7,9-12,18-20,28-30,33-34,37H,2,8,13-17,21H2,1H3,(H,35,39)/t28-,29+,30-/m1/s1	NLSNSOOHLJWWBV-DYIKCSJPSA-N	50231692	CHEMBL252495::N-((2S,3R)-4-((R)-2,3-dihydro-1H-inden-1-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide::TCMDC-132414	Beta-secretase 2			 93330							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231692	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231692&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446207	104055259		CHEMBL252495				ZINC28978451	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409118	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)CCCC(C)C)N1CCCC1=O	InChI=1S/C31H46N4O3/c1-5-32-26-18-25(19-27(20-26)35-16-10-15-30(35)37)31(38)34-28(17-24-13-7-6-8-14-24)29(36)21-33-23(4)12-9-11-22(2)3/h6-8,13-14,18-20,22-23,28-29,32-33,36H,5,9-12,15-17,21H2,1-4H3,(H,34,38)/t23?,28-,29+/m0/s1	KEYMCXPYOIICBR-DBUNYZNWSA-N	50231698	3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(6-methylheptan-2-ylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL252263	Beta-secretase 2			 3090							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231698	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231698&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446200	104055265		CHEMBL252263				ZINC28978399	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409124	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCCC1)N1CCCC1=O	InChI=1S/C30H42N4O3/c1-2-31-25-18-23(19-26(20-25)34-16-10-15-29(34)36)30(37)33-27(17-22-11-6-5-7-12-22)28(35)21-32-24-13-8-3-4-9-14-24/h5-7,11-12,18-20,24,27-28,31-32,35H,2-4,8-10,13-17,21H2,1H3,(H,33,37)/t27-,28+/m0/s1	MWGLTIRECTZMSF-WUFINQPMSA-N	50231674	CHEMBL430400::N-((2S,3R)-4-(cycloheptylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 12020							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231674	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231674&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446197	104055241		CHEMBL430400				ZINC28978376	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409126	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)n1)N1CCCC1=O	InChI=1S/C30H37N5O4/c1-3-32-24-16-22(17-25(18-24)35-14-8-13-29(35)37)30(38)34-26(15-21-9-5-4-6-10-21)27(36)20-31-19-23-11-7-12-28(33-23)39-2/h4-7,9-12,16-18,26-27,31-32,36H,3,8,13-15,19-20H2,1-2H3,(H,34,38)/t26-,27+/m0/s1	NBDKAUCCFLDJRV-RRPNLBNLSA-N	50231677	3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-((6-methoxypyridin-2-yl)methylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL254138	Beta-secretase 2			 33100							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231677	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231677&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446211	104055244		CHEMBL254138				ZINC28978601	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409128	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCCc1ccccc1)N1CCCC1=O	InChI=1S/C31H38N4O3/c1-2-33-26-19-25(20-27(21-26)35-17-9-14-30(35)37)31(38)34-28(18-24-12-7-4-8-13-24)29(36)22-32-16-15-23-10-5-3-6-11-23/h3-8,10-13,19-21,28-29,32-33,36H,2,9,14-18,22H2,1H3,(H,34,38)/t28-,29+/m0/s1	SRVJEHDGKSXUGW-URLMMPGGSA-N	50231697	3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL404501	Beta-secretase 2			 3390							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231697	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231697&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446205	104055264		CHEMBL404501				ZINC28978442	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50408945	NC(=N)NC(=O)Cn1c(ccc1-c1ccccc1)-c1ccccc1	InChI=1S/C19H18N4O/c20-19(21)22-18(24)13-23-16(14-7-3-1-4-8-14)11-12-17(23)15-9-5-2-6-10-15/h1-12H,13H2,(H4,20,21,22,24)	WVLDNAVUCUAGDP-UHFFFAOYSA-N	16751	(N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-acetamide)::Acylguanidine, 7a::CHEMBL217068::N-(diaminomethylidene)-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide	Beta-secretase 2			>50000							ChEMBL	10.1016/j.bmcl.2007.12.010	10.7270/Q22807CT	18162398			Cole, DC; Stock, JR; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jennings, LD; Jin, G; Lohse, PA; Malamas, MS; Manas, ES; Moore, WJ; O'Donnell, MM; Olland, AM; Robichaud, AJ; Svenson, K; Wu, J; Wagner, E; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16751&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	251	2QU2	11290116	46516971		CHEMBL217068	DB06930			ZINC14962105	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50408956	NC(=N)NC(=O)Cn1c(ccc1-c1ccc(NC(=O)c2cccc(Br)c2)cc1)-c1ccccc1	InChI=1S/C26H22BrN5O2/c27-20-8-4-7-19(15-20)25(34)30-21-11-9-18(10-12-21)23-14-13-22(17-5-2-1-3-6-17)32(23)16-24(33)31-26(28)29/h1-15H,16H2,(H,30,34)(H4,28,29,31,33)	XWWAMKGNSKOVNS-UHFFFAOYSA-N	50231481	3-bromo-N-(4-(1-(2-guanidino-2-oxoethyl)-5-phenyl-1H-pyrrol-2-yl)phenyl)benzamide::3-bromo-N-[4-[1-(2-carbamimidamido-2-oxo-ethyl)-5-phenyl-pyrrol-2-yl]phenyl]benzamide::3-bromo-N-{4-[1-(2-guanidino-2-oxo-ethyl)-5-phenyl-1H-pyrrol-2-yl]-phenyl}-benzamide::CHEMBL252189	Beta-secretase 2			 500							ChEMBL	10.1016/j.bmcl.2007.12.010	10.7270/Q22807CT	18162398			Cole, DC; Stock, JR; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jennings, LD; Jin, G; Lohse, PA; Malamas, MS; Manas, ES; Moore, WJ; O'Donnell, MM; Olland, AM; Robichaud, AJ; Svenson, K; Wu, J; Wagner, E; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231481	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231481&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	411	2ZE1	11606008	104055180		CHEMBL252189				ZINC29040179	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50408977	CC(=O)c1ccc(Oc2ccc(cc2)-c2ccc(-c3ccccc3Cl)n2CC(=O)NC(N)=N)cc1	InChI=1S/C27H23ClN4O3/c1-17(33)18-6-10-20(11-7-18)35-21-12-8-19(9-13-21)24-14-15-25(22-4-2-3-5-23(22)28)32(24)16-26(34)31-27(29)30/h2-15H,16H2,1H3,(H4,29,30,31,34)	MIEKBLPHNQZVQQ-UHFFFAOYSA-N	16753	2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl]-1H-pyrrol-1-yl]-N-(diaminomethylidene)acetamide::Acylguanidine, 7c::CHEMBL253237::N-{2-[2-[4-(4-Acetyl-phenoxy)-phenyl]-5-(2-chloro-phenyl)-pyrrol-1-yl]-acetyl}-guanidine	Beta-secretase 2			 2300							ChEMBL	10.1016/j.bmcl.2007.12.010	10.7270/Q22807CT	18162398			Cole, DC; Stock, JR; Chopra, R; Cowling, R; Ellingboe, JW; Fan, KY; Harrison, BL; Hu, Y; Jacobsen, S; Jennings, LD; Jin, G; Lohse, PA; Malamas, MS; Manas, ES; Moore, WJ; O'Donnell, MM; Olland, AM; Robichaud, AJ; Svenson, K; Wu, J; Wagner, E; Bard, J	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16753&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	310	2ZDZ	11583947	46516973		CHEMBL253237				ZINC14962112	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409042	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cnn(CC)c1)N1CCCC1=O	InChI=1S/C29H38N6O3/c1-3-31-24-14-23(15-25(16-24)35-12-8-11-28(35)37)29(38)33-26(13-21-9-6-5-7-10-21)27(36)19-30-17-22-18-32-34(4-2)20-22/h5-7,9-10,14-16,18,20,26-27,30-31,36H,3-4,8,11-13,17,19H2,1-2H3,(H,33,38)/t26-,27+/m0/s1	VQBBFJFTEHVVJZ-RRPNLBNLSA-N	50231673	CHEMBL402171::N-((2S,3R)-4-((1-ethyl-1H-pyrazol-4-yl)methylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 33110							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231673&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446212	104055240		CHEMBL402171				ZINC28978605	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409043	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCC1)N1CCCC1=O	InChI=1S/C28H38N4O3/c1-2-29-23-16-21(17-24(18-23)32-14-8-13-27(32)34)28(35)31-25(15-20-9-4-3-5-10-20)26(33)19-30-22-11-6-7-12-22/h3-5,9-10,16-18,22,25-26,29-30,33H,2,6-8,11-15,19H2,1H3,(H,31,35)/t25-,26+/m0/s1	NTZXVJXVQDVOLV-IZZNHLLZSA-N	50231675	CHEMBL402122::N-((2S,3R)-4-(cyclopentylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide::TCMDC-138844	Beta-secretase 2			 41690							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231675	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231675&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10073810	104055242		CHEMBL402122				ZINC28978380	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409044	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1(CCCCC1)c1cccc(OC)c1)N1CCCC1=O	InChI=1S/C36H46N4O4/c1-3-37-29-21-27(22-30(24-29)40-19-11-16-34(40)42)35(43)39-32(20-26-12-6-4-7-13-26)33(41)25-38-36(17-8-5-9-18-36)28-14-10-15-31(23-28)44-2/h4,6-7,10,12-15,21-24,32-33,37-38,41H,3,5,8-9,11,16-20,25H2,1-2H3,(H,39,43)/t32-,33+/m0/s1	WSYWLGZDHCWXRB-JHOUSYSJSA-N	50231676	3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-(3-methoxyphenyl)cyclohexylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL403427	Beta-secretase 2			 370							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231676	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231676&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24882477	104055243		CHEMBL403427				ZINC28978574	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409046	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCC1)N1CCCC1=O	InChI=1S/C29H40N4O3/c1-2-30-24-17-22(18-25(19-24)33-15-9-14-28(33)35)29(36)32-26(16-21-10-5-3-6-11-21)27(34)20-31-23-12-7-4-8-13-23/h3,5-6,10-11,17-19,23,26-27,30-31,34H,2,4,7-9,12-16,20H2,1H3,(H,32,36)/t26-,27+/m0/s1	PVDHVIVUNLQJLY-RRPNLBNLSA-N	50231678	CHEMBL252057::N-((2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide::N-[(1S,2R)-1-benzyl-3-(cyclohexylamino)-2-hydroxypropyl]-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 5010							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231678	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231678&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG7	2VJ9	9983140	104055245		CHEMBL252057				ZINC13133641	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409047	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCSCC1)N1CCCC1=O	InChI=1S/C28H38N4O3S/c1-2-29-23-16-21(17-24(18-23)32-12-6-9-27(32)34)28(35)31-25(15-20-7-4-3-5-8-20)26(33)19-30-22-10-13-36-14-11-22/h3-5,7-8,16-18,22,25-26,29-30,33H,2,6,9-15,19H2,1H3,(H,31,35)/t25-,26+/m0/s1	JKMKQSJNAYENGT-IZZNHLLZSA-N	50231679	3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(tetrahydro-2H-thiopyran-4-ylamino)butan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL252058	Beta-secretase 2			 5890							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231679	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231679&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446198	104055246		CHEMBL252058				ZINC28978385	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409048	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(OC)c1)N1CCCC1=O	InChI=1S/C31H38N4O4/c1-3-33-25-17-24(18-26(19-25)35-14-8-13-30(35)37)31(38)34-28(16-22-9-5-4-6-10-22)29(36)21-32-20-23-11-7-12-27(15-23)39-2/h4-7,9-12,15,17-19,28-29,32-33,36H,3,8,13-14,16,20-21H2,1-2H3,(H,34,38)/t28-,29+/m0/s1	ANZORHSSNYTZOP-URLMMPGGSA-N	50231680	CHEMBL252656::N-((2S,3R)-4-(3-methoxybenzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 7590							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231680	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231680&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10348155	104055247		CHEMBL252656				ZINC28978417	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409049	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)COCC(C)C)N1CCCC1=O	InChI=1S/C31H46N4O4/c1-6-32-25-16-24(17-26(18-25)35-14-10-13-29(35)37)30(38)34-27(15-23-11-8-7-9-12-23)28(36)19-33-31(4,5)21-39-20-22(2)3/h7-9,11-12,16-18,22,27-28,32-33,36H,6,10,13-15,19-21H2,1-5H3,(H,34,38)/t27-,28+/m0/s1	DXLLAPMROUKAHN-WUFINQPMSA-N	50231683	3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-isobutoxy-2-methylpropan-2-ylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL252655	Beta-secretase 2			 69010							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231683	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231683&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446202	104055250		CHEMBL252655				ZINC28978412	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409053	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCCCCC(C)C)N1CCCC1=O	InChI=1S/C30H44N4O3/c1-4-32-25-18-24(19-26(20-25)34-16-10-14-29(34)36)30(37)33-27(17-23-12-6-5-7-13-23)28(35)21-31-15-9-8-11-22(2)3/h5-7,12-13,18-20,22,27-28,31-32,35H,4,8-11,14-17,21H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	KDFMFNIYGTUGIZ-WUFINQPMSA-N	50231684	3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(5-methylhexylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL428587	Beta-secretase 2			 3610							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231684	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231684&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10324013	104055251		CHEMBL428587				ZINC28978402	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409055	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)c1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C33H39F3N4O3/c1-4-37-26-17-23(18-27(20-26)40-15-9-14-30(40)42)31(43)39-28(16-22-10-6-5-7-11-22)29(41)21-38-32(2,3)24-12-8-13-25(19-24)33(34,35)36/h5-8,10-13,17-20,28-29,37-38,41H,4,9,14-16,21H2,1-3H3,(H,39,43)/t28-,29+/m0/s1	ZDVISXXOPXEHTP-URLMMPGGSA-N	50231685	3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-(3-(trifluoromethyl)phenyl)propan-2-ylamino)butan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide::CHEMBL403207	Beta-secretase 2			 600							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231685	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231685&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446203	104055252		CHEMBL403207				ZINC28978425	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409058	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C32H45N5O4/c1-3-33-26-18-24(19-27(20-26)37-16-10-15-30(37)39)32(41)36-28(17-23-11-6-4-7-12-23)29(38)21-34-22(2)31(40)35-25-13-8-5-9-14-25/h4,6-7,11-12,18-20,22,25,28-29,33-34,38H,3,5,8-10,13-17,21H2,1-2H3,(H,35,40)(H,36,41)/t22-,28-,29+/m0/s1	ARWMRRUIIHCDKG-PWUSVURUSA-N	50231682	CHEMBL251862::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 1810							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231682	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231682&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG5	2XFJ,2VJ6	24882338	104055249		CHEMBL251862				ZINC28978361	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409062	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)CCCC(C)C)N1CCCC1=O	InChI=1S/C32H48N4O3/c1-6-33-26-19-25(20-27(21-26)36-17-11-15-30(36)38)31(39)35-28(18-24-13-8-7-9-14-24)29(37)22-34-32(4,5)16-10-12-23(2)3/h7-9,13-14,19-21,23,28-29,33-34,37H,6,10-12,15-18,22H2,1-5H3,(H,35,39)/t28-,29+/m0/s1	BNTVCVCCNARYIP-URLMMPGGSA-N	50231688	CHEMBL252458::N-((2S,3R)-4-(2,6-dimethylheptan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide::N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(1,1,5-trimethylhexyl)amino]propyl}-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 5890							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231688	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231688&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG0	2VIE	23657802	104055255		CHEMBL252458				ZINC16052608	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409064	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C31H35F3N4O3/c1-2-36-25-16-23(17-26(18-25)38-13-7-12-29(38)40)30(41)37-27(15-21-8-4-3-5-9-21)28(39)20-35-19-22-10-6-11-24(14-22)31(32,33)34/h3-6,8-11,14,16-18,27-28,35-36,39H,2,7,12-13,15,19-20H2,1H3,(H,37,41)/t27-,28+/m0/s1	QPGDTFHILHXFBQ-WUFINQPMSA-N	29756	CHEMBL403429::hydroxyethylamine derivative, 6	Beta-secretase 2			 4070							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29756&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG6	2VJ7	10008157	85147522		CHEMBL403429				ZINC16052618	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409065	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(Cl)c1)N1CCCC1=O	InChI=1S/C30H35ClN4O3/c1-2-33-25-16-23(17-26(18-25)35-13-7-12-29(35)37)30(38)34-27(15-21-8-4-3-5-9-21)28(36)20-32-19-22-10-6-11-24(31)14-22/h3-6,8-11,14,16-18,27-28,32-33,36H,2,7,12-13,15,19-20H2,1H3,(H,34,38)/t27-,28+/m0/s1	ZYPHKMBWKDJJOF-WUFINQPMSA-N	50231689	CHEMBL253719::N-((2S,3R)-4-(3-chlorobenzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 15140							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231689	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231689&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446209	104055256		CHEMBL253719				ZINC28978595	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50409067	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CCc2ccccc12)N1CCCC1=O	InChI=1S/C32H38N4O3/c1-2-33-25-18-24(19-26(20-25)36-16-8-13-31(36)38)32(39)35-29(17-22-9-4-3-5-10-22)30(37)21-34-28-15-14-23-11-6-7-12-27(23)28/h3-7,9-12,18-20,28-30,33-34,37H,2,8,13-17,21H2,1H3,(H,35,39)/t28-,29-,30+/m0/s1	NLSNSOOHLJWWBV-OIFRRMEBSA-N	50231690	CHEMBL253060::N-((2S,3R)-4-((S)-2,3-dihydro-1H-inden-1-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide::TCMDC-138917	Beta-secretase 2			 3720							ChEMBL	10.1016/j.bmcl.2007.12.019	10.7270/Q2J67GP2	18166458			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231690	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231690&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446206	104055257		CHEMBL253060				ZINC28978447	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50414585	CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@@H]1NCCN(Cc2ccccc2)C1=O	InChI=1S/C35H42F2N4O4/c1-4-12-40(13-5-2)34(44)27-16-23(3)15-26(20-27)33(43)39-30(19-25-17-28(36)21-29(37)18-25)32(42)31-35(45)41(14-11-38-31)22-24-9-7-6-8-10-24/h6-10,15-18,20-21,30-32,38,42H,4-5,11-14,19,22H2,1-3H3,(H,39,43)/t30-,31-,32-/m0/s1	XKXGRRZAMDHVGR-CPCREDONSA-N	50271626	CHEMBL509210::N'-[(1S,2S)-2-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide::N1-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-5-methyl-N3,N3-dipropylisophthalamide	Beta-secretase 2			 22							ChEMBL	10.1016/j.bmcl.2008.04.050	10.7270/Q2PZ58MR	18468890			Cumming, JN; Le, TX; Babu, S; Carroll, C; Chen, X; Favreau, L; Gaspari, P; Guo, T; Hobbs, DW; Huang, Y; Iserloh, U; Kennedy, ME; Kuvelkar, R; Li, G; Lowrie, J; McHugh, NA; Ozgur, L; Pan, J; Parker, EM; Saionz, K; Stamford, AW; Strickland, C; Tadesse, D; Voigt, J; Wang, L; Wu, Y; Zhang, L; Zhang, Q	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271626&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	316	3CIC	24808497	104116347		CHEMBL509210				ZINC24975929	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50414588	CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@@H]1NCN(Cc2ccccc2)C1=O	InChI=1S/C34H40F2N4O4/c1-4-11-39(12-5-2)33(43)26-14-22(3)13-25(18-26)32(42)38-29(17-24-15-27(35)19-28(36)16-24)31(41)30-34(44)40(21-37-30)20-23-9-7-6-8-10-23/h6-10,13-16,18-19,29-31,37,41H,4-5,11-12,17,20-21H2,1-3H3,(H,38,42)/t29-,30-,31-/m0/s1	HZWNNIVRFLRAQW-CHQNGUEUSA-N	50271627	CHEMBL507651::N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoimidazolidin-4-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide::N1-((1S,2S)-1-((S)-1-benzyl-5-oxoimidazolidin-4-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-5-methyl-N3,N3-dipropylisophthalamide	Beta-secretase 2			 51							ChEMBL	10.1016/j.bmcl.2008.04.050	10.7270/Q2PZ58MR	18468890			Cumming, JN; Le, TX; Babu, S; Carroll, C; Chen, X; Favreau, L; Gaspari, P; Guo, T; Hobbs, DW; Huang, Y; Iserloh, U; Kennedy, ME; Kuvelkar, R; Li, G; Lowrie, J; McHugh, NA; Ozgur, L; Pan, J; Parker, EM; Saionz, K; Stamford, AW; Strickland, C; Tadesse, D; Voigt, J; Wang, L; Wu, Y; Zhang, L; Zhang, Q	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271627&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	318	3CID	11520033	104116348		CHEMBL507651				ZINC24975881	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440310	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C31H38N4O5S/c1-21(23-12-8-5-9-13-23)33-30(37)24-17-25(19-27(18-24)35(2)41(3,39)40)31(38)34-28(16-22-10-6-4-7-11-22)29(36)20-32-26-14-15-26/h4-13,17-19,21,26,28-29,32,36H,14-16,20H2,1-3H3,(H,33,37)(H,34,38)/t21-,28+,29-/m1/s1	VPNIQGRFZCTBEZ-SPTGULJVSA-N	16034	1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::5-Substituted isophthalamide, 1::CHEMBL378225::Isophthalamide Derivative 24::L-000384950::N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxypropyl]-5-[methyl(methylsulfonyl)amino]-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide::hydroxyethylamine (HEA) derived inhibitor 1	Beta-secretase 2			 132							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16034&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	5HA	3TPP,3TPR,2B8L	5287532	46516301		CHEMBL378225				ZINC14960423	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440311	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N1CCCS1(=O)=O)c1ccccc1	InChI=1S/C32H38N4O5S/c1-22(24-11-6-3-7-12-24)34-31(38)25-18-26(20-28(19-25)36-15-8-16-42(36,40)41)32(39)35-29(17-23-9-4-2-5-10-23)30(37)21-33-27-13-14-27/h2-7,9-12,18-20,22,27,29-30,33,37H,8,13-17,21H2,1H3,(H,34,38)(H,35,39)/t22-,29+,30-/m1/s1	MBKQDBPGZVELFG-ZDERHKTGSA-N	50254711	CHEMBL443087::N-((1S,2R)-1-Benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-N'-((R)-1-phenyl-ethyl)-isophthalamide	Beta-secretase 2			 141							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254711	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254711&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570211	104106879		CHEMBL443087				ZINC44280585	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440313	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)N1CCCCS1(=O)=O)c1ccccc1	InChI=1S/C33H40N4O5S/c1-23(25-12-6-3-7-13-25)35-32(39)26-19-27(21-29(20-26)37-16-8-9-17-43(37,41)42)33(40)36-30(18-24-10-4-2-5-11-24)31(38)22-34-28-14-15-28/h2-7,10-13,19-21,23,28,30-31,34,38H,8-9,14-18,22H2,1H3,(H,35,39)(H,36,40)/t23-,30+,31-/m1/s1	BQAAFVLWSABVAL-YYSPBGNDSA-N	50254712	CHEMBL499468::N-((1S,2R)-1-Benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-N'-((R)-1-phenyl-ethyl)-isophthalamide	Beta-secretase 2			 251							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254712&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570212	104106880		CHEMBL499468				ZINC49889407	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440325	C[C@@H](NC(=O)c1cc(cc2OCCCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccc(F)cc1	InChI=1S/C33H38FN3O4/c1-21(23-10-12-25(34)13-11-23)36-33(40)28-18-24(19-31-27(28)9-5-6-16-41-31)32(39)37-29(17-22-7-3-2-4-8-22)30(38)20-35-26-14-15-26/h2-4,7-8,10-13,18-19,21,26,29-30,35,38H,5-6,9,14-17,20H2,1H3,(H,36,40)(H,37,39)/t21-,29+,30-/m1/s1	WCHANTAGLXCTLE-HAQLSYKPSA-N	50254746	CHEMBL446879::N8-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N6-((R)-1-(4-fluorophenyl)ethyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-6,8-dicarboxamide	Beta-secretase 2			 1949							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254746&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570262	104106909		CHEMBL446879				ZINC44305782	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440326	C[C@@H](NC(=O)c1cc(cc2OCCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccc(F)cc1	InChI=1S/C32H36FN3O4/c1-20(22-9-11-24(33)12-10-22)35-32(39)27-17-23(18-30-26(27)8-5-15-40-30)31(38)36-28(16-21-6-3-2-4-7-21)29(37)19-34-25-13-14-25/h2-4,6-7,9-12,17-18,20,25,28-29,34,37H,5,8,13-16,19H2,1H3,(H,35,39)(H,36,38)/t20-,28+,29-/m1/s1	BOCRENYPEJKZOM-IEXUNWISSA-N	50254745	CHEMBL463864::N7-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N5-((R)-1-(4-fluorophenyl)ethyl)chroman-5,7-dicarboxamide	Beta-secretase 2			 2089							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254745&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570261	104106908		CHEMBL463864				ZINC44387948	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440330	COc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)C(=O)N[C@H](C)c1ccccc1	InChI=1S/C30H35N3O4/c1-20(22-11-7-4-8-12-22)32-29(35)23-16-24(18-26(17-23)37-2)30(36)33-27(15-21-9-5-3-6-10-21)28(34)19-31-25-13-14-25/h3-12,16-18,20,25,27-28,31,34H,13-15,19H2,1-2H3,(H,32,35)(H,33,36)/t20-,27+,28-/m1/s1	GKRKKPGYGQZJMG-JTOILGAVSA-N	50254666	CHEMBL479421::N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-methoxy-N3-((R)-1-phenylethyl)isophthalamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254666	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254666&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570173	104106841		CHEMBL479421				ZINC40936555	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440331	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)C#C)c1ccccc1	InChI=1S/C31H33N3O3/c1-3-22-16-25(30(36)33-21(2)24-12-8-5-9-13-24)19-26(17-22)31(37)34-28(18-23-10-6-4-7-11-23)29(35)20-32-27-14-15-27/h1,4-13,16-17,19,21,27-29,32,35H,14-15,18,20H2,2H3,(H,33,36)(H,34,37)/t21-,28+,29-/m1/s1	RPKVMUQEUBVMQP-SPTGULJVSA-N	50254667	CHEMBL518294::N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-ethynyl-N3-((R)-1-phenylethyl)isophthalamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254667	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254667&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570174	104106842		CHEMBL518294				ZINC40936557	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440332	C[C@@H](NC(=O)c1cc(cc(c1)-c1ccsc1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C33H35N3O3S/c1-22(24-10-6-3-7-11-24)35-32(38)27-17-26(25-14-15-40-21-25)18-28(19-27)33(39)36-30(16-23-8-4-2-5-9-23)31(37)20-34-29-12-13-29/h2-11,14-15,17-19,21-22,29-31,34,37H,12-13,16,20H2,1H3,(H,35,38)(H,36,39)/t22-,30+,31-/m1/s1	ZTEDLWSRZQXJSK-QSSDJRQSSA-N	50254707	CHEMBL473652::N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-phenylethyl)-5-(thiophen-3-yl)isophthalamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254707	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254707&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570207	104106875		CHEMBL473652				ZINC44417782	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440333	C[C@@H](NC(=O)c1cc(cc(c1)-c1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C35H36ClN3O3/c1-23(25-10-6-3-7-11-25)38-34(41)28-19-27(26-12-14-30(36)15-13-26)20-29(21-28)35(42)39-32(18-24-8-4-2-5-9-24)33(40)22-37-31-16-17-31/h2-15,19-21,23,31-33,37,40H,16-18,22H2,1H3,(H,38,41)(H,39,42)/t23-,32+,33-/m1/s1	BKWNRLGMNHZAMD-UMJMCJBLSA-N	50254708	4'-Chloro-biphenyl-3,5-dicarboxylic acid 3-[((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-amide] 5-[((R)-1-phenyl-ethyl)-amide]::CHEMBL443447	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254708	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254708&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570208	104106876		CHEMBL443447				ZINC44281110	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440334	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)C#Cc1ccccc1)c1ccccc1	InChI=1S/C37H37N3O3/c1-26(30-15-9-4-10-16-30)39-36(42)31-21-29(18-17-27-11-5-2-6-12-27)22-32(24-31)37(43)40-34(23-28-13-7-3-8-14-28)35(41)25-38-33-19-20-33/h2-16,21-22,24,26,33-35,38,41H,19-20,23,25H2,1H3,(H,39,42)(H,40,43)/t26-,34+,35-/m1/s1	WBARRWBVYQMDQH-PTWIYLDJSA-N	50254709	CHEMBL450801::N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-phenylethyl)-5-(2-phenylethynyl)isophthalamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254709	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254709&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570209	104106877		CHEMBL450801				ZINC44352171	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440335	C[C@@H](NC(=O)c1cc(cc(c1)-c1cn(Cc2ccccc2)nn1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C38H40N6O3/c1-26(29-15-9-4-10-16-29)40-37(46)31-20-30(35-25-44(43-42-35)24-28-13-7-3-8-14-28)21-32(22-31)38(47)41-34(19-27-11-5-2-6-12-27)36(45)23-39-33-17-18-33/h2-16,20-22,25-26,33-34,36,39,45H,17-19,23-24H2,1H3,(H,40,46)(H,41,47)/t26-,34+,36-/m1/s1	YTMYFBOYXMHHME-OUJNJVGLSA-N	50254710	5-(1-benzyl-1H-1,2,3-triazol-4-yl)-N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-phenylethyl)isophthalamide::CHEMBL449578	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570210	104106878		CHEMBL449578				ZINC44351903	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50445784	CC(C)(C)OC(=O)N1C[C@H](Nc2nc3cc(F)ccc3[nH]2)[C@H](C1)OC(=O)c1ccc(cc1)-c1ccccc1	InChI=1S/C29H29FN4O4/c1-29(2,3)38-28(36)34-16-24(33-27-31-22-14-13-21(30)15-23(22)32-27)25(17-34)37-26(35)20-11-9-19(10-12-20)18-7-5-4-6-8-18/h4-15,24-25H,16-17H2,1-3H3,(H2,31,32,33)/t24-,25-/m0/s1	ONXOLONSBJTOEF-DQEYMECFSA-N	50134794	CHEMBL3746637	Beta-secretase 2			 10100							ChEMBL	10.1016/j.bmcl.2015.11.033	10.7270/Q2BC41CC	26608551			De Tran, Q; Bepary, S; Lee, GH; Cho, H; Park, WK; Lim, HJ	Korea University of Science and Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134794&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72946738	336951669		CHEMBL3746637					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50445785	CC(C)c1ccc(cc1)C(=O)O[C@H]1CN(C[C@@H]1Nc1nc2cc(F)ccc2[nH]1)C(=O)OC(C)(C)C	InChI=1S/C26H31FN4O4/c1-15(2)16-6-8-17(9-7-16)23(32)34-22-14-31(25(33)35-26(3,4)5)13-21(22)30-24-28-19-11-10-18(27)12-20(19)29-24/h6-12,15,21-22H,13-14H2,1-5H3,(H2,28,29,30)/t21-,22-/m0/s1	OWXJEEIJHWOZKB-VXKWHMMOSA-N	50134818	CHEMBL3746261	Beta-secretase 2			 4400							ChEMBL	10.1016/j.bmcl.2015.11.033	10.7270/Q2BC41CC	26608551			De Tran, Q; Bepary, S; Lee, GH; Cho, H; Park, WK; Lim, HJ	Korea University of Science and Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134818&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72946943	336951672		CHEMBL3746261					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50445786	Cc1ccc2[nH]c(N[C@H]3CNC[C@@H]3OC(=O)c3ccc(cc3)-c3ccccc3)nc2c1	InChI=1S/C25H24N4O2/c1-16-7-12-20-21(13-16)28-25(27-20)29-22-14-26-15-23(22)31-24(30)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-13,22-23,26H,14-15H2,1H3,(H2,27,28,29)/t22-,23-/m0/s1	GHIKRRXJYNSNNF-GOTSBHOMSA-N	50134822	CHEMBL3745922	Beta-secretase 2			 4300							ChEMBL	10.1016/j.bmcl.2015.11.033	10.7270/Q2BC41CC	26608551			De Tran, Q; Bepary, S; Lee, GH; Cho, H; Park, WK; Lim, HJ	Korea University of Science and Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134822	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134822&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72946535	336951676		CHEMBL3745922					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50445787	Cc1ccc2[nH]c(N[C@H]3CN(C[C@@H]3OC(=O)c3ccc(cc3)-c3ccccc3)C(=O)c3ccccc3)nc2c1	InChI=1S/C32H28N4O3/c1-21-12-17-26-27(18-21)34-32(33-26)35-28-19-36(30(37)24-10-6-3-7-11-24)20-29(28)39-31(38)25-15-13-23(14-16-25)22-8-4-2-5-9-22/h2-18,28-29H,19-20H2,1H3,(H2,33,34,35)/t28-,29-/m0/s1	RFWJOTSSJGFXMU-VMPREFPWSA-N	50134824	CHEMBL3747556	Beta-secretase 2			 5700							ChEMBL	10.1016/j.bmcl.2015.11.033	10.7270/Q2BC41CC	26608551			De Tran, Q; Bepary, S; Lee, GH; Cho, H; Park, WK; Lim, HJ	Korea University of Science and Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134824	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134824&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72946537	336951678		CHEMBL3747556					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50445788	CC(C)(C)OC(=O)N1C[C@H](Nc2nc3cc(F)ccc3[nH]2)[C@H](C1)OCc1ccc(cc1)-c1ccccc1	InChI=1S/C29H31FN4O3/c1-29(2,3)37-28(35)34-16-25(33-27-31-23-14-13-22(30)15-24(23)32-27)26(17-34)36-18-19-9-11-21(12-10-19)20-7-5-4-6-8-20/h4-15,25-26H,16-18H2,1-3H3,(H2,31,32,33)/t25-,26-/m0/s1	ISSOLUDHEZMZKW-UIOOFZCWSA-N	50134917	CHEMBL3747766	Beta-secretase 2			 8900							ChEMBL	10.1016/j.bmcl.2015.11.033	10.7270/Q2BC41CC	26608551			De Tran, Q; Bepary, S; Lee, GH; Cho, H; Park, WK; Lim, HJ	Korea University of Science and Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134917&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			72947373	104025412		CHEMBL3747766				ZINC43910233	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440336	C[C@@H](NC(=O)c1cc(cc2oc(C)cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C32H35N3O4/c1-20-15-26-27(32(38)34-21(2)23-11-7-4-8-12-23)17-24(18-30(26)39-20)31(37)35-28(16-22-9-5-3-6-10-22)29(36)19-33-25-13-14-25/h3-12,15,17-18,21,25,28-29,33,36H,13-14,16,19H2,1-2H3,(H,34,38)(H,35,37)/t21-,28+,29-/m1/s1	DULHFOZITVQSGH-SPTGULJVSA-N	50254713	CHEMBL514310::N6-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-methyl-N4-((R)-1-phenylethyl)benzofuran-4,6-dicarboxamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254713&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570213	104106881		CHEMBL514310				ZINC42875258	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440337	C[C@@H](NC(=O)c1cc(cc2OCCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C32H37N3O4/c1-21(23-11-6-3-7-12-23)34-32(38)27-18-24(19-30-26(27)13-8-16-39-30)31(37)35-28(17-22-9-4-2-5-10-22)29(36)20-33-25-14-15-25/h2-7,9-12,18-19,21,25,28-29,33,36H,8,13-17,20H2,1H3,(H,34,38)(H,35,37)/t21-,28+,29-/m1/s1	QVCPGZYJEIDVFT-SPTGULJVSA-N	50254714	CHEMBL473854::N7-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N5-((R)-1-phenylethyl)chroman-5,7-dicarboxamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254714	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254714&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25181420	104106882		CHEMBL473854				ZINC44430363	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440338	C[C@@H](NC(=O)c1cc(cc2OCCCCc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C33H39N3O4/c1-22(24-12-6-3-7-13-24)35-33(39)28-19-25(20-31-27(28)14-8-9-17-40-31)32(38)36-29(18-23-10-4-2-5-11-23)30(37)21-34-26-15-16-26/h2-7,10-13,19-20,22,26,29-30,34,37H,8-9,14-18,21H2,1H3,(H,35,39)(H,36,38)/t22-,29+,30-/m1/s1	LXIQBYCJDRSMAU-ZDERHKTGSA-N	50254744	CHEMBL474057::N8-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N6-((R)-1-phenylethyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-6,8-dicarboxamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254744	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254744&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25181421	104106907		CHEMBL474057				ZINC44430573	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440339	C[C@@H](NC(=O)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC2CC2)c2cc(C)oc2c1)c1ccccc1	InChI=1S/C32H35N3O4/c1-20-15-26-27(17-24(18-30(26)39-20)31(37)34-21(2)23-11-7-4-8-12-23)32(38)35-28(16-22-9-5-3-6-10-22)29(36)19-33-25-13-14-25/h3-12,15,17-18,21,25,28-29,33,36H,13-14,16,19H2,1-2H3,(H,34,37)(H,35,38)/t21-,28+,29-/m1/s1	RYLYLEZYSLPXSS-SPTGULJVSA-N	50254747	CHEMBL463865::N4-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-methyl-N6-((R)-1-phenylethyl)benzofuran-4,6-dicarboxamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254747&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570263	104106910		CHEMBL463865				ZINC44387952	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440340	C[C@@H](NC(=O)c1cc2OCCCc2c(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C32H37N3O4/c1-21(23-11-6-3-7-12-23)34-31(37)24-18-27(26-13-8-16-39-30(26)19-24)32(38)35-28(17-22-9-4-2-5-10-22)29(36)20-33-25-14-15-25/h2-7,9-12,18-19,21,25,28-29,33,36H,8,13-17,20H2,1H3,(H,34,37)(H,35,38)/t21-,28+,29-/m1/s1	HQIFKDQCICONGY-SPTGULJVSA-N	50254784	CHEMBL517179::N5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N7-((R)-1-phenylethyl)chroman-5,7-dicarboxamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254784&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570302	104106935		CHEMBL517179				ZINC42877526	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440341	C[C@@H](NC(=O)c1cc2OCCCCc2c(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C33H39N3O4/c1-22(24-12-6-3-7-13-24)35-32(38)25-19-28(27-14-8-9-17-40-31(27)20-25)33(39)36-29(18-23-10-4-2-5-11-23)30(37)21-34-26-15-16-26/h2-7,10-13,19-20,22,26,29-30,34,37H,8-9,14-18,21H2,1H3,(H,35,38)(H,36,39)/t22-,29+,30-/m1/s1	PPVOCDQWTXFBHU-ZDERHKTGSA-N	50254785	CHEMBL464918::N6-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N8-((R)-1-phenylethyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-6,8-dicarboxamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254785&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570303	104106936		CHEMBL464918				ZINC44405020	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50440342	C[C@@H](NC(=O)c1cc(O)cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)c1ccccc1	InChI=1S/C29H33N3O4/c1-19(21-10-6-3-7-11-21)31-28(35)22-15-23(17-25(33)16-22)29(36)32-26(14-20-8-4-2-5-9-20)27(34)18-30-24-12-13-24/h2-11,15-17,19,24,26-27,30,33-34H,12-14,18H2,1H3,(H,31,35)(H,32,36)/t19-,26+,27-/m1/s1	JYSDETLSPPVSOQ-PGMDNKBISA-N	50254665	CHEMBL482371::N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-hydroxy-N3-((R)-1-phenylethyl)isophthalamide	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2008.10.096	10.7270/Q2ZP4606	19013792			Chirapu, SR; Pachaiyappan, B; Nural, HF; Cheng, X; Yuan, H; Lankin, DC; Abdul-Hay, SO; Thatcher, GR; Shen, Y; Kozikowski, AP; Petukhov, PA	University of Illinois at Chicago	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254665	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254665&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44570172	104106840		CHEMBL482371				ZINC40934070	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50456056	CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CS(C)(=O)=O)NC(=O)OCn1nc(C)cc1C)C(C)C	InChI=1S/C30H54N6O8S/c1-17(2)11-23(25(37)12-20(7)27(38)34-26(19(5)6)29(40)31-14-18(3)4)32-28(39)24(15-45(10,42)43)33-30(41)44-16-36-22(9)13-21(8)35-36/h13,17-20,23-26,37H,11-12,14-16H2,1-10H3,(H,31,40)(H,32,39)(H,33,41)(H,34,38)/t20-,23+,24+,25+,26+/m1/s1	OFAZWNGNAATRSH-GWCXRDAXSA-N	16253	(3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-[(2-methylpropyl)carbamoyl]propyl]carbamoyl}heptan-4-yl]carbamoyl}-2-methanesulfonylethyl]carbamate::CHEMBL448008::N2-[(2R,4S,5S)-5-{[N-{[(3,5-dimethyl-1H-pyrazol-1-yl)methoxy]carbonyl}-3-(methylsulfonyl)-L-alanyl]amino}-4-hydroxy-2,7-dimethyloctanoyl]-N-(2-methylpropyl)-L-valinamide::pyrazole-bearing inhibitor 5	Beta-secretase 2		 356								ChEMBL	10.1021/jm900064c	10.7270/Q2KS6RF1	19323561			Ghosh, AK	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	ZPQ	2G94	6540293	46509499		CHEMBL448008				ZINC24805568	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50456059	CC(C)CNC(=O)[C@@H](NC(=O)[C@H](C)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CS(C)(=O)=O)NC(=O)OCc1nc(C)oc1C)C(C)C	InChI=1S/C30H53N5O9S/c1-16(2)11-22(25(36)12-19(7)27(37)35-26(18(5)6)29(39)31-13-17(3)4)33-28(38)24(15-45(10,41)42)34-30(40)43-14-23-20(8)44-21(9)32-23/h16-19,22,24-26,36H,11-15H2,1-10H3,(H,31,39)(H,33,38)(H,34,40)(H,35,37)/t19-,22+,24+,25+,26+/m1/s1	UDROXIDKAFGJQP-ACAMQMCKSA-N	16254	(2,5-dimethyl-1,3-oxazol-4-yl)methyl N-[(1R)-1-{[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-[(2-methylpropyl)carbamoyl]propyl]carbamoyl}heptan-4-yl]carbamoyl}-2-methanesulfonylethyl]carbamate::CHEMBL449300::N2-[(2R,4S,5S)-5-{[N-{[(2,5-dimethyl-1,3-oxazol-4-yl)methoxy]carbonyl}-3-(methylsulfonyl)-L-alanyl]amino}-4-hydroxy-2,7-dimethyloctanoyl]-N-(2-methylpropyl)-L-valinamide::oxazolylmethyl-bearing inhibitor 6	Beta-secretase 2		 458								ChEMBL	10.1021/jm900064c	10.7270/Q2KS6RF1	19323561			Ghosh, AK	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11498384	46516314		CHEMBL449300				ZINC49841211	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543012	CN1C(N)=NC(C1=O)(c1ccccc1)C12CC3CC(CC(C3)C1)C2	InChI=1S/C20H25N3O/c1-23-17(24)20(22-18(23)21,16-5-3-2-4-6-16)19-10-13-7-14(11-19)9-15(8-13)12-19/h2-6,13-15H,7-12H2,1H3,(H2,21,22)	BEDDENNXVBITIQ-UHFFFAOYSA-N	50303718	5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dihydro-imidazol-4-one::CHEMBL585952	Beta-secretase 2			 830							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303718&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	593	3IND	16050640	104158079		CHEMBL585952				ZINC34948295	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543013	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C23H22N4O2/c1-15-12-19(9-10-20(15)29-3)23(21(28)27(2)22(24)26-23)18-8-4-6-16(13-18)17-7-5-11-25-14-17/h4-14H,1-3H3,(H2,24,26)	TWVGNKMRZLBNOD-UHFFFAOYSA-N	50303719	2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566200::rac-2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 780							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303719&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	X45	3INF	11516577	104158080		CHEMBL566200				ZINC45245214	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543024	CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)c1cccc(-c2cncnc2)c1F	InChI=1S/C21H15F4N5O2/c1-30-18(31)20(29-19(30)26,13-5-7-14(8-6-13)32-21(23,24)25)16-4-2-3-15(17(16)22)12-9-27-11-28-10-12/h2-11H,1H3,(H2,26,29)	GYXAUJZSDKKZRQ-UHFFFAOYSA-N	50303729	2-amino-4-(2-fluoro-3-(pyrimidin-5-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566404	Beta-secretase 2			 5040							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303729	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303729&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488110	104158090		CHEMBL566404				ZINC45245101	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543030	COc1ncccc1-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccc(OC(F)(F)F)cc1	InChI=1S/C23H19F3N4O3/c1-30-20(31)22(29-21(30)27,15-8-10-17(11-9-15)33-23(24,25)26)16-6-3-5-14(13-16)18-7-4-12-28-19(18)32-2/h3-13H,1-2H3,(H2,27,29)	KERCJRSYQSWRIP-UHFFFAOYSA-N	50303735	2-amino-4-(3-(2-methoxypyridin-3-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL567259	Beta-secretase 2			 5990							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303735	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303735&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488112	104158096		CHEMBL567259				ZINC45252937	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543032	CCCCOc1ccc(cc1)C1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C24H33N3O2/c1-3-4-9-29-20-7-5-19(6-8-20)24(21(28)27(2)22(25)26-24)23-13-16-10-17(14-23)12-18(11-16)15-23/h5-8,16-18H,3-4,9-15H2,1-2H3,(H2,25,26)	JJIVIBNFUQPABT-UHFFFAOYSA-N	50303737	5-Adamantan-1-yl-2-amino-5-(4-butoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL585286	Beta-secretase 2			 5550							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303737&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050552	104158098		CHEMBL585286				ZINC34948158	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543034	CCOc1ccc(cc1)C1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C22H29N3O2/c1-3-27-18-6-4-17(5-7-18)22(19(26)25(2)20(23)24-22)21-11-14-8-15(12-21)10-16(9-14)13-21/h4-7,14-16H,3,8-13H2,1-2H3,(H2,23,24)	LOQLIYCILQUEKV-UHFFFAOYSA-N	50303721	5-Adamantan-1-yl-2-amino-5-(4-ethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL566198	Beta-secretase 2			 2530							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303721	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303721&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050551	104158082		CHEMBL566198				ZINC34948154	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543035	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C22H21N5O2/c1-14-9-18(7-8-19(14)29-3)22(20(28)27(2)21(23)26-22)17-6-4-5-15(10-17)16-11-24-13-25-12-16/h4-13H,1-3H3,(H2,23,26)	NJDRPIPNXBADEH-UHFFFAOYSA-N	50303739	2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyrimidin-5-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566012	Beta-secretase 2			 1590							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303739&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11668187	104158100		CHEMBL566012				ZINC38215394	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543038	COc1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccccc1	InChI=1S/C17H17N3O2/c1-20-15(21)17(19-16(20)18,12-7-4-3-5-8-12)13-9-6-10-14(11-13)22-2/h3-11H,1-2H3,(H2,18,19)	BNTCTQFWBJMVDZ-UHFFFAOYSA-N	50303740	2-amino-4-(3-methoxyphenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL576628	Beta-secretase 2			 1190							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303740	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303740&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488109	104158101		CHEMBL576628				ZINC45290914	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543040	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cncnc1	InChI=1S/C22H20FN5O2/c1-13-8-15(5-7-19(13)30-3)22(20(29)28(2)21(24)27-22)16-4-6-18(23)17(9-16)14-10-25-12-26-11-14/h4-12H,1-3H3,(H2,24,27)	IRDBIIRYCSZMEB-UHFFFAOYSA-N	50303716	2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL567688	Beta-secretase 2			 2800							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303716	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303716&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11517020	104158077		CHEMBL567688				ZINC43103523	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543044	COc1ccc(cc1OC)C1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C22H29N3O3/c1-25-19(26)22(24-20(25)23,16-4-5-17(27-2)18(9-16)28-3)21-10-13-6-14(11-21)8-15(7-13)12-21/h4-5,9,13-15H,6-8,10-12H2,1-3H3,(H2,23,24)	UOXQVRHHHXEQIR-UHFFFAOYSA-N	50303742	5-Adamantan-1-yl-2-amino-5-(3,4-dimethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL567485	Beta-secretase 2			 9590							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303742&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050641	104158103		CHEMBL567485				ZINC34948299	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543045	CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)C12CC3CC(CC(C3)C1)C2	InChI=1S/C21H24F3N3O2/c1-27-17(28)20(26-18(27)25,15-2-4-16(5-3-15)29-21(22,23)24)19-9-12-6-13(10-19)8-14(7-12)11-19/h2-5,12-14H,6-11H2,1H3,(H2,25,26)	KKUVYLRKCGXDSS-UHFFFAOYSA-N	50303732	5-Adamantan-1-yl-2-amino-3-methyl-5-(4-trifluoromethoxy-phenyl)-3,5-diydro-imidazol-4-one::CHEMBL583899	Beta-secretase 2			 3870							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303732&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488101	104158093		CHEMBL583899				ZINC45317151	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543046	COc1ccc(cc1OC(C)C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C25H26N4O3/c1-16(2)32-22-14-20(10-11-21(22)31-4)25(23(30)29(3)24(26)28-25)19-9-5-7-17(13-19)18-8-6-12-27-15-18/h5-16H,1-4H3,(H2,26,28)	WTQARMXDFIUYMM-UHFFFAOYSA-N	50303723	2-amino-4-(3-isopropoxy-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL567687	Beta-secretase 2			 1840							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303723	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303723&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11539235	104158084		CHEMBL567687				ZINC34630726	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543047	COc1ccc(cn1)-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccc(OC(F)(F)F)cc1	InChI=1S/C23H19F3N4O3/c1-30-20(31)22(29-21(30)27,16-7-9-18(10-8-16)33-23(24,25)26)17-5-3-4-14(12-17)15-6-11-19(32-2)28-13-15/h3-13H,1-2H3,(H2,27,29)	FPLFNFQJKPTNSQ-UHFFFAOYSA-N	50303730	2-amino-4-(3-(6-methoxypyridin-3-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566212	Beta-secretase 2			 2510							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303730	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303730&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488116	104158091		CHEMBL566212				ZINC45245824	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543055	COc1ccc(cc1OC)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C23H22N4O3/c1-27-21(28)23(26-22(27)24,18-9-10-19(29-2)20(13-18)30-3)17-8-4-6-15(12-17)16-7-5-11-25-14-16/h4-14H,1-3H3,(H2,24,26)	VJMOHDYSQCGYSS-UHFFFAOYSA-N	50303733	2-amino-4-(3,4-dimethoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566403	Beta-secretase 2			 4170							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303733&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11589453	104158094		CHEMBL566403				ZINC35878767	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543069	CCCCOc1cc(ccc1OC)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C26H28N4O3/c1-4-5-14-33-23-16-21(11-12-22(23)32-3)26(24(31)30(2)25(27)29-26)20-10-6-8-18(15-20)19-9-7-13-28-17-19/h6-13,15-17H,4-5,14H2,1-3H3,(H2,27,29)	YGOMBZILOXVUMF-UHFFFAOYSA-N	50303752	2-amino-4-(3-butoxy-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL567061	Beta-secretase 2			 170							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303752&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11510567	104158113		CHEMBL567061				ZINC45245860	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543070	COc1ccc(cc1C(F)(F)F)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C23H19F3N4O2/c1-30-20(31)22(29-21(30)27,17-8-9-19(32-2)18(12-17)23(24,25)26)16-7-3-5-14(11-16)15-6-4-10-28-13-15/h3-13H,1-2H3,(H2,27,29)	WKDSDPYPMAYPSN-UHFFFAOYSA-N	50303738	2-amino-4-(4-methoxy-3-(trifluoromethyl)phenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL585289	Beta-secretase 2			 1000							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303738&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11532248	104158099		CHEMBL585289				ZINC45320983	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543080	CCN1C(N)=NC(C1=O)(c1ccccc1)c1ccccc1	InChI=1S/C17H17N3O/c1-2-20-15(21)17(19-16(20)18,13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12H,2H2,1H3,(H2,18,19)	NAIMLLJOOQROJZ-UHFFFAOYSA-N	50303753	2-amino-1-ethyl-4,4-diphenyl-1H-imidazol-5(4H)-one::CHEMBL567053	Beta-secretase 2			 5160							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303753&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488103	104158114		CHEMBL567053				ZINC45245611	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543081	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)(F)F)cc1)c1ccc(F)c(c1)-c1cncnc1	InChI=1S/C21H15F4N5O2/c1-30-18(31)20(29-19(30)26,13-2-5-15(6-3-13)32-21(23,24)25)14-4-7-17(22)16(8-14)12-9-27-11-28-10-12/h2-11H,1H3,(H2,26,29)/t20-/m1/s1	RNJTYVPMRSKRKE-HXUWFJFHSA-N	50303731	(5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one::(R)-2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL568115	Beta-secretase 2			 9690							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	569	3INH	11539562	104158092		CHEMBL568115				ZINC34631070	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543083	COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C22H29N3O2/c1-13-6-17(4-5-18(13)27-3)22(19(26)25(2)20(23)24-22)21-10-14-7-15(11-21)9-16(8-14)12-21/h4-6,14-16H,7-12H2,1-3H3,(H2,23,24)/t14?,15?,16?,21?,22-/m0/s1	HZIOSWLCMNAEBB-RCRNZYILSA-N	50303734	(S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL571320	Beta-secretase 2			 6290							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303734&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	X17	3INE	45488104	104158095		CHEMBL571320				ZINC45283585	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543102	CCOc1cc(ccc1OC)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C24H24N4O3/c1-4-31-21-14-19(10-11-20(21)30-3)24(22(29)28(2)23(25)27-24)18-9-5-7-16(13-18)17-8-6-12-26-15-17/h5-15H,4H2,1-3H3,(H2,25,27)	DXWZHAPHEZJJSL-UHFFFAOYSA-N	50303749	2-amino-4-(3-ethoxy-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566406	Beta-secretase 2			 600							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303749	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303749&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11611402	104158110		CHEMBL566406				ZINC35933312	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543106	CN1C(N)=NC(C1=O)(c1ccccc1)c1ccc(Cl)cc1	InChI=1S/C16H14ClN3O/c1-20-14(21)16(19-15(20)18,11-5-3-2-4-6-11)12-7-9-13(17)10-8-12/h2-10H,1H3,(H2,18,19)	UKYITZHCXATSAD-UHFFFAOYSA-N	50303741	2-amino-4-(4-chlorophenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL566007	Beta-secretase 2			 1840							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303741&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488115	104158102		CHEMBL566007				ZINC45245813	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543124	COc1ccc(cc1OC1CCCC1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C27H28N4O3/c1-31-25(32)27(30-26(31)28,20-9-5-7-18(15-20)19-8-6-14-29-17-19)21-12-13-23(33-2)24(16-21)34-22-10-3-4-11-22/h5-9,12-17,22H,3-4,10-11H2,1-2H3,(H2,28,30)	SPQJQLMNHCRQEE-UHFFFAOYSA-N	50303744	2-amino-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566638	Beta-secretase 2			 300							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303744	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303744&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11633904	104158105		CHEMBL566638				ZINC35972124	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543125	CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)c1cc(F)cc(c1)-c1cncnc1	InChI=1S/C21H15F4N5O2/c1-30-18(31)20(29-19(30)26,14-2-4-17(5-3-14)32-21(23,24)25)15-6-12(7-16(22)8-15)13-9-27-11-28-10-13/h2-11H,1H3,(H2,26,29)	SWJSIMOUBCDDJW-UHFFFAOYSA-N	50303743	2-amino-4-(3-fluoro-5-(pyrimidin-5-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566633	Beta-secretase 2			 1260							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303743	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303743&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488107	104158104		CHEMBL566633				ZINC45245843	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543131	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(C#N)c(c1)-c1cccnc1	InChI=1S/C24H21N5O2/c1-15-11-18(8-9-21(15)31-3)24(22(30)29(2)23(26)28-24)19-7-6-16(13-25)20(12-19)17-5-4-10-27-14-17/h4-12,14H,1-3H3,(H2,26,28)	ZPCHKGPANGLPQI-UHFFFAOYSA-N	50303725	4-(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)-2-(pyridin-3-yl)benzonitrile::CHEMBL565378	Beta-secretase 2			 2320							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303725&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11560610	104158086		CHEMBL565378				ZINC35817503	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543135	COc1ccc(cc1C1CCCC1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C27H28N4O2/c1-31-25(32)27(30-26(31)28,21-11-5-9-19(15-21)20-10-6-14-29-17-20)22-12-13-24(33-2)23(16-22)18-7-3-4-8-18/h5-6,9-18H,3-4,7-8H2,1-2H3,(H2,28,30)	LBTDLQNIKCPSHI-UHFFFAOYSA-N	50303724	2-amino-4-(3-cyclopentyl-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL565790	Beta-secretase 2			 960							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303724	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303724&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11553983	104158085		CHEMBL565790				ZINC35801399	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543136	CN1C(N)=NC(C1=O)(c1cccc(c1)-c1cccnc1)c1ccc2OCCOc2c1	InChI=1S/C23H20N4O3/c1-27-21(28)23(26-22(27)24,18-7-8-19-20(13-18)30-11-10-29-19)17-6-2-4-15(12-17)16-5-3-9-25-14-16/h2-9,12-14H,10-11H2,1H3,(H2,24,26)	ZREWWVASMZJDGY-UHFFFAOYSA-N	50303751	2-amino-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL584917	Beta-secretase 2			 500							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303751&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11654224	104158112		CHEMBL584917				ZINC45318235	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543140	CCCOc1cc(ccc1OC)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C25H26N4O3/c1-4-13-32-22-15-20(10-11-21(22)31-3)25(23(30)29(2)24(26)28-25)19-9-5-7-17(14-19)18-8-6-12-27-16-18/h5-12,14-16H,4,13H2,1-3H3,(H2,26,28)	YYSJAHZDJKNFJF-UHFFFAOYSA-N	50303722	2-amino-4-(4-methoxy-3-propoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566407	Beta-secretase 2			 200							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303722	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303722&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11654876	104158083		CHEMBL566407				ZINC45245223	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543141	COc1ccc(cc1F)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C22H19FN4O2/c1-27-20(28)22(26-21(27)24,17-8-9-19(29-2)18(23)12-17)16-7-3-5-14(11-16)15-6-4-10-25-13-15/h3-13H,1-2H3,(H2,24,26)	YWRKDNPWZYLYMH-UHFFFAOYSA-N	50303745	2-amino-4-(3-fluoro-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566223	Beta-secretase 2			 520							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303745&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11632510	104158106		CHEMBL566223				ZINC35967805	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543145	COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F	InChI=1S/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/m1/s1	JIBQVJZSWQNHLX-HSZRJFAPSA-N	50303727	(4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL584695	Beta-secretase 2			 1840							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303727&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488105	104158088		CHEMBL584695				ZINC43152619	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543148	CN1C(N)=NC(C1=O)(c1ccccc1)c1ccccc1	InChI=1S/C16H15N3O/c1-19-14(20)16(18-15(19)17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11H,1H3,(H2,17,18)	RNWLAFWLSSMCLN-UHFFFAOYSA-N	50300229	1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine::2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one::2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-one::5,5-Diphenyl-2-iminohydantoin::CHEMBL291784	Beta-secretase 2			 770							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15054176	104154590		CHEMBL291784				ZINC29544241	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543152	COc1ccc(cc1)[C@@]1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C21H27N3O2/c1-24-18(25)21(23-19(24)22,16-3-5-17(26-2)6-4-16)20-10-13-7-14(11-20)9-15(8-13)12-20/h3-6,13-15H,7-12H2,1-2H3,(H2,22,23)/t13?,14?,15?,20?,21-/m0/s1	BGCGXOOJJMGOQV-CPGUEHHYSA-N	50303748	(S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL585128	Beta-secretase 2			 680							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303748&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488098	104158109		CHEMBL585128				ZINC34948148	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543154	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C23H21FN4O2/c1-14-12-17(9-10-19(14)30-3)23(21(29)28(2)22(25)27-23)16-7-4-6-15(13-16)18-8-5-11-26-20(18)24/h4-13H,1-3H3,(H2,25,27)	FZVZGKTWGPYMHW-UHFFFAOYSA-N	50303717	2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL566011::rac-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one	Beta-secretase 2			 780							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303717&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488119	104158078		CHEMBL566011				ZINC45246053	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543159	COc1ccc(cc1C#N)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C23H19N5O2/c1-28-21(29)23(27-22(28)25,19-8-9-20(30-2)17(12-19)13-24)18-7-3-5-15(11-18)16-6-4-10-26-14-16/h3-12,14H,1-2H3,(H2,25,27)	OHTIBTGUVJBMTO-UHFFFAOYSA-N	50303736	5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)phenyl)-4,5-dihydro-1H-imidazol-4-yl)-2-methoxybenzonitrile::CHEMBL568114	Beta-secretase 2			 550							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303736&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11639859	104158097		CHEMBL568114				ZINC35983589	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543160	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(C)c(c1)-c1cccnc1	InChI=1S/C24H24N4O2/c1-15-7-8-19(13-20(15)17-6-5-11-26-14-17)24(22(29)28(3)23(25)27-24)18-9-10-21(30-4)16(2)12-18/h5-14H,1-4H3,(H2,25,27)	AIBQLQGSZCUSCL-UHFFFAOYSA-N	50303720	2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(4-methyl-3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL565995	Beta-secretase 2			 960							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303720&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11538592	104158081		CHEMBL565995				ZINC34629567	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543166	COc1ccc(cc1C)[C@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F	InChI=1S/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/m0/s1	JIBQVJZSWQNHLX-QHCPKHFHSA-N	50303747	(4S)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL567477	Beta-secretase 2			 810							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303747&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44631933	104158108		CHEMBL567477				ZINC45253647	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543179	NC1=NC(C(=O)N1)(c1ccccc1)c1ccccc1	InChI=1S/C15H13N3O/c16-14-17-13(19)15(18-14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H3,16,17,18,19)	KMAGLUVYQQBXIR-UHFFFAOYSA-N	50303754	2-Imino-5,5-diphenyl-imidazolidin-4-one::2-amino-4,4-diphenyl-1H-imidazol-5(4H)-one::CHEMBL56002	Beta-secretase 2			 87190							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303754&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			213731	104158115		CHEMBL56002				ZINC12376028	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543180	CN1C(N)=NC(C1=O)(c1ccccc1)c1cccc(Cl)c1	InChI=1S/C16H14ClN3O/c1-20-14(21)16(19-15(20)18,11-6-3-2-4-7-11)12-8-5-9-13(17)10-12/h2-10H,1H3,(H2,18,19)	QWEOCJPATDOXQJ-UHFFFAOYSA-N	50303728	2-amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL578410	Beta-secretase 2			 420							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303728&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488113	104158089		CHEMBL578410				ZINC45290657	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543181	COc1ccc(cc1)C1(N=C(N)N(C)C1=O)c1ccccc1	InChI=1S/C17H17N3O2/c1-20-15(21)17(19-16(20)18,12-6-4-3-5-7-12)13-8-10-14(22-2)11-9-13/h3-11H,1-2H3,(H2,18,19)	VJOYOUKJSHACSN-UHFFFAOYSA-N	50303746	2-amino-4-(4-methoxyphenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL577905	Beta-secretase 2			 1720							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303746&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488114	104158107		CHEMBL577905				ZINC45291047	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543182	COc1ccc(cc1C)[C@]1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C22H29N3O2/c1-13-6-17(4-5-18(13)27-3)22(19(26)25(2)20(23)24-22)21-10-14-7-15(11-21)9-16(8-14)12-21/h4-6,14-16H,7-12H2,1-3H3,(H2,23,24)/t14?,15?,16?,21?,22-/m1/s1	HZIOSWLCMNAEBB-QVLKYBFXSA-N	50303755	(R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL585120	Beta-secretase 2			 73580							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303755	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303755&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488108	104158116		CHEMBL585120				ZINC45316628	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543183	CCc1cc(ccc1OC)C1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2	InChI=1S/C23H31N3O2/c1-4-17-10-18(5-6-19(17)28-3)23(20(27)26(2)21(24)25-23)22-11-14-7-15(12-22)9-16(8-14)13-22/h5-6,10,14-16H,4,7-9,11-13H2,1-3H3,(H2,24,25)	ZQVKNEMQAHETSD-UHFFFAOYSA-N	50303759	5-Adamantan-1-yl-2-amino-5-(3-ethyl-4-methoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL584109	Beta-secretase 2			 4330							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303759&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050553	104158120		CHEMBL584109				ZINC34948162	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543184	COc1ccc(cc1Cl)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C22H19ClN4O2/c1-27-20(28)22(26-21(27)24,17-8-9-19(29-2)18(23)12-17)16-7-3-5-14(11-16)15-6-4-10-25-13-15/h3-13H,1-2H3,(H2,24,26)	NBTCNBCWVKBTIT-UHFFFAOYSA-N	50303750	2-amino-4-(3-chloro-4-methoxyphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL565996	Beta-secretase 2			 560							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303750&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11545958	104158111		CHEMBL565996				ZINC34661182	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543185	CN1C(N)=NC(C1=O)(c1ccc2OCCc2c1)c1cccc(c1)-c1cccnc1	InChI=1S/C23H20N4O2/c1-27-21(28)23(26-22(27)24,19-7-8-20-16(13-19)9-11-29-20)18-6-2-4-15(12-18)17-5-3-10-25-14-17/h2-8,10,12-14H,9,11H2,1H3,(H2,24,26)	VACMQJOAIDVTHB-UHFFFAOYSA-N	50303758	2-amino-4-(2,3-dihydrobenzofuran-5-yl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566414	Beta-secretase 2			 1130							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303758	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303758&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11668120	104158119		CHEMBL566414				ZINC38215320	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543186	CN1C(N)=NC(C1=O)(c1ccc2OCOc2c1)c1cccc(c1)-c1cccnc1	InChI=1S/C22H18N4O3/c1-26-20(27)22(25-21(26)23,17-7-8-18-19(11-17)29-13-28-18)16-6-2-4-14(10-16)15-5-3-9-24-12-15/h2-12H,13H2,1H3,(H2,23,25)	XEGBNTCEGJZIPQ-UHFFFAOYSA-N	50303726	2-amino-4-(benzo[d][1,3]dioxol-5-yl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566415	Beta-secretase 2			 540							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303726	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303726&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11531131	104158087		CHEMBL566415				ZINC45245459	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543187	CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H16F4N4O2/c1-30-19(31)21(29-20(30)27,14-7-9-16(10-8-14)32-22(24,25)26)15-5-2-4-13(12-15)17-6-3-11-28-18(17)23/h2-12H,1H3,(H2,27,29)	JFVCKHOQNLFVNL-UHFFFAOYSA-N	50303757	2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL567258	Beta-secretase 2			 2480							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303757	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303757&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488111	104158118		CHEMBL567258				ZINC45246010	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50543188	CN1C(N)=N[C@@](C1=O)(c1ccc(OC(F)(F)F)cc1)c1ccc(F)c(c1)-c1cncnc1	InChI=1S/C21H15F4N5O2/c1-30-18(31)20(29-19(30)26,13-2-5-15(6-3-13)32-21(23,24)25)14-4-7-17(22)16(8-14)12-9-27-11-28-10-12/h2-11H,1H3,(H2,26,29)/t20-/m0/s1	RNJTYVPMRSKRKE-FQEVSTJZSA-N	50303756	(S)-2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566632	Beta-secretase 2			 9970							ChEMBL	10.1021/jm901414e	10.7270/Q2SX6DBS	19968289			Malamas, MS; Erdei, J; Gunawan, I; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Jacobsen, S; Magolda, RL; Pangalos, M; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303756&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488106	104158117		CHEMBL566632				ZINC43103532	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547236	CN1C(N)=NC(C2CCCCC2)(C1=O)c1cccc(NC(=O)c2ccco2)c1	InChI=1S/C21H24N4O3/c1-25-19(27)21(24-20(25)22,14-7-3-2-4-8-14)15-9-5-10-16(13-15)23-18(26)17-11-6-12-28-17/h5-6,9-14H,2-4,7-8H2,1H3,(H2,22,24)(H,23,26)	JSEJOHYXWOWWPR-UHFFFAOYSA-N	50305468	CHEMBL590829::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)furan-2-carboxamide	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305468	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305468&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051698	104159829		CHEMBL590829				ZINC34950041	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547237	CN1C(N)=NC(C2CCCCC2)(C1=O)c1cccc(NC(=O)c2occc2C)c1	InChI=1S/C22H26N4O3/c1-14-11-12-29-18(14)19(27)24-17-10-6-9-16(13-17)22(15-7-4-3-5-8-15)20(28)26(2)21(23)25-22/h6,9-13,15H,3-5,7-8H2,1-2H3,(H2,23,25)(H,24,27)	CZSNUKITORTJBZ-UHFFFAOYSA-N	50305469	CHEMBL590830::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)-3-methylfuran-2-carboxamide	Beta-secretase 2			 30							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305469	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305469&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051586	104159830		CHEMBL590830				ZINC34949859	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547238	CN1C(N)=NC(C2CCCCC2)(C1=O)c1cccc(NC(=O)c2cccn2C)c1	InChI=1S/C22H27N5O2/c1-26-13-7-12-18(26)19(28)24-17-11-6-10-16(14-17)22(15-8-4-3-5-9-15)20(29)27(2)21(23)25-22/h6-7,10-15H,3-5,8-9H2,1-2H3,(H2,23,25)(H,24,28)	BLPHJRSVVFXPQF-UHFFFAOYSA-N	50305470	CHEMBL591070::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)-1-methyl-1H-pyrrole-2-carboxamide	Beta-secretase 2			 180							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305470	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305470&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051696	104159831		CHEMBL591070				ZINC34950033	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547239	CCCC(=O)Nc1cccc(c1)C1(N=C(N)N(C)C1=O)C1CCCCC1	InChI=1S/C20H28N4O2/c1-3-8-17(25)22-16-12-7-11-15(13-16)20(14-9-5-4-6-10-14)18(26)24(2)19(21)23-20/h7,11-14H,3-6,8-10H2,1-2H3,(H2,21,23)(H,22,25)	AQMDTMDYMXRAFN-UHFFFAOYSA-N	50305471	CHEMBL595302::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)butyramide	Beta-secretase 2			 490							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305471	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305471&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46225238	104159832		CHEMBL595302				ZINC45349089	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547240	COCC(=O)Nc1cccc(c1)C1(N=C(N)N(C)C1=O)C1CCCCC1	InChI=1S/C19H26N4O3/c1-23-17(25)19(22-18(23)20,13-7-4-3-5-8-13)14-9-6-10-15(11-14)21-16(24)12-26-2/h6,9-11,13H,3-5,7-8,12H2,1-2H3,(H2,20,22)(H,21,24)	VAZKQVYVSGKYLY-UHFFFAOYSA-N	50305472	CHEMBL589614::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)-2-methoxyacetamide	Beta-secretase 2			 40							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305472&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051697	104159833		CHEMBL589614				ZINC34950037	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547241	COCCC(=O)Nc1cccc(c1)C1(N=C(N)N(C)C1=O)C1CCCCC1	InChI=1S/C20H28N4O3/c1-24-18(26)20(23-19(24)21,14-7-4-3-5-8-14)15-9-6-10-16(13-15)22-17(25)11-12-27-2/h6,9-10,13-14H,3-5,7-8,11-12H2,1-2H3,(H2,21,23)(H,22,25)	JKKLMAOQHPBFAO-UHFFFAOYSA-N	50305473	CHEMBL594656::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)-3-methoxypropanamide	Beta-secretase 2			 1850							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305473	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305473&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051584	104159834		CHEMBL594656				ZINC34949851	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547242	COc1cccc(c1)C(=O)Nc1cccc(c1)C1(N=C(N)N(C)C1=O)C1CCCCC1	InChI=1S/C24H28N4O3/c1-28-22(30)24(27-23(28)25,17-9-4-3-5-10-17)18-11-7-12-19(15-18)26-21(29)16-8-6-13-20(14-16)31-2/h6-8,11-15,17H,3-5,9-10H2,1-2H3,(H2,25,27)(H,26,29)	DMXXMELVGMWDME-UHFFFAOYSA-N	50305474	CHEMBL594896::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)-3-methoxybenzamide	Beta-secretase 2			 490							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305474&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051495	104159835		CHEMBL594896				ZINC34949743	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547243	CN1C(N)=NC(C2CCCCC2)(C1=O)c1cccc(NC(=O)c2ccc3OCOc3c2)c1	InChI=1S/C24H26N4O4/c1-28-22(30)24(27-23(28)25,16-6-3-2-4-7-16)17-8-5-9-18(13-17)26-21(29)15-10-11-19-20(12-15)32-14-31-19/h5,8-13,16H,2-4,6-7,14H2,1H3,(H2,25,27)(H,26,29)	SNQQSEHSNGCNKM-UHFFFAOYSA-N	50305475	CHEMBL605518::N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)benzo[d][1,3]dioxole-5-carboxamide	Beta-secretase 2			 1150							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305475	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305475&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46225290	104159836		CHEMBL605518				ZINC45384195	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547245	CCCCCCN1C(N)=NC(C2CCCCC2)(C1=O)c1ccccc1	InChI=1S/C21H31N3O/c1-2-3-4-11-16-24-19(25)21(23-20(24)22,17-12-7-5-8-13-17)18-14-9-6-10-15-18/h5,7-8,12-13,18H,2-4,6,9-11,14-16H2,1H3,(H2,22,23)	ASRKRRQDKDMWOY-UHFFFAOYSA-N	50305476	2-amino-4-cyclohexyl-1-hexyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL593979	Beta-secretase 2			 270							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305476	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305476&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051040	104159837		CHEMBL593979				ZINC34948999	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547247	NC1=NC(C2CCCCC2)(C(=O)N1CCCCCC(O)=O)c1ccccc1	InChI=1S/C21H29N3O3/c22-20-23-21(16-10-4-1-5-11-16,17-12-6-2-7-13-17)19(27)24(20)15-9-3-8-14-18(25)26/h1,4-5,10-11,17H,2-3,6-9,12-15H2,(H2,22,23)(H,25,26)	RRIUOHGQLUNAMR-UHFFFAOYSA-N	50305477	6-(2-amino-4-cyclohexyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-1-yl)hexanoic acid::CHEMBL607527	Beta-secretase 2			 310							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305477	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305477&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050938	104159838		CHEMBL607527				ZINC34948818	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547249	NC1=NC(C2CCCCC2)(C(=O)N1C[C@H]1CC[C@@H](CC1)C(O)=O)c1ccccc1	InChI=1S/C23H31N3O3/c24-22-25-23(18-7-3-1-4-8-18,19-9-5-2-6-10-19)21(29)26(22)15-16-11-13-17(14-12-16)20(27)28/h1,3-4,7-8,16-17,19H,2,5-6,9-15H2,(H2,24,25)(H,27,28)/t16-,17-,23?	VENODDRXHDEEEG-XEDXNJDHSA-N	50305478	4-((2-amino-4-cyclohexyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)cyclohexanecarboxylic acid::CHEMBL589891	Beta-secretase 2			 120							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305478&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050937	104159839		CHEMBL589891				ZINC34948814	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547252	NC1=NC(C2CCCCC2)(C(=O)N1Cc1cc(F)cc(F)c1)c1ccccc1	InChI=1S/C22H23F2N3O/c23-18-11-15(12-19(24)13-18)14-27-20(28)22(26-21(27)25,16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1,3-4,7-8,11-13,17H,2,5-6,9-10,14H2,(H2,25,26)	QUKQOEWZOAXBOR-UHFFFAOYSA-N	50305480	2-amino-4-cyclohexyl-1-(3,5-difluorobenzyl)-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL592533	Beta-secretase 2			 410							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305480&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050834	104159841		CHEMBL592533				ZINC34948616	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547254	NC1=NC(C2CCCCC2)(C(=O)N1CC1CCCO1)c1ccccc1	InChI=1S/C20H27N3O2/c21-19-22-20(15-8-3-1-4-9-15,16-10-5-2-6-11-16)18(24)23(19)14-17-12-7-13-25-17/h1,3-4,8-9,16-17H,2,5-7,10-14H2,(H2,21,22)	DWDSPZQJZVOFAW-UHFFFAOYSA-N	50305481	2-amino-4-cyclohexyl-4-phenyl-1-((tetrahydrofuran-2-yl)methyl)-1H-imidazol-5(4H)-one::CHEMBL592534	Beta-secretase 2			 170							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305481	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305481&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050932	104159842		CHEMBL592534				ZINC34948795	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547255	NC1=NC(C2CCCCC2)(C(=O)N1CCCO)c1ccccc1	InChI=1S/C18H25N3O2/c19-17-20-18(14-8-3-1-4-9-14,15-10-5-2-6-11-15)16(23)21(17)12-7-13-22/h1,3-4,8-9,15,22H,2,5-7,10-13H2,(H2,19,20)	DOBKRHKXKDKCIU-UHFFFAOYSA-N	50305482	2-amino-4-cyclohexyl-1-(3-hydroxypropyl)-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL605079	Beta-secretase 2			 1650							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305482	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305482&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050837	104159843		CHEMBL605079				ZINC34948626	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547258	NC1=NC(C2CCCCC2)(C(=O)N1Cc1ccccc1)c1ccccc1	InChI=1S/C22H25N3O/c23-21-24-22(18-12-6-2-7-13-18,19-14-8-3-9-15-19)20(26)25(21)16-17-10-4-1-5-11-17/h1-2,4-7,10-13,19H,3,8-9,14-16H2,(H2,23,24)	AZYGPVIFZHZTAH-UHFFFAOYSA-N	50305479	2-amino-1-benzyl-4-cyclohexyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL585215	Beta-secretase 2			 570							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305479&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16051038	104159840		CHEMBL585215				ZINC34948992	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547267	NC1=NC(C2=NCCCN12)(c1ccccc1)c1ccccc1	InChI=1S/C18H18N4/c19-17-21-18(14-8-3-1-4-9-14,15-10-5-2-6-11-15)16-20-12-7-13-22(16)17/h1-6,8-11H,7,12-13H2,(H2,19,21)	UFWSJOVQEPTPNE-UHFFFAOYSA-N	50300710	8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL582044	Beta-secretase 2			 38000							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	454	3IGB	11543843	104155071		CHEMBL582044				ZINC34657615	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547268	CN1C(N)=NC(C1=O)(c1ccccc1)c1ccccc1	InChI=1S/C16H15N3O/c1-19-14(20)16(18-15(19)17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11H,1H3,(H2,17,18)	RNWLAFWLSSMCLN-UHFFFAOYSA-N	50300229	1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine::2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one::2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-one::5,5-Diphenyl-2-iminohydantoin::CHEMBL291784	Beta-secretase 2			 770							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15054176	104154590		CHEMBL291784				ZINC29544241	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547269	CN1C(N)=NC(C2CCCCC2)(C1=O)c1ccccc1	InChI=1S/C16H21N3O/c1-19-14(20)16(18-15(19)17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2,4-5,8-9,13H,3,6-7,10-11H2,1H3,(H2,17,18)	FEZQZQTWDYTJPE-UHFFFAOYSA-N	50305467	2-amino-4-cyclohexyl-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL599965	Beta-secretase 2			 510							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305467	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305467&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16050931	104159828		CHEMBL599965				ZINC34948788	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50547270	CN1C(N)=NC(C2CCCCC2)(C2CCCCC2)C1=O	InChI=1S/C16H27N3O/c1-19-14(20)16(18-15(19)17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h12-13H,2-11H2,1H3,(H2,17,18)	IAMIFCZOYVOTFD-UHFFFAOYSA-N	50305483	2-amino-4,4-dicyclohexyl-1-methyl-1H-imidazol-5(4H)-one::CHEMBL589163	Beta-secretase 2			 510							ChEMBL	10.1016/j.bmcl.2009.11.052	10.7270/Q20Z73BN	19959359			Nowak, P; Cole, DC; Aulabaugh, A; Bard, J; Chopra, R; Cowling, R; Fan, KY; Hu, B; Jacobsen, S; Jani, M; Jin, G; Lo, MC; Malamas, MS; Manas, ES; Narasimhan, R; Reinhart, P; Robichaud, AJ; Stock, JR; Subrath, J; Svenson, K; Turner, J; Wagner, E; Zhou, P; Ellingboe, JW	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305483	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305483&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46225190	104159844		CHEMBL589163				ZINC45337578	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535883	CC1(C)CN2C(N)=NC(C2=N1)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C25H21F4N5O/c1-23(2)14-34-21(32-23)24(33-22(34)30,16-8-10-18(11-9-16)35-25(27,28)29)17-6-3-5-15(13-17)19-7-4-12-31-20(19)26/h3-13H,14H2,1-2H3,(H2,30,33)	TVENQKPJIUJCEH-UHFFFAOYSA-N	50300724	7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-(4-(trifluoromethoxy)phenyl)-3,7-dihydro-2H-imidazo[1,5-a]imidazol-5-amine::CHEMBL566548	Beta-secretase 2			 17300							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300724	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300724&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25184935	104155085		CHEMBL566548				ZINC45254026	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535884	NC1=NC(\C2=N\CCCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C26H23F4N5O/c27-22-21(8-5-14-32-22)17-6-4-7-19(16-17)25(18-9-11-20(12-10-18)36-26(28,29)30)23-33-13-2-1-3-15-35(23)24(31)34-25/h4-12,14,16H,1-3,13,15H2,(H2,31,34)/b33-23-	UFMYOISPMQWRNH-SNCSUOKWSA-N	50300712	10-(3-(2-fluoropyridin-3-yl)phenyl)-10-(4-(trifluoromethoxy)phenyl)-2,3,4,5,6,10-hexahydroimidazo[1,5-a][1,3]diazocin-8-amine::CHEMBL568960	Beta-secretase 2			 10800							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300712&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25184934	104155073		CHEMBL568960				ZINC45257242	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535885	NC1=NC(C2=NCCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C25H21F4N5O/c26-21-20(7-4-13-31-21)16-5-3-6-18(15-16)24(17-8-10-19(11-9-17)35-25(27,28)29)22-32-12-1-2-14-34(22)23(30)33-24/h3-11,13,15H,1-2,12,14H2,(H2,30,33)	AMHTVOUZASNVCQ-UHFFFAOYSA-N	50300713	9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoromethoxy)phenyl)-3,4,5,9-tetrahydro-2H-imidazo[1,5-a][1,3]diazepin-7-amine::CHEMBL565914	Beta-secretase 2			 7300							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300713&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25184936	104155074		CHEMBL565914				ZINC45253721	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535886	NC1=NC(C2=NCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C23H17F4N5O/c24-19-18(5-2-10-29-19)14-3-1-4-16(13-14)22(20-30-11-12-32(20)21(28)31-22)15-6-8-17(9-7-15)33-23(25,26)27/h1-10,13H,11-12H2,(H2,28,31)	ZASDNILYUCOUST-UHFFFAOYSA-N	50300714	7-(3-(2-fluoropyridin-3-yl)phenyl)-7-(4-(trifluoromethoxy)phenyl)-3,7-dihydro-2H-imidazo[1,5-a]imidazol-5-amine::CHEMBL566112	Beta-secretase 2			 12200							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300714	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300714&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25184937	104155075		CHEMBL566112				ZINC45246059	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535887	CCOc1ccc(cc1OCC)C1(N=C(N)N2CCCN=C12)c1cccc(c1)-c1cccnc1F	InChI=1S/C27H28FN5O2/c1-3-34-22-12-11-20(17-23(22)35-4-2)27(25-31-14-7-15-33(25)26(29)32-27)19-9-5-8-18(16-19)21-10-6-13-30-24(21)28/h5-6,8-13,16-17H,3-4,7,14-15H2,1-2H3,(H2,29,32)	TWIURROXDBTAGU-UHFFFAOYSA-N	50300715	8-(3,4-diethoxyphenyl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL566978	Beta-secretase 2			 9900							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300715	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300715&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44478656	104155076		CHEMBL566978				ZINC45245723	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535888	NC1=NC(C2=NCCCN12)(c1ccc2OCOc2c1)c1cccc(c1)-c1cccnc1F	InChI=1S/C24H20FN5O2/c25-21-18(6-2-9-27-21)15-4-1-5-16(12-15)24(17-7-8-19-20(13-17)32-14-31-19)22-28-10-3-11-30(22)23(26)29-24/h1-2,4-9,12-13H,3,10-11,14H2,(H2,26,29)	KRRNBJQBFJHWFJ-UHFFFAOYSA-N	50300718	8-(benzo[d][1,3]dioxol-5-yl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL583608	Beta-secretase 2			 4400							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300718&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44478659	104155079		CHEMBL583608				ZINC45320316	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535889	NC1=NC(C2=NCCCN12)(c1cccc(c1)-c1cccnc1F)c1ccc2OCCOc2c1	InChI=1S/C25H22FN5O2/c26-22-19(6-2-9-28-22)16-4-1-5-17(14-16)25(23-29-10-3-11-31(23)24(27)30-25)18-7-8-20-21(15-18)33-13-12-32-20/h1-2,4-9,14-15H,3,10-13H2,(H2,27,30)	WDVQMWDSGDTYIB-UHFFFAOYSA-N	50300717	8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL566968	Beta-secretase 2			 10500							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300717&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44478390	104155078		CHEMBL566968				ZINC45245271	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535890	NC1=N[C@@](C2=NCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C24H19F4N5O/c25-20-19(6-2-11-30-20)15-4-1-5-17(14-15)23(21-31-12-3-13-33(21)22(29)32-23)16-7-9-18(10-8-16)34-24(26,27)28/h1-2,4-11,14H,3,12-13H2,(H2,29,32)/t23-/m0/s1	OPSMDCTXTURNQW-QHCPKHFHSA-N	50300719	(8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL584509	Beta-secretase 2			 11400							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300719&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11655737	104155080		CHEMBL584509				ZINC35998747	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535891	COc1ccc(cc1)C1(N=C(N)N2CCCN=C12)c1cccc(c1)-c1cccnc1F	InChI=1S/C24H22FN5O/c1-31-19-10-8-17(9-11-19)24(22-28-13-4-14-30(22)23(26)29-24)18-6-2-5-16(15-18)20-7-3-12-27-21(20)25/h2-3,5-12,15H,4,13-14H2,1H3,(H2,26,29)	PIONCLLNBJJWDA-UHFFFAOYSA-N	50300720	8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-methoxyphenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL584267	Beta-secretase 2			 6600							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300720&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11633041	104155081		CHEMBL584267				ZINC35969003	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535892	NC1=NC(C2=NCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cncnc1	InChI=1S/C23H19F3N6O/c24-23(25,26)33-19-7-5-17(6-8-19)22(20-30-9-2-10-32(20)21(27)31-22)18-4-1-3-15(11-18)16-12-28-14-29-13-16/h1,3-8,11-14H,2,9-10H2,(H2,27,31)	FYQZYBSHWLRFKL-UHFFFAOYSA-N	50300725	8-(3-(pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL584521	Beta-secretase 2			 16700							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300725&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11510740	104155086		CHEMBL584521				ZINC45245626	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535893	NC1=NC(C2=NCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(CCC2CC2)c1	InChI=1S/C24H25F3N4O/c25-24(26,27)32-20-11-9-18(10-12-20)23(21-29-13-2-14-31(21)22(28)30-23)19-4-1-3-17(15-19)8-7-16-5-6-16/h1,3-4,9-12,15-16H,2,5-8,13-14H2,(H2,28,30)	HAEYOFDFQFNGQU-UHFFFAOYSA-N	50300722	8-(3-(2-cyclopropylethyl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL583888	Beta-secretase 2			 3780							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300722	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300722&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11647909	104155083		CHEMBL583888				ZINC35998158	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535894	COc1ccc(cc1)C1(N=C(N)N2CCCN=C12)c1cccc(c1)-c1cncnc1	InChI=1S/C23H22N6O/c1-30-20-8-6-18(7-9-20)23(21-27-10-3-11-29(21)22(24)28-23)19-5-2-4-16(12-19)17-13-25-15-26-14-17/h2,4-9,12-15H,3,10-11H2,1H3,(H2,24,28)	LSPPQVUEXNMTCS-UHFFFAOYSA-N	50300721	8-(4-methoxyphenyl)-8-(3-(pyrimidin-5-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL582828	Beta-secretase 2			 16180							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300721	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300721&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11711024	104155082		CHEMBL582828				ZINC34635822	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535895	NC1=NC(C2=NCCCN12)(c1ccccc1)c1cccc(Cc2ccc(F)cc2)c1	InChI=1S/C25H23FN4/c26-22-12-10-18(11-13-22)16-19-6-4-9-21(17-19)25(20-7-2-1-3-8-20)23-28-14-5-15-30(23)24(27)29-25/h1-4,6-13,17H,5,14-16H2,(H2,27,29)	HNKINZGWDMPNGM-UHFFFAOYSA-N	50300726	8-(3-(4-fluorobenzyl)phenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL567653	Beta-secretase 2			 7000							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300726	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300726&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11553053	104155087		CHEMBL567653				ZINC35794563	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535896	NC1=NC(C2=NCCCN12)(c1ccccc1)c1cccc(Cc2ccccc2)c1	InChI=1S/C25H24N4/c26-24-28-25(21-12-5-2-6-13-21,23-27-15-8-16-29(23)24)22-14-7-11-20(18-22)17-19-9-3-1-4-10-19/h1-7,9-14,18H,8,15-17H2,(H2,26,28)	ZIPALACJMVBMLD-UHFFFAOYSA-N	50300727	8-(3-benzylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL566977	Beta-secretase 2			 10900							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300727&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11710655	104155088		CHEMBL566977				ZINC34635398	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535897	COc1ccc(Cc2cccc(c2)C2(N=C(N)N3CCCN=C23)c2ccccc2)cc1	InChI=1S/C26H26N4O/c1-31-23-13-11-19(12-14-23)17-20-7-5-10-22(18-20)26(21-8-3-2-4-9-21)24-28-15-6-16-30(24)25(27)29-26/h2-5,7-14,18H,6,15-17H2,1H3,(H2,27,29)	ORUROHUFAQTTIX-UHFFFAOYSA-N	50300728	8-(3-(4-methoxybenzyl)phenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL568506	Beta-secretase 2			 22400							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300728&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11618427	104155089		CHEMBL568506				ZINC35943338	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535898	COc1cccc(c1)C1(N=C(N)N2CCCN=C12)c1ccccc1	InChI=1S/C19H20N4O/c1-24-16-10-5-9-15(13-16)19(14-7-3-2-4-8-14)17-21-11-6-12-23(17)18(20)22-19/h2-5,7-10,13H,6,11-12H2,1H3,(H2,20,22)	XIYBKNUQOILLJU-UHFFFAOYSA-N	50300729	8-(3-methoxyphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL565251	Beta-secretase 2			 24400							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300729	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300729&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11493476	104155090		CHEMBL565251				ZINC45245769	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535918	NC1=NC(C2=NCCCN12)(c1ccccc1)c1ccccc1	InChI=1S/C18H18N4/c19-17-21-18(14-8-3-1-4-9-14,15-10-5-2-6-11-15)16-20-12-7-13-22(16)17/h1-6,8-11H,7,12-13H2,(H2,19,21)	UFWSJOVQEPTPNE-UHFFFAOYSA-N	50300710	8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL582044	Beta-secretase 2			 38300							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	454	3IGB	11543843	104155071		CHEMBL582044				ZINC34657615	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535930	NC1=N[C@](C2=NCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cncnc1	InChI=1S/C23H19F3N6O/c24-23(25,26)33-19-7-5-17(6-8-19)22(20-30-9-2-10-32(20)21(27)31-22)18-4-1-3-15(11-18)16-12-28-14-29-13-16/h1,3-8,11-14H,2,9-10H2,(H2,27,31)/t22-/m1/s1	FYQZYBSHWLRFKL-JOCHJYFZSA-N	50300732	(8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL582045	Beta-secretase 2			 10700							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300732&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11539712	104155093		CHEMBL582045					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535932	NC1=N[C@](C2=NCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C24H19F4N5O/c25-20-19(6-2-11-30-20)15-4-1-5-17(14-15)23(21-31-12-3-13-33(21)22(29)32-23)16-7-9-18(10-8-16)34-24(26,27)28/h1-2,4-11,14H,3,12-13H2,(H2,29,32)/t23-/m1/s1	OPSMDCTXTURNQW-HSZRJFAPSA-N	50300733	(8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL576258	Beta-secretase 2			 3600							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300733&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11532880	104155094		CHEMBL576258				ZINC35998746	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535957	NC1=NC(C2=NOCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C23H17F4N5O2/c24-19-18(5-2-10-29-19)14-3-1-4-16(13-14)22(20-31-33-12-11-32(20)21(28)30-22)15-6-8-17(9-7-15)34-23(25,26)27/h1-10,13H,11-12H2,(H2,28,30)	SCODXNNXABJQIY-UHFFFAOYSA-N	50300711	8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-4,8-dihydro-3H-imidazo[5,1-c][1,2,4]oxadiazin-6-amine::CHEMBL567430	Beta-secretase 2			 2000							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300711	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300711&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			24950594	104155072		CHEMBL567430				ZINC45253858	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50535958	NC1=NC(C2=NCCCN12)(c1ccccc1)c1cccc(c1)C(F)(F)F	InChI=1S/C19H17F3N4/c20-19(21,22)15-9-4-8-14(12-15)18(13-6-2-1-3-7-13)16-24-10-5-11-26(16)17(23)25-18/h1-4,6-9,12H,5,10-11H2,(H2,23,25)	MVTVKWUNLOATLP-UHFFFAOYSA-N	50300731	8-phenyl-8-(3-(trifluoromethyl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL565250	Beta-secretase 2			 30100							ChEMBL	10.1021/jm9006752	10.7270/Q2Z89CHR	19757823			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Johnson, M; Hui, Y; Turner, J; Hu, Y; Wagner, E; Fan, K; Olland, A; Bard, J; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11544960	104155092		CHEMBL565250				ZINC34659645	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50878725	CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22N=C(C)C(N)=N2)-c2cncc(c2)C#CC)CC1	InChI=1S/C17H17FN4O2/c1-2-3-15-8-16(21-24-15)17(23)20-14-9-19-22(11-14)10-12-4-6-13(18)7-5-12/h4-9,11H,2-3,10H2,1H3,(H,20,23)	MJBZMUZAEXQVAB-UHFFFAOYSA-N	41542	US8865911, 122	Beta-secretase 2		 372								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41542	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41542&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			67979346	249815366						ZINC03909028	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50878726	NC1=N[C@@](c2cccc(F)c12)(c1cccc(c1)-c1cncnc1)c1ccnc(c1)C(F)F	InChI=1S/C24H16F3N5/c25-19-6-2-5-18-21(19)23(28)32-24(18,17-7-8-31-20(10-17)22(26)27)16-4-1-3-14(9-16)15-11-29-13-30-12-15/h1-13,22H,(H2,28,32)/t24-/m0/s1	MRXBCEQZNKUUIP-DEOSSOPVSA-N	50398264	CHEMBL2177913	Beta-secretase 2			 0.900000							ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	32D	4B05	46202416	163347288		CHEMBL2177913				ZINC68205977	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879212	CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@]22COC(N)=N2)-c2cc(Cl)cc(c2)C#N)CC1	InChI=1S/C24H24ClN3O2/c1-29-20-4-6-23(7-5-20)12-17-3-2-16(18-8-15(13-26)9-19(25)10-18)11-21(17)24(23)14-30-22(27)28-24/h2-3,8-11,20H,4-7,12,14H2,1H3,(H2,27,28)/t20-,23-,24-/m1/s1	FQJNFWHRRHDNQF-AGILITTLSA-N	50264190	CHEMBL4092875	Beta-secretase 2		 2193								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264190&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137653962	404341753							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879216	CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22COC(N)=N2)-c2cc(Cl)cc(c2)C#N)CC1	InChI=1S/C24H24ClN3O2/c1-29-20-4-6-23(7-5-20)12-17-3-2-16(18-8-15(13-26)9-19(25)10-18)11-21(17)24(23)14-30-22(27)28-24/h2-3,8-11,20H,4-7,12,14H2,1H3,(H2,27,28)/t20-,23-,24-/m0/s1	FQJNFWHRRHDNQF-OYDLWJJNSA-N	50264192	CHEMBL4072118	Beta-secretase 2		 21								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264192&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			132068809	404341754							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50569009	CCCCCOc1ccc(cc1)-c1ccc(-c2ccccc2Cl)n1Cc1ccc(NCCCO)c(N)n1	InChI=1S/C30H35ClN4O2/c1-2-3-6-20-37-24-13-10-22(11-14-24)28-16-17-29(25-8-4-5-9-26(25)31)35(28)21-23-12-15-27(30(32)34-23)33-18-7-19-36/h4-5,8-17,33,36H,2-3,6-7,18-21H2,1H3,(H2,32,34)	PBMMEMHFZBWZEJ-UHFFFAOYSA-N	50315008	3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-ylamino)propan-1-ol::CHEMBL1089204	Beta-secretase 2			 470							ChEMBL	10.1016/j.bmcl.2010.02.075	10.7270/Q2PG1RWS	20223661			Malamas, MS; Barnes, K; Hui, Y; Johnson, M; Lovering, F; Condon, J; Fobare, W; Solvibile, W; Turner, J; Hu, Y; Manas, ES; Fan, K; Olland, A; Chopra, R; Bard, J; Pangalos, MN; Reinhart, P; Robichaud, AJ	Wyeth	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315008&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11620576	104149369		CHEMBL1089204				ZINC49112114	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50569010	CCCCCOc1ccc(cc1)-c1ccc(-c2ccccc2Cl)n1Cc1ccc(NCCO)c(N)n1	InChI=1S/C29H33ClN4O2/c1-2-3-6-19-36-23-12-9-21(10-13-23)27-15-16-28(24-7-4-5-8-25(24)30)34(27)20-22-11-14-26(29(31)33-22)32-17-18-35/h4-5,7-16,32,35H,2-3,6,17-20H2,1H3,(H2,31,33)	JUOGTZUVNDFPCE-UHFFFAOYSA-N	50314995	2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-ylamino)ethanol::CHEMBL1089186	Beta-secretase 2			 1000							ChEMBL	10.1016/j.bmcl.2010.02.075	10.7270/Q2PG1RWS	20223661			Malamas, MS; Barnes, K; Hui, Y; Johnson, M; Lovering, F; Condon, J; Fobare, W; Solvibile, W; Turner, J; Hu, Y; Manas, ES; Fan, K; Olland, A; Chopra, R; Bard, J; Pangalos, MN; Reinhart, P; Robichaud, AJ	Wyeth	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314995&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11684817	104149356		CHEMBL1089186				ZINC38246362	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50569011	Nc1cccc(Cn2c(ccc2-c2ccccc2Cl)-c2ccc(OCCCC#N)cc2)n1	InChI=1S/C26H23ClN4O/c27-23-8-2-1-7-22(23)25-15-14-24(31(25)18-20-6-5-9-26(29)30-20)19-10-12-21(13-11-19)32-17-4-3-16-28/h1-2,5-15H,3-4,17-18H2,(H2,29,30)	CERJQPWNRISSQS-UHFFFAOYSA-N	50315004	4-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorophenyl)-1H-pyrrol-2-yl)phenoxy)butanenitrile::4-(4-{1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorophenyl)-1H-pyrrol-2-yl}phenoxy)butanenitrile::CHEMBL1089137	Beta-secretase 2			 7100							ChEMBL	10.1016/j.bmcl.2010.02.075	10.7270/Q2PG1RWS	20223661			Malamas, MS; Barnes, K; Hui, Y; Johnson, M; Lovering, F; Condon, J; Fobare, W; Solvibile, W; Turner, J; Hu, Y; Manas, ES; Fan, K; Olland, A; Chopra, R; Bard, J; Pangalos, MN; Reinhart, P; Robichaud, AJ	Wyeth	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315004&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	625	3L3A	11719190	104149365		CHEMBL1089137				ZINC34642784	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879217	CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22COC(N)=N2)-c2cc(OC)cc(c2)C#N)CC1	InChI=1S/C25H27N3O3/c1-29-20-5-7-24(8-6-20)13-18-4-3-17(12-22(18)25(24)15-31-23(27)28-25)19-9-16(14-26)10-21(11-19)30-2/h3-4,9-12,20H,5-8,13,15H2,1-2H3,(H2,27,28)/t20-,24-,25-/m0/s1	HGMWSDRCFLAMIZ-OPXMRZJTSA-N	50264193	CHEMBL4084381	Beta-secretase 2		 13								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264193&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137646113	404341755							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879233	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@@H](CC1)OC)-c1cc(OC)cc(c1)C#N	InChI=1S/C25H27N3O3/c1-29-20-5-7-24(8-6-20)13-18-4-3-17(12-22(18)25(24)15-31-23(27)28-25)19-9-16(14-26)10-21(11-19)30-2/h3-4,9-12,20H,5-8,13,15H2,1-2H3,(H2,27,28)/t20-,24-,25-/m0/s1/i15D2	HGMWSDRCFLAMIZ-INDJQTKRSA-N	50264154	CHEMBL4100832	Beta-secretase 2		 13								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264154&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137660988	104112252							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565941	CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC[C@@H](C1)[C@@H](NC(C)=O)C(C)C	InChI=1S/C30H49N3O4/c1-6-7-16-31-29(36)21(4)17-27(35)26(18-23-12-9-8-10-13-23)33-30(37)25-15-11-14-24(19-25)28(20(2)3)32-22(5)34/h8-10,12-13,20-21,24-28,35H,6-7,11,14-19H2,1-5H3,(H,31,36)(H,32,34)(H,33,37)/t21-,24+,25-,26+,27+,28+/m1/s1	YCKCGNOTIFRWCX-BLBYSKFESA-N	50313799	(1R,3S)-3-((S)-1-acetamido-2-methylpropyl)-N-((2S,3S,5R)-6-(butylamino)-3-hydroxy-5-methyl-6-oxo-1-phenylhexan-2-yl)cyclohexanecarboxamide::CHEMBL1092504	Beta-secretase 2			 170							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313799&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46217866	104148160		CHEMBL1092504				ZINC49781104	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565942	CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC[C@@H](C1)C(C)(C)NC(C)=O	InChI=1S/C29H47N3O4/c1-6-7-16-30-27(35)20(2)17-26(34)25(18-22-12-9-8-10-13-22)31-28(36)23-14-11-15-24(19-23)29(4,5)32-21(3)33/h8-10,12-13,20,23-26,34H,6-7,11,14-19H2,1-5H3,(H,30,35)(H,31,36)(H,32,33)/t20-,23-,24+,25+,26+/m1/s1	NGUMIHCAWWHVPZ-MTKOPPBXSA-N	50313800	(1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S,5R)-6-(butylamino)-3-hydroxy-5-methyl-6-oxo-1-phenylhexan-2-yl)cyclohexanecarboxamide::(1R,3S)-3-[1-(acetylamino)-1-methylethyl]-N-[(1S,2S,4R)-1-benzyl-5-(butylamino)-2-hydroxy-4-methyl-5-oxopentyl]cyclohexanecarboxamide::CHEMBL1093388	Beta-secretase 2			 370							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313800&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	AYH	3K5F	45259044	104148161		CHEMBL1093388				ZINC44460280	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565943	CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC[C@@H](C1)C1(CCCC1)NC(C)=O	InChI=1S/C31H49N3O4/c1-4-5-18-32-29(37)22(2)19-28(36)27(20-24-12-7-6-8-13-24)33-30(38)25-14-11-15-26(21-25)31(34-23(3)35)16-9-10-17-31/h6-8,12-13,22,25-28,36H,4-5,9-11,14-21H2,1-3H3,(H,32,37)(H,33,38)(H,34,35)/t22-,25-,26+,27+,28+/m1/s1	GHBPZWZTVLXXSE-RFSBGUOESA-N	50313801	(1R,3S)-3-(1-acetamidocyclopentyl)-N-((2S,3S,5R)-6-(butylamino)-3-hydroxy-5-methyl-6-oxo-1-phenylhexan-2-yl)cyclohexanecarboxamide::CHEMBL1084153	Beta-secretase 2			 1500							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313801&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46881646	104148162		CHEMBL1084153				ZINC49775710	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565945	CC(C)c1cccc(CNC[C@H](O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCC[C@@H](C2)C(C)(C)NC(C)=O)c1	InChI=1S/C32H47N3O3/c1-22(2)26-14-9-13-25(17-26)20-33-21-30(37)29(18-24-11-7-6-8-12-24)34-31(38)27-15-10-16-28(19-27)32(4,5)35-23(3)36/h6-9,11-14,17,22,27-30,33,37H,10,15-16,18-21H2,1-5H3,(H,34,38)(H,35,36)/t27-,28+,29+,30+/m1/s1	JKZUWZCUDKMAKA-RYTSNQFKSA-N	50313802	(1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzylamino)-1-phenylbutan-2-yl)cyclohexanecarboxamide::CHEMBL1084154	Beta-secretase 2			 3800							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313802&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46881691	104148163		CHEMBL1084154				ZINC49792976	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565946	CCC(=O)NC(C)(C)[C@H]1CCC[C@H](C1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CNCc1cccc(c1)C(C)C	InChI=1S/C33H49N3O3/c1-6-31(38)36-33(4,5)28-17-11-16-27(20-28)32(39)35-29(19-24-12-8-7-9-13-24)30(37)22-34-21-25-14-10-15-26(18-25)23(2)3/h7-10,12-15,18,23,27-30,34,37H,6,11,16-17,19-22H2,1-5H3,(H,35,39)(H,36,38)/t27-,28+,29+,30+/m1/s1	PCVULHPMCAPMCJ-RYTSNQFKSA-N	50313803	(1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzylamino)-1-phenylbutan-2-yl)-3-(2-propionamidopropan-2-yl)cyclohexanecarboxamide::CHEMBL1084432	Beta-secretase 2			 3700							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313803&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46881692	104148164		CHEMBL1084432				ZINC49777233	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565947	CCC(=O)N(C)C(C)(C)[C@H]1CCC[C@H](C1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CNCc1cccc(c1)C(C)C	InChI=1S/C34H51N3O3/c1-7-32(39)37(6)34(4,5)29-18-12-17-28(21-29)33(40)36-30(20-25-13-9-8-10-14-25)31(38)23-35-22-26-15-11-16-27(19-26)24(2)3/h8-11,13-16,19,24,28-31,35,38H,7,12,17-18,20-23H2,1-6H3,(H,36,40)/t28-,29+,30+,31+/m1/s1	LVGZIFOZGQDLRO-BHSUFKTOSA-N	50313804	(1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzylamino)-1-phenylbutan-2-yl)-3-(2-(N-methylpropionamido)propan-2-yl)cyclohexanecarboxamide::CHEMBL1077232	Beta-secretase 2			 200							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313804&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46844429	104148165		CHEMBL1077232				ZINC49792079	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565948	CC(C)c1cccc(CNC[C@H](O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCC[C@@H](C2)C(C)(C)N2CCCC2=O)c1	InChI=1S/C34H49N3O3/c1-24(2)27-14-8-13-26(19-27)22-35-23-31(38)30(20-25-11-6-5-7-12-25)36-33(40)28-15-9-16-29(21-28)34(3,4)37-18-10-17-32(37)39/h5-8,11-14,19,24,28-31,35,38H,9-10,15-18,20-23H2,1-4H3,(H,36,40)/t28-,29+,30+,31+/m1/s1	ZTFBNTHPVBDCAM-BHSUFKTOSA-N	50313805	(1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzylamino)-1-phenylbutan-2-yl)-3-(2-(2-oxopyrrolidin-1-yl)propan-2-yl)cyclohexanecarboxamide::CHEMBL1077236	Beta-secretase 2			 960							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313805&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46881693	104148166		CHEMBL1077236				ZINC49777692	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50565949	CC(C)c1cccc(CNC[C@H](O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCC[C@@H](C2)C(C)(C)N2CCCCC2=O)c1	InChI=1S/C35H51N3O3/c1-25(2)28-15-10-14-27(20-28)23-36-24-32(39)31(21-26-12-6-5-7-13-26)37-34(41)29-16-11-17-30(22-29)35(3,4)38-19-9-8-18-33(38)40/h5-7,10,12-15,20,25,29-32,36,39H,8-9,11,16-19,21-24H2,1-4H3,(H,37,41)/t29-,30+,31+,32+/m1/s1	MFPZDLDVZIAMTN-ZLESDFJESA-N	50313806	(1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzylamino)-1-phenylbutan-2-yl)-3-(2-(2-oxopiperidin-1-yl)propan-2-yl)cyclohexanecarboxamide::CHEMBL1077237	Beta-secretase 2			 140							ChEMBL	10.1016/j.bmcl.2010.01.139	10.7270/Q2TD9XHH	20172717			Hanessian, S; Shao, Z; Betschart, C; Rondeau, JM; Neumann, U; Tintelnot-Blomley, M	Universit&#163; de Montr&#163;al	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313806&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46844428	104148167		CHEMBL1077237				ZINC49777770	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567981	CN1C(N)=NC(C1=O)(c1ccccc1)c1ccncc1	InChI=1S/C15H14N4O/c1-19-13(20)15(18-14(19)16,11-5-3-2-4-6-11)12-7-9-17-10-8-12/h2-10H,1H3,(H2,16,18)	IMGNUVBMHZZYCN-UHFFFAOYSA-N	50310154	2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL597233::rac-2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 2010							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310154&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951413	104144515		CHEMBL597233				ZINC34806279	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567982	CN1C(N)=N[C@@](C1=O)(c1ccncc1)c1cccc(c1)-c1cc(F)ccc1F	InChI=1S/C21H16F2N4O/c1-27-19(28)21(26-20(27)24,14-7-9-25-10-8-14)15-4-2-3-13(11-15)17-12-16(22)5-6-18(17)23/h2-12H,1H3,(H2,24,26)/t21-/m0/s1	RKYFABJLGJZOBA-NRFANRHFSA-N	50314605	(R)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1093066	Beta-secretase 2			 700							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314605&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46883936	104148966		CHEMBL1093066					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567983	CN1C(N)=N[C@](C1=O)(c1ccncc1)c1cccc(c1)-c1cc(F)ccc1F	InChI=1S/C21H16F2N4O/c1-27-19(28)21(26-20(27)24,14-7-9-25-10-8-14)15-4-2-3-13(11-15)17-12-16(22)5-6-18(17)23/h2-12H,1H3,(H2,24,26)/t21-/m1/s1	RKYFABJLGJZOBA-OAQYLSRUSA-N	50314606	(5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-methyl-5-pyridin-4-yl-3,5-dihydro-4H-imidazol-4-one::(S)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1092788	Beta-secretase 2			 100							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314606	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314606&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	Z81	3LHG	46830239	104148967		CHEMBL1092788					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567984	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1ccccc1	InChI=1S/C21H18N4O/c1-25-19(26)21(24-20(25)22,17-10-12-23-13-11-17)18-9-5-8-16(14-18)15-6-3-2-4-7-15/h2-14H,1H3,(H2,22,24)	RDWGKVFCNRXSNW-UHFFFAOYSA-N	50310149	2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL598876::rac-2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 140							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310149&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951416	104144510		CHEMBL598876				ZINC34806291	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567985	COc1cccc(c1)-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccncc1	InChI=1S/C22H20N4O2/c1-26-20(27)22(25-21(26)23,17-9-11-24-12-10-17)18-7-3-5-15(13-18)16-6-4-8-19(14-16)28-2/h3-14H,1-2H3,(H2,23,25)	PVTVKIDYHUXCHW-UHFFFAOYSA-N	50314607	2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1092124	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314607&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951489	104148968		CHEMBL1092124				ZINC34806437	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567986	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccc(OC(F)(F)F)c1	InChI=1S/C22H17F3N4O2/c1-29-19(30)21(28-20(29)26,16-8-10-27-11-9-16)17-6-2-4-14(12-17)15-5-3-7-18(13-15)31-22(23,24)25/h2-13H,1H3,(H2,26,28)	JAKDICIOTSABEG-UHFFFAOYSA-N	50314608	2-amino-1-methyl-4-(pyridin-4-yl)-4-(3'-(trifluoromethoxy)biphenyl-3-yl)-1H-imidazol-5(4H)-one::CHEMBL1092125	Beta-secretase 2			 140							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314608&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951486	104148969		CHEMBL1092125				ZINC34806426	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567987	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccc(c1)C#N	InChI=1S/C22H17N5O/c1-27-20(28)22(26-21(27)24,18-8-10-25-11-9-18)19-7-3-6-17(13-19)16-5-2-4-15(12-16)14-23/h2-13H,1H3,(H2,24,26)	MADLMWLQBKXXTR-UHFFFAOYSA-N	50314609	3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-dihydro-1H-imidazol-4-yl)biphenyl-3-carbonitrile::CHEMBL1092475	Beta-secretase 2			 40							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314609&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951487	104148970		CHEMBL1092475				ZINC34806430	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567988	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccc(F)c1	InChI=1S/C21H17FN4O/c1-26-19(27)21(25-20(26)23,16-8-10-24-11-9-16)17-6-2-4-14(12-17)15-5-3-7-18(22)13-15/h2-13H,1H3,(H2,23,25)	BYOHYWAJTOLKKC-UHFFFAOYSA-N	50314610	2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1092476	Beta-secretase 2			 80							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314610&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951420	104148971		CHEMBL1092476				ZINC34806305	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567989	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccc(F)c1F	InChI=1S/C21H16F2N4O/c1-27-19(28)21(26-20(27)24,14-8-10-25-11-9-14)15-5-2-4-13(12-15)16-6-3-7-17(22)18(16)23/h2-12H,1H3,(H2,24,26)	GIDCLQLMYYYDAO-UHFFFAOYSA-N	50314611	2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1092786	Beta-secretase 2			 130							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314611&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46883935	104148972		CHEMBL1092786				ZINC49125784	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567990	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cc(F)cc(F)c1	InChI=1S/C21H16F2N4O/c1-27-19(28)21(26-20(27)24,15-5-7-25-8-6-15)16-4-2-3-13(9-16)14-10-17(22)12-18(23)11-14/h2-12H,1H3,(H2,24,26)	AYXHXAPMJNZSFH-UHFFFAOYSA-N	50314600	2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1091463	Beta-secretase 2			 60							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314600&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951484	104148961		CHEMBL1091463				ZINC34806420	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567991	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1ccsc1	InChI=1S/C19H16N4OS/c1-23-17(24)19(22-18(23)20,15-5-8-21-9-6-15)16-4-2-3-13(11-16)14-7-10-25-12-14/h2-12H,1H3,(H2,20,22)	LNJSOHPMNUFUKA-UHFFFAOYSA-N	50314601	2-amino-1-methyl-4-(pyridin-4-yl)-4-(3-(thiophen-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1091441	Beta-secretase 2			 190							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314601&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950518	104148962		CHEMBL1091441				ZINC34804564	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567992	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1ccoc1	InChI=1S/C19H16N4O2/c1-23-17(24)19(22-18(23)20,15-5-8-21-9-6-15)16-4-2-3-13(11-16)14-7-10-25-12-14/h2-12H,1H3,(H2,20,22)	TWFCSUNZDWGKTE-UHFFFAOYSA-N	50314602	2-amino-4-(3-(furan-3-yl)phenyl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1090025	Beta-secretase 2			 570							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314602&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950520	104148963		CHEMBL1090025				ZINC34804572	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567993	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cnccn1	InChI=1S/C19H16N6O/c1-25-17(26)19(24-18(25)20,14-5-7-21-8-6-14)15-4-2-3-13(11-15)16-12-22-9-10-23-16/h2-12H,1H3,(H2,20,24)	RXUACQZGEBHKBX-UHFFFAOYSA-N	50314612	2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1090026	Beta-secretase 2			 1010							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314612&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951488	104148973		CHEMBL1090026				ZINC34806434	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567994	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccnc1	InChI=1S/C20H17N5O/c1-25-18(26)20(24-19(25)21,16-7-10-22-11-8-16)17-6-2-4-14(12-17)15-5-3-9-23-13-15/h2-13H,1H3,(H2,21,24)	AIKOTXHNUIYVMD-UHFFFAOYSA-N	50310155	2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL604590::rac-2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 480							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310155&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	472	3IN3	15950666	104144516		CHEMBL604590				ZINC34804868	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567995	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C20H16FN5O/c1-26-18(27)20(25-19(26)22,14-7-10-23-11-8-14)15-5-2-4-13(12-15)16-6-3-9-24-17(16)21/h2-12H,1H3,(H2,22,25)	CMYIUDXGRYVNQW-UHFFFAOYSA-N	50314603	2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1090027	Beta-secretase 2			 1000							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314603&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46884002	104148964		CHEMBL1090027				ZINC49067891	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50567996	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cc(F)ccc1F	InChI=1S/C21H16F2N4O/c1-27-19(28)21(26-20(27)24,14-7-9-25-10-8-14)15-4-2-3-13(11-15)17-12-16(22)5-6-18(17)23/h2-12H,1H3,(H2,24,26)	RKYFABJLGJZOBA-UHFFFAOYSA-N	50314604	(+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1092787	Beta-secretase 2			 120							ChEMBL	10.1016/j.bmcl.2010.01.136	10.7270/Q28C9WDF	20202842			Zhou, P; Li, Y; Fan, Y; Wang, Z; Chopra, R; Olland, A; Hu, Y; Magolda, RL; Pangalos, M; Reinhart, PH; Turner, MJ; Bard, J; Malamas, MS; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314604&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	Z81	3LHG	11990754	104148965		CHEMBL1092787				ZINC49070017	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50574027	COC[C@H]1CCCN1C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1CN(CCN1)S(=O)(=O)c1cccc(C)c1	InChI=1S/C35H42F2N4O6S/c1-22-6-4-8-30(14-22)48(45,46)40-11-9-38-32(20-40)33(42)31(17-24-15-27(36)19-28(37)16-24)39-34(43)25-12-23(2)13-26(18-25)35(44)41-10-5-7-29(41)21-47-3/h4,6,8,12-16,18-19,29,31-33,38,42H,5,7,9-11,17,20-21H2,1-3H3,(H,39,43)/t29-,31+,32-,33+/m1/s1	CQQMWBPWYUPVOC-PPESYSCFSA-N	50317048	CHEMBL1097342::N-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R)-4-(m-tolylsulfonyl)piperazin-2-yl)propan-2-yl)-3-((R)-2-(methoxymethyl)pyrrolidine-1-carbonyl)-5-methylbenzamide::N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-{(2R)-4-[(3-methylphenyl)sulfonyl]piperazin-2-yl}ethyl]-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide	Beta-secretase 2		 5.4								ChEMBL	10.1016/j.bmcl.2010.03.050	10.7270/Q2BK1CH7	20347593			Cumming, J; Babu, S; Huang, Y; Carrol, C; Chen, X; Favreau, L; Greenlee, W; Guo, T; Kennedy, M; Kuvelkar, R; Le, T; Li, G; McHugh, N; Orth, P; Ozgur, L; Parker, E; Saionz, K; Stamford, A; Strickland, C; Tadesse, D; Voigt, J; Zhang, L; Zhang, Q	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317048&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	Z76	3LPK	45105274	104151409		CHEMBL1097342				ZINC49802648	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50592397	CC[C@@H](CC(=O)NCC1CCCCC1)n1c(N)nc2cc(Cl)ccc12	InChI=1S/C19H27ClN4O/c1-2-15(11-18(25)22-12-13-6-4-3-5-7-13)24-17-9-8-14(20)10-16(17)23-19(24)21/h8-10,13,15H,2-7,11-12H2,1H3,(H2,21,23)(H,22,25)/t15-/m0/s1	UKACQFCXAAAWAE-HNNXBMFYSA-N	50324922	(3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(cyclohexylmethyl)pentanamide::(S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(cyclohexylmethyl)pentanamide::CHEMBL1222240	Beta-secretase 2			 8000							ChEMBL	10.1016/j.bmcl.2010.06.089	10.7270/Q2VQ32W7	20656487			Madden, J; Dod, JR; Godemann, R; Kraemer, J; Smith, M; Biniszkiewicz, M; Hallett, DJ; Barker, J; Dyekjaer, JD; Hesterkamp, T	Evotec UK Ltd	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324922&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	EV5	3MSL	46238536	117646243		CHEMBL1222240				ZINC58583410	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605477	CN1C(N)=N[C@@](C1=O)(c1ccccc1)c1ccc(OC(F)F)c(C)c1	InChI=1S/C18H17F2N3O2/c1-11-10-13(8-9-14(11)25-16(19)20)18(12-6-4-3-5-7-12)15(24)23(2)17(21)22-18/h3-10,16H,1-2H3,(H2,21,22)/t18-/m0/s1	DIBLNVRMNVPDAB-SFHVURJKSA-N	50329516	(S)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL1270431	Beta-secretase 2			 850							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329516	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329516&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25070195	123108631		CHEMBL1270431				ZINC64528013	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605552	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H17F3N4O2/c1-29-19(30)22(28-21(29)26,14-7-9-16(10-8-14)31-20(24)25)15-5-2-4-13(12-15)17-6-3-11-27-18(17)23/h2-12,20H,1H3,(H2,26,28)/t22-/m1/s1	OMAQNCHXLTWMDV-JOCHJYFZSA-N	50329517	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271244	Beta-secretase 2			 500							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329517	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329517&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52942108	123108632		CHEMBL1271244				ZINC64503977	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605553	CN1C(N)=N[C@@](C1=O)(c1ccccc1)c1ccc(OC(F)F)cc1	InChI=1S/C17H15F2N3O2/c1-22-14(23)17(21-16(22)20,11-5-3-2-4-6-11)12-7-9-13(10-8-12)24-15(18)19/h2-10,15H,1H3,(H2,20,21)/t17-/m0/s1	KODRKDOVQWYORQ-KRWDZBQOSA-N	50329518	(S)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL1271343	Beta-secretase 2			 1300							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329518	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329518&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16113753	123108633		CHEMBL1271343				ZINC35262243	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605554	COc1ccc(cc1)[C@@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H19FN4O2/c1-27-20(28)22(26-21(27)24,15-8-10-17(29-2)11-9-15)16-6-3-5-14(13-16)18-7-4-12-25-19(18)23/h3-13H,1-2H3,(H2,24,26)/t22-/m1/s1	RIWZSRFUUJMOEH-JOCHJYFZSA-N	50329519	(R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxyphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271344	Beta-secretase 2			 120							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329519	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329519&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52940827	123108634		CHEMBL1271344				ZINC64512885	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605555	CN1C(N)=N[C@](C1=O)(c1ccc(OCCF)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C23H20F2N4O2/c1-29-21(30)23(28-22(29)26,16-7-9-18(10-8-16)31-13-11-24)17-5-2-4-15(14-17)19-6-3-12-27-20(19)25/h2-10,12,14H,11,13H2,1H3,(H2,26,28)/t23-/m1/s1	IWNLEEUFYZWVMW-HSZRJFAPSA-N	50329520	(R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271450	Beta-secretase 2			 2830							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329520	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329520&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52946966	123108635		CHEMBL1271450				ZINC64514102	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605556	CN1C(N)=N[C@@](C1=O)(c1ccccc1)c1ccc(OC(F)(F)F)cc1	InChI=1S/C17H14F3N3O2/c1-23-14(24)16(22-15(23)21,11-5-3-2-4-6-11)12-7-9-13(10-8-12)25-17(18,19)20/h2-10H,1H3,(H2,21,22)/t16-/m0/s1	TVFYWSHHVQUWML-INIZCTEOSA-N	50329521	(S)-2-amino-1-methyl-4-phenyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1271451	Beta-secretase 2			 2680							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329521	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329521&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52940915	123108636		CHEMBL1271451				ZINC64514105	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605557	CN1C(N)=N[C@@](C1=O)(c1ccccc1)c1ccc(OCCF)cc1	InChI=1S/C18H18FN3O2/c1-22-16(23)18(21-17(22)20,13-5-3-2-4-6-13)14-7-9-15(10-8-14)24-12-11-19/h2-10H,11-12H2,1H3,(H2,20,21)/t18-/m0/s1	WKKSAUFKGYEBTL-SFHVURJKSA-N	50329522	(S)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one::CHEMBL1269918	Beta-secretase 2			 11700							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329522	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329522&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52942291	123108637		CHEMBL1269918				ZINC64527824	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605558	CC#Cc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1	InChI=1S/C20H17F2N3O2/c1-3-5-13-6-4-7-15(12-13)20(17(26)25(2)19(23)24-20)14-8-10-16(11-9-14)27-18(21)22/h4,6-12,18H,1-2H3,(H2,23,24)/t20-/m1/s1	RIIMHERUTFJZHJ-HXUWFJFHSA-N	50329543	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(prop-1-ynyl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1270934	Beta-secretase 2			 210							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329543	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329543&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52942848	123108658		CHEMBL1270934				ZINC64512071	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605559	CCCC#Cc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1	InChI=1S/C22H21F2N3O2/c1-3-4-5-7-15-8-6-9-17(14-15)22(19(28)27(2)21(25)26-22)16-10-12-18(13-11-16)29-20(23)24/h6,8-14,20H,3-4H2,1-2H3,(H2,25,26)/t22-/m1/s1	GRSRJXGZMHCKBH-JOCHJYFZSA-N	50329545	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(pent-1-ynyl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1271036	Beta-secretase 2			 350							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329545	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329545&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52940810	123108660		CHEMBL1271036				ZINC64528067	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605560	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1cccc(c1)C#CCCCCF	InChI=1S/C23H22F3N3O2/c1-29-20(30)23(28-22(29)27,17-10-12-19(13-11-17)31-21(25)26)18-9-6-8-16(15-18)7-4-2-3-5-14-24/h6,8-13,15,21H,2-3,5,14H2,1H3,(H2,27,28)/t23-/m1/s1	GABMJOBOOPAAAJ-HSZRJFAPSA-N	50329548	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-fluorohex-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271142	Beta-secretase 2			 320							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329548	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329548&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52948154	123108663		CHEMBL1271142				ZINC64527853	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605561	CC(C)C#Cc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1	InChI=1S/C22H21F2N3O2/c1-14(2)7-8-15-5-4-6-17(13-15)22(19(28)27(3)21(25)26-22)16-9-11-18(12-10-16)29-20(23)24/h4-6,9-14,20H,1-3H3,(H2,25,26)/t22-/m1/s1	UPNDWOIUFRVACM-JOCHJYFZSA-N	50329549	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(3-methylbut-1-ynyl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1271245	Beta-secretase 2			 40							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329549	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329549&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52950127	123108664		CHEMBL1271245				ZINC64503979	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605562	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1cccc(c1)C#CC1CC1	InChI=1S/C22H19F2N3O2/c1-27-19(28)22(26-21(27)25,16-9-11-18(12-10-16)29-20(23)24)17-4-2-3-15(13-17)8-7-14-5-6-14/h2-4,9-14,20H,5-6H2,1H3,(H2,25,26)/t22-/m1/s1	WQGSTVFPWRFZTI-JOCHJYFZSA-N	50329550	(R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271246	Beta-secretase 2			 70							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329550&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25127621	123108665		CHEMBL1271246				ZINC64503982	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605563	COCC#Cc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1	InChI=1S/C21H19F2N3O3/c1-26-18(27)21(25-20(26)24,15-8-10-17(11-9-15)29-19(22)23)16-7-3-5-14(13-16)6-4-12-28-2/h3,5,7-11,13,19H,12H2,1-2H3,(H2,24,25)/t21-/m1/s1	IXGXVDWUAASEAH-OAQYLSRUSA-N	50329552	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-methoxyprop-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271346	Beta-secretase 2			 140							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329552&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52944421	123108667		CHEMBL1271346				ZINC64512890	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605564	COCCC#Cc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1	InChI=1S/C22H21F2N3O3/c1-27-19(28)22(26-21(27)25,16-9-11-18(12-10-16)30-20(23)24)17-8-5-7-15(14-17)6-3-4-13-29-2/h5,7-12,14,20H,4,13H2,1-2H3,(H2,25,26)/t22-/m1/s1	TZGLGDNNNMVJMI-JOCHJYFZSA-N	50329553	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-methoxybut-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271452	Beta-secretase 2			 100							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329553&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52948174	123108668		CHEMBL1271452				ZINC64514106	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605565	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1ccc(F)c(OCCCF)c1	InChI=1S/C20H19F4N3O3/c1-27-17(28)20(26-19(27)25,12-3-6-14(7-4-12)30-18(23)24)13-5-8-15(22)16(11-13)29-10-2-9-21/h3-8,11,18H,2,9-10H2,1H3,(H2,25,26)/t20-/m1/s1	ZPKMNSUSQSIWHS-HXUWFJFHSA-N	50329558	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(3-fluoropropoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270029	Beta-secretase 2			 280							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329558	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329558&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			16113206	123108673		CHEMBL1270029				ZINC35261802	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605566	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1ccc(F)c(OCC(F)F)c1	InChI=1S/C19H16F5N3O3/c1-27-16(28)19(26-18(27)25,10-2-5-12(6-3-10)30-17(23)24)11-4-7-13(20)14(8-11)29-9-15(21)22/h2-8,15,17H,9H2,1H3,(H2,25,26)/t19-/m1/s1	KIAGCWNNPCJGFV-LJQANCHMSA-N	50329564	(R)-2-amino-4-(3-(2,2-difluoroethoxy)-4-fluorophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270339	Beta-secretase 2			 730							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329564&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52946545	123108679		CHEMBL1270339				ZINC35261808	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605567	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1ccc(F)c(c1)C#CC1CC1	InChI=1S/C22H18F3N3O2/c1-28-19(29)22(27-21(28)26,15-6-9-17(10-7-15)30-20(24)25)16-8-11-18(23)14(12-16)5-4-13-2-3-13/h6-13,20H,2-3H2,1H3,(H2,26,27)/t22-/m1/s1	JZQHTDKITQYMAR-JOCHJYFZSA-N	50329569	(R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270335	Beta-secretase 2			 120							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329569&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25127622	123108684		CHEMBL1270335				ZINC64512024	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605568	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)c(C)c1)c1ccc(F)c(c1)C#CC1CC1	InChI=1S/C23H20F3N3O2/c1-13-11-16(8-10-19(13)31-21(25)26)23(20(30)29(2)22(27)28-23)17-7-9-18(24)15(12-17)6-5-14-3-4-14/h7-12,14,21H,3-4H2,1-2H3,(H2,27,28)/t23-/m1/s1	JWLSQAAJQTZDQT-HSZRJFAPSA-N	50329570	(R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophenyl)-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270432	Beta-secretase 2			 160							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329570&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25070193	123108685		CHEMBL1270432				ZINC64528014	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605569	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)c(C)c1)c1ccc(F)c(OCC(F)F)c1	InChI=1S/C20H18F5N3O3/c1-10-7-11(4-6-14(10)31-18(24)25)20(17(29)28(2)19(26)27-20)12-3-5-13(21)15(8-12)30-9-16(22)23/h3-8,16,18H,9H2,1-2H3,(H2,26,27)/t20-/m1/s1	WADUKYMEQUUKLV-HXUWFJFHSA-N	50329572	(R)-2-amino-4-(3-(2,2-difluoroethoxy)-4-fluorophenyl)-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270530	Beta-secretase 2			 370							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329572&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25069561	123108687		CHEMBL1270530				ZINC43204080	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605570	CN1C(N)=N[C@@](C1=O)(c1cccc(c1)C#CC1CC1)c1ccc(OC(F)F)c(C)c1	InChI=1S/C23H21F2N3O2/c1-14-12-18(10-11-19(14)30-21(24)25)23(20(29)28(2)22(26)27-23)17-5-3-4-16(13-17)9-8-15-6-7-15/h3-5,10-13,15,21H,6-7H2,1-2H3,(H2,26,27)/t23-/m0/s1	PWZLUGHNDYWEDU-QHCPKHFHSA-N	50329573	(S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270630	Beta-secretase 2			 50							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329573&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25072736	123108688		CHEMBL1270630				ZINC64526665	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605571	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)c(C)c1)c1ccc(F)c(c1)C#CCF	InChI=1S/C21H17F4N3O2/c1-12-10-14(6-8-17(12)30-19(24)25)21(18(29)28(2)20(26)27-21)15-5-7-16(23)13(11-15)4-3-9-22/h5-8,10-11,19H,9H2,1-2H3,(H2,26,27)/t21-/m1/s1	JSGHRZJQFUOCAI-OAQYLSRUSA-N	50329574	(R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)-4-(4-fluoro-3-(3-fluoroprop-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270631	Beta-secretase 2			 170							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329574	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329574&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52949466	123108689		CHEMBL1270631				ZINC64526949	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605572	CCCC#Cc1cc(ccc1F)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)c(C)c1	InChI=1S/C23H22F3N3O2/c1-4-5-6-7-15-13-17(8-10-18(15)24)23(20(30)29(3)22(27)28-23)16-9-11-19(14(2)12-16)31-21(25)26/h8-13,21H,4-5H2,1-3H3,(H2,27,28)/t23-/m1/s1	GASOVDDSXLJYME-HSZRJFAPSA-N	50329575	(R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)-4-(4-fluoro-3-(pent-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270834	Beta-secretase 2			 110							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329575&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25073049	123108690		CHEMBL1270834				ZINC64513070	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605573	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1ccc(F)c(c1)C#CCCCF	InChI=1S/C22H19F4N3O2/c1-29-19(30)22(28-21(29)27,15-6-9-17(10-7-15)31-20(25)26)16-8-11-18(24)14(13-16)5-3-2-4-12-23/h6-11,13,20H,2,4,12H2,1H3,(H2,27,28)/t22-/m1/s1	ZSIZOKHLIKKQIV-JOCHJYFZSA-N	50329576	(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(5-fluoropent-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270835	Beta-secretase 2			 400							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329576	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329576&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	ZOO	3OOZ	52948140	123108691		CHEMBL1270835				ZINC64512404	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50605651	CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H16F4N4O2/c1-30-19(31)21(29-20(30)27,14-7-9-16(10-8-14)32-22(24,25)26)15-5-2-4-13(12-15)17-6-3-11-28-18(17)23/h2-12H,1H3,(H2,27,29)/t21-/m1/s1	JFVCKHOQNLFVNL-OAQYLSRUSA-N	50329515	(R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL1271140	Beta-secretase 2			 2480							ChEMBL	10.1016/j.bmcl.2010.09.029	10.7270/Q2C829JF	20880704			Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329515	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329515&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			52946950	123108630		CHEMBL1271140				ZINC45246009	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660228	CN1C(N)=NC(C1=O)(c1ccsc1)c1cccc(c1)-c1cnccn1	InChI=1S/C18H15N5OS/c1-23-16(24)18(22-17(23)19,14-5-8-25-11-14)13-4-2-3-12(9-13)15-10-20-6-7-21-15/h2-11H,1H3,(H2,19,22)	NXXHXFSKVSTXAG-UHFFFAOYSA-N	50352848	CHEMBL1824359	Beta-secretase 2			 440							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352848	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352848&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56675695	136359534		CHEMBL1824359				ZINC72179416	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660233	CCC(=O)c1cc(cs1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H19FN4O2S/c1-3-17(28)18-11-15(12-30-18)22(20(29)27(2)21(24)26-22)14-7-4-6-13(10-14)16-8-5-9-25-19(16)23/h4-12H,3H2,1-2H3,(H2,24,26)	SYHWIMVHWVXBDN-UHFFFAOYSA-N	50352849	CHEMBL1824360	Beta-secretase 2			 70							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352849&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56675696	136359535		CHEMBL1824360				ZINC72183355	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660237	CCn1cc(cn1)[C@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C20H19FN6O/c1-3-27-12-15(11-24-27)20(18(28)26(2)19(22)25-20)14-7-4-6-13(10-14)16-8-5-9-23-17(16)21/h4-12H,3H2,1-2H3,(H2,22,25)/t20-/m1/s1	IKJXVRPWMOVIMY-HXUWFJFHSA-N	50352850	CHEMBL1824335	Beta-secretase 2			 7390							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352850	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352850&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56668818	136359536		CHEMBL1824335				ZINC72182337	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660238	CCC(=O)c1cc(cs1)[C@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H19FN4O2S/c1-3-17(28)18-11-15(12-30-18)22(20(29)27(2)21(24)26-22)14-7-4-6-13(10-14)16-8-5-9-25-19(16)23/h4-12H,3H2,1-2H3,(H2,24,26)/t22-/m1/s1	SYHWIMVHWVXBDN-JOCHJYFZSA-N	50352851	CHEMBL1824362	Beta-secretase 2			 5450							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352851	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352851&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56682314	136359537		CHEMBL1824362					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660241	CCn1cc(cn1)[C@@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C20H19FN6O/c1-3-27-12-15(11-24-27)20(18(28)26(2)19(22)25-20)14-7-4-6-13(10-14)16-8-5-9-23-17(16)21/h4-12H,3H2,1-2H3,(H2,22,25)/t20-/m0/s1	IKJXVRPWMOVIMY-FQEVSTJZSA-N	50352852	CHEMBL1824145	Beta-secretase 2			 210							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352852	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352852&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56675689	136359538		CHEMBL1824145				ZINC72182338	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660246	CN1C(N)=N[C@](C1=O)(c1cnn(CC(F)(F)F)c1)c1cccc(c1)-c1cccnc1F	InChI=1S/C20H16F4N6O/c1-29-17(31)20(28-18(29)25,14-9-27-30(10-14)11-19(22,23)24)13-5-2-4-12(8-13)15-6-3-7-26-16(15)21/h2-10H,11H2,1H3,(H2,25,28)/t20-/m0/s1	FLYFOUIVIYZLRH-FQEVSTJZSA-N	50352853	CHEMBL1824338	Beta-secretase 2			 500							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352853	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352853&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56661917	136359539		CHEMBL1824338				ZINC72182869	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660250	CCC(=O)c1cc(cs1)[C@@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H19FN4O2S/c1-3-17(28)18-11-15(12-30-18)22(20(29)27(2)21(24)26-22)14-7-4-6-13(10-14)16-8-5-9-25-19(16)23/h4-12H,3H2,1-2H3,(H2,24,26)/t22-/m0/s1	SYHWIMVHWVXBDN-QFIPXVFZSA-N	50352854	CHEMBL1824361	Beta-secretase 2			 50							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352854&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56668821	136359540		CHEMBL1824361					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660251	NC1=NC(C2=NCCCN12)(c1ccccc1)c1ccccc1	InChI=1S/C18H18N4/c19-17-21-18(14-8-3-1-4-9-14,15-10-5-2-6-11-15)16-20-12-7-13-22(16)17/h1-6,8-11H,7,12-13H2,(H2,19,21)	UFWSJOVQEPTPNE-UHFFFAOYSA-N	50300710	8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL582044	Beta-secretase 2			 38300							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	454	3IGB	11543843	104155071		CHEMBL582044				ZINC34657615	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660255	CN1C(N)=NC(C1=O)(c1cnn(C)c1)c1cccc(c1)-c1cncnc1	InChI=1S/C18H17N7O/c1-24-10-15(9-22-24)18(16(26)25(2)17(19)23-18)14-5-3-4-12(6-14)13-7-20-11-21-8-13/h3-11H,1-2H3,(H2,19,23)	CORGHEXKCNZSJU-UHFFFAOYSA-N	50352855	CHEMBL1824133	Beta-secretase 2			 860							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352855&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56679262	136359541		CHEMBL1824133				ZINC72181806	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660259	CCn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C19H19N7O/c1-3-26-11-16(10-23-26)19(17(27)25(2)18(20)24-19)15-6-4-5-13(7-15)14-8-21-12-22-9-14/h4-12H,3H2,1-2H3,(H2,20,24)	DNDFMOOQRXKYQL-UHFFFAOYSA-N	50352856	CHEMBL1824134	Beta-secretase 2			 1470							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352856&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	591	3S7L	56682567	136359542		CHEMBL1824134				ZINC72181808	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660264	CCn1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cncnc1	InChI=1S/C19H18FN7O/c1-3-27-10-14(9-24-27)19(17(28)26(2)18(21)25-19)13-4-5-16(20)15(6-13)12-7-22-11-23-8-12/h4-11H,3H2,1-2H3,(H2,21,25)	QFKPRVADZPYBNW-UHFFFAOYSA-N	50352857	CHEMBL1824135	Beta-secretase 2			 2370							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352857&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11990755	136359543		CHEMBL1824135				ZINC72181810	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660268	CN1C(N)=NC(C1=O)(c1cnn(CC(F)(F)F)c1)c1ccc(F)c(c1)-c1cncnc1	InChI=1S/C19H15F4N7O/c1-29-16(31)19(28-17(29)24,13-7-27-30(8-13)9-18(21,22)23)12-2-3-15(20)14(4-12)11-5-25-10-26-6-11/h2-8,10H,9H2,1H3,(H2,24,28)	FCWFCMGXLUBIQD-UHFFFAOYSA-N	50352858	CHEMBL1824136	Beta-secretase 2			 8790							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352858	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352858&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950085	136359544		CHEMBL1824136				ZINC34803601	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660272	CC(C)n1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cncnc1	InChI=1S/C20H20FN7O/c1-12(2)28-10-15(9-25-28)20(18(29)27(3)19(22)26-20)14-4-5-17(21)16(6-14)13-7-23-11-24-8-13/h4-12H,1-3H3,(H2,22,26)	VGIXLLYAMZATOQ-UHFFFAOYSA-N	50352859	CHEMBL1824137	Beta-secretase 2			 6650							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352859&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56669107	136359545		CHEMBL1824137				ZINC72183224	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660275	CC(C)Cn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C21H23N7O/c1-14(2)11-28-12-18(10-25-28)21(19(29)27(3)20(22)26-21)17-6-4-5-15(7-17)16-8-23-13-24-9-16/h4-10,12-14H,11H2,1-3H3,(H2,22,26)	GJCACXYIYRCVKX-UHFFFAOYSA-N	50352860	CHEMBL1824138	Beta-secretase 2			 130							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352860&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950005	136359546		CHEMBL1824138				ZINC34803422	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660278	CC(C)CCn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C22H25N7O/c1-15(2)7-8-29-13-19(12-26-29)22(20(30)28(3)21(23)27-22)18-6-4-5-16(9-18)17-10-24-14-25-11-17/h4-6,9-15H,7-8H2,1-3H3,(H2,23,27)	DUYKHVPWTFUMKA-UHFFFAOYSA-N	50352861	CHEMBL1824139	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352861&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56658717	136359547		CHEMBL1824139				ZINC72179237	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660283	CN1C(N)=NC(C1=O)(c1cnn(CCC(C)(C)C)c1)c1cccc(c1)-c1cncnc1	InChI=1S/C23H27N7O/c1-22(2,3)8-9-30-14-19(13-27-30)23(20(31)29(4)21(24)28-23)18-7-5-6-16(10-18)17-11-25-15-26-12-17/h5-7,10-15H,8-9H2,1-4H3,(H2,24,28)	AMYWYRFRJYJRAM-UHFFFAOYSA-N	50352862	CHEMBL1824140	Beta-secretase 2			 30							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352862&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56658718	136359548		CHEMBL1824140				ZINC72183226	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660287	CCCCn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C21H23N7O/c1-3-4-8-28-13-18(12-25-28)21(19(29)27(2)20(22)26-21)17-7-5-6-15(9-17)16-10-23-14-24-11-16/h5-7,9-14H,3-4,8H2,1-2H3,(H2,22,26)	CRGYAUNBGVFARQ-UHFFFAOYSA-N	50352863	CHEMBL1824141	Beta-secretase 2			 150							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352863&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950006	136359549		CHEMBL1824141				ZINC34803427	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660291	CN1C(N)=NC(C1=O)(c1cnn(c1)C1CCCC1)c1cccc(c1)-c1cncnc1	InChI=1S/C22H23N7O/c1-28-20(30)22(27-21(28)23,18-12-26-29(13-18)19-7-2-3-8-19)17-6-4-5-15(9-17)16-10-24-14-25-11-16/h4-6,9-14,19H,2-3,7-8H2,1H3,(H2,23,27)	RSBLHFREHLCSDX-UHFFFAOYSA-N	50352864	CHEMBL1824142	Beta-secretase 2			 170							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352864&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56672294	136359550		CHEMBL1824142				ZINC72181010	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660295	CN1C(N)=NC(C1=O)(c1cnn(CCC2CCCCC2)c1)c1cccc(c1)-c1cncnc1	InChI=1S/C25H29N7O/c1-31-23(33)25(30-24(31)26,21-9-5-8-19(12-21)20-13-27-17-28-14-20)22-15-29-32(16-22)11-10-18-6-3-2-4-7-18/h5,8-9,12-18H,2-4,6-7,10-11H2,1H3,(H2,26,30)	IMPSJODCGOEHNO-UHFFFAOYSA-N	50352865	CHEMBL1824143	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352865&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56682312	136359551		CHEMBL1824143				ZINC72180463	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660304	CN1C(N)=NC(C1=O)(c1ccsc1)c1ccc(F)c(c1)-c1cccnc1F	InChI=1S/C19H14F2N4OS/c1-25-17(26)19(24-18(25)22,12-6-8-27-10-12)11-4-5-15(20)14(9-11)13-3-2-7-23-16(13)21/h2-10H,1H3,(H2,22,24)	JCEVTYZGXQGFEM-UHFFFAOYSA-N	50352867	CHEMBL1824357	Beta-secretase 2			 410							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352867&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56672299	136359553		CHEMBL1824357				ZINC72183186	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660306	COc1cncc(c1)-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccsc1	InChI=1S/C20H18N4O2S/c1-24-18(25)20(23-19(24)21,16-6-7-27-12-16)15-5-3-4-13(8-15)14-9-17(26-2)11-22-10-14/h3-12H,1-2H3,(H2,21,23)	PDTDVARFGYKUMS-UHFFFAOYSA-N	50352847	CHEMBL1824358	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352847	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352847&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56672300	136359533		CHEMBL1824358				ZINC72177496	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660311	CCn1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F	InChI=1S/C20H18F2N6O/c1-3-28-11-13(10-25-28)20(18(29)27(2)19(23)26-20)12-6-7-16(21)15(9-12)14-5-4-8-24-17(14)22/h4-11H,3H2,1-2H3,(H2,23,26)	XLKFXPAKZSTNHX-UHFFFAOYSA-N	50352868	CHEMBL1824336	Beta-secretase 2			 870							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352868&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950086	136359554		CHEMBL1824336				ZINC34803609	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660318	CC(C)n1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F	InChI=1S/C21H20F2N6O/c1-12(2)29-11-14(10-26-29)21(19(30)28(3)20(24)27-21)13-6-7-17(22)16(9-13)15-5-4-8-25-18(15)23/h4-12H,1-3H3,(H2,24,27)	HNEPKJNWZLGKMM-UHFFFAOYSA-N	50352870	CHEMBL1824339	Beta-secretase 2			 3120							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352870&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56672297	136359556		CHEMBL1824339				ZINC72183016	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660321	CC(C)Cn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H23FN6O/c1-14(2)12-29-13-17(11-26-29)22(20(30)28(3)21(24)27-22)16-7-4-6-15(10-16)18-8-5-9-25-19(18)23/h4-11,13-14H,12H2,1-3H3,(H2,24,27)	FCODAEYPNNQDQH-UHFFFAOYSA-N	50352871	CHEMBL1824340	Beta-secretase 2			 50							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352871&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950003	136359557		CHEMBL1824340				ZINC34803413	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660325	CC(C)CCn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C23H25FN6O/c1-15(2)9-11-30-14-18(13-27-30)23(21(31)29(3)22(25)28-23)17-7-4-6-16(12-17)19-8-5-10-26-20(19)24/h4-8,10,12-15H,9,11H2,1-3H3,(H2,25,28)	KBZBWMIJRAOKSO-UHFFFAOYSA-N	50352872	CHEMBL1824341	Beta-secretase 2			 18							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352872&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56678998	136359558		CHEMBL1824341				ZINC72182877	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660329	CN1C(N)=NC(C1=O)(c1cnn(CCC(C)(C)C)c1)c1cccc(c1)-c1cccnc1F	InChI=1S/C24H27FN6O/c1-23(2,3)10-12-31-15-18(14-28-31)24(21(32)30(4)22(26)29-24)17-8-5-7-16(13-17)19-9-6-11-27-20(19)25/h5-9,11,13-15H,10,12H2,1-4H3,(H2,26,29)	PKUREZXQXDANPA-UHFFFAOYSA-N	50352873	CHEMBL1824342	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352873&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56658435	136359559		CHEMBL1824342				ZINC72182879	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660332	CCC(CC)Cn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C24H27FN6O/c1-4-16(5-2)14-31-15-19(13-28-31)24(22(32)30(3)23(26)29-24)18-9-6-8-17(12-18)20-10-7-11-27-21(20)25/h6-13,15-16H,4-5,14H2,1-3H3,(H2,26,29)	YZUUNTCUAMHFQT-UHFFFAOYSA-N	50352874	CHEMBL1824343	Beta-secretase 2			 36							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352874&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56668819	136359560		CHEMBL1824343				ZINC72182745	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660336	CCCCn1cc(cn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C22H23FN6O/c1-3-4-11-29-14-17(13-26-29)22(20(30)28(2)21(24)27-22)16-8-5-7-15(12-16)18-9-6-10-25-19(18)23/h5-10,12-14H,3-4,11H2,1-2H3,(H2,24,27)	FSNVWNQXKNFHPF-UHFFFAOYSA-N	50352875	CHEMBL1824344	Beta-secretase 2			 50							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352875&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950004	136359561		CHEMBL1824344				ZINC34803417	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660340	CN1C(N)=NC(C1=O)(c1cnn(c1)C1CCCC1)c1cccc(c1)-c1cccnc1F	InChI=1S/C23H23FN6O/c1-29-21(31)23(28-22(29)25,17-13-27-30(14-17)18-8-2-3-9-18)16-7-4-6-15(12-16)19-10-5-11-26-20(19)24/h4-7,10-14,18H,2-3,8-9H2,1H3,(H2,25,28)	APLGTNIWHISFNN-UHFFFAOYSA-N	50352876	CHEMBL1824345	Beta-secretase 2			 120							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352876&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56665390	136359562		CHEMBL1824345				ZINC72183163	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660345	CN1C(N)=NC(C1=O)(c1ccsc1)c1cccc(c1)-c1cncnc1	InChI=1S/C18H15N5OS/c1-23-16(24)18(22-17(23)19,15-5-6-25-10-15)14-4-2-3-12(7-14)13-8-20-11-21-9-13/h2-11H,1H3,(H2,19,22)	GCIHPVGAAJVLEF-UHFFFAOYSA-N	50352877	CHEMBL1824346	Beta-secretase 2			 680							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56658436	136359563		CHEMBL1824346				ZINC72177500	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660348	CN1C(N)=NC(C1=O)(c1csc(C)c1)c1cccc(c1)-c1cncnc1	InChI=1S/C19H17N5OS/c1-12-6-16(10-26-12)19(17(25)24(2)18(20)23-19)15-5-3-4-13(7-15)14-8-21-11-22-9-14/h3-11H,1-2H3,(H2,20,23)	UDYLXYFIJLPZAV-UHFFFAOYSA-N	50352878	CHEMBL1824347	Beta-secretase 2			 780							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352878&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56682313	136359564		CHEMBL1824347				ZINC72183165	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660351	CN1C(N)=NC(C1=O)(c1ccsc1C)c1cccc(c1)-c1cncnc1	InChI=1S/C19H17N5OS/c1-12-16(6-7-26-12)19(17(25)24(2)18(20)23-19)15-5-3-4-13(8-15)14-9-21-11-22-10-14/h3-11H,1-2H3,(H2,20,23)	AWSZXXRYNSNVQU-UHFFFAOYSA-N	50352879	CHEMBL1824348	Beta-secretase 2			 610							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352879&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56678999	136359565		CHEMBL1824348				ZINC72183167	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660356	CCc1cc(cs1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C20H19N5OS/c1-3-17-8-16(11-27-17)20(18(26)25(2)19(21)24-20)15-6-4-5-13(7-15)14-9-22-12-23-10-14/h4-12H,3H2,1-2H3,(H2,21,24)	GAYCZOAOOLHOPO-UHFFFAOYSA-N	50352880	CHEMBL1824349	Beta-secretase 2			 560							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352880&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56668820	136359566		CHEMBL1824349				ZINC72183040	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660360	CCc1cc(c(C)s1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C21H21N5OS/c1-4-17-9-18(13(2)28-17)21(19(27)26(3)20(22)25-21)16-7-5-6-14(8-16)15-10-23-12-24-11-15/h5-12H,4H2,1-3H3,(H2,22,25)	VLFTWHOZHAMTTE-UHFFFAOYSA-N	50352881	CHEMBL1824350	Beta-secretase 2			 490							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352881&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56675694	136359567		CHEMBL1824350				ZINC72183042	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660363	CN1C(N)=NC(C1=O)(c1csc(Cl)c1)c1cccc(c1)-c1cncnc1	InChI=1S/C18H14ClN5OS/c1-24-16(25)18(23-17(24)20,14-6-15(19)26-9-14)13-4-2-3-11(5-13)12-7-21-10-22-8-12/h2-10H,1H3,(H2,20,23)	ABAOMGTVATUZIR-UHFFFAOYSA-N	50352882	CHEMBL1824351	Beta-secretase 2			 620							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352882&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56661918	136359568		CHEMBL1824351				ZINC72183503	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660366	CN1C(N)=NC(C1=O)(c1cc(C)sc1Cl)c1cccc(c1)-c1cncnc1	InChI=1S/C19H16ClN5OS/c1-11-6-15(16(20)27-11)19(17(26)25(2)18(21)24-19)14-5-3-4-12(7-14)13-8-22-10-23-9-13/h3-10H,1-2H3,(H2,21,24)	ZWXIWSLPGZVVNP-UHFFFAOYSA-N	50352883	CHEMBL1824352	Beta-secretase 2			 1150							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352883&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56658437	136359569		CHEMBL1824352				ZINC72183505	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660370	CCC(=O)c1cc(cs1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C21H19N5O2S/c1-3-17(27)18-8-16(11-29-18)21(19(28)26(2)20(22)25-21)15-6-4-5-13(7-15)14-9-23-12-24-10-14/h4-12H,3H2,1-2H3,(H2,22,25)	QKCQMQCRKHZUPK-UHFFFAOYSA-N	50352884	CHEMBL1824353	Beta-secretase 2			 70							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352884&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56672298	136359570		CHEMBL1824353				ZINC72183325	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660378	CN1C(N)=NC(C1=O)(c1ccsc1)c1cccc(c1)-c1cccnc1F	InChI=1S/C19H15FN4OS/c1-24-17(25)19(23-18(24)21,14-7-9-26-11-14)13-5-2-4-12(10-13)15-6-3-8-22-16(15)20/h2-11H,1H3,(H2,21,23)	VCKGJRZFNMIOEB-UHFFFAOYSA-N	50352886	CHEMBL1824355	Beta-secretase 2			 230							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352886&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56661919	136359572		CHEMBL1824355				ZINC72183327	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660382	CN1C(N)=NC(C1=O)(c1ccsc1)c1ccc(F)c(c1)-c1cccnc1	InChI=1S/C19H15FN4OS/c1-24-17(25)19(23-18(24)21,14-6-8-26-11-14)13-4-5-16(20)15(9-13)12-3-2-7-22-10-12/h2-11H,1H3,(H2,21,23)	SXYPETJOWBBGQK-UHFFFAOYSA-N	50352866	CHEMBL1824356	Beta-secretase 2			 740							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352866&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56679000	136359552		CHEMBL1824356				ZINC72183329	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660383	CN1C(N)=NC(C1=O)(c1cnn(CCF)c1)c1cccc(c1)-c1cccnc1F	InChI=1S/C20H18F2N6O/c1-27-18(29)20(26-19(27)23,15-11-25-28(12-15)9-7-21)14-5-2-4-13(10-14)16-6-3-8-24-17(16)22/h2-6,8,10-12H,7,9H2,1H3,(H2,23,26)	WTRPZTMQYKOUOO-UHFFFAOYSA-N	50352869	CHEMBL1824337	Beta-secretase 2			 650							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352869&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56672296	136359555		CHEMBL1824337				ZINC72182226	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50660387	CN1C(N)=NC(C1=O)(c1ccsc1)c1cccc(c1)-c1cccnc1	InChI=1S/C19H16N4OS/c1-23-17(24)19(22-18(23)20,16-7-9-25-12-16)15-6-2-4-13(10-15)14-5-3-8-21-11-14/h2-12H,1H3,(H2,20,22)	AOGBXAFIKRFUPJ-UHFFFAOYSA-N	50352885	CHEMBL1824354	Beta-secretase 2			 190							ChEMBL	10.1016/j.bmcl.2011.07.057	10.7270/Q2WQ045T	21835615			Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352885&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	532	3S7M	15949919	136359571		CHEMBL1824354				ZINC34803241	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705275	C[C@H](NC(=O)c1cc(cc(c1)-c1nc2ccccc2[nH]1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C24H24N4O3S/c1-16(17-9-5-4-6-10-17)25-24(29)19-13-18(14-20(15-19)28(2)32(3,30)31)23-26-21-11-7-8-12-22(21)27-23/h4-16H,1-3H3,(H,25,29)(H,26,27)/t16-/m0/s1	GCCLLOMNKKXXOF-INIZCTEOSA-N	50358931	CHEMBL1923700	Beta-secretase 2			 2130							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358931&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57401086	136962955		CHEMBL1923700				ZINC73160957	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705276	COc1ccc2nc([nH]c2c1)-c1cc(cc(c1)C(=O)N[C@@H](C)c1ccccc1)N(C)S(C)(=O)=O	InChI=1S/C25H26N4O4S/c1-16(17-8-6-5-7-9-17)26-25(30)19-12-18(13-20(14-19)29(2)34(4,31)32)24-27-22-11-10-21(33-3)15-23(22)28-24/h5-16H,1-4H3,(H,26,30)(H,27,28)/t16-/m0/s1	YYFIEQLEVGNNBQ-INIZCTEOSA-N	50358932	CHEMBL1923701	Beta-secretase 2			 2425							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358932&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57399319	136962956		CHEMBL1923701				ZINC73160960	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705277	C[C@H](NC(=O)c1cc(cc(c1)-c1nc2ccc(F)cc2[nH]1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C24H23FN4O3S/c1-15(16-7-5-4-6-8-16)26-24(30)18-11-17(12-20(13-18)29(2)33(3,31)32)23-27-21-10-9-19(25)14-22(21)28-23/h4-15H,1-3H3,(H,26,30)(H,27,28)/t15-/m0/s1	ZQYBOOXPGDXABH-HNNXBMFYSA-N	50358933	CHEMBL1923702	Beta-secretase 2			 2127							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358933&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57399320	136962957		CHEMBL1923702				ZINC73162244	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705278	C[C@H](NC(=O)c1cc(cc(c1)-c1nc(c[nH]1)-c1ccccc1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C26H26N4O3S/c1-18(19-10-6-4-7-11-19)28-26(31)22-14-21(15-23(16-22)30(2)34(3,32)33)25-27-17-24(29-25)20-12-8-5-9-13-20/h4-18H,1-3H3,(H,27,29)(H,28,31)/t18-/m0/s1	PSZITIHCSQMWAU-SFHVURJKSA-N	50358934	CHEMBL1923703	Beta-secretase 2			 1786							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358934&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57395865	136962958		CHEMBL1923703				ZINC73162249	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705279	COc1cccc(c1)-c1c[nH]c(n1)-c1cc(cc(c1)C(=O)N[C@@H](C)c1ccccc1)N(C)S(C)(=O)=O	InChI=1S/C27H28N4O4S/c1-18(19-9-6-5-7-10-19)29-27(32)22-13-21(14-23(15-22)31(2)36(4,33)34)26-28-17-25(30-26)20-11-8-12-24(16-20)35-3/h5-18H,1-4H3,(H,28,30)(H,29,32)/t18-/m0/s1	UCWXKESNYRGXEW-SFHVURJKSA-N	50358935	CHEMBL1923704	Beta-secretase 2			 2350							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358935&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57390575	136962959		CHEMBL1923704				ZINC73158301	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705280	C[C@H](NC(=O)c1cc(cc(c1)-c1nc(c[nH]1)-c1cccc(F)c1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C26H25FN4O3S/c1-17(18-8-5-4-6-9-18)29-26(32)21-12-20(14-23(15-21)31(2)35(3,33)34)25-28-16-24(30-25)19-10-7-11-22(27)13-19/h4-17H,1-3H3,(H,28,30)(H,29,32)/t17-/m0/s1	CIWFAULALHGEOR-KRWDZBQOSA-N	50358936	CHEMBL1923705	Beta-secretase 2			 1873							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358936&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57395866	136962960		CHEMBL1923705				ZINC73159770	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705281	CC(C)(C)Nc1c(nc2ccccn12)-c1ccc(cc1)-c1nc2ccccc2[nH]1	InChI=1S/C24H23N5/c1-24(2,3)28-23-21(27-20-10-6-7-15-29(20)23)16-11-13-17(14-12-16)22-25-18-8-4-5-9-19(18)26-22/h4-15,28H,1-3H3,(H,25,26)	BXZQUQFHFRDGNM-UHFFFAOYSA-N	50358937	CHEMBL1923706	Beta-secretase 2			 5675							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358937&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925448	136962961		CHEMBL1923706				ZINC73169469	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705282	CC(C)(C)Nc1c(nc2ccccn12)-c1ccc(cc1)-c1nc2ccc(F)cc2[nH]1	InChI=1S/C24H22FN5/c1-24(2,3)29-23-21(28-20-6-4-5-13-30(20)23)15-7-9-16(10-8-15)22-26-18-12-11-17(25)14-19(18)27-22/h4-14,29H,1-3H3,(H,26,27)	XFNVPLOSLDZYGA-UHFFFAOYSA-N	50358938	CHEMBL1923707	Beta-secretase 2			 3725							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358938&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925449	136962962		CHEMBL1923707				ZINC73169471	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705283	COc1ccc2nc([nH]c2c1)-c1ccc(cc1)-c1nc2ccccn2c1NC(C)(C)C	InChI=1S/C25H25N5O/c1-25(2,3)29-24-22(28-21-7-5-6-14-30(21)24)16-8-10-17(11-9-16)23-26-19-13-12-18(31-4)15-20(19)27-23/h5-15,29H,1-4H3,(H,26,27)	DEFXWAXUKYOGRK-UHFFFAOYSA-N	50358939	CHEMBL1923708	Beta-secretase 2			 2895							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358939&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925450	136962963		CHEMBL1923708				ZINC73170153	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705284	CC(C)(C)Nc1c(nc2ccccn12)-c1cccc(c1)-c1nc2ccccc2[nH]1	InChI=1S/C24H23N5/c1-24(2,3)28-23-21(27-20-13-6-7-14-29(20)23)16-9-8-10-17(15-16)22-25-18-11-4-5-12-19(18)26-22/h4-15,28H,1-3H3,(H,25,26)	RRIDTPCDKPIDBX-UHFFFAOYSA-N	50358940	CHEMBL1923709	Beta-secretase 2			 3785							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358940&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925452	136962964		CHEMBL1923709				ZINC73170154	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705285	CC(C)(C)Nc1c(nc2ccccn12)-c1cccc(c1)-c1nc2ccc(F)cc2[nH]1	InChI=1S/C24H22FN5/c1-24(2,3)29-23-21(28-20-9-4-5-12-30(20)23)15-7-6-8-16(13-15)22-26-18-11-10-17(25)14-19(18)27-22/h4-14,29H,1-3H3,(H,26,27)	IHFCIYLSNBQPNH-UHFFFAOYSA-N	50358941	CHEMBL1923749	Beta-secretase 2			 4234							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358941&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925453	136962965		CHEMBL1923749				ZINC73157600	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705286	COc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1nc2ccccn2c1NC(C)(C)C	InChI=1S/C25H25N5O/c1-25(2,3)29-24-22(28-21-10-5-6-13-30(21)24)16-8-7-9-17(14-16)23-26-19-12-11-18(31-4)15-20(19)27-23/h5-15,29H,1-4H3,(H,26,27)	ISCVINRUZPXLTR-UHFFFAOYSA-N	50358942	CHEMBL1923750	Beta-secretase 2			 4123							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358942&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925544	136962966		CHEMBL1923750				ZINC73159311	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705287	c1c(nc2ccccn12)-c1cccc(c1)-c1nc2ccccc2[nH]1	InChI=1S/C20H14N4/c1-2-9-17-16(8-1)22-20(23-17)15-7-5-6-14(12-15)18-13-24-11-4-3-10-19(24)21-18/h1-13H,(H,22,23)	GXKGMHZDCDTBEX-UHFFFAOYSA-N	50358927	CHEMBL1923751	Beta-secretase 2			 3890							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358927&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925547	136962951		CHEMBL1923751				ZINC73157605	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705288	Fc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1cn2ccccc2n1	InChI=1S/C20H13FN4/c21-15-7-8-16-17(11-15)24-20(23-16)14-5-3-4-13(10-14)18-12-25-9-2-1-6-19(25)22-18/h1-12H,(H,23,24)	BUKQLTRSESWIRN-UHFFFAOYSA-N	50358928	CHEMBL1923752	Beta-secretase 2			 3173							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358928&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925548	136962952		CHEMBL1923752				ZINC73141875	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705289	COc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1cn2ccccc2n1	InChI=1S/C21H16N4O/c1-26-16-8-9-17-18(12-16)24-21(23-17)15-6-4-5-14(11-15)19-13-25-10-3-2-7-20(25)22-19/h2-13H,1H3,(H,23,24)	ZYBLHCIRPQDYGD-UHFFFAOYSA-N	50358929	CHEMBL1923753	Beta-secretase 2			 3321							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358929&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925549	136962953		CHEMBL1923753				ZINC73196190	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705290	Fc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1cn2ccc(F)cc2n1	InChI=1S/C20H12F2N4/c21-14-4-5-16-17(9-14)25-20(24-16)13-3-1-2-12(8-13)18-11-26-7-6-15(22)10-19(26)23-18/h1-11H,(H,24,25)	HWDKGVNMSGILAJ-UHFFFAOYSA-N	50358930	CHEMBL1923754	Beta-secretase 2			 3675							ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358930&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56834873	136962954		CHEMBL1923754				ZINC73170228	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705307	C[C@H](NC(=O)c1cc(cc(c1)-c1nc2ccccc2[nH]1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C24H24N4O3S/c1-16(17-9-5-4-6-10-17)25-24(29)19-13-18(14-20(15-19)28(2)32(3,30)31)23-26-21-11-7-8-12-22(21)27-23/h4-16H,1-3H3,(H,25,29)(H,26,27)/t16-/m0/s1	GCCLLOMNKKXXOF-INIZCTEOSA-N	50358931	CHEMBL1923700	Beta-secretase 2		 2067								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358931&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57401086	136962955		CHEMBL1923700				ZINC73160957	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705308	COc1ccc2nc([nH]c2c1)-c1cc(cc(c1)C(=O)N[C@@H](C)c1ccccc1)N(C)S(C)(=O)=O	InChI=1S/C25H26N4O4S/c1-16(17-8-6-5-7-9-17)26-25(30)19-12-18(13-20(14-19)29(2)34(4,31)32)24-27-22-11-10-21(33-3)15-23(22)28-24/h5-16H,1-4H3,(H,26,30)(H,27,28)/t16-/m0/s1	YYFIEQLEVGNNBQ-INIZCTEOSA-N	50358932	CHEMBL1923701	Beta-secretase 2		 2354								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358932&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57399319	136962956		CHEMBL1923701				ZINC73160960	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705309	C[C@H](NC(=O)c1cc(cc(c1)-c1nc2ccc(F)cc2[nH]1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C24H23FN4O3S/c1-15(16-7-5-4-6-8-16)26-24(30)18-11-17(12-20(13-18)29(2)33(3,31)32)23-27-21-10-9-19(25)14-22(21)28-23/h4-15H,1-3H3,(H,26,30)(H,27,28)/t15-/m0/s1	ZQYBOOXPGDXABH-HNNXBMFYSA-N	50358933	CHEMBL1923702	Beta-secretase 2		 2065								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358933&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57399320	136962957		CHEMBL1923702				ZINC73162244	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705310	C[C@H](NC(=O)c1cc(cc(c1)-c1nc(c[nH]1)-c1ccccc1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C26H26N4O3S/c1-18(19-10-6-4-7-11-19)28-26(31)22-14-21(15-23(16-22)30(2)34(3,32)33)25-27-17-24(29-25)20-12-8-5-9-13-20/h4-18H,1-3H3,(H,27,29)(H,28,31)/t18-/m0/s1	PSZITIHCSQMWAU-SFHVURJKSA-N	50358934	CHEMBL1923703	Beta-secretase 2		 1733								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358934&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57395865	136962958		CHEMBL1923703				ZINC73162249	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705311	COc1cccc(c1)-c1c[nH]c(n1)-c1cc(cc(c1)C(=O)N[C@@H](C)c1ccccc1)N(C)S(C)(=O)=O	InChI=1S/C27H28N4O4S/c1-18(19-9-6-5-7-10-19)29-27(32)22-13-21(14-23(15-22)31(2)36(4,33)34)26-28-17-25(30-26)20-11-8-12-24(16-20)35-3/h5-18H,1-4H3,(H,28,30)(H,29,32)/t18-/m0/s1	UCWXKESNYRGXEW-SFHVURJKSA-N	50358935	CHEMBL1923704	Beta-secretase 2		 2281								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358935&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57390575	136962959		CHEMBL1923704				ZINC73158301	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705312	C[C@H](NC(=O)c1cc(cc(c1)-c1nc(c[nH]1)-c1cccc(F)c1)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C26H25FN4O3S/c1-17(18-8-5-4-6-9-18)29-26(32)21-12-20(14-23(15-21)31(2)35(3,33)34)25-28-16-24(30-25)19-10-7-11-22(27)13-19/h4-17H,1-3H3,(H,28,30)(H,29,32)/t17-/m0/s1	CIWFAULALHGEOR-KRWDZBQOSA-N	50358936	CHEMBL1923705	Beta-secretase 2		 1818								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358936&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57395866	136962960		CHEMBL1923705				ZINC73159770	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705313	CC(C)(C)Nc1c(nc2ccccn12)-c1ccc(cc1)-c1nc2ccccc2[nH]1	InChI=1S/C24H23N5/c1-24(2,3)28-23-21(27-20-10-6-7-15-29(20)23)16-11-13-17(14-12-16)22-25-18-8-4-5-9-19(18)26-22/h4-15,28H,1-3H3,(H,25,26)	BXZQUQFHFRDGNM-UHFFFAOYSA-N	50358937	CHEMBL1923706	Beta-secretase 2		 5509								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358937&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925448	136962961		CHEMBL1923706				ZINC73169469	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705314	CC(C)(C)Nc1c(nc2ccccn12)-c1ccc(cc1)-c1nc2ccc(F)cc2[nH]1	InChI=1S/C24H22FN5/c1-24(2,3)29-23-21(28-20-6-4-5-13-30(20)23)15-7-9-16(10-8-15)22-26-18-12-11-17(25)14-19(18)27-22/h4-14,29H,1-3H3,(H,26,27)	XFNVPLOSLDZYGA-UHFFFAOYSA-N	50358938	CHEMBL1923707	Beta-secretase 2		 3617								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358938&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925449	136962962		CHEMBL1923707				ZINC73169471	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705315	COc1ccc2nc([nH]c2c1)-c1ccc(cc1)-c1nc2ccccn2c1NC(C)(C)C	InChI=1S/C25H25N5O/c1-25(2,3)29-24-22(28-21-7-5-6-14-30(21)24)16-8-10-17(11-9-16)23-26-19-13-12-18(31-4)15-20(19)27-23/h5-15,29H,1-4H3,(H,26,27)	DEFXWAXUKYOGRK-UHFFFAOYSA-N	50358939	CHEMBL1923708	Beta-secretase 2		 2810								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358939&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925450	136962963		CHEMBL1923708				ZINC73170153	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705316	CC(C)(C)Nc1c(nc2ccccn12)-c1cccc(c1)-c1nc2ccccc2[nH]1	InChI=1S/C24H23N5/c1-24(2,3)28-23-21(27-20-13-6-7-14-29(20)23)16-9-8-10-17(15-16)22-25-18-11-4-5-12-19(18)26-22/h4-15,28H,1-3H3,(H,25,26)	RRIDTPCDKPIDBX-UHFFFAOYSA-N	50358940	CHEMBL1923709	Beta-secretase 2		 3674								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358940&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925452	136962964		CHEMBL1923709				ZINC73170154	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705317	CC(C)(C)Nc1c(nc2ccccn12)-c1cccc(c1)-c1nc2ccc(F)cc2[nH]1	InChI=1S/C24H22FN5/c1-24(2,3)29-23-21(28-20-9-4-5-12-30(20)23)15-7-6-8-16(13-15)22-26-18-11-10-17(25)14-19(18)27-22/h4-14,29H,1-3H3,(H,26,27)	IHFCIYLSNBQPNH-UHFFFAOYSA-N	50358941	CHEMBL1923749	Beta-secretase 2		 4110								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358941&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925453	136962965		CHEMBL1923749				ZINC73157600	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705318	COc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1nc2ccccn2c1NC(C)(C)C	InChI=1S/C25H25N5O/c1-25(2,3)29-24-22(28-21-10-5-6-13-30(21)24)16-8-7-9-17(14-16)23-26-19-12-11-18(31-4)15-20(19)27-23/h5-15,29H,1-4H3,(H,26,27)	ISCVINRUZPXLTR-UHFFFAOYSA-N	50358942	CHEMBL1923750	Beta-secretase 2		 4003								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358942&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925544	136962966		CHEMBL1923750				ZINC73159311	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705319	c1c(nc2ccccn12)-c1cccc(c1)-c1nc2ccccc2[nH]1	InChI=1S/C20H14N4/c1-2-9-17-16(8-1)22-20(23-17)15-7-5-6-14(12-15)18-13-24-11-4-3-10-19(24)21-18/h1-13H,(H,22,23)	GXKGMHZDCDTBEX-UHFFFAOYSA-N	50358927	CHEMBL1923751	Beta-secretase 2		 3777								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358927&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925547	136962951		CHEMBL1923751				ZINC73157605	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705320	Fc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1cn2ccccc2n1	InChI=1S/C20H13FN4/c21-15-7-8-16-17(11-15)24-20(23-16)14-5-3-4-13(10-14)18-12-25-9-2-1-6-19(25)22-18/h1-12H,(H,23,24)	BUKQLTRSESWIRN-UHFFFAOYSA-N	50358928	CHEMBL1923752	Beta-secretase 2		 3081								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358928&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925548	136962952		CHEMBL1923752				ZINC73141875	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705321	COc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1cn2ccccc2n1	InChI=1S/C21H16N4O/c1-26-16-8-9-17-18(12-16)24-21(23-17)15-6-4-5-14(11-15)19-13-25-10-3-2-7-20(25)22-19/h2-13H,1H3,(H,23,24)	ZYBLHCIRPQDYGD-UHFFFAOYSA-N	50358929	CHEMBL1923753	Beta-secretase 2		 3224								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358929&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56925549	136962953		CHEMBL1923753				ZINC73196190	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50705322	Fc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1cn2ccc(F)cc2n1	InChI=1S/C20H12F2N4/c21-14-4-5-16-17(9-14)25-20(24-16)13-3-1-2-12(8-13)18-11-26-7-6-15(22)10-19(26)23-18/h1-11H,(H,24,25)	HWDKGVNMSGILAJ-UHFFFAOYSA-N	50358930	CHEMBL1923754	Beta-secretase 2		 3568								ChEMBL	10.1021/jm201181f	10.7270/Q279453T	22044119			Al-Tel, TH; Semreen, MH; Al-Qawasmeh, RA; Schmidt, MF; El-Awadi, R; Ardah, M; Zaarour, R; Rao, SN; El-Agnaf, O	University of Sharjah	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358930&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56834873	136962954		CHEMBL1923754				ZINC73170228	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50709782	Clc1ccc2c(CCC[C@]22CNC[C@H]2C(=O)N2CC[C@H](C[C@H]2C2CCCCC2)c2ccccc2)n1	InChI=1S/C30H38ClN3O/c31-28-14-13-24-26(33-28)12-7-16-30(24)20-32-19-25(30)29(35)34-17-15-23(21-8-3-1-4-9-21)18-27(34)22-10-5-2-6-11-22/h1,3-4,8-9,13-14,22-23,25,27,32H,2,5-7,10-12,15-20H2/t23-,25+,27+,30+/m1/s1	BVBQXGDSJPQNKF-PCUPTAKISA-N	50360723	CHEMBL1934295	Beta-secretase 2			 29							ChEMBL	10.1016/j.bmcl.2011.11.024	10.7270/Q2QR4XJK	22130130			Stachel, SJ; Steele, TG; Petrocchi, A; Haugabook, SJ; McGaughey, G; Katharine Holloway, M; Allison, T; Munshi, S; Zuck, P; Colussi, D; Tugasheva, K; Wolfe, A; Graham, SL; Vacca, JP	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50360723	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50360723&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			56834949	136964785		CHEMBL1934295				ZINC73221381	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50740871	CSCC[C@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCc1ccccc1	InChI=1S/C37H63N5O7S/c1-22(2)19-28(29(43)20-25(7)32(44)41-30(23(3)4)34(46)38-21-26-15-13-12-14-16-26)40-33(45)27(17-18-50-11)39-35(47)31(24(5)6)42-36(48)49-37(8,9)10/h12-16,22-25,27-31,43H,17-21H2,1-11H3,(H,38,46)(H,39,47)(H,40,45)(H,41,44)(H,42,48)/t25-,27+,28+,29+,30+,31+/m1/s1	OTAKXFOXYSLTCG-KNSFHFJMSA-N	16250	CHEMBL290001::N-(tert-butoxycarbonyl)-L-valyl-N-[(1S,2S,4R)-5-{[(1S)-1-(benzylcarbamoyl)-2-methylpropyl]amino}-2-hydroxy-4-methyl-1-(2-methylpropyl)-5-oxopentyl]-L-methioninamide::Substrate-based BACE-1 inhibitor, 22::Tang hydroxyethylene inhibitor::peptidomimetic memapsin 2 inhibitor 2::tert-butyl N-[(1S)-1-{[(1S)-1-{[(1R,3S,4S)-1-{[(1S)-1-(benzylcarbamoyl)-2-methylpropyl]carbamoyl}-3-hydroxy-1,6-dimethylheptan-4-yl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}-2-methylpropyl]carbamate	Beta-secretase 2			 500							ChEMBL	10.1016/j.bmcl.2003.09.084	10.7270/Q2MW2HP3	14684335			Lamar, J; Hu, J; Bueno, AB; Yang, HC; Guo, D; Copp, JD; McGee, J; Gitter, B; Timm, D; May, P; McCarthy, J; Chen, SH	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10212352	46516094		CHEMBL290001				ZINC26176801	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50856191	CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)Oc1ccccc1	InChI=1S/C34H41F2N3O4/c1-4-11-39(12-5-2)34(42)25-14-22(3)13-24(18-25)33(41)38-31(17-23-15-26(35)19-27(36)16-23)32(40)30-20-29(21-37-30)43-28-9-7-6-8-10-28/h6-10,13-16,18-19,29-32,37,40H,4-5,11-12,17,20-21H2,1-3H3,(H,38,41)/t29-,30-,31+,32-/m1/s1	YDCNYSQITCUGST-FEFKUCBWSA-N	50372181	CHEMBL403727	Beta-secretase 2			 54							ChEMBL	10.1016/j.bmcl.2007.10.116	10.7270/Q2RV0PJH	18023580			Iserloh, U; Wu, Y; Cumming, JN; Pan, J; Wang, LY; Stamford, AW; Kennedy, ME; Kuvelkar, R; Chen, X; Parker, EM; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50372181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50372181&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CS9	2QMF	11614083	160851282		CHEMBL403727				ZINC16052458	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50856228	CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C35H43F2N3O4/c1-4-11-40(12-5-2)35(43)27-14-23(3)13-26(18-27)34(42)39-32(17-25-15-28(36)19-29(37)16-25)33(41)31-20-30(21-38-31)44-22-24-9-7-6-8-10-24/h6-10,13-16,18-19,30-33,38,41H,4-5,11-12,17,20-22H2,1-3H3,(H,39,42)/t30-,31-,32+,33-/m1/s1	GZHSLBYVXGDJDF-NXVJRICRSA-N	50372198	CHEMBL270359	Beta-secretase 2			 45							ChEMBL	10.1016/j.bmcl.2007.10.116	10.7270/Q2RV0PJH	18023580			Iserloh, U; Wu, Y; Cumming, JN; Pan, J; Wang, LY; Stamford, AW; Kennedy, ME; Kuvelkar, R; Chen, X; Parker, EM; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50372198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50372198&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CS7	2QMD	11556254	160851299		CHEMBL270359				ZINC16052459	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860276	CCCc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C33H46N4O4/c1-3-11-25-18-26(21-28(19-25)37-17-10-16-31(37)39)33(41)36-29(20-24-12-6-4-7-13-24)30(38)22-34-23(2)32(40)35-27-14-8-5-9-15-27/h4,6-7,12-13,18-19,21,23,27,29-30,34,38H,3,5,8-11,14-17,20,22H2,1-2H3,(H,35,40)(H,36,41)/t23-,29-,30+/m0/s1	WQAFOQHZNVQHFW-KEPSJGTLSA-N	50373804	CHEMBL257871	Beta-secretase 2			 1580							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373804&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454839	160852905		CHEMBL257871				ZINC29128163	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860277	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(cc(c1)N1CCCC1=O)N1CCCC1)C(=O)NC1CCCCC1	InChI=1S/C34H47N5O4/c1-24(33(42)36-27-13-6-3-7-14-27)35-23-31(40)30(19-25-11-4-2-5-12-25)37-34(43)26-20-28(38-16-8-9-17-38)22-29(21-26)39-18-10-15-32(39)41/h2,4-5,11-12,20-22,24,27,30-31,35,40H,3,6-10,13-19,23H2,1H3,(H,36,42)(H,37,43)/t24-,30-,31+/m0/s1	JMVWEZMBTQMNME-RJSONGRPSA-N	50373799	CHEMBL255192	Beta-secretase 2			 8793							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373799&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454842	160852900		CHEMBL255192				ZINC29128166	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860278	CC(C)CNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C34H49N5O4/c1-23(2)21-36-28-18-26(19-29(20-28)39-16-10-15-32(39)41)34(43)38-30(17-25-11-6-4-7-12-25)31(40)22-35-24(3)33(42)37-27-13-8-5-9-14-27/h4,6-7,11-12,18-20,23-24,27,30-31,35-36,40H,5,8-10,13-17,21-22H2,1-3H3,(H,37,42)(H,38,43)/t24-,30-,31+/m0/s1	ZQPHLZSMHOLSCJ-RJSONGRPSA-N	50373805	CHEMBL255964	Beta-secretase 2			 650							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373805&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454875	160852906		CHEMBL255964				ZINC29128225	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860279	CC(C)Nc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C33H47N5O4/c1-22(2)35-27-18-25(19-28(20-27)38-16-10-15-31(38)40)33(42)37-29(17-24-11-6-4-7-12-24)30(39)21-34-23(3)32(41)36-26-13-8-5-9-14-26/h4,6-7,11-12,18-20,22-23,26,29-30,34-35,39H,5,8-10,13-17,21H2,1-3H3,(H,36,41)(H,37,42)/t23-,29-,30+/m0/s1	SNDQIKFTGSEGEF-KEPSJGTLSA-N	50373806	CHEMBL227053	Beta-secretase 2			 830							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373806&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454874	160852907		CHEMBL227053				ZINC29128224	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860280	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C32H45N5O4/c1-3-33-26-18-24(19-27(20-26)37-16-10-15-30(37)39)32(41)36-28(17-23-11-6-4-7-12-23)29(38)21-34-22(2)31(40)35-25-13-8-5-9-14-25/h4,6-7,11-12,18-20,22,25,28-29,33-34,38H,3,5,8-10,13-17,21H2,1-2H3,(H,35,40)(H,36,41)/t22-,28-,29+/m0/s1	ARWMRRUIIHCDKG-PWUSVURUSA-N	50231682	CHEMBL251862::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 1810							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231682	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231682&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG5	2XFJ,2VJ6	24882338	104055249		CHEMBL251862				ZINC28978361	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860281	CCCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C33H46N4O5/c1-3-17-42-28-20-25(19-27(21-28)37-16-10-15-31(37)39)33(41)36-29(18-24-11-6-4-7-12-24)30(38)22-34-23(2)32(40)35-26-13-8-5-9-14-26/h4,6-7,11-12,19-21,23,26,29-30,34,38H,3,5,8-10,13-18,22H2,1-2H3,(H,35,40)(H,36,41)/t23-,29-,30+/m0/s1	NFJZOPIVPQPDRI-KEPSJGTLSA-N	50373807	CHEMBL272714	Beta-secretase 2			 8235							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373807&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454914	160852908		CHEMBL272714				ZINC29128287	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860282	CCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1	InChI=1S/C32H46N4O4/c1-3-40-28-20-25(19-27(21-28)36-16-10-11-17-36)32(39)35-29(18-24-12-6-4-7-13-24)30(37)22-33-23(2)31(38)34-26-14-8-5-9-15-26/h4,6-7,12-13,19-21,23,26,29-30,33,37H,3,5,8-11,14-18,22H2,1-2H3,(H,34,38)(H,35,39)/t23-,29-,30+/m0/s1	HVFZUMJBEDTECP-KEPSJGTLSA-N	50373808	CHEMBL403533	Beta-secretase 2			 12880							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373808&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454913	160852909		CHEMBL403533				ZINC29128286	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860283	CCCCCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C35H50N4O5/c1-3-4-11-19-44-30-22-27(21-29(23-30)39-18-12-17-33(39)41)35(43)38-31(20-26-13-7-5-8-14-26)32(40)24-36-25(2)34(42)37-28-15-9-6-10-16-28/h5,7-8,13-14,21-23,25,28,31-32,36,40H,3-4,6,9-12,15-20,24H2,1-2H3,(H,37,42)(H,38,43)/t25-,31-,32+/m0/s1	FWXBKZGTGOEOEX-FWGANANOSA-N	50373809	CHEMBL256399	Beta-secretase 2			 400							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373809&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454945	160852910		CHEMBL256399				ZINC29128349	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860284	CC(C)Oc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C33H46N4O5/c1-22(2)42-28-19-25(18-27(20-28)37-16-10-15-31(37)39)33(41)36-29(17-24-11-6-4-7-12-24)30(38)21-34-23(3)32(40)35-26-13-8-5-9-14-26/h4,6-7,11-12,18-20,22-23,26,29-30,34,38H,5,8-10,13-17,21H2,1-3H3,(H,35,40)(H,36,41)/t23-,29-,30+/m0/s1	AFLKXDWNKYXERG-KEPSJGTLSA-N	50373800	CHEMBL255977	Beta-secretase 2			 4790							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373800&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454944	160852901		CHEMBL255977				ZINC29128348	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860285	CCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C32H44N4O5/c1-3-41-27-19-24(18-26(20-27)36-16-10-15-30(36)38)32(40)35-28(17-23-11-6-4-7-12-23)29(37)21-33-22(2)31(39)34-25-13-8-5-9-14-25/h4,6-7,11-12,18-20,22,25,28-29,33,37H,3,5,8-10,13-17,21H2,1-2H3,(H,34,39)(H,35,40)/t22-,28-,29+/m0/s1	FBDCQORXLIVIPH-PWUSVURUSA-N	50373810	CHEMBL258068	Beta-secretase 2			 5130							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373810&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454508	160852911		CHEMBL258068				ZINC29127596	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860286	COc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C31H42N4O5/c1-21(30(38)33-24-12-7-4-8-13-24)32-20-28(36)27(16-22-10-5-3-6-11-22)34-31(39)23-17-25(19-26(18-23)40-2)35-15-9-14-29(35)37/h3,5-6,10-11,17-19,21,24,27-28,32,36H,4,7-9,12-16,20H2,1-2H3,(H,33,38)(H,34,39)/t21-,27-,28+/m0/s1	MLTMAABMXBCIEM-YNOBPPCASA-N	50373811	CHEMBL258277	Beta-secretase 2			 28600							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373811&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454509	160852912		CHEMBL258277				ZINC29127597	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860287	CCCCCS(=O)(=O)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1	InChI=1S/C31H45N3O5S/c1-3-4-11-19-40(38,39)27-18-12-15-25(21-27)31(37)34-28(20-24-13-7-5-8-14-24)29(35)22-32-23(2)30(36)33-26-16-9-6-10-17-26/h5,7-8,12-15,18,21,23,26,28-29,32,35H,3-4,6,9-11,16-17,19-20,22H2,1-2H3,(H,33,36)(H,34,37)/t23-,28-,29+/m0/s1	FBMGVFBNGKNQCB-WTWMYVDVSA-N	50373812	CHEMBL402305	Beta-secretase 2			 3600							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373812&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG3	2VIY	23657804	160852913		CHEMBL402305				ZINC16052614	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860288	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc(NC(C)=O)cc1)C(=O)NC1CCCCC1	InChI=1S/C28H38N4O4/c1-19(27(35)31-23-11-7-4-8-12-23)29-18-26(34)25(17-21-9-5-3-6-10-21)32-28(36)22-13-15-24(16-14-22)30-20(2)33/h3,5-6,9-10,13-16,19,23,25-26,29,34H,4,7-8,11-12,17-18H2,1-2H3,(H,30,33)(H,31,35)(H,32,36)/t19-,25-,26+/m0/s1	ROSDPTSFBCNKOB-RRWZXMNXSA-N	50373801	CHEMBL271231	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373801&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454542	160852902		CHEMBL271231				ZINC29127648	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860289	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N1CCCC1=O)C(=O)NC1CCCCC1	InChI=1S/C30H40N4O4/c1-21(29(37)32-24-13-6-3-7-14-24)31-20-27(35)26(18-22-10-4-2-5-11-22)33-30(38)23-12-8-15-25(19-23)34-17-9-16-28(34)36/h2,4-5,8,10-12,15,19,21,24,26-27,31,35H,3,6-7,9,13-14,16-18,20H2,1H3,(H,32,37)(H,33,38)/t21-,26-,27+/m0/s1	NUXXROATVMQIKI-NJTBCWBZSA-N	50322878	CHEMBL271230::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 78530							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322878&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454541	117644199		CHEMBL271230				ZINC29127647	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860290	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N1CCCS1(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C29H40N4O5S/c1-21(28(35)31-24-13-6-3-7-14-24)30-20-27(34)26(18-22-10-4-2-5-11-22)32-29(36)23-12-8-15-25(19-23)33-16-9-17-39(33,37)38/h2,4-5,8,10-12,15,19,21,24,26-27,30,34H,3,6-7,9,13-14,16-18,20H2,1H3,(H,31,35)(H,32,36)/t21-,26-,27+/m0/s1	PXYHFUBZOJLFQW-NJTBCWBZSA-N	50373813	CHEMBL271437	Beta-secretase 2			>21000							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373813&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454543	160852914		CHEMBL271437				ZINC29127650	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879239	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@@H](CC1)OC)-c1cncc(C)c1	InChI=1S/C23H27N3O2/c1-15-9-18(13-25-12-15)16-3-4-17-11-22(7-5-19(27-2)6-8-22)23(20(17)10-16)14-28-21(24)26-23/h3-4,9-10,12-13,19H,5-8,11,14H2,1-2H3,(H2,24,26)/t19-,22-,23-/m0/s1/i14D2	XMEKMASQQBIQCX-MMGYNXNYSA-N	50264194	CHEMBL4093123	Beta-secretase 2		 710								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264194&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137653017	404341756							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879242	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@@H](CC1)OC)-c1cncnc1	InChI=1S/C21H24N4O2/c1-26-17-4-6-20(7-5-17)9-15-3-2-14(16-10-23-13-24-11-16)8-18(15)21(20)12-27-19(22)25-21/h2-3,8,10-11,13,17H,4-7,9,12H2,1H3,(H2,22,25)/t17-,20-,21-/m0/s1/i12D2	HCULHXVLYCNDEI-QKRXBBJISA-N	50264181	CHEMBL4065448	Beta-secretase 2		 2077								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264181&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			132054902	404341748							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879260	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@]11CC[C@@H](OC)[C@H](C)C1)-c1cncnc1	InChI=1S/C22H26N4O2/c1-14-8-21(6-5-19(14)27-2)9-16-4-3-15(17-10-24-13-25-11-17)7-18(16)22(21)12-28-20(23)26-22/h3-4,7,10-11,13-14,19H,5-6,8-9,12H2,1-2H3,(H2,23,26)/t14-,19-,21-,22+/m1/s1/i12D2	LNZBKHMXPFCMOB-OCTYJMGUSA-N	50264195	CHEMBL4103296	Beta-secretase 2		 1299								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264195&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			132054828	404341757							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879261	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@]11CC[C@@H](OC)[C@H](CC)C1)-c1cncnc1	InChI=1S/C23H28N4O2/c1-3-15-9-22(7-6-20(15)28-2)10-17-5-4-16(18-11-25-14-26-12-18)8-19(17)23(22)13-29-21(24)27-23/h4-5,8,11-12,14-15,20H,3,6-7,9-10,13H2,1-2H3,(H2,24,27)/t15-,20-,22-,23+/m1/s1/i13D2	XWPKJWXXVQEOTC-STERQVHBSA-N	50264184	CHEMBL4097477	Beta-secretase 2		 443								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264184&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			132054950	404341750							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879606	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@H](OC)[C@@H](C)C1)-c1cncnc1	InChI=1S/C22H26N4O2/c1-14-8-21(6-5-19(14)27-2)9-16-4-3-15(17-10-24-13-25-11-17)7-18(16)22(21)12-28-20(23)26-22/h3-4,7,10-11,13-14,19H,5-6,8-9,12H2,1-2H3,(H2,23,26)/t14-,19-,21-,22-/m0/s1/i12D2	LNZBKHMXPFCMOB-NIVWZPTPSA-N	50264185	CHEMBL4070299	Beta-secretase 2		 817								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264185&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137638912	404341751							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879658	CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22COC(N)=N2)-c2cc(Cl)cc(c2)C#N)CC1	InChI=1S/C24H24ClN3O2/c1-29-20-4-6-23(7-5-20)12-17-3-2-16(18-8-15(13-26)9-19(25)10-18)11-21(17)24(23)14-30-22(27)28-24/h2-3,8-11,20H,4-7,12,14H2,1H3,(H2,27,28)/t20-,23-,24-/m0/s1	FQJNFWHRRHDNQF-OYDLWJJNSA-N	50264192	CHEMBL4072118	Beta-secretase 2		 13								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264192&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			132068809	404341754							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879659	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@@H](CC1)OC)-c1cccnc1	InChI=1S/C22H25N3O2/c1-26-18-6-8-21(9-7-18)12-16-5-4-15(17-3-2-10-24-13-17)11-19(16)22(21)14-27-20(23)25-22/h2-5,10-11,13,18H,6-9,12,14H2,1H3,(H2,23,25)/t18-,21-,22-/m0/s1/i14D2	GEYWBDIFOOXJFR-JPJSVPEHSA-N	50264180	CHEMBL4074071	Beta-secretase 2		 1478								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264180&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137641085	404341747							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879663	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@]11C[C@H](C)[C@@H](OC)[C@H](C)C1)-c1cncnc1	InChI=1S/C23H28N4O2/c1-14-7-22(8-15(2)20(14)28-3)9-17-5-4-16(18-10-25-13-26-11-18)6-19(17)23(22)12-29-21(24)27-23/h4-6,10-11,13-15,20H,7-9,12H2,1-3H3,(H2,24,27)/t14-,15+,20+,22+,23-/m0/s1/i12D2	WEUYFLJIIPRWIS-AQYDYDSLSA-N	50264183	CHEMBL4085364	Beta-secretase 2		 1011								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264183&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137646591	404341749							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50879666	[2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@H](OC)[C@@H](CC)C1)-c1cncnc1	InChI=1S/C23H28N4O2/c1-3-15-9-22(7-6-20(15)28-2)10-17-5-4-16(18-11-25-14-26-12-18)8-19(17)23(22)13-29-21(24)27-23/h4-5,8,11-12,14-15,20H,3,6-7,9-10,13H2,1-2H3,(H2,24,27)/t15-,20-,22-,23-/m0/s1/i13D2	XWPKJWXXVQEOTC-CXPDZNFNSA-N	50264186	CHEMBL4067413	Beta-secretase 2		 2022								ChEMBL	10.1021/acs.jmedchem.7b01716	10.7270/Q2TX3HVX	29617572			Johansson, P; Kaspersson, K; Gurrell, IK; Bäck, E; Eketjäll, S; Scott, CW; Cebers, G; Thorne, P; McKenzie, MJ; Beaton, H; Davey, P; Kolmodin, K; Holenz, J; Duggan, ME; Budd Haeberlein, S; Bürli, RW	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264186&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			132054712	404341752							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50860260	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C27H37N3O5S/c1-19(26(32)29-22-13-7-4-8-14-22)28-18-25(31)24(16-20-10-5-3-6-11-20)30-27(33)21-12-9-15-23(17-21)36(2,34)35/h3,5-6,9-12,15,17,19,22,24-25,28,31H,4,7-8,13-14,16,18H2,1-2H3,(H,29,32)(H,30,33)/t19-,24-,25+/m0/s1	YKYXAHIQYWIJPR-PNTFMKQHSA-N	50231691	CHEMBL402120::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(methylsulfonyl)benzamide	Beta-secretase 2			 42000							ChEMBL	10.1016/j.bmcl.2007.12.017	10.7270/Q2PG1SK5	18171614			Clarke, B; Demont, E; Dingwall, C; Dunsdon, R; Faller, A; Hawkins, J; Hussain, I; MacPherson, D; Maile, G; Matico, R; Milner, P; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Riddell, D; Rowland, P; Soleil, V; Smith, KJ; Stanway, S; Stemp, G; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Ward, J; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231691	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231691&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44446196	104055258		CHEMBL402120				ZINC28978356	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861550	CCCCCN1C[C@H]([C@H](Cc2ccccc2)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C37H45F2N3O4/c1-2-3-10-15-42-23-32(31(37(42)45)18-25-11-6-4-7-12-25)36(44)41-34(19-27-16-28(38)20-29(39)17-27)35(43)33-21-30(22-40-33)46-24-26-13-8-5-9-14-26/h4-9,11-14,16-17,20,30-35,40,43H,2-3,10,15,18-19,21-24H2,1H3,(H,41,44)/t30-,31+,32-,33-,34+,35-/m1/s1	HKTSYBSUGBDMKQ-BPDVJUFUSA-N	50374237	CHEMBL255400	Beta-secretase 2			 4000							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455462	160853327		CHEMBL255400				ZINC29129118	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861551	CCCCCN1C[C@H]([C@H](C2CCCC2)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C35H47F2N3O4/c1-2-3-9-14-40-21-29(32(35(40)43)25-12-7-8-13-25)34(42)39-31(17-24-15-26(36)18-27(37)16-24)33(41)30-19-28(20-38-30)44-22-23-10-5-4-6-11-23/h4-6,10-11,15-16,18,25,28-33,38,41H,2-3,7-9,12-14,17,19-22H2,1H3,(H,39,42)/t28-,29-,30-,31+,32+,33-/m1/s1	GEZOBYGDQAVHMG-WGNKJVRNSA-N	50374223	CHEMBL403253	Beta-secretase 2			 4250							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455487	160853313		CHEMBL403253				ZINC29129161	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861552	CCCCCN1C[C@H]([C@H](C2CC2)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C33H43F2N3O4/c1-2-3-7-12-38-19-27(30(33(38)41)23-10-11-23)32(40)37-29(15-22-13-24(34)16-25(35)14-22)31(39)28-17-26(18-36-28)42-20-21-8-5-4-6-9-21/h4-6,8-9,13-14,16,23,26-31,36,39H,2-3,7,10-12,15,17-20H2,1H3,(H,37,40)/t26-,27-,28-,29+,30+,31-/m1/s1	HHFXRPPCGYBTGG-FNBYOJNGSA-N	50374224	CHEMBL403050	Beta-secretase 2			 2400							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374224&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455486	160853314		CHEMBL403050				ZINC29129160	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861553	CCCCN1C[C@H]([C@H](CC(C)C)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C33H45F2N3O4/c1-4-5-11-38-19-28(27(33(38)41)12-21(2)3)32(40)37-30(15-23-13-24(34)16-25(35)14-23)31(39)29-17-26(18-36-29)42-20-22-9-7-6-8-10-22/h6-10,13-14,16,21,26-31,36,39H,4-5,11-12,15,17-20H2,1-3H3,(H,37,40)/t26-,27+,28-,29-,30+,31-/m1/s1	SQTISKBGLRIMMR-ISYGQMQOSA-N	50374225	CHEMBL403108	Beta-secretase 2			 260							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374225&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455515	160853315		CHEMBL403108				ZINC29129208	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861554	CCCCN1C[C@H]([C@H](CCC)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C32H43F2N3O4/c1-3-5-12-37-19-27(26(9-4-2)32(37)40)31(39)36-29(15-22-13-23(33)16-24(34)14-22)30(38)28-17-25(18-35-28)41-20-21-10-7-6-8-11-21/h6-8,10-11,13-14,16,25-30,35,38H,3-5,9,12,15,17-20H2,1-2H3,(H,36,39)/t25-,26+,27-,28-,29+,30-/m1/s1	JZNBSMOUXMVJJI-IVPISEAZSA-N	50374226	CHEMBL404369	Beta-secretase 2			 330							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374226&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455514	160853316		CHEMBL404369				ZINC29129207	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861555	CCCCN1C[C@H]([C@H](CC)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C31H41F2N3O4/c1-3-5-11-36-18-26(25(4-2)31(36)39)30(38)35-28(14-21-12-22(32)15-23(33)13-21)29(37)27-16-24(17-34-27)40-19-20-9-7-6-8-10-20/h6-10,12-13,15,24-29,34,37H,3-5,11,14,16-19H2,1-2H3,(H,35,38)/t24-,25+,26-,27-,28+,29-/m1/s1	SOSILAYXEBGSER-XBGOEWRMSA-N	50374238	CHEMBL257433	Beta-secretase 2			 400							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374238&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455543	160853328		CHEMBL257433				ZINC29129268	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861556	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2cccs2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C30H33F2N3O4S/c31-22-9-20(10-23(32)13-22)11-27(29(37)26-14-24(15-33-26)39-18-19-5-2-1-3-6-19)34-30(38)21-12-28(36)35(16-21)17-25-7-4-8-40-25/h1-10,13,21,24,26-27,29,33,37H,11-12,14-18H2,(H,34,38)/t21-,24+,26+,27-,29+/m0/s1	QNAUIQFUNUANGG-YHYSZDIKSA-N	50374228	CHEMBL402754	Beta-secretase 2			 1350							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455567	160853318		CHEMBL402754				ZINC29129347	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861557	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2ccco2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C30H33F2N3O5/c31-22-9-20(10-23(32)13-22)11-27(29(37)26-14-25(15-33-26)40-18-19-5-2-1-3-6-19)34-30(38)21-12-28(36)35(16-21)17-24-7-4-8-39-24/h1-10,13,21,25-27,29,33,37H,11-12,14-18H2,(H,34,38)/t21-,25+,26+,27-,29+/m0/s1	YFSSMGIKETYJOY-CUCBPSOYSA-N	50374239	CHEMBL404682	Beta-secretase 2			 1070							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374239&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455570	160853329		CHEMBL404682				ZINC29129353	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861558	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2cccnc2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C31H34F2N4O4/c32-24-9-22(10-25(33)13-24)11-28(30(39)27-14-26(16-35-27)41-19-20-5-2-1-3-6-20)36-31(40)23-12-29(38)37(18-23)17-21-7-4-8-34-15-21/h1-10,13,15,23,26-28,30,35,39H,11-12,14,16-19H2,(H,36,40)/t23-,26+,27+,28-,30+/m0/s1	IMKXYXBHFRRSCC-PWOSISDISA-N	50374240	CHEMBL270822	Beta-secretase 2			 5600							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374240&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455573	160853330		CHEMBL270822				ZINC29129359	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861559	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2ccccc2F)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C32H34F3N3O4/c33-24-10-21(11-25(34)14-24)12-29(31(40)28-15-26(16-36-28)42-19-20-6-2-1-3-7-20)37-32(41)23-13-30(39)38(18-23)17-22-8-4-5-9-27(22)35/h1-11,14,23,26,28-29,31,36,40H,12-13,15-19H2,(H,37,41)/t23-,26+,28+,29-,31+/m0/s1	MOYZPMYCZRHSLE-AMUPCTJBSA-N	50374241	CHEMBL255602	Beta-secretase 2			 1400							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455601	160853331		CHEMBL255602				ZINC29129439	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861560	Cc1cccc(CN2C[C@H](CC2=O)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@H](CN2)OCc2ccccc2)c1	InChI=1S/C33H37F2N3O4/c1-21-6-5-9-23(10-21)18-38-19-25(14-31(38)39)33(41)37-30(13-24-11-26(34)15-27(35)12-24)32(40)29-16-28(17-36-29)42-20-22-7-3-2-4-8-22/h2-12,15,25,28-30,32,36,40H,13-14,16-20H2,1H3,(H,37,41)/t25-,28+,29+,30-,32+/m0/s1	SHYZDIAEEXDRKD-RYUYIOONSA-N	50374242	CHEMBL402307	Beta-secretase 2			 2150							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374242&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455639	160853332		CHEMBL402307				ZINC29129540	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861561	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2ccc(F)cc2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C32H34F3N3O4/c33-24-8-6-20(7-9-24)17-38-18-23(13-30(38)39)32(41)37-29(12-22-10-25(34)14-26(35)11-22)31(40)28-15-27(16-36-28)42-19-21-4-2-1-3-5-21/h1-11,14,23,27-29,31,36,40H,12-13,15-19H2,(H,37,41)/t23-,27+,28+,29-,31+/m0/s1	OECJCYNBTSNVFN-XVLIYFGKSA-N	50374243	CHEMBL403241	Beta-secretase 2			 5150							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374243&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455666	160853333		CHEMBL403241				ZINC29129612	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861562	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2ccccc2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C32H35F2N3O4/c33-25-11-23(12-26(34)15-25)13-29(31(39)28-16-27(17-35-28)41-20-22-9-5-2-6-10-22)36-32(40)24-14-30(38)37(19-24)18-21-7-3-1-4-8-21/h1-12,15,24,27-29,31,35,39H,13-14,16-20H2,(H,36,40)/t24-,27+,28+,29-,31+/m0/s1	AMAMHDYGHUPWNL-BLEPWVTGSA-N	50374244	CHEMBL271249	Beta-secretase 2			 1700							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374244&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455692	160853334		CHEMBL271249				ZINC29129681	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861563	CCCOCCN1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C30H39F2N3O5/c1-2-9-39-10-8-35-18-22(14-28(35)36)30(38)34-27(13-21-11-23(31)15-24(32)12-21)29(37)26-16-25(17-33-26)40-19-20-6-4-3-5-7-20/h3-7,11-12,15,22,25-27,29,33,37H,2,8-10,13-14,16-19H2,1H3,(H,34,38)/t22-,25+,26+,27-,29+/m0/s1	GECHFZJHIDABEZ-NAWJDLSISA-N	50374229	CHEMBL403850	Beta-secretase 2			 1500							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455691	160853319		CHEMBL403850				ZINC29129680	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861564	CCOCCCN1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C30H39F2N3O5/c1-2-39-10-6-9-35-18-22(14-28(35)36)30(38)34-27(13-21-11-23(31)15-24(32)12-21)29(37)26-16-25(17-33-26)40-19-20-7-4-3-5-8-20/h3-5,7-8,11-12,15,22,25-27,29,33,37H,2,6,9-10,13-14,16-19H2,1H3,(H,34,38)/t22-,25+,26+,27-,29+/m0/s1	HMAQOZURTYPAJX-NAWJDLSISA-N	50374231	CHEMBL428952	Beta-secretase 2			 2000							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374231&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455724	160853321		CHEMBL428952				ZINC29129769	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861565	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(CC2CC2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C29H35F2N3O4/c30-22-8-20(9-23(31)12-22)10-26(33-29(37)21-11-27(35)34(16-21)15-18-6-7-18)28(36)25-13-24(14-32-25)38-17-19-4-2-1-3-5-19/h1-5,8-9,12,18,21,24-26,28,32,36H,6-7,10-11,13-17H2,(H,33,37)/t21-,24+,25+,26-,28+/m0/s1	AVZGOZFFWXGHQU-SZWLPIDJSA-N	50374232	CHEMBL402070	Beta-secretase 2			 795							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374232&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455750	160853322		CHEMBL402070				ZINC29129857	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861566	CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C35H43F2N3O4/c1-4-11-40(12-5-2)35(43)27-14-23(3)13-26(18-27)34(42)39-32(17-25-15-28(36)19-29(37)16-25)33(41)31-20-30(21-38-31)44-22-24-9-7-6-8-10-24/h6-10,13-16,18-19,30-33,38,41H,4-5,11-12,17,20-22H2,1-3H3,(H,39,42)/t30-,31-,32+,33-/m1/s1	GZHSLBYVXGDJDF-NXVJRICRSA-N	50372198	CHEMBL270359	Beta-secretase 2			 45							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50372198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50372198&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CS7	2QMD	11556254	160851299		CHEMBL270359				ZINC16052459	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861567	CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)Oc1ccccc1	InChI=1S/C34H41F2N3O4/c1-4-11-39(12-5-2)34(42)25-14-22(3)13-24(18-25)33(41)38-31(17-23-15-26(35)19-27(36)16-23)32(40)30-20-29(21-37-30)43-28-9-7-6-8-10-28/h6-10,13-16,18-19,29-32,37,40H,4-5,11-12,17,20-21H2,1-3H3,(H,38,41)/t29-,30-,31+,32-/m1/s1	YDCNYSQITCUGST-FEFKUCBWSA-N	50372181	CHEMBL403727	Beta-secretase 2			 54							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50372181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50372181&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	CS9	2QMF	11614083	160851282		CHEMBL403727				ZINC16052458	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861576	CCCCCN1C[C@H]([C@H](CC(C)C)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C34H47F2N3O4/c1-4-5-9-12-39-20-29(28(34(39)42)13-22(2)3)33(41)38-31(16-24-14-25(35)17-26(36)15-24)32(40)30-18-27(19-37-30)43-21-23-10-7-6-8-11-23/h6-8,10-11,14-15,17,22,27-32,37,40H,4-5,9,12-13,16,18-21H2,1-3H3,(H,38,41)/t27-,28+,29-,30-,31+,32-/m1/s1	HZSLONNESJAHNY-IDPSDNDTSA-N	50374222	CHEMBL256679	Beta-secretase 2			 2600							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374222&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455467	160853312		CHEMBL256679				ZINC29129123	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861577	CCCCN1C[C@H]([C@H](Cc2ccccc2)C1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C36H43F2N3O4/c1-2-3-14-41-22-31(30(36(41)44)17-24-10-6-4-7-11-24)35(43)40-33(18-26-15-27(37)19-28(38)16-26)34(42)32-20-29(21-39-32)45-23-25-12-8-5-9-13-25/h4-13,15-16,19,29-34,39,42H,2-3,14,17-18,20-23H2,1H3,(H,40,43)/t29-,30+,31-,32-,33+,34-/m1/s1	SQPZARAMVNZQOD-GIUJWDCDSA-N	50374245	CHEMBL403109	Beta-secretase 2			 1200							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374245&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455516	160853335		CHEMBL403109				ZINC29129209	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861578	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2nccs2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C29H32F2N4O4S/c30-21-8-19(9-22(31)12-21)10-25(28(37)24-13-23(14-33-24)39-17-18-4-2-1-3-5-18)34-29(38)20-11-27(36)35(15-20)16-26-32-6-7-40-26/h1-9,12,20,23-25,28,33,37H,10-11,13-17H2,(H,34,38)/t20-,23+,24+,25-,28+/m0/s1	MHYMQEOZSXVCAM-JGYHPKCFSA-N	50374227	CHEMBL430039	Beta-secretase 2			 6200							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455544	160853317		CHEMBL430039				ZINC29129273	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861579	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2ccccn2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C31H34F2N4O4/c32-23-10-21(11-24(33)14-23)12-28(30(39)27-15-26(16-35-27)41-19-20-6-2-1-3-7-20)36-31(40)22-13-29(38)37(17-22)18-25-8-4-5-9-34-25/h1-11,14,22,26-28,30,35,39H,12-13,15-19H2,(H,36,40)/t22-,26+,27+,28-,30+/m0/s1	GLGMFTLBJXUZQC-DBXUVXQGSA-N	50374250	CHEMBL404839	Beta-secretase 2			 3600							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455602	160853340		CHEMBL404839				ZINC29129441	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861580	O[C@@H]([C@H](Cc1cc(F)cc(F)c1)NC(=O)[C@@H]1CN(Cc2cccc(F)c2)C(=O)C1)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C32H34F3N3O4/c33-24-8-4-7-21(9-24)17-38-18-23(13-30(38)39)32(41)37-29(12-22-10-25(34)14-26(35)11-22)31(40)28-15-27(16-36-28)42-19-20-5-2-1-3-6-20/h1-11,14,23,27-29,31,36,40H,12-13,15-19H2,(H,37,41)/t23-,27+,28+,29-,31+/m0/s1	TWWDDBWWIJXNSA-XVLIYFGKSA-N	50374246	CHEMBL402374	Beta-secretase 2			 2130							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455638	160853336		CHEMBL402374				ZINC29129538	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861581	CCOCCN1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C29H37F2N3O5/c1-2-38-9-8-34-17-21(13-27(34)35)29(37)33-26(12-20-10-22(30)14-23(31)11-20)28(36)25-15-24(16-32-25)39-18-19-6-4-3-5-7-19/h3-7,10-11,14,21,24-26,28,32,36H,2,8-9,12-13,15-18H2,1H3,(H,33,37)/t21-,24+,25+,26-,28+/m0/s1	SGFGBINKHKVLNN-SZWLPIDJSA-N	50374230	CHEMBL401717	Beta-secretase 2			 1200							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374230&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455695	160853320		CHEMBL401717				ZINC29129687	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861582	CCCCCCN1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C31H41F2N3O4/c1-2-3-4-8-11-36-19-23(15-29(36)37)31(39)35-28(14-22-12-24(32)16-25(33)13-22)30(38)27-17-26(18-34-27)40-20-21-9-6-5-7-10-21/h5-7,9-10,12-13,16,23,26-28,30,34,38H,2-4,8,11,14-15,17-20H2,1H3,(H,35,39)/t23-,26+,27+,28-,30+/m0/s1	IKODLZLZNMQHGK-PWOSISDISA-N	50374248	CHEMBL403593	Beta-secretase 2			 582							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455753	160853338		CHEMBL403593				ZINC29129864	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861590	CCCC(CCC)N1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C32H43F2N3O4/c1-3-8-26(9-4-2)37-19-23(15-30(37)38)32(40)36-29(14-22-12-24(33)16-25(34)13-22)31(39)28-17-27(18-35-28)41-20-21-10-6-5-7-11-21/h5-7,10-13,16,23,26-29,31,35,39H,3-4,8-9,14-15,17-20H2,1-2H3,(H,36,40)/t23-,27+,28+,29-,31+/m0/s1	OKPGXAGXHSHEHL-XVLIYFGKSA-N	50374221	CHEMBL255540	Beta-secretase 2			 1200							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455754	160853311		CHEMBL255540				ZINC29129866	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861591	CCCCCN1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C30H39F2N3O4/c1-2-3-7-10-35-18-22(14-28(35)36)30(38)34-27(13-21-11-23(31)15-24(32)12-21)29(37)26-16-25(17-33-26)39-19-20-8-5-4-6-9-20/h4-6,8-9,11-12,15,22,25-27,29,33,37H,2-3,7,10,13-14,16-19H2,1H3,(H,34,38)/t22-,25+,26+,27-,29+/m0/s1	NYPJXBOLQXWFKC-NAWJDLSISA-N	50374233	CHEMBL428870	Beta-secretase 2			 610							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374233&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455772	160853323		CHEMBL428870				ZINC29129942	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861592	CCCCN1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C29H37F2N3O4/c1-2-3-9-34-17-21(13-27(34)35)29(37)33-26(12-20-10-22(30)14-23(31)11-20)28(36)25-15-24(16-32-25)38-18-19-7-5-4-6-8-19/h4-8,10-11,14,21,24-26,28,32,36H,2-3,9,12-13,15-18H2,1H3,(H,33,37)/t21-,24+,25+,26-,28+/m0/s1	MWFQJCIZICLSIJ-SZWLPIDJSA-N	50374234	CHEMBL429505	Beta-secretase 2			 2300							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374234&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455775	160853324		CHEMBL429505				ZINC29129950	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861593	CCCN1C[C@H](CC1=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1	InChI=1S/C28H35F2N3O4/c1-2-8-33-16-20(12-26(33)34)28(36)32-25(11-19-9-21(29)13-22(30)10-19)27(35)24-14-23(15-31-24)37-17-18-6-4-3-5-7-18/h3-7,9-10,13,20,23-25,27,31,35H,2,8,11-12,14-17H2,1H3,(H,32,36)/t20-,23+,24+,25-,27+/m0/s1	WDMHJLIMBHMWJK-XXKHLWARSA-N	50374235	CHEMBL258351	Beta-secretase 2			 5000							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44455802	160853325		CHEMBL258351				ZINC29130025	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50861596	COC[C@H]1CCCN1C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)Oc1ccccc1	InChI=1S/C34H39F2N3O5/c1-21-11-23(16-24(12-21)34(42)39-10-6-7-27(39)20-43-2)33(41)38-31(15-22-13-25(35)17-26(36)14-22)32(40)30-18-29(19-37-30)44-28-8-4-3-5-9-28/h3-5,8-9,11-14,16-17,27,29-32,37,40H,6-7,10,15,18-20H2,1-2H3,(H,38,41)/t27-,29-,30-,31+,32-/m1/s1	KYHYNSQLYDXSNK-MXWGZHRFSA-N	50374253	CHEMBL403195	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2007.10.053	10.7270/Q2P84CRH	17980584			Iserloh, U; Pan, J; Stamford, AW; Kennedy, ME; Zhang, Q; Zhang, L; Parker, EM; McHugh, NA; Favreau, L; Strickland, C; Voigt, J	Schering-Plough Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	SC6	2QMG	11578047	160853343		CHEMBL403195				ZINC14209296	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909453	CN1C(N)=NC(C1=O)(c1cccc(c1)-c1cncnc1)c1cc(C)nc(C)c1	InChI=1S/C21H20N6O/c1-13-7-18(8-14(2)25-13)21(19(28)27(3)20(22)26-21)17-6-4-5-15(9-17)16-10-23-12-24-11-16/h4-12H,1-3H3,(H2,22,26)	AZEJJBDMXZISKY-UHFFFAOYSA-N	50310151	CHEMBL597062::rac-2-amino-4-(2,6-dimethylpyridin-4-yl)-1-methyl-4-(3-(pyrimidin-5-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 24100							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310151&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950662	104144512		CHEMBL597062				ZINC34804852	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909454	CCc1cc(cc(CC)n1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C23H24N6O/c1-4-19-10-18(11-20(5-2)27-19)23(21(30)29(3)22(24)28-23)17-8-6-7-15(9-17)16-12-25-14-26-13-16/h6-14H,4-5H2,1-3H3,(H2,24,28)	QQPRKWVAAAEILV-UHFFFAOYSA-N	50310152	CHEMBL597277::rac-2-amino-4-(2,6-diethylpyridin-4-yl)-1-methyl-4-(3-(pyrimidin-5-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 23600							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310152&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	BX2	3IN4	46231500	104144513		CHEMBL597277				ZINC45355320	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909455	CCc1cc(cc(CC)n1)[C@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C23H24N6O/c1-4-19-10-18(11-20(5-2)27-19)23(21(30)29(3)22(24)28-23)17-8-6-7-15(9-17)16-12-25-14-26-13-16/h6-14H,4-5H2,1-3H3,(H2,24,28)/t23-/m1/s1	QQPRKWVAAAEILV-HSZRJFAPSA-N	50310153	(R)-2-amino-4-(2,6-diethylpyridin-4-yl)-1-methyl-4-(3-(pyrimidin-5-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL598289	Beta-secretase 2			 11000							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310153&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46231554	104144514		CHEMBL598289					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909456	CCc1cc(cc(CC)n1)[C@@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C24H24FN5O/c1-4-18-13-17(14-19(5-2)28-18)24(22(31)30(3)23(26)29-24)16-9-6-8-15(12-16)20-10-7-11-27-21(20)25/h6-14H,4-5H2,1-3H3,(H2,26,29)/t24-/m0/s1	FWLPFLWMHMGKPS-DEOSSOPVSA-N	50310150	(S)-2-amino-4-(2,6-diethylpyridin-4-yl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL598290	Beta-secretase 2			 6700							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310150&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46231555	104144511		CHEMBL598290				ZINC45355323	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909481	NC1=NC(C2=NCCCN12)(c1ccccc1)c1ccccc1	InChI=1S/C18H18N4/c19-17-21-18(14-8-3-1-4-9-14,15-10-5-2-6-11-15)16-20-12-7-13-22(16)17/h1-6,8-11H,7,12-13H2,(H2,19,21)	UFWSJOVQEPTPNE-UHFFFAOYSA-N	50300710	8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL582044	Beta-secretase 2			 38300							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	454	3IGB	11543843	104155071		CHEMBL582044				ZINC34657615	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909482	CN1C(N)=NC(C1=O)(c1ccccc1)c1ccccc1	InChI=1S/C16H15N3O/c1-19-14(20)16(18-15(19)17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11H,1H3,(H2,17,18)	RNWLAFWLSSMCLN-UHFFFAOYSA-N	50300229	1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine::2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one::2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-one::5,5-Diphenyl-2-iminohydantoin::CHEMBL291784	Beta-secretase 2			 770							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15054176	104154590		CHEMBL291784				ZINC29544241	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909483	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F	InChI=1S/C23H21FN4O2/c1-14-12-17(9-10-19(14)30-3)23(21(29)28(2)22(25)27-23)16-7-4-6-15(13-16)18-8-5-11-26-20(18)24/h4-13H,1-3H3,(H2,25,27)	FZVZGKTWGPYMHW-UHFFFAOYSA-N	50303717	2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL566011::rac-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one	Beta-secretase 2			 780							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303717&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45488119	104158078		CHEMBL566011				ZINC45246053	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909484	COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C23H22N4O2/c1-15-12-19(9-10-20(15)29-3)23(21(28)27(2)22(24)26-23)18-8-4-6-16(13-18)17-7-5-11-25-14-17/h4-14H,1-3H3,(H2,24,26)	TWVGNKMRZLBNOD-UHFFFAOYSA-N	50303719	2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566200::rac-2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 790							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303719&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	X45	3INF	11516577	104158080		CHEMBL566200				ZINC45245214	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909485	CN1C(N)=NC(C1=O)(c1ccccc1)c1ccncc1	InChI=1S/C15H14N4O/c1-19-13(20)15(18-14(19)16,11-5-3-2-4-6-11)12-7-9-17-10-8-12/h2-10H,1H3,(H2,16,18)	IMGNUVBMHZZYCN-UHFFFAOYSA-N	50310154	2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL597233::rac-2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 2010							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310154&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951413	104144515		CHEMBL597233				ZINC34806279	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909486	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1ccccc1	InChI=1S/C21H18N4O/c1-25-19(26)21(24-20(25)22,17-10-12-23-13-11-17)18-9-5-8-16(14-18)15-6-3-2-4-7-15/h2-14H,1H3,(H2,22,24)	RDWGKVFCNRXSNW-UHFFFAOYSA-N	50310149	2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL598876::rac-2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 140							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310149&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15951416	104144510		CHEMBL598876				ZINC34806291	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909487	CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cccnc1	InChI=1S/C20H17N5O/c1-25-18(26)20(24-19(25)21,16-7-10-22-11-8-16)17-6-2-4-14(12-17)15-5-3-9-23-13-15/h2-13H,1H3,(H2,21,24)	AIKOTXHNUIYVMD-UHFFFAOYSA-N	50310155	2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL604590::rac-2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 480							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310155&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	472	3IN3	15950666	104144516		CHEMBL604590				ZINC34804868	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909488	CN1C(N)=NC(C1=O)(c1cccc(c1)-c1cccnc1)c1ccnc(C)c1	InChI=1S/C21H19N5O/c1-14-11-18(8-10-24-14)21(19(27)26(2)20(22)25-21)17-7-3-5-15(12-17)16-6-4-9-23-13-16/h3-13H,1-2H3,(H2,22,25)	DCYJRONKTIQNEU-UHFFFAOYSA-N	50310156	CHEMBL598257::rac-2-amino-1-methyl-4-(2-methylpyridin-4-yl)-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 1170							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310156&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950595	104144517		CHEMBL598257				ZINC34804730	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909489	CN1C(N)=NC(C1=O)(c1cccc(c1)-c1cncnc1)c1ccnc(C)c1	InChI=1S/C20H18N6O/c1-13-8-17(6-7-24-13)20(18(27)26(2)19(21)25-20)16-5-3-4-14(9-16)15-10-22-12-23-11-15/h3-12H,1-2H3,(H2,21,25)	WVICKDVVFIIGRI-UHFFFAOYSA-N	50310157	CHEMBL598258::rac-2-amino-1-methyl-4-(2-methylpyridin-4-yl)-4-(3-(pyrimidin-5-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 2200							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310157&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950667	104144518		CHEMBL598258				ZINC34804871	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909490	CCc1cc(ccn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C21H20N6O/c1-3-18-10-17(7-8-25-18)21(19(28)27(2)20(22)26-21)16-6-4-5-14(9-16)15-11-23-13-24-12-15/h4-13H,3H2,1-2H3,(H2,22,26)	INKNZABLNYYGBD-UHFFFAOYSA-N	50310158	CHEMBL598259::rac-2-amino-4-(2-ethylpyridin-4-yl)-1-methyl-4-(3-(pyrimidin-5-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 1020							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310158&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			15950597	104144519		CHEMBL598259				ZINC34804739	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909491	CC(C)c1cc(ccn1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1	InChI=1S/C22H22N6O/c1-14(2)19-10-18(7-8-26-19)22(20(29)28(3)21(23)27-22)17-6-4-5-15(9-17)16-11-24-13-25-12-16/h4-14H,1-3H3,(H2,23,27)	WEPVSZQVQNITEF-UHFFFAOYSA-N	50310159	CHEMBL590492::rac-2-amino-4-(2-isopropylpyridin-4-yl)-1-methyl-4-(3-(pyrimidin-5-yl)phenyl)-1H-imidazol-5(4H)-one	Beta-secretase 2			 6130							ChEMBL	10.1016/j.bmc.2009.12.007	10.7270/Q2DV1KT4	20045648			Malamas, MS; Barnes, K; Johnson, M; Hui, Y; Zhou, P; Turner, J; Hu, Y; Wagner, E; Fan, K; Chopra, R; Olland, A; Bard, J; Pangalos, M; Reinhart, P; Robichaud, AJ	Wyeth Research	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310159&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46231497	104144520		CHEMBL590492				ZINC45336921	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916115	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1cc(Cl)cc(Cl)c1)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C33H40Cl2N4O5S/c1-22(32(41)37-27-13-7-4-8-14-27)36-21-31(40)30(16-23-10-5-3-6-11-23)38-33(42)24-12-9-15-28(17-24)39(45(2,43)44)29-19-25(34)18-26(35)20-29/h3,5-6,9-12,15,17-20,22,27,30-31,36,40H,4,7-8,13-14,16,21H2,1-2H3,(H,37,41)(H,38,42)/t22-,30-,31+/m0/s1	ZDEXTHTTXHQRPJ-TZJDENGASA-N	50322914	CHEMBL1210349::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-(3,5-dichlorophenyl)methylsulfonamido)benzamide	Beta-secretase 2			 430							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322914&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10258985	117644235		CHEMBL1210349				ZINC58614547	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916117	CS(=O)(=O)N(c1ccccc1)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O	InChI=1S/C36H37F3N4O5S/c1-49(47,48)43(29-14-6-3-7-15-29)31-21-27(20-30(22-31)42-17-9-16-34(42)45)35(46)41-32(19-25-10-4-2-5-11-25)33(44)24-40-23-26-12-8-13-28(18-26)36(37,38)39/h2-8,10-15,18,20-22,32-33,40,44H,9,16-17,19,23-24H2,1H3,(H,41,46)/t32-,33+/m0/s1	OCHDDAGWDCOFQM-JHOUSYSJSA-N	50322886	CHEMBL1210363::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(2-oxopyrrolidin-1-yl)-5-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 145							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322886&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10439665	117644207		CHEMBL1210363				ZINC58655449	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916120	CCS(=O)(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N(c1ccccc1)S(C)(=O)=O	InChI=1S/C34H36F3N3O6S2/c1-3-48(45,46)30-20-26(19-29(21-30)40(47(2,43)44)28-15-8-5-9-16-28)33(42)39-31(18-24-11-6-4-7-12-24)32(41)23-38-22-25-13-10-14-27(17-25)34(35,36)37/h4-17,19-21,31-32,38,41H,3,18,22-23H2,1-2H3,(H,39,42)/t31-,32+/m0/s1	JDPTZHWBCXFTAC-AJQTZOPKSA-N	50322915	3-(ethylsulfonyl)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)benzamide::CHEMBL1210364	Beta-secretase 2			 1510							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322915&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11765311	117644236		CHEMBL1210364				ZINC58468457	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916137	CS(=O)(=O)N(c1ccccc1)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)C1CCCC1	InChI=1S/C37H40F3N3O4S/c1-48(46,47)43(32-17-6-3-7-18-32)33-22-29(28-14-8-9-15-28)21-30(23-33)36(45)42-34(20-26-11-4-2-5-12-26)35(44)25-41-24-27-13-10-16-31(19-27)37(38,39)40/h2-7,10-13,16-19,21-23,28,34-35,41,44H,8-9,14-15,20,24-25H2,1H3,(H,42,45)/t34-,35+/m0/s1	HGSCTPUCDDAAQZ-OIDHKYIRSA-N	50322916	3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)benzamide::CHEMBL1210434	Beta-secretase 2			 42							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322916&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10327211	117644237		CHEMBL1210434				ZINC03987498	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916148	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1ccc(cc1)C#N)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C34H41N5O5S/c1-24(33(41)37-28-13-7-4-8-14-28)36-23-32(40)31(20-25-10-5-3-6-11-25)38-34(42)27-12-9-15-30(21-27)39(45(2,43)44)29-18-16-26(22-35)17-19-29/h3,5-6,9-12,15-19,21,24,28,31-32,36,40H,4,7-8,13-14,20,23H2,1-2H3,(H,37,41)(H,38,42)/t24-,31-,32+/m0/s1	OUJNBZOVRLESMB-JPBRBXQBSA-N	50322887	3-(N-(4-cyanophenyl)methylsulfonamido)-N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)benzamide::CHEMBL1210348	Beta-secretase 2			 4215							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322887&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10077756	117644208		CHEMBL1210348				ZINC58602946	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916151	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1ccc(Cl)cc1)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C33H41ClN4O5S/c1-23(32(40)36-27-13-7-4-8-14-27)35-22-31(39)30(20-24-10-5-3-6-11-24)37-33(41)25-12-9-15-29(21-25)38(44(2,42)43)28-18-16-26(34)17-19-28/h3,5-6,9-12,15-19,21,23,27,30-31,35,39H,4,7-8,13-14,20,22H2,1-2H3,(H,36,40)(H,37,41)/t23-,30-,31+/m0/s1	FPRUVWLYPRNZSM-IZDARVJKSA-N	50322888	3-(N-(4-chlorophenyl)methylsulfonamido)-N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)benzamide::CHEMBL1210347	Beta-secretase 2			 420							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322888&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10054920	117644209		CHEMBL1210347				ZINC58468479	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916154	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1ccc(cc1)C(F)(F)F)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C34H41F3N4O5S/c1-23(32(43)39-27-13-7-4-8-14-27)38-22-31(42)30(20-24-10-5-3-6-11-24)40-33(44)25-12-9-15-29(21-25)41(47(2,45)46)28-18-16-26(17-19-28)34(35,36)37/h3,5-6,9-12,15-19,21,23,27,30-31,38,42H,4,7-8,13-14,20,22H2,1-2H3,(H,39,43)(H,40,44)/t23-,30-,31+/m0/s1	JNYDNVYRYGLEFM-IZDARVJKSA-N	50322889	CHEMBL1210346::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-(4-(trifluoromethyl)phenyl)methylsulfonamido)benzamide	Beta-secretase 2			 690							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322889&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11765081	117644210		CHEMBL1210346				ZINC58598756	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916157	COc1ccc(cc1)N(c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)S(C)(=O)=O	InChI=1S/C34H44N4O6S/c1-24(33(40)36-27-14-8-5-9-15-27)35-23-32(39)31(21-25-11-6-4-7-12-25)37-34(41)26-13-10-16-29(22-26)38(45(3,42)43)28-17-19-30(44-2)20-18-28/h4,6-7,10-13,16-20,22,24,27,31-32,35,39H,5,8-9,14-15,21,23H2,1-3H3,(H,36,40)(H,37,41)/t24-,31-,32+/m0/s1	WZNIQJLAQZGRNG-JPBRBXQBSA-N	50322890	CHEMBL1210345::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-(4-methoxyphenyl)methylsulfonamido)benzamide	Beta-secretase 2			 435							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322890&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10077830	117644211		CHEMBL1210345				ZINC58583585	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916160	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1cccc(c1)C#N)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C34H41N5O5S/c1-24(33(41)37-28-15-7-4-8-16-28)36-23-32(40)31(20-25-11-5-3-6-12-25)38-34(42)27-14-10-18-30(21-27)39(45(2,43)44)29-17-9-13-26(19-29)22-35/h3,5-6,9-14,17-19,21,24,28,31-32,36,40H,4,7-8,15-16,20,23H2,1-2H3,(H,37,41)(H,38,42)/t24-,31-,32+/m0/s1	KHMCHMYWEFEWGH-JPBRBXQBSA-N	50322891	3-(N-(3-cyanophenyl)methylsulfonamido)-N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)benzamide::CHEMBL1210344	Beta-secretase 2			 510							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322891&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10371854	117644212		CHEMBL1210344				ZINC58638886	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916163	COc1cccc(c1)N(c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)S(C)(=O)=O	InChI=1S/C34H44N4O6S/c1-24(33(40)36-27-15-8-5-9-16-27)35-23-32(39)31(20-25-12-6-4-7-13-25)37-34(41)26-14-10-17-28(21-26)38(45(3,42)43)29-18-11-19-30(22-29)44-2/h4,6-7,10-14,17-19,21-22,24,27,31-32,35,39H,5,8-9,15-16,20,23H2,1-3H3,(H,36,40)(H,37,41)/t24-,31-,32+/m0/s1	FRUZRFQTENRJJT-JPBRBXQBSA-N	50322892	CHEMBL1210343::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-(3-methoxyphenyl)methylsulfonamido)benzamide	Beta-secretase 2			 765							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322892&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10461757	117644213		CHEMBL1210343				ZINC58581804	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916166	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1ccccc1C#N)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C34H41N5O5S/c1-24(33(41)37-28-16-7-4-8-17-28)36-23-32(40)30(20-25-12-5-3-6-13-25)38-34(42)26-15-11-18-29(21-26)39(45(2,43)44)31-19-10-9-14-27(31)22-35/h3,5-6,9-15,18-19,21,24,28,30,32,36,40H,4,7-8,16-17,20,23H2,1-2H3,(H,37,41)(H,38,42)/t24-,30-,32+/m0/s1	HVUSENQTTSYTSM-WJIXKWODSA-N	50322893	3-(N-(2-cyanophenyl)methylsulfonamido)-N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)benzamide::CHEMBL1210342	Beta-secretase 2			 10110							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322893&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			9986500	117644214		CHEMBL1210342				ZINC58594237	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916169	COc1ccccc1N(c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)S(C)(=O)=O	InChI=1S/C34H44N4O6S/c1-24(33(40)36-27-16-8-5-9-17-27)35-23-31(39)29(21-25-13-6-4-7-14-25)37-34(41)26-15-12-18-28(22-26)38(45(3,42)43)30-19-10-11-20-32(30)44-2/h4,6-7,10-15,18-20,22,24,27,29,31,35,39H,5,8-9,16-17,21,23H2,1-3H3,(H,36,40)(H,37,41)/t24-,29-,31+/m0/s1	LWYYRFSTHDYJTQ-YKZUFBCQSA-N	50322894	CHEMBL1210341::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-(2-methoxyphenyl)methylsulfonamido)benzamide	Beta-secretase 2			 3615							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322894&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10258545	117644215		CHEMBL1210341				ZINC58468462	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916172	CS(=O)(=O)N(c1ccccc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C32H32F3N3O4S/c1-43(41,42)38(27-15-6-3-7-16-27)28-17-9-13-25(20-28)31(40)37-29(19-23-10-4-2-5-11-23)30(39)22-36-21-24-12-8-14-26(18-24)32(33,34)35/h2-18,20,29-30,36,39H,19,21-22H2,1H3,(H,37,40)/t29-,30+/m0/s1	VACCKGGBGSUGJZ-XZWHSSHBSA-N	50322895	CHEMBL1210340::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 870							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322895&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10100288	117644216		CHEMBL1210340				ZINC58581801	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916175	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)S(=O)(=O)N(C)Cc1ccccc1)C(=O)NC1CCCCC1	InChI=1S/C34H44N4O5S/c1-25(33(40)36-29-18-10-5-11-19-29)35-23-32(39)31(21-26-13-6-3-7-14-26)37-34(41)28-17-12-20-30(22-28)44(42,43)38(2)24-27-15-8-4-9-16-27/h3-4,6-9,12-17,20,22,25,29,31-32,35,39H,5,10-11,18-19,21,23-24H2,1-2H3,(H,36,40)(H,37,41)/t25-,31-,32+/m0/s1	HRCZMIYCTNBPAO-FWGANANOSA-N	50322896	3-(N-benzyl-N-methylsulfamoyl)-N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)benzamide::CHEMBL1210339	Beta-secretase 2			 200000							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322896&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863030	117644217		CHEMBL1210339				ZINC58581797	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916178	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)S(=O)(=O)Cc1ccccc1)C(=O)NC1CCCCC1	InChI=1S/C33H41N3O5S/c1-24(32(38)35-28-17-9-4-10-18-28)34-22-31(37)30(20-25-12-5-2-6-13-25)36-33(39)27-16-11-19-29(21-27)42(40,41)23-26-14-7-3-8-15-26/h2-3,5-8,11-16,19,21,24,28,30-31,34,37H,4,9-10,17-18,20,22-23H2,1H3,(H,35,38)(H,36,39)/t24-,30-,31+/m0/s1	AFGVBPYOFPPOQR-RJSONGRPSA-N	50322897	3-(benzylsulfonyl)-N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)benzamide::CHEMBL1210338	Beta-secretase 2			 117000							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322897&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863029	117644218		CHEMBL1210338				ZINC58594232	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916181	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(CS(=O)(=O)c2ccccc2)c1)C(=O)NC1CCCCC1	InChI=1S/C33H41N3O5S/c1-24(32(38)35-28-16-7-3-8-17-28)34-22-31(37)30(21-25-12-5-2-6-13-25)36-33(39)27-15-11-14-26(20-27)23-42(40,41)29-18-9-4-10-19-29/h2,4-6,9-15,18-20,24,28,30-31,34,37H,3,7-8,16-17,21-23H2,1H3,(H,35,38)(H,36,39)/t24-,30-,31+/m0/s1	YFNHYENPPGZMJV-RJSONGRPSA-N	50322898	CHEMBL1210337::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(phenylsulfonylmethyl)benzamide	Beta-secretase 2			 46000							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322898&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863028	117644219		CHEMBL1210337				ZINC58582061	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916184	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(OS(=O)(=O)Cc2ccccc2)c1)C(=O)NC1CCCCC1	InChI=1S/C33H41N3O6S/c1-24(32(38)35-28-17-9-4-10-18-28)34-22-31(37)30(20-25-12-5-2-6-13-25)36-33(39)27-16-11-19-29(21-27)42-43(40,41)23-26-14-7-3-8-15-26/h2-3,5-8,11-16,19,21,24,28,30-31,34,37H,4,9-10,17-18,20,22-23H2,1H3,(H,35,38)(H,36,39)/t24-,30-,31+/m0/s1	NWJNHJWSZAHOBB-RJSONGRPSA-N	50322899	3-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)phenyl phenylmethanesulfonate::CHEMBL1210336	Beta-secretase 2			 35000							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322899&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863027	117644220		CHEMBL1210336				ZINC58468460	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916187	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(NS(=O)(=O)Cc2ccccc2)c1)C(=O)NC1CCCCC1	InChI=1S/C33H42N4O5S/c1-24(32(39)35-28-17-9-4-10-18-28)34-22-31(38)30(20-25-12-5-2-6-13-25)36-33(40)27-16-11-19-29(21-27)37-43(41,42)23-26-14-7-3-8-15-26/h2-3,5-8,11-16,19,21,24,28,30-31,34,37-38H,4,9-10,17-18,20,22-23H2,1H3,(H,35,39)(H,36,40)/t24-,30-,31+/m0/s1	AAEYBQRVLJBANX-RJSONGRPSA-N	50322900	CHEMBL1210335::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(phenylmethylsulfonamido)benzamide	Beta-secretase 2			 132000							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322900&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863026	117644221		CHEMBL1210335				ZINC58651317	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916190	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(NS(=O)(=O)c2ccccc2)c1)C(=O)NC1CCCCC1	InChI=1S/C32H40N4O5S/c1-23(31(38)34-26-15-7-3-8-16-26)33-22-30(37)29(20-24-12-5-2-6-13-24)35-32(39)25-14-11-17-27(21-25)36-42(40,41)28-18-9-4-10-19-28/h2,4-6,9-14,17-19,21,23,26,29-30,33,36-37H,3,7-8,15-16,20,22H2,1H3,(H,34,38)(H,35,39)/t23-,29-,30+/m0/s1	FSQREXFFFRKDCI-KEPSJGTLSA-N	50322901	CHEMBL1210334::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(phenylsulfonamido)benzamide	Beta-secretase 2			 79400							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322901&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863025	117644222		CHEMBL1210334				ZINC58594229	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916193	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(Cc1ccccc1)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C34H44N4O5S/c1-25(33(40)36-29-18-10-5-11-19-29)35-23-32(39)31(21-26-13-6-3-7-14-26)37-34(41)28-17-12-20-30(22-28)38(44(2,42)43)24-27-15-8-4-9-16-27/h3-4,6-9,12-17,20,22,25,29,31-32,35,39H,5,10-11,18-19,21,23-24H2,1-2H3,(H,36,40)(H,37,41)/t25-,31-,32+/m0/s1	YLWBAAGWRILMKX-FWGANANOSA-N	50322902	3-(N-benzylmethylsulfonamido)-N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)benzamide::CHEMBL1210333	Beta-secretase 2			 4100							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322902&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863024	117644223		CHEMBL1210333				ZINC58581527	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916196	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(C1CCCCC1)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C33H48N4O5S/c1-24(32(39)35-27-16-8-4-9-17-27)34-23-31(38)30(21-25-13-6-3-7-14-25)36-33(40)26-15-12-20-29(22-26)37(43(2,41)42)28-18-10-5-11-19-28/h3,6-7,12-15,20,22,24,27-28,30-31,34,38H,4-5,8-11,16-19,21,23H2,1-2H3,(H,35,39)(H,36,40)/t24-,30-,31+/m0/s1	QICXKWLEAQCSEK-RJSONGRPSA-N	50322903	CHEMBL1210332::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-cyclohexylmethylsulfonamido)benzamide	Beta-secretase 2			 7100							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322903&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863023	117644224		CHEMBL1210332				ZINC58581525	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916199	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(C(C)=O)c1ccccc1)C(=O)NC1CCCCC1	InChI=1S/C34H42N4O4/c1-24(33(41)36-28-16-8-4-9-17-28)35-23-32(40)31(21-26-13-6-3-7-14-26)37-34(42)27-15-12-20-30(22-27)38(25(2)39)29-18-10-5-11-19-29/h3,5-7,10-15,18-20,22,24,28,31-32,35,40H,4,8-9,16-17,21,23H2,1-2H3,(H,36,41)(H,37,42)/t24-,31-,32+/m0/s1	ILNUAJPKWXVLNB-JPBRBXQBSA-N	50322904	CHEMBL1210331::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-phenylacetamido)benzamide	Beta-secretase 2			 8900							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322904&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863022	117644225		CHEMBL1210331				ZINC58603093	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916202	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(Nc2ccccc2)c1)C(=O)NC1CCCCC1	InChI=1S/C32H40N4O3/c1-23(31(38)35-27-17-9-4-10-18-27)33-22-30(37)29(20-24-12-5-2-6-13-24)36-32(39)25-14-11-19-28(21-25)34-26-15-7-3-8-16-26/h2-3,5-8,11-16,19,21,23,27,29-30,33-34,37H,4,9-10,17-18,20,22H2,1H3,(H,35,38)(H,36,39)/t23-,29-,30+/m0/s1	IQTBSLHTGJXWLW-KEPSJGTLSA-N	50322876	CHEMBL1210330::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(phenylamino)benzamide	Beta-secretase 2			 600							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322876&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863021	117644197		CHEMBL1210330				ZINC58538259	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916205	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1ccccc1)S(C)(=O)=O)C(=O)NC1CCCCC1	InChI=1S/C33H42N4O5S/c1-24(32(39)35-27-16-8-4-9-17-27)34-23-31(38)30(21-25-13-6-3-7-14-25)36-33(40)26-15-12-20-29(22-26)37(43(2,41)42)28-18-10-5-11-19-28/h3,5-7,10-15,18-20,22,24,27,30-31,34,38H,4,8-9,16-17,21,23H2,1-2H3,(H,35,39)(H,36,40)/t24-,30-,31+/m0/s1	PSSKPAZTPVDDNS-RJSONGRPSA-N	50322877	CHEMBL1210329::N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-( PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 655							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	XFI	2XFI	10416248	117644198		CHEMBL1210329				ZINC58603088	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916208	C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N1CCCC1=O)C(=O)NC1CCCCC1	InChI=1S/C30H40N4O4/c1-21(29(37)32-24-13-6-3-7-14-24)31-20-27(35)26(18-22-10-4-2-5-11-22)33-30(38)23-12-8-15-25(19-23)34-17-9-16-28(34)36/h2,4-5,8,10-12,15,19,21,24,26-27,31,35H,3,6-7,9,13-14,16-18,20H2,1H3,(H,32,37)(H,33,38)/t21-,26-,27+/m0/s1	NUXXROATVMQIKI-NJTBCWBZSA-N	50322878	CHEMBL271230::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 79000							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322878&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44454541	117644199		CHEMBL271230				ZINC29127647	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916211	CC(C)CCCC(C)NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N(c1ccccc1)S(C)(=O)=O	InChI=1S/C32H43N3O4S/c1-24(2)13-11-14-25(3)33-23-31(36)30(21-26-15-7-5-8-16-26)34-32(37)27-17-12-20-29(22-27)35(40(4,38)39)28-18-9-6-10-19-28/h5-10,12,15-20,22,24-25,30-31,33,36H,11,13-14,21,23H2,1-4H3,(H,34,37)/t25?,30-,31+/m0/s1	HUCKKBDXVQDXSC-DFCNTKNDSA-N	50322879	CHEMBL1210431::N-((2S,3R)-3-hydroxy-4-(6-methylheptan-2-ylamino)-1-phenylbutan-2-yl)-3-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 780							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322879&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10483879	117644200		CHEMBL1210431				ZINC64245766	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916214	CS(=O)(=O)N(c1ccccc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CCCCC1	InChI=1S/C30H37N3O4S/c1-38(36,37)33(26-17-9-4-10-18-26)27-19-11-14-24(21-27)30(35)32-28(20-23-12-5-2-6-13-23)29(34)22-31-25-15-7-3-8-16-25/h2,4-6,9-14,17-19,21,25,28-29,31,34H,3,7-8,15-16,20,22H2,1H3,(H,32,35)/t28-,29+/m0/s1	FEOZKBJQAROHID-URLMMPGGSA-N	50322880	CHEMBL1210432::N-((2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 3243							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322880&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10098656	117644201		CHEMBL1210432				ZINC58608324	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916217	CS(=O)(=O)N(c1ccccc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1	InChI=1S/C27H31N3O4S/c1-35(33,34)30(23-12-6-3-7-13-23)24-14-8-11-21(18-24)27(32)29-25(17-20-9-4-2-5-10-20)26(31)19-28-22-15-16-22/h2-14,18,22,25-26,28,31H,15-17,19H2,1H3,(H,29,32)/t25-,26+/m0/s1	XVLOVTVVPKSUGV-IZZNHLLZSA-N	50322881	CHEMBL1210433::N-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 12020							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322881&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10413386	117644202		CHEMBL1210433				ZINC38803870	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916220	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N1CCCC1=O	InChI=1S/C32H45N5O4/c1-3-33-26-18-24(19-27(20-26)37-16-10-15-30(37)39)32(41)36-28(17-23-11-6-4-7-12-23)29(38)21-34-22(2)31(40)35-25-13-8-5-9-14-25/h4,6-7,11-12,18-20,22,25,28-29,33-34,38H,3,5,8-10,13-17,21H2,1-2H3,(H,35,40)(H,36,41)/t22-,28-,29+/m0/s1	ARWMRRUIIHCDKG-PWUSVURUSA-N	50231682	CHEMBL251862::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Beta-secretase 2			 1810							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231682	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231682&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	VG5	2XFJ,2VJ6	24882338	104055249		CHEMBL251862				ZINC28978361	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916223	CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)N(c1ccccc1)S(C)(=O)=O	InChI=1S/C35H47N5O5S/c1-4-36-29-21-27(22-31(23-29)40(46(3,44)45)30-18-12-7-13-19-30)35(43)39-32(20-26-14-8-5-9-15-26)33(41)24-37-25(2)34(42)38-28-16-10-6-11-17-28/h5,7-9,12-15,18-19,21-23,25,28,32-33,36-37,41H,4,6,10-11,16-17,20,24H2,1-3H3,(H,38,42)(H,39,43)/t25-,32-,33+/m0/s1	SMMANAWVXZZNER-DZMJNENTSA-N	50322882	CHEMBL1210359::N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1--METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-((METHYLSULFONYL)(PHENYL)AMINO)BENZAMIDE::N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 170							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322882&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	AA9	2XFK	9939419	117644203		CHEMBL1210359				ZINC03987493	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916226	CCOc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N(c1ccccc1)S(C)(=O)=O	InChI=1S/C34H36F3N3O5S/c1-3-45-30-20-26(19-29(21-30)40(46(2,43)44)28-15-8-5-9-16-28)33(42)39-31(18-24-11-6-4-7-12-24)32(41)23-38-22-25-13-10-14-27(17-25)34(35,36)37/h4-17,19-21,31-32,38,41H,3,18,22-23H2,1-2H3,(H,39,42)/t31-,32+/m0/s1	JKURHCLTNUAEBX-AJQTZOPKSA-N	50322883	3-ethoxy-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)benzamide::CHEMBL1210360	Beta-secretase 2			 160							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322883&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10078059	117644204		CHEMBL1210360				ZINC03987503	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916229	CC(C)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N(c1ccccc1)S(C)(=O)=O	InChI=1S/C35H38F3N3O4S/c1-24(2)27-19-28(21-31(20-27)41(46(3,44)45)30-15-8-5-9-16-30)34(43)40-32(18-25-11-6-4-7-12-25)33(42)23-39-22-26-13-10-14-29(17-26)35(36,37)38/h4-17,19-21,24,32-33,39,42H,18,22-23H2,1-3H3,(H,40,43)/t32-,33+/m0/s1	IZGCSYKADOJJHC-JHOUSYSJSA-N	50322884	CHEMBL1210361::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-isopropyl-5-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 580							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322884&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10326962	117644205		CHEMBL1210361				ZINC03987507	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916232	CS(=O)(=O)N(c1ccccc1)c1cc(cc(c1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C38H36F3N3O4S/c1-49(47,48)44(33-18-9-4-10-19-33)34-23-30(29-15-7-3-8-16-29)22-31(24-34)37(46)43-35(21-27-12-5-2-6-13-27)36(45)26-42-25-28-14-11-17-32(20-28)38(39,40)41/h2-20,22-24,35-36,42,45H,21,25-26H2,1H3,(H,43,46)/t35-,36+/m0/s1	VKICSHONDTWPQK-MPQUPPDSSA-N	50322885	CHEMBL1210362::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-5-(N-phenylmethylsulfonamido)biphenyl-3-carboxamide	Beta-secretase 2			 68							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322885&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11765192	117644206		CHEMBL1210362				ZINC58602700	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916245	Cc1ccc(cc1C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N(c1ccccc1)S(C)(=O)=O	InChI=1S/C33H34F3N3O4S/c1-23-16-17-28(39(44(2,42)43)27-14-7-4-8-15-27)20-29(23)32(41)38-30(19-24-10-5-3-6-11-24)31(40)22-37-21-25-12-9-13-26(18-25)33(34,35)36/h3-18,20,30-31,37,40H,19,21-22H2,1-2H3,(H,38,41)/t30-,31+/m0/s1	OWKVOSMRWHCUBA-IOWSJCHKSA-N	50322908	CHEMBL1210356::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-2-methyl-5-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 24550							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322908&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10484078	117644229		CHEMBL1210356				ZINC58468485	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916248	Cc1ccc(cc1N(c1ccccc1)S(C)(=O)=O)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C33H34F3N3O4S/c1-23-16-17-26(20-30(23)39(44(2,42)43)28-14-7-4-8-15-28)32(41)38-29(19-24-10-5-3-6-11-24)31(40)22-37-21-25-12-9-13-27(18-25)33(34,35)36/h3-18,20,29,31,37,40H,19,21-22H2,1-2H3,(H,38,41)/t29-,31+/m0/s1	HYNKIPABGATMMG-IGYGKHONSA-N	50322909	CHEMBL1210355::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-4-methyl-3-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 6920							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322909&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10438938	117644230		CHEMBL1210355				ZINC58581811	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916251	Cc1c(cccc1C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N(c1ccccc1)S(C)(=O)=O	InChI=1S/C33H34F3N3O4S/c1-23-28(17-10-18-30(23)39(44(2,42)43)27-15-7-4-8-16-27)32(41)38-29(20-24-11-5-3-6-12-24)31(40)22-37-21-25-13-9-14-26(19-25)33(34,35)36/h3-19,29,31,37,40H,20-22H2,1-2H3,(H,38,41)/t29-,31+/m0/s1	XYPSUEPECMURMW-IGYGKHONSA-N	50322910	CHEMBL1210354::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-2-methyl-3-(N-phenylmethylsulfonamido)benzamide	Beta-secretase 2			 620							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322910&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10100482	117644231		CHEMBL1210354				ZINC58598720	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916254	CS(=O)(=O)N(c1ccncc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C31H31F3N4O4S/c1-43(41,42)38(26-13-15-35-16-14-26)27-12-6-10-24(19-27)30(40)37-28(18-22-7-3-2-4-8-22)29(39)21-36-20-23-9-5-11-25(17-23)31(32,33)34/h2-17,19,28-29,36,39H,18,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1	SOGVSPVLCXEDPN-URLMMPGGSA-N	50322907	CHEMBL1210353::CHEMBL1210357::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-4-yl)methylsulfonamido)benzamide hydrochloride	Beta-secretase 2			 10230							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322907&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10371570	117644228		CHEMBL1210357CHEMBL1210353				ZINC58468484	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916257	CS(=O)(=O)N(c1cccnc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F	InChI=1S/C31H31F3N4O4S/c1-43(41,42)38(27-14-7-15-35-20-27)26-13-6-11-24(18-26)30(40)37-28(17-22-8-3-2-4-9-22)29(39)21-36-19-23-10-5-12-25(16-23)31(32,33)34/h2-16,18,20,28-29,36,39H,17,19,21H2,1H3,(H,37,40)/t28-,29+/m0/s1	XGQFYIAWNPUACI-URLMMPGGSA-N	50322906	CHEMBL1210358::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-3-yl)methylsulfonamido)benzamide	Beta-secretase 2			 2290							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322906&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			10483887	117644227		CHEMBL1210358				ZINC58598836	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916260	CS(=O)(=O)N(c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)c1ccccn1	InChI=1S/C31H31F3N4O4S/c1-43(41,42)38(29-15-5-6-16-36-29)26-14-8-12-24(19-26)30(40)37-27(18-22-9-3-2-4-10-22)28(39)21-35-20-23-11-7-13-25(17-23)31(32,33)34/h2-17,19,27-28,35,39H,18,20-21H2,1H3,(H,37,40)/t27-,28+/m0/s1	NLBLQQZAHZCPKB-WUFINQPMSA-N	50322905	CHEMBL1210351::CHEMBL1788375::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-2-yl)methylsulfonamido)benzamide::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-2-yl)methylsulfonamido)benzamide hydrobromide	Beta-secretase 2			 8320							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322905&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			9986236	117644226		CHEMBL1210351CHEMBL1788375				ZINC58594138	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50916263	O[C@H](CNCc1cccc(c1)C(F)(F)F)[C@H](Cc1ccccc1)NC(=O)c1cccc(c1)N1c2ccccc2OS1(=O)=O	InChI=1S/C31H28F3N3O5S/c32-31(33,34)24-12-6-10-22(16-24)19-35-20-28(38)26(17-21-8-2-1-3-9-21)36-30(39)23-11-7-13-25(18-23)37-27-14-4-5-15-29(27)42-43(37,40)41/h1-16,18,26,28,35,38H,17,19-20H2,(H,36,39)/t26-,28+/m0/s1	IEFNQMINVHIYBY-XTEPFMGCSA-N	50322913	CHEMBL1210350	Beta-secretase 2			 1260							ChEMBL	10.1016/j.bmcl.2010.05.111	10.7270/Q2RB75K7	20579874			Clarke, B; Cutler, L; Demont, E; Dingwall, C; Dunsdon, R; Hawkins, J; Howes, C; Hussain, I; Maile, G; Matico, R; Mosley, J; Naylor, A; O'Brien, A; Redshaw, S; Rowland, P; Soleil, V; Smith, KJ; Sweitzer, S; Theobald, P; Vesey, D; Walter, DS; Wayne, G	GlaxoSmithKline	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322913&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49863031	117644234		CHEMBL1210350				ZINC58581810	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50926438	CN1C(N)=NC(C2CC2)(C1=O)c1cccc(c1)-c1cncc(C)c1	InChI=1S/C19H20N4O/c1-12-8-14(11-21-10-12)13-4-3-5-16(9-13)19(15-6-7-15)17(24)23(2)18(20)22-19/h3-5,8-11,15H,6-7H2,1-2H3,(H2,20,22)	FJJHRLCGQGECLA-UHFFFAOYSA-N	50379875	CHEMBL2011964	Beta-secretase 2		 68								ChEMBL	10.1016/j.bmcl.2012.02.013	10.7270/Q2N58NC2	22390835			Cumming, JN; Smith, EM; Wang, L; Misiaszek, J; Durkin, J; Pan, J; Iserloh, U; Wu, Y; Zhu, Z; Strickland, C; Voigt, J; Chen, X; Kennedy, ME; Kuvelkar, R; Hyde, LA; Cox, K; Favreau, L; Czarniecki, MF; Greenlee, WJ; McKittrick, BA; Parker, EM; Stamford, AW	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379875&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59262510	160858958		CHEMBL2011964				ZINC84597173	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50926439	CN1C(N)=NC(C2CC2)(C1=O)c1cccc(c1)-c1cncc(F)c1	InChI=1S/C18H17FN4O/c1-23-16(24)18(13-5-6-13,22-17(23)20)14-4-2-3-11(7-14)12-8-15(19)10-21-9-12/h2-4,7-10,13H,5-6H2,1H3,(H2,20,22)	SYCWNJCJKWUGNM-UHFFFAOYSA-N	50379876	CHEMBL2012006	Beta-secretase 2		 139								ChEMBL	10.1016/j.bmcl.2012.02.013	10.7270/Q2N58NC2	22390835			Cumming, JN; Smith, EM; Wang, L; Misiaszek, J; Durkin, J; Pan, J; Iserloh, U; Wu, Y; Zhu, Z; Strickland, C; Voigt, J; Chen, X; Kennedy, ME; Kuvelkar, R; Hyde, LA; Cox, K; Favreau, L; Czarniecki, MF; Greenlee, WJ; McKittrick, BA; Parker, EM; Stamford, AW	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379876&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11609507	160858959		CHEMBL2012006				ZINC35929931	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50926440	COc1cncc(c1)-c1cccc(c1)C1(N=C(N)N(C)C1=O)C1CC1	InChI=1S/C19H20N4O2/c1-23-17(24)19(14-6-7-14,22-18(23)20)15-5-3-4-12(8-15)13-9-16(25-2)11-21-10-13/h3-5,8-11,14H,6-7H2,1-2H3,(H2,20,22)	VBEPQYVSCSCKOC-UHFFFAOYSA-N	50379877	CHEMBL2012004	Beta-secretase 2		 11								ChEMBL	10.1016/j.bmcl.2012.02.013	10.7270/Q2N58NC2	22390835			Cumming, JN; Smith, EM; Wang, L; Misiaszek, J; Durkin, J; Pan, J; Iserloh, U; Wu, Y; Zhu, Z; Strickland, C; Voigt, J; Chen, X; Kennedy, ME; Kuvelkar, R; Hyde, LA; Cox, K; Favreau, L; Czarniecki, MF; Greenlee, WJ; McKittrick, BA; Parker, EM; Stamford, AW	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59387407	160858960		CHEMBL2012004				ZINC84632616	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50926441	CN1C(N)=NC(C2CC2)(C1=O)c1cccc(c1)-c1cncc(c1)C#N	InChI=1S/C19H17N5O/c1-24-17(25)19(15-5-6-15,23-18(24)21)16-4-2-3-13(8-16)14-7-12(9-20)10-22-11-14/h2-4,7-8,10-11,15H,5-6H2,1H3,(H2,21,23)	YNHHKAKPUCUXLP-UHFFFAOYSA-N	50379878	CHEMBL2012005	Beta-secretase 2		 170								ChEMBL	10.1016/j.bmcl.2012.02.013	10.7270/Q2N58NC2	22390835			Cumming, JN; Smith, EM; Wang, L; Misiaszek, J; Durkin, J; Pan, J; Iserloh, U; Wu, Y; Zhu, Z; Strickland, C; Voigt, J; Chen, X; Kennedy, ME; Kuvelkar, R; Hyde, LA; Cox, K; Favreau, L; Czarniecki, MF; Greenlee, WJ; McKittrick, BA; Parker, EM; Stamford, AW	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379878&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59262314	160858961		CHEMBL2012005				ZINC84616429	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50926442	CN1C(N)=NC(C2CC2)(C1=O)c1cccc(c1)-c1cccnc1	InChI=1S/C18H18N4O/c1-22-16(23)18(14-7-8-14,21-17(22)19)15-6-2-4-12(10-15)13-5-3-9-20-11-13/h2-6,9-11,14H,7-8H2,1H3,(H2,19,21)	WPHFNWNNCCSZJG-UHFFFAOYSA-N	50379879	CHEMBL2012003	Beta-secretase 2		 360								ChEMBL	10.1016/j.bmcl.2012.02.013	10.7270/Q2N58NC2	22390835			Cumming, JN; Smith, EM; Wang, L; Misiaszek, J; Durkin, J; Pan, J; Iserloh, U; Wu, Y; Zhu, Z; Strickland, C; Voigt, J; Chen, X; Kennedy, ME; Kuvelkar, R; Hyde, LA; Cox, K; Favreau, L; Czarniecki, MF; Greenlee, WJ; McKittrick, BA; Parker, EM; Stamford, AW	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379879&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59262423	160858962		CHEMBL2012003				ZINC84604720	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50926443	COc1cccc(c1)-c1cccc(c1)C1(N=C(N)N(C)C1=O)C1CC1	InChI=1S/C20H21N3O2/c1-23-18(24)20(15-9-10-15,22-19(23)21)16-7-3-5-13(11-16)14-6-4-8-17(12-14)25-2/h3-8,11-12,15H,9-10H2,1-2H3,(H2,21,22)	NCNMSGOJBLVCOM-UHFFFAOYSA-N	50379880	CHEMBL2012001	Beta-secretase 2		 7.8								ChEMBL	10.1016/j.bmcl.2012.02.013	10.7270/Q2N58NC2	22390835			Cumming, JN; Smith, EM; Wang, L; Misiaszek, J; Durkin, J; Pan, J; Iserloh, U; Wu, Y; Zhu, Z; Strickland, C; Voigt, J; Chen, X; Kennedy, ME; Kuvelkar, R; Hyde, LA; Cox, K; Favreau, L; Czarniecki, MF; Greenlee, WJ; McKittrick, BA; Parker, EM; Stamford, AW	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379880&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59262421	160858963		CHEMBL2012001				ZINC84602004	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50926444	CN1C(N)=NC(C2CC2)(C1=O)c1cccc(c1)-c1cccc(c1)C#N	InChI=1S/C20H18N4O/c1-24-18(25)20(16-8-9-16,23-19(24)22)17-7-3-6-15(11-17)14-5-2-4-13(10-14)12-21/h2-7,10-11,16H,8-9H2,1H3,(H2,22,23)	RCSWOKAWDNQMMD-UHFFFAOYSA-N	50379881	CHEMBL2012002	Beta-secretase 2		 30								ChEMBL	10.1016/j.bmcl.2012.02.013	10.7270/Q2N58NC2	22390835			Cumming, JN; Smith, EM; Wang, L; Misiaszek, J; Durkin, J; Pan, J; Iserloh, U; Wu, Y; Zhu, Z; Strickland, C; Voigt, J; Chen, X; Kennedy, ME; Kuvelkar, R; Hyde, LA; Cox, K; Favreau, L; Czarniecki, MF; Greenlee, WJ; McKittrick, BA; Parker, EM; Stamford, AW	Merck Research Laboratories	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379881&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			11624078	160858964		CHEMBL2012002				ZINC35949720	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971567	CCC[C@H](O)[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc2N(C)S(=O)(=O)C(C)(C)Cn3cc(CC)c(c1)c23)C(=O)NCC(C)C	InChI=1S/C35H51N5O5S/c1-8-13-30(41)31(34(43)37-19-23(3)4)36-20-27(16-24-14-11-10-12-15-24)38-33(42)26-17-28-25(9-2)21-40-22-35(5,6)46(44,45)39(7)29(18-26)32(28)40/h10-12,14-15,17-18,21,23,27,30-31,36,41H,8-9,13,16,19-20,22H2,1-7H3,(H,37,43)(H,38,42)/t27-,30-,31-/m0/s1	WPEFUXWXSZSMFS-NAYUSWPISA-N	50398472	CHEMBL2179138	Beta-secretase 2		 11								ChEMBL	10.1021/jm3008823	10.7270/Q23F4QT0	22954357			Ghosh, AK; Venkateswara Rao, K; Yadav, ND; Anderson, DD; Gavande, N; Huang, X; Terzyan, S; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398472&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71459108	163347496		CHEMBL2179138				ZINC95572172	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971568	CC(C)CNC(=O)[C@@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)N[C@H](C)c1ccccc1)N(C)S(C)(=O)=O)[C@H](C)O	InChI=1S/C35H47N5O6S/c1-23(2)21-37-35(44)32(25(4)41)36-22-30(17-26-13-9-7-10-14-26)39-34(43)29-18-28(19-31(20-29)40(5)47(6,45)46)33(42)38-24(3)27-15-11-8-12-16-27/h7-16,18-20,23-25,30,32,36,41H,17,21-22H2,1-6H3,(H,37,44)(H,38,42)(H,39,43)/t24-,25+,30+,32+/m1/s1	UZFAOTIMARRSKT-QRMRYRAMSA-N	50398475	CHEMBL2179131	Beta-secretase 2		 120								ChEMBL	10.1021/jm3008823	10.7270/Q23F4QT0	22954357			Ghosh, AK; Venkateswara Rao, K; Yadav, ND; Anderson, DD; Gavande, N; Huang, X; Terzyan, S; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398475	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398475&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46218828	163347499		CHEMBL2179131				ZINC95576260	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971569	CC[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc(cc(c1)C(=O)N[C@H](C)c1ccccc1)N(C)S(C)(=O)=O)C(=O)NCC(C)C	InChI=1S/C35H47N5O5S/c1-7-32(35(43)37-22-24(2)3)36-23-30(18-26-14-10-8-11-15-26)39-34(42)29-19-28(20-31(21-29)40(5)46(6,44)45)33(41)38-25(4)27-16-12-9-13-17-27/h8-17,19-21,24-25,30,32,36H,7,18,22-23H2,1-6H3,(H,37,43)(H,38,41)(H,39,42)/t25-,30+,32+/m1/s1	GPJMPGWBMWJZEY-HFYAYSLXSA-N	50398476	CHEMBL2179130	Beta-secretase 2		 1450								ChEMBL	10.1021/jm3008823	10.7270/Q23F4QT0	22954357			Ghosh, AK; Venkateswara Rao, K; Yadav, ND; Anderson, DD; Gavande, N; Huang, X; Terzyan, S; Tang, J	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398476	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398476&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71455471	163347500		CHEMBL2179130				ZINC95579612	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50972370	CC1=NC(N=C1N)(C1CC1)c1cccc(c1)-c1cncc(Cl)c1	InChI=1S/C18H17ClN4/c1-11-17(20)23-18(22-11,14-5-6-14)15-4-2-3-12(7-15)13-8-16(19)10-21-9-13/h2-4,7-10,14H,5-6H2,1H3,(H2,20,23)	BASHYZBACCLMHK-UHFFFAOYSA-N	50398766	CHEMBL2180033	Beta-secretase 2			 110							ChEMBL	10.1021/jm300991n	10.7270/Q2HH6M79	23017051			Gravenfors, Y; Viklund, J; Blid, J; Ginman, T; Karlstrom, S; Kihlstrom, J; Kolmodin, K; Lindstrom, J; von Berg, S; von Kieseritzky, F; Bogar, K; Slivo, C; Swahn, BM; Olsson, LL; Johansson, P; Eketjall, S; Falting, J; Jeppsson, F; Stromberg, K; Janson, J; Rahm, F	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398766&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			49869312	163347790		CHEMBL2180033				ZINC95576953	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50972371	CC#Cc1cncc(c1)-c1cccc(c1)C1(N=C(C)C(N)=N1)C1CC1	InChI=1S/C21H20N4/c1-3-5-15-10-17(13-23-12-15)16-6-4-7-19(11-16)21(18-8-9-18)24-14(2)20(22)25-21/h4,6-7,10-13,18H,8-9H2,1-2H3,(H2,22,25)	TWHSRVVFCICXII-UHFFFAOYSA-N	50398767	CHEMBL2180037	Beta-secretase 2			 30							ChEMBL	10.1021/jm300991n	10.7270/Q2HH6M79	23017051			Gravenfors, Y; Viklund, J; Blid, J; Ginman, T; Karlstrom, S; Kihlstrom, J; Kolmodin, K; Lindstrom, J; von Berg, S; von Kieseritzky, F; Bogar, K; Slivo, C; Swahn, BM; Olsson, LL; Johansson, P; Eketjall, S; Falting, J; Jeppsson, F; Stromberg, K; Janson, J; Rahm, F	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398767&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	1B1	4B1C	49869313	163347791		CHEMBL2180037				ZINC95580345	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50972372	COc1c(C)cc(cc1C)[C@]1(N=C(C)C(N)=N1)c1cccc(c1)-c1cncnc1	InChI=1S/C23H23N5O/c1-14-8-20(9-15(2)21(14)29-4)23(27-16(3)22(24)28-23)19-7-5-6-17(10-19)18-11-25-13-26-12-18/h5-13H,1-4H3,(H2,24,28)/t23-/m0/s1	PZSMDBYYYKPYFV-QHCPKHFHSA-N	50398768	CHEMBL2180030	Beta-secretase 2			 840							ChEMBL	10.1021/jm300991n	10.7270/Q2HH6M79	23017051			Gravenfors, Y; Viklund, J; Blid, J; Ginman, T; Karlstrom, S; Kihlstrom, J; Kolmodin, K; Lindstrom, J; von Berg, S; von Kieseritzky, F; Bogar, K; Slivo, C; Swahn, BM; Olsson, LL; Johansson, P; Eketjall, S; Falting, J; Jeppsson, F; Stromberg, K; Janson, J; Rahm, F	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398768&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	6TG	4B1D	49836033	163347792		CHEMBL2180030				ZINC68248221	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50960300	CC(C)Cn1cc2[C@@H](CC(C)(C)Cc2n1)NC[C@@H](O)[C@H](Cc1ccccc1)NC(C)=O	InChI=1S/C25H38N4O2/c1-17(2)15-29-16-20-22(12-25(4,5)13-23(20)28-29)26-14-24(31)21(27-18(3)30)11-19-9-7-6-8-10-19/h6-10,16-17,21-22,24,26,31H,11-15H2,1-5H3,(H,27,30)/t21-,22+,24+/m0/s1	PISWYTCLVHPEEE-WMTXJRDZSA-N	50393893	CHEMBL2158258	Beta-secretase 2			 1900							ChEMBL	10.1016/j.bmcl.2012.08.097	10.7270/Q2MS3TVD	23010268			Sund, C; Belda, O; Borkakoti, N; Lindberg, J; Derbyshire, D; Vrang, L; Hamelink, E; Ahgren, C; Woestenenk, E; Wikstrom, K; Eneroth, A; Lindstrom, E; Kalayanov, G	Medivir AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393893&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71462075	163342917		CHEMBL2158258				ZINC95576187	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50960301	CC(C)Cn1cc2[C@H](CC(C)(C)Cc2n1)NC[C@@H](O)[C@H](Cc1ccccc1)NC(C)=O	InChI=1S/C25H38N4O2/c1-17(2)15-29-16-20-22(12-25(4,5)13-23(20)28-29)26-14-24(31)21(27-18(3)30)11-19-9-7-6-8-10-19/h6-10,16-17,21-22,24,26,31H,11-15H2,1-5H3,(H,27,30)/t21-,22-,24+/m0/s1	PISWYTCLVHPEEE-WPFOTENUSA-N	50393887	CHEMBL2158257	Beta-secretase 2			 22							ChEMBL	10.1016/j.bmcl.2012.08.097	10.7270/Q2MS3TVD	23010268			Sund, C; Belda, O; Borkakoti, N; Lindberg, J; Derbyshire, D; Vrang, L; Hamelink, E; Ahgren, C; Woestenenk, E; Wikstrom, K; Eneroth, A; Lindstrom, E; Kalayanov, G	Medivir AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393887&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71462074	163342911		CHEMBL2158257				ZINC95576770	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50960302	CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC(C)(C)Cc2nn(CC(C)(C)C)cc12	InChI=1S/C26H40N4O2/c1-18(31)28-21(12-19-10-8-7-9-11-19)24(32)15-27-22-13-26(5,6)14-23-20(22)16-30(29-23)17-25(2,3)4/h7-11,16,21-22,24,27,32H,12-15,17H2,1-6H3,(H,28,31)/t21-,22?,24+/m0/s1	RUVGZLLBYDXKFE-RRUPDEEPSA-N	50393888	CHEMBL2158256	Beta-secretase 2			 88							ChEMBL	10.1016/j.bmcl.2012.08.097	10.7270/Q2MS3TVD	23010268			Sund, C; Belda, O; Borkakoti, N; Lindberg, J; Derbyshire, D; Vrang, L; Hamelink, E; Ahgren, C; Woestenenk, E; Wikstrom, K; Eneroth, A; Lindstrom, E; Kalayanov, G	Medivir AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393888&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71460382	163342912		CHEMBL2158256				ZINC95571987	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50960303	CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC(C)(C)Cc2nc(CC(C)(C)C)[nH]c12	InChI=1S/C26H40N4O2/c1-17(31)28-19(12-18-10-8-7-9-11-18)22(32)16-27-20-13-26(5,6)14-21-24(20)30-23(29-21)15-25(2,3)4/h7-11,19-20,22,27,32H,12-16H2,1-6H3,(H,28,31)(H,29,30)/t19-,20?,22+/m0/s1	TXOQWIUPZLATHK-PWKISDLSSA-N	50393890	CHEMBL2158255	Beta-secretase 2			 390							ChEMBL	10.1016/j.bmcl.2012.08.097	10.7270/Q2MS3TVD	23010268			Sund, C; Belda, O; Borkakoti, N; Lindberg, J; Derbyshire, D; Vrang, L; Hamelink, E; Ahgren, C; Woestenenk, E; Wikstrom, K; Eneroth, A; Lindstrom, E; Kalayanov, G	Medivir AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393890&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71460381	163342914		CHEMBL2158255				ZINC95580675	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971075	Cc1cc(cn(C)c1=O)C1(N=C(N)c2c1cccc2F)c1cccc(c1)-c1cncnc1	InChI=1S/C25H20FN5O/c1-15-9-19(13-31(2)24(15)32)25(20-7-4-8-21(26)22(20)23(27)30-25)18-6-3-5-16(10-18)17-11-28-14-29-12-17/h3-14H,1-2H3,(H2,27,30)	PWBMZGIIIRTNKV-UHFFFAOYSA-N	50398261	CHEMBL2177919	Beta-secretase 2		 740								ChEMBL	10.1021/jm3009025	10.7270/Q2WW7JTP	22924815			Swahn, BM; Kolmodin, K; Karlstrom, S; von Berg, S; Soderman, P; Holenz, J; Berg, S; Lindstrom, J; Sundstrom, M; Turek, D; Kihlstrom, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjall, S; Georgievska, B; Jeppsson, F; Falting, J	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57406911	163347285		CHEMBL2177919				ZINC95577644	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971076	COc1c(C)cc(nc1C)C1(N=C(N)c2c1cccc2F)c1cccc(c1)-c1cncnc1	InChI=1S/C26H22FN5O/c1-15-10-22(31-16(2)24(15)33-3)26(20-8-5-9-21(27)23(20)25(28)32-26)19-7-4-6-17(11-19)18-12-29-14-30-13-18/h4-14H,1-3H3,(H2,28,32)	DJUIWDIVXGOXBA-UHFFFAOYSA-N	50398262	CHEMBL2177917	Beta-secretase 2		 1700								ChEMBL	10.1021/jm3009025	10.7270/Q2WW7JTP	22924815			Swahn, BM; Kolmodin, K; Karlstrom, S; von Berg, S; Soderman, P; Holenz, J; Berg, S; Lindstrom, J; Sundstrom, M; Turek, D; Kihlstrom, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjall, S; Georgievska, B; Jeppsson, F; Falting, J	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46202743	163347286		CHEMBL2177917				ZINC68205983	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971077	NC1=N[C@@](c2cc(F)cc(F)c12)(c1cccc(c1)-c1cncnc1)c1ccnc(c1)C(F)F	InChI=1S/C24H15F4N5/c25-17-8-18-21(19(26)9-17)23(29)33-24(18,16-4-5-32-20(7-16)22(27)28)15-3-1-2-13(6-15)14-10-30-12-31-11-14/h1-12,22H,(H2,29,33)/t24-/m0/s1	XCGKBIOLPVAHCG-DEOSSOPVSA-N	50398263	CHEMBL2177914	Beta-secretase 2		 770								ChEMBL	10.1021/jm3009025	10.7270/Q2WW7JTP	22924815			Swahn, BM; Kolmodin, K; Karlstrom, S; von Berg, S; Soderman, P; Holenz, J; Berg, S; Lindstrom, J; Sundstrom, M; Turek, D; Kihlstrom, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjall, S; Georgievska, B; Jeppsson, F; Falting, J	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398263&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71451832	163347287		CHEMBL2177914				ZINC95573460	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971078	NC1=N[C@@](c2cccc(F)c12)(c1cccc(c1)-c1cncnc1)c1ccnc(c1)C(F)F	InChI=1S/C24H16F3N5/c25-19-6-2-5-18-21(19)23(28)32-24(18,17-7-8-31-20(10-17)22(26)27)16-4-1-3-14(9-16)15-11-29-13-30-12-15/h1-13,22H,(H2,28,32)/t24-/m0/s1	MRXBCEQZNKUUIP-DEOSSOPVSA-N	50398264	CHEMBL2177913	Beta-secretase 2		 370								ChEMBL	10.1021/jm3009025	10.7270/Q2WW7JTP	22924815			Swahn, BM; Kolmodin, K; Karlstrom, S; von Berg, S; Soderman, P; Holenz, J; Berg, S; Lindstrom, J; Sundstrom, M; Turek, D; Kihlstrom, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjall, S; Georgievska, B; Jeppsson, F; Falting, J	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	32D	4B05	46202416	163347288		CHEMBL2177913				ZINC68205977	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971079	NC1=N[C@](c2cccc(F)c12)(c1ccncc1)c1cccc(c1)-c1cncnc1	InChI=1S/C23H16FN5/c24-20-6-2-5-19-21(20)22(25)29-23(19,17-7-9-26-10-8-17)18-4-1-3-15(11-18)16-12-27-14-28-13-16/h1-14H,(H2,25,29)/t23-/m1/s1	JTYGZAPMRYLRCN-HSZRJFAPSA-N	50398265	CHEMBL2177904	Beta-secretase 2		 790								ChEMBL	10.1021/jm3009025	10.7270/Q2WW7JTP	22924815			Swahn, BM; Kolmodin, K; Karlstrom, S; von Berg, S; Soderman, P; Holenz, J; Berg, S; Lindstrom, J; Sundstrom, M; Turek, D; Kihlstrom, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjall, S; Georgievska, B; Jeppsson, F; Falting, J	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398265&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			46205968	163347289		CHEMBL2177904				ZINC95577655	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50960304	CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC(C)(C)Cc2oc(CC(C)(C)C)nc12	InChI=1S/C26H39N3O3/c1-17(30)28-19(12-18-10-8-7-9-11-18)21(31)16-27-20-13-26(5,6)14-22-24(20)29-23(32-22)15-25(2,3)4/h7-11,19-21,27,31H,12-16H2,1-6H3,(H,28,30)/t19-,20?,21+/m0/s1	DYIGGBRCCOVEFU-SIGULFFNSA-N	50393891	CHEMBL2158254	Beta-secretase 2			>10000							ChEMBL	10.1016/j.bmcl.2012.08.097	10.7270/Q2MS3TVD	23010268			Sund, C; Belda, O; Borkakoti, N; Lindberg, J; Derbyshire, D; Vrang, L; Hamelink, E; Ahgren, C; Woestenenk, E; Wikstrom, K; Eneroth, A; Lindstrom, E; Kalayanov, G	Medivir AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393891&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71451365	163342915		CHEMBL2158254				ZINC95578394	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50960305	CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC(C)(C)Oc2sc(CC(C)(C)C)cc12	InChI=1S/C26H38N2O3S/c1-17(29)28-21(12-18-10-8-7-9-11-18)23(30)16-27-22-15-26(5,6)31-24-20(22)13-19(32-24)14-25(2,3)4/h7-11,13,21-23,27,30H,12,14-16H2,1-6H3,(H,28,29)/t21-,22?,23+/m0/s1	YLIBYDKWVPKMKX-OCESARCHSA-N	50393892	CHEMBL2158253	Beta-secretase 2			 3.9							ChEMBL	10.1016/j.bmcl.2012.08.097	10.7270/Q2MS3TVD	23010268			Sund, C; Belda, O; Borkakoti, N; Lindberg, J; Derbyshire, D; Vrang, L; Hamelink, E; Ahgren, C; Woestenenk, E; Wikstrom, K; Eneroth, A; Lindstrom, E; Kalayanov, G	Medivir AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393892&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71449561	163342916		CHEMBL2158253				ZINC95574915	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50960306	CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC(C)(C)Oc2ccc(CC(C)(C)C)cc12	InChI=1S/C28H40N2O3/c1-19(31)30-23(15-20-10-8-7-9-11-20)25(32)18-29-24-17-28(5,6)33-26-13-12-21(14-22(24)26)16-27(2,3)4/h7-14,23-25,29,32H,15-18H2,1-6H3,(H,30,31)/t23-,24-,25+/m0/s1	JLDYIPLIAROYMO-CCDWMCETSA-N	50393889	CHEMBL2158252	Beta-secretase 2			 4.5							ChEMBL	10.1016/j.bmcl.2012.08.097	10.7270/Q2MS3TVD	23010268			Sund, C; Belda, O; Borkakoti, N; Lindberg, J; Derbyshire, D; Vrang, L; Hamelink, E; Ahgren, C; Woestenenk, E; Wikstrom, K; Eneroth, A; Lindstrom, E; Kalayanov, G	Medivir AB	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393889&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71460380	163342913		CHEMBL2158252				ZINC95579585	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971170	CCn1cc(cc(C)c1=O)[C@@]1(N=C(N)c2c1cccc2F)c1cccc(c1)C#CC1CC1	InChI=1S/C27H24FN3O/c1-3-31-16-21(14-17(2)26(31)32)27(22-8-5-9-23(28)24(22)25(29)30-27)20-7-4-6-19(15-20)13-12-18-10-11-18/h4-9,14-16,18H,3,10-11H2,1-2H3,(H2,29,30)/t27-/m0/s1	MTNHQSSEAULFMW-MHZLTWQESA-N	50398267	CHEMBL2177304	Beta-secretase 2		 78								ChEMBL	10.1021/jm3009025	10.7270/Q2WW7JTP	22924815			Swahn, BM; Kolmodin, K; Karlstrom, S; von Berg, S; Soderman, P; Holenz, J; Berg, S; Lindstrom, J; Sundstrom, M; Turek, D; Kihlstrom, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjall, S; Georgievska, B; Jeppsson, F; Falting, J	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50398267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50398267&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71449970	163347291		CHEMBL2177304				ZINC95579272	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50971171	CCn1cc(cc(C)c1=O)[C@@]1(N=C(N)c2c1cccc2F)c1cccc(c1)-c1cncc(c1)C#CC	InChI=1S/C30H25FN4O/c1-4-8-20-14-22(17-33-16-20)21-9-6-10-23(15-21)30(24-13-19(3)29(36)35(5-2)18-24)25-11-7-12-26(31)27(25)28(32)34-30/h6-7,9-18H,5H2,1-3H3,(H2,32,34)/t30-/m0/s1	TUGLMYZSOPKJOA-PMERELPUSA-N	50393088	CHEMBL2152903	Beta-secretase 2		 7.5								ChEMBL	10.1021/jm3009025	10.7270/Q2WW7JTP	22924815			Swahn, BM; Kolmodin, K; Karlstrom, S; von Berg, S; Soderman, P; Holenz, J; Berg, S; Lindstrom, J; Sundstrom, M; Turek, D; Kihlstrom, J; Slivo, C; Andersson, L; Pyring, D; Rotticci, D; Ohberg, L; Kers, A; Bogar, K; von Kieseritzky, F; Bergh, M; Olsson, LL; Janson, J; Eketjall, S; Georgievska, B; Jeppsson, F; Falting, J	AstraZeneca	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393088&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	I6X	4B00	57406537	163342112		CHEMBL2152903				ZINC95574104	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486208	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(OCC2CC2)c(F)cc1F	InChI=1S/C20H25F2N3O4/c1-25-18(26)14-5-12(9-27-2)29-10-20(14,24-19(25)23)13-6-17(16(22)7-15(13)21)28-8-11-3-4-11/h6-7,11-12,14H,3-5,8-10H2,1-2H3,(H2,23,24)/t12-,14+,20-/m1/s1	RBLJMOCKZFVTAA-TUXXCZFBSA-N	227972	US10047098, 5	Beta-secretase 2		 82.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227972&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473675	374884912							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486224	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cc(ncn2)-n2cccn2)ccc1F	InChI=1S/C24H24FN7O3/c1-31-22(33)17-10-19(14-3-4-14)34-12-24(17,30-23(31)26)16-9-15(5-6-18(16)25)35-21-11-20(27-13-28-21)32-8-2-7-29-32/h2,5-9,11,13-14,17,19H,3-4,10,12H2,1H3,(H2,26,30)/t17-,19+,24+/m0/s1	FLICNROLCQURSA-RGZWJVDOSA-N	227981	US10047098, 13	Beta-secretase 2		 23.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227981&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473729	374884921							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046500	COCCCCC1(CNC(=O)[C@@H]2CNC[C@@H](C2)NS(=O)(=O)c2ccc(C)cc2)c2ccccc2Oc2ccccc12	InChI=1S/C32H39N3O5S/c1-23-13-15-26(16-14-23)41(37,38)35-25-19-24(20-33-21-25)31(36)34-22-32(17-7-8-18-39-2)27-9-3-5-11-29(27)40-30-12-6-4-10-28(30)32/h3-6,9-16,24-25,33,35H,7-8,17-22H2,1-2H3,(H,34,36)/t24-,25+/m0/s1	LBPUIWQYAGTBDC-LOSJGSFVSA-N	50427040	CHEMBL2322207	Beta-secretase 2			>30000							ChEMBL	10.1021/jm301706j	10.7270/Q25X2B8Z	23360239			Ostermann, N; Ruedisser, S; Ehrhardt, C; Breitenstein, W; Marzinzik, A; Jacoby, E; Vangrevelinghe, E; Ottl, J; Klumpp, M; Hartwieg, JC; Cumin, F; Hassiepen, U; Trappe, J; Sedrani, R; Geisse, S; Gerhartz, B; Richert, P; Francotte, E; Wagner, T; Kromer, M; Kosaka, T; Webb, RL; Rigel, DF; Maibaum, J; Baeschlin, DK	Novartis Pharma AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427040&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	0N0	4GJD	11963435	164155915		CHEMBL2322207				ZINC95584308	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046524	O=C(Cc1ccc(cc1)-c1ccccc1)NCc1ccc(CN2Cc3ccccc3C2)cc1	InChI=1S/C30H28N2O/c33-30(18-23-14-16-27(17-15-23)26-6-2-1-3-7-26)31-19-24-10-12-25(13-11-24)20-32-21-28-8-4-5-9-29(28)22-32/h1-17H,18-22H2,(H,31,33)	YXDJXWNOSXNEIR-UHFFFAOYSA-N	50427045	CHEMBL2322830	Beta-secretase 2			>1000000							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427045&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71583022	164155920		CHEMBL2322830				ZINC95584503	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046525	NCc1ccc(CNC(=O)Cc2ccc(cc2)-c2ccccc2)cc1	InChI=1S/C22H22N2O/c23-15-18-6-8-19(9-7-18)16-24-22(25)14-17-10-12-21(13-11-17)20-4-2-1-3-5-20/h1-13H,14-16,23H2,(H,24,25)	LMLAEEGHIFQWKP-UHFFFAOYSA-N	50427046	CHEMBL2322833	Beta-secretase 2			>1000000							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427046&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71584523	164155921		CHEMBL2322833				ZINC95582831	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046532	NCc1ccc(CNC(=O)Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)cc1	InChI=1S/C23H21F3N2O/c24-23(25,26)21-3-1-2-20(13-21)19-10-8-16(9-11-19)12-22(29)28-15-18-6-4-17(14-27)5-7-18/h1-11,13H,12,14-15,27H2,(H,28,29)	SOKKPDFWPPGKPQ-UHFFFAOYSA-N	50427053	CHEMBL2322541	Beta-secretase 2			 319000							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427053&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71582924	164155928		CHEMBL2322541				ZINC95585541	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046537	NCc1ccc(CNC(=O)Cc2ccc(cc2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1	InChI=1S/C24H20F6N2O/c25-23(26,27)20-10-19(11-21(12-20)24(28,29)30)18-7-5-15(6-8-18)9-22(33)32-14-17-3-1-16(13-31)2-4-17/h1-8,10-12H,9,13-14,31H2,(H,32,33)	CFZPYKOAYUTDGC-UHFFFAOYSA-N	50427056	CHEMBL2322539	Beta-secretase 2			 33200							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427056&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71584650	164155931		CHEMBL2322539				ZINC95580992	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046546	CC(C)C(C(=O)NCc1ccc(CN)cc1)c1ccc(cc1)-c1ccccc1	InChI=1S/C25H28N2O/c1-18(2)24(25(28)27-17-20-10-8-19(16-26)9-11-20)23-14-12-22(13-15-23)21-6-4-3-5-7-21/h3-15,18,24H,16-17,26H2,1-2H3,(H,27,28)	KZBAGUJKIHPQRQ-UHFFFAOYSA-N	50427057	CHEMBL2322537	Beta-secretase 2			 100500							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427057&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71584648	164155932		CHEMBL2322537				ZINC95581993	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046547	NCc1ccc(CNC(=O)C(Cc2ccccc2)c2ccc(cc2)-c2ccccc2)cc1	InChI=1S/C29H28N2O/c30-20-23-11-13-24(14-12-23)21-31-29(32)28(19-22-7-3-1-4-8-22)27-17-15-26(16-18-27)25-9-5-2-6-10-25/h1-18,28H,19-21,30H2,(H,31,32)	HSGKBGCFILFOAC-UHFFFAOYSA-N	50427058	CHEMBL2322538	Beta-secretase 2			 21000							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427058&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71584649	164155933		CHEMBL2322538				ZINC95580957	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046533	NCc1ccc(CNC(=O)Cc2ccc(cc2)-c2c(F)c(F)c(F)c(F)c2F)cc1	InChI=1S/C22H17F5N2O/c23-18-17(19(24)21(26)22(27)20(18)25)15-7-5-12(6-8-15)9-16(30)29-11-14-3-1-13(10-28)2-4-14/h1-8H,9-11,28H2,(H,29,30)	IOCGHYIPZDZBAO-UHFFFAOYSA-N	50427054	CHEMBL2322540	Beta-secretase 2			 245900							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427054&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71582923	164155929		CHEMBL2322540				ZINC95580784	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51046535	C[C@@H](C(=O)NCc1ccc(CN)cc1)c1ccc(c(F)c1)-c1ccccc1	InChI=1S/C23H23FN2O/c1-16(23(27)26-15-18-9-7-17(14-25)8-10-18)20-11-12-21(22(24)13-20)19-5-3-2-4-6-19/h2-13,16H,14-15,25H2,1H3,(H,26,27)/t16-/m1/s1	FHYZRKQSKXWLMZ-MRXNPFEDSA-N	50427055	CHEMBL2322536	Beta-secretase 2			 207200							ChEMBL	10.1021/jm301127x	10.7270/Q2XG9SG1	23374014			Mok, NY; Chadwick, J; Kellett, KA; Casas-Arce, E; Hooper, NM; Johnson, AP; Fishwick, CW	University of Leeds	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427055&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71584647	164155930		CHEMBL2322536				ZINC95580786	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51047860	COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]1CNC[C@H]1Cc1ccccc1)C(C)C	InChI=1S/C27H38N2O4/c1-20(2)29(19-24-18-28-17-23(24)15-21-9-6-5-7-10-21)27(30)22-11-12-25(32-4)26(16-22)33-14-8-13-31-3/h5-7,9-12,16,20,23-24,28H,8,13-15,17-19H2,1-4H3/t23-,24+/m1/s1	PHCCFIGNVNPMML-RPWUZVMVSA-N	50427564	CHEMBL2322611	Beta-secretase 2			>30000							ChEMBL	10.1021/jm3017078	10.7270/Q2FB5487	23425156			Lorthiois, E; Breitenstein, W; Cumin, F; Ehrhardt, C; Francotte, E; Jacoby, E; Ostermann, N; Sellner, H; Kosaka, T; Webb, RL; Rigel, DF; Hassiepen, U; Richert, P; Wagner, T; Maibaum, J	Novartis Pharma AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427564&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	0LT	4GJ7	11518143	164156439		CHEMBL2322611				ZINC95585360	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469337	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H17ClFN5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	VBWPFVMZZPWFMD-KRWDZBQOSA-N	143218	US8940748, 34::US9029362, 34::US9687494, 34	Beta-secretase 2		 220						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51039270	251971813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469339	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C18H17F4N5O3S/c1-17(9-31(29,30)27(2)16(23)26-17)12-7-11(4-5-13(12)19)25-15(28)14-6-3-10(8-24-14)18(20,21)22/h3-8H,9H2,1-2H3,(H2,23,26)(H,25,28)/t17-/m0/s1	XBJQDMHXDUQMJV-KRWDZBQOSA-N	143219	US8940748, 26::US9029362, 26::US9687494, 26	Beta-secretase 2		 2460						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143219&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111677	251971814							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469341	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	YHYKUSGACIYRML-KRWDZBQOSA-N	47353	BDBM143220::US9029362, 173::US9687494, 25	Beta-secretase 2		 370						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47353&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			1484169	24824350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469343	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2cnc(C)cn2)ccc1F	InChI=1S/C17H19FN6O3S/c1-10-7-21-14(8-20-10)15(25)22-11-4-5-13(18)12(6-11)17(2)9-28(26,27)24(3)16(19)23-17/h4-8H,9H2,1-3H3,(H2,19,23)(H,22,25)/t17-/m0/s1	QEDBRPQZTWTMTK-KRWDZBQOSA-N	143221	US8940748, 36::US9029362, 36::US9687494, 36	Beta-secretase 2		 4850						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51352402	251971816							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469345	COc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H18F2N6O4S/c1-17(8-30(27,28)25(2)16(20)24-17)10-4-9(5-11(18)14(10)19)23-15(26)12-6-22-13(29-3)7-21-12/h4-7H,8H2,1-3H3,(H2,20,24)(H,23,26)/t17-/m0/s1	QGPBROSNFKNVFL-KRWDZBQOSA-N	143222	US8940748, 40di::US9029362, 40di::US9687494, 40di	Beta-secretase 2		 2150						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143222&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111419	251971817							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469347	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(C)cn2)ccc1F	InChI=1S/C18H20FN5O3S/c1-11-4-7-15(21-9-11)16(25)22-12-5-6-14(19)13(8-12)18(2)10-28(26,27)24(3)17(20)23-18/h4-9H,10H2,1-3H3,(H2,20,23)(H,22,25)/t18-/m0/s1	LWWIOJQKELULTO-SFHVURJKSA-N	143223	US8940748, 35::US9029362, 35::US9687494, 35	Beta-secretase 2		 450						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111335	251971818							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469349	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(NC(=O)c2ccc(F)cn2)c1F	InChI=1S/C17H16F3N5O3S/c1-17(8-29(27,28)25(2)16(21)24-17)13-10(19)4-6-11(14(13)20)23-15(26)12-5-3-9(18)7-22-12/h3-7H,8H2,1-2H3,(H2,21,24)(H,23,26)/t17-/m0/s1	VXLAYHUGSSZHSG-KRWDZBQOSA-N	143224	US8940748, 173::US9687494, 173	Beta-secretase 2		 470						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143224&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111673	251971819							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469352	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(cs1)-c1ccc(F)c(c1)C#N	InChI=1S/C16H15FN4O2S2/c1-16(9-25(22,23)21(2)15(19)20-16)14-6-12(8-24-14)10-3-4-13(17)11(5-10)7-18/h3-6,8H,9H2,1-2H3,(H2,19,20)/t16-/m0/s1	BRXXBTMKBTXEJJ-INIZCTEOSA-N	143226	US8940748, 46::US9029362, 46::US9687494, 46	Beta-secretase 2		 8230						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143226&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111513	251971821							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469354	CC#Cc1cncc(c1)-c1cc(Cl)c(s1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H17ClN4O2S2/c1-4-5-11-6-12(9-20-8-11)14-7-13(18)15(25-14)17(2)10-26(23,24)22(3)16(19)21-17/h6-9H,10H2,1-3H3,(H2,19,21)/t17-/m0/s1	VKVMIZCLMUKTTA-KRWDZBQOSA-N	143227	US8940748, 52::US9029362, 52::US9687494, 52	Beta-secretase 2		 370						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	66J	5HTZ	68111516	251971822							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
469356	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(=N)N1	InChI=1S/C17H19FN6O4S/c1-17(9-29(26,27)24(2)16(19)23-17)11-6-10(4-5-12(11)18)22-15(25)13-7-21-14(28-3)8-20-13/h4-8H,9H2,1-3H3,(H2,19,23)(H,22,25)/t17-/m0/s1	DJIXTIKKTNRBEW-KRWDZBQOSA-N	143228	US8940748, 40ai::US9029362, 40ai::US9687494, 40ai	Beta-secretase 2		 1990						5		US Patent		10.7270/Q2CJ8BN7		aid1794955	US9687494	PubChem, PC; Scott, JD; Stamford, AW; Gilbert, EJ; Cumming, JN; Iserloh, U	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			68111681	251971823							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060282	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C16H13ClF5N5O2/c1-15(16(21,22)6-29-14(23)25-15)8-4-7(2-3-10(8)18)24-12(28)11-9(17)5-27(26-11)13(19)20/h2-5,13H,6H2,1H3,(H2,23,25)(H,24,28)/t15-/m1/s1	YEHRNWYFLZJYAG-OAHLLOKOSA-N	50432610	CHEMBL2347202	Beta-secretase 2			 11							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432610&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241302	164161485		CHEMBL2347202				ZINC95602453	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060283	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccn(n2)C(F)F)ccc1F	InChI=1S/C16H14F5N5O2/c1-15(16(20,21)7-28-14(22)24-15)9-6-8(2-3-10(9)17)23-12(27)11-4-5-26(25-11)13(18)19/h2-6,13H,7H2,1H3,(H2,22,24)(H,23,27)/t15-/m1/s1	ZGKZXHJOPQGOHJ-OAHLLOKOSA-N	50432611	CHEMBL2347201	Beta-secretase 2			 18							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432611&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241206	164161486		CHEMBL2347201				ZINC95604776	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060284	Cn1cc(Cl)c(n1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C16H15ClF3N5O2/c1-15(16(19,20)7-27-14(21)23-15)9-5-8(3-4-11(9)18)22-13(26)12-10(17)6-25(2)24-12/h3-6H,7H2,1-2H3,(H2,21,23)(H,22,26)/t15-/m1/s1	YAOLSFUTRVAXLB-OAHLLOKOSA-N	50432612	CHEMBL2347200	Beta-secretase 2			 31							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432612&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241937	164161487		CHEMBL2347200				ZINC95605312	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060285	Cn1ccc(n1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C16H16F3N5O2/c1-15(16(18,19)8-26-14(20)22-15)10-7-9(3-4-11(10)17)21-13(25)12-5-6-24(2)23-12/h3-7H,8H2,1-2H3,(H2,20,22)(H,21,25)/t15-/m1/s1	OTZXLWIDYPQTOQ-OAHLLOKOSA-N	50432613	CHEMBL2347199	Beta-secretase 2			 106							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432613&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241205	164161488		CHEMBL2347199				ZINC95604129	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060286	CC#CCOc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C20H18F3N5O3/c1-3-4-7-30-16-10-25-15(9-26-16)17(29)27-12-5-6-14(21)13(8-12)19(2)20(22,23)11-31-18(24)28-19/h5-6,8-10H,7,11H2,1-2H3,(H2,24,28)(H,27,29)/t19-/m1/s1	RULHZYOVKRJKJG-LJQANCHMSA-N	50432614	CHEMBL2347198	Beta-secretase 2			 101							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432614&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71619629	164161489		CHEMBL2347198				ZINC95602452	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060287	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C19H16F3N5O3/c1-3-6-29-15-9-24-14(8-25-15)16(28)26-11-4-5-13(20)12(7-11)18(2)19(21,22)10-30-17(23)27-18/h1,4-5,7-9H,6,10H2,2H3,(H2,23,27)(H,26,28)/t18-/m1/s1	VZVGCEGYUMDYMU-GOSISDBHSA-N	50432615	CHEMBL2347197	Beta-secretase 2			 175							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432615	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432615&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71718352	164161490		CHEMBL2347197				ZINC95601539	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060288	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C18H15F6N5O3/c1-16(17(20,21)7-32-15(25)29-16)10-4-9(2-3-11(10)19)28-14(30)12-5-27-13(6-26-12)31-8-18(22,23)24/h2-6H,7-8H2,1H3,(H2,25,29)(H,28,30)/t16-/m1/s1	OZLMKUNCILJVMA-MRXNPFEDSA-N	50432616	CHEMBL2347196	Beta-secretase 2			 943							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432616	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432616&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71663858	164161491		CHEMBL2347196				ZINC95605582	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060289	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C17H16F3N5O3/c1-16(17(19,20)8-28-15(21)25-16)10-5-9(3-4-11(10)18)24-14(26)12-6-23-13(27-2)7-22-12/h3-7H,8H2,1-2H3,(H2,21,25)(H,24,26)/t16-/m1/s1	YPYVNGJSDUTKIO-MRXNPFEDSA-N	50432617	CHEMBL2347195	Beta-secretase 2			 119							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432617	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432617&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71663695	164161492		CHEMBL2347195				ZINC95604139	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060290	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ncc(Cl)cn2)ccc1F	InChI=1S/C16H13ClF3N5O2/c1-15(16(19,20)7-27-14(21)25-15)10-4-9(2-3-11(10)18)24-13(26)12-22-5-8(17)6-23-12/h2-6H,7H2,1H3,(H2,21,25)(H,24,26)/t15-/m1/s1	CZXDOHMWCZCKBD-OAHLLOKOSA-N	50432618	CHEMBL2347194	Beta-secretase 2			 23							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432618	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432618&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241932	164161493		CHEMBL2347194				ZINC95604170	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060291	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C17H13Cl2F3N4O2/c1-16(17(21,22)7-28-15(23)26-16)10-5-9(2-3-12(10)20)25-14(27)13-11(19)4-8(18)6-24-13/h2-6H,7H2,1H3,(H2,23,26)(H,25,27)/t16-/m1/s1	SAJHJLBNBLIXLI-MRXNPFEDSA-N	50432619	CHEMBL2347193	Beta-secretase 2			 12							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432619	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432619&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241825	164161494		CHEMBL2347193				ZINC95605503	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060292	Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C18H16ClF3N4O2/c1-9-5-10(19)7-24-14(9)15(27)25-11-3-4-13(20)12(6-11)17(2)18(21,22)8-28-16(23)26-17/h3-7H,8H2,1-2H3,(H2,23,26)(H,25,27)/t17-/m1/s1	LSQOOIQMQSYBNI-QGZVFWFLSA-N	50432620	CHEMBL2347192	Beta-secretase 2			 10.0							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432620	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432620&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53230332	164161495		CHEMBL2347192				ZINC95603312	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060293	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(OCC(F)(F)C(F)F)cn2)ccc1F	InChI=1S/C20H17F7N4O3/c1-18(20(26,27)9-34-17(28)31-18)12-6-10(2-4-13(12)21)30-15(32)14-5-3-11(7-29-14)33-8-19(24,25)16(22)23/h2-7,16H,8-9H2,1H3,(H2,28,31)(H,30,32)/t18-/m1/s1	UHUWMAOCKWUXRP-GOSISDBHSA-N	50432621	CHEMBL2347191	Beta-secretase 2			 9440							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432621	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432621&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53240812	164161496		CHEMBL2347191				ZINC95604801	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060294	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C19H16F6N4O3/c1-17(18(21,22)8-32-16(26)29-17)12-6-10(2-4-13(12)20)28-15(30)14-5-3-11(7-27-14)31-9-19(23,24)25/h2-7H,8-9H2,1H3,(H2,26,29)(H,28,30)/t17-/m1/s1	QIDZVQSSIOGZDK-QGZVFWFLSA-N	50432622	CHEMBL2347368	Beta-secretase 2			 7490							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432622	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432622&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241933	164161497		CHEMBL2347368				ZINC95603901	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060295	CCOc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C19H19F3N4O3/c1-3-28-12-5-7-15(24-9-12)16(27)25-11-4-6-14(20)13(8-11)18(2)19(21,22)10-29-17(23)26-18/h4-9H,3,10H2,1-2H3,(H2,23,26)(H,25,27)/t18-/m1/s1	DWKGLYKXNUIYDM-GOSISDBHSA-N	50432623	CHEMBL2347367	Beta-secretase 2			 904							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432623	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432623&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	6T9	3ZLQ,4J0T	71305034	164161498		CHEMBL2347367				ZINC95601198	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060296	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(OC(F)(F)F)cn2)ccc1F	InChI=1S/C18H14F6N4O3/c1-16(17(20,21)8-30-15(25)28-16)11-6-9(2-4-12(11)19)27-14(29)13-5-3-10(7-26-13)31-18(22,23)24/h2-7H,8H2,1H3,(H2,25,28)(H,27,29)/t16-/m1/s1	MQEXMAQRIOGEIK-MRXNPFEDSA-N	50432624	CHEMBL2347366	Beta-secretase 2			 245							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432624	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432624&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71663694	164161499		CHEMBL2347366				ZINC95605541	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060297	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C18H17F3N4O3/c1-17(18(20,21)9-28-16(22)25-17)12-7-10(3-5-13(12)19)24-15(26)14-6-4-11(27-2)8-23-14/h3-8H,9H2,1-2H3,(H2,22,25)(H,24,26)/t17-/m1/s1	HNRVVAHVDIBECJ-QGZVFWFLSA-N	50432625	CHEMBL2347365	Beta-secretase 2			 45							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432625&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71663693	164161500		CHEMBL2347365				ZINC95603945	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060298	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(cn2)C#C)ccc1F	InChI=1S/C19H15F3N4O2/c1-3-11-4-7-15(24-9-11)16(27)25-12-5-6-14(20)13(8-12)18(2)19(21,22)10-28-17(23)26-18/h1,4-9H,10H2,2H3,(H2,23,26)(H,25,27)/t18-/m1/s1	CQEOGCIXQLQZTF-GOSISDBHSA-N	50432626	CHEMBL2347364	Beta-secretase 2			 47							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432626&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71663692	164161501		CHEMBL2347364				ZINC95601107	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060299	Cc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)OCC1(F)F	InChI=1S/C18H17F3N4O2/c1-10-3-6-14(23-8-10)15(26)24-11-4-5-13(19)12(7-11)17(2)18(20,21)9-27-16(22)25-17/h3-8H,9H2,1-2H3,(H2,22,25)(H,24,26)/t17-/m1/s1	ZCNHRJGLINKQLI-QGZVFWFLSA-N	50432627	CHEMBL2347363	Beta-secretase 2			 30							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432627&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71663691	164161502		CHEMBL2347363				ZINC95605829	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060300	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C18H14F3N5O2/c1-17(18(20,21)9-28-16(23)26-17)12-6-11(3-4-13(12)19)25-15(27)14-5-2-10(7-22)8-24-14/h2-6,8H,9H2,1H3,(H2,23,26)(H,25,27)/t17-/m1/s1	DVMUZHLUMHPCGZ-QGZVFWFLSA-N	50432628	CHEMBL2347215	Beta-secretase 2			 24							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432628&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241828	164161503		CHEMBL2347215				ZINC95602954	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060301	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H14F4N4O2/c1-16(17(20,21)8-27-15(22)25-16)11-6-10(3-4-12(11)19)24-14(26)13-5-2-9(18)7-23-13/h2-7H,8H2,1H3,(H2,22,25)(H,24,26)/t16-/m1/s1	FBXUIKJIHZEJMQ-MRXNPFEDSA-N	50432629	CHEMBL2347214	Beta-secretase 2			 22							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432629	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432629&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241710	164161504		CHEMBL2347214				ZINC95601736	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060302	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccccn2)ccc1F	InChI=1S/C17H15F3N4O2/c1-16(17(19,20)9-26-15(21)24-16)11-8-10(5-6-12(11)18)23-14(25)13-4-2-3-7-22-13/h2-8H,9H2,1H3,(H2,21,24)(H,23,25)/t16-/m1/s1	SYEULBIUWRUKDF-MRXNPFEDSA-N	50432630	CHEMBL2347213	Beta-secretase 2			 36							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432630	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432630&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241826	164161505		CHEMBL2347213				ZINC95601764	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060303	C[C@@]1(N=C(N)SCC1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H14ClF3N4OS/c1-16(17(20,21)8-27-15(22)25-16)11-6-10(3-4-12(11)19)24-14(26)13-5-2-9(18)7-23-13/h2-7H,8H2,1H3,(H2,22,25)(H,24,26)/t16-/m1/s1	FHIOVECNBCMMAE-MRXNPFEDSA-N	50432631	CHEMBL2347212	Beta-secretase 2			 10.0							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432631	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432631&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59250998	164161506		CHEMBL2347212				ZINC95602438	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060304	C[C@]1(CCSC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H16ClFN4OS/c1-17(6-7-25-16(20)23-17)12-8-11(3-4-13(12)19)22-15(24)14-5-2-10(18)9-21-14/h2-5,8-9H,6-7H2,1H3,(H2,20,23)(H,22,24)/t17-/m0/s1	VVZZZUNCWSTIOI-KRWDZBQOSA-N	50432632	CHEMBL2347211	Beta-secretase 2			 9.0							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432632&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	C6U	6JSG	50938551	164161507		CHEMBL2347211				ZINC34951408	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060305	C[C@@]1(N=C(N)OCC1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H14ClF3N4O2/c1-16(17(20,21)8-27-15(22)25-16)11-6-10(3-4-12(11)19)24-14(26)13-5-2-9(18)7-23-13/h2-7H,8H2,1H3,(H2,22,25)(H,24,26)/t16-/m1/s1	FQQAQHRJTBVECP-MRXNPFEDSA-N	50432598	CHEMBL2347210	Beta-secretase 2			 15							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432598&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241709	164161473		CHEMBL2347210				ZINC95605635	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51060306	C[C@]1(CCOC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H16ClFN4O2/c1-17(6-7-25-16(20)23-17)12-8-11(3-4-13(12)19)22-15(24)14-5-2-10(18)9-21-14/h2-5,8-9H,6-7H2,1H3,(H2,20,23)(H,22,24)/t17-/m0/s1	HIFMUVLULGJLTJ-KRWDZBQOSA-N	50432599	CHEMBL2347209::US8999980, I-8	Beta-secretase 2			 52							ChEMBL	10.1021/jm400225m	10.7270/Q2RX9DFZ	23590342			Hilpert, H; Guba, W; Woltering, TJ; Wostl, W; Pinard, E; Mauser, H; Mayweg, AV; Rogers-Evans, M; Humm, R; Krummenacher, D; Muser, T; Schnider, C; Jacobsen, H; Ozmen, L; Bergadano, A; Banner, DW; Hochstrasser, R; Kuglstatter, A; David-Pierson, P; Fischer, H; Polara, A; Narquizian, R	F. Hoffmann-La Roche Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432599&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			53241151	164161474		CHEMBL2347209				ZINC95601757	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486200	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C16H19F2N3O3/c1-21-14(22)12-6-10(7-23-2)24-8-16(12,20-15(21)19)11-4-3-9(17)5-13(11)18/h3-5,10,12H,6-8H2,1-2H3,(H2,19,20)/t10-,12+,16-/m1/s1	ZSTDDUYXLHRAMA-RSAASHCRSA-N	227968	US10047098, 1	Beta-secretase 2		 237						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227968&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331641	374884908							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486202	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(ccn2)C#N)c(F)cc1F	InChI=1S/C22H21F2N5O4/c1-29-20(30)15-6-13(10-31-2)32-11-22(15,28-21(29)26)14-7-18(17(24)8-16(14)23)33-19-5-12(9-25)3-4-27-19/h3-5,7-8,13,15H,6,10-11H2,1-2H3,(H2,26,28)/t13-,15+,22-/m1/s1	AHGJFIJKACDGHF-QOAZOABKSA-N	227969	US10047098, 2	Beta-secretase 2		 11.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227969&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473737	374884909							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486204	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncccc2F)c(F)cc1F	InChI=1S/C21H21F3N4O4/c1-28-19(29)13-6-11(9-30-2)31-10-21(13,27-20(28)25)12-7-17(16(24)8-15(12)23)32-18-14(22)4-3-5-26-18/h3-5,7-8,11,13H,6,9-10H2,1-2H3,(H2,25,27)/t11-,13+,21-/m1/s1	DPUFKFOVJMFSFY-FKQSZABXSA-N	227970	US10047098, 3	Beta-secretase 2		 3.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227970&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331666	374884910							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486206	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(OC)ccn2)c(F)cc1F	InChI=1S/C22H24F2N4O5/c1-28-20(29)15-6-13(10-30-2)32-11-22(15,27-21(28)25)14-8-18(17(24)9-16(14)23)33-19-7-12(31-3)4-5-26-19/h4-5,7-9,13,15H,6,10-11H2,1-3H3,(H2,25,27)/t13-,15+,22-/m1/s1	VEFPFUWXGCRWJT-QOAZOABKSA-N	227971	US10047098, 4	Beta-secretase 2		 61.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227971&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473695	374884911							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486210	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1ccc(F)cc1F	InChI=1S/C17H19F2N3O2/c1-22-15(23)12-7-14(9-2-3-9)24-8-17(12,21-16(22)20)11-5-4-10(18)6-13(11)19/h4-6,9,12,14H,2-3,7-8H2,1H3,(H2,20,21)/t12-,14+,17+/m0/s1	WORKKXMFZKXEBZ-DXCKQFNASA-N	227974	US10047098, 6	Beta-secretase 2		 265						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227974&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473676	374884914							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486212	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C(F)F)c1ccc(F)cc1F	InChI=1S/C15H15F4N3O2/c1-22-13(23)9-5-11(12(18)19)24-6-15(9,21-14(22)20)8-3-2-7(16)4-10(8)17/h2-4,9,11-12H,5-6H2,1H3,(H2,20,21)/t9-,11+,15+/m0/s1	KLDYYVMZIHWOGO-ZVWUFJHRSA-N	227975	US10047098, 7	Beta-secretase 2		 254						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227975&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473589	374884915							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486214	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)c1cc(C)no1)c1cc(F)ccc1F	InChI=1S/C18H18F2N4O3/c1-9-5-15(27-23-9)14-7-12-16(25)24(2)17(21)22-18(12,8-26-14)11-6-10(19)3-4-13(11)20/h3-6,12,14H,7-8H2,1-2H3,(H2,21,22)/t12-,14+,18+/m0/s1	YSCBUXLXXGLHGV-WPKBUWHJSA-N	227976	US10047098, 8	Beta-secretase 2		 34.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227976&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473590	374884916							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486216	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(ccn2)C#N)c(F)cc1F	InChI=1S/C21H19F2N5O3/c1-11-5-14-19(29)28(2)20(25)27-21(14,10-30-11)13-7-17(16(23)8-15(13)22)31-18-6-12(9-24)3-4-26-18/h3-4,6-8,11,14H,5,10H2,1-2H3,(H2,25,27)/t11-,14-,21+/m0/s1	PWNMHRVQZBYILN-YLTSQODRSA-N	227977	US10047098, 9	Beta-secretase 2		 4.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227977&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473586	374884917							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486218	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncccc2F)c(F)cc1F	InChI=1S/C20H19F3N4O3/c1-10-6-12-18(28)27(2)19(24)26-20(12,9-29-10)11-7-16(15(23)8-14(11)22)30-17-13(21)4-3-5-25-17/h3-5,7-8,10,12H,6,9H2,1-2H3,(H2,24,26)/t10-,12-,20+/m0/s1	URORKUMOZRGJRM-GXUQNELRSA-N	227978	US10047098, 10	Beta-secretase 2		 2.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227978&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331809	374884918							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486220	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C15H17F2N3O2/c1-8-5-11-13(21)20(2)14(18)19-15(11,7-22-8)10-4-3-9(16)6-12(10)17/h3-4,6,8,11H,5,7H2,1-2H3,(H2,18,19)/t8-,11-,15+/m0/s1	SFPZMGVJWZNXQD-PEGZWESCSA-N	227979	US10047098, 11	Beta-secretase 2		 105						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227979&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473581	374884919							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486222	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Br)ccc1F	InChI=1S/C15H17BrFN3O2/c1-8-5-11-13(21)20(2)14(18)19-15(11,7-22-8)10-6-9(16)3-4-12(10)17/h3-4,6,8,11H,5,7H2,1-2H3,(H2,18,19)/t8-,11-,15+/m0/s1	LKCAELLRAREUBA-PEGZWESCSA-N	227980	US10047098, 12	Beta-secretase 2		 125						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227980&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473735	374884920							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486226	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C23H22FN5O3/c1-29-21(30)17-10-19(14-2-3-14)31-12-23(17,28-22(29)26)16-9-15(4-5-18(16)24)32-20-8-13(11-25)6-7-27-20/h4-9,14,17,19H,2-3,10,12H2,1H3,(H2,26,28)/t17-,19+,23+/m0/s1	RMQDVPITFBMMSZ-GEQKSPFYSA-N	227982	US10047098, 14	Beta-secretase 2		 13.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227982&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473731	374884922							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486228	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C22H22F2N4O3/c1-28-20(29)15-10-18(12-4-5-12)30-11-22(15,27-21(28)25)14-9-13(6-7-16(14)23)31-19-17(24)3-2-8-26-19/h2-3,6-9,12,15,18H,4-5,10-11H2,1H3,(H2,25,27)/t15-,18+,22+/m0/s1	LJECMCKNCBEXLI-QXATTWAWSA-N	227983	US10047098, 15	Beta-secretase 2		 8.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227983&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331345	374884923							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486230	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ccnc(c2)-n2cncn2)ccc1F	InChI=1S/C24H24FN7O3/c1-31-22(33)18-10-20(14-2-3-14)34-11-24(18,30-23(31)26)17-8-15(4-5-19(17)25)35-16-6-7-28-21(9-16)32-13-27-12-29-32/h4-9,12-14,18,20H,2-3,10-11H2,1H3,(H2,26,30)/t18-,20+,24+/m0/s1	QOKJSKLGOKNOFU-MFSJNOQSSA-N	227984	US10047098, 16	Beta-secretase 2		 42.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227984&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473730	374884924							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486232	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cncc(C)n2)ccc1F	InChI=1S/C22H24FN5O3/c1-12-9-25-10-19(26-12)31-14-5-6-17(23)15(7-14)22-11-30-18(13-3-4-13)8-16(22)20(29)28(2)21(24)27-22/h5-7,9-10,13,16,18H,3-4,8,11H2,1-2H3,(H2,24,27)/t16-,18+,22+/m0/s1	OUMDSJCHVFFIET-AQOAWAETSA-N	227985	US10047098, 17	Beta-secretase 2		 102						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227985&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473740	374884925							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486234	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C22H21F3N4O3/c1-29-20(30)15-8-18(11-2-3-11)31-10-22(15,28-21(29)26)14-7-13(4-5-16(14)24)32-19-17(25)6-12(23)9-27-19/h4-7,9,11,15,18H,2-3,8,10H2,1H3,(H2,26,28)/t15-,18+,22+/m0/s1	AMGVHZXWRAGKDW-QXATTWAWSA-N	227986	US10047098, 18	Beta-secretase 2		 109						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227986&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473741	374884926							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486236	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C20H20F2N4O3/c1-11-8-14-18(27)26(2)19(23)25-20(14,10-28-11)13-9-12(5-6-15(13)21)29-17-16(22)4-3-7-24-17/h3-7,9,11,14H,8,10H2,1-2H3,(H2,23,25)/t11-,14-,20+/m0/s1	GDTFUUSWOQATGB-UHBVIIIMSA-N	227987	US10047098, 19	Beta-secretase 2		 5.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227987&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473742	374884927							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486238	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ccnc(c2)C(F)F)ccc1F	InChI=1S/C23H23F3N4O3/c1-30-21(31)16-10-19(12-2-3-12)32-11-23(16,29-22(30)27)15-8-13(4-5-17(15)24)33-14-6-7-28-18(9-14)20(25)26/h4-9,12,16,19-20H,2-3,10-11H2,1H3,(H2,27,29)/t16-,19+,23+/m0/s1	LAJAZVRVPIQBGI-XKDCRVNJSA-N	227988	US10047098, 20	Beta-secretase 2		 228						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227988&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473743	374884928							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486240	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C21H20FN5O3/c1-12-7-16-19(28)27(2)20(24)26-21(16,11-29-12)15-9-14(3-4-17(15)22)30-18-8-13(10-23)5-6-25-18/h3-6,8-9,12,16H,7,11H2,1-2H3,(H2,24,26)/t12-,16-,21+/m0/s1	SJELKKVCITZMQX-LBJGKRIESA-N	227989	US10047098, 21	Beta-secretase 2		 6.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227989&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473738	374884929							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486242	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ccnc(C)n2)ccc1F	InChI=1S/C22H24FN5O3/c1-12-25-8-7-19(26-12)31-14-5-6-17(23)15(9-14)22-11-30-18(13-3-4-13)10-16(22)20(29)28(2)21(24)27-22/h5-9,13,16,18H,3-4,10-11H2,1-2H3,(H2,24,27)/t16-,18+,22+/m0/s1	JVIROZAKFRONKD-AQOAWAETSA-N	227990	US10047098, 22	Beta-secretase 2		 182						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227990&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473745	374884930							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486244	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(OCC2CC2)ccc1F	InChI=1S/C19H24FN3O3/c1-11-7-15-17(24)23(2)18(21)22-19(15,10-26-11)14-8-13(5-6-16(14)20)25-9-12-3-4-12/h5-6,8,11-12,15H,3-4,7,9-10H2,1-2H3,(H2,21,22)/t11-,15-,19+/m0/s1	XHTUJRHTDXVYCK-SGJUXQJHSA-N	227991	US10047098, 23::US10047098, 92	Beta-secretase 2		 8.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227991&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473434	374884931							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486246	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC2CC2)ccc1F	InChI=1S/C21H26FN3O3/c1-25-19(26)16-9-18(13-4-5-13)28-11-21(16,24-20(25)23)15-8-14(6-7-17(15)22)27-10-12-2-3-12/h6-8,12-13,16,18H,2-5,9-11H2,1H3,(H2,23,24)/t16-,18+,21+/m0/s1	OWGBQKKKRZVLLM-YRISNDGFSA-N	227993	US10047098, 24	Beta-secretase 2		 10.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227993&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473427	374884933							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486248	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cccc(c2)C#N)ccc1F	InChI=1S/C24H23FN4O3/c1-29-22(30)19-11-21(15-5-6-15)31-13-24(19,28-23(29)27)18-10-17(7-8-20(18)25)32-16-4-2-3-14(9-16)12-26/h2-4,7-10,15,19,21H,5-6,11,13H2,1H3,(H2,27,28)/t19-,21+,24+/m0/s1	ONNIBYSFQOVAKA-XZDHIHRUSA-N	227994	US10047098, 25	Beta-secretase 2		 46.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227994&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473431	374884934							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486250	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(OCC23CC(C2)(C3)C#N)ccc1F	InChI=1S/C22H25FN4O3/c1-13-5-16-18(28)27(2)19(25)26-22(16,12-29-13)15-6-14(3-4-17(15)23)30-11-21-7-20(8-21,9-21)10-24/h3-4,6,13,16H,5,7-9,11-12H2,1-2H3,(H2,25,26)/t13-,16-,20?,21?,22+/m0/s1	HVCZHIZDKPIJER-CFTRSLMZSA-N	227995	US10047098, 26	Beta-secretase 2		 98.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227995&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473428	374884935							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486252	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cncc(c2)C#N)ccc1F	InChI=1S/C23H22FN5O3/c1-29-21(30)18-8-20(14-2-3-14)31-12-23(18,28-22(29)26)17-7-15(4-5-19(17)24)32-16-6-13(9-25)10-27-11-16/h4-7,10-11,14,18,20H,2-3,8,12H2,1H3,(H2,26,28)/t18-,20+,23+/m0/s1	SHCRILHOSNODGR-JXHRLWIKSA-N	227996	US10047098, 27	Beta-secretase 2		 51.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227996&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473732	374884936							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486254	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(ccc1F)-c1cncnc1	InChI=1S/C21H22FN5O2/c1-27-19(28)16-7-18(12-2-3-12)29-10-21(16,26-20(27)23)15-6-13(4-5-17(15)22)14-8-24-11-25-9-14/h4-6,8-9,11-12,16,18H,2-3,7,10H2,1H3,(H2,23,26)/t16-,18+,21+/m0/s1	LTXGFFXQSKLSPS-YRISNDGFSA-N	227997	US10047098, 28	Beta-secretase 2		 627						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227997&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462408	374884937							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486256	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cncc(n2)C(F)F)ccc1F	InChI=1S/C22H22F3N5O3/c1-30-20(31)14-7-17(11-2-3-11)32-10-22(14,29-21(30)26)13-6-12(4-5-15(13)23)33-18-9-27-8-16(28-18)19(24)25/h4-6,8-9,11,14,17,19H,2-3,7,10H2,1H3,(H2,26,29)/t14-,17+,22+/m0/s1	MPTZEBVFNVJXDP-WTBBCNCBSA-N	227999	US10047098, 29	Beta-secretase 2		 54.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227999&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473728	374884939							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486258	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C22H22FN5O4/c1-28-20(29)17-9-15(11-30-2)31-12-22(17,27-21(28)25)16-8-14(3-4-18(16)23)32-19-7-13(10-24)5-6-26-19/h3-8,15,17H,9,11-12H2,1-2H3,(H2,25,27)/t15-,17+,22-/m1/s1	SEDSCYCTKHCWOK-ULYRPOKDSA-N	228000	US10047098, 30	Beta-secretase 2		 25.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228000&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473733	374884940							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486260	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C21H22F2N4O4/c1-27-19(28)15-9-13(10-29-2)30-11-21(15,26-20(27)24)14-8-12(5-6-16(14)22)31-18-17(23)4-3-7-25-18/h3-8,13,15H,9-11H2,1-2H3,(H2,24,26)/t13-,15+,21-/m1/s1	XJKFDLWEBWQJNA-VWVPQACVSA-N	228001	US10047098, 31	Beta-secretase 2		 8.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228001&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473583	374884941							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486262	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(OCC2CC2)ccc1F	InChI=1S/C20H26FN3O4/c1-24-18(25)16-8-14(10-26-2)28-11-20(16,23-19(24)22)15-7-13(5-6-17(15)21)27-9-12-3-4-12/h5-7,12,14,16H,3-4,8-11H2,1-2H3,(H2,22,23)/t14-,16+,20-/m1/s1	MHJRFSUXUKZQFM-PTSWNOGYSA-N	228002	US10047098, 32::US10047098, 90	Beta-secretase 2		 9.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228002&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473580	374884942							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486264	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Br)ccc1F	InChI=1S/C16H19BrFN3O3/c1-21-14(22)12-6-10(7-23-2)24-8-16(12,20-15(21)19)11-5-9(17)3-4-13(11)18/h3-5,10,12H,6-8H2,1-2H3,(H2,19,20)/t10-,12+,16-/m1/s1	ALMVURYVJCETEZ-RSAASHCRSA-N	228003	US10047098, 33::US10047098, 89	Beta-secretase 2		 304						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228003&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462151	374884943							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486266	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cccc(n2)-n2cccn2)ccc1F	InChI=1S/C25H25FN6O3/c1-31-23(33)18-13-20(15-6-7-15)34-14-25(18,30-24(31)27)17-12-16(8-9-19(17)26)35-22-5-2-4-21(29-22)32-11-3-10-28-32/h2-5,8-12,15,18,20H,6-7,13-14H2,1H3,(H2,27,30)/t18-,20+,25+/m0/s1	JZALFYMKSGBBQK-DMJCMNNJSA-N	228006	US10047098, 34	Beta-secretase 2		 13.5						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228006&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462583	374884944							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486268	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cccc(c2)-c2cocn2)ccc1F	InChI=1S/C26H25FN4O4/c1-31-24(32)20-11-23(15-5-6-15)34-13-26(20,30-25(31)28)19-10-18(7-8-21(19)27)35-17-4-2-3-16(9-17)22-12-33-14-29-22/h2-4,7-10,12,14-15,20,23H,5-6,11,13H2,1H3,(H2,28,30)/t20-,23+,26+/m0/s1	ZTCFAYGMXHYGOE-VAPDBKPJSA-N	228007	US10047098, 35	Beta-secretase 2		 86.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228007&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462561	374884945							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486270	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C20H19F3N4O3/c1-10-5-14-18(28)27(2)19(24)26-20(14,9-29-10)13-7-12(3-4-15(13)22)30-17-16(23)6-11(21)8-25-17/h3-4,6-8,10,14H,5,9H2,1-2H3,(H2,24,26)/t10-,14-,20+/m0/s1	OCDQCVOMXQIOQL-ZNUZLIQOSA-N	228008	US10047098, 36::US10047098, 79	Beta-secretase 2		 24.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228008&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473744	374884946							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486272	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC23CC(C2)(C3)C#N)ccc1F	InChI=1S/C24H27FN4O3/c1-29-20(30)17-7-19(14-2-3-14)32-13-24(17,28-21(29)27)16-6-15(4-5-18(16)25)31-12-23-8-22(9-23,10-23)11-26/h4-6,14,17,19H,2-3,7-10,12-13H2,1H3,(H2,27,28)/t17-,19+,22?,23?,24+/m0/s1	UMJLKSFEAGVNAX-GGQLVBMXSA-N	228009	US10047098, 37	Beta-secretase 2		 127						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228009&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473746	374884947							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486274	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(ccc1F)C#N	InChI=1S/C18H19FN4O2/c1-23-16(24)13-7-15(11-3-4-11)25-9-18(13,22-17(23)21)12-6-10(8-20)2-5-14(12)19/h2,5-6,11,13,15H,3-4,7,9H2,1H3,(H2,21,22)/t13-,15+,18+/m0/s1	WGWMVBFIFOTEES-JCKWVBRZSA-N	228010	US10047098, 38	Beta-secretase 2		 398						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228010&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331715	374884948							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486276	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cnccn2)ccc1F	InChI=1S/C21H22FN5O3/c1-27-19(28)15-9-17(12-2-3-12)29-11-21(15,26-20(27)23)14-8-13(4-5-16(14)22)30-18-10-24-6-7-25-18/h4-8,10,12,15,17H,2-3,9,11H2,1H3,(H2,23,26)/t15-,17+,21+/m0/s1	VKDFHCGFHOAGDV-LUQKVYGDSA-N	228011	US10047098, 39	Beta-secretase 2		 73.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228011&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331452	374884949							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486278	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ccncc2)ccc1F	InChI=1S/C22H23FN4O3/c1-27-20(28)17-11-19(13-2-3-13)29-12-22(17,26-21(27)24)16-10-15(4-5-18(16)23)30-14-6-8-25-9-7-14/h4-10,13,17,19H,2-3,11-12H2,1H3,(H2,24,26)/t17-,19+,22+/m0/s1	IMEOUUXECCTHGS-LRXVAGHRSA-N	228012	US10047098, 40	Beta-secretase 2		 11.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228012&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473615	374884950							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486280	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ccnnc2)ccc1F	InChI=1S/C21H22FN5O3/c1-27-19(28)16-9-18(12-2-3-12)29-11-21(16,26-20(27)23)15-8-13(4-5-17(15)22)30-14-6-7-24-25-10-14/h4-8,10,12,16,18H,2-3,9,11H2,1H3,(H2,23,26)/t16-,18+,21+/m0/s1	ZAHJIHACZITMNN-YRISNDGFSA-N	228013	US10047098, 41	Beta-secretase 2		 65.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228013&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473616	374884951							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486282	COc1cncc(Oc2ccc(F)c(c2)[C@]23CO[C@H](C[C@H]2C(=O)N(C)C(=N)N3)C2CC2)n1	InChI=1S/C22H24FN5O4/c1-28-20(29)15-8-17(12-3-4-12)31-11-22(15,27-21(28)24)14-7-13(5-6-16(14)23)32-19-10-25-9-18(26-19)30-2/h5-7,9-10,12,15,17H,3-4,8,11H2,1-2H3,(H2,24,27)/t15-,17+,22+/m0/s1	GBFSOMOOYFFZFW-LBUQITIBSA-N	228014	US10047098, 42	Beta-secretase 2		 51.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228014&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462619	374884952							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486284	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ncccn2)ccc1F	InChI=1S/C21H22FN5O3/c1-27-18(28)15-10-17(12-3-4-12)29-11-21(15,26-19(27)23)14-9-13(5-6-16(14)22)30-20-24-7-2-8-25-20/h2,5-9,12,15,17H,3-4,10-11H2,1H3,(H2,23,26)/t15-,17+,21+/m0/s1	SXBDKZSAVIKRML-LUQKVYGDSA-N	228015	US10047098, 43	Beta-secretase 2		 191						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228015&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473617	374884953							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486286	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC2CCC2)ccc1F	InChI=1S/C22H28FN3O3/c1-26-20(27)17-10-19(14-5-6-14)29-12-22(17,25-21(26)24)16-9-15(7-8-18(16)23)28-11-13-3-2-4-13/h7-9,13-14,17,19H,2-6,10-12H2,1H3,(H2,24,25)/t17-,19+,22+/m0/s1	RPALTLKKQSHUIW-LRXVAGHRSA-N	228017	US10047098, 44	Beta-secretase 2		 20.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228017&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473618	374884955							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486288	CC(C)COc1ccc(F)c(c1)[C@]12CO[C@H](C[C@H]1C(=O)N(C)C(=N)N2)C1CC1	InChI=1S/C21H28FN3O3/c1-12(2)10-27-14-6-7-17(22)15(8-14)21-11-28-18(13-4-5-13)9-16(21)19(26)25(3)20(23)24-21/h6-8,12-13,16,18H,4-5,9-11H2,1-3H3,(H2,23,24)/t16-,18+,21+/m0/s1	COGFGPSRPZHREO-YRISNDGFSA-N	228019	US10047098, 45	Beta-secretase 2		 25.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228019&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473454	374884957							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486290	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC(F)F)ccc1F	InChI=1S/C19H22F3N3O3/c1-25-17(26)13-7-15(10-2-3-10)28-9-19(13,24-18(25)23)12-6-11(4-5-14(12)20)27-8-16(21)22/h4-6,10,13,15-16H,2-3,7-9H2,1H3,(H2,23,24)/t13-,15+,19+/m0/s1	PWLVIVOCYSQWGJ-ZBQZNYHESA-N	228020	US10047098, 46	Beta-secretase 2		 41.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228020&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473443	374884958							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486292	COC[C@@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C16H19F2N3O3/c1-21-14(22)12-6-10(7-23-2)24-8-16(12,20-15(21)19)11-4-3-9(17)5-13(11)18/h3-5,10,12H,6-8H2,1-2H3,(H2,19,20)/t10-,12-,16+/m0/s1	ZSTDDUYXLHRAMA-KNHMANMVSA-N	228021	US10047098, 47	Beta-secretase 2		 9299						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228021&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473444	374884959							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486294	COC(=O)[C@@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C16H17F2N3O4/c1-21-13(22)10-6-12(14(23)24-2)25-7-16(10,20-15(21)19)9-4-3-8(17)5-11(9)18/h3-5,10,12H,6-7H2,1-2H3,(H2,19,20)/t10-,12-,16+/m0/s1	AXXJWDBVUZBQMA-KNHMANMVSA-N	228022	US10047098, 48	Beta-secretase 2		 1385						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228022&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473449	374884960							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486296	CCCOc1ccc(F)c(c1)[C@]12CO[C@H](C[C@H]1C(=O)N(C)C(=N)N2)C1CC1	InChI=1S/C20H26FN3O3/c1-3-8-26-13-6-7-16(21)14(9-13)20-11-27-17(12-4-5-12)10-15(20)18(25)24(2)19(22)23-20/h6-7,9,12,15,17H,3-5,8,10-11H2,1-2H3,(H2,22,23)/t15-,17+,20+/m0/s1	FZDLGVCJJOWLEU-XAUMDUMWSA-N	228023	US10047098, 49	Beta-secretase 2		 64.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228023&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331755	374884961							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486298	COCCOc1ccc(F)c(c1)[C@]12CO[C@H](C[C@H]1C(=O)N(C)C(=N)N2)C1CC1	InChI=1S/C20H26FN3O4/c1-24-18(25)15-10-17(12-3-4-12)28-11-20(15,23-19(24)22)14-9-13(5-6-16(14)21)27-8-7-26-2/h5-6,9,12,15,17H,3-4,7-8,10-11H2,1-2H3,(H2,22,23)/t15-,17+,20+/m0/s1	ZKQCIWVOCSLNMY-XAUMDUMWSA-N	228024	US10047098, 50	Beta-secretase 2		 68.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228024&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473596	374884962							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486300	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC2CC(F)(F)C2)ccc1F	InChI=1S/C22H26F3N3O3/c1-28-19(29)16-7-18(13-2-3-13)31-11-22(16,27-20(28)26)15-6-14(4-5-17(15)23)30-10-12-8-21(24,25)9-12/h4-6,12-13,16,18H,2-3,7-11H2,1H3,(H2,26,27)/t16-,18+,22+/m0/s1	COMJXCVCOJPHMX-AQOAWAETSA-N	228025	US10047098, 51	Beta-secretase 2		 42.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228025&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473591	374884963							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486302	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC2CC2(F)F)ccc1F	InChI=1S/C21H24F3N3O3/c1-27-18(28)15-7-17(11-2-3-11)30-10-20(15,26-19(27)25)14-6-13(4-5-16(14)22)29-9-12-8-21(12,23)24/h4-6,11-12,15,17H,2-3,7-10H2,1H3,(H2,25,26)/t12?,15-,17+,20+/m0/s1	ZNMXVXCOFTXNAL-GHRXZKGRSA-N	228026	US10047098, 52	Beta-secretase 2		 18.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228026&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462277	374884964							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486304	COC1CC(COc2ccc(F)c(c2)[C@]23CO[C@H](C[C@H]2C(=O)N(C)C(=N)N3)C2CC2)C1	InChI=1S/C23H30FN3O4/c1-27-21(28)18-10-20(14-3-4-14)31-12-23(18,26-22(27)25)17-9-15(5-6-19(17)24)30-11-13-7-16(8-13)29-2/h5-6,9,13-14,16,18,20H,3-4,7-8,10-12H2,1-2H3,(H2,25,26)/t13?,16?,18-,20+,23+/m0/s1	YFAUFWQOCWQQGA-OPECPVASSA-N	228027	US10047098, 53	Beta-secretase 2		 117						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228027&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473592	374884965							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486306	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC23CC(C2)C3)ccc1F	InChI=1S/C23H28FN3O3/c1-27-20(28)17-7-19(14-2-3-14)30-12-23(17,26-21(27)25)16-6-15(4-5-18(16)24)29-11-22-8-13(9-22)10-22/h4-6,13-14,17,19H,2-3,7-12H2,1H3,(H2,25,26)/t13?,17-,19+,22?,23+/m0/s1	HRCMDHXPZIIDQW-NLCLAXHPSA-N	228028	US10047098, 54	Beta-secretase 2		 4.00						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228028&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473597	374884966							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486308	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OCC(F)(F)F)ccc1F	InChI=1S/C19H21F4N3O3/c1-26-16(27)13-7-15(10-2-3-10)29-8-18(13,25-17(26)24)12-6-11(4-5-14(12)20)28-9-19(21,22)23/h4-6,10,13,15H,2-3,7-9H2,1H3,(H2,24,25)/t13-,15+,18+/m0/s1	NJPSRIKFWGSVNB-JCKWVBRZSA-N	228029	US10047098, 55	Beta-secretase 2		 4612						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228029&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473593	374884967							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486310	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2cc(ccn2)-n2cccn2)ccc1F	InChI=1S/C25H25FN6O3/c1-31-23(33)19-13-21(15-3-4-15)34-14-25(19,30-24(31)27)18-12-17(5-6-20(18)26)35-22-11-16(7-9-28-22)32-10-2-8-29-32/h2,5-12,15,19,21H,3-4,13-14H2,1H3,(H2,27,30)/t19-,21+,25+/m0/s1	FSWLLLVMFNJJOV-PIBDYAPNSA-N	228030	US10047098, 56	Beta-secretase 2		 51.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228030&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473623	374884968							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486312	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(OC2CC(F)(F)C2)ccc1F	InChI=1S/C21H24F3N3O3/c1-27-18(28)15-7-17(11-2-3-11)29-10-21(15,26-19(27)25)14-6-12(4-5-16(14)22)30-13-8-20(23,24)9-13/h4-6,11,13,15,17H,2-3,7-10H2,1H3,(H2,25,26)/t15-,17+,21+/m0/s1	OCGHEMXCNCCFCN-LUQKVYGDSA-N	228031	US10047098, 57	Beta-secretase 2		 41.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228031&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473620	374884969							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486314	CN1C(=N)N[C@]2(CO[C@H](CC2C1=O)C1CC1)c1cc(Oc2ncncc2F)ccc1F	InChI=1S/C21H21F2N5O3/c1-28-19(29)14-7-17(11-2-3-11)30-9-21(14,27-20(28)24)13-6-12(4-5-15(13)22)31-18-16(23)8-25-10-26-18/h4-6,8,10-11,14,17H,2-3,7,9H2,1H3,(H2,24,27)/t14?,17-,21-/m1/s1	FNEBTEGFFRVSOP-OOJFQMAISA-N	228032	US10047098, 58	Beta-secretase 2		 35.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228032&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331746	374884970							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486316	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(F)cnc2F)c(F)cc1F	InChI=1S/C21H20F4N4O4/c1-29-19(30)13-4-11(8-31-2)32-9-21(13,28-20(29)26)12-5-16(15(24)6-14(12)23)33-17-3-10(22)7-27-18(17)25/h3,5-7,11,13H,4,8-9H2,1-2H3,(H2,26,28)/t11-,13+,21-/m1/s1	MXWOYPFCWXGUAA-FKQSZABXSA-N	228033	US10047098, 59	Beta-secretase 2		 20.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228033&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462367	374884971							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486318	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C1CC1)c1cc(Oc2ncc(C)cc2F)ccc1F	InChI=1S/C23H24F2N4O3/c1-12-7-18(25)20(27-10-12)32-14-5-6-17(24)15(8-14)23-11-31-19(13-3-4-13)9-16(23)21(30)29(2)22(26)28-23/h5-8,10,13,16,19H,3-4,9,11H2,1-2H3,(H2,26,28)/t16-,19+,23+/m0/s1	UUODINZURHGQHB-XKDCRVNJSA-N	228034	US10047098, 60	Beta-secretase 2		 125						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228034&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473624	374884972							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486320	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)C(F)F)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C20H17F5N4O3/c1-29-18(30)12-6-15(16(24)25)31-8-20(12,28-19(29)26)11-5-10(2-3-13(11)22)32-17-14(23)4-9(21)7-27-17/h2-5,7,12,15-16H,6,8H2,1H3,(H2,26,28)/t12-,15+,20+/m0/s1	UDDVRYDFAFVYKC-PGICJIBASA-N	228035	US10047098, 61	Beta-secretase 2		 44.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228035	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228035&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473622	374884973							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486322	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(O)ccc1F	InChI=1S/C15H18FN3O3/c1-8-5-11-13(21)19(2)14(17)18-15(11,7-22-8)10-6-9(20)3-4-12(10)16/h3-4,6,8,11,20H,5,7H2,1-2H3,(H2,17,18)/t8-,11-,15+/m0/s1	KVRJDMCWWRIZGI-PEGZWESCSA-N	228036	US10047098, 64	Beta-secretase 2		 82.7						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228036&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86729411	374884974							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486324	COc1cncc(Oc2ccc(F)c(c2)[C@]23CO[C@@H](C)C[C@H]2C(=O)N(C)C(=N)N3)n1	InChI=1S/C20H22FN5O4/c1-11-6-14-18(27)26(2)19(22)25-20(14,10-29-11)13-7-12(4-5-15(13)21)30-17-9-23-8-16(24-17)28-3/h4-5,7-9,11,14H,6,10H2,1-3H3,(H2,22,25)/t11-,14-,20+/m0/s1	XVLOAAIDAZKWDR-UHBVIIIMSA-N	228037	US10047098, 65	Beta-secretase 2		 15.8						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228037&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86729413	374884975							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486326	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cnccn2)ccc1F	InChI=1S/C19H20FN5O3/c1-11-7-14-17(26)25(2)18(21)24-19(14,10-27-11)13-8-12(3-4-15(13)20)28-16-9-22-5-6-23-16/h3-6,8-9,11,14H,7,10H2,1-2H3,(H2,21,24)/t11-,14-,19+/m0/s1	PPOPRQRMXDLJFK-NXPJVHOHSA-N	228038	US10047098, 66	Beta-secretase 2		 30.3						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228038&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86729414	374884976							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486328	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cncc(C)n2)ccc1F	InChI=1S/C20H22FN5O3/c1-11-8-23-9-17(24-11)29-13-4-5-16(21)14(7-13)20-10-28-12(2)6-15(20)18(27)26(3)19(22)25-20/h4-5,7-9,12,15H,6,10H2,1-3H3,(H2,22,25)/t12-,15-,20+/m0/s1	XCYZCECBYYYMEH-NRKGENKXSA-N	228039	US10047098, 67	Beta-secretase 2		 25.2						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228039&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473598	374884977							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486330	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ccc(F)cn2)ccc1F	InChI=1S/C20H20F2N4O3/c1-11-7-15-18(27)26(2)19(23)25-20(15,10-28-11)14-8-13(4-5-16(14)22)29-17-6-3-12(21)9-24-17/h3-6,8-9,11,15H,7,10H2,1-2H3,(H2,23,25)/t11-,15-,20+/m0/s1	OKTSVCWCQOMADW-UYHHGJEOSA-N	228040	US10047098, 68	Beta-secretase 2		 71.3						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228040&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86729415	374884978							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486332	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncncc2F)ccc1F	InChI=1S/C19H19F2N5O3/c1-10-5-13-17(27)26(2)18(22)25-19(13,8-28-10)12-6-11(3-4-14(12)20)29-16-15(21)7-23-9-24-16/h3-4,6-7,9-10,13H,5,8H2,1-2H3,(H2,22,25)/t10-,13-,19+/m0/s1	FYRKOIOLQIQLEH-WSHAHDTKSA-N	228041	US10047098, 69	Beta-secretase 2		 6.78						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228041	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228041&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462244	374884979							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486334	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2nccnc2C)ccc1F	InChI=1S/C20H22FN5O3/c1-11-8-15-18(27)26(3)19(22)25-20(15,10-28-11)14-9-13(4-5-16(14)21)29-17-12(2)23-6-7-24-17/h4-7,9,11,15H,8,10H2,1-3H3,(H2,22,25)/t11-,15-,20+/m0/s1	KWMKTUUNBHQYMA-UYHHGJEOSA-N	228042	US10047098, 70	Beta-secretase 2		 235						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228042&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462057	374884980							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486336	COc1ccnc(Oc2ccc(F)c(c2)[C@]23CO[C@@H](C)C[C@H]2C(=O)N(C)C(=N)N3)c1	InChI=1S/C21H23FN4O4/c1-12-8-16-19(27)26(2)20(23)25-21(16,11-29-12)15-9-14(4-5-17(15)22)30-18-10-13(28-3)6-7-24-18/h4-7,9-10,12,16H,8,11H2,1-3H3,(H2,23,25)/t12-,16-,21+/m0/s1	VXJSYEVMQIHXJU-LBJGKRIESA-N	228043	US10047098, 71	Beta-secretase 2		 15.0						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228043&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462528	374884981							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486338	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncccc2Cl)ccc1F	InChI=1S/C20H20ClFN4O3/c1-11-8-14-18(27)26(2)19(23)25-20(14,10-28-11)13-9-12(5-6-16(13)22)29-17-15(21)4-3-7-24-17/h3-7,9,11,14H,8,10H2,1-2H3,(H2,23,25)/t11-,14-,20+/m0/s1	MPMYXKPWNXPHGK-UHBVIIIMSA-N	228044	US10047098, 72	Beta-secretase 2		 9.67						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228044&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462398	375076987							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486340	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncccc2C)ccc1F	InChI=1S/C21H23FN4O3/c1-12-5-4-8-24-18(12)29-14-6-7-17(22)15(10-14)21-11-28-13(2)9-16(21)19(27)26(3)20(23)25-21/h4-8,10,13,16H,9,11H2,1-3H3,(H2,23,25)/t13-,16-,21+/m0/s1	DLAYSYYSFHNTLY-UYTHQXMGSA-N	228045	US10047098, 73	Beta-secretase 2		 32.3						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228045&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473626	375076988							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486342	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ccncc2F)ccc1F	InChI=1S/C20H20F2N4O3/c1-11-7-14-18(27)26(2)19(23)25-20(14,10-28-11)13-8-12(3-4-15(13)21)29-17-5-6-24-9-16(17)22/h3-6,8-9,11,14H,7,10H2,1-2H3,(H2,23,25)/t11-,14-,20+/m0/s1	BTRBKDUNBZYNMZ-UHBVIIIMSA-N	228046	US10047098, 74	Beta-secretase 2		 31.5						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228046&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462502	375076989							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486344	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cnccc2Cl)ccc1F	InChI=1S/C20H20ClFN4O3/c1-11-7-14-18(27)26(2)19(23)25-20(14,10-28-11)13-8-12(3-4-16(13)22)29-17-9-24-6-5-15(17)21/h3-6,8-9,11,14H,7,10H2,1-2H3,(H2,23,25)/t11-,14-,20+/m0/s1	CAKNGAICVGTTOJ-UHBVIIIMSA-N	228047	US10047098, 75	Beta-secretase 2		 23.3						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228047&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462058	375076990							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486346	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ccccn2)ccc1F	InChI=1S/C20H21FN4O3/c1-12-9-15-18(26)25(2)19(22)24-20(15,11-27-12)14-10-13(6-7-16(14)21)28-17-5-3-4-8-23-17/h3-8,10,12,15H,9,11H2,1-2H3,(H2,22,24)/t12-,15-,20+/m0/s1	APEGKTYHDHGMKK-NRKGENKXSA-N	228048	US10047098, 76	Beta-secretase 2		 13.4						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228048&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462215	375076991							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486348	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc3ccccc3cn2)ccc1F	InChI=1S/C24H23FN4O3/c1-14-9-19-22(30)29(2)23(26)28-24(19,13-31-14)18-11-17(7-8-20(18)25)32-21-10-15-5-3-4-6-16(15)12-27-21/h3-8,10-12,14,19H,9,13H2,1-2H3,(H2,26,28)/t14-,19-,24+/m0/s1	HNIYAYQXHSUWDI-BSTGMLCMSA-N	228049	US10047098, 77	Beta-secretase 2		 242						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228049&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473455	375076992							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486350	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cncc(F)c2)ccc1F	InChI=1S/C20H20F2N4O3/c1-11-5-16-18(27)26(2)19(23)25-20(16,10-28-11)15-7-13(3-4-17(15)22)29-14-6-12(21)8-24-9-14/h3-4,6-9,11,16H,5,10H2,1-2H3,(H2,23,25)/t11-,16-,20+/m0/s1	OIYMHMGKTPNAPS-XITNVPRNSA-N	228050	US10047098, 78	Beta-secretase 2		 32.9						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228050&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462214	375076993							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486352	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C20H19F3N4O3/c1-10-5-14-18(28)27(2)19(24)26-20(14,9-29-10)13-7-12(3-4-15(13)22)30-17-16(23)6-11(21)8-25-17/h3-4,6-8,10,14H,5,9H2,1-2H3,(H2,24,26)/t10-,14-,20+/m0/s1	OCDQCVOMXQIOQL-ZNUZLIQOSA-N	228008	US10047098, 36::US10047098, 79	Beta-secretase 2		 41.3						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228008&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473744	374884946							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486354	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(F)cnc2F)ccc1F	InChI=1S/C20H19F3N4O3/c1-10-5-14-18(28)27(2)19(24)26-20(14,9-29-10)13-7-12(3-4-15(13)22)30-16-6-11(21)8-25-17(16)23/h3-4,6-8,10,14H,5,9H2,1-2H3,(H2,24,26)/t10-,14-,20+/m0/s1	OMWGOLGOTCVVQB-ZNUZLIQOSA-N	228052	US10047098, 80	Beta-secretase 2		 22.3						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228052&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473537	375076995							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486356	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cccnc2)ccc1F	InChI=1S/C20H21FN4O3/c1-12-8-16-18(26)25(2)19(22)24-20(16,11-27-12)15-9-13(5-6-17(15)21)28-14-4-3-7-23-10-14/h3-7,9-10,12,16H,8,11H2,1-2H3,(H2,22,24)/t12-,16-,20+/m0/s1	GIQNJTDYMYDSED-SLSDUTBNSA-N	228053	US10047098, 81	Beta-secretase 2		 20.7						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228053&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462279	375076996							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486358	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2cc(F)ccc2F)ccc1F	InChI=1S/C21H20F3N3O3/c1-11-7-15-19(28)27(2)20(25)26-21(15,10-29-11)14-9-13(4-6-16(14)23)30-18-8-12(22)3-5-17(18)24/h3-6,8-9,11,15H,7,10H2,1-2H3,(H2,25,26)/t11-,15-,21+/m0/s1	ROOLSEHAGCDPSC-DQLGPHAMSA-N	228054	US10047098, 82	Beta-secretase 2		 23.5						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228054&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462208	375076997							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486360	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)c1ccc(F)cc1)c1cc(Br)ccc1F	InChI=1S/C20H18BrF2N3O2/c1-26-18(27)15-9-17(11-2-5-13(22)6-3-11)28-10-20(15,25-19(26)24)14-8-12(21)4-7-16(14)23/h2-8,15,17H,9-10H2,1H3,(H2,24,25)/t15-,17+,20+/m0/s1	SKZDRYFHZBARIE-XAUMDUMWSA-N	228055	US10047098, 83	Beta-secretase 2		 24.2						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228055&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473543	375076998							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486362	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)c1ccc(F)cc1)c1cc(O)ccc1F	InChI=1S/C20H19F2N3O3/c1-25-18(27)15-9-17(11-2-4-12(21)5-3-11)28-10-20(15,24-19(25)23)14-8-13(26)6-7-16(14)22/h2-8,15,17,26H,9-10H2,1H3,(H2,23,24)/t15-,17+,20+/m0/s1	FNVRKZGZEPXWMJ-XAUMDUMWSA-N	228056	US10047098, 84	Beta-secretase 2		 17.2						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228056&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462281	375076999							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486364	CN1C(=N)N[C@]2(CO[C@H](C[C@H]2C1=O)c1ccc(F)cc1)c1cc(OCC2CC2)ccc1F	InChI=1S/C24H25F2N3O3/c1-29-22(30)19-11-21(15-4-6-16(25)7-5-15)32-13-24(19,28-23(29)27)18-10-17(8-9-20(18)26)31-12-14-2-3-14/h4-10,14,19,21H,2-3,11-13H2,1H3,(H2,27,28)/t19-,21+,24+/m0/s1	OREYUDLTBQMRAY-XZDHIHRUSA-N	228057	US10047098, 85	Beta-secretase 2		 0.760						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228057&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462285	375077000							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486366	CN1C(=N)N[C@]2(COCC[C@H]2C1=O)c1cc(Br)ccc1F	InChI=1S/C14H15BrFN3O2/c1-19-12(20)9-4-5-21-7-14(9,18-13(19)17)10-6-8(15)2-3-11(10)16/h2-3,6,9H,4-5,7H2,1H3,(H2,17,18)/t9-,14-/m0/s1	MPURLLWZGNOYII-XPTSAGLGSA-N	228058	US10047098, 86	Beta-secretase 2		 298						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228058&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473451	375077001							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486368	CN1C(=N)N[C@]2(COCC[C@H]2C1=O)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C19H18F2N4O3/c1-25-17(26)12-6-8-27-10-19(12,24-18(25)22)13-9-11(4-5-14(13)20)28-16-15(21)3-2-7-23-16/h2-5,7,9,12H,6,8,10H2,1H3,(H2,22,24)/t12-,19-/m0/s1	KDBMQQCRDVDADY-BUXKBTBVSA-N	228059	US10047098, 87	Beta-secretase 2		 13.5						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228059&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473452	375077002							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486370	CN1C(=N)N[C@]2(COCC[C@H]2C1=O)c1cc(OCC2CC2)ccc1F	InChI=1S/C18H22FN3O3/c1-22-16(23)13-6-7-24-10-18(13,21-17(22)20)14-8-12(4-5-15(14)19)25-9-11-2-3-11/h4-5,8,11,13H,2-3,6-7,9-10H2,1H3,(H2,20,21)/t13-,18-/m0/s1	BMOQAXVOVWGXHF-UGSOOPFHSA-N	228060	US10047098, 88	Beta-secretase 2		 5.96						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228060&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473453	375077003							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486372	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Br)ccc1F	InChI=1S/C16H19BrFN3O3/c1-21-14(22)12-6-10(7-23-2)24-8-16(12,20-15(21)19)11-5-9(17)3-4-13(11)18/h3-5,10,12H,6-8H2,1-2H3,(H2,19,20)/t10-,12+,16-/m1/s1	ALMVURYVJCETEZ-RSAASHCRSA-N	228003	US10047098, 33::US10047098, 89	Beta-secretase 2		 304						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228003&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462151	374884943							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486374	COC[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(OCC2CC2)ccc1F	InChI=1S/C20H26FN3O4/c1-24-18(25)16-8-14(10-26-2)28-11-20(16,23-19(24)22)15-7-13(5-6-17(15)21)27-9-12-3-4-12/h5-7,12,14,16H,3-4,8-11H2,1-2H3,(H2,22,23)/t14-,16+,20-/m1/s1	MHJRFSUXUKZQFM-PTSWNOGYSA-N	228002	US10047098, 32::US10047098, 90	Beta-secretase 2		 8.84						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228002&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473580	374884942							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486376	COc1cc(c(F)cn1)[C@]12CO[C@@H](C)C[C@H]1C(=O)N(C)C(=N)N2	InChI=1S/C15H19FN4O3/c1-8-4-10-13(21)20(2)14(17)19-15(10,7-23-8)9-5-12(22-3)18-6-11(9)16/h5-6,8,10H,4,7H2,1-3H3,(H2,17,19)/t8-,10-,15+/m0/s1	XSKBYVFOMBLZTA-KPWYMIHSSA-N	228063	US10047098, 91	Beta-secretase 2		 155						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228063	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228063&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			90331801	375077006							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486378	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(OCC2CC2)ccc1F	InChI=1S/C19H24FN3O3/c1-11-7-15-17(24)23(2)18(21)22-19(15,10-26-11)14-8-13(5-6-16(14)20)25-9-12-3-4-12/h5-6,8,11-12,15H,3-4,7,9-10H2,1-2H3,(H2,21,22)/t11-,15-,19+/m0/s1	XHTUJRHTDXVYCK-SGJUXQJHSA-N	227991	US10047098, 23::US10047098, 92	Beta-secretase 2		 2.19						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227991&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473434	374884931							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486380	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(OCCC=C)ncc1F	InChI=1S/C18H23FN4O3/c1-4-5-6-25-15-8-12(14(19)9-21-15)18-10-26-11(2)7-13(18)16(24)23(3)17(20)22-18/h4,8-9,11,13H,1,5-7,10H2,2-3H3,(H2,20,22)/t11-,13-,18+/m0/s1	PDYDILSFAGHKRH-RRUGBERISA-N	228065	US10047098, 93	Beta-secretase 2		 4.46						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228065	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228065&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473547	375077008							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486382	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(=O)n(CC2CC2)cc1F	InChI=1S/C18H23FN4O3/c1-10-5-13-16(25)22(2)17(20)21-18(13,9-26-10)12-6-15(24)23(8-14(12)19)7-11-3-4-11/h6,8,10-11,13H,3-5,7,9H2,1-2H3,(H2,20,21)/t10-,13-,18+/m0/s1	JMHCSDPMHNNNMA-OGJWQKAUSA-N	228066	US10047098, 94	Beta-secretase 2		 1588						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228066&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473548	375077009							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486384	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(=O)n(CCC=C)cc1F	InChI=1S/C18H23FN4O3/c1-4-5-6-23-9-14(19)12(8-15(23)24)18-10-26-11(2)7-13(18)16(25)22(3)17(20)21-18/h4,8-9,11,13H,1,5-7,10H2,2-3H3,(H2,20,21)/t11-,13-,18+/m0/s1	UVNMRTMDDORJBS-RRUGBERISA-N	228067	US10047098, 95	Beta-secretase 2		 1594						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228067&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89473673	375077010							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
486386	C[C@H]1C[C@H]2C(=O)N(C)C(=N)N[C@]2(CO1)c1cc(Oc2ncccc2F)ncc1F	InChI=1S/C19H19F2N5O3/c1-10-6-12-17(27)26(2)18(22)25-19(12,9-28-10)11-7-15(24-8-14(11)21)29-16-13(20)4-3-5-23-16/h3-5,7-8,10,12H,6,9H2,1-2H3,(H2,22,25)/t10-,12-,19+/m0/s1	MLIDTEFWYFWTME-MAZUYXTBSA-N	228068	US10047098, 96	Beta-secretase 2		 31.3						5		US Patent		10.7270/Q2V69MMC		aid1795118	US10047098	Dai, X; Cumming, JN; Liu, H; Scott, JD	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228068&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89462242	375077011							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525133	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2c1	InChI=1S/C19H20FN7O3S/c1-19(10-31(28,29)27(2)18(21)26-19)13-7-15(23-9-14(13)20)25-17-16-11(4-5-22-17)6-12(30-3)8-24-16/h4-9H,10H2,1-3H3,(H2,21,26)(H,22,23,25)/t19-/m0/s1	OVWPNZBTKNPUGS-IBGZPJMESA-N	276790	N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]pyridin-2-yl}-3-methoxy-1,7-naphthyridin-8-amine::US10071998, Example 5	Beta-secretase 2		 4.50						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276790	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276790&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435138	378158447							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525135	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(cnc23)[N+]#[C-])ccc1F	InChI=1S/C20H18FN7O2S/c1-20(11-31(29,30)28(3)19(22)27-20)15-9-13(4-5-16(15)21)26-18-17-12(6-7-24-18)8-14(23-2)10-25-17/h4-10H,11H2,1,3H3,(H2,22,27)(H,24,26)/t20-/m0/s1	SBOOCSOKIQKLPY-FQEVSTJZSA-N	276791	8-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}amino)-1,7-naphthyridine-3-carbonitrile::US10071998, Example 6	Beta-secretase 2		 0.460						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276791&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214429	378158448							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525137	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2ncnc3cc(cnc23)[N+]#[C-])ccc1F	InChI=1S/C19H17FN8O2S/c1-19(9-31(29,30)28(3)18(21)27-19)13-6-11(4-5-14(13)20)26-17-16-15(24-10-25-17)7-12(22-2)8-23-16/h4-8,10H,9H2,1,3H3,(H2,21,27)(H,24,25,26)/t19-/m0/s1	RRNBDRLPMVARJO-IBGZPJMESA-N	276792	4-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}amino)pyrido[3,2-d]pyrimidine-7-carbonitrile::US10071998, Example 7	Beta-secretase 2		 3.00						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276792	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276792&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214430	378158449							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525139	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(F)cnc23)ccc1F	InChI=1S/C19H18F2N6O2S/c1-19(10-30(28,29)27(2)18(22)26-19)14-8-13(3-4-15(14)21)25-17-16-11(5-6-23-17)7-12(20)9-24-16/h3-9H,10H2,1-2H3,(H2,22,26)(H,23,25)/t19-/m0/s1	ILDBHCXYFTUYOS-IBGZPJMESA-N	276793	3-fluoro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-1,7-naphthyridin-8-amine::US10071998, Example 8	Beta-secretase 2		 0.240						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276793	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276793&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435132	378158450							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525141	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2n1	InChI=1S/C19H20FN7O3S/c1-19(10-31(28,29)27(2)18(21)26-19)12-8-11(4-5-13(12)20)24-17-16-14(6-7-22-17)25-15(30-3)9-23-16/h4-9H,10H2,1-3H3,(H2,21,26)(H,22,24)/t19-/m0/s1	MJFKTBQUUWGCDD-IBGZPJMESA-N	276794	N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-2-methoxypyrido[3,4-b]pyrazin-5-amine::US10071998, Example 9	Beta-secretase 2		 3.50						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276794&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435063	378158451							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525143	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)ncnc2c1	InChI=1S/C18H19FN8O3S/c1-18(8-31(28,29)27(2)17(20)26-18)11-5-14(21-7-12(11)19)25-16-15-13(23-9-24-16)4-10(30-3)6-22-15/h4-7,9H,8H2,1-3H3,(H2,20,26)(H,21,23,24,25)/t18-/m0/s1	ANUKDYGGGASHSK-SFHVURJKSA-N	276795	N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]pyridin-2-yl}-2-methoxypyrido[3,4-b]pyrazin-5-amine::US10071998, Example 10	Beta-secretase 2		 6.90						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276795	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276795&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435118	378158452							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525145	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(Nc2nccc3cc(cnc23)[N+]#[C-])c1F	InChI=1S/C20H17F2N7O2S/c1-20(10-32(30,31)29(3)19(23)28-20)15-13(21)4-5-14(16(15)22)27-18-17-11(6-7-25-18)8-12(24-2)9-26-17/h4-9H,10H2,1,3H3,(H2,23,28)(H,25,27)/t20-/m0/s1	VPVXNJPVCHXXDB-FQEVSTJZSA-N	276796	8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}amino)-1,7-naphthyridine-3-carbonitrile::US10071998, Example 11	Beta-secretase 2		 1.10						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276796&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214431	378158453							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525147	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3nc(cnc23)C(F)F)ccc1F	InChI=1S/C19H18F3N7O2S/c1-19(9-32(30,31)29(2)18(23)28-19)11-7-10(3-4-12(11)20)26-17-15-13(5-6-24-17)27-14(8-25-15)16(21)22/h3-8,16H,9H2,1-2H3,(H2,23,28)(H,24,26)/t19-/m0/s1	WOUMKNJAFGUMDR-IBGZPJMESA-N	276797	2-(difluoromethyl)-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}pyrido[3,4-b]pyrazin-5-amine::US10071998, Example 12	Beta-secretase 2		 1.80						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276797	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276797&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435120	378158454							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525149	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)ncnc2n1	InChI=1S/C18H19FN8O3S/c1-18(8-31(28,29)27(2)17(20)26-18)11-6-10(4-5-12(11)19)24-15-14-16(23-9-22-15)25-13(30-3)7-21-14/h4-7,9H,8H2,1-3H3,(H2,20,26)(H,22,23,24,25)/t18-/m0/s1	ABYZMGTWHCRYBZ-SFHVURJKSA-N	276798	N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-7-methoxypteridin-4-amine::US10071998, Example 13	Beta-secretase 2		 15.4						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276798&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435121	378158455							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525151	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)ncnc2c1	InChI=1S/C19H20FN7O3S/c1-19(9-31(28,29)27(2)18(21)26-19)13-6-11(4-5-14(13)20)25-17-16-15(23-10-24-17)7-12(30-3)8-22-16/h4-8,10H,9H2,1-3H3,(H2,21,26)(H,23,24,25)/t19-/m0/s1	OLNCEEMYACPFFF-IBGZPJMESA-N	276799	N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl]phenyl}-7-methoxypyrido[3,2-d]pyrimidin-4-amine::US10071998, Example 14	Beta-secretase 2		 4.40						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276799&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435119	378158456							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525153	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@@H]2CCc3ncc(Cl)cc23)ccc1F	InChI=1S/C19H21ClFN5O2S/c1-19(10-29(27,28)26(2)18(22)25-19)14-8-12(3-4-15(14)21)24-17-6-5-16-13(17)7-11(20)9-23-16/h3-4,7-9,17,24H,5-6,10H2,1-2H3,(H2,22,25)/t17-,19+/m1/s1	AWMWBVLHSLMMBZ-MJGOQNOKSA-N	276800	(R)-5-(5-(((R)-3-chloro-6,7-dihydro-5H-cyc1openta[b]pyridin-5-yl)amino)-2-fluorophenyl)-3-imino-2,5-dimethyl-1,2,4-thiadiazinane 1,1-dioxide::US10071998, Example 15	Beta-secretase 2		 124						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276800&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435135	378158457							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525155	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@@H]2CCc3ncc(cc23)C(F)(F)F)ccc1F	InChI=1S/C20H21F4N5O2S/c1-19(10-32(30,31)29(2)18(25)28-19)14-8-12(3-4-15(14)21)27-17-6-5-16-13(17)7-11(9-26-16)20(22,23)24/h3-4,7-9,17,27H,5-6,10H2,1-2H3,(H2,25,28)/t17-,19+/m1/s1	YOWWYWVVJYJYSO-MJGOQNOKSA-N	276801	(R)-5-(2-fluoro-5-(((R)-3-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-5-yl)amino)phenyl)-3-imino-2,5-dimethyl-1,2,4-thiadiazinane 1,1-dioxide::US10071998, Example 16	Beta-secretase 2		 242						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276801&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435131	378158458							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525157	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@H]2CCc3cc(Cl)ccc23)ccc1F	InChI=1S/C20H22ClFN4O2S/c1-20(11-29(27,28)26(2)19(23)25-20)16-10-14(5-7-17(16)22)24-18-8-3-12-9-13(21)4-6-15(12)18/h4-7,9-10,18,24H,3,8,11H2,1-2H3,(H2,23,25)/t18-,20-/m0/s1	DLNOZHRWIDUXQZ-ICSRJNTNSA-N	276802	(R)-5-(5-(((S)-5-chloro-2,3-dihydro-1H-inden-1-yl)amino)-2-fluorophenyl)-3-imino-2,5-dimethyl-1,2,4-thiadiazinane 1,1-dioxide::US10071998, Example 17	Beta-secretase 2		 16.6						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276802&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435127	378158459							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525159	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@H]2CCc3cc(cnc23)[N+]#[C-])ccc1F	InChI=1S/C20H21FN6O2S/c1-20(11-30(28,29)27(3)19(22)26-20)15-9-13(5-6-16(15)21)25-17-7-4-12-8-14(23-2)10-24-18(12)17/h5-6,8-10,17,25H,4,7,11H2,1,3H3,(H2,22,26)/t17-,20-/m0/s1	ZIALEYRTTBBAOQ-PXNSSMCTSA-N	276803	(S)-7-((4-fluoro-3-((R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)amino)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile::US10071998, Example 18	Beta-secretase 2		 22.3						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276803&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214432	378158460							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525161	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@@H]2CCc3cc(cnc23)[N+]#[C-])ccc1F	InChI=1S/C20H21FN6O2S/c1-20(11-30(28,29)27(3)19(22)26-20)15-9-13(5-6-16(15)21)25-17-7-4-12-8-14(23-2)10-24-18(12)17/h5-6,8-10,17,25H,4,7,11H2,1,3H3,(H2,22,26)/t17-,20+/m1/s1	ZIALEYRTTBBAOQ-XLIONFOSSA-N	276804	(R)-7-((4-fluoro-3-((R)-3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)amino)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile::US10071998, Example 19	Beta-secretase 2		 42.6						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276804&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214433	378158461							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
525163	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@H]2CCCc3cc(Br)cnc23)ccc1F	InChI=1S/C20H23BrFN5O2S/c1-20(11-30(28,29)27(2)19(23)26-20)15-9-14(6-7-16(15)22)25-17-5-3-4-12-8-13(21)10-24-18(12)17/h6-10,17,25H,3-5,11H2,1-2H3,(H2,23,26)/t17-,20-/m0/s1	JNQRYCQUQDUDHP-PXNSSMCTSA-N	276805	(R)-5-(5-(((S)-3-bromo-5,6,7,8-tetrahydroquinolin-8-yl)amino)-2-fluorophenyl)-3-imino-2,5-dimethyl-1,2,4-thiadiazinane 1,1-dioxide::US10071998, Example 20	Beta-secretase 2		 43.1						5		US Patent		10.7270/Q2C82CBK		aid1795533	US10071998	Wu, W; He, S; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=276805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=276805&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435122	378158462							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555100	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(Cl)cn4)cc23)CS1(=O)=O	InChI=1S/C18H18ClN5O4S/c1-24-17(20)23-18(10-29(24,26)27)6-7-28-15-5-3-12(8-13(15)18)22-16(25)14-4-2-11(19)9-21-14/h2-5,8-9H,6-7,10H2,1H3,(H2,20,23)(H,22,25)/t18-/m0/s1	MZRRDESBEQQOJE-SFHVURJKSA-N	290697	US9580396, Example 1a	Beta-secretase 2		 17.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=290697	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=290697&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287195	381611015							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555102	COc1ccc(nc1)C(=O)Nc1ccc2OCC[C@]3(CS(=O)(=O)N(C)C(=N)N3)c2c1	InChI=1S/C19H21N5O5S/c1-24-18(20)23-19(11-30(24,26)27)7-8-29-16-6-3-12(9-14(16)19)22-17(25)15-5-4-13(28-2)10-21-15/h3-6,9-10H,7-8,11H2,1-2H3,(H2,20,23)(H,22,25)/t19-/m0/s1	VCLABADXPNRDCW-IBGZPJMESA-N	291106	US9580396, Example 1b	Beta-secretase 2		 130						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291106&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287196	381611413							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555104	COCC(=O)Nc1ccc2OCC[C@]3(CS(=O)(=O)N(C)C(=N)N3)c2c1	InChI=1S/C15H20N4O5S/c1-19-14(16)18-15(9-25(19,21)22)5-6-24-12-4-3-10(7-11(12)15)17-13(20)8-23-2/h3-4,7H,5-6,8-9H2,1-2H3,(H2,16,18)(H,17,20)/t15-/m0/s1	VTEPBMKUHQXDEL-HNNXBMFYSA-N	291107	US9580396, Example 1c	Beta-secretase 2		 341						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291107&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287197	381611414							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555106	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)C(F)F)cc23)CS1(=O)=O	InChI=1S/C14H16F2N4O4S/c1-20-13(17)19-14(7-25(20,22)23)4-5-24-10-3-2-8(6-9(10)14)18-12(21)11(15)16/h2-3,6,11H,4-5,7H2,1H3,(H2,17,19)(H,18,21)/t14-/m0/s1	JKTNAVWFNINKLK-AWEZNQCLSA-N	291108	US9580396, Example 1d	Beta-secretase 2		 728						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291108&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287334	381611415							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555108	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(OCF)cn4)cc23)CS1(=O)=O	InChI=1S/C19H20FN5O5S/c1-25-18(21)24-19(10-31(25,27)28)6-7-29-16-5-2-12(8-14(16)19)23-17(26)15-4-3-13(9-22-15)30-11-20/h2-5,8-9H,6-7,10-11H2,1H3,(H2,21,24)(H,23,26)/t19-/m0/s1	JEIYFYBPKPLDRP-IBGZPJMESA-N	291109	US9580396, Example 2a	Beta-secretase 2		 59.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291109&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285673	381611416							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555110	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4coc(C)n4)cc23)CS1(=O)=O	InChI=1S/C17H19N5O5S/c1-10-19-13(8-27-10)15(23)20-11-3-4-14-12(7-11)17(5-6-26-14)9-28(24,25)22(2)16(18)21-17/h3-4,7-8H,5-6,9H2,1-2H3,(H2,18,21)(H,20,23)/t17-/m0/s1	FVGFAGCCFNDSCO-KRWDZBQOSA-N	291110	US9580396, Example 2b	Beta-secretase 2		 20.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291110&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287336	381611417							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555112	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(cn4)[N+]#[C-])cc23)CS1(=O)=O	InChI=1S/C19H18N6O4S/c1-21-13-3-5-15(22-10-13)17(26)23-12-4-6-16-14(9-12)19(7-8-29-16)11-30(27,28)25(2)18(20)24-19/h3-6,9-10H,7-8,11H2,2H3,(H2,20,24)(H,23,26)/t19-/m0/s1	BDMDAFUHRFQUPG-IBGZPJMESA-N	291111	US9580396, Example 2c	Beta-secretase 2		 51.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291111&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137528691	381611418							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555114	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ncc(cn4)C(F)(F)F)cc23)CS1(=O)=O	InChI=1S/C18H17F3N6O4S/c1-27-16(22)26-17(9-32(27,29)30)4-5-31-13-3-2-11(6-12(13)17)25-15(28)14-23-7-10(8-24-14)18(19,20)21/h2-3,6-8H,4-5,9H2,1H3,(H2,22,26)(H,25,28)/t17-/m0/s1	GTQSWZCIQAHYEW-KRWDZBQOSA-N	291112	US9580396, Example 2d	Beta-secretase 2		 780						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291112&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287338	381611419							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555116	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ncc(Cl)cc4F)cc23)CS1(=O)=O	InChI=1S/C18H17ClFN5O4S/c1-25-17(21)24-18(9-30(25,27)28)4-5-29-14-3-2-11(7-12(14)18)23-16(26)15-13(20)6-10(19)8-22-15/h2-3,6-8H,4-5,9H2,1H3,(H2,21,24)(H,23,26)/t18-/m0/s1	WFYUPYOCSTURIG-SFHVURJKSA-N	291113	US9580396, Example 2e	Beta-secretase 2		 9.00						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291113&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287339	381611420							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555118	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4cnc(OCC#C)cn4)cc23)CS1(=O)=O	InChI=1S/C20H20N6O5S/c1-3-7-31-17-11-22-15(10-23-17)18(27)24-13-4-5-16-14(9-13)20(6-8-30-16)12-32(28,29)26(2)19(21)25-20/h1,4-5,9-11H,6-8,12H2,2H3,(H2,21,25)(H,24,27)/t20-/m0/s1	LDODNHLWNGULFY-FQEVSTJZSA-N	291114	US9580396, Example 2f	Beta-secretase 2		 138						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291114&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535368	381611421							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555120	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4cnc(OCC(F)(F)F)cn4)cc23)CS1(=O)=O	InChI=1S/C19H19F3N6O5S/c1-28-17(23)27-18(10-34(28,30)31)4-5-32-14-3-2-11(6-12(14)18)26-16(29)13-7-25-15(8-24-13)33-9-19(20,21)22/h2-3,6-8H,4-5,9-10H2,1H3,(H2,23,27)(H,26,29)/t18-/m0/s1	FNQYVKIMJXZYOM-SFHVURJKSA-N	291115	US9580396, Example 2g	Beta-secretase 2		 699						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291115&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535431	381611422							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555122	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(OCC#C)cn4)cc23)CS1(=O)=O	InChI=1S/C21H21N5O5S/c1-3-9-30-15-5-6-17(23-12-15)19(27)24-14-4-7-18-16(11-14)21(8-10-31-18)13-32(28,29)26(2)20(22)25-21/h1,4-7,11-12H,8-10,13H2,2H3,(H2,22,25)(H,24,27)/t21-/m0/s1	NGNRFTPDKJYMFV-NRFANRHFSA-N	291116	US9580396, Example 2h	Beta-secretase 2		 313						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291116	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291116&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287478	381611423							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555124	COc1cnc(C(=O)Nc2ccc3OCC[C@]4(CS(=O)(=O)N(C)C(=N)N4)c3c2)c(C)c1	InChI=1S/C20H23N5O5S/c1-12-8-14(29-3)10-22-17(12)18(26)23-13-4-5-16-15(9-13)20(6-7-30-16)11-31(27,28)25(2)19(21)24-20/h4-5,8-10H,6-7,11H2,1-3H3,(H2,21,24)(H,23,26)/t20-/m0/s1	ZEWNFILKCZZTHK-FQEVSTJZSA-N	291117	US9580396, Example 2i	Beta-secretase 2		 29.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291117&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287479	381611424							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555126	COc1cnc(C(=O)Nc2ccc3OCC[C@]4(CS(=O)(=O)N(C)C(=N)N4)c3c2)c(C)n1	InChI=1S/C19H22N6O5S/c1-11-16(21-9-15(22-11)29-3)17(26)23-12-4-5-14-13(8-12)19(6-7-30-14)10-31(27,28)25(2)18(20)24-19/h4-5,8-9H,6-7,10H2,1-3H3,(H2,20,24)(H,23,26)/t19-/m0/s1	QYCKKGVAFIRAIH-IBGZPJMESA-N	291118	US9580396, Example 2j	Beta-secretase 2		 160						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291118&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287480	381611425							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555128	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ncc(cc4C)C#N)cc23)CS1(=O)=O	InChI=1S/C20H20N6O4S/c1-12-7-13(9-21)10-23-17(12)18(27)24-14-3-4-16-15(8-14)20(5-6-30-16)11-31(28,29)26(2)19(22)25-20/h3-4,7-8,10H,5-6,11H2,1-2H3,(H2,22,25)(H,24,27)/t20-/m0/s1	OUTYEBXXIJHFSN-FQEVSTJZSA-N	291119	US9580396, Example 2k	Beta-secretase 2		 26.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291119&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287194	381611426							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555130	COc1cnc(cn1)C(=O)Nc1ccc2OCC[C@]3(CS(=O)(=O)N(C)C(=N)N3)c2c1	InChI=1S/C18H20N6O5S/c1-24-17(19)23-18(10-30(24,26)27)5-6-29-14-4-3-11(7-12(14)18)22-16(25)13-8-21-15(28-2)9-20-13/h3-4,7-9H,5-6,10H2,1-2H3,(H2,19,23)(H,22,25)/t18-/m0/s1	SHKHXXYBAIQHBQ-SFHVURJKSA-N	291120	US9580396, Example 2l	Beta-secretase 2		 254						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291120&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535435	381611427							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555132	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4cnc(cn4)C(F)(F)F)cc23)CS1(=O)=O	InChI=1S/C18H17F3N6O4S/c1-27-16(22)26-17(9-32(27,29)30)4-5-31-13-3-2-10(6-11(13)17)25-15(28)12-7-24-14(8-23-12)18(19,20)21/h2-3,6-8H,4-5,9H2,1H3,(H2,22,26)(H,25,28)/t17-/m0/s1	RQBOTTXTWSGISH-KRWDZBQOSA-N	291121	US9580396, Example 2m	Beta-secretase 2		 1150						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291121&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287481	381611428							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555134	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4cc5ccccn5n4)cc23)CS1(=O)=O	InChI=1S/C20H20N6O4S/c1-25-19(21)23-20(12-31(25,28)29)7-9-30-17-6-5-13(10-15(17)20)22-18(27)16-11-14-4-2-3-8-26(14)24-16/h2-6,8,10-11H,7,9,12H2,1H3,(H2,21,23)(H,22,27)/t20-/m0/s1	JZEQFAWVKIWUIH-FQEVSTJZSA-N	291122	US9580396, Example 2n	Beta-secretase 2		 337						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291122	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291122&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287627	381611429							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555136	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(cn4)C(F)(F)F)cc23)CS1(=O)=O	InChI=1S/C19H18F3N5O4S/c1-27-17(23)26-18(10-32(27,29)30)6-7-31-15-5-3-12(8-13(15)18)25-16(28)14-4-2-11(9-24-14)19(20,21)22/h2-5,8-9H,6-7,10H2,1H3,(H2,23,26)(H,25,28)/t18-/m0/s1	ZQXFZYSHKILSIV-SFHVURJKSA-N	291123	US9580396, Example 2o	Beta-secretase 2		 283						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291123&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287628	381611430							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555138	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccn(n4)C(F)F)cc23)CS1(=O)=O	InChI=1S/C17H18F2N6O4S/c1-24-16(20)22-17(9-30(24,27)28)5-7-29-13-3-2-10(8-11(13)17)21-14(26)12-4-6-25(23-12)15(18)19/h2-4,6,8,15H,5,7,9H2,1H3,(H2,20,22)(H,21,26)/t17-/m0/s1	JRSWGOSOPGTDAN-KRWDZBQOSA-N	291124	US9580396, Example 2p	Beta-secretase 2		 3.00						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291124	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291124&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287629	381611431							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555140	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4noc(C)n4)cc23)CS1(=O)=O	InChI=1S/C16H18N6O5S/c1-9-18-13(21-27-9)14(23)19-10-3-4-12-11(7-10)16(5-6-26-12)8-28(24,25)22(2)15(17)20-16/h3-4,7H,5-6,8H2,1-2H3,(H2,17,20)(H,19,23)/t16-/m0/s1	PGVLFIVJUHFIGL-INIZCTEOSA-N	291125	US9580396, Example 2q	Beta-secretase 2		 31.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291125	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291125&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287630	381611432							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555142	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4cn5cc(ccc5n4)C#N)cc23)CS1(=O)=O	InChI=1S/C21H19N7O4S/c1-27-20(23)26-21(12-33(27,30)31)6-7-32-17-4-3-14(8-15(17)21)24-19(29)16-11-28-10-13(9-22)2-5-18(28)25-16/h2-5,8,10-11H,6-7,12H2,1H3,(H2,23,26)(H,24,29)/t21-/m0/s1	JNVBFXOWVFXBDD-NRFANRHFSA-N	291126	US9580396, Example 2r	Beta-secretase 2		 6912						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291126&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535436	381611433							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555144	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4cnsn4)cc23)CS1(=O)=O	InChI=1S/C15H16N6O4S2/c1-21-14(16)19-15(8-27(21,23)24)4-5-25-12-3-2-9(6-10(12)15)18-13(22)11-7-17-26-20-11/h2-3,6-7H,4-5,8H2,1H3,(H2,16,19)(H,18,22)/t15-/m0/s1	LEKHDTHOPXHWTP-HNNXBMFYSA-N	291127	US9580396, Example 2s	Beta-secretase 2		 46.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291127&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287632	381611434							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555146	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(F)cn4)cc23)CS1(=O)=O	InChI=1S/C18H18FN5O4S/c1-24-17(20)23-18(10-29(24,26)27)6-7-28-15-5-3-12(8-13(15)18)22-16(25)14-4-2-11(19)9-21-14/h2-5,8-9H,6-7,10H2,1H3,(H2,20,23)(H,22,25)/t18-/m0/s1	NJQBTQFZSXKHBD-SFHVURJKSA-N	291128	US9580396, Example 2t	Beta-secretase 2		 31.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291128&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287775	381611435							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555148	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(OC(F)F)cn4)cc23)CS1(=O)=O	InChI=1S/C19H19F2N5O5S/c1-26-18(22)25-19(10-32(26,28)29)6-7-30-15-5-2-11(8-13(15)19)24-16(27)14-4-3-12(9-23-14)31-17(20)21/h2-5,8-9,17H,6-7,10H2,1H3,(H2,22,25)(H,24,27)/t19-/m0/s1	GNEDVTBZOIDBEW-IBGZPJMESA-N	291129	US9580396, Example 2u	Beta-secretase 2		 166						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291129&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287776	381611436							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555150	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4ccc(OC(F)(F)F)cn4)cc23)CS1(=O)=O	InChI=1S/C19H18F3N5O5S/c1-27-17(23)26-18(10-33(27,29)30)6-7-31-15-5-2-11(8-13(15)18)25-16(28)14-4-3-12(9-24-14)32-19(20,21)22/h2-5,8-9H,6-7,10H2,1H3,(H2,23,26)(H,25,28)/t18-/m0/s1	UNKAHXGWDAMJGM-SFHVURJKSA-N	291130	US9580396, Example 2v	Beta-secretase 2		 261						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291130&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287777	381611437							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555152	CN1C(=N)N[C@@]2(CCOc3ccc(NC(=O)c4cnc(OCCF)cn4)cc23)CS1(=O)=O	InChI=1S/C19H21FN6O5S/c1-26-18(21)25-19(11-32(26,28)29)4-6-30-15-3-2-12(8-13(15)19)24-17(27)14-9-23-16(10-22-14)31-7-5-20/h2-3,8-10H,4-7,11H2,1H3,(H2,21,25)(H,24,27)/t19-/m0/s1	IXNFHIVAZYRVCG-IBGZPJMESA-N	291131	US9580396, Example 2w	Beta-secretase 2		 572						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291131	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291131&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535375	381611438							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555154	CN1C(=N)N[C@@]2(COCc3ccc(NC(=O)c4ccc(Cl)cn4)cc23)CS1(=O)=O	InChI=1S/C18H18ClN5O4S/c1-24-17(20)23-18(10-29(24,26)27)9-28-8-11-2-4-13(6-14(11)18)22-16(25)15-5-3-12(19)7-21-15/h2-7H,8-10H2,1H3,(H2,20,23)(H,22,25)/t18-/m0/s1	KZHBDZCQOITHGE-SFHVURJKSA-N	291132	US9580396, Example 3a	Beta-secretase 2		 58.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291132&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535442	381611439							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555156	COc1ccc(nc1)C(=O)Nc1ccc2COC[C@]3(CS(=O)(=O)N(C)C(=N)N3)c2c1	InChI=1S/C19H21N5O5S/c1-24-18(20)23-19(11-30(24,26)27)10-29-9-12-3-4-13(7-15(12)19)22-17(25)16-6-5-14(28-2)8-21-16/h3-8H,9-11H2,1-2H3,(H2,20,23)(H,22,25)/t19-/m0/s1	BXVJOJDVSQYEGP-IBGZPJMESA-N	291133	US9580396, Example 3b	Beta-secretase 2		 354						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291133&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535376	381611440							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555158	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(Cl)cn4)cc23)CS1(=O)=O	InChI=1S/C19H20ClN5O3S/c1-25-18(21)24-19(11-29(25,27)28)8-2-3-12-4-6-14(9-15(12)19)23-17(26)16-7-5-13(20)10-22-16/h4-7,9-10H,2-3,8,11H2,1H3,(H2,21,24)(H,23,26)/t19-/m0/s1	WMPFEWSHXOIGJL-IBGZPJMESA-N	291134	US9580396, Example 4a	Beta-secretase 2		 15.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291134&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287779	381611441							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555160	COc1ccc(nc1)C(=O)Nc1ccc2CCC[C@]3(CS(=O)(=O)N(C)C(=N)N3)c2c1	InChI=1S/C20H23N5O4S/c1-25-19(21)24-20(12-30(25,27)28)9-3-4-13-5-6-14(10-16(13)20)23-18(26)17-8-7-15(29-2)11-22-17/h5-8,10-11H,3-4,9,12H2,1-2H3,(H2,21,24)(H,23,26)/t20-/m0/s1	RUUWEIOSBJYYRK-FQEVSTJZSA-N	291135	US9580396, Example 4b	Beta-secretase 2		 67.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291135&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287780	381611442							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555162	COCC(=O)Nc1ccc2CCC[C@]3(CS(=O)(=O)N(C)C(=N)N3)c2c1	InChI=1S/C16H22N4O4S/c1-20-15(17)19-16(10-25(20,22)23)7-3-4-11-5-6-12(8-13(11)16)18-14(21)9-24-2/h5-6,8H,3-4,7,9-10H2,1-2H3,(H2,17,19)(H,18,21)/t16-/m0/s1	PCLQUUAMYZFADT-INIZCTEOSA-N	291136	US9580396, Example 4c	Beta-secretase 2		 260						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291136&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535369	381611443							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555164	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)C(F)F)cc23)CS1(=O)=O	InChI=1S/C15H18F2N4O3S/c1-21-14(18)20-15(8-25(21,23)24)6-2-3-9-4-5-10(7-11(9)15)19-13(22)12(16)17/h4-5,7,12H,2-3,6,8H2,1H3,(H2,18,20)(H,19,22)/t15-/m0/s1	HPRCRXAHETVHJO-HNNXBMFYSA-N	291137	US9580396, Example 4d	Beta-secretase 2		 515						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291137&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287921	381611444							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555166	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4cn5cc(ccc5n4)C#N)cc23)CS1(=O)=O	InChI=1S/C22H21N7O3S/c1-28-21(24)27-22(13-33(28,31)32)8-2-3-15-5-6-16(9-17(15)22)25-20(30)18-12-29-11-14(10-23)4-7-19(29)26-18/h4-7,9,11-12H,2-3,8,13H2,1H3,(H2,24,27)(H,25,30)/t22-/m0/s1	LCBYLSGVNOSMHV-QFIPXVFZSA-N	291138	US9580396, Example 5a	Beta-secretase 2		 1131						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291138&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535378	381611445							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555168	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(F)cn4)cc23)CS1(=O)=O	InChI=1S/C19H20FN5O3S/c1-25-18(21)24-19(11-29(25,27)28)8-2-3-12-4-6-14(9-15(12)19)23-17(26)16-7-5-13(20)10-22-16/h4-7,9-10H,2-3,8,11H2,1H3,(H2,21,24)(H,23,26)/t19-/m0/s1	HCNLZEXPDACZPO-IBGZPJMESA-N	291139	US9580396, Example 5b	Beta-secretase 2		 28.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291139&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535371	381611446							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555170	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(OC(F)F)cn4)cc23)CS1(=O)=O	InChI=1S/C20H21F2N5O4S/c1-27-19(23)26-20(11-32(27,29)30)8-2-3-12-4-5-13(9-15(12)20)25-17(28)16-7-6-14(10-24-16)31-18(21)22/h4-7,9-10,18H,2-3,8,11H2,1H3,(H2,23,26)(H,25,28)/t20-/m0/s1	BPGQNORYVWVOAC-FQEVSTJZSA-N	291140	US9580396, Example 5c	Beta-secretase 2		 126						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291140&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287923	381611447							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555172	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(OC(F)(F)F)cn4)cc23)CS1(=O)=O	InChI=1S/C20H20F3N5O4S/c1-28-18(24)27-19(11-33(28,30)31)8-2-3-12-4-5-13(9-15(12)19)26-17(29)16-7-6-14(10-25-16)32-20(21,22)23/h4-7,9-10H,2-3,8,11H2,1H3,(H2,24,27)(H,26,29)/t19-/m0/s1	WEYUOFWNDKSGIJ-IBGZPJMESA-N	291141	US9580396, Example 5d	Beta-secretase 2		 219						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291141&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287924	381611448							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555174	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4cnc(OCCF)cn4)cc23)CS1(=O)=O	InChI=1S/C20H23FN6O4S/c1-27-19(22)26-20(12-32(27,29)30)6-2-3-13-4-5-14(9-15(13)20)25-18(28)16-10-24-17(11-23-16)31-8-7-21/h4-5,9-11H,2-3,6-8,12H2,1H3,(H2,22,26)(H,25,28)/t20-/m0/s1	MXWKEMWLCMQPMA-FQEVSTJZSA-N	291142	US9580396, Example 5e	Beta-secretase 2		 487						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291142&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535373	381611449							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555176	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4noc(C)n4)cc23)CS1(=O)=O	InChI=1S/C17H20N6O4S/c1-10-19-14(22-27-10)15(24)20-12-6-5-11-4-3-7-17(13(11)8-12)9-28(25,26)23(2)16(18)21-17/h5-6,8H,3-4,7,9H2,1-2H3,(H2,18,21)(H,20,24)/t17-/m0/s1	WXUALMXOFPSQON-KRWDZBQOSA-N	291143	US9580396, Example 5f	Beta-secretase 2		 16.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291143&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287926	381611450							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555178	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(OCF)cn4)cc23)CS1(=O)=O	InChI=1S/C20H22FN5O4S/c1-26-19(22)25-20(11-31(26,28)29)8-2-3-13-4-5-14(9-16(13)20)24-18(27)17-7-6-15(10-23-17)30-12-21/h4-7,9-10H,2-3,8,11-12H2,1H3,(H2,22,25)(H,24,27)/t20-/m0/s1	FSOATLWAAOWFCG-FQEVSTJZSA-N	291144	US9580396, Example 5g	Beta-secretase 2		 33.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291144&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535380	381611451							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555180	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4coc(C)n4)cc23)CS1(=O)=O	InChI=1S/C18H21N5O4S/c1-11-20-15(9-27-11)16(24)21-13-6-5-12-4-3-7-18(14(12)8-13)10-28(25,26)23(2)17(19)22-18/h5-6,8-9H,3-4,7,10H2,1-2H3,(H2,19,22)(H,21,24)/t18-/m0/s1	RQHRGRIECQTSAK-SFHVURJKSA-N	291145	US9580396, Example 5h	Beta-secretase 2		 11.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291145&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285674	381611452							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555182	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)CS1(=O)=O	InChI=1S/C20H20N6O3S/c1-26-19(22)25-20(12-30(26,28)29)8-2-3-14-5-6-15(9-16(14)20)24-18(27)17-7-4-13(10-21)11-23-17/h4-7,9,11H,2-3,8,12H2,1H3,(H2,22,25)(H,24,27)/t20-/m0/s1	SHZJKEXCCIBORH-FQEVSTJZSA-N	291146	US9580396, Example 5i	Beta-secretase 2		 44.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291146&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285983	381611453							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555184	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ncc(cn4)C(F)(F)F)cc23)CS1(=O)=O	InChI=1S/C19H19F3N6O3S/c1-28-17(23)27-18(10-32(28,30)31)6-2-3-11-4-5-13(7-14(11)18)26-16(29)15-24-8-12(9-25-15)19(20,21)22/h4-5,7-9H,2-3,6,10H2,1H3,(H2,23,27)(H,26,29)/t18-/m0/s1	ITULTALJGSVECT-SFHVURJKSA-N	291147	US9580396, Example 5j	Beta-secretase 2		 423						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291147&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535379	381611454							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555186	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ncc(Cl)cc4F)cc23)CS1(=O)=O	InChI=1S/C19H19ClFN5O3S/c1-26-18(22)25-19(10-30(26,28)29)6-2-3-11-4-5-13(8-14(11)19)24-17(27)16-15(21)7-12(20)9-23-16/h4-5,7-9H,2-3,6,10H2,1H3,(H2,22,25)(H,24,27)/t19-/m0/s1	KAQOBXMBTOJNJN-IBGZPJMESA-N	291148	US9580396, Example 5k	Beta-secretase 2		 8.00						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291148&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285676	381611455							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555188	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4cnc(OCC#C)cn4)cc23)CS1(=O)=O	InChI=1S/C21H22N6O4S/c1-3-9-31-18-12-23-17(11-24-18)19(28)25-15-7-6-14-5-4-8-21(16(14)10-15)13-32(29,30)27(2)20(22)26-21/h1,6-7,10-12H,4-5,8-9,13H2,2H3,(H2,22,26)(H,25,28)/t21-/m0/s1	LWRYSCWNOARRIE-NRFANRHFSA-N	291149	US9580396, Example 5l	Beta-secretase 2		 77.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291149&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285677	381611456							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555190	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4cnc(OCC(F)(F)F)cn4)cc23)CS1(=O)=O	InChI=1S/C20H21F3N6O4S/c1-29-18(24)28-19(11-34(29,31)32)6-2-3-12-4-5-13(7-14(12)19)27-17(30)15-8-26-16(9-25-15)33-10-20(21,22)23/h4-5,7-9H,2-3,6,10-11H2,1H3,(H2,24,28)(H,27,30)/t19-/m0/s1	BNJABFVJMDYTTE-IBGZPJMESA-N	291150	US9580396, Example 5m	Beta-secretase 2		 508						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291150&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285678	381611457							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555192	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(OCC#C)cn4)cc23)CS1(=O)=O	InChI=1S/C22H23N5O4S/c1-3-11-31-17-8-9-19(24-13-17)20(28)25-16-7-6-15-5-4-10-22(18(15)12-16)14-32(29,30)27(2)21(23)26-22/h1,6-9,12-13H,4-5,10-11,14H2,2H3,(H2,23,26)(H,25,28)/t22-/m0/s1	AHFKPBRNRAMYAB-QFIPXVFZSA-N	291151	US9580396, Example 5n	Beta-secretase 2		 221						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291151&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285832	381611458							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555194	COc1cnc(C(=O)Nc2ccc3CCC[C@]4(CS(=O)(=O)N(C)C(=N)N4)c3c2)c(C)c1	InChI=1S/C21H25N5O4S/c1-13-9-16(30-3)11-23-18(13)19(27)24-15-7-6-14-5-4-8-21(17(14)10-15)12-31(28,29)26(2)20(22)25-21/h6-7,9-11H,4-5,8,12H2,1-3H3,(H2,22,25)(H,24,27)/t21-/m0/s1	GVJRWXKACKVIRD-NRFANRHFSA-N	291152	US9580396, Example 5o	Beta-secretase 2		 17.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291152&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285833	381611459							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555196	COc1cnc(C(=O)Nc2ccc3CCC[C@]4(CS(=O)(=O)N(C)C(=N)N4)c3c2)c(C)n1	InChI=1S/C20H24N6O4S/c1-12-17(22-10-16(23-12)30-3)18(27)24-14-7-6-13-5-4-8-20(15(13)9-14)11-31(28,29)26(2)19(21)25-20/h6-7,9-10H,4-5,8,11H2,1-3H3,(H2,21,25)(H,24,27)/t20-/m0/s1	MBASXXHLOWSIKM-FQEVSTJZSA-N	291153	US9580396, Example 5p	Beta-secretase 2		 123						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291153&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285834	381611460							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555198	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ncc(cc4C)C#N)cc23)CS1(=O)=O	InChI=1S/C21H22N6O3S/c1-13-8-14(10-22)11-24-18(13)19(28)25-16-6-5-15-4-3-7-21(17(15)9-16)12-31(29,30)27(2)20(23)26-21/h5-6,8-9,11H,3-4,7,12H2,1-2H3,(H2,23,26)(H,25,28)/t21-/m0/s1	ZSCSZRWAVDZCER-NRFANRHFSA-N	291154	US9580396, Example 5q	Beta-secretase 2		 17.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291154&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			75203407	381611461							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555200	COc1cnc(cn1)C(=O)Nc1ccc2CCC[C@]3(CS(=O)(=O)N(C)C(=N)N3)c2c1	InChI=1S/C19H22N6O4S/c1-25-18(20)24-19(11-30(25,27)28)7-3-4-12-5-6-13(8-14(12)19)23-17(26)15-9-22-16(29-2)10-21-15/h5-6,8-10H,3-4,7,11H2,1-2H3,(H2,20,24)(H,23,26)/t19-/m0/s1	OGAQNAYZNJYEPS-IBGZPJMESA-N	291155	US9580396, Example 5r	Beta-secretase 2		 177						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291155&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285835	381611462							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555202	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4cnc(cn4)C(F)(F)F)cc23)CS1(=O)=O	InChI=1S/C19H19F3N6O3S/c1-28-17(23)27-18(10-32(28,30)31)6-2-3-11-4-5-12(7-13(11)18)26-16(29)14-8-25-15(9-24-14)19(20,21)22/h4-5,7-9H,2-3,6,10H2,1H3,(H2,23,27)(H,26,29)/t18-/m0/s1	HZMYXPYMJZDTGZ-SFHVURJKSA-N	291156	US9580396, Example 5s	Beta-secretase 2		 685						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291156&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285836	381611463							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555204	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4cnsn4)cc23)CS1(=O)=O	InChI=1S/C16H18N6O3S2/c1-22-15(17)20-16(9-27(22,24)25)6-2-3-10-4-5-11(7-12(10)16)19-14(23)13-8-18-26-21-13/h4-5,7-8H,2-3,6,9H2,1H3,(H2,17,20)(H,19,23)/t16-/m0/s1	AHEZUYAKQIOMIM-INIZCTEOSA-N	291157	US9580396, Example 5t	Beta-secretase 2		 56.0						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291157&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285837	381611464							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555206	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4cc5ccccn5n4)cc23)CS1(=O)=O	InChI=1S/C21H22N6O3S/c1-26-20(22)24-21(13-31(26,29)30)9-4-5-14-7-8-15(11-17(14)21)23-19(28)18-12-16-6-2-3-10-27(16)25-18/h2-3,6-8,10-12H,4-5,9,13H2,1H3,(H2,22,24)(H,23,28)/t21-/m0/s1	YPUVMLMOHFNJJA-NRFANRHFSA-N	291158	US9580396, Example 5u	Beta-secretase 2		 385						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291158&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76287922	381611465							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555208	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccc(cn4)C(F)(F)F)cc23)CS1(=O)=O	InChI=1S/C20H20F3N5O3S/c1-28-18(24)27-19(11-32(28,30)31)8-2-3-12-4-6-14(9-15(12)19)26-17(29)16-7-5-13(10-25-16)20(21,22)23/h4-7,9-10H,2-3,8,11H2,1H3,(H2,24,27)(H,26,29)/t19-/m0/s1	LPOATAKSSWVVRT-IBGZPJMESA-N	291159	US9580396, Example 5v	Beta-secretase 2		 171						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291159&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285675	381611466							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
555210	CN1C(=N)N[C@@]2(CCCc3ccc(NC(=O)c4ccn(n4)C(F)F)cc23)CS1(=O)=O	InChI=1S/C18H20F2N6O3S/c1-25-17(21)23-18(10-30(25,28)29)7-2-3-11-4-5-12(9-13(11)18)22-15(27)14-6-8-26(24-14)16(19)20/h4-6,8-9,16H,2-3,7,10H2,1H3,(H2,21,23)(H,22,27)/t18-/m0/s1	SZCZFHFDWCVSAZ-SFHVURJKSA-N	291160	US9580396, Example 5w	Beta-secretase 2		 3.00						5		US Patent		10.7270/Q29K4D9S		aid1795850	US9580396	Cumming, JN; Scott, Jr., JD; Stamford, AW; Iserloh, U; Neelamkavil, SF; Shao, PP; Wilson, JE	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291160&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76285982	381611467							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531877	C[C@]1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)/t16-/m0/s1	WQUQHUCOJVZXJC-INIZCTEOSA-N	116227	US10035794, Example 1::US10683287, Example 1::US8637508, 1	Beta-secretase 2			 260					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356238	199996611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531878	CC1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)	WQUQHUCOJVZXJC-UHFFFAOYSA-N	116228	US10035794, Example 2::US10683287, Example 2::US8637508, 2	Beta-secretase 2			 360					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57523959	199996612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531879	NC1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Cl)cn2)n1	InChI=1S/C16H15ClFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)	CDJHOYHFBRGWII-UHFFFAOYSA-N	279659	5-{6-[(5-Chloro-pyridine-2-carbonyl)-amino]-pyridin-2-yl}-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl-ammonium trifluoro acetate::US10035794, Example 3	Beta-secretase 2			 1400					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279659&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57523960	378161234							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531880	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H15BrFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)/p+1	HBAGGGIQIJILPN-UHFFFAOYSA-O	116230	BDBM279660::US10683287, Example 4::US8637508, 4	Beta-secretase 2			 1700					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116230&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808726	199996614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531881	Cc1cc(cnc1C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1)C#N	InChI=1S/C18H17FN6O2/c1-11-5-12(6-20)7-22-16(11)17(26)24-15-4-2-3-13(23-15)18(9-19)10-27-8-14(21)25-18/h2-5,7H,8-10H2,1H3,(H2,21,25)(H,23,24,26)/p+1	DQUIQKUFQPXKNE-UHFFFAOYSA-O	116231	BDBM279661::US8637508, 5	Beta-secretase 2			 1000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116231&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808727	199996615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531882	Cc1cc(Cl)cnc1C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17ClFN5O2/c1-10-5-11(18)6-21-15(10)16(25)23-14-4-2-3-12(22-14)17(8-19)9-26-7-13(20)24-17/h2-6H,7-9H2,1H3,(H2,20,24)(H,22,23,25)/p+1	OEZZKNFURPODDF-UHFFFAOYSA-O	279662	US10035794, Example 6	Beta-secretase 2			 240					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279662&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214975	378161237							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531883	[O-]C(=O)C(F)(F)F.NC(=S)c1ccc(nc1)C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17FN6O2S.C2HF3O2/c18-8-17(9-26-7-13(19)24-17)12-2-1-3-14(22-12)23-16(25)11-5-4-10(6-21-11)15(20)27;3-2(4,5)1(6)7/h1-6H,7-9H2,(H2,19,24)(H2,20,27)(H,22,23,25);(H,6,7)	IBRIMKZFABBPMR-UHFFFAOYSA-N	279663	US10035794, Example 7	Beta-secretase 2			 8700					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279663	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279663&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214976	378161238							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531884	Cc1cc(cnc1C(=O)Nc1cccc(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H19F3N6O2/c1-11-7-12(8-24)9-26-15(11)16(30)28-14-6-4-5-13(27-14)18(2)10-31-19(3,17(25)29-18)20(21,22)23/h4-7,9H,10H2,1-3H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	HONUCNWSWWNZSP-RBUKOAKNSA-N	116233	US10035794, Example 8::US10683287, Example 8::US8637508, 8	Beta-secretase 2			 20.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116233&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356349	199996617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531885	C[C@@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18-/m1/s1	QSCBNUCKFXAIJL-QZTJIDSGSA-N	116234	BDBM279665::US8637508, 9	Beta-secretase 2			 9900					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116234&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355899	199996618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531886	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18+/m0/s1	QSCBNUCKFXAIJL-ZWKOTPCHSA-N	116235	US10035794, Example 10::US10683287, Example 10::US8637508, 10	Beta-secretase 2			 100.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951951	199996619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531887	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	MTNQDQUYJFDVLS-RBUKOAKNSA-N	116236	US10035794, Example 11::US10683287, Example 11::US8637508, 11	Beta-secretase 2			 12.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116236&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356221	199996620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531888	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19-/m1/s1	MTNQDQUYJFDVLS-RTBURBONSA-N	116237	US10035794, Example 12::US10683287, Example 12::US8637508, 12	Beta-secretase 2			 1300					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355933	199996621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531889	Cc1cc(Cl)cnc1C(=O)Nc1cc(ccn1)C1(CF)COCC(N)=N1	InChI=1S/C17H17ClFN5O2/c1-10-4-12(18)6-22-15(10)16(25)23-14-5-11(2-3-21-14)17(8-19)9-26-7-13(20)24-17/h2-6H,7-9H2,1H3,(H2,20,24)(H,21,23,25)	OLVSRIFVQCSRTD-UHFFFAOYSA-N	279669	5-{2-[(5-Chloro-4,6-dideutero-3-trideuteromethyl-pyridine-2-carbonyl)-amino]-pyridin-4-yl}-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl-ammonium acetate::US10035794, Example 13	Beta-secretase 2			 1500					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279669&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			76555410	378161244							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531890	[NH3+]C1=NC(CF)(COC1)c1ccnc(NC(=O)c2ccc(Cl)cn2)c1	InChI=1S/C16H15ClFN5O2/c17-11-1-2-12(21-6-11)15(24)22-14-5-10(3-4-20-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,20,22,24)/p+1	GPJQSUWRIBDPMP-UHFFFAOYSA-O	116238	BDBM279670::US10683287, Example 14::US8637508, 14	Beta-secretase 2			 4800					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116238&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808729	199996622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531891	Cc1cc(cnc1C(=O)Nc1cc(ccn1)C1(CF)COCC([NH3+])=N1)C(N)=S	InChI=1S/C18H19FN6O2S/c1-10-4-11(16(21)28)6-23-15(10)17(26)24-14-5-12(2-3-22-14)18(8-19)9-27-7-13(20)25-18/h2-6H,7-9H2,1H3,(H2,20,25)(H2,21,28)(H,22,24,26)/p+1	OTLWVMHTRDSPSA-UHFFFAOYSA-O	116239	BDBM279671::US8637508, 15	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116239&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808730	199996623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531892	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19+/m0/s1	VAFUDQUXHDFJQT-RBUKOAKNSA-N	116240	US10035794, Example 16::US10683287, Example 16::US8637508, 16	Beta-secretase 2			 55.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116240&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356350	199996624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531893	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19-/m1/s1	VAFUDQUXHDFJQT-RTBURBONSA-N	116241	US10035794, Example 17::US10683287, Example 17::US8637508, 17	Beta-secretase 2			 4200					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356355	199996625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531894	Cl.NC1=NC(CF)(COC1)c1cc(NC(=O)c2ccc(Br)cn2)cnc1Cl	InChI=1S/C16H14BrClFN5O2.ClH/c17-9-1-2-12(21-4-9)15(25)23-10-3-11(14(18)22-5-10)16(7-19)8-26-6-13(20)24-16;/h1-5H,6-8H2,(H2,20,24)(H,23,25);1H	GOPQMKFOQHZZCI-UHFFFAOYSA-N	279674	5-Bromo-pyridine-2-carboxylic acid [5-(5-amino-3-fluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-6-chloro-pyridin-3-yl]-amide hydrochloride::US10035794, Example 18	Beta-secretase 2			 130					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279674	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279674&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			77014371	378161249							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531895	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2N)C#N)n1	InChI=1S/C19H18F3N7O2/c1-17(9-31-18(2,16(25)29-17)19(20,21)22)12-4-3-5-13(27-12)28-15(30)14-11(24)6-10(7-23)8-26-14/h3-6,8H,9,24H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	QLMSSDKIDFGJDT-ZWKOTPCHSA-N	116243	US10035794, Example 19::US10683287, Example 19::US8637508, 19	Beta-secretase 2			 82.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116243&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355685	199996627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531896	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2Cl)C#N)n1	InChI=1S/C19H16ClF3N6O2/c1-17(9-31-18(2,16(25)29-17)19(21,22)23)12-4-3-5-13(27-12)28-15(30)14-11(20)6-10(7-24)8-26-14/h3-6,8H,9H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	DPIDWDAWIQYLLV-ZWKOTPCHSA-N	116244	US10035794, Example 20::US10683287, Example 20::US8637508, 20	Beta-secretase 2			 41.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116244&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356253	199996628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531897	Cc1cc(Cl)cnc1C(=O)Nc1cccc(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C19H19ClF3N5O2/c1-10-7-11(20)8-25-14(10)15(29)27-13-6-4-5-12(26-13)17(2)9-30-18(3,16(24)28-17)19(21,22)23/h4-8H,9H2,1-3H3,(H2,24,28)(H,26,27,29)/t17-,18+/m0/s1	MGXZYVPDNLXFNB-ZWKOTPCHSA-N	279677	US10035794, Example 21	Beta-secretase 2			 8.00					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279677	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279677&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			136214979	378161252							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531898	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(Br)cc2Cl)n1	InChI=1S/C18H16BrClF3N5O2/c1-16(8-30-17(2,15(24)28-16)18(21,22)23)11-4-3-5-12(26-11)27-14(29)13-10(20)6-9(19)7-25-13/h3-7H,8H2,1-2H3,(H2,24,28)(H,26,27,29)/t16-,17+/m0/s1	VANDNQQVYPKEOC-DLBZAZTESA-N	116245	US10035794, Example 22::US10683287, Example 22::US8637508, 22	Beta-secretase 2			 5.00					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116245&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356247	199996629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531899	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(OCC(F)(F)F)nc2N)n1	InChI=1S/C19H19F6N7O3/c1-16(7-35-17(2,15(27)32-16)19(23,24)25)9-4-3-5-10(29-9)30-14(33)12-13(26)31-11(6-28-12)34-8-18(20,21)22/h3-6H,7-8H2,1-2H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t16-,17+/m0/s1	FFRBKRVVRVORIQ-DLBZAZTESA-N	116246	US10035794, Example 23::US8637508, 23	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602533	199996630							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531900	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	LHTZVIDMVHFLLF-ZWKOTPCHSA-N	116247	US10035794, Example 24::US10683287, Example 35::US8637508, 24	Beta-secretase 2			 10.00					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355131	199996631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531901	COc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)c1	InChI=1S/C20H21F4N5O3/c1-10-7-11(31-4)8-26-14(10)16(30)28-13-6-5-12(21)15(27-13)18(2)9-32-19(3,17(25)29-18)20(22,23)24/h5-8H,9H2,1-4H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	PWIJFDYDPIMSCV-RBUKOAKNSA-N	116248	US10035794, Example 25::US10683287, Example 25::US8637508, 25	Beta-secretase 2			 15.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356220	199996632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531902	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OCC(F)(F)F)nc2N)ccc1F	InChI=1S/C19H18F7N7O3/c1-16(6-36-17(2,15(28)33-16)19(24,25)26)12-8(20)3-4-9(30-12)31-14(34)11-13(27)32-10(5-29-11)35-7-18(21,22)23/h3-5H,6-7H2,1-2H3,(H2,27,32)(H2,28,33)(H,30,31,34)/t16-,17+/m0/s1	FKENLPZVPNVYQW-DLBZAZTESA-N	116249	US10035794, Example 26::US8637508, 26	Beta-secretase 2			 6400					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116249&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602362	199996633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531903	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2N)C#N)ccc1F	InChI=1S/C19H17F4N7O2/c1-17(8-32-18(2,16(26)30-17)19(21,22)23)14-10(20)3-4-12(28-14)29-15(31)13-11(25)5-9(6-24)7-27-13/h3-5,7H,8,25H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	MWIIPGZITGHTPU-ZWKOTPCHSA-N	116250	US10035794, Example 27::US10683287, Example 27::US8637508, 27	Beta-secretase 2			 12.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951901	199996634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531904	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	LHTZVIDMVHFLLF-ZWKOTPCHSA-N	116247	US10035794, Example 24::US10683287, Example 35::US8637508, 24	Beta-secretase 2			 1900					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355131	199996631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531905	Cc1cc(OC(F)F)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H19F6N5O3/c1-9-6-10(34-17(22)23)7-28-13(9)15(32)30-12-5-4-11(21)14(29-12)18(2)8-33-19(3,16(27)31-18)20(24,25)26/h4-7,17H,8H2,1-3H3,(H2,27,31)(H,29,30,32)/t18-,19+/m0/s1	IEGJECJTLOSIQV-RBUKOAKNSA-N	116252	US10035794, Example 29::US10683287, Example 30::US8637508, 29	Beta-secretase 2			 24.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116252&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602949	199996636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531906	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)ccc1F	InChI=1S/C19H16ClF6N5O3/c1-17(7-33-18(2,15(27)31-17)19(24,25)26)13-10(21)3-4-11(29-13)30-14(32)12-9(20)5-8(6-28-12)34-16(22)23/h3-6,16H,7H2,1-2H3,(H2,27,31)(H,29,30,32)/t17-,18+/m0/s1	DOJQNRYLSRMQDA-ZWKOTPCHSA-N	116253	US10035794, Example 30::US10683287, Example 36::US8637508, 30	Beta-secretase 2			 24.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951915	199996637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531907	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C18H15Cl2F4N5O2/c1-16(7-31-17(2,15(25)29-16)18(22,23)24)13-10(21)3-4-11(27-13)28-14(30)12-9(20)5-8(19)6-26-12/h3-6H,7H2,1-2H3,(H2,25,29)(H,27,28,30)/t16-,17+/m0/s1	DRKAFGKWERJHKK-DLBZAZTESA-N	116254	US10035794, Example 31::US10683287, Example 31::US8637508, 31	Beta-secretase 2			 1.000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951906	199996638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531908	Cc1cc(OCF)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H20F5N5O3/c1-10-6-11(32-9-21)7-27-14(10)16(31)29-13-5-4-12(22)15(28-13)18(2)8-33-19(3,17(26)30-18)20(23,24)25/h4-7H,8-9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	VZKUTAXMEIXBFQ-RBUKOAKNSA-N	116255	US10035794, Example 32::US10683287, Example 32::US8637508, 32	Beta-secretase 2			 7.00					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116255&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356240	199996639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531909	Cc1cnc(cn1)C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C18H18F4N6O2/c1-9-6-25-11(7-24-9)14(29)27-12-5-4-10(19)13(26-12)16(2)8-30-17(3,15(23)28-16)18(20,21)22/h4-7H,8H2,1-3H3,(H2,23,28)(H,26,27,29)/t16-,17+/m0/s1	QEEWKGAHKUUMAX-DLBZAZTESA-N	116256	US10035794, Example 33::US10683287, Example 33::US8637508, 33	Beta-secretase 2			 330					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356222	199996640							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531910	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C19H15ClF7N5O2/c1-16(7-34-17(2,15(28)32-16)19(25,26)27)13-10(21)3-4-11(30-13)31-14(33)12-9(20)5-8(6-29-12)18(22,23)24/h3-6H,7H2,1-2H3,(H2,28,32)(H,30,31,33)/t16-,17+/m0/s1	PSBBWFNMHDUTRH-DLBZAZTESA-N	116257	US10035794, Example 34::US10683287, Example 34::US8637508, 34	Beta-secretase 2			 30.0					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	BUH	6EQM	88602735	199996641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531911	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ncc(cc2Cl)C#N)ncc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)10-4-13(27-7-12(10)21)29-15(31)14-11(20)3-9(5-25)6-28-14/h3-4,6-7H,8H2,1-2H3,(H2,26,30)(H,27,29,31)/t17-,18+/m0/s1	RPVSVZJNXFHPNA-ZWKOTPCHSA-N	116258	US10035794, Example 35::US8637508, 35	Beta-secretase 2			 120					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116258&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356241	199996642							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531912	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ncc(OC(F)F)cc2Cl)ncc1F	InChI=1S/C19H16ClF6N5O3/c1-17(7-33-18(2,15(27)31-17)19(24,25)26)9-4-12(28-6-11(9)21)30-14(32)13-10(20)3-8(5-29-13)34-16(22)23/h3-6,16H,7H2,1-2H3,(H2,27,31)(H,28,30,32)/t17-,18+/m0/s1	QONFJNGJOVKPCS-ZWKOTPCHSA-N	116259	US10035794, Example 36::US8637508, 36	Beta-secretase 2			 280					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116259&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602761	199996643							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531913	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)COC(CF)(CF)C(N)=N1)C#N	InChI=1S/C20H19F3N6O2/c1-11-3-12(5-24)6-27-16(11)17(30)28-15-4-13(14(23)7-26-15)19(2)10-31-20(8-21,9-22)18(25)29-19/h3-4,6-7H,8-10H2,1-2H3,(H2,25,29)(H,26,28,30)/t19-/m0/s1	ZDOMSYMJUOFARG-IBGZPJMESA-N	116260	US10035794, Example 37::US10683287, Example 37::US8637508, 37	Beta-secretase 2			 430					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116260&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70351283	199996644							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531914	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m0/s1	GIKOSRRRDYUWLE-SFHVURJKSA-N	116261	US10035794, Example 38::US10683287, Example 38::US8637508, 38	Beta-secretase 2			 160					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355171	199996645							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531915	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m1/s1	GIKOSRRRDYUWLE-GOSISDBHSA-N	116262	US10035794, Example 39::US10683287, Example 39::US8637508, 39	Beta-secretase 2			 6500					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356010	199996646							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531916	NC1=N[C@](COC1)(C(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C17H12ClF3N6O2/c18-9-3-8(4-22)5-24-13(9)15(28)26-12-2-1-10(19)14(25-12)17(16(20)21)7-29-6-11(23)27-17/h1-3,5,16H,6-7H2,(H2,23,27)(H,25,26,28)/t17-/m0/s1	LVXIXHYWPFXDKS-KRWDZBQOSA-N	116263	US10035794, Example 40::US10683287, Example 40::US8637508, 40	Beta-secretase 2			 170					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116263&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356242	199996647							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531917	Cc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)n1	InChI=1S/C19H20F4N6O2/c1-9-7-25-13(10(2)26-9)15(30)28-12-6-5-11(20)14(27-12)17(3)8-31-18(4,16(24)29-17)19(21,22)23/h5-7H,8H2,1-4H3,(H2,24,29)(H,27,28,30)/t17-,18+/m0/s1	NHQMQCNPITZLAA-ZWKOTPCHSA-N	116264	US10035794, Example 41::US10683287, Example 41::US8637508, 41	Beta-secretase 2			 130					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951896	199996648							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531918	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OCCCF)nc2N)ccc1F	InChI=1S/C20H22F5N7O3/c1-18(9-35-19(2,17(27)32-18)20(23,24)25)14-10(22)4-5-11(29-14)30-16(33)13-15(26)31-12(8-28-13)34-7-3-6-21/h4-5,8H,3,6-7,9H2,1-2H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t18-,19+/m0/s1	JKHHBPZBBWGXHT-RBUKOAKNSA-N	116265	US10035794, Example 42::US10683287, Example 42::US8637508, 42	Beta-secretase 2			 1000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116265&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356059	199996649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531919	COCCn1ccc2nc(C(=O)Nc3ccc(F)c(n3)[C@]3(C)CO[C@](C)(C(N)=N3)C(F)(F)F)c(N)nc12	InChI=1S/C22H24F4N8O3/c1-20(10-37-21(2,19(28)33-20)22(24,25)26)15-11(23)4-5-13(30-15)31-18(35)14-16(27)32-17-12(29-14)6-7-34(17)8-9-36-3/h4-7H,8-10H2,1-3H3,(H2,27,32)(H2,28,33)(H,30,31,35)/t20-,21+/m0/s1	MMFYRHYCSIOPDG-LEWJYISDSA-N	116266	US10035794, Example 43::US10683287, Example 43::US8637508, 43	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116266&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355173	199996650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531920	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(nc2N)C(F)(F)F)ccc1F	InChI=1S/C18H16F7N7O2/c1-15(6-34-16(2,14(27)32-15)18(23,24)25)11-7(19)3-4-9(30-11)31-13(33)10-12(26)29-8(5-28-10)17(20,21)22/h3-5H,6H2,1-2H3,(H2,26,29)(H2,27,32)(H,30,31,33)/t15-,16+/m0/s1	HUQALVJHHCENTE-JKSUJKDBSA-N	116267	US10035794, Example 44::US10683287, Example 44::US8637508, 44	Beta-secretase 2			 180					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116267&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951897	199996651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531921	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nc3ccn(CC(F)F)c3nc2N)ccc1F	InChI=1S/C21H20F6N8O2/c1-19(8-37-20(2,18(29)34-19)21(25,26)27)14-9(22)3-4-12(31-14)32-17(36)13-15(28)33-16-10(30-13)5-6-35(16)7-11(23)24/h3-6,11H,7-8H2,1-2H3,(H2,28,33)(H2,29,34)(H,31,32,36)/t19-,20+/m0/s1	WBCXJAZBPSKARJ-VQTJNVASSA-N	116268	US10035794, Example 45::US8637508, 45	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116268&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602589	199996652							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531922	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C17H15ClF6N6O2/c1-15(6-32-16(2,13(25)28-15)17(22,23)24)11-8(19)3-4-9(26-11)27-12(31)10-7(18)5-30(29-10)14(20)21/h3-5,14H,6H2,1-2H3,(H2,25,28)(H,26,27,31)/t15-,16+/m0/s1	UYFPRMQOSKPOQR-JKSUJKDBSA-N	116269	US10035794, Example 46::US8637508, 46	Beta-secretase 2			 5.00					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116269&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602590	199996653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531923	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nc3ccn(CC(F)F)c3cc2Cl)ccc1F	InChI=1S/C22H19ClF6N6O2/c1-20(9-37-21(2,19(30)34-20)22(27,28)29)17-11(24)3-4-15(32-17)33-18(36)16-10(23)7-13-12(31-16)5-6-35(13)8-14(25)26/h3-7,14H,8-9H2,1-2H3,(H2,30,34)(H,32,33,36)/t20-,21+/m0/s1	KKRXTJDWKWWIKU-LEWJYISDSA-N	116270	US10035794, Example 47::US8637508, 47	Beta-secretase 2			 5400					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116270&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602591	199996654							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
531924	COCCn1ccc2nc(C(=O)Nc3ccc(F)c(n3)[C@]3(C)CO[C@](C)(C(N)=N3)C(F)(F)F)c(Cl)cc12	InChI=1S/C23H23ClF4N6O3/c1-21(11-37-22(2,20(29)33-21)23(26,27)28)18-13(25)4-5-16(31-18)32-19(35)17-12(24)10-15-14(30-17)6-7-34(15)8-9-36-3/h4-7,10H,8-9,11H2,1-3H3,(H2,29,33)(H,31,32,35)/t21-,22+/m0/s1	LUTGKRKBQRZCOA-FCHUYYIVSA-N	116271	US10035794, Example 48::US8637508, 48	Beta-secretase 2			>10000					4.5	25.00 C	US Patent		10.7270/Q2RB76M3		aid1795586	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116271&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356243	199996655							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658488	C[C@]1(CS(=O)(=O)[C@@](CF)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(cnc23)C#N)ccc1F	InChI=1S/C24H22F2N6O2S/c1-23(13-35(33,34)24(12-25,16-2-3-16)22(28)32-23)18-9-17(4-5-19(18)26)31-21-20-15(6-7-29-21)8-14(10-27)11-30-20/h4-9,11,16H,2-3,12-13H2,1H3,(H2,28,32)(H,29,31)/t23-,24-/m0/s1	FBHQTYOTNRAHFY-ZEQRLZLVSA-N	335424	8-((3-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromethyl)- 3-methyl-1,1-dioxido-3,6- dihydro-2H-1,4-thiazin-3-yl)-4- fluorophenyl)amino)-1,7- naphthyridine-3-carbonitrile::US9732088, Example 1	Beta-secretase 2		 0.600								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335424&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568246	384987583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658490	C[C@]1(CS(=O)(=O)[C@@](CF)(C2CC2)C(N)=N1)c1nc(Nc2nccc3cc(cnc23)C#N)ccc1F	InChI=1S/C23H21F2N7O2S/c1-22(12-35(33,34)23(11-24,15-2-3-15)21(27)32-22)19-16(25)4-5-17(30-19)31-20-18-14(6-7-28-20)8-13(9-26)10-29-18/h4-8,10,15H,2-3,11-12H2,1H3,(H2,27,32)(H,28,30,31)/t22-,23-/m0/s1	KRAJGXSWKHNAOL-GOTSBHOMSA-N	335427	8-((6-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromethyl)- 3-methyl-1,1-dioxido-3,6- dihydro-2H-1,4-thiazin-3-yl)-5- fluoropyridin-2-yl)amino)-1,7- naphthyridine-3-carbonitrile::US9732088, Example 2	Beta-secretase 2		 6.90								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335427&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568250	384987586							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658492	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(Br)cnc23)ncc1F	InChI=1S/C22H22BrFN6O2S/c1-21(11-33(31,32)22(2,13-3-4-13)20(25)30-21)15-8-17(27-10-16(15)24)29-19-18-12(5-6-26-19)7-14(23)9-28-18/h5-10,13H,3-4,11H2,1-2H3,(H2,25,30)(H,26,27,29)/t21-,22-/m0/s1	XVUPUDCWWFXVNH-VXKWHMMOSA-N	335430	(3R,6S)-5-amino-3-(2-((3- bromo-1,7-naphthyridin-8- yl)amino)-5-fluoropyridin-4- yl)-6-cyclopropyl-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 3	Beta-secretase 2		 0.350								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335430&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568244	384987589							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658494	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(cnc23)C#N)ncc1F	InChI=1S/C23H22FN7O2S/c1-22(12-34(32,33)23(2,15-3-4-15)21(26)31-22)16-8-18(28-11-17(16)24)30-20-19-14(5-6-27-20)7-13(9-25)10-29-19/h5-8,10-11,15H,3-4,12H2,1-2H3,(H2,26,31)(H,27,28,30)/t22-,23-/m0/s1	YHELUJBWFRIIRE-GOTSBHOMSA-N	335431	8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl-1,1- dioxido-3,6-dihydro-2H-1,4- thiazin-3-yl)-5-fluoropyridin-2- yl)amino)-1,7-naphthyridine-3- carbonitrile::US9732088, Example 4	Beta-secretase 2		 1.50								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335431	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335431&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568247	384987590							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658496	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1nc(Nc2nccc3cc(cnc23)C#N)ncc1F	InChI=1S/C22H21FN8O2S/c1-21(11-34(32,33)22(2,14-3-4-14)19(25)31-21)17-15(23)10-28-20(29-17)30-18-16-13(5-6-26-18)7-12(8-24)9-27-16/h5-7,9-10,14H,3-4,11H2,1-2H3,(H2,25,31)(H,26,28,29,30)/t21-,22-/m0/s1	NZDXTOQNZIQHRE-VXKWHMMOSA-N	335433	8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl-1,1- dioxido-3,6-dihydro-2H-1,4- thiazin-3-yl)-5-fluoropyrimidin- 2-yl)amino)-1,7-naphthyridine- 3-carbonitrile::US9732088, Example 5	Beta-secretase 2		 7.80								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335433&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568245	384987592							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658498	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C23H25FN6O3S/c1-22(12-34(31,32)23(2,14-4-5-14)21(25)30-22)16-9-18(27-11-17(16)24)29-20-19-13(6-7-26-20)8-15(33-3)10-28-19/h6-11,14H,4-5,12H2,1-3H3,(H2,25,30)(H,26,27,29)/t22-,23-/m0/s1	CVIKZJGUFZXXGR-GOTSBHOMSA-N	335434	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- methoxy-1,7-naphthyridin-8- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 6	Beta-secretase 2		 0.570								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335434	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335434&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			102514699	384987593							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658500	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](CF)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C24H25F2N5O3S/c1-23(13-35(32,33)24(12-25,15-3-4-15)22(27)31-23)18-10-16(5-6-19(18)26)30-21-20-14(7-8-28-21)9-17(34-2)11-29-20/h5-11,15H,3-4,12-13H2,1-2H3,(H2,27,31)(H,28,30)/t23-,24-/m0/s1	FIFMFZCLDQSYGA-ZEQRLZLVSA-N	335437	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- methoxy-1,7-naphthyridin-8- yl)amino)phenyl)-6- (fluoromethyl)-3-methyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 7	Beta-secretase 2		 3.60								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335437	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335437&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568286	384987596							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658502	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](CF)(C4CC4)C(N)=N3)nccc2n1	InChI=1S/C23H24F2N6O3S/c1-22(12-35(32,33)23(11-24,13-3-4-13)21(26)31-22)15-9-14(5-6-16(15)25)29-20-19-17(7-8-27-20)30-18(34-2)10-28-19/h5-10,13H,3-4,11-12H2,1-2H3,(H2,26,31)(H,27,29)/t22-,23-/m0/s1	BNDUULCXMIEQJS-GOTSBHOMSA-N	335438	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((2- methoxypyrido[3,4-b]pyrazin- 5-yl)amino)phenyl)-6- (fluoromethyl)-3-methyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 8	Beta-secretase 2		 4.20								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335438	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335438&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129050390	384987597							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658504	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2n1	InChI=1S/C22H24FN7O3S/c1-21(11-34(31,32)22(2,12-4-5-12)20(24)30-21)13-8-16(26-9-14(13)23)29-19-18-15(6-7-25-19)28-17(33-3)10-27-18/h6-10,12H,4-5,11H2,1-3H3,(H2,24,30)(H,25,26,29)/t21-,22-/m0/s1	FUBUEZYZRDLFCH-VXKWHMMOSA-N	335444	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- methoxypyrido[3,4-b]pyrazin- 5-yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 9	Beta-secretase 2		 1.30								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335444	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335444&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568348	384987603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658506	CC#CCOc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C26H27FN6O3S/c1-4-5-10-36-18-11-16-8-9-29-23(22(16)31-13-18)32-21-12-19(20(27)14-30-21)25(2)15-37(34,35)26(3,17-6-7-17)24(28)33-25/h8-9,11-14,17H,6-7,10,15H2,1-3H3,(H2,28,33)(H,29,30,32)/t25-,26-/m0/s1	OLBKIKACONSTEG-UIOOFZCWSA-N	335447	(3R,6S)-5-amino-3-(2-((3-(but- 2-yn-1-yloxy)-1,7-naphthyridin- 8-yl)amino)-5-fluoropyridin-4- yl)-6-cyclopropyl-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 10	Beta-secretase 2		 0.640								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335447&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568350	384987606							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658508	CC#CCOc1cnc2c(Nc3cnc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](CF)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C26H26F2N6O3S/c1-3-4-9-37-19-10-16-7-8-30-23(21(16)31-13-19)33-18-11-20(22(28)32-12-18)25(2)15-38(35,36)26(14-27,17-5-6-17)24(29)34-25/h7-8,10-13,17H,5-6,9,14-15H2,1-2H3,(H2,29,34)(H,30,33)/t25-,26-/m0/s1	KZFGEZJUHWUIBB-UIOOFZCWSA-N	335448	(3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-naphthyridin- 8-yl)amino)-2-fluoropyridin-3- yl)-6-cyclopropyl-6- (fluoromethyl)-3-methyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 11	Beta-secretase 2		 7.50								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335448	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335448&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568347	384987607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658510	COc1cnc2c(Nc3cnc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](CF)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C23H24F2N6O3S/c1-22(12-35(32,33)23(11-24,14-3-4-14)21(26)31-22)17-8-15(9-29-19(17)25)30-20-18-13(5-6-27-20)7-16(34-2)10-28-18/h5-10,14H,3-4,11-12H2,1-2H3,(H2,26,31)(H,27,30)/t22-,23-/m0/s1	BPIPHIRWHIDPGM-GOTSBHOMSA-N	335453	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- methoxy-1,7-naphthyridin-8- yl)amino)pyridin-3-yl)-6- (fluoromethyl)-3-methyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 12	Beta-secretase 2		 3.30								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335453	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335453&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568342	384987612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658512	CC#CCOc1cnc2c(Nc3cnc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](CF)(C4CC4)C(N)=N3)nccc2n1	InChI=1S/C25H25F2N7O3S/c1-3-4-9-37-19-12-30-20-18(33-19)7-8-29-22(20)32-16-10-17(21(27)31-11-16)24(2)14-38(35,36)25(13-26,15-5-6-15)23(28)34-24/h7-8,10-12,15H,5-6,9,13-14H2,1-2H3,(H2,28,34)(H,29,32)/t24-,25-/m0/s1	OVGRAIBUURUVLO-DQEYMECFSA-N	335454	(3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido[3,4- b]pyrazin-5-yl)amino)-2- fluoropyridin-3-yl)-6- cyclopropyl-6-(fluoromethyl)- 3-methyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 13	Beta-secretase 2		 1.10								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335454	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335454&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568264	384987613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658514	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C24H26FN5O3S/c1-23(13-34(31,32)24(2,15-4-5-15)22(26)30-23)18-11-16(6-7-19(18)25)29-21-20-14(8-9-27-21)10-17(33-3)12-28-20/h6-12,15H,4-5,13H2,1-3H3,(H2,26,30)(H,27,29)/t23-,24-/m0/s1	ZKCMQQBUWGTNHE-ZEQRLZLVSA-N	335455	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- methoxy-1,7-naphthyridin-8- yl)amino)phenyl)-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 14	Beta-secretase 2		 2.80								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335455	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335455&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568263	384987614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658516	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ncnc3cc(Br)cnc23)ccc1F	InChI=1S/C22H22BrFN6O2S/c1-21(10-33(31,32)22(2,12-3-4-12)20(25)30-21)15-8-14(5-6-16(15)24)29-19-18-17(27-11-28-19)7-13(23)9-26-18/h5-9,11-12H,3-4,10H2,1-2H3,(H2,25,30)(H,27,28,29)/t21-,22-/m0/s1	PQVUIOFLWIGLEN-VXKWHMMOSA-N	335456	(3R,6S)-5-amino-3-(5-((7- bromopyrido[3,2-d]pyrimidin- 4-yl)amino)-2-fluorophenyl)-6- cyclopropyl-3,6-dimethyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 15	Beta-secretase 2		 0.730								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335456	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335456&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568265	384987615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658518	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ncnc3cc(cnc23)C#N)ccc1F	InChI=1S/C23H22FN7O2S/c1-22(11-34(32,33)23(2,14-3-4-14)21(26)31-22)16-8-15(5-6-17(16)24)30-20-19-18(28-12-29-20)7-13(9-25)10-27-19/h5-8,10,12,14H,3-4,11H2,1-2H3,(H2,26,31)(H,28,29,30)/t22-,23-/m0/s1	BLPDQFTZIQGBQQ-GOTSBHOMSA-N	335457	4-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl-1,1- dioxido-3,6-dihydro-2H-1,4- thiazin-3-yl)-4- fluorophenyl)amino)pyrido[3,2- d]pyrimidine-7-carbonitrile::US9732088, Example 16	Beta-secretase 2		 1.40								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335457	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335457&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568256	384987616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658520	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(Br)cnc23)ccc1F	InChI=1S/C23H23BrFN5O2S/c1-22(12-33(31,32)23(2,14-3-4-14)21(26)30-22)17-10-16(5-6-18(17)25)29-20-19-13(7-8-27-20)9-15(24)11-28-19/h5-11,14H,3-4,12H2,1-2H3,(H2,26,30)(H,27,29)/t22-,23-/m0/s1	GWQUCPLODYOHAI-GOTSBHOMSA-N	335458	8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl-1,1- dioxido-3,6-dihydro-2H-l,4- thiazin-3-yl)-4- fluorophenyl)amino)-1,7- naphthyridine-3-carbonitrile::US9732088, Example 17	Beta-secretase 2		 0.410								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335458	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335458&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568258	384987617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658522	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(cnc23)C#N)ccc1F	InChI=1S/C24H23FN6O2S/c1-23(13-34(32,33)24(2,16-3-4-16)22(27)31-23)18-10-17(5-6-19(18)25)30-21-20-15(7-8-28-21)9-14(11-26)12-29-20/h5-10,12,16H,3-4,13H2,1-2H3,(H2,27,31)(H,28,30)/t23-,24-/m0/s1	CHBPXGAKUSPCAU-ZEQRLZLVSA-N	335459	8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl-1,1- dioxido-3,6-dihydro-2H-1,4- thiazin-3-yl)-4- fluorophenyl)amino)-1,7- naphthyridine-3-carbonitrile::US9732088, Example 18	Beta-secretase 2		 0.640								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335459	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335459&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568260	384987618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658524	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ncnc2c1	InChI=1S/C22H24FN7O3S/c1-21(10-34(31,32)22(2,12-4-5-12)20(24)30-21)14-7-17(25-9-15(14)23)29-19-18-16(27-11-28-19)6-13(33-3)8-26-18/h6-9,11-12H,4-5,10H2,1-3H3,(H2,24,30)(H,25,27,28,29)/t21-,22-/m0/s1	XCGMUTVWAFFLMU-VXKWHMMOSA-N	335460	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- methoxypyrido[3,2- d]pyrimidin-4- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 19	Beta-secretase 2		 21.0								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335460	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335460&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568351	384987619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658526	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ncnc2c1	InChI=1S/C23H25FN6O3S/c1-22(11-34(31,32)23(2,13-4-5-13)21(25)30-22)16-8-14(6-7-17(16)24)29-20-19-18(27-12-28-20)9-15(33-3)10-26-19/h6-10,12-13H,4-5,11H2,1-3H3,(H2,25,30)(H,27,28,29)/t22-,23-/m0/s1	FFZYFESETLWWHR-GOTSBHOMSA-N	335461	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- methoxypyrido[3,2- d]pyrimidin-4- yl)amino)phenyl)-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 20	Beta-secretase 2		 2.40								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335461&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568278	384987620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658528	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ccnc2c1	InChI=1S/C23H25FN6O3S/c1-22(12-34(31,32)23(2,13-4-5-13)21(25)30-22)15-9-19(27-11-16(15)24)29-17-6-7-26-18-8-14(33-3)10-28-20(17)18/h6-11,13H,4-5,12H2,1-3H3,(H2,25,30)(H,26,27,29)/t22-,23-/m0/s1	GPYWXHYNHQRNQX-GOTSBHOMSA-N	335462	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- methoxy-1,5-naphthyridin-4- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 21	Beta-secretase 2		 1.90								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335462	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335462&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568344	384987621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658530	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ncnc2n1	InChI=1S/C22H24FN7O3S/c1-21(10-34(31,32)22(2,12-4-5-12)20(24)30-21)14-8-13(6-7-15(14)23)28-18-17-19(27-11-26-18)29-16(33-3)9-25-17/h6-9,11-12H,4-5,10H2,1-3H3,(H2,24,30)(H,26,27,28,29)/t21-,22-/m0/s1	YIFGFQXGTFGZHO-VXKWHMMOSA-N	335463	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((7- methoxypteridin-4- yl)amino)phenyl)-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 22	Beta-secretase 2		 11.0								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335463	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335463&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568276	384987622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658532	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ncnc2n1	InChI=1S/C21H23FN8O3S/c1-20(9-34(31,32)21(2,11-4-5-11)19(23)30-20)12-6-14(24-7-13(12)22)28-17-16-18(27-10-26-17)29-15(33-3)8-25-16/h6-8,10-11H,4-5,9H2,1-3H3,(H2,23,30)(H,24,26,27,28,29)/t20-,21-/m0/s1	KBHAXEFYGMUHTK-SFTDATJTSA-N	335464	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- methoxypteridin-4- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 23	Beta-secretase 2		 129								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335464	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335464&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568279	384987623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658534	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2n1	InChI=1S/C23H25FN6O3S/c1-22(12-34(31,32)23(2,13-4-5-13)21(25)30-22)15-10-14(6-7-16(15)24)28-20-19-17(8-9-26-20)29-18(33-3)11-27-19/h6-11,13H,4-5,12H2,1-3H3,(H2,25,30)(H,26,28)/t22-,23-/m0/s1	NTNOYWKSYYHCPO-GOTSBHOMSA-N	335465	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((2- methoxypyrido[3,4-b]pyiazin- 5-yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 24	Beta-secretase 2		 3.50								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335465	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335465&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568343	384987624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658536	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(O)cnc23)ncc1F	InChI=1S/C22H23FN6O3S/c1-21(11-33(31,32)22(2,13-3-4-13)20(24)29-21)15-8-17(26-10-16(15)23)28-19-18-12(5-6-25-19)7-14(30)9-27-18/h5-10,13,30H,3-4,11H2,1-2H3,(H2,24,29)(H,25,26,28)/t21-,22-/m0/s1	KUEIENKSQXRQDS-VXKWHMMOSA-N	335466	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- hydroxy-1,7-naphthyridin-8- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 25	Beta-secretase 2		 0.590								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335466	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335466&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137017597	384987625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658538	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(F)cnc23)ncc1F	InChI=1S/C22H22F2N6O2S/c1-21(11-33(31,32)22(2,13-3-4-13)20(25)30-21)15-8-17(27-10-16(15)24)29-19-18-12(5-6-26-19)7-14(23)9-28-18/h5-10,13H,3-4,11H2,1-2H3,(H2,25,30)(H,26,27,29)/t21-,22-/m0/s1	LCPTYACFEQUNJA-VXKWHMMOSA-N	335467	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- fluoro-1,7-naphthyridin-8- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 26	Beta-secretase 2		 1.000								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335467	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335467&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568288	384987626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658540	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(Cl)cnc23)ncc1F	InChI=1S/C22H22ClFN6O2S/c1-21(11-33(31,32)22(2,13-3-4-13)20(25)30-21)15-8-17(27-10-16(15)24)29-19-18-12(5-6-26-19)7-14(23)9-28-18/h5-10,13H,3-4,11H2,1-2H3,(H2,25,30)(H,26,27,29)/t21-,22-/m0/s1	KYNAHWGPJMEWBU-VXKWHMMOSA-N	335468	(3R,6S)-5-amino-3-(2-((3- chloro-1,7-naphthyridin-8- yl)amino)-5-fluoropyridin-4- yl)-6-cyclopropyl-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 27	Beta-secretase 2		 2.90								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335468	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335468&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568280	384987627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658542	CC#CCOc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2n1	InChI=1S/C25H26FN7O3S/c1-4-5-10-36-20-13-30-21-18(31-20)8-9-28-22(21)32-19-11-16(17(26)12-29-19)24(2)14-37(34,35)25(3,15-6-7-15)23(27)33-24/h8-9,11-13,15H,6-7,10,14H2,1-3H3,(H2,27,33)(H,28,29,32)/t24-,25-/m0/s1	WNNAKXIJQVIXSU-DQEYMECFSA-N	335469	(3R,6S)-5-amino-3-(2-((2-(but- 2-yn-1-yloxy)pyrido[3,4- b]pyrazin-5-yl)amino)-5- fluoropyridin-4-yl)-6- cyclopropyl-3,6-dimethyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 28	Beta-secretase 2		 1.20								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335469	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335469&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568281	384987628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658544	CC#CCOc1cnc2c(Nc3cnc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2n1	InChI=1S/C25H26FN7O3S/c1-4-5-10-36-19-13-29-20-18(32-19)8-9-28-22(20)31-16-11-17(21(26)30-12-16)24(2)14-37(34,35)25(3,15-6-7-15)23(27)33-24/h8-9,11-13,15H,6-7,10,14H2,1-3H3,(H2,27,33)(H,28,31)/t24-,25-/m0/s1	BJPKAAAEFSVBLQ-DQEYMECFSA-N	335470	(3R,6S)-5-amino-3-(5-((2-(but- 2-yn-1-yloxy)pyrido[3,4- b]pyrazin-5-yl)amino)-2- fluoropyridin-3-yl)-6- cyclopropyl-3,6-dimethyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 29	Beta-secretase 2		 24.0								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335470	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335470&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568291	384987629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658546	CC#CCOc1cnc2c(Nc3cnc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C26H27FN6O3S/c1-4-5-10-36-19-11-16-8-9-29-23(21(16)30-14-19)32-18-12-20(22(27)31-13-18)25(2)15-37(34,35)26(3,17-6-7-17)24(28)33-25/h8-9,11-14,17H,6-7,10,15H2,1-3H3,(H2,28,33)(H,29,32)/t25-,26-/m0/s1	LAJVFJLBDJBYEL-UIOOFZCWSA-N	335471	(3R,6S)-5-amino-3-(5-((3-(but- 2-yn-1-yloxy)-1,7-naphthyridin- 8-yl)amino)-2-fluoropyridin-3- yl)-6-cyclopropyl-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 30	Beta-secretase 2		 120								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335471	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335471&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568295	384987630							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658548	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ccnc3cccnc23)ncc1F	InChI=1S/C22H23FN6O2S/c1-21(12-32(30,31)22(2,13-5-6-13)20(24)29-21)14-10-18(27-11-15(14)23)28-17-7-9-25-16-4-3-8-26-19(16)17/h3-4,7-11,13H,5-6,12H2,1-2H3,(H2,24,29)(H,25,27,28)/t21-,22-/m0/s1	NTFSPQNSYVQSDW-VXKWHMMOSA-N	335472	(3R,6S)-3-(2-((1,5- naphthyridin-4-yl)amino)-5- fluoropyridin-4-yl)-5-amino-6- cyclopropyl-3,6-dimethyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 31	Beta-secretase 2		 3.60								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335472&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568269	384987631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658550	COc1cnc2c(Nc3cnc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)nccc2c1	InChI=1S/C23H25FN6O3S/c1-22(12-34(31,32)23(2,14-4-5-14)21(25)30-22)17-9-15(10-28-19(17)24)29-20-18-13(6-7-26-20)8-16(33-3)11-27-18/h6-11,14H,4-5,12H2,1-3H3,(H2,25,30)(H,26,29)/t22-,23-/m0/s1	JPRKRIBITUJGJD-GOTSBHOMSA-N	335473	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- methoxy-1,7-naphthyridin-8- yl)amino)pyridin-3-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 32	Beta-secretase 2		 2.60								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335473	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335473&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568266	384987632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658552	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ccnc3cc(Cl)cnc23)ncc1F	InChI=1S/C22H22ClFN6O2S/c1-21(11-33(31,32)22(2,12-3-4-12)20(25)30-21)14-8-18(27-10-15(14)24)29-16-5-6-26-17-7-13(23)9-28-19(16)17/h5-10,12H,3-4,11H2,1-2H3,(H2,25,30)(H,26,27,29)/t21-,22-/m0/s1	FCXFMBYBPKCVQJ-VXKWHMMOSA-N	335474	(3R,6S)-5-amino-3-(2-((7- chloro-1,5-naphthyridin-4- yl)amino)-5-fluoropyridin-4- yl)-6-cyclopropyl-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 33	Beta-secretase 2		 0.820								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335474&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568270	384987633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658554	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ccnc3cc(F)cnc23)ncc1F	InChI=1S/C22H22F2N6O2S/c1-21(11-33(31,32)22(2,12-3-4-12)20(25)30-21)14-8-18(27-10-15(14)24)29-16-5-6-26-17-7-13(23)9-28-19(16)17/h5-10,12H,3-4,11H2,1-2H3,(H2,25,30)(H,26,27,29)/t21-,22-/m0/s1	HWNAGSUQQMJHQF-VXKWHMMOSA-N	335475	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- fluoro-1,5-naphthyridin-4- yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 34	Beta-secretase 2		 1.70								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335475	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335475&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568257	384987634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658556	COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ccnc2n1	InChI=1S/C22H24FN7O3S/c1-21(11-34(31,32)22(2,12-4-5-12)20(24)30-21)13-8-16(26-9-14(13)23)28-15-6-7-25-19-18(15)27-10-17(29-19)33-3/h6-10,12H,4-5,11H2,1-3H3,(H2,24,30)(H,25,26,28,29)/t21-,22-/m0/s1	OTPAXBCWXPWHGP-VXKWHMMOSA-N	335476	(3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((3- methoxypyrido[2,3-b]pyrazin- 8-yl)amino)pyridin-4-yl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 35	Beta-secretase 2		 2.20								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335476	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335476&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568259	384987635							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658558	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ccnc2c1	InChI=1S/C24H26FN5O3S/c1-23(13-34(31,32)24(2,14-4-5-14)22(26)30-23)17-10-15(6-7-18(17)25)29-19-8-9-27-20-11-16(33-3)12-28-21(19)20/h6-12,14H,4-5,13H2,1-3H3,(H2,26,30)(H,27,29)/t23-,24-/m0/s1	YEEDEQXEFZWMQS-ZEQRLZLVSA-N	335477	(3R,6S)-5-amino-6- cycIopropyl-3-(2-fluoro-5-((7- methoxy-1,5-naphthyridin-4- yl)amino)phenyl)-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 36	Beta-secretase 2		 20.0								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335477	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335477&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568261	384987636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658560	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)[C@@](C)(C4CC4)C(N)=N3)ccnc2n1	InChI=1S/C23H25FN6O3S/c1-22(12-34(31,32)23(2,13-4-5-13)21(25)30-22)15-10-14(6-7-16(15)24)28-17-8-9-26-20-19(17)27-11-18(29-20)33-3/h6-11,13H,4-5,12H2,1-3H3,(H2,25,30)(H,26,28,29)/t22-,23-/m0/s1	TXEKGEDTONZIHF-GOTSBHOMSA-N	335478	(3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((3- methoxypyrido[2,3-b]pyrazin- 8-yl)amino)phenyl)-3,6- dimethyl-3,6-dihydro-2H-1,4- thiazine 1,1-dioxide::US9732088, Example 37	Beta-secretase 2		 53.0								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335478&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568284	384987637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658562	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ncnc3cc(Br)cnc23)ncc1F	InChI=1S/C21H21BrFN7O2S/c1-20(9-33(31,32)21(2,11-3-4-11)19(24)30-20)13-6-16(25-8-14(13)23)29-18-17-15(27-10-28-18)5-12(22)7-26-17/h5-8,10-11H,3-4,9H2,1-2H3,(H2,24,30)(H,25,27,28,29)/t20-,21-/m0/s1	NDZHGDWZVWRPRL-SFTDATJTSA-N	335479	(3R,6S)-5-amino-3-(2-((7- bromopyrido[3,2-d]pyrimidin- 4-yl)amino)-5-fluoropyridin-4- yl)-6-cyclopropyl-3,6-dimethyl- 3,6-dihydro-2H-1,4-thiazine 1,1-dioxide::US9732088, Example 38	Beta-secretase 2		 3.80								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335479&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568292	384987638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
658564	C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ncnc3cc(cnc23)C#N)ncc1F	InChI=1S/C22H21FN8O2S/c1-21(10-34(32,33)22(2,13-3-4-13)20(25)31-21)14-6-17(26-9-15(14)23)30-19-18-16(28-11-29-19)5-12(7-24)8-27-18/h5-6,8-9,11,13H,3-4,10H2,1-2H3,(H2,25,31)(H,26,28,29,30)/t21-,22-/m0/s1	CVMPFRWKSSVYBK-VXKWHMMOSA-N	335480	4-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl-1,1- dioxido-3,6-dihydro-2H-1,4- thiazin-3-yl)-5-fluoropyridin-2- yl)amino)pyrido[3,2- d]pyrimidine-7-carbonitrile::US9732088, Example 39	Beta-secretase 2		 19.0								US Patent		10.7270/Q2XD13S2		aid1796983	US9732088	Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=335480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=335480&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118568297	384987639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665960	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C20H25FN6O4S/c1-19(2)18(22)26-20(3,11-27(4)32(19,29)30)13-8-12(6-7-14(13)21)25-17(28)15-9-24-16(31-5)10-23-15/h6-10H,11H2,1-5H3,(H2,22,26)(H,25,28)/t20-/m0/s1	GKPYEIKDVUIKPL-FQEVSTJZSA-N	337532	US9745324, 1	Beta-secretase 2		 102								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337532	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337532&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191786	384989580							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665961	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccn(n2)C(F)F)ccc1F	InChI=1S/C19H23F3N6O3S/c1-18(2)16(23)25-19(3,10-27(4)32(18,30)31)12-9-11(5-6-13(12)20)24-15(29)14-7-8-28(26-14)17(21)22/h5-9,17H,10H2,1-4H3,(H2,23,25)(H,24,29)/t19-/m0/s1	RRQYUFLADQWKPZ-IBGZPJMESA-N	337533	US9745324, 2	Beta-secretase 2		 6.00								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337533&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191826	384989581							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665962	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H23F2N5O3S/c1-19(2)18(23)26-20(3,11-27(4)31(19,29)30)14-9-13(6-7-15(14)22)25-17(28)16-8-5-12(21)10-24-16/h5-10H,11H2,1-4H3,(H2,23,26)(H,25,28)/t20-/m0/s1	XPELJAZCMWEMAK-FQEVSTJZSA-N	337534	US9745324, 3	Beta-secretase 2		 13.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337534	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337534&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191827	384989582							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665963	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C21H24F3N5O4S/c1-20(2)18(25)28-21(3,11-29(4)34(20,31)32)14-9-12(5-7-15(14)22)27-17(30)16-8-6-13(10-26-16)33-19(23)24/h5-10,19H,11H2,1-4H3,(H2,25,28)(H,27,30)/t21-/m0/s1	XRSLUCBLZBXPOE-NRFANRHFSA-N	337535	US9745324, 4	Beta-secretase 2		 144								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337535	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337535&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191840	384989583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665964	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C21H23F4N5O3S/c1-19(2)18(26)29-20(3,11-30(4)34(19,32)33)14-9-13(6-7-15(14)22)28-17(31)16-8-5-12(10-27-16)21(23,24)25/h5-10H,11H2,1-4H3,(H2,26,29)(H,28,31)/t20-/m0/s1	HZYDPUNFVKBIJD-FQEVSTJZSA-N	337536	US9745324, 5	Beta-secretase 2		 115								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337536	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337536&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191576	384989584							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665965	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C21H26FN5O4S/c1-20(2)19(23)26-21(3,12-27(4)32(20,29)30)15-10-13(6-8-16(15)22)25-18(28)17-9-7-14(31-5)11-24-17/h6-11H,12H2,1-5H3,(H2,23,26)(H,25,28)/t21-/m0/s1	ZZCYFDMGPXKTBK-NRFANRHFSA-N	337537	US9745324, 6	Beta-secretase 2		 44.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337537	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337537&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191597	384989585							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665966	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H23ClFN5O3S/c1-19(2)18(23)26-20(3,11-27(4)31(19,29)30)14-9-13(6-7-15(14)22)25-17(28)16-8-5-12(21)10-24-16/h5-10H,11H2,1-4H3,(H2,23,26)(H,25,28)/t20-/m0/s1	MXCKMFIYOJFRSU-FQEVSTJZSA-N	337538	US9745324, 7	Beta-secretase 2		 8.00								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337538	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337538&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191591	384989586							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665967	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H23FN6O3S/c1-20(2)19(24)27-21(3,12-28(4)32(20,30)31)15-9-14(6-7-16(15)22)26-18(29)17-8-5-13(10-23)11-25-17/h5-9,11H,12H2,1-4H3,(H2,24,27)(H,26,29)/t21-/m0/s1	UGQYKHWIUUFYHK-NRFANRHFSA-N	337539	US9745324, 8	Beta-secretase 2		 32.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337539	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337539&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191798	384989587							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665968	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N2)c(C)c1	InChI=1S/C22H28FN5O4S/c1-13-9-15(32-6)11-25-18(13)19(29)26-14-7-8-17(23)16(10-14)22(4)12-28(5)33(30,31)21(2,3)20(24)27-22/h7-11H,12H2,1-6H3,(H2,24,27)(H,26,29)/t22-/m0/s1	GDBVKGOVAWMTDW-QFIPXVFZSA-N	337540	US9745324, 9	Beta-secretase 2		 32.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337540	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337540&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191799	384989588							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665969	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N2)c(C)n1	InChI=1S/C21H27FN6O4S/c1-12-17(24-10-16(25-12)32-6)18(29)26-13-7-8-15(22)14(9-13)21(4)11-28(5)33(30,31)20(2,3)19(23)27-21/h7-10H,11H2,1-6H3,(H2,23,27)(H,26,29)/t21-/m0/s1	SWYJBOWZXPOWJK-NRFANRHFSA-N	337541	US9745324, 10	Beta-secretase 2		 59.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337541	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337541&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191800	384989589							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665970	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C22H25FN6O3S/c1-13-8-14(10-24)11-26-18(13)19(30)27-15-6-7-17(23)16(9-15)22(4)12-29(5)33(31,32)21(2,3)20(25)28-22/h6-9,11H,12H2,1-5H3,(H2,25,28)(H,27,30)/t22-/m0/s1	ZAIXIEFCQRWQOJ-QFIPXVFZSA-N	337542	US9745324, 11	Beta-secretase 2		 28.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337542	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337542&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191974	384989590							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665971	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C21H24F4N6O4S/c1-19(2)18(26)30-20(3,10-31(4)36(19,33)34)13-7-12(5-6-14(13)22)29-17(32)15-8-28-16(9-27-15)35-11-21(23,24)25/h5-9H,10-11H2,1-4H3,(H2,26,30)(H,29,32)/t20-/m0/s1	WDHSGGPDVBFITH-FQEVSTJZSA-N	337543	US9745324, 12	Beta-secretase 2		 171								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337543	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337543&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191978	384989591							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665972	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cnccn2)ccc1F	InChI=1S/C19H23FN6O3S/c1-18(2)17(21)25-19(3,11-26(4)30(18,28)29)13-9-12(5-6-14(13)20)24-16(27)15-10-22-7-8-23-15/h5-10H,11H2,1-4H3,(H2,21,25)(H,24,27)/t19-/m0/s1	VZPUKBFHSNFBGU-IBGZPJMESA-N	337544	US9745324, 13	Beta-secretase 2		 110								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337544	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337544&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191975	384989592							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665973	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cnc(OCCF)cn2)ccc1F	InChI=1S/C21H26F2N6O4S/c1-20(2)19(24)28-21(3,12-29(4)34(20,31)32)14-9-13(5-6-15(14)23)27-18(30)16-10-26-17(11-25-16)33-8-7-22/h5-6,9-11H,7-8,12H2,1-4H3,(H2,24,28)(H,27,30)/t21-/m0/s1	VTHVQJKPWHSZCH-NRFANRHFSA-N	337545	US9745324, 14	Beta-secretase 2		 217								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337545	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337545&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191554	384989593							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665974	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2noc(C)n2)ccc1F	InChI=1S/C18H23FN6O4S/c1-10-21-14(24-29-10)15(26)22-11-6-7-13(19)12(8-11)18(4)9-25(5)30(27,28)17(2,3)16(20)23-18/h6-8H,9H2,1-5H3,(H2,20,23)(H,22,26)/t18-/m0/s1	NTONXMSGUQQMOA-SFHVURJKSA-N	337546	US9745324, 15	Beta-secretase 2		 27.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337546	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337546&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191556	384989594							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665975	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cnsn2)ccc1F	InChI=1S/C17H21FN6O3S2/c1-16(2)15(19)22-17(3,9-24(4)29(16,26)27)11-7-10(5-6-12(11)18)21-14(25)13-8-20-28-23-13/h5-8H,9H2,1-4H3,(H2,19,22)(H,21,25)/t17-/m0/s1	KDCAYAXRJBAPHC-KRWDZBQOSA-N	337547	US9745324, 16	Beta-secretase 2		 25.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337547	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337547&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191555	384989595							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665976	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cn3ccc(cc3n2)C#N)ccc1F	InChI=1S/C23H24FN7O3S/c1-22(2)21(26)29-23(3,13-30(4)35(22,33)34)16-10-15(5-6-17(16)24)27-20(32)18-12-31-8-7-14(11-25)9-19(31)28-18/h5-10,12H,13H2,1-4H3,(H2,26,29)(H,27,32)/t23-/m0/s1	IOFUDMIDOAIIQQ-QHCPKHFHSA-N	337548	US9745324, 17	Beta-secretase 2		 7489								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337548	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337548&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191589	384989596							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665977	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccn(C)n2)ccc1F	InChI=1S/C19H25FN6O3S/c1-18(2)17(21)23-19(3,11-26(5)30(18,28)29)13-10-12(6-7-14(13)20)22-16(27)15-8-9-25(4)24-15/h6-10H,11H2,1-5H3,(H2,21,23)(H,22,27)/t19-/m0/s1	KJAVVLJGSPBSOY-IBGZPJMESA-N	337549	US9745324, 18	Beta-secretase 2		 42.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337549	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337549&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191594	384989597							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665978	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cc(C)on2)ccc1F	InChI=1S/C19H24FN5O4S/c1-11-8-15(24-29-11)16(26)22-12-6-7-14(20)13(9-12)19(4)10-25(5)30(27,28)18(2,3)17(21)23-19/h6-9H,10H2,1-5H3,(H2,21,23)(H,22,26)/t19-/m0/s1	RQBOHGBVOMATEM-IBGZPJMESA-N	337550	US9745324, 19	Beta-secretase 2		 347								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337550&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191595	384989598							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665979	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc3nc(C)oc3c2)ccc1F	InChI=1S/C23H26FN5O4S/c1-13-26-18-9-6-14(10-19(18)33-13)20(30)27-15-7-8-17(24)16(11-15)23(4)12-29(5)34(31,32)22(2,3)21(25)28-23/h6-11H,12H2,1-5H3,(H2,25,28)(H,27,30)/t23-/m0/s1	FTQFJLGQCZCXLU-QHCPKHFHSA-N	337551	US9745324, 20	Beta-secretase 2		>9542								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337551	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337551&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191601	384989599							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665980	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccccn2)ccc1F	InChI=1S/C20H24FN5O3S/c1-19(2)18(22)25-20(3,12-26(4)30(19,28)29)14-11-13(8-9-15(14)21)24-17(27)16-7-5-6-10-23-16/h5-11H,12H2,1-4H3,(H2,22,25)(H,24,27)/t20-/m0/s1	PVVATPZRYLBWOX-FQEVSTJZSA-N	337552	US9745324, 21	Beta-secretase 2		 43.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337552&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191578	384989600							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665981	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cc(C)no2)ccc1F	InChI=1S/C19H24FN5O4S/c1-11-8-15(29-24-11)16(26)22-12-6-7-14(20)13(9-12)19(4)10-25(5)30(27,28)18(2,3)17(21)23-19/h6-9H,10H2,1-5H3,(H2,21,23)(H,22,26)/t19-/m0/s1	CCRXEAANBZZELD-IBGZPJMESA-N	337553	US9745324, 22	Beta-secretase 2		 1016								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337553&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191600	384989601							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665982	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F	InChI=1S/C20H22ClF2N5O3S/c1-19(2)18(24)27-20(3,10-28(4)32(19,30)31)13-8-12(5-6-14(13)22)26-17(29)16-15(23)7-11(21)9-25-16/h5-9H,10H2,1-4H3,(H2,24,27)(H,26,29)/t20-/m0/s1	ZCQWCFJFFRDJEI-FQEVSTJZSA-N	337554	US9745324, 23	Beta-secretase 2		 6.40								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337554&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191593	384989602							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665983	COCCC(=O)Nc1ccc(F)c(c1)[C@]1(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H27FN4O4S/c1-17(2)16(20)22-18(3,11-23(4)28(17,25)26)13-10-12(6-7-14(13)19)21-15(24)8-9-27-5/h6-7,10H,8-9,11H2,1-5H3,(H2,20,22)(H,21,24)/t18-/m0/s1	CZADHVWRUJKDKE-SFHVURJKSA-N	337555	US9745324, 24	Beta-secretase 2		 4087								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337555&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191580	384989603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665984	COCC(=O)Nc1ccc(F)c(c1)[C@]1(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C17H25FN4O4S/c1-16(2)15(19)21-17(3,10-22(4)27(16,24)25)12-8-11(6-7-13(12)18)20-14(23)9-26-5/h6-8H,9-10H2,1-5H3,(H2,19,21)(H,20,23)/t17-/m0/s1	CWJNLNWZGJJLAH-KRWDZBQOSA-N	337556	US9745324, 25	Beta-secretase 2		 122								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337556&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191575	384989604							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665985	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cn(C)nc2C(F)(F)F)ccc1F	InChI=1S/C20H24F4N6O3S/c1-18(2)17(25)27-19(3,10-30(5)34(18,32)33)13-8-11(6-7-14(13)21)26-16(31)12-9-29(4)28-15(12)20(22,23)24/h6-9H,10H2,1-5H3,(H2,25,27)(H,26,31)/t19-/m0/s1	JGCCIOHXQCQXDV-IBGZPJMESA-N	337557	US9745324, 26	Beta-secretase 2		 6509								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337557&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191583	384989605							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665986	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cn3ccsc3n2)ccc1F	InChI=1S/C20H23FN6O3S2/c1-19(2)17(22)25-20(3,11-26(4)32(19,29)30)13-9-12(5-6-14(13)21)23-16(28)15-10-27-7-8-31-18(27)24-15/h5-10H,11H2,1-4H3,(H2,22,25)(H,23,28)/t20-/m0/s1	CPSLLDGDVQZDTC-FQEVSTJZSA-N	337558	US9745324, 27	Beta-secretase 2		 46.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337558	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337558&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191596	384989606							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665987	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)C(F)F)ccc1F	InChI=1S/C16H21F3N4O3S/c1-15(2)14(20)22-16(3,8-23(4)27(15,25)26)10-7-9(5-6-11(10)17)21-13(24)12(18)19/h5-7,12H,8H2,1-4H3,(H2,20,22)(H,21,24)/t16-/m0/s1	VZIXEBJOHCOXIN-INIZCTEOSA-N	337559	US9745324, 28	Beta-secretase 2		 354								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337559	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337559&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191590	384989607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665988	CO[C@H](C)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H27FN4O4S/c1-11(27-6)15(24)21-12-7-8-14(19)13(9-12)18(4)10-23(5)28(25,26)17(2,3)16(20)22-18/h7-9,11H,10H2,1-6H3,(H2,20,22)(H,21,24)/t11-,18+/m1/s1	PBQRDVLVFYCPCL-ZMZPIMSZSA-N	337560	US9745324, 29	Beta-secretase 2		 798								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337560	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337560&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191587	384989608							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665989	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)CC2CC2)ccc1F	InChI=1S/C19H27FN4O3S/c1-18(2)17(21)23-19(3,11-24(4)28(18,26)27)14-10-13(7-8-15(14)20)22-16(25)9-12-5-6-12/h7-8,10,12H,5-6,9,11H2,1-4H3,(H2,21,23)(H,22,25)/t19-/m0/s1	WBHPJNUIYLHJGA-IBGZPJMESA-N	337561	US9745324, 30	Beta-secretase 2		 2190								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337561	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337561&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191579	384989609							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665990	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ncc(cn2)C(F)(F)F)ccc1F	InChI=1S/C20H22F4N6O3S/c1-18(2)17(25)29-19(3,10-30(4)34(18,32)33)13-7-12(5-6-14(13)21)28-16(31)15-26-8-11(9-27-15)20(22,23)24/h5-9H,10H2,1-4H3,(H2,25,29)(H,28,31)/t19-/m0/s1	HVEBOLRHEPZBCQ-IBGZPJMESA-N	337562	US9745324, 31	Beta-secretase 2		 202								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337562	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337562&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191592	384989610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665991	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2nc(C)oc2C)ccc1F	InChI=1S/C20H26FN5O4S/c1-11-16(23-12(2)30-11)17(27)24-13-7-8-15(21)14(9-13)20(5)10-26(6)31(28,29)19(3,4)18(22)25-20/h7-9H,10H2,1-6H3,(H2,22,25)(H,24,27)/t20-/m0/s1	LSHFCSFBNFDSKV-FQEVSTJZSA-N	337563	US9745324, 32	Beta-secretase 2		 54.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337563	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337563&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191793	384989611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665992	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)C2CC2)ccc1F	InChI=1S/C18H25FN4O3S/c1-17(2)16(20)22-18(3,10-23(4)27(17,25)26)13-9-12(7-8-14(13)19)21-15(24)11-5-6-11/h7-9,11H,5-6,10H2,1-4H3,(H2,20,22)(H,21,24)/t18-/m0/s1	RMULSANELBAHJW-SFHVURJKSA-N	337564	US9745324, 33	Beta-secretase 2		 1031								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337564&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191789	384989612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665993	CO[C@@H](C)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CN(C)S(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C18H27FN4O4S/c1-11(27-6)15(24)21-12-7-8-14(19)13(9-12)18(4)10-23(5)28(25,26)17(2,3)16(20)22-18/h7-9,11H,10H2,1-6H3,(H2,20,22)(H,21,24)/t11-,18-/m0/s1	PBQRDVLVFYCPCL-VOJFVSQTSA-N	337565	US9745324, 34	Beta-secretase 2		 1120								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337565	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337565&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191791	384989613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665994	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(C)=O)ccc1F	InChI=1S/C16H23FN4O3S/c1-10(22)19-11-6-7-13(17)12(8-11)16(4)9-21(5)25(23,24)15(2,3)14(18)20-16/h6-8H,9H2,1-5H3,(H2,18,20)(H,19,22)/t16-/m0/s1	KJLPAFZYFCPHIK-INIZCTEOSA-N	337566	US9745324, 35	Beta-secretase 2		 917								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337566	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337566&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191792	384989614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665995	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(OCC#C)cn2)ccc1F	InChI=1S/C23H26FN5O4S/c1-6-11-33-16-8-10-19(26-13-16)20(30)27-15-7-9-18(24)17(12-15)23(4)14-29(5)34(31,32)22(2,3)21(25)28-23/h1,7-10,12-13H,11,14H2,2-5H3,(H2,25,28)(H,27,30)/t23-/m0/s1	SNGQXTJFFFLIHV-QHCPKHFHSA-N	337567	US9745324, 36	Beta-secretase 2		 195								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337567	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337567&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191788	384989615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665996	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)(F)F)ccc1F	InChI=1S/C20H22F4N6O3S/c1-18(2)17(25)29-19(3,10-30(4)34(18,32)33)12-7-11(5-6-13(12)21)28-16(31)14-8-27-15(9-26-14)20(22,23)24/h5-9H,10H2,1-4H3,(H2,25,29)(H,28,31)/t19-/m0/s1	BPLBVDMFOILFGQ-IBGZPJMESA-N	337568	US9745324, 37	Beta-secretase 2		 361								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337568	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337568&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191790	384989616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665997	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C21H25F2N5O4S/c1-20(2)19(24)27-21(3,11-28(4)33(20,30)31)15-9-13(5-7-16(15)23)26-18(29)17-8-6-14(10-25-17)32-12-22/h5-10H,11-12H2,1-4H3,(H2,24,27)(H,26,29)/t21-/m0/s1	FOUDLLGOFMGXMY-NRFANRHFSA-N	337569	US9745324, 38	Beta-secretase 2		 46.0								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337569&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118191850	384989617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
665998	CN1C[C@](C)(NC(=N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H25FN6O4S/c1-6-9-33-18-12-25-17(11-26-18)19(30)27-14-7-8-16(23)15(10-14)22(4)13-29(5)34(31,32)21(2,3)20(24)28-22/h1,7-8,10-12H,9,13H2,2-5H3,(H2,24,28)(H,27,30)/t22-/m0/s1	IJKMXPBVUFGDLK-QFIPXVFZSA-N	337570	US9745324, 39	Beta-secretase 2		 34.3								US Patent		10.7270/Q2MS3VW8		aid1797078	US9745324	Dai, X; Cumming, JN; Scott, JD; Liu, H; Palani, A	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=337570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=337570&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91810755	384989618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668114	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H15F2N7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1	ALDQBQZJKOIWIW-SFHVURJKSA-N	338836	US9751886, Compound 1	Beta-secretase 2			 3.31							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338836	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338836&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581403	384990810							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668115	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H15FN8O/c1-19(10-28-16(9-24-27-28)17(22)26-19)13-6-12(3-4-14(13)20)25-18(29)15-5-2-11(7-21)8-23-15/h2-6,8-9H,10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1	XIOGEDRAOXMYRT-IBGZPJMESA-N	338837	US9751886, Compound 2	Beta-secretase 2			 5.37							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338837&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86294744	384990811							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668116	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)Cn2nncc2C(N)=N1	InChI=1S/C18H17FN8O2/c1-18(9-27-14(7-23-26-27)16(20)25-18)11-5-10(3-4-12(11)19)24-17(28)13-6-22-15(29-2)8-21-13/h3-8H,9H2,1-2H3,(H2,20,25)(H,24,28)/t18-/m0/s1	KSZUTAXSHMVGBE-SFHVURJKSA-N	338838	US9751886, Compound 3	Beta-secretase 2			 15.5							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338838	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338838&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581547	384990812							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668117	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H15ClFN7O/c1-18(9-27-15(8-23-26-27)16(21)25-18)12-6-11(3-4-13(12)20)24-17(28)14-5-2-10(19)7-22-14/h2-8H,9H2,1H3,(H2,21,25)(H,24,28)/t18-/m0/s1	FIUOQWQRVSRKHL-SFHVURJKSA-N	338839	US9751886, Compound 4	Beta-secretase 2			 2.75							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338839	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338839&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581548	384990813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668118	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C17H14ClF3N8O/c1-17(7-29-12(5-23-27-29)14(22)25-17)9-4-8(2-3-11(9)19)24-15(30)13-10(18)6-28(26-13)16(20)21/h2-6,16H,7H2,1H3,(H2,22,25)(H,24,30)/t17-/m0/s1	DWQBWXKENFEBOL-KRWDZBQOSA-N	338840	N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide ::US9751886, Compound 5	Beta-secretase 2			 1.86							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338840	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338840&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581549	384990814							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668119	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C19H16F4N8O2/c1-18(8-31-14(6-27-30-31)16(24)29-18)11-4-10(2-3-12(11)20)28-17(32)13-5-26-15(7-25-13)33-9-19(21,22)23/h2-7H,8-9H2,1H3,(H2,24,29)(H,28,32)/t18-/m0/s1	NZTYMOUXRNVYGQ-SFHVURJKSA-N	338841	US9751886, Compound 6	Beta-secretase 2			 60.3							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338841	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338841&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581550	384990815							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668120	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C19H17F2N7O2/c1-19(9-28-16(8-24-27-28)17(22)26-19)13-6-11(2-4-14(13)21)25-18(29)15-5-3-12(7-23-15)30-10-20/h2-8H,9-10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1	IFZVTLKVMBOTCD-IBGZPJMESA-N	338842	US9751886, Compound 7	Beta-secretase 2			 16.6							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338842	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338842&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			138753048	384990816							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668121	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)cc(F)c1F	InChI=1S/C18H14F3N7O/c1-18(8-28-14(7-24-27-28)16(22)26-18)11-4-10(5-12(20)15(11)21)25-17(29)13-3-2-9(19)6-23-13/h2-7H,8H2,1H3,(H2,22,26)(H,25,29)/t18-/m0/s1	DEALMQADSASPQK-SFHVURJKSA-N	338843	N-{3-[(6R)-4-Amino-6-methyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4,5-difluorophenyl}-5-fluoropyridine-2-carboxamide ::US9751886, Compound 8	Beta-secretase 2			 3.02							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338843	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338843&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581552	384990817							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668122	NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1	KTMJHDICOAOUQM-SFHVURJKSA-N	338844	US9751886, Compound 10::US9751886, Compound 9	Beta-secretase 2			 8.32							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338844&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581691	384990818							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668123	NC1=N[C@@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m0/s1	KTMJHDICOAOUQM-SFHVURJKSA-N	338844	US9751886, Compound 10::US9751886, Compound 9	Beta-secretase 2			 3.24							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338844&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581691	384990818							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
668124	NC1=N[C@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H14F3N7O/c19-8-18(9-28-15(7-24-27-28)16(22)26-18)12-5-11(2-3-13(12)21)25-17(29)14-4-1-10(20)6-23-14/h1-7H,8-9H2,(H2,22,26)(H,25,29)/t18-/m1/s1	KTMJHDICOAOUQM-GOSISDBHSA-N	338846	(rac)-N-{3-[4-amino-6-(fluoromethyl)-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide (compound 9), N-{3-[(6R)-4-amino-6-(fluoromethyl)-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide (compound 10), N-{3-[(6S)-4-amino-6-(fluoromethyl)-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide ::US9751886, Compound 11	Beta-secretase 2			 501							US Patent		10.7270/Q2Z321RC		aid1797109	US9751886	Oehlrich, D; Gijsen, HJ	Janssen Pharmaceutica NV	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338846	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338846&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86581690	384990819							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50755719	CCc1cn2CC(C)(C)S(=O)(=O)N(C)c3cc(cc1c23)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)[C@@H]1NCCN(Cc2ccccc2)C1=O	InChI=1S/C36H43N5O5S/c1-5-26-22-41-23-36(2,3)47(45,46)39(4)30-20-27(19-28(26)32(30)41)34(43)38-29(18-24-12-8-6-9-13-24)33(42)31-35(44)40(17-16-37-31)21-25-14-10-7-11-15-25/h6-15,19-20,22,29,31,33,37,42H,5,16-18,21,23H2,1-4H3,(H,38,43)/t29-,31-,33-/m0/s1	WBWSVNAKBNLSOJ-WXWREJFYSA-N	50240557	CHEMBL4065655	Beta-secretase 2		 7140								ChEMBL	10.1016/j.bmcl.2017.04.011	10.7270/Q2R213JX	28427814			Ghosh, AK; Brindisi, M; Yen, YC; Cárdenas, EL; Ella-Menye, JR; Kumaragurubaran, N; Huang, X; Tang, J; Mesecar, AD	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240557&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	8W4	5V0N	14763364	85390388		CHEMBL4065655					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50755727	C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)[C@@H]1NCCN(Cc2ccccc2)C1=O)N(C)S(C)(=O)=O)c1ccccc1	InChI=1S/C38H43N5O6S/c1-26(29-17-11-6-12-18-29)40-36(45)30-22-31(24-32(23-30)42(2)50(3,48)49)37(46)41-33(21-27-13-7-4-8-14-27)35(44)34-38(47)43(20-19-39-34)25-28-15-9-5-10-16-28/h4-18,22-24,26,33-35,39,44H,19-21,25H2,1-3H3,(H,40,45)(H,41,46)/t26-,33+,34+,35+/m1/s1	XFQJUBHCQDVLTG-AVSSONEDSA-N	50240554	CHEMBL4081377	Beta-secretase 2		 134								ChEMBL	10.1016/j.bmcl.2017.04.011	10.7270/Q2R213JX	28427814			Ghosh, AK; Brindisi, M; Yen, YC; Cárdenas, EL; Ella-Menye, JR; Kumaragurubaran, N; Huang, X; Tang, J; Mesecar, AD	Purdue University	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240554&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			493048	85388739		CHEMBL4081377					1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700269	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)C11CC1	InChI=1S/C20H22FN5O4S/c1-19(20(8-9-20)31(28,29)26(2)18(22)25-19)14-10-12(4-6-15(14)21)24-17(27)16-7-5-13(30-3)11-23-16/h4-7,10-11H,8-9H2,1-3H3,(H2,22,25)(H,24,27)/t19-/m1/s1	GLCYCFWBJUZJNZ-LJQANCHMSA-N	352244	US9802928, 1a	Beta-secretase 2		 17.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352244&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189985	386046649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700271	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cn(C)nc3C(F)(F)F)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H20F4N6O3S/c1-17(18(6-7-18)33(31,32)29(3)16(24)26-17)12-8-10(4-5-13(12)20)25-15(30)11-9-28(2)27-14(11)19(21,22)23/h4-5,8-9H,6-7H2,1-3H3,(H2,24,26)(H,25,30)/t17-/m1/s1	COFFNOZXYDOWIH-QGZVFWFLSA-N	352245	US9802928, 1b	Beta-secretase 2		 3247								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352245&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189984	386046650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700273	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(OCC#C)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C22H22FN5O4S/c1-4-11-32-15-6-8-18(25-13-15)19(29)26-14-5-7-17(23)16(12-14)21(2)22(9-10-22)33(30,31)28(3)20(24)27-21/h1,5-8,12-13H,9-11H2,2-3H3,(H2,24,27)(H,26,29)/t21-/m1/s1	AJFHWHDSSGXVPF-OAQYLSRUSA-N	352246	US9802928, 1c	Beta-secretase 2		 95.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189987	386046651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700275	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cnsn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C16H17FN6O3S2/c1-15(16(5-6-16)28(25,26)23(2)14(18)21-15)10-7-9(3-4-11(10)17)20-13(24)12-8-19-27-22-12/h3-4,7-8H,5-6H2,1-2H3,(H2,18,21)(H,20,24)/t15-/m1/s1	WOHKSIPTWIJLRL-OAHLLOKOSA-N	352247	US9802928, 1d	Beta-secretase 2		 15.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189989	386046652							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700277	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)NC(=N)N(C)S(=O)(=O)C11CC1	InChI=1S/C19H21FN6O4S/c1-18(19(6-7-19)31(28,29)26(2)17(21)25-18)12-8-11(4-5-13(12)20)24-16(27)14-9-23-15(30-3)10-22-14/h4-5,8-10H,6-7H2,1-3H3,(H2,21,25)(H,24,27)/t18-/m1/s1	IUKBYXPCHQMWHE-GOSISDBHSA-N	352248	US9802928, 1e	Beta-secretase 2		 56.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189986	386046653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700279	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(cn3)C(F)(F)F)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C20H19F4N5O3S/c1-18(19(7-8-19)33(31,32)29(2)17(25)28-18)13-9-12(4-5-14(13)21)27-16(30)15-6-3-11(10-26-15)20(22,23)24/h3-6,9-10H,7-8H2,1-2H3,(H2,25,28)(H,27,30)/t18-/m1/s1	KRALQEJSZCSMNQ-GOSISDBHSA-N	352249	US9802928, 1f	Beta-secretase 2		 55.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352249&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189988	386046654							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700281	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(cn3)C#N)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C20H19FN6O3S/c1-19(20(7-8-20)31(29,30)27(2)18(23)26-19)14-9-13(4-5-15(14)21)25-17(28)16-6-3-12(10-22)11-24-16/h3-6,9,11H,7-8H2,1-2H3,(H2,23,26)(H,25,28)/t19-/m1/s1	DEBDBRRAVDUWFZ-LJQANCHMSA-N	352251	US9802928, 1g	Beta-secretase 2		 17.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352251&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118190070	386046656							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700283	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3noc(C)n3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C17H19FN6O4S/c1-9-20-13(23-28-9)14(25)21-10-4-5-12(18)11(8-10)16(2)17(6-7-17)29(26,27)24(3)15(19)22-16/h4-5,8H,6-7H2,1-3H3,(H2,19,22)(H,21,25)/t16-/m1/s1	UCCYOUBYPQTNGK-MRXNPFEDSA-N	352252	US9802928, 1h	Beta-secretase 2		 8.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352252&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189967	386046657							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700285	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ncc(cn3)C(F)(F)F)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18F4N6O3S/c1-17(18(5-6-18)33(31,32)29(2)16(24)28-17)12-7-11(3-4-13(12)20)27-15(30)14-25-8-10(9-26-14)19(21,22)23/h3-4,7-9H,5-6H2,1-2H3,(H2,24,28)(H,27,30)/t17-/m1/s1	QMYDGOMATQIVFT-QGZVFWFLSA-N	352253	US9802928, 1i	Beta-secretase 2		 106								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189963	386046658							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700287	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@@]2(C)NC(=N)N(C)S(=O)(=O)C22CC2)c(C)c1	InChI=1S/C21H24FN5O4S/c1-12-9-14(31-4)11-24-17(12)18(28)25-13-5-6-16(22)15(10-13)20(2)21(7-8-21)32(29,30)27(3)19(23)26-20/h5-6,9-11H,7-8H2,1-4H3,(H2,23,26)(H,25,28)/t20-/m1/s1	UCWBLHDJHCBRHF-HXUWFJFHSA-N	352254	US9802928, 1j	Beta-secretase 2		 10.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189968	386046659							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700289	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ncc(cc3C)C#N)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C21H21FN6O3S/c1-12-8-13(10-23)11-25-17(12)18(29)26-14-4-5-16(22)15(9-14)20(2)21(6-7-21)32(30,31)28(3)19(24)27-20/h4-5,8-9,11H,6-7H2,1-3H3,(H2,24,27)(H,26,29)/t20-/m1/s1	NGRPNJWYIZOAPX-HXUWFJFHSA-N	352255	US9802928, 1k	Beta-secretase 2		 5.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352255&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189965	386046660							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700291	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccn(n3)C(F)F)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C18H19F3N6O3S/c1-17(18(6-7-18)31(29,30)26(2)16(22)24-17)11-9-10(3-4-12(11)19)23-14(28)13-5-8-27(25-13)15(20)21/h3-5,8-9,15H,6-7H2,1-2H3,(H2,22,24)(H,23,28)/t17-/m1/s1	UIDKDNIVBINBTH-QGZVFWFLSA-N	352256	US9802928, 1l	Beta-secretase 2		 2.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189964	386046661							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700293	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cn4ccc(cc4n3)C#N)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C22H20FN7O3S/c1-21(22(6-7-22)34(32,33)29(2)20(25)28-21)15-10-14(3-4-16(15)23)26-19(31)17-12-30-8-5-13(11-24)9-18(30)27-17/h3-5,8-10,12H,6-7H2,1-2H3,(H2,25,28)(H,26,31)/t21-/m1/s1	SFQMOEHIAYEQHB-OAQYLSRUSA-N	352257	US9802928, 1m	Beta-secretase 2		 1640								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189951	386046662							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700295	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cc(C)on3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C18H20FN5O4S/c1-10-8-14(23-28-10)15(25)21-11-4-5-13(19)12(9-11)17(2)18(6-7-18)29(26,27)24(3)16(20)22-17/h4-5,8-9H,6-7H2,1-3H3,(H2,20,22)(H,21,25)/t17-/m1/s1	DOPZIBGZSVWPJQ-QGZVFWFLSA-N	352258	US9802928, 1n	Beta-secretase 2		 220								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352258&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189966	386046663							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700297	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ncc(Cl)cc3F)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18ClF2N5O3S/c1-18(19(5-6-19)31(29,30)27(2)17(23)26-18)12-8-11(3-4-13(12)21)25-16(28)15-14(22)7-10(20)9-24-15/h3-4,7-9H,5-6H2,1-2H3,(H2,23,26)(H,25,28)/t18-/m1/s1	VSEIQOKNGNMHNG-GOSISDBHSA-N	352259	US9802928, 1o	Beta-secretase 2		 3.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352259&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189949	386046664							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700299	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cnc(cn3)C(F)(F)F)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18F4N6O3S/c1-17(18(5-6-18)33(31,32)29(2)16(24)28-17)11-7-10(3-4-12(11)20)27-15(30)13-8-26-14(9-25-13)19(21,22)23/h3-4,7-9H,5-6H2,1-2H3,(H2,24,28)(H,27,30)/t17-/m1/s1	DRANDICUZDZDQQ-QGZVFWFLSA-N	352260	US9802928, 1p	Beta-secretase 2		 346								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352260&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189952	386046665							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700301	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@@]2(C)NC(=N)N(C)S(=O)(=O)C22CC2)c(C)n1	InChI=1S/C20H23FN6O4S/c1-11-16(23-10-15(24-11)31-4)17(28)25-12-5-6-14(21)13(9-12)19(2)20(7-8-20)32(29,30)27(3)18(22)26-19/h5-6,9-10H,7-8H2,1-4H3,(H2,22,26)(H,25,28)/t19-/m1/s1	HYSVXKHVNMBZKC-LJQANCHMSA-N	352261	US9802928, 1q	Beta-secretase 2		 41.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118190241	386046666							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700303	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H19F2N5O3S/c1-18(19(7-8-19)30(28,29)26(2)17(22)25-18)13-9-12(4-5-14(13)21)24-16(27)15-6-3-11(20)10-23-15/h3-6,9-10H,7-8H2,1-2H3,(H2,22,25)(H,24,27)/t18-/m1/s1	UKNSROGMIYSAQF-GOSISDBHSA-N	352262	US9802928, 1r	Beta-secretase 2		 8.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118190074	386046667							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700305	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C20H20F3N5O4S/c1-19(20(7-8-20)33(30,31)28(2)18(24)27-19)13-9-11(3-5-14(13)21)26-16(29)15-6-4-12(10-25-15)32-17(22)23/h3-6,9-10,17H,7-8H2,1-2H3,(H2,24,27)(H,26,29)/t19-/m1/s1	FDFUFJNRMIIKEA-LJQANCHMSA-N	352263	US9802928, 1s	Beta-secretase 2		 46.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352263&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118190076	386046668							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700307	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cnc(OCCF)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C20H22F2N6O4S/c1-19(20(5-6-20)33(30,31)28(2)18(23)27-19)13-9-12(3-4-14(13)22)26-17(29)15-10-25-16(11-24-15)32-8-7-21/h3-4,9-11H,5-8H2,1-2H3,(H2,23,27)(H,26,29)/t19-/m1/s1	OQMQSAHHJNGMTN-LJQANCHMSA-N	352264	US9802928, 1t	Beta-secretase 2		 285								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118190075	386046669							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700309	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3nc(C)oc3C)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H22FN5O4S/c1-10-15(22-11(2)29-10)16(26)23-12-5-6-14(20)13(9-12)18(3)19(7-8-19)30(27,28)25(4)17(21)24-18/h5-6,9H,7-8H2,1-4H3,(H2,21,24)(H,23,26)/t18-/m1/s1	TVCGECNZTOJGPF-GOSISDBHSA-N	352265	US9802928, 1u	Beta-secretase 2		 8.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352265&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118190073	386046670							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700311	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cn4ccsc4n3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H19FN6O3S2/c1-18(19(5-6-19)31(28,29)25(2)16(21)24-18)12-9-11(3-4-13(12)20)22-15(27)14-10-26-7-8-30-17(26)23-14/h3-4,7-10H,5-6H2,1-2H3,(H2,21,24)(H,22,27)/t18-/m1/s1	JGOCKNBMGPOZHH-GOSISDBHSA-N	352266	US9802928, 1v	Beta-secretase 2		 63.0								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352266&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189960	386046671							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700313	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3cnc(OCC(F)(F)F)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C20H20F4N6O4S/c1-18(19(5-6-19)35(32,33)30(2)17(25)29-18)12-7-11(3-4-13(12)21)28-16(31)14-8-27-15(9-26-14)34-10-20(22,23)24/h3-4,7-9H,5-6,10H2,1-2H3,(H2,25,29)(H,28,31)/t18-/m1/s1	NGKDQMRAUSDSAI-GOSISDBHSA-N	352267	US9802928, 1w	Beta-secretase 2		 159								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352267&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189959	386046672							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
700315	CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H19ClFN5O3S/c1-18(19(7-8-19)30(28,29)26(2)17(22)25-18)13-9-12(4-5-14(13)21)24-16(27)15-6-3-11(20)10-23-15/h3-6,9-10H,7-8H2,1-2H3,(H2,22,25)(H,24,27)/t18-/m1/s1	GMFWGHDWPHXEOU-GOSISDBHSA-N	352268	US9802928, 2	Beta-secretase 2		 2.00								US Patent		10.7270/Q21Z46K6		aid1797559	US9802928	Scott, JD; Cumming, JN; Blizzard, T; Ellis, M	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=352268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=352268&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118189954	386046673							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739763	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)NCC(F)F)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C22H18F4N6OS/c1-21(16-6-22(16,34-20(28)32-21)19(33)31-10-17(24)25)13-4-12(9-30-18(13)26)5-14(23)15-3-2-11(7-27)8-29-15/h2-5,8-9,16-17H,6,10H2,1H3,(H2,28,32)(H,31,33)/b14-5-/t16-,21+,22-/m0/s1	YYCRMOQCZHPARY-FXUMXNMGSA-N	372874	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-N-(2,2-difluoroethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 281	Beta-secretase 2			 164							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372874&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285452	402359809							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739766	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)cnc1F	InChI=1S/C22H21F5N6O2S/c1-20(15-6-21(15,18(34)33(2)3)36-19(28)32-20)12-4-11(7-31-17(12)24)5-13(23)14-8-30-16(9-29-14)35-10-22(25,26)27/h4-5,7-9,15H,6,10H2,1-3H3,(H2,28,32)/b13-5-/t15-,20+,21-/m0/s1	BPVUVMIIWOKSLJ-CWXICVBYSA-N	372875	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,2-trifluoroethoxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 282	Beta-secretase 2			 125							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372875&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524435	402359810							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739769	C[C@@H]1COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C26H26F2N6O3S/c1-4-6-37-21-13-30-19(12-31-21)18(27)9-16-8-17(22(28)32-11-16)25(3)20-10-26(20,38-24(29)33-25)23(35)34-5-7-36-14-15(34)2/h1,8-9,11-13,15,20H,5-7,10,14H2,2-3H3,(H2,29,33)/b18-9-/t15-,20+,25-,26+/m1/s1	JKANPSVTEJTQKV-XPQRKTGASA-N	372876	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((R)-3-methylmorpholino)methanone::US10246429, Example 283	Beta-secretase 2			 375							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372876&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285395	402359811							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739772	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1[C@H]2COC[C@@H]1COC2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C27H26F2N6O4S/c1-3-4-39-22-10-31-20(9-32-22)19(28)6-15-5-18(23(29)33-8-15)26(2)21-7-27(21,40-25(30)34-26)24(36)35-16-11-37-13-17(35)14-38-12-16/h1,5-6,8-10,16-17,21H,4,7,11-14H2,2H3,(H2,30,34)/b19-6-/t16?,17?,21-,26+,27-/m0/s1	XQGARPKKWYXACW-MWCZSRNESA-N	372877	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((1R,5R)-3,7-dioxa-9-azabicyclo[3.3.1]nonan-9-yl)methanone::US10246429, Example 284	Beta-secretase 2			 255							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285414	402359812							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739775	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C21H17F2N5O3S/c1-3-4-31-16-10-25-14(9-26-16)13(22)6-11-5-12(17(23)27-8-11)20(2)15-7-21(15,18(29)30)32-19(24)28-20/h1,5-6,8-10,15H,4,7H2,2H3,(H2,24,28)(H,29,30)/b13-6-/t15-,20+,21-/m0/s1	GZOBJDKSMWPUCB-PJHMGBBRSA-N	372878	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylic acid::US10246429, Example 285	Beta-secretase 2			 6350							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372878&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555022	402359813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739778	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H20ClF2N3OS/c1-20(18-9-21(18,11-28-2)29-19(25)27-20)14-7-12(3-5-15(14)23)8-16(24)17-6-4-13(22)10-26-17/h3-8,10,18H,9,11H2,1-2H3,(H2,25,27)/b16-8-/t18-,20+,21+/m0/s1	QJTYANIDYNXYQH-WYVHCHOOSA-N	372879	(1S,5S,6S)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 286	Beta-secretase 2			 69.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372879&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555099	402359814							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739781	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C23H22F2N6O2S/c1-5-6-33-18-12-27-16(11-28-18)15(24)8-13-7-14(19(25)29-10-13)22(2)17-9-23(17,20(32)31(3)4)34-21(26)30-22/h1,7-8,10-12,17H,6,9H2,2-4H3,(H2,26,30)/b15-8-/t17-,22+,23-/m0/s1	QARZSAHNYVWRSL-FEHPPSAASA-N	372881	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 287	Beta-secretase 2			 40.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372881&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285483	402359816							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739784	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(C)=O)cn2)cnc1F	InChI=1S/C23H24F2N6O3S/c1-12(32)11-34-18-10-27-16(9-28-18)15(24)6-13-5-14(19(25)29-8-13)22(2)17-7-23(17,20(33)31(3)4)35-21(26)30-22/h5-6,8-10,17H,7,11H2,1-4H3,(H2,26,30)/b15-6-/t17-,22+,23-/m0/s1	RFAZLBCCEUZJRG-IIRCZYLOSA-N	372882	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2-oxopropoxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 288	Beta-secretase 2			 294							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372882&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285436	402359817							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739787	CC#CCOc1cnc(cn1)C(\F)=C\c1cnc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N(C)C	InChI=1S/C24H24F2N6O2S/c1-5-6-7-34-19-13-28-17(12-29-19)16(25)9-14-8-15(20(26)30-11-14)23(2)18-10-24(18,21(33)32(3)4)35-22(27)31-23/h8-9,11-13,18H,7,10H2,1-4H3,(H2,27,31)/b16-9-/t18-,23+,24-/m0/s1	SASREFBZYITCBN-DEKDSERASA-N	372883	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 289	Beta-secretase 2			 22.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372883&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285422	402359818							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739790	C[C@@H]1COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C25H24F2N6O2S/c1-14-13-35-6-5-33(14)22(34)25-9-20(25)24(2,32-23(29)36-25)17-7-16(12-31-21(17)27)8-18(26)19-4-3-15(10-28)11-30-19/h3-4,7-8,11-12,14,20H,5-6,9,13H2,1-2H3,(H2,29,32)/b18-8-/t14-,20+,24-,25+/m1/s1	JCSLWTXLMPNZAK-GAUIWLPGSA-N	372884	6-((Z)-2-(5-((1S,5S,6S)-3-amino-5-methyl-1-((R)-3-methylmorpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 290	Beta-secretase 2			 229							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372884&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285465	402359819							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739793	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)(F)C(F)F)cn2)cnc1F	InChI=1S/C23H22F6N6O2S/c1-21(15-6-22(15,19(36)35(2)3)38-20(30)34-21)12-4-11(7-33-17(12)25)5-13(24)14-8-32-16(9-31-14)37-10-23(28,29)18(26)27/h4-5,7-9,15,18H,6,10H2,1-3H3,(H2,30,34)/b13-5-/t15-,21+,22-/m0/s1	QAWFDOHXDZMIJD-WCAZPXQRSA-N	372885	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-tetrafluoropropoxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 291	Beta-secretase 2			 106							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372885&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285490	402359820							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739796	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C26H25F2N5O3S/c1-3-8-36-22-15-30-20(14-31-22)19(28)12-16-4-5-18(27)17(11-16)25(2)21-13-26(21,37-24(29)32-25)23(34)33-6-9-35-10-7-33/h1,4-5,11-12,14-15,21H,6-10,13H2,2H3,(H2,29,32)/b19-12-/t21-,25+,26-/m0/s1	CJZWMPMJEVFVLS-QBIJIEJISA-N	372886	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 292	Beta-secretase 2			 100.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372886&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557050	402359821							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739799	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H20F2N4OS/c1-21(19-9-22(19,12-29-2)30-20(26)28-21)15-7-13(3-5-16(15)23)8-17(24)18-6-4-14(10-25)11-27-18/h3-8,11,19H,9,12H2,1-2H3,(H2,26,28)/b17-8-/t19-,21+,22+/m0/s1	OBIFLVXHXRJOKM-FQRJWFRCSA-N	372887	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 293	Beta-secretase 2			 192							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372887&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523873	402359822							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739802	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C22H19F2N5O3S/c1-4-5-32-17-11-26-15(10-27-17)14(23)7-12-6-13(18(24)28-9-12)21(2)16-8-22(16,19(30)31-3)33-20(25)29-21/h1,6-7,9-11,16H,5,8H2,2-3H3,(H2,25,29)/b14-7-/t16-,21+,22-/m0/s1	ZRXUXWQFQQWSLZ-XULIFMQASA-N	372888	(1S,5S,6S)-methyl 3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate methanone::US10246429, Example 294	Beta-secretase 2			 2760							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372888&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557639	402359823							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739805	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H](F)C1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C25H23F3N6O2S/c1-3-6-36-20-12-30-18(11-31-20)17(27)8-14-7-16(21(28)32-10-14)24(2)19-9-25(19,37-23(29)33-24)22(35)34-5-4-15(26)13-34/h1,7-8,10-12,15,19H,4-6,9,13H2,2H3,(H2,29,33)/b17-8-/t15-,19+,24-,25+/m1/s1	VIRFKBOLQBPCOG-YTQMNEKISA-N	372889	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((R)-3-fluoropyrrolidin-1-yl)methanone::US10246429, Example 295	Beta-secretase 2			 78.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372889&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285417	402359824							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739808	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#N)cnc1F	InChI=1S/C21H19F2N7OS/c1-20(16-6-21(16,18(31)30(2)3)32-19(25)29-20)13-4-11(8-28-17(13)23)5-14(22)15-10-26-12(7-24)9-27-15/h4-5,8-10,16H,6H2,1-3H3,(H2,25,29)/b14-5-/t16-,20+,21-/m0/s1	XDROLWNSUUTKLM-RWBWBGHRSA-N	372890	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyrazin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 296	Beta-secretase 2			 37.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372890&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558791	402359825							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739811	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H](F)C1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C26H24F3N5O2S/c1-3-8-36-22-13-31-20(12-32-22)19(29)10-15-4-5-18(28)17(9-15)25(2)21-11-26(21,37-24(30)33-25)23(35)34-7-6-16(27)14-34/h1,4-5,9-10,12-13,16,21H,6-8,11,14H2,2H3,(H2,30,33)/b19-10-/t16-,21+,25-,26+/m1/s1	YLLZTZREIRJLLF-OGGGKMIRSA-N	372891	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((R)-3-fluoropyrrolidin-1-yl)methanone::US10246429, Example 297	Beta-secretase 2			 41.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372891&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285415	402359826							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739814	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1[C@H]2COC[C@@H]1COC2)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C26H24F2N6O3S/c1-25(18-4-15(9-32-22(18)28)5-19(27)20-3-2-14(7-29)8-31-20)21-6-26(21,38-24(30)33-25)23(35)34-16-10-36-12-17(34)13-37-11-16/h2-5,8-9,16-17,21H,6,10-13H2,1H3,(H2,30,33)/b19-5-/t16?,17?,21-,25+,26-/m0/s1	DOAYGPXPPWHUOR-LQVZRUJSSA-N	372892	6-((Z)-2-(5-((1S,5S,6S)-3-amino-1-((1R,5R)-3,7-dioxa-9-azabicyclo[3.3.1]nonane-9-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 298	Beta-secretase 2			 108							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372892&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285409	402359827							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739817	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C21H19F2N5OS/c1-20(18-7-21(18,11-29-2)30-19(25)28-20)14-5-12(3-4-15(14)22)6-16(23)17-10-26-13(8-24)9-27-17/h3-6,9-10,18H,7,11H2,1-2H3,(H2,25,28)/b16-6-/t18-,20+,21+/m0/s1	ZJFWPRDOUZWEBL-YXTORIBGSA-N	372893	5-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile::US10246429, Example 299	Beta-secretase 2			 259							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372893&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557060	402359828							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739820	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)NCC(F)F)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C23H20F4N6O2S/c1-3-4-35-18-11-29-15(9-30-18)14(24)6-12-5-13(19(27)31-8-12)22(2)16-7-23(16,36-21(28)33-22)20(34)32-10-17(25)26/h1,5-6,8-9,11,16-17H,4,7,10H2,2H3,(H2,28,33)(H,32,34)/b14-6-/t16-,22+,23-/m0/s1	MBHAWZUOENKHQB-JHSRIWHPSA-N	372894	(1S,5S,6S)-3-amino-N-(2,2-difluoroethyl)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 300	Beta-secretase 2			 411							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372894&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285404	402359829							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739260	COC[C@]12C[C@H]1[C@](CF)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H19ClF3N3OS/c1-29-11-20-8-18(20)21(10-23,28-19(26)30-20)14-6-12(2-4-15(14)24)7-16(25)17-5-3-13(22)9-27-17/h2-7,9,18H,8,10-11H2,1H3,(H2,26,28)/b16-7-/t18-,20-,21-/m1/s1	DGFXDPYXKFNNAW-RPXRUMITSA-N	372696	(1S,5S,6S)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-(fluoromethyl)-1-(methoxymethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 100	Beta-secretase 2			 42.1							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372696	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372696&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524156	402359632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739263	COC[C@]12C[C@H]1[C@](CF)(N=C(N)S2)c1cc(\C=C(\F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H19ClF3N3OS/c1-29-11-20-8-18(20)21(10-23,28-19(26)30-20)14-6-12(2-4-15(14)24)7-16(25)17-5-3-13(22)9-27-17/h2-7,9,18H,8,10-11H2,1H3,(H2,26,28)/b16-7+/t18-,20-,21-/m1/s1	DGFXDPYXKFNNAW-VDTLHJFLSA-N	372697	(1S,5S,6S)-5-(5-((E)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-(fluoromethyl)-1-(methoxymethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 101	Beta-secretase 2			 281							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372697	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372697&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524829	402359633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739266	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C22H21ClF2N4OS/c1-21(18-10-22(18,19(30)29(2)3)31-20(26)28-21)14-8-12(4-6-15(14)24)9-16(25)17-7-5-13(23)11-27-17/h4-9,11,18H,10H2,1-3H3,(H2,26,28)/b16-9-/t18-,21+,22-/m0/s1	WDEGRKJIJHXYSL-LLYJTOGPSA-N	372698	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 102	Beta-secretase 2			 2.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372698	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372698&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557034	402359634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739269	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H23ClF2N4OS/c1-23(20-12-24(20,33-22(28)30-23)21(32)31-8-2-3-9-31)16-10-14(4-6-17(16)26)11-18(27)19-7-5-15(25)13-29-19/h4-7,10-11,13,20H,2-3,8-9,12H2,1H3,(H2,28,30)/b18-11-/t20-,23+,24-/m0/s1	XUGARFJMQNSIGG-JXOCDECTSA-N	372699	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(pyrrolidin-1-yl)methanone::US10246429, Example 103	Beta-secretase 2			 5.97							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372699	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372699&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556982	402359635							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739272	COc1ccc(nc1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC1	InChI=1S/C25H26F2N4O2S/c1-24(21-13-25(21,34-23(28)30-24)22(32)31-9-3-4-10-31)17-11-15(5-7-18(17)26)12-19(27)20-8-6-16(33-2)14-29-20/h5-8,11-12,14,21H,3-4,9-10,13H2,1-2H3,(H2,28,30)/b19-12-/t21-,24+,25-/m0/s1	YOAUIBLLTVYUGO-BJOHRBRLSA-N	372700	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-methoxypyridin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(pyrrolidin-1-yl)methanone::US10246429, Example 104	Beta-secretase 2			 144							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372700	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372700&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556776	402359636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739275	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F	InChI=1S/C21H18BrF2N3O2S/c1-20(17-9-21(17,18(28)29-2)30-19(25)27-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(22)10-26-16/h3-8,10,17H,9H2,1-2H3,(H2,25,27)/b15-8-/t17-,20+,21-/m0/s1	NAVNVHWZYSPMIE-NZUJZPRYSA-N	372701	(1S,5S,6S)-methyl 3-amino-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 105	Beta-secretase 2			 127							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372701	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372701&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558743	402359637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739278	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C23H21F2N5OS/c1-22(19-10-23(19,20(31)30(2)3)32-21(27)29-22)15-8-13(4-6-16(15)24)9-17(25)18-7-5-14(11-26)12-28-18/h4-9,12,19H,10H2,1-3H3,(H2,27,29)/b17-9-/t19-,22+,23-/m0/s1	JZDMWPTVBRAJMZ-OZNMDXOXSA-N	372702	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 106	Beta-secretase 2			 14.3							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372702	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372702&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557036	402359638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739281	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H23F2N5OS/c1-24(21-12-25(21,34-23(29)31-24)22(33)32-8-2-3-9-32)17-10-15(4-6-18(17)26)11-19(27)20-7-5-16(13-28)14-30-20/h4-7,10-11,14,21H,2-3,8-9,12H2,1H3,(H2,29,31)/b19-11-/t21-,24+,25-/m0/s1	BVIPSJSEJQGVKV-MYMUPAQMSA-N	372703	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(pyrrolidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 107	Beta-secretase 2			 24.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372703	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372703&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524148	402359639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739284	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F	InChI=1S/C22H21BrF2N4OS/c1-21(18-10-22(18,19(30)29(2)3)31-20(26)28-21)14-8-12(4-6-15(14)24)9-16(25)17-7-5-13(23)11-27-17/h4-9,11,18H,10H2,1-3H3,(H2,26,28)/b16-9-/t18-,21+,22-/m0/s1	JEZBKOATHZHSCP-LLYJTOGPSA-N	372704	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 108	Beta-secretase 2			 2.92							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372704	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372704&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556778	402359640							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739287	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#CC2CC2)ccc1F	InChI=1S/C27H26F2N4OS/c1-26(23-14-27(23,24(34)33(2)3)35-25(30)32-26)19-12-18(8-10-20(19)28)13-21(29)22-11-9-17(15-31-22)7-6-16-4-5-16/h8-13,15-16,23H,4-5,14H2,1-3H3,(H2,30,32)/b21-13-/t23-,26+,27-/m0/s1	SZZGETRLWMCVJX-PGXJAGERSA-N	372705	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyclopropylethynyl)pyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 109	Beta-secretase 2			 61.5							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372705	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372705&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557047	402359641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739290	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#C)ccc1F	InChI=1S/C24H22F2N4OS/c1-5-14-7-9-19(28-13-14)18(26)11-15-6-8-17(25)16(10-15)23(2)20-12-24(20,21(31)30(3)4)32-22(27)29-23/h1,6-11,13,20H,12H2,2-4H3,(H2,27,29)/b18-11-/t20-,23+,24-/m0/s1	DLBWKNCRWZWDQQ-JXOCDECTSA-N	372706	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-ethynylpyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 110	Beta-secretase 2			 14.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372706	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372706&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285450	402359642							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739293	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H18ClF2N3O2S/c1-20(17-9-21(17,18(28)29-2)30-19(25)27-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(22)10-26-16/h3-8,10,17H,9H2,1-2H3,(H2,25,27)/b15-8-/t17-,20+,21-/m0/s1	MRYONVWXWKVXGY-NZUJZPRYSA-N	372707	(1S,5S,6S)-methyl 3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 111	Beta-secretase 2			 102							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372707	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372707&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558744	402359643							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739296	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C23H21ClF2N4OS/c1-22(19-11-23(19,32-21(27)29-22)20(31)30-7-2-8-30)15-9-13(3-5-16(15)25)10-17(26)18-6-4-14(24)12-28-18/h3-6,9-10,12,19H,2,7-8,11H2,1H3,(H2,27,29)/b17-10-/t19-,22+,23-/m0/s1	CTGDPCAUHWPMSQ-NKUXOPIZSA-N	372708	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(azetidin-1-yl)methanone::US10246429, Example 112	Beta-secretase 2			 6.72							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372708	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372708&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558747	402359644							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739299	C[C@@]1(N=C(N)S[C@@]2(CO)C[C@@H]12)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H18ClF2N3OS/c1-19(17-8-20(17,10-27)28-18(24)26-19)13-6-11(2-4-14(13)22)7-15(23)16-5-3-12(21)9-25-16/h2-7,9,17,27H,8,10H2,1H3,(H2,24,26)/b15-7-/t17-,19+,20+/m0/s1	JVSPQAGFOFURHW-QMSWDQOWSA-N	372709	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)methanol::US10246429, Example 113	Beta-secretase 2			 33.9							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372709	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372709&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556780	402359645							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739302	C[C@@]1(N=C(N)S[C@@]2(CC#N)C[C@@H]12)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H17ClF2N4S/c1-20(18-10-21(18,6-7-25)29-19(26)28-20)14-8-12(2-4-15(14)23)9-16(24)17-5-3-13(22)11-27-17/h2-5,8-9,11,18H,6,10H2,1H3,(H2,26,28)/b16-9-/t18-,20+,21-/m0/s1	ACDPGWGMCNPVMI-JYTMSLEBSA-N	372710	2-((1R,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)acetonitrile::US10246429, Example 114	Beta-secretase 2			 55.5							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372710&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557054	402359646							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739305	CC(O)CCNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H25ClF2N4O2S/c1-13(32)7-8-29-21(33)24-11-20(24)23(2,31-22(28)34-24)16-9-14(3-5-17(16)26)10-18(27)19-6-4-15(25)12-30-19/h3-6,9-10,12-13,20,32H,7-8,11H2,1-2H3,(H2,28,31)(H,29,33)/b18-10-/t13?,20-,23+,24-/m0/s1	KPXIRWMBYIHURD-OADSIHPSSA-N	372711	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N-(3-hydroxybutyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 115	Beta-secretase 2			 8.35							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372711	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372711&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557057	402359647							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739308	CC1CCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H23ClF2N4OS/c1-13-7-8-31(13)21(32)24-11-20(24)23(2,30-22(28)33-24)16-9-14(3-5-17(16)26)10-18(27)19-6-4-15(25)12-29-19/h3-6,9-10,12-13,20H,7-8,11H2,1-2H3,(H2,28,30)/b18-10-/t13?,20-,23+,24-/m0/s1	DHQPJSRTYUHTOL-OADSIHPSSA-N	372712	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(2-methylazetidin-1-yl)methanone::US10246429, Example 116	Beta-secretase 2			 11.9							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372712&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557109	402359648							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739311	COC[C@@H]1CCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C26H27ClF2N4O2S/c1-25(18-10-15(5-7-19(18)28)11-20(29)21-8-6-16(27)13-31-21)22-12-26(22,36-24(30)32-25)23(34)33-9-3-4-17(33)14-35-2/h5-8,10-11,13,17,22H,3-4,9,12,14H2,1-2H3,(H2,30,32)/b20-11-/t17-,22-,25+,26-/m0/s1	RGUOHKUAYMYLSM-GNKRUJPDSA-N	372713	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone::US10246429, Example 117	Beta-secretase 2			 20.9							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372713&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557477	402359649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739314	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)Nc1ccccc1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C26H21ClF2N4OS/c1-25(18-11-15(7-9-19(18)28)12-20(29)21-10-8-16(27)14-31-21)22-13-26(22,35-24(30)33-25)23(34)32-17-5-3-2-4-6-17/h2-12,14,22H,13H2,1H3,(H2,30,33)(H,32,34)/b20-12-/t22-,25+,26-/m0/s1	XEIRWLNICFKQIW-VPLUUOPTSA-N	372714	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-N-phenyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 118	Beta-secretase 2			 47.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372714	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372714&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557480	402359650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739317	C[C@H]1CCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H23ClF2N4OS/c1-13-7-8-31(13)21(32)24-11-20(24)23(2,30-22(28)33-24)16-9-14(3-5-17(16)26)10-18(27)19-6-4-15(25)12-29-19/h3-6,9-10,12-13,20H,7-8,11H2,1-2H3,(H2,28,30)/b18-10-/t13-,20-,23+,24-/m0/s1	DHQPJSRTYUHTOL-HPUSVVHXSA-N	372715	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((S)-2-methylazetidin-1-yl)methanone::US10246429, Example 119	Beta-secretase 2			 7.52							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372715	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372715&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557113	402359651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739823	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C25H24F2N6O3S/c1-3-6-36-20-14-29-18(13-30-20)17(26)10-15-9-16(21(27)31-12-15)24(2)19-11-25(19,37-23(28)32-24)22(34)33-4-7-35-8-5-33/h1,9-10,12-14,19H,4-8,11H2,2H3,(H2,28,32)/b17-10-/t19-,24+,25-/m0/s1	BCTKVJVJCJQKOO-FWQJVDQLSA-N	372895	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 301	Beta-secretase 2			 309							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372895&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557059	402359830							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739826	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)NCC(F)F)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C24H21F4N5O2S/c1-3-6-35-20-12-30-17(10-31-20)16(26)8-13-4-5-15(25)14(7-13)23(2)18-9-24(18,36-22(29)33-23)21(34)32-11-19(27)28/h1,4-5,7-8,10,12,18-19H,6,9,11H2,2H3,(H2,29,33)(H,32,34)/b16-8-/t18-,23+,24-/m0/s1	OMRBGNNPYNAVLS-GWSKSGCMSA-N	372896	(1S,5S,6S)-3-amino-N-(2,2-difluoroethyl)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 302	Beta-secretase 2			 109							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372896&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557091	402359831							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739829	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@H](F)C1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C26H24F3N5O2S/c1-3-8-36-22-13-31-20(12-32-22)19(29)10-15-4-5-18(28)17(9-15)25(2)21-11-26(21,37-24(30)33-25)23(35)34-7-6-16(27)14-34/h1,4-5,9-10,12-13,16,21H,6-8,11,14H2,2H3,(H2,30,33)/b19-10-/t16-,21-,25+,26-/m0/s1	YLLZTZREIRJLLF-GOODSBEGSA-N	372897	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((S)-3-fluoropyrrolidin-1-yl)methanone::US10246429, Example 303	Beta-secretase 2			 93.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372897&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285429	402359832							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739832	C[C@@H]1COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C27H27F2N5O3S/c1-4-8-37-23-14-31-21(13-32-23)20(29)11-17-5-6-19(28)18(10-17)26(3)22-12-27(22,38-25(30)33-26)24(35)34-7-9-36-15-16(34)2/h1,5-6,10-11,13-14,16,22H,7-9,12,15H2,2-3H3,(H2,30,33)/b20-11-/t16-,22+,26-,27+/m1/s1	JSGSQFIXRWAYDP-CSBZHDBQSA-N	372898	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((R)-3-methylmorpholino)methanone::US10246429, Example 304	Beta-secretase 2			 290							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372898&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558800	402359833							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739835	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cc3OCCOc3cn2)ccc1F	InChI=1S/C23H23F2N3O3S/c1-22(20-10-23(20,12-29-2)32-21(26)28-22)14-7-13(3-4-15(14)24)8-16(25)17-9-18-19(11-27-17)31-6-5-30-18/h3-4,7-9,11,20H,5-6,10,12H2,1-2H3,(H2,26,28)/b16-8-/t20-,22+,23+/m0/s1	XEBSJKGULZALCC-JEXWFEAASA-N	372899	(1S,5S,6S)-5-(5-((Z)-2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-2-fluorovinyl)-2-fluorophenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 305	Beta-secretase 2			 373							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372899&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285382	402359834							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739838	C[C@H]1[C@@H](F)CCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H24F3N5OS/c1-14-18(27)7-8-34(14)23(35)26-11-22(26)25(2,33-24(31)36-26)17-9-15(3-5-19(17)28)10-20(29)21-6-4-16(12-30)13-32-21/h3-6,9-10,13-14,18,22H,7-8,11H2,1-2H3,(H2,31,33)/b20-10-/t14-,18-,22-,25+,26-/m0/s1	DFYAUWDSHXLSJC-WGIYXMAXSA-N	372900	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((2S,3S)-3-fluoro-2-methylpyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 306	Beta-secretase 2			 111							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372900&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523867	402359835							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739841	C[C@@H]1[C@H](F)CCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H24F3N5OS/c1-14-18(27)7-8-34(14)23(35)26-11-22(26)25(2,33-24(31)36-26)17-9-15(3-5-19(17)28)10-20(29)21-6-4-16(12-30)13-32-21/h3-6,9-10,13-14,18,22H,7-8,11H2,1-2H3,(H2,31,33)/b20-10-/t14-,18-,22+,25-,26+/m1/s1	DFYAUWDSHXLSJC-OJNSPYEBSA-N	372901	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((2R,3R)-3-fluoro-2-methylpyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 307	Beta-secretase 2			 100.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372901&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523950	402359836							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739844	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOC2(COC2)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H25F2N5O3S/c1-25(18-8-16(2-4-19(18)28)9-20(29)21-5-3-17(11-30)12-32-21)22-10-27(22,38-24(31)33-25)23(35)34-6-7-37-26(13-34)14-36-15-26/h2-5,8-9,12,22H,6-7,10,13-15H2,1H3,(H2,31,33)/b20-9-/t22-,25+,27-/m0/s1	WYHSXLPYCWHUCK-YNXNWOFFSA-N	372902	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(2,5-dioxa-8-azaspiro[3.5]nonane-8-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 308	Beta-secretase 2			 13.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372902&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557766	402359837							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739847	C[C@]1(O)CCN(C1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H25F2N5O2S/c1-24(35)7-8-33(14-24)22(34)26-11-21(26)25(2,32-23(30)36-26)17-9-15(3-5-18(17)27)10-19(28)20-6-4-16(12-29)13-31-20/h3-6,9-10,13,21,35H,7-8,11,14H2,1-2H3,(H2,30,32)/b19-10-/t21-,24-,25+,26-/m0/s1	ACNOVNMEJRDKTF-QAWPSLBMSA-N	372903	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-hydroxy-3-methylpyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 309::US10246429, Example 310	Beta-secretase 2			 7.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372903&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557237	402359838							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739850	C[C@]1(O)CCN(C1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H25F2N5O2S/c1-24(35)7-8-33(14-24)22(34)26-11-21(26)25(2,32-23(30)36-26)17-9-15(3-5-18(17)27)10-19(28)20-6-4-16(12-29)13-31-20/h3-6,9-10,13,21,35H,7-8,11,14H2,1-2H3,(H2,30,32)/b19-10-/t21-,24-,25+,26-/m0/s1	ACNOVNMEJRDKTF-QAWPSLBMSA-N	372903	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-hydroxy-3-methylpyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 309::US10246429, Example 310	Beta-secretase 2			 41.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372903&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557237	402359838							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739853	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCO[C@H]2C[C@@H]12)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H23F2N5O2S/c1-25(16-8-14(2-4-17(16)27)9-18(28)19-5-3-15(12-29)13-31-19)22-11-26(22,36-24(30)32-25)23(34)33-6-7-35-21-10-20(21)33/h2-5,8-9,13,20-22H,6-7,10-11H2,1H3,(H2,30,32)/b18-9-/t20-,21+,22+,25-,26+/m1/s1	XYFWWLGMDVICID-DLQDBSQJSA-N	372905	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((1S,6R)-2-oxa-5-azabicyclo[4.1.0]heptane-5-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 311::US10246429, Example 312	Beta-secretase 2			 48.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372905&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285449	402359839							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739856	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCO[C@H]2C[C@@H]12)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H23F2N5O2S/c1-25(16-8-14(2-4-17(16)27)9-18(28)19-5-3-15(12-29)13-31-19)22-11-26(22,36-24(30)32-25)23(34)33-6-7-35-21-10-20(21)33/h2-5,8-9,13,20-22H,6-7,10-11H2,1H3,(H2,30,32)/b18-9-/t20-,21+,22+,25-,26+/m1/s1	XYFWWLGMDVICID-DLQDBSQJSA-N	372905	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((1S,6R)-2-oxa-5-azabicyclo[4.1.0]heptane-5-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 311::US10246429, Example 312	Beta-secretase 2			 68.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372905&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285449	402359839							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739859	C[C@H]1COC[C@@H](C)N1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-15-13-36-14-16(2)34(15)24(35)27-10-23(27)26(3,33-25(31)37-27)19-8-17(4-6-20(19)28)9-21(29)22-7-5-18(11-30)12-32-22/h4-9,12,15-16,23H,10,13-14H2,1-3H3,(H2,31,33)/b21-9-/t15-,16+,23-,26+,27-/m0/s1	QHATUSKGDTYXBK-CRCIOUFOSA-N	372907	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((3S,5R)-3,5-dimethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 313	Beta-secretase 2			 147							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372907&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557242	402359840							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739862	C[C@@H]1COC[C@@H](C)N1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-15-13-36-14-16(2)34(15)24(35)27-10-23(27)26(3,33-25(31)37-27)19-8-17(4-6-20(19)28)9-21(29)22-7-5-18(11-30)12-32-22/h4-9,12,15-16,23H,10,13-14H2,1-3H3,(H2,31,33)/b21-9-/t15-,16-,23+,26-,27+/m1/s1	QHATUSKGDTYXBK-LFDWGKEUSA-N	372908	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((3R,5R)-3,5-dimethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 314	Beta-secretase 2			 240							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372908&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556900	402359841							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739865	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1C2CCC1COC2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H25F2N5O2S/c1-26(19-8-15(2-6-20(19)28)9-21(29)22-7-3-16(11-30)12-32-22)23-10-27(23,37-25(31)33-26)24(35)34-17-4-5-18(34)14-36-13-17/h2-3,6-9,12,17-18,23H,4-5,10,13-14H2,1H3,(H2,31,33)/b21-9-/t17?,18?,23-,26+,27-/m0/s1	WALWAYAYWTTWRZ-SFHIZKDYSA-N	372909	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 315	Beta-secretase 2			 71.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372909&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556908	402359842							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739868	CC(C)[C@H]1CN(CCO1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C28H29F2N5O2S/c1-16(2)23-15-35(8-9-37-23)25(36)28-12-24(28)27(3,34-26(32)38-28)19-10-17(4-6-20(19)29)11-21(30)22-7-5-18(13-31)14-33-22/h4-7,10-11,14,16,23-24H,8-9,12,15H2,1-3H3,(H2,32,34)/b21-11-/t23-,24+,27-,28+/m1/s1	ZFNVGDSREKPUGX-IAKCUAKVSA-N	372911	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-2-isopropylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 316	Beta-secretase 2			 33.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372911&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557243	402359844							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739871	CC(C)[C@@H]1CN(CCO1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C28H29F2N5O2S/c1-16(2)23-15-35(8-9-37-23)25(36)28-12-24(28)27(3,34-26(32)38-28)19-10-17(4-6-20(19)29)11-21(30)22-7-5-18(13-31)14-33-22/h4-7,10-11,14,16,23-24H,8-9,12,15H2,1-3H3,(H2,32,34)/b21-11-/t23-,24-,27+,28-/m0/s1	ZFNVGDSREKPUGX-OBOGUXCMSA-N	372912	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((R)-2-isopropylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 317	Beta-secretase 2			 7.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372912&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556657	402359845							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739874	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOC2(CC2)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H25F2N5O2S/c1-25(18-10-16(2-4-19(18)28)11-20(29)21-5-3-17(13-30)14-32-21)22-12-27(22,37-24(31)33-25)23(35)34-8-9-36-26(15-34)6-7-26/h2-5,10-11,14,22H,6-9,12,15H2,1H3,(H2,31,33)/b20-11-/t22-,25+,27-/m0/s1	UTWRSCAMZWMCGR-HHHJTNMUSA-N	372913	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(4-oxa-7-azaspiro[2.5]octane-7-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 318	Beta-secretase 2			 51.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372913&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285418	402359846							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739877	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC2(C1)CCOCC2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C28H27F2N5O2S/c1-26(19-10-17(2-4-20(19)29)11-21(30)22-5-3-18(13-31)14-33-22)23-12-28(23,38-25(32)34-26)24(36)35-15-27(16-35)6-8-37-9-7-27/h2-5,10-11,14,23H,6-9,12,15-16H2,1H3,(H2,32,34)/b21-11-/t23-,26+,28-/m0/s1	LOAMOHNMIZGTEO-TVMKHPBUSA-N	372914	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(4-oxa-7-azaspiro[2.5]octane-7-6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(8-oxa-3-azabicyclo[3.2.1]octane-3-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 319	Beta-secretase 2			 97.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372914&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556917	402359847							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739880	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC2(C1)CCOCC2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C28H27F2N5O2S/c1-26(19-10-17(2-4-20(19)29)11-21(30)22-5-3-18(13-31)14-33-22)23-12-28(23,38-25(32)34-26)24(36)35-15-27(16-35)6-8-37-9-7-27/h2-5,10-11,14,23H,6-9,12,15-16H2,1H3,(H2,32,34)/b21-11-/t23-,26+,28-/m0/s1	LOAMOHNMIZGTEO-TVMKHPBUSA-N	372915	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(7-oxa-2-azaspiro[3.5]nonane-2-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 320	Beta-secretase 2			 39.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372915&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556917	402359848							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739883	C[C@H]1CN(CCO1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H25F2N5O2S/c1-15-14-33(7-8-35-15)23(34)26-11-22(26)25(2,32-24(30)36-26)18-9-16(3-5-19(18)27)10-20(28)21-6-4-17(12-29)13-31-21/h3-6,9-10,13,15,22H,7-8,11,14H2,1-2H3,(H2,30,32)/b20-10-/t15-,22-,25+,26-/m0/s1	VPSXLXIKSSLDME-YRXDLUBPSA-N	372916	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-((S)-2-methylmorpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 321	Beta-secretase 2			 111							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372916&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557180	402359849							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739320	C[C@@H]1CCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C24H23ClF2N4OS/c1-13-7-8-31(13)21(32)24-11-20(24)23(2,30-22(28)33-24)16-9-14(3-5-17(16)26)10-18(27)19-6-4-15(25)12-29-19/h3-6,9-10,12-13,20H,7-8,11H2,1-2H3,(H2,28,30)/b18-10-/t13-,20+,23-,24+/m1/s1	DHQPJSRTYUHTOL-WQBQOYPWSA-N	372716	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((R)-2-methylazetidin-1-yl)methanone::US10246429, Example 120	Beta-secretase 2			 10.8							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372716	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372716&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557112	402359652							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739323	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)NC1CC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C24H21F2N5OS/c1-23(20-10-24(20,33-22(28)31-23)21(32)30-15-4-5-15)16-8-13(2-6-17(16)25)9-18(26)19-7-3-14(11-27)12-29-19/h2-3,6-9,12,15,20H,4-5,10H2,1H3,(H2,28,31)(H,30,32)/b18-9-/t20-,23+,24-/m0/s1	XYHMVQVKHCUFNM-AWTRGSECSA-N	372717	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N-cyclopropyl-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 121	Beta-secretase 2			 164							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372717&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557688	402359653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739326	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC(F)(F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H21F4N5OS/c1-23(20-10-25(20,36-22(31)33-23)21(35)34-7-6-24(28,29)13-34)16-8-14(2-4-17(16)26)9-18(27)19-5-3-15(11-30)12-32-19/h2-5,8-9,12,20H,6-7,10,13H2,1H3,(H2,31,33)/b18-9-/t20-,23+,25-/m0/s1	FQGIAWZPFOIVNT-OMZASBRBSA-N	372718	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,3-difluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 122	Beta-secretase 2			 69.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372718&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557080	402359654							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739329	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C24H21F2N5OS/c1-23(20-11-24(20,33-22(28)30-23)21(32)31-7-2-8-31)16-9-14(3-5-17(16)25)10-18(26)19-6-4-15(12-27)13-29-19/h3-6,9-10,13,20H,2,7-8,11H2,1H3,(H2,28,30)/b18-10-/t20-,23+,24-/m0/s1	HLXYTIWCONMVCO-GQRGEFGTSA-N	372719	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(azetidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 123	Beta-secretase 2			 15.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372719&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524300	402359655							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739332	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H23F2N5O2S/c1-24(21-12-25(21,35-23(29)31-24)22(33)32-6-8-34-9-7-32)17-10-15(2-4-18(17)26)11-19(27)20-5-3-16(13-28)14-30-20/h2-5,10-11,14,21H,6-9,12H2,1H3,(H2,29,31)/b19-11-/t21-,24+,25-/m0/s1	VZHFJCNPAIRJSA-MYMUPAQMSA-N	372720	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 124	Beta-secretase 2			 108							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372720&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	U64	6WNY	126557115	402359656							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739335	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@H](O)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H23F2N5O2S/c1-24(21-10-25(21,35-23(29)31-24)22(34)32-7-6-16(33)13-32)17-8-14(2-4-18(17)26)9-19(27)20-5-3-15(11-28)12-30-20/h2-5,8-9,12,16,21,33H,6-7,10,13H2,1H3,(H2,29,31)/b19-9-/t16-,21-,24+,25-/m0/s1	IBWXJAVCODUFQB-SBPSGRQOSA-N	372721	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-hydroxypyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 125	Beta-secretase 2			 36.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372721	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372721&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557124	402359657							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739338	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H](F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H22F3N5OS/c1-24(21-10-25(21,35-23(30)32-24)22(34)33-7-6-16(26)13-33)17-8-14(2-4-18(17)27)9-19(28)20-5-3-15(11-29)12-31-20/h2-5,8-9,12,16,21H,6-7,10,13H2,1H3,(H2,30,32)/b19-9-/t16-,21+,24-,25+/m1/s1	LDZLINYMNZPQDX-GVZVELPGSA-N	372722	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((R)-3-fluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 126	Beta-secretase 2			 29.9							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372722	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372722&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524406	402359658							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739341	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@H](F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H22F3N5OS/c1-24(21-10-25(21,35-23(30)32-24)22(34)33-7-6-16(26)13-33)17-8-14(2-4-18(17)27)9-19(28)20-5-3-15(11-29)12-31-20/h2-5,8-9,12,16,21H,6-7,10,13H2,1H3,(H2,30,32)/b19-9-/t16-,21-,24+,25-/m0/s1	LDZLINYMNZPQDX-SBPSGRQOSA-N	372723	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-fluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 127	Beta-secretase 2			 51.9							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372723	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372723&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524416	402359659							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739344	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)NC1CCOCC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H25F2N5O2S/c1-25(22-12-26(22,36-24(30)33-25)23(34)32-17-6-8-35-9-7-17)18-10-15(2-4-19(18)27)11-20(28)21-5-3-16(13-29)14-31-21/h2-5,10-11,14,17,22H,6-9,12H2,1H3,(H2,30,33)(H,32,34)/b20-11-/t22-,25+,26-/m0/s1	FMDQBZFEGDOSSX-RTQJJNGSSA-N	372724	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-N-(tetrahydro-2H-pyran-4-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 128	Beta-secretase 2			 89.2							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372724	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372724&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558752	402359660							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739347	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1Cc2ccccc2C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C29H23F2N5OS/c1-28(21-10-17(6-8-22(21)30)11-23(31)24-9-7-18(13-32)14-34-24)25-12-29(25,38-27(33)35-28)26(37)36-15-19-4-2-3-5-20(19)16-36/h2-11,14,25H,12,15-16H2,1H3,(H2,33,35)/b23-11-/t25-,28+,29-/m0/s1	HYFDUAZKGHOXSC-YFPHVNJUSA-N	372725	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(isoindoline-2-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile bis(2,2,2-trifluoroacetate)::US10246429, Example 129	Beta-secretase 2			 31.1							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372725&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524380	402359661							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739350	COC(=O)[C@H]1CCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H25F2N5O3S/c1-26(17-10-15(5-7-18(17)28)11-19(29)20-8-6-16(13-30)14-32-20)22-12-27(22,38-25(31)33-26)24(36)34-9-3-4-21(34)23(35)37-2/h5-8,10-11,14,21-22H,3-4,9,12H2,1-2H3,(H2,31,33)/b19-11-/t21-,22+,26-,27+/m1/s1	MGMSMRUVMOSSHQ-NNQLRQPNSA-N	372726	(R)-methyl 1-((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carbonyl)pyrrolidine-2-carboxylate bis(2,2,2-trifluoroacetate)::US10246429, Example 130	Beta-secretase 2			 121							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372726	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372726&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557485	402359662							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739353	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCN(CC1)c1ccccc1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C31H28F2N6OS/c1-30(23-15-20(7-9-24(23)32)16-25(33)26-10-8-21(18-34)19-36-26)27-17-31(27,41-29(35)37-30)28(40)39-13-11-38(12-14-39)22-5-3-2-4-6-22/h2-10,15-16,19,27H,11-14,17H2,1H3,(H2,35,37)/b25-16-/t27-,30+,31-/m0/s1	DLHIENGTCWBBLF-MMNKXQQRSA-N	372727	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(4-phenylpiperazine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 131	Beta-secretase 2			 15.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372727&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558753	402359663							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739356	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC2CC1CO2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H23F2N5O2S/c1-25(18-6-14(2-4-19(18)27)7-20(28)21-5-3-15(10-29)11-31-21)22-9-26(22,36-24(30)32-25)23(34)33-12-17-8-16(33)13-35-17/h2-7,11,16-17,22H,8-9,12-13H2,1H3,(H2,30,32)/b20-7-/t16?,17?,22-,25+,26-/m0/s1	KJBMIJNRRQQZKO-FHOJGWAWSA-N	372728	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 132	Beta-secretase 2			 75.8							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372728&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557122	402359664							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739359	C[C@@H]1CC[C@@H](C)N1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5OS/c1-15-4-5-16(2)34(15)24(35)27-12-23(27)26(3,33-25(31)36-27)19-10-17(6-8-20(19)28)11-21(29)22-9-7-18(13-30)14-32-22/h6-11,14-16,23H,4-5,12H2,1-3H3,(H2,31,33)/b21-11-/t15-,16-,23+,26-,27+/m1/s1	DKRZVJOGTBMHPK-KHAZCECESA-N	372729	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((2R,5R)-2,5-dimethylpyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 133	Beta-secretase 2			 99.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372729	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372729&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556783	402359665							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739362	CN(C)[C@@H]1CCN(C1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H28F2N6OS/c1-26(19-10-16(4-6-20(19)28)11-21(29)22-7-5-17(13-30)14-32-22)23-12-27(23,37-25(31)33-26)24(36)35-9-8-18(15-35)34(2)3/h4-7,10-11,14,18,23H,8-9,12,15H2,1-3H3,(H2,31,33)/b21-11-/t18-,23+,26-,27+/m1/s1	NXBNDZMYICANRC-MHPWGYBPSA-N	372730	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((R)-3-(dimethylamino)pyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 134	Beta-secretase 2			 800							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372730	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372730&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524644	402359666							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739365	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H]2CCCC[C@H]2C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C30H31F2N5OS/c1-29(22-12-18(6-8-23(22)31)13-24(32)25-9-7-19(15-33)16-35-25)26-14-30(26,39-28(34)36-29)27(38)37-11-10-20-4-2-3-5-21(20)17-37/h6-9,12-13,16,20-21,26H,2-5,10-11,14,17H2,1H3,(H2,34,36)/b24-13-/t20-,21-,26-,29+,30-/m0/s1	OKCROLBQEYZDEH-GVYKSHRCSA-N	372731	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((4aS,8aR)-decahydroisoquinoline-2-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 135	Beta-secretase 2			 1.66							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372731&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557690	402359667							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739368	CC12CC(CC(C)(C)C1)N(C2)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C31H33F2N5OS/c1-28(2)11-20-12-29(3,16-28)17-38(20)26(39)31-13-25(31)30(4,37-27(35)40-31)21-9-18(5-7-22(21)32)10-23(33)24-8-6-19(14-34)15-36-24/h5-10,15,20,25H,11-13,16-17H2,1-4H3,(H2,35,37)/b23-10-/t20?,25-,29?,30+,31-/m0/s1	QKKFONCUTBWQBL-FMPGGSJUSA-N	372732	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octane-6-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 136	Beta-secretase 2			 36.3							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372732&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285454	402359668							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739371	CC1CC(C)CN(C1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C28H29F2N5OS/c1-16-8-17(2)15-35(14-16)25(36)28-11-24(28)27(3,34-26(32)37-28)20-9-18(4-6-21(20)29)10-22(30)23-7-5-19(12-31)13-33-23/h4-7,9-10,13,16-17,24H,8,11,14-15H2,1-3H3,(H2,32,34)/b22-10-/t16?,17?,24-,27+,28-/m0/s1	DPNSZYKLPQSLQS-DBRDEATQSA-N	372733	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,5-dimethylpiperidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 137	Beta-secretase 2			 210							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372733&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557692	402359669							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739374	CC1CCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H25F2N5OS/c1-15-4-3-9-33(15)23(34)26-12-22(26)25(2,32-24(30)35-26)18-10-16(5-7-19(18)27)11-20(28)21-8-6-17(13-29)14-31-21/h5-8,10-11,14-15,22H,3-4,9,12H2,1-2H3,(H2,30,32)/b20-11-/t15?,22-,25+,26-/m0/s1	JXAIFXNHHPOZLG-HYWWUNLHSA-N	372734	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(2-methylpyrrolidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 138	Beta-secretase 2			 92.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372734	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372734&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524754	402359670							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739377	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC(CC1)C(F)(F)F)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H24F5N5OS/c1-25(18-10-15(2-4-19(18)28)11-20(29)21-5-3-16(13-33)14-35-21)22-12-26(22,39-24(34)36-25)23(38)37-8-6-17(7-9-37)27(30,31)32/h2-5,10-11,14,17,22H,6-9,12H2,1H3,(H2,34,36)/b20-11-/t22-,25+,26-/m0/s1	GVHZDKUSTLNXJA-RTQJJNGSSA-N	372735	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(4-(trifluoromethyl)piperidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 139	Beta-secretase 2			 2.57							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372735	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372735&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524317	402359671							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739380	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC(C1)c1ccccc1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C32H29F2N5OS/c1-31(24-14-20(9-11-25(24)33)15-26(34)27-12-10-21(17-35)18-37-27)28-16-32(28,41-30(36)38-31)29(40)39-13-5-8-23(19-39)22-6-3-2-4-7-22/h2-4,6-7,9-12,14-15,18,23,28H,5,8,13,16,19H2,1H3,(H2,36,38)/b26-15-/t23?,28-,31+,32-/m0/s1	OKPCKVKUYLJLOU-RWUQKKDJSA-N	372736	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(3-phenylpiperidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 140	Beta-secretase 2			 13.1							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372736&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556786	402359672							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
740012	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(OC(F)(F)F)cn2)ccc1F	InChI=1S/C22H19F5N4O2S/c1-20(17-9-21(17,18(32)29-2)34-19(28)31-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(10-30-16)33-22(25,26)27/h3-8,10,17H,9H2,1-2H3,(H2,28,31)(H,29,32)/b15-8-/t17-,20+,21-/m0/s1	AMSUFMIKAVJJHZ-NZUJZPRYSA-N	372959	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 364	Beta-secretase 2			 285							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372959&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556918	402359891							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739383	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCN(CC2CC2)CC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C29H30F2N6OS/c1-28(21-12-19(4-6-22(21)30)13-23(31)24-7-5-20(15-32)16-34-24)25-14-29(25,39-27(33)35-28)26(38)37-10-8-36(9-11-37)17-18-2-3-18/h4-7,12-13,16,18,25H,2-3,8-11,14,17H2,1H3,(H2,33,35)/b23-13-/t25-,28+,29-/m0/s1	DNYXGRZKEWSFGX-OIIJDMPMSA-N	372737	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(4-(cyclopropylmethyl)piperazine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 141	Beta-secretase 2			 336							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372737&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523956	402359673							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739386	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCNC(=O)CC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H24F2N6O2S/c1-25(17-10-15(2-4-18(17)27)11-19(28)20-5-3-16(13-29)14-32-20)21-12-26(21,37-24(30)33-25)23(36)34-8-6-22(35)31-7-9-34/h2-5,10-11,14,21H,6-9,12H2,1H3,(H2,30,33)(H,31,35)/b19-11-/t21-,25+,26-/m0/s1	SWIQFRVYNIPNSJ-YTARNQHZSA-N	372738	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(5-oxo-1,4-diazepane-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 142	Beta-secretase 2			 17.3							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372738&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524024	402359674							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739389	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC(C1)C#N)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H24F2N6OS/c1-26(19-9-16(4-6-20(19)28)10-21(29)22-7-5-17(12-30)14-33-22)23-11-27(23,37-25(32)34-26)24(36)35-8-2-3-18(13-31)15-35/h4-7,9-10,14,18,23H,2-3,8,11,15H2,1H3,(H2,32,34)/b21-10-/t18?,23-,26+,27-/m0/s1	VSIIJJHOPUKSIM-CSZIEDIISA-N	372739	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3-cyanopiperidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 143	Beta-secretase 2			 12.7							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372739&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524423	402359675							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739392	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCNC(=O)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H22F2N6O2S/c1-24(20-10-25(20,36-23(29)32-24)22(35)33-7-6-30-21(34)13-33)16-8-14(2-4-17(16)26)9-18(27)19-5-3-15(11-28)12-31-19/h2-5,8-9,12,20H,6-7,10,13H2,1H3,(H2,29,32)(H,30,34)/b18-9-/t20-,24+,25-/m0/s1	XQIRFHXAOHCZDS-LKXBDJSQSA-N	372740	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(3-oxopiperazine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 144	Beta-secretase 2			 28.2							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372740	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372740&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524069	402359676							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739395	CC1CCCN(C1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5OS/c1-16-4-3-9-34(15-16)24(35)27-12-23(27)26(2,33-25(31)36-27)19-10-17(5-7-20(19)28)11-21(29)22-8-6-18(13-30)14-32-22/h5-8,10-11,14,16,23H,3-4,9,12,15H2,1-2H3,(H2,31,33)/b21-11-/t16?,23-,26+,27-/m0/s1	XUGPWMKVJPUDBV-JSOZYDPRSA-N	372741	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(3-methylpiperidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 145	Beta-secretase 2			 17.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372741&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524133	402359677							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739398	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCCC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H25F2N5OS/c1-25(22-13-26(22,35-24(30)32-25)23(34)33-9-3-2-4-10-33)18-11-16(5-7-19(18)27)12-20(28)21-8-6-17(14-29)15-31-21/h5-8,11-12,15,22H,2-4,9-10,13H2,1H3,(H2,30,32)/b20-12-/t22-,25+,26-/m0/s1	SWVMBKBHZPWAQL-VPLUUOPTSA-N	372742	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(piperidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 146	Beta-secretase 2			 25.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372742&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524292	402359678							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739401	CC1CCN(CC1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5OS/c1-16-7-9-34(10-8-16)24(35)27-13-23(27)26(2,33-25(31)36-27)19-11-17(3-5-20(19)28)12-21(29)22-6-4-18(14-30)15-32-22/h3-6,11-12,15-16,23H,7-10,13H2,1-2H3,(H2,31,33)/b21-12-/t23-,26+,27-/m0/s1	OYNSRFMLAUJYHW-MTTZXFIPSA-N	372743	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(4-methylpiperidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 147	Beta-secretase 2			 4.86							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372743	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372743&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524407	402359679							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739404	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(Br)cn2)ccc1F	InChI=1S/C20H17BrF2N4O2S/c1-19(15-7-20(15,17(28)29-2)30-18(24)27-19)11-5-10(3-4-12(11)22)6-13(23)14-8-26-16(21)9-25-14/h3-6,8-9,15H,7H2,1-2H3,(H2,24,27)/b13-6-/t15-,19+,20-/m0/s1	NVFWJNBYTAVRTH-UFEHXVDGSA-N	372744	(1S,5S,6S)-methyl 3-amino-5-(5-((Z)-2-(5-bromopyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 148	Beta-secretase 2			 1030							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372744	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372744&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556792	402359680							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739407	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C20H17ClF2N4O2S/c1-19(15-7-20(15,17(28)29-2)30-18(24)27-19)11-5-10(3-4-12(11)22)6-13(23)14-8-26-16(21)9-25-14/h3-6,8-9,15H,7H2,1-2H3,(H2,24,27)/b13-6-/t15-,19+,20-/m0/s1	QGWRMZGYBUDSPT-UFEHXVDGSA-N	372745	(1S,5S,6S)-methyl 3-amino-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 149	Beta-secretase 2			 206							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372745&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558764	402359681							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739410	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3ncco3)cn2)ccc1F	InChI=1S/C24H21F2N5O4S/c1-23(18-9-24(18,21(32)33-2)36-22(27)31-23)14-7-13(3-4-15(14)25)8-16(26)17-10-30-19(11-29-17)35-12-20-28-5-6-34-20/h3-8,10-11,18H,9,12H2,1-2H3,(H2,27,31)/b16-8-/t18-,23+,24-/m0/s1	NGLDTAOEELXCRA-GWSKSGCMSA-N	372746	(1S,5S,6S)-methyl 3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(oxazol-2-ylmethoxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 150	Beta-secretase 2			 2420							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372746&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557095	402359682							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739413	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C23H21F2N5O2S/c1-4-7-32-19-12-28-17(11-29-19)16(25)9-13-5-6-15(24)14(8-13)22(2)18-10-23(18,20(31)27-3)33-21(26)30-22/h1,5-6,8-9,11-12,18H,7,10H2,2-3H3,(H2,26,30)(H,27,31)/b16-9-/t18-,22+,23-/m0/s1	IOBHOJOKKYDUHV-JLUYBFTRSA-N	372747	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 151	Beta-secretase 2			 396							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372747&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557048	402359683							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739416	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(C)=O)cn2)ccc1F	InChI=1S/C23H23F2N5O3S/c1-12(31)11-33-19-10-28-17(9-29-19)16(25)7-13-4-5-15(24)14(6-13)22(2)18-8-23(18,20(32)27-3)34-21(26)30-22/h4-7,9-10,18H,8,11H2,1-3H3,(H2,26,30)(H,27,32)/b16-7-/t18-,22+,23-/m0/s1	BOEPWVQVRIQDDJ-NKPLGVBDSA-N	372748	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2-oxopropoxy)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 152	Beta-secretase 2			 1510							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372748&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557101	402359684							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739419	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C24H23F2N5O2S/c1-5-8-33-20-13-28-18(12-29-20)17(26)10-14-6-7-16(25)15(9-14)23(2)19-11-24(19,21(32)31(3)4)34-22(27)30-23/h1,6-7,9-10,12-13,19H,8,11H2,2-4H3,(H2,27,30)/b17-10-/t19-,23+,24-/m0/s1	KTPFWOVBDFLYFH-FKSQQWJUSA-N	372749	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 153	Beta-secretase 2			 51.8							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372749	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372749&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557096	402359685							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739422	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3ncco3)cn2)ccc1F	InChI=1S/C25H24F2N6O3S/c1-24(19-10-25(19,22(34)33(2)3)37-23(28)32-24)15-8-14(4-5-16(15)26)9-17(27)18-11-31-20(12-30-18)36-13-21-29-6-7-35-21/h4-9,11-12,19H,10,13H2,1-3H3,(H2,28,32)/b17-9-/t19-,24+,25-/m0/s1	ULOGGRNPZYESEH-BYMCWXSZSA-N	372750	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(oxazol-2-ylmethoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 154	Beta-secretase 2			 45.5							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372750&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557158	402359686							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739425	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C23H22F5N5O2S/c1-21(17-8-22(17,19(34)33(2)3)36-20(29)32-21)13-6-12(4-5-14(13)24)7-15(25)16-9-31-18(10-30-16)35-11-23(26,27)28/h4-7,9-10,17H,8,11H2,1-3H3,(H2,29,32)/b15-7-/t17-,21+,22-/m0/s1	BIPUQNDFGTXMQY-JURDMDRRSA-N	372751	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,2-trifluoroethoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 155	Beta-secretase 2			 82.3							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372751&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558766	402359687							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739428	CC(Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N(C)C)c1ncco1	InChI=1S/C26H26F2N6O3S/c1-14(22-30-7-8-36-22)37-21-13-31-19(12-32-21)18(28)10-15-5-6-17(27)16(9-15)25(2)20-11-26(20,23(35)34(3)4)38-24(29)33-25/h5-10,12-14,20H,11H2,1-4H3,(H2,29,33)/b18-10-/t14?,20-,25+,26-/m0/s1	RMQFIBKMLCGHDU-VVJFDWMOSA-N	372752	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(-1-(oxazol-2-yl)ethoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 156	Beta-secretase 2			 135							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372752&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556817	402359688							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739431	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(Br)cn2)ccc1F	InChI=1S/C21H20BrF2N5OS/c1-20(16-8-21(16,18(30)29(2)3)31-19(25)28-20)12-6-11(4-5-13(12)23)7-14(24)15-9-27-17(22)10-26-15/h4-7,9-10,16H,8H2,1-3H3,(H2,25,28)/b14-7-/t16-,20+,21-/m0/s1	WQIAITOTMUYZNS-ZGRBDRHUSA-N	372753	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 157	Beta-secretase 2			 26.2							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372753&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555093	402359689							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739434	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#N)cn2)ccc1F	InChI=1S/C23H22F2N6O2S/c1-22(18-10-23(18,20(32)31(2)3)34-21(27)30-22)14-8-13(4-5-15(14)24)9-16(25)17-11-29-19(12-28-17)33-7-6-26/h4-5,8-9,11-12,18H,7,10H2,1-3H3,(H2,27,30)/b16-9-/t18-,22+,23-/m0/s1	YRQRZMYRCNYFPN-JLUYBFTRSA-N	372754	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyanomethoxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 158	Beta-secretase 2			 92.7							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372754&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557159	402359690							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739437	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#CC2CC2)ccc1F	InChI=1S/C26H25F2N5OS/c1-25(22-12-26(22,23(34)33(2)3)35-24(29)32-25)18-10-16(7-9-19(18)27)11-20(28)21-14-30-17(13-31-21)8-6-15-4-5-15/h7,9-11,13-15,22H,4-5,12H2,1-3H3,(H2,29,32)/b20-11-/t22-,25+,26-/m0/s1	IILHRPBIZQQPPM-RTQJJNGSSA-N	372755	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyclopropylethynyl)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 159	Beta-secretase 2			 19.6							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372755	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372755&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558768	402359691							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739440	Cc1cc(cnc1\C(F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)C#N	InChI=1S/C26H25F2N5O2S/c1-15-9-17(13-29)14-31-22(15)20(28)11-16-3-4-19(27)18(10-16)25(2)21-12-26(21,36-24(30)32-25)23(34)33-5-7-35-8-6-33/h3-4,9-11,14,21H,5-8,12H2,1-2H3,(H2,30,32)/b20-11-/t21-,25+,26-/m0/s1	YMGFWBCLGQJOEY-JMBIYAIKSA-N	372756	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)-5-methylnicotinonitrile::US10246429, Example 160	Beta-secretase 2			 89.1							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372756&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558767	402359692							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739443	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)(F)C(F)F)cn2)ccc1F	InChI=1S/C23H21F6N5O2S/c1-21(16-7-22(16,19(35)31-2)37-20(30)34-21)12-5-11(3-4-13(12)24)6-14(25)15-8-33-17(9-32-15)36-10-23(28,29)18(26)27/h3-6,8-9,16,18H,7,10H2,1-2H3,(H2,30,34)(H,31,35)/b14-6-/t16-,21+,22-/m0/s1	KUNFXSYLCHZTCZ-COOOTPKDSA-N	372757	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-tetrafluoropropoxy)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 161	Beta-secretase 2			 755							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372757	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372757&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558770	402359693							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739446	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3ncco3)cn2)ccc1F	InChI=1S/C24H22F2N6O3S/c1-23(18-9-24(18,21(33)28-2)36-22(27)32-23)14-7-13(3-4-15(14)25)8-16(26)17-10-31-19(11-30-17)35-12-20-29-5-6-34-20/h3-8,10-11,18H,9,12H2,1-2H3,(H2,27,32)(H,28,33)/b16-8-/t18-,23+,24-/m0/s1	HGNSJVHZUPAHAE-GWSKSGCMSA-N	372759	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(oxazol-2-ylmethoxy)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 162	Beta-secretase 2			 659							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372759&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556828	402359695							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739449	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(Br)cn2)ccc1F	InChI=1S/C20H18BrF2N5OS/c1-19(15-7-20(15,17(29)25-2)30-18(24)28-19)11-5-10(3-4-12(11)22)6-13(23)14-8-27-16(21)9-26-14/h3-6,8-9,15H,7H2,1-2H3,(H2,24,28)(H,25,29)/b13-6-/t15-,19+,20-/m0/s1	LTCQOVSIUPBLAL-UFEHXVDGSA-N	372760	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 163	Beta-secretase 2			 266							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372760	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372760&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556829	402359696							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739452	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#CC)ccc1F	InChI=1S/C23H21F2N5OS/c1-4-5-14-11-29-18(12-28-14)17(25)9-13-6-7-16(24)15(8-13)22(2)19-10-23(19,20(31)27-3)32-21(26)30-22/h6-9,11-12,19H,10H2,1-3H3,(H2,26,30)(H,27,31)/b17-9-/t19-,22+,23-/m0/s1	CMYDYGSOMVRCJR-OZNMDXOXSA-N	372761	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-1-yn-1-yl)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 164	Beta-secretase 2			 229							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372761&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558771	402359697							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739455	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#CC2CC2)ccc1F	InChI=1S/C25H23F2N5OS/c1-24(21-11-25(21,22(33)29-2)34-23(28)32-24)17-9-15(6-8-18(17)26)10-19(27)20-13-30-16(12-31-20)7-5-14-3-4-14/h6,8-10,12-14,21H,3-4,11H2,1-2H3,(H2,28,32)(H,29,33)/b19-10-/t21-,24+,25-/m0/s1	GQGNWPCJBMVMCO-XCZGQCRVSA-N	372762	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyclopropylethynyl)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 165	Beta-secretase 2			 307							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372762	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372762&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556830	402359698							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739458	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#C[Si](C)(C)C)ccc1F	InChI=1S/C25H27F2N5OSSi/c1-24(21-12-25(21,22(33)29-2)34-23(28)32-24)17-10-15(6-7-18(17)26)11-19(27)20-14-30-16(13-31-20)8-9-35(3,4)5/h6-7,10-11,13-14,21H,12H2,1-5H3,(H2,28,32)(H,29,33)/b19-11-/t21-,24+,25-/m0/s1	DVWZMWFBZXHRSX-MYMUPAQMSA-N	372763	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((trimethylsilyl)ethynyl)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4- azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 166	Beta-secretase 2			 1720							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372763	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372763&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			140892426	402359699							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739461	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#C)ccc1F	InChI=1S/C22H19F2N5OS/c1-4-13-10-28-17(11-27-13)16(24)8-12-5-6-15(23)14(7-12)21(2)18-9-22(18,19(30)26-3)31-20(25)29-21/h1,5-8,10-11,18H,9H2,2-3H3,(H2,25,29)(H,26,30)/b16-8-/t18-,21+,22-/m0/s1	MWDTZDZOCXHQIR-ZKMBLFMTSA-N	372764	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-ethynylpyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 167	Beta-secretase 2			 160							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372764	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372764&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557164	402359700							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739464	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cc2)C#N)ccc1F	InChI=1S/C24H22F2N4OS/c1-23(20-12-24(20,21(31)30(2)3)32-22(28)29-23)17-10-15(6-9-18(17)25)11-19(26)16-7-4-14(13-27)5-8-16/h4-11,20H,12H2,1-3H3,(H2,28,29)/b19-11-/t20-,23+,24-/m0/s1	TVYNFQRIKMNFCQ-NNWQNEGFSA-N	372765	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(4-cyanophenyl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 168	Beta-secretase 2			 104							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372765&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557486	402359701							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739467	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C22H20F2N6OS/c1-21(18-8-22(18,19(31)30(2)3)32-20(26)29-21)14-6-12(4-5-15(14)23)7-16(24)17-11-27-13(9-25)10-28-17/h4-7,10-11,18H,8H2,1-3H3,(H2,26,29)/b16-7-/t18-,21+,22-/m0/s1	XZUSTFQBDGMJHQ-DRKXBUJASA-N	372766	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 169	Beta-secretase 2			 17.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372766&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557218	402359702							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739470	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ncc(cn2)C#N)ccc1F	InChI=1S/C22H20F2N6OS/c1-21(17-8-22(17,19(31)30(2)3)32-20(26)29-21)14-6-12(4-5-15(14)23)7-16(24)18-27-10-13(9-25)11-28-18/h4-7,10-11,17H,8H2,1-3H3,(H2,26,29)/b16-7-/t17-,21+,22-/m0/s1	GYWRUGZECHJSKQ-BQLJKHBWSA-N	372767	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyrimidin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 170	Beta-secretase 2			 3.05							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372767&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557216	402359703							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739473	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(nc2)C#N)ccc1F	InChI=1S/C23H21F2N5OS/c1-22(19-10-23(19,20(31)30(2)3)32-21(27)29-22)16-8-13(4-7-17(16)24)9-18(25)14-5-6-15(11-26)28-12-14/h4-9,12,19H,10H2,1-3H3,(H2,27,29)/b18-9-/t19-,22+,23-/m0/s1	FYLGLSCYRURQBA-ZODCYZKFSA-N	372768	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(6-cyanopyridin-3-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 171	Beta-secretase 2			 642							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372768&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558772	402359704							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739476	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cc2F)C#N)ccc1F	InChI=1S/C24H21F3N4OS/c1-23(20-11-24(20,21(32)31(2)3)33-22(29)30-23)16-8-13(5-7-17(16)25)9-18(26)15-6-4-14(12-28)10-19(15)27/h4-10,20H,11H2,1-3H3,(H2,29,30)/b18-9-/t20-,23+,24-/m0/s1	DCOGRKMISVHTKD-AWTRGSECSA-N	372769	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(4-cyano-2-fluorophenyl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 172	Beta-secretase 2			 146							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372769	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372769&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557104	402359705							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739479	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(nc2)C#N)ccc1F	InChI=1S/C22H20F2N6OS/c1-21(17-8-22(17,19(31)30(2)3)32-20(26)29-21)14-6-12(4-5-15(14)23)7-16(24)13-10-27-18(9-25)28-11-13/h4-7,10-11,17H,8H2,1-3H3,(H2,26,29)/b16-7-/t17-,21+,22-/m0/s1	ZSFZZPGBWPNYOJ-BQLJKHBWSA-N	372770	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(2-cyanopyrimidin-5-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 173	Beta-secretase 2			 300							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372770&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557107	402359706							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739482	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(nn2)C#N)ccc1F	InChI=1S/C22H20F2N6OS/c1-21(18-10-22(18,19(31)30(2)3)32-20(26)27-21)14-8-12(4-6-15(14)23)9-16(24)17-7-5-13(11-25)28-29-17/h4-9,18H,10H2,1-3H3,(H2,26,27)/b16-9-/t18-,21+,22-/m0/s1	JNKQNDIJCRUXGC-LLYJTOGPSA-N	372771	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(6-cyanopyridazin-3-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 174	Beta-secretase 2			 406							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372771&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556831	402359707							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739485	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H19ClF2N4OS/c1-20(17-9-21(17,18(29)26-2)30-19(25)28-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(22)10-27-16/h3-8,10,17H,9H2,1-2H3,(H2,25,28)(H,26,29)/b15-8-/t17-,20+,21-/m0/s1	GQYPSNWOTOYMPJ-NZUJZPRYSA-N	372772	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 175	Beta-secretase 2			 36.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372772	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372772&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285446	402359708							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739488	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)cnc1F	InChI=1S/C20H17ClF2N4O2S/c1-19(15-7-20(15,17(28)29-2)30-18(24)27-19)12-5-10(8-26-16(12)23)6-13(22)14-4-3-11(21)9-25-14/h3-6,8-9,15H,7H2,1-2H3,(H2,24,27)/b13-6-/t15-,19+,20-/m0/s1	UJRFPPBPWKJZEJ-UFEHXVDGSA-N	372773	(1S,5S,6S)-methyl 3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 176	Beta-secretase 2			 214							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372773&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285485	402359709							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739491	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(\F)c2ccc(Cl)cn2)cnc1F	InChI=1S/C20H17ClF2N4O2S/c1-19(15-7-20(15,17(28)29-2)30-18(24)27-19)12-5-10(8-26-16(12)23)6-13(22)14-4-3-11(21)9-25-14/h3-6,8-9,15H,7H2,1-2H3,(H2,24,27)/b13-6+/t15-,19+,20-/m0/s1	UJRFPPBPWKJZEJ-WNWFVDBQSA-N	372774	(1S,5S,6S)-methyl 3-amino-5-(5-((E)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 177	Beta-secretase 2			 2904							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372774&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556832	402359710							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739494	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)cnc1F	InChI=1S/C21H20ClF2N5OS/c1-20(16-8-21(16,18(30)29(2)3)31-19(25)28-20)13-6-11(9-27-17(13)24)7-14(23)15-5-4-12(22)10-26-15/h4-7,9-10,16H,8H2,1-3H3,(H2,25,28)/b14-7-/t16-,20+,21-/m0/s1	FWGZNBROHVPNGW-ZGRBDRHUSA-N	372775	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 178	Beta-secretase 2			 5.74							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372775&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524087	402359711							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739497	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(\F)c2ccc(Cl)cn2)cnc1F	InChI=1S/C21H20ClF2N5OS/c1-20(16-8-21(16,18(30)29(2)3)31-19(25)28-20)13-6-11(9-27-17(13)24)7-14(23)15-5-4-12(22)10-26-15/h4-7,9-10,16H,8H2,1-3H3,(H2,25,28)/b14-7+/t16-,20+,21-/m0/s1	FWGZNBROHVPNGW-XGPYDDKASA-N	372776	(1S,5S,6S)-3-amino-5-(5-((E)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 179	Beta-secretase 2			 41.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372776&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557712	402359712							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739500	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C22H20F2N6OS/c1-21(17-8-22(17,19(31)30(2)3)32-20(26)29-21)14-6-13(11-28-18(14)24)7-15(23)16-5-4-12(9-25)10-27-16/h4-7,10-11,17H,8H2,1-3H3,(H2,26,29)/b15-7-/t17-,21+,22-/m0/s1	WKEOTYZSPKOUPH-JURDMDRRSA-N	372777	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluoropyridin-3-yl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 180	Beta-secretase 2			 23.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372777&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285447	402359713							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739503	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H](F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C24H21F3N6OS/c1-23(19-8-24(19,35-22(29)32-23)21(34)33-5-4-15(25)12-33)16-6-14(11-31-20(16)27)7-17(26)18-3-2-13(9-28)10-30-18/h2-3,6-7,10-11,15,19H,4-5,8,12H2,1H3,(H2,29,32)/b17-7-/t15-,19+,23-,24+/m1/s1	PKBZVGSMKHULBV-KCUSIJHYSA-N	372778	6-((Z)-2-(5-((1S,5S,6S)-3-amino-1-((R)-3-fluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 181	Beta-secretase 2			 33.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372778&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523954	402359714							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739506	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@H](F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C24H21F3N6OS/c1-23(19-8-24(19,35-22(29)32-23)21(34)33-5-4-15(25)12-33)16-6-14(11-31-20(16)27)7-17(26)18-3-2-13(9-28)10-30-18/h2-3,6-7,10-11,15,19H,4-5,8,12H2,1H3,(H2,29,32)/b17-7-/t15-,19-,23+,24-/m0/s1	PKBZVGSMKHULBV-RDOSCTEVSA-N	372779	6-((Z)-2-(5-((1S,5S,6S)-3-amino-1-((S)-3-fluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 182	Beta-secretase 2			 45.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372779&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523979	402359715							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739509	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C24H22F2N6O2S/c1-23(19-10-24(19,35-22(28)31-23)21(33)32-4-6-34-7-5-32)16-8-15(13-30-20(16)26)9-17(25)18-3-2-14(11-27)12-29-18/h2-3,8-9,12-13,19H,4-7,10H2,1H3,(H2,28,31)/b17-9-/t19-,23+,24-/m0/s1	SHKIDCBHVZAMLK-ZEHMKQDJSA-N	372780	6-((Z)-2-(5-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 183	Beta-secretase 2			 241							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372780	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372780&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524421	402359716							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739511	COc1ncc(\C=C(/F)c2ccc(cn2)C#N)cc1[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H](F)C1	InChI=1S/C25H24F2N6O2S/c1-24(20-9-25(20,36-23(29)32-24)22(34)33-6-5-16(26)13-33)17-7-15(12-31-21(17)35-2)8-18(27)19-4-3-14(10-28)11-30-19/h3-4,7-8,11-12,16,20H,5-6,9,13H2,1-2H3,(H2,29,32)/b18-8-/t16-,20+,24-,25+/m1/s1	MPJRIKYRYVEEKB-YCQLKXSLSA-N	372781	6-((Z)-2-(5-((1S,5S,6S)-3-amino-1-((R)-3-fluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-methoxypyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 184	Beta-secretase 2			 340							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372781&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524398	402359717							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739514	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C(\F)=C\c1ccc(Cl)cn1	InChI=1S/C22H21ClF2N4OS/c1-21(18-10-22(18,19(30)29(2)3)31-20(26)28-21)15-8-12(4-7-16(15)24)17(25)9-14-6-5-13(23)11-27-14/h4-9,11,18H,10H2,1-3H3,(H2,26,28)/b17-9-/t18-,21+,22-/m0/s1	RWLBYZPNYFDYTA-WBRHMWNYSA-N	372782	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-1-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 185	Beta-secretase 2			 76.4							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372782&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557517	402359718							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739517	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C(\F)=C\c1ccc(cc1)C#N	InChI=1S/C24H22F2N4OS/c1-23(20-12-24(20,21(31)30(2)3)32-22(28)29-23)17-11-16(8-9-18(17)25)19(26)10-14-4-6-15(13-27)7-5-14/h4-11,20H,12H2,1-3H3,(H2,28,29)/b19-10-/t20-,23+,24-/m0/s1	HZZFSMGJPIYQAR-KHTKAAKSSA-N	372783	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(4-cyanophenyl)-1-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 186::US10246429, Example 221	Beta-secretase 2			 302							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557184	402359719							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739520	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C24H22F2N6O2S/c1-23(20-10-24(20,35-22(28)31-23)21(33)32-4-6-34-7-5-32)16-8-14(2-3-17(16)25)9-18(26)19-13-29-15(11-27)12-30-19/h2-3,8-9,12-13,20H,4-7,10H2,1H3,(H2,28,31)/b18-9-/t20-,23+,24-/m0/s1	KSLJUUCKMWVFIH-AWTRGSECSA-N	372784	5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile::US10246429, Example 200	Beta-secretase 2			 118							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372784&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524400	402359720							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739523	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCCC1)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C25H24F2N6OS/c1-24(21-11-25(21,35-23(29)32-24)22(34)33-7-3-2-4-8-33)17-9-15(5-6-18(17)26)10-19(27)20-14-30-16(12-28)13-31-20/h5-6,9-10,13-14,21H,2-4,7-8,11H2,1H3,(H2,29,32)/b19-10-/t21-,24+,25-/m0/s1	MOQWVFFJPGWFAC-XCZGQCRVSA-N	372785	5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(piperidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile::US10246429, Example 201	Beta-secretase 2			 74.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372785&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524296	402359721							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739526	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@H](F)C1)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C24H21F3N6OS/c1-23(20-8-24(20,35-22(29)32-23)21(34)33-5-4-14(25)12-33)16-6-13(2-3-17(16)26)7-18(27)19-11-30-15(9-28)10-31-19/h2-3,6-7,10-11,14,20H,4-5,8,12H2,1H3,(H2,29,32)/b18-7-/t14-,20-,23+,24-/m0/s1	KNQASGMYRYSFDQ-XASYZPPQSA-N	372786	5-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-fluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile::US10246429, Example 202	Beta-secretase 2			 40.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372786&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524044	402359722							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739529	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H](F)C1)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C24H21F3N6OS/c1-23(20-8-24(20,35-22(29)32-23)21(34)33-5-4-14(25)12-33)16-6-13(2-3-17(16)26)7-18(27)19-11-30-15(9-28)10-31-19/h2-3,6-7,10-11,14,20H,4-5,8,12H2,1H3,(H2,29,32)/b18-7-/t14-,20+,23-,24+/m1/s1	KNQASGMYRYSFDQ-QHKJJCSPSA-N	372787	5-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((R)-3-fluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile::US10246429, Example 203	Beta-secretase 2			 45.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372787&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524190	402359723							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739532	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC1)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C24H22F2N6OS/c1-23(20-10-24(20,34-22(28)31-23)21(33)32-6-2-3-7-32)16-8-14(4-5-17(16)25)9-18(26)19-13-29-15(11-27)12-30-19/h4-5,8-9,12-13,20H,2-3,6-7,10H2,1H3,(H2,28,31)/b18-9-/t20-,23+,24-/m0/s1	FYUJBUIYANSXFK-AWTRGSECSA-N	372788	5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(pyrrolidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile::US10246429, Example 204	Beta-secretase 2			 48.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372788&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524428	402359724							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739535	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#C)ccc1F	InChI=1S/C23H21F2N5OS/c1-5-14-11-28-18(12-27-14)17(25)9-13-6-7-16(24)15(8-13)22(2)19-10-23(19,20(31)30(3)4)32-21(26)29-22/h1,6-9,11-12,19H,10H2,2-4H3,(H2,26,29)/b17-9-/t19-,22+,23-/m0/s1	DEPPEMUWPWWMIN-OZNMDXOXSA-N	372789	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-ethynylpyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 205	Beta-secretase 2			 10.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372789&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557541	402359725							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739538	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)I)ccc1F	InChI=1S/C17H18F2IN3OS/c1-16(10-6-9(7-13(19)20)4-5-11(10)18)12-8-17(12,14(24)23(2)3)25-15(21)22-16/h4-7,12H,8H2,1-3H3,(H2,21,22)/b13-7+/t12-,16+,17-/m0/s1	VQGXNUSUDVEUAJ-GRWZZNAFSA-N	372790	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((E)-2-fluoro-2-iodovinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 206	Beta-secretase 2			 8.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372790	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372790&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557543	402359726							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739541	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)C#Cc2ccccc2)ccc1F	InChI=1S/C25H23F2N3OS/c1-24(21-15-25(21,22(31)30(2)3)32-23(28)29-24)19-14-17(10-12-20(19)27)13-18(26)11-9-16-7-5-4-6-8-16/h4-8,10,12-14,21H,15H2,1-3H3,(H2,28,29)/b18-13-/t21-,24+,25-/m0/s1	UMPCXDSOAGHNKA-OSDHJJHOSA-N	372791	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-4-phenylbut-1-en-3-yn-1-yl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 207	Beta-secretase 2			 18.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372791&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524756	402359727							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739544	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C/F)ccc1F	InChI=1S/C17H19F2N3OS/c1-16(11-8-10(6-7-18)4-5-12(11)19)13-9-17(13,14(23)22(2)3)24-15(20)21-16/h4-8,13H,9H2,1-3H3,(H2,20,21)/b7-6-/t13-,16+,17-/m0/s1	DHLXPVPRSWFPDM-YQIRRWJHSA-N	372792	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluorovinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 208	Beta-secretase 2			 117							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372792	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372792&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558776	402359728							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739547	CC#C\C(F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N(C)C	InChI=1S/C20H21F2N3OS/c1-5-6-13(21)9-12-7-8-15(22)14(10-12)19(2)16-11-20(16,17(26)25(3)4)27-18(23)24-19/h7-10,16H,11H2,1-4H3,(H2,23,24)/b13-9-/t16-,19+,20-/m0/s1	OUAKIYBBTXXOGH-ASIXZSLSSA-N	372793	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoropent-1-en-3-yn-1-yl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 209	Beta-secretase 2			 10.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372793	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372793&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285412	402359729							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739550	COCCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N(C)C	InChI=1S/C24H27F2N5O3S/c1-23(19-11-24(19,21(32)31(2)3)35-22(27)30-23)15-9-14(5-6-16(15)25)10-17(26)18-12-29-20(13-28-18)34-8-7-33-4/h5-6,9-10,12-13,19H,7-8,11H2,1-4H3,(H2,27,30)/b17-10-/t19-,23+,24-/m0/s1	OMFMXSKYXSWDPM-FKSQQWJUSA-N	372794	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2-methoxyethoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 210	Beta-secretase 2			 72.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372794&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557178	402359730							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739553	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3CC3)cn2)ccc1F	InChI=1S/C25H27F2N5O2S/c1-24(20-10-25(20,22(33)32(2)3)35-23(28)31-24)16-8-15(6-7-17(16)26)9-18(27)19-11-30-21(12-29-19)34-13-14-4-5-14/h6-9,11-12,14,20H,4-5,10,13H2,1-3H3,(H2,28,31)/b18-9-/t20-,24+,25-/m0/s1	GCMPFMSBMAWRTM-LKXBDJSQSA-N	372795	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyclopropylmethoxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 211	Beta-secretase 2			 44.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372795	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372795&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557715	402359731							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739556	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3COC3)cn2)ccc1F	InChI=1S/C25H27F2N5O3S/c1-24(20-8-25(20,22(33)32(2)3)36-23(28)31-24)16-6-14(4-5-17(16)26)7-18(27)19-9-30-21(10-29-19)35-13-15-11-34-12-15/h4-7,9-10,15,20H,8,11-13H2,1-3H3,(H2,28,31)/b18-7-/t20-,24+,25-/m0/s1	BLLHHCMXCSOLGG-WXGYDDDCSA-N	372796	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(oxetan-3-ylmethoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 212	Beta-secretase 2			 77.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372796&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557114	402359732							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739559	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)F)cn2)ccc1F	InChI=1S/C23H23F4N5O2S/c1-22(17-8-23(17,20(33)32(2)3)35-21(28)31-22)13-6-12(4-5-14(13)24)7-15(25)16-9-30-19(10-29-16)34-11-18(26)27/h4-7,9-10,17-18H,8,11H2,1-3H3,(H2,28,31)/b15-7-/t17-,22+,23-/m0/s1	CQWTVZFUHYUMAN-QDQBMDPYSA-N	372797	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(2,2-difluoroethoxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 213	Beta-secretase 2			 65.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372797	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372797&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557560	402359733							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739562	COC[C@H](C)Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N(C)C	InChI=1S/C25H29F2N5O3S/c1-14(13-34-5)35-21-12-29-19(11-30-21)18(27)9-15-6-7-17(26)16(8-15)24(2)20-10-25(20,22(33)32(3)4)36-23(28)31-24/h6-9,11-12,14,20H,10,13H2,1-5H3,(H2,28,31)/b18-9-/t14-,20-,24+,25-/m0/s1	LXYGGJLBNREGCZ-QSRUKNEYSA-N	372798	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(((S)-1-methoxypropan-2-yl)oxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 214	Beta-secretase 2			 72.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372798&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556838	402359734							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739565	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3CC3(F)F)cn2)ccc1F	InChI=1S/C25H25F4N5O2S/c1-23(19-9-24(19,21(35)34(2)3)37-22(30)33-23)15-6-13(4-5-16(15)26)7-17(27)18-10-32-20(11-31-18)36-12-14-8-25(14,28)29/h4-7,10-11,14,19H,8-9,12H2,1-3H3,(H2,30,33)/b17-7-/t14?,19-,23+,24-/m0/s1	DQBBZPXWGYZNAK-PKEWXJKTSA-N	372799	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-((2,2-difluorocyclopropyl)methoxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 215	Beta-secretase 2			 51.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372799&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557586	402359735							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739886	CC(C)[C@@H]1COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C28H29F2N5O2S/c1-16(2)23-15-37-9-8-35(23)25(36)28-12-24(28)27(3,34-26(32)38-28)19-10-17(4-6-20(19)29)11-21(30)22-7-5-18(13-31)14-33-22/h4-7,10-11,14,16,23-24H,8-9,12,15H2,1-3H3,(H2,32,34)/b21-11-/t23-,24-,27+,28-/m0/s1	MQSSLRBZFVPDKD-OBOGUXCMSA-N	372917	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((R)-3-isopropylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 322	Beta-secretase 2			 30.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372917&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558793	402359850							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739889	C[C@H]1CN(C[C@H](C)O1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-15-13-34(14-16(2)36-15)24(35)27-10-23(27)26(3,33-25(31)37-27)19-8-17(4-6-20(19)28)9-21(29)22-7-5-18(11-30)12-32-22/h4-9,12,15-16,23H,10,13-14H2,1-3H3,(H2,31,33)/b21-9-/t15-,16-,23-,26+,27-/m0/s1	PAQFQFYQFMQIAU-CJFKRUMWSA-N	372918	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((2S,6S)-2,6-dimethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 323	Beta-secretase 2			 192							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372918&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557635	402359851							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739892	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC(F)(F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H23F4N5OS/c1-24(17-9-15(3-5-18(17)27)10-19(28)20-6-4-16(12-31)13-33-20)21-11-26(21,37-23(32)34-24)22(36)35-8-2-7-25(29,30)14-35/h3-6,9-10,13,21H,2,7-8,11,14H2,1H3,(H2,32,34)/b19-10-/t21-,24+,26-/m0/s1	PERQGBHIWDTVOX-RJLYDSCCSA-N	372919	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,3-difluoropiperidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 324	Beta-secretase 2			 19.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372919&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524028	402359852							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739895	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC(F)(F)CC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H23F4N5OS/c1-24(17-10-15(2-4-18(17)27)11-19(28)20-5-3-16(13-31)14-33-20)21-12-26(21,37-23(32)34-24)22(36)35-8-6-25(29,30)7-9-35/h2-5,10-11,14,21H,6-9,12H2,1H3,(H2,32,34)/b19-11-/t21-,24+,26-/m0/s1	OOLWSXXSHVERMM-HAJRAODLSA-N	372920	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(4,4-difluoropiperidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 325	Beta-secretase 2			 89.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372920&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524436	402359853							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739898	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC(F)CC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H24F3N5OS/c1-25(22-12-26(22,36-24(31)33-25)23(35)34-8-6-17(27)7-9-34)18-10-15(2-4-19(18)28)11-20(29)21-5-3-16(13-30)14-32-21/h2-5,10-11,14,17,22H,6-9,12H2,1H3,(H2,31,33)/b20-11-/t22-,25+,26-/m0/s1	MXXHXJBBOINVTH-RTQJJNGSSA-N	372921	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(4-fluoropiperidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 326	Beta-secretase 2			 45.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372921&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524420	402359854							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739901	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC2(CCO2)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H25F2N5O2S/c1-25(18-10-16(2-4-19(18)28)11-20(29)21-5-3-17(13-30)14-32-21)22-12-27(22,37-24(31)33-25)23(35)34-8-6-26(15-34)7-9-36-26/h2-5,10-11,14,22H,6-9,12,15H2,1H3,(H2,31,33)/b20-11-/t22-,25+,26?,27-/m0/s1	VGLJZZSQBIDHRM-KRQHHWEJSA-N	372922	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(1-oxa-6-azaspiro[3.4]octane-6-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 327	Beta-secretase 2			 28.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372922&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524356	402359855							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739904	COC[C@H]1COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O3S/c1-26(19-9-16(3-5-20(19)28)10-21(29)22-6-4-17(12-30)13-32-22)23-11-27(23,38-25(31)33-26)24(35)34-7-8-37-15-18(34)14-36-2/h3-6,9-10,13,18,23H,7-8,11,14-15H2,1-2H3,(H2,31,33)/b21-10-/t18-,23-,26+,27-/m0/s1	SCKAYIQTMXSRCI-UPDZBHERSA-N	372923	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-(methoxymethyl)morpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 328	Beta-secretase 2			 85.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372923&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557761	402359856							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739907	C[C@H]1CN([C@@H](C)CO1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-15-14-36-16(2)13-34(15)24(35)27-10-23(27)26(3,33-25(31)37-27)19-8-17(4-6-20(19)28)9-21(29)22-7-5-18(11-30)12-32-22/h4-9,12,15-16,23H,10,13-14H2,1-3H3,(H2,31,33)/b21-9-/t15-,16-,23-,26+,27-/m0/s1	FDAMZZMLRCCRII-CJFKRUMWSA-N	372924	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((2S,5S)-2,5-dimethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 329	Beta-secretase 2			 124							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372924&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557638	402359857							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739910	C[C@@H]1CN([C@H](C)CO1)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-15-14-36-16(2)13-34(15)24(35)27-10-23(27)26(3,33-25(31)37-27)19-8-17(4-6-20(19)28)9-21(29)22-7-5-18(11-30)12-32-22/h4-9,12,15-16,23H,10,13-14H2,1-3H3,(H2,31,33)/b21-9-/t15-,16-,23+,26-,27+/m1/s1	FDAMZZMLRCCRII-LFDWGKEUSA-N	372925	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((2R,5R)-2,5-dimethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 330	Beta-secretase 2			 239							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372925&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557201	402359858							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739913	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC11CCC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C28H27F2N5O2S/c1-26(19-11-17(3-5-20(19)29)12-21(30)22-6-4-18(14-31)15-33-22)23-13-28(23,38-25(32)34-26)24(36)35-9-10-37-16-27(35)7-2-8-27/h3-6,11-12,15,23H,2,7-10,13,16H2,1H3,(H2,32,34)/b21-12-/t23-,26+,28-/m0/s1	CUZPHKRHXXBSJB-VBQVKNGPSA-N	372926	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(8-oxa-5-azaspiro[3.5]nonane-5-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 331	Beta-secretase 2			 61.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372926&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557246	402359859							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739916	CC1(C)COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-25(2)15-36-9-8-34(25)23(35)27-12-22(27)26(3,33-24(31)37-27)18-10-16(4-6-19(18)28)11-20(29)21-7-5-17(13-30)14-32-21/h4-7,10-11,14,22H,8-9,12,15H2,1-3H3,(H2,31,33)/b20-11-/t22-,26+,27-/m0/s1	WBFTZCDXILITBE-MRRORNCHSA-N	372927	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,3-dimethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 332	Beta-secretase 2			 109							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372927&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557207	402359860							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739919	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@@H](O)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H23F2N5O2S/c1-24(21-10-25(21,35-23(29)31-24)22(34)32-7-6-16(33)13-32)17-8-14(2-4-18(17)26)9-19(27)20-5-3-15(11-28)12-30-20/h2-5,8-9,12,16,21,33H,6-7,10,13H2,1H3,(H2,29,31)/b19-9-/t16-,21+,24-,25+/m1/s1	IBWXJAVCODUFQB-GVZVELPGSA-N	372928	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((R)-3-hydroxypyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 333	Beta-secretase 2			 53.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372928&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557774	402359861							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739922	CC[C@H]1COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-3-18-15-36-9-8-34(18)24(35)27-12-23(27)26(2,33-25(31)37-27)19-10-16(4-6-20(19)28)11-21(29)22-7-5-17(13-30)14-32-22/h4-7,10-11,14,18,23H,3,8-9,12,15H2,1-2H3,(H2,31,33)/b21-11-/t18-,23-,26+,27-/m0/s1	JOCUJUMMDGCOKI-FPGHDCOESA-N	372929	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-ethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 334::US10246429, Example 335	Beta-secretase 2			 146							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372929&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557245	402359862							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739925	CC[C@H]1COCCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C27H27F2N5O2S/c1-3-18-15-36-9-8-34(18)24(35)27-12-23(27)26(2,33-25(31)37-27)19-10-16(4-6-20(19)28)11-21(29)22-7-5-17(13-30)14-32-22/h4-7,10-11,14,18,23H,3,8-9,12,15H2,1-2H3,(H2,31,33)/b21-11-/t18-,23-,26+,27-/m0/s1	JOCUJUMMDGCOKI-FPGHDCOESA-N	372929	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((S)-3-ethylmorpholine-4-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 334::US10246429, Example 335	Beta-secretase 2			 186							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372929&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557245	402359862							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739928	C[C@H]1[C@H](O)CCN1C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C26H25F2N5O2S/c1-14-21(34)7-8-33(14)23(35)26-11-22(26)25(2,32-24(30)36-26)17-9-15(3-5-18(17)27)10-19(28)20-6-4-16(12-29)13-31-20/h3-6,9-10,13-14,21-22,34H,7-8,11H2,1-2H3,(H2,30,32)/b19-10-/t14-,21+,22-,25+,26-/m0/s1	DKJQDSFQSMLEKX-VRGNFYOHSA-N	372931	6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((2S,3R)-3-hydroxy-2-methylpyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 336	Beta-secretase 2			 55.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372931&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126554894	402359863							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739931	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC1c1ccccc1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C31H27F2N5OS/c1-30(22-14-19(9-11-23(22)32)15-24(33)25-12-10-20(17-34)18-36-25)27-16-31(27,40-29(35)37-30)28(39)38-13-5-8-26(38)21-6-3-2-4-7-21/h2-4,6-7,9-12,14-15,18,26-27H,5,8,13,16H2,1H3,(H2,35,37)/b24-15-/t26?,27-,30+,31-/m0/s1	XBDAZKPOFSVCMB-MUSFUJQMSA-N	372932	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(2-phenylpyrrolidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 337	Beta-secretase 2			 46.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372932&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557203	402359864							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739934	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F	InChI=1S/C24H23BrF2N4O2S/c1-23(20-12-24(20,34-22(28)30-23)21(32)31-6-8-33-9-7-31)16-10-14(2-4-17(16)26)11-18(27)19-5-3-15(25)13-29-19/h2-5,10-11,13,20H,6-9,12H2,1H3,(H2,28,30)/b18-11-/t20-,23+,24-/m0/s1	OBVOAGZBBSFJLL-JXOCDECTSA-N	372933	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 338	Beta-secretase 2			 5.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372933&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524419	402359865							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739937	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccccn2)ccc1F	InChI=1S/C24H24F2N4O2S/c1-23(16-12-15(5-6-17(16)25)13-18(26)19-4-2-3-7-28-19)20-14-24(20,33-22(27)29-23)21(31)30-8-10-32-11-9-30/h2-7,12-13,20H,8-11,14H2,1H3,(H2,27,29)/b18-13-/t20-,23+,24-/m0/s1	KYBPFSKXJNYBMX-HBQSFAJUSA-N	372934	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(pyridin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 339	Beta-secretase 2			 165							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372934&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555292	402359866							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739940	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(cn2)C2COC2)ccc1F	InChI=1S/C27H28F2N4O3S/c1-26(23-12-27(23,37-25(30)32-26)24(34)33-6-8-35-9-7-33)19-10-16(2-4-20(19)28)11-21(29)22-5-3-17(13-31-22)18-14-36-15-18/h2-5,10-11,13,18,23H,6-9,12,14-15H2,1H3,(H2,30,32)/b21-11-/t23-,26+,27-/m0/s1	VDCFTGCAQPOQIL-SNZBUMTISA-N	372935	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(oxetan-3-yl)pyridin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 340	Beta-secretase 2			 3210							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372935&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555291	402359867							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739943	COC(CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)OC	InChI=1S/C25H25F2N5O3S/c1-24(20-10-25(20,36-23(29)32-24)22(33)31-13-21(34-2)35-3)16-8-14(4-6-17(16)26)9-18(27)19-7-5-15(11-28)12-30-19/h4-9,12,20-21H,10,13H2,1-3H3,(H2,29,32)(H,31,33)/b18-9-/t20-,24+,25-/m0/s1	OPXWNGUVFVQSQT-LKXBDJSQSA-N	372936	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N-(2,2-dimethoxyethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 341	Beta-secretase 2			 24.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372936&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556909	402359868							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739946	CC1COC(=N1)[C@]12C[C@H]1[C@](C)(N=C(NC(=O)OC(C)(C)C)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C29H29F2N5O3S/c1-16-15-38-24(34-16)29-12-23(29)28(5,36-25(40-29)35-26(37)39-27(2,3)4)19-10-17(6-8-20(19)30)11-21(31)22-9-7-18(13-32)14-33-22/h6-11,14,16,23H,12,15H2,1-5H3,(H,35,36,37)/b21-11-/t16?,23-,28+,29-/m0/s1	IVGMNGMRLRZYRJ-NXTSBJMESA-N	372937	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(4-methyl-4,5-dihydrooxazol-2-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 342	Beta-secretase 2			 700							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372937&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557614	402359869							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739949	C[C@@H]1CN=C(O1)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C24H21F2N5OS/c1-13-11-30-21(32-13)24-9-20(24)23(2,31-22(28)33-24)16-7-14(3-5-17(16)25)8-18(26)19-6-4-15(10-27)12-29-19/h3-8,12-13,20H,9,11H2,1-2H3,(H2,28,31)/b18-8-/t13-,20+,23-,24+/m1/s1	AZSNIEUGFZDGJF-COSKVJGZSA-N	372938	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-((R)-5-methyl-4,5-dihydrooxazol-2-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 343	Beta-secretase 2			 692							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372938&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557772	402359870							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739952	Cc1cnc(o1)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C24H19F2N5OS/c1-13-11-30-21(32-13)24-9-20(24)23(2,31-22(28)33-24)16-7-14(3-5-17(16)25)8-18(26)19-6-4-15(10-27)12-29-19/h3-8,11-12,20H,9H2,1-2H3,(H2,28,31)/b18-8-/t20-,23+,24-/m0/s1	OHAWVJXKTIRSLX-XQYXPFIPSA-N	372939	6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(5-methyloxazol-2-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 344	Beta-secretase 2			 180							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372939&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558786	402359871							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739955	Cc1cnc(o1)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C25H21F2N5O2S/c1-4-7-33-21-13-29-19(12-30-21)18(27)9-15-5-6-17(26)16(8-15)24(3)20-10-25(20,35-23(28)32-24)22-31-11-14(2)34-22/h1,5-6,8-9,11-13,20H,7,10H2,2-3H3,(H2,28,32)/b18-9-/t20-,24+,25-/m0/s1	ZXWFRIXSIVPVAX-LKXBDJSQSA-N	372940	(1S,5S,6S)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-1-(5-methyloxazol-2-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 345	Beta-secretase 2			 520							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372940&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557757	402359872							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739958	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(cn2)N2CCOC2=O)ccc1F	InChI=1S/C26H26F2N6O4S/c1-25(20-12-26(20,39-23(29)32-25)22(35)33-4-7-37-8-5-33)16-10-15(2-3-17(16)27)11-18(28)19-13-31-21(14-30-19)34-6-9-38-24(34)36/h2-3,10-11,13-14,20H,4-9,12H2,1H3,(H2,29,32)/b18-11-/t20-,25+,26-/m0/s1	XAUDAOHQPVNTFC-JXGREVLNSA-N	372941	3-(5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazin-2-yl)oxazolidin-2-one::US10246429, Example 346	Beta-secretase 2			 942							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372941&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285426	402359873							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739961	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(\F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C25H23F2N5O2S/c1-24(21-12-25(21,35-23(29)31-24)22(33)32-6-8-34-9-7-32)17-10-15(2-4-18(17)26)11-19(27)20-5-3-16(13-28)14-30-20/h2-5,10-11,14,21H,6-9,12H2,1H3,(H2,29,31)/b19-11+/t21-,24+,25-/m0/s1	VZHFJCNPAIRJSA-VBJXDNJYSA-N	372942	6-((E)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 347	Beta-secretase 2			 165							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372942&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285381	402359874							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739964	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(cn2)C#C)ccc1F	InChI=1S/C26H24F2N4O2S/c1-3-16-5-7-21(30-15-16)20(28)13-17-4-6-19(27)18(12-17)25(2)22-14-26(22,35-24(29)31-25)23(33)32-8-10-34-11-9-32/h1,4-7,12-13,15,22H,8-11,14H2,2H3,(H2,29,31)/b20-13-/t22-,25+,26-/m0/s1	YMLLRGGALBYXNZ-YOFOPLKZSA-N	372943	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-ethynylpyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 348	Beta-secretase 2			 97.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372943&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523875	402359875							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739967	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(cn2)C#C[Si](C)(C)C)ccc1F	InChI=1S/C28H31F2N5O2SSi/c1-27(24-15-28(24,38-26(31)34-27)25(36)35-8-10-37-11-9-35)20-13-18(5-6-21(20)29)14-22(30)23-17-32-19(16-33-23)7-12-39(2,3)4/h5-6,13-14,16-17,24H,8-11,15H2,1-4H3,(H2,31,34)/b22-14-/t24-,27+,28-/m0/s1	LTVVZLLWAAKSCF-KCFGBKGMSA-N	372944	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((trimethylsilyl)ethynyl)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 349	Beta-secretase 2			 253							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372944&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			140892454	402359876							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739970	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(cn2)C#C)ccc1F	InChI=1S/C25H23F2N5O2S/c1-3-16-13-30-20(14-29-16)19(27)11-15-4-5-18(26)17(10-15)24(2)21-12-25(21,35-23(28)31-24)22(33)32-6-8-34-9-7-32/h1,4-5,10-11,13-14,21H,6-9,12H2,2H3,(H2,28,31)/b19-11-/t21-,24+,25-/m0/s1	XMJNYUHJPBOYJK-MYMUPAQMSA-N	372945	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-ethynylpyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 350	Beta-secretase 2			 46.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372945&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524016	402359877							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739973	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(cn2)N2CCC2)ccc1F	InChI=1S/C26H28F2N6O2S/c1-25(21-13-26(21,37-24(29)32-25)23(35)34-7-9-36-10-8-34)17-11-16(3-4-18(17)27)12-19(28)20-14-31-22(15-30-20)33-5-2-6-33/h3-4,11-12,14-15,21H,2,5-10,13H2,1H3,(H2,29,32)/b19-12-/t21-,25+,26-/m0/s1	VXIVEWZJXLWYDM-QBIJIEJISA-N	372946	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(azetidin-1-yl)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 351	Beta-secretase 2			 1560							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372946&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524201	402359878							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739976	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C20H18ClF2N5OS/c1-19(15-7-20(15,17(29)25-2)30-18(24)28-19)11-5-10(3-4-12(11)22)6-13(23)14-8-27-16(21)9-26-14/h3-6,8-9,15H,7H2,1-2H3,(H2,24,28)(H,25,29)/b13-6-/t15-,19+,20-/m0/s1	MOPFMIRYALKMHX-UFEHXVDGSA-N	372947	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 352	Beta-secretase 2			 29.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372947&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557650	402359879							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739979	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(cn2)C#C[Si](C)(C)C)ccc1F	InChI=1S/C29H32F2N4O2SSi/c1-28(25-17-29(25,38-27(32)34-28)26(36)35-10-12-37-13-11-35)21-15-20(5-7-22(21)30)16-23(31)24-8-6-19(18-33-24)9-14-39(2,3)4/h5-8,15-16,18,25H,10-13,17H2,1-4H3,(H2,32,34)/b23-16-/t25-,28+,29-/m0/s1	PSFDQHPCBBDQRC-LQEROJACSA-N	372948	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((trimethylsilyl)ethynyl)pyridin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 354	Beta-secretase 2			 412							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372948&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			140892517	402359880							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739982	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2cnc(cn2)C#CC2CC2)ccc1F	InChI=1S/C28H27F2N5O2S/c1-27(24-14-28(24,38-26(31)34-27)25(36)35-8-10-37-11-9-35)20-12-18(5-7-21(20)29)13-22(30)23-16-32-19(15-33-23)6-4-17-2-3-17/h5,7,12-13,15-17,24H,2-3,8-11,14H2,1H3,(H2,31,34)/b22-13-/t24-,27+,28-/m0/s1	QPHDKCXJJHMQBS-ABWVXTMBSA-N	372949	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyclopropylethynyl)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 353	Beta-secretase 2			 145							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372949&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557257	402359881							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739985	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F	InChI=1S/C21H19BrF2N4OS/c1-20(17-9-21(17,18(29)26-2)30-19(25)28-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(22)10-27-16/h3-8,10,17H,9H2,1-2H3,(H2,25,28)(H,26,29)/b15-8-/t17-,20+,21-/m0/s1	ARWXOUCKDGGJPN-NZUJZPRYSA-N	372950	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 355	Beta-secretase 2			 69.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372950&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558813	402359882							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739988	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(\F)c2ccc(Br)cn2)ccc1F	InChI=1S/C21H19BrF2N4OS/c1-20(17-9-21(17,18(29)26-2)30-19(25)28-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(22)10-27-16/h3-8,10,17H,9H2,1-2H3,(H2,25,28)(H,26,29)/b15-8+/t17-,20+,21-/m0/s1	ARWXOUCKDGGJPN-RWKOOILESA-N	372951	(1S,5S,6S)-3-amino-5-(5-((E)-2-(5-bromopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 356	Beta-secretase 2			 137							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372951&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285391	402359883							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739991	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(cn2)C#CC2CC2)ccc1F	InChI=1S/C29H28F2N4O2S/c1-28(25-16-29(25,38-27(32)34-28)26(36)35-10-12-37-13-11-35)21-14-20(6-8-22(21)30)15-23(31)24-9-7-19(17-33-24)5-4-18-2-3-18/h6-9,14-15,17-18,25H,2-3,10-13,16H2,1H3,(H2,32,34)/b23-15-/t25-,28+,29-/m0/s1	JIIYCKTXUFSTGT-LQJKTITMSA-N	372952	((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyclopropylethynyl)pyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 357	Beta-secretase 2			 430							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372952&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557219	402359884							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739994	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#CC2CC2)ccc1F	InChI=1S/C26H24F2N4OS/c1-25(22-13-26(22,23(33)30-2)34-24(29)32-25)18-11-17(7-9-19(18)27)12-20(28)21-10-8-16(14-31-21)6-5-15-3-4-15/h7-12,14-15,22H,3-4,13H2,1-2H3,(H2,29,32)(H,30,33)/b20-12-/t22-,25+,26-/m0/s1	SAMIPRMEGBQPDH-VPLUUOPTSA-N	372953	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(cyclopropylethynyl)pyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 358	Beta-secretase 2			 415							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372953&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285443	402359885							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739997	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#CC(C)(C)C)ccc1F	InChI=1S/C27H28F2N4OS/c1-25(2,3)11-10-16-7-9-21(32-15-16)20(29)13-17-6-8-19(28)18(12-17)26(4)22-14-27(22,23(34)31-5)35-24(30)33-26/h6-9,12-13,15,22H,14H2,1-5H3,(H2,30,33)(H,31,34)/b20-13-/t22-,26+,27-/m0/s1	QTBFVIGGAWNUPI-FYHGBWIOSA-N	372954	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(3,3-dimethylbut-1-yn-1-yl)pyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 359	Beta-secretase 2			 794							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372954&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524648	402359886							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
740000	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#CC2(C)COC2)ccc1F	InChI=1S/C27H26F2N4O2S/c1-25(14-35-15-25)9-8-16-5-7-21(32-13-16)20(29)11-17-4-6-19(28)18(10-17)26(2)22-12-27(22,23(34)31-3)36-24(30)33-26/h4-7,10-11,13,22H,12,14-15H2,1-3H3,(H2,30,33)(H,31,34)/b20-11-/t22-,26+,27-/m0/s1	XJFWCACPWJOVNV-MRRORNCHSA-N	372955	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((3-methyloxetan-3-yl)ethynyl)pyridin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 360	Beta-secretase 2			 756							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372955&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285488	402359887							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
740003	CCCC#Cc1ccc(nc1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)NC	InChI=1S/C26H26F2N4OS/c1-4-5-6-7-16-9-11-21(31-15-16)20(28)13-17-8-10-19(27)18(12-17)25(2)22-14-26(22,23(33)30-3)34-24(29)32-25/h8-13,15,22H,4-5,14H2,1-3H3,(H2,29,32)(H,30,33)/b20-13-/t22-,25+,26-/m0/s1	HLRCNUQGDVKCKX-YOFOPLKZSA-N	372956	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(pent-1-yn-1-yl)pyridin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 361	Beta-secretase 2			 490							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372956&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285390	402359888							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
740006	CNC(=O)[C@@]12C[C@@H]1[C@@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ncc(cn2)C#CCO)ccc1F	InChI=1S/C23H21F2N5O2S/c1-22(18-10-23(18,20(32)27-2)33-21(26)30-22)15-8-13(5-6-16(15)24)9-17(25)19-28-11-14(12-29-19)4-3-7-31/h5-6,8-9,11-12,18,31H,7,10H2,1-2H3,(H2,26,30)(H,27,32)/b17-9-/t18-,22+,23-/m1/s1	RYLDWCICPMVKKK-MQZOVGEHSA-N	372957	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(3-hydroxyprop-1-yn-1-yl)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 362	Beta-secretase 2			 365							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372957&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			145713211	402359889							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
740009	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#CCF)ccc1F	InChI=1S/C23H20F3N5OS/c1-22(19-10-23(19,20(32)28-2)33-21(27)31-22)15-8-13(5-6-16(15)25)9-17(26)18-12-29-14(11-30-18)4-3-7-24/h5-6,8-9,11-12,19H,7,10H2,1-2H3,(H2,27,31)(H,28,32)/b17-9-/t19-,22+,23-/m0/s1	ZBASATBLVGHIOQ-OZNMDXOXSA-N	372958	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(3-fluoroprop-1-yn-1-yl)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 363	Beta-secretase 2			 152							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372958&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285433	402359890							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733156	CN1C(=N)N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4ccc(Cl)cn4)cc23)S1(=O)=O	InChI=1S/C19H20ClN5O4S/c1-19-13-9-12(23-17(26)14-5-3-11(20)10-22-14)4-6-15(13)29-8-7-16(19)30(27,28)25(2)18(21)24-19/h3-6,9-10,16H,7-8H2,1-2H3,(H2,21,24)(H,23,26)/t16-,19-/m1/s1	HJYXEYFGGRHBEN-VQIMIIECSA-N	370621	US10238743, Example 1	Beta-secretase 2		 65.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370621	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370621&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264427	402357603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733158	CN1C(=N)N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4ccccn4)cc23)S1(=O)=O	InChI=1S/C19H21N5O4S/c1-19-13-11-12(22-17(25)14-5-3-4-9-21-14)6-7-15(13)28-10-8-16(19)29(26,27)24(2)18(20)23-19/h3-7,9,11,16H,8,10H2,1-2H3,(H2,20,23)(H,22,25)/t16-,19-/m1/s1	NQDVPEIIZBFNNR-VQIMIIECSA-N	370622	US10238743, Example 2	Beta-secretase 2		 279								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370622	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370622&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264117	402357604							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733160	CN1C(=N)N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4nc(C)oc4C)cc23)S1(=O)=O	InChI=1S/C19H23N5O5S/c1-10-16(21-11(2)29-10)17(25)22-12-5-6-14-13(9-12)19(3)15(7-8-28-14)30(26,27)24(4)18(20)23-19/h5-6,9,15H,7-8H2,1-4H3,(H2,20,23)(H,22,25)/t15-,19-/m1/s1	QYUMRXCZKZOLNX-DNVCBOLYSA-N	370623	US10238743, Example 3	Beta-secretase 2		 384								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370623	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370623&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264053	402357605							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733162	COCC(=O)Nc1ccc2OCC[C@@H]3[C@](C)(NC(=N)N(C)S3(=O)=O)c2c1	InChI=1S/C16H22N4O5S/c1-16-11-8-10(18-14(21)9-24-3)4-5-12(11)25-7-6-13(16)26(22,23)20(2)15(17)19-16/h4-5,8,13H,6-7,9H2,1-3H3,(H2,17,19)(H,18,21)/t13-,16-/m1/s1	RNPGXUVFWIIHMF-CZUORRHYSA-N	370626	US10238743, Example 4	Beta-secretase 2		 890								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370626&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264052	402357607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733164	CN1C(=N)N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)S1(=O)=O	InChI=1S/C20H20N6O4S/c1-20-14-9-13(24-18(27)15-5-3-12(10-21)11-23-15)4-6-16(14)30-8-7-17(20)31(28,29)26(2)19(22)25-20/h3-6,9,11,17H,7-8H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20-/m1/s1	WHPBHJQRLDCBOO-YLJYHZDGSA-N	370627	US10238743, Example 5	Beta-secretase 2		 303								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370627&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264059	402357608							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733166	CN1C(=N)N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4ccc(OCC#C)cn4)cc23)S1(=O)=O	InChI=1S/C22H23N5O5S/c1-4-10-31-15-6-7-17(24-13-15)20(28)25-14-5-8-18-16(12-14)22(2)19(9-11-32-18)33(29,30)27(3)21(23)26-22/h1,5-8,12-13,19H,9-11H2,2-3H3,(H2,23,26)(H,25,28)/t19-,22-/m1/s1	SLBFSZHXENDKID-DENIHFKCSA-N	370628	US10238743, Example 6	Beta-secretase 2		 995								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370628&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264060	402357609							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733168	CN1C(=N)N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4ccc(F)cn4)cc23)S1(=O)=O	InChI=1S/C19H20FN5O4S/c1-19-13-9-12(23-17(26)14-5-3-11(20)10-22-14)4-6-15(13)29-8-7-16(19)30(27,28)25(2)18(21)24-19/h3-6,9-10,16H,7-8H2,1-2H3,(H2,21,24)(H,23,26)/t16-,19-/m1/s1	KKURNFJVRFPQSR-VQIMIIECSA-N	370630	US10238743, Example 7	Beta-secretase 2		 159								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370630	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370630&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264094	402357610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733170	CN1C(=N)N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4ncc(F)cc4C)cc23)S1(=O)=O	InChI=1S/C20H22FN5O4S/c1-11-8-12(21)10-23-17(11)18(27)24-13-4-5-15-14(9-13)20(2)16(6-7-30-15)31(28,29)26(3)19(22)25-20/h4-5,8-10,16H,6-7H2,1-3H3,(H2,22,25)(H,24,27)/t16-,20-/m1/s1	IUMSXOBNIPLCAF-OXQOHEQNSA-N	370632	US10238743, Example 8	Beta-secretase 2		 86.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370632&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264095	402357612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733172	COc1cnc(cn1)C(=O)Nc1ccc2OCC[C@@H]3[C@](C)(NC(=N)N(C)S3(=O)=O)c2c1	InChI=1S/C19H22N6O5S/c1-19-12-8-11(23-17(26)13-9-22-16(29-3)10-21-13)4-5-14(12)30-7-6-15(19)31(27,28)25(2)18(20)24-19/h4-5,8-10,15H,6-7H2,1-3H3,(H2,20,24)(H,23,26)/t15-,19-/m1/s1	DOCKLMLUDPVBSF-DNVCBOLYSA-N	370633	US10238743, Example 9	Beta-secretase 2		 5613								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370633	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370633&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264500	402357613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733174	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccccn4)cc23)S1(=O)=O	InChI=1S/C19H21N5O4S/c1-19-13-11-12(22-17(25)14-5-3-4-9-21-14)6-7-15(13)28-10-8-16(19)29(26,27)24(2)18(20)23-19/h3-7,9,11,16H,8,10H2,1-2H3,(H2,20,23)(H,22,25)/t16-,19+/m0/s1	NQDVPEIIZBFNNR-QFBILLFUSA-N	370634	US10238743, Example 10	Beta-secretase 2		 15.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370634	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370634&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264054	402357614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733176	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ncc(Cl)cc4Cl)cc23)S1(=O)=O	InChI=1S/C19H19Cl2N5O4S/c1-19-12-8-11(24-17(27)16-13(21)7-10(20)9-23-16)3-4-14(12)30-6-5-15(19)31(28,29)26(2)18(22)25-19/h3-4,7-9,15H,5-6H2,1-2H3,(H2,22,25)(H,24,27)/t15-,19+/m0/s1	MQGUDCZSNZTAGD-HNAYVOBHSA-N	370635	US10238743, Example 11	Beta-secretase 2		 2.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370635	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370635&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264099	402357615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733178	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccc(OC(F)F)cn4)cc23)S1(=O)=O	InChI=1S/C20H21F2N5O5S/c1-20-13-9-11(25-17(28)14-5-4-12(10-24-14)32-18(21)22)3-6-15(13)31-8-7-16(20)33(29,30)27(2)19(23)26-20/h3-6,9-10,16,18H,7-8H2,1-2H3,(H2,23,26)(H,25,28)/t16-,20+/m0/s1	AOVOIBGZHGBEKJ-OXJNMPFZSA-N	370636	US10238743, Example 12	Beta-secretase 2		 58.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370636	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370636&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264051	402357616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733180	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ncc(Cl)cc4F)cc23)S1(=O)=O	InChI=1S/C19H19ClFN5O4S/c1-19-12-8-11(24-17(27)16-13(21)7-10(20)9-23-16)3-4-14(12)30-6-5-15(19)31(28,29)26(2)18(22)25-19/h3-4,7-9,15H,5-6H2,1-2H3,(H2,22,25)(H,24,27)/t15-,19+/m0/s1	JDSBPYYVHOZZTK-HNAYVOBHSA-N	370637	US10238743, Example 13	Beta-secretase 2		 4.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370637	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370637&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264055	402357617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733182	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccc(F)cn4)cc23)S1(=O)=O	InChI=1S/C19H20FN5O4S/c1-19-13-9-12(23-17(26)14-5-3-11(20)10-22-14)4-6-15(13)29-8-7-16(19)30(27,28)25(2)18(21)24-19/h3-6,9-10,16H,7-8H2,1-2H3,(H2,21,24)(H,23,26)/t16-,19+/m0/s1	KKURNFJVRFPQSR-QFBILLFUSA-N	370638	US10238743, Example 14	Beta-secretase 2		 6.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370638	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370638&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264096	402357618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733184	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ncc(F)cc4F)cc23)S1(=O)=O	InChI=1S/C19H19F2N5O4S/c1-19-12-8-11(24-17(27)16-13(21)7-10(20)9-23-16)3-4-14(12)30-6-5-15(19)31(28,29)26(2)18(22)25-19/h3-4,7-9,15H,5-6H2,1-2H3,(H2,22,25)(H,24,27)/t15-,19+/m0/s1	QXHMHKYXJWWEGI-HNAYVOBHSA-N	370639	US10238743, Example 15	Beta-secretase 2		 6.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370639	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370639&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264097	402357619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733186	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)S1(=O)=O	InChI=1S/C20H20N6O4S/c1-20-14-9-13(24-18(27)15-5-3-12(10-21)11-23-15)4-6-16(14)30-8-7-17(20)31(28,29)26(2)19(22)25-20/h3-6,9,11,17H,7-8H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20+/m0/s1	WHPBHJQRLDCBOO-FXAWDEMLSA-N	370640	US10238743, Example 16	Beta-secretase 2		 14.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370640	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370640&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264098	402357620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733188	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccc(C)cn4)cc23)S1(=O)=O	InChI=1S/C20H23N5O4S/c1-12-4-6-15(22-11-12)18(26)23-13-5-7-16-14(10-13)20(2)17(8-9-29-16)30(27,28)25(3)19(21)24-20/h4-7,10-11,17H,8-9H2,1-3H3,(H2,21,24)(H,23,26)/t17-,20+/m0/s1	SXJQMNQJLJONJL-FXAWDEMLSA-N	370641	US10238743, Example 17	Beta-secretase 2		 16.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370641	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370641&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264154	402357621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733190	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccc(cn4)C(F)(F)F)cc23)S1(=O)=O	InChI=1S/C20H20F3N5O4S/c1-19-13-9-12(26-17(29)14-5-3-11(10-25-14)20(21,22)23)4-6-15(13)32-8-7-16(19)33(30,31)28(2)18(24)27-19/h3-6,9-10,16H,7-8H2,1-2H3,(H2,24,27)(H,26,29)/t16-,19+/m0/s1	TZDOKTGXMRFADW-QFBILLFUSA-N	370642	US10238743, Example 18	Beta-secretase 2		 79.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370642	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370642&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264073	402357622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733192	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccc(OC(F)(F)F)cn4)cc23)S1(=O)=O	InChI=1S/C20H20F3N5O5S/c1-19-13-9-11(26-17(29)14-5-4-12(10-25-14)33-20(21,22)23)3-6-15(13)32-8-7-16(19)34(30,31)28(2)18(24)27-19/h3-6,9-10,16H,7-8H2,1-2H3,(H2,24,27)(H,26,29)/t16-,19+/m0/s1	RUFRNSXADNDLRS-QFBILLFUSA-N	370643	US10238743, Example 19	Beta-secretase 2		 104								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370643&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264075	402357623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733194	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ncc(cc4Cl)C(F)(F)F)cc23)S1(=O)=O	InChI=1S/C20H19ClF3N5O4S/c1-19-12-8-11(27-17(30)16-13(21)7-10(9-26-16)20(22,23)24)3-4-14(12)33-6-5-15(19)34(31,32)29(2)18(25)28-19/h3-4,7-9,15H,5-6H2,1-2H3,(H2,25,28)(H,27,30)/t15-,19+/m0/s1	JRIDJYOHMNMXJY-HNAYVOBHSA-N	370644	US10238743, Example 20	Beta-secretase 2		 36.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370644	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370644&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264069	402357624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733196	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ccc(C)cn4)cc23)S1(=O)=O	InChI=1S/C21H25N5O3S/c1-13-7-10-17(23-12-13)19(27)24-15-9-8-14-5-4-6-18-21(2,16(14)11-15)25-20(22)26(3)30(18,28)29/h7-12,18H,4-6H2,1-3H3,(H2,22,25)(H,24,27)/t18-,21+/m0/s1	XTSBKSPMWSFRNG-GHTZIAJQSA-N	370645	US10238743, Example 21	Beta-secretase 2		 34.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370645	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370645&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264057	402357625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733198	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ccc(OC(F)F)cn4)cc23)S1(=O)=O	InChI=1S/C21H23F2N5O4S/c1-21-15-10-13(26-18(29)16-9-8-14(11-25-16)32-19(22)23)7-6-12(15)4-3-5-17(21)33(30,31)28(2)20(24)27-21/h6-11,17,19H,3-5H2,1-2H3,(H2,24,27)(H,26,29)/t17-,21+/m0/s1	MGJBRXXHCGQXNA-LAUBAEHRSA-N	370646	US10238743, Example 22	Beta-secretase 2		 90.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370646	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370646&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264058	402357626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733200	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ccc(Cl)cn4)cc23)S1(=O)=O	InChI=1S/C20H22ClN5O3S/c1-20-15-10-14(24-18(27)16-9-7-13(21)11-23-16)8-6-12(15)4-3-5-17(20)30(28,29)26(2)19(22)25-20/h6-11,17H,3-5H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20+/m0/s1	IMPHIXJRCFZJFF-FXAWDEMLSA-N	370647	US10238743, Example 23	Beta-secretase 2		 7.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370647	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370647&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264088	402357627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733202	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4cnc(C)cn4)cc23)S1(=O)=O	InChI=1S/C20H24N6O3S/c1-12-10-23-16(11-22-12)18(27)24-14-8-7-13-5-4-6-17-20(2,15(13)9-14)25-19(21)26(3)30(17,28)29/h7-11,17H,4-6H2,1-3H3,(H2,21,25)(H,24,27)/t17-,20+/m0/s1	WVGQBKGRCZGLLS-FXAWDEMLSA-N	370648	US10238743, Example 24	Beta-secretase 2		 251								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370648	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370648&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264090	402357628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733204	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ncc(Cl)cc4F)cc23)S1(=O)=O	InChI=1S/C20H21ClFN5O3S/c1-20-14-9-13(25-18(28)17-15(22)8-12(21)10-24-17)7-6-11(14)4-3-5-16(20)31(29,30)27(2)19(23)26-20/h6-10,16H,3-5H2,1-2H3,(H2,23,26)(H,25,28)/t16-,20+/m0/s1	JQMOARZXLBJMRV-OXJNMPFZSA-N	370649	US10238743, Example 25	Beta-secretase 2		 5.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370649	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370649&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264091	402357629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733206	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ncc(F)cc4F)cc23)S1(=O)=O	InChI=1S/C20H21F2N5O3S/c1-20-14-9-13(25-18(28)17-15(22)8-12(21)10-24-17)7-6-11(14)4-3-5-16(20)31(29,30)27(2)19(23)26-20/h6-10,16H,3-5H2,1-2H3,(H2,23,26)(H,25,28)/t16-,20+/m0/s1	FLSPKWHZMHOXQA-OXJNMPFZSA-N	370650	US10238743, Example 26	Beta-secretase 2		 10.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370650	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370650&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264189	402357630							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733208	COc1cc(Br)cnc1C(=O)Nc1ccc2CCC[C@H]3[C@](C)(NC(=N)N(C)S3(=O)=O)c2c1	InChI=1S/C21H24BrN5O4S/c1-21-15-10-14(25-19(28)18-16(31-3)9-13(22)11-24-18)8-7-12(15)5-4-6-17(21)32(29,30)27(2)20(23)26-21/h7-11,17H,4-6H2,1-3H3,(H2,23,26)(H,25,28)/t17-,21+/m0/s1	ORCOAINGXGNJSU-LAUBAEHRSA-N	370651	US10238743, Example 27	Beta-secretase 2		 10.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370651	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370651&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			130365605	402357631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733210	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ccc(F)cn4)cc23)S1(=O)=O	InChI=1S/C20H22FN5O3S/c1-20-15-10-14(24-18(27)16-9-7-13(21)11-23-16)8-6-12(15)4-3-5-17(20)30(28,29)26(2)19(22)25-20/h6-11,17H,3-5H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20+/m0/s1	CYYGFSQYPWRMCV-FXAWDEMLSA-N	370653	US10238743, Example 28	Beta-secretase 2		 7.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370653	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370653&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264187	402357633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733212	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ccc(OC(F)(F)F)cn4)cc23)S1(=O)=O	InChI=1S/C21H22F3N5O4S/c1-20-15-10-13(27-18(30)16-9-8-14(11-26-16)33-21(22,23)24)7-6-12(15)4-3-5-17(20)34(31,32)29(2)19(25)28-20/h6-11,17H,3-5H2,1-2H3,(H2,25,28)(H,27,30)/t17-,20+/m0/s1	ISKUNNVBERQAHK-FXAWDEMLSA-N	370654	US10238743, Example 29	Beta-secretase 2		 144								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370654	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370654&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			130384043	402357634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733214	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ncc(cc4Cl)C(F)(F)F)cc23)S1(=O)=O	InChI=1S/C21H21ClF3N5O3S/c1-20-14-9-13(28-18(31)17-15(22)8-12(10-27-17)21(23,24)25)7-6-11(14)4-3-5-16(20)34(32,33)30(2)19(26)29-20/h6-10,16H,3-5H2,1-2H3,(H2,26,29)(H,28,31)/t16-,20+/m0/s1	UPCFMTSTZHVCAO-OXJNMPFZSA-N	370655	US10238743, Example 30	Beta-secretase 2		 82.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370655	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370655&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264079	402357635							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733216	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ncc(F)cc4C)cc23)S1(=O)=O	InChI=1S/C21H24FN5O3S/c1-12-9-14(22)11-24-18(12)19(28)25-15-8-7-13-5-4-6-17-21(2,16(13)10-15)26-20(23)27(3)31(17,29)30/h7-11,17H,4-6H2,1-3H3,(H2,23,26)(H,25,28)/t17-,21+/m0/s1	RBDWHBDFBVIGPN-LAUBAEHRSA-N	370656	US10238743, Example 31	Beta-secretase 2		 10.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370656	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370656&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264160	402357636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733218	COc1cnc(C(=O)Nc2ccc3CCC[C@H]4[C@](C)(NC(=N)N(C)S4(=O)=O)c3c2)c(C)c1	InChI=1S/C22H27N5O4S/c1-13-10-16(31-4)12-24-19(13)20(28)25-15-9-8-14-6-5-7-18-22(2,17(14)11-15)26-21(23)27(3)32(18,29)30/h8-12,18H,5-7H2,1-4H3,(H2,23,26)(H,25,28)/t18-,22+/m0/s1	BQPGVTWONMKTNH-PGRDOPGGSA-N	370657	US10238743, Example 32	Beta-secretase 2		 34.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370657	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370657&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264078	402357637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733220	COc1cnc(C(=O)Nc2ccc3CCC[C@H]4[C@](C)(NC(=N)N(C)S4(=O)=O)c3c2)c(C)n1	InChI=1S/C21H26N6O4S/c1-12-18(23-11-17(24-12)31-4)19(28)25-14-9-8-13-6-5-7-16-21(2,15(13)10-14)26-20(22)27(3)32(16,29)30/h8-11,16H,5-7H2,1-4H3,(H2,22,26)(H,25,28)/t16-,21+/m0/s1	PFMZYCZDLWXHEQ-HRAATJIYSA-N	370658	US10238743, Example 33	Beta-secretase 2		 86.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370658	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370658&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264084	402357638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733222	COc1cnc(cn1)C(=O)Nc1ccc2CCC[C@H]3[C@](C)(NC(=N)N(C)S3(=O)=O)c2c1	InChI=1S/C20H24N6O4S/c1-20-14-9-13(24-18(27)15-10-23-17(30-3)11-22-15)8-7-12(14)5-4-6-16(20)31(28,29)26(2)19(21)25-20/h7-11,16H,4-6H2,1-3H3,(H2,21,25)(H,24,27)/t16-,20+/m0/s1	UZHDOSYNYLBRFI-OXJNMPFZSA-N	370659	US10238743, Example 34	Beta-secretase 2		 52.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370659&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264085	402357639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733224	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ncc(cc4C)C#N)cc23)S1(=O)=O	InChI=1S/C22H24N6O3S/c1-13-9-14(11-23)12-25-19(13)20(29)26-16-8-7-15-5-4-6-18-22(2,17(15)10-16)27-21(24)28(3)32(18,30)31/h7-10,12,18H,4-6H2,1-3H3,(H2,24,27)(H,26,29)/t18-,22+/m0/s1	BMECTRKCNNRLOE-PGRDOPGGSA-N	370660	US10238743, Example 35	Beta-secretase 2		 10.00								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370660&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264082	402357640							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733226	CN1C(=N)N[C@@]2(C)[C@H](CCCc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)S1(=O)=O	InChI=1S/C21H22N6O3S/c1-21-16-10-15(25-19(28)17-9-6-13(11-22)12-24-17)8-7-14(16)4-3-5-18(21)31(29,30)27(2)20(23)26-21/h6-10,12,18H,3-5H2,1-2H3,(H2,23,26)(H,25,28)/t18-,21+/m0/s1	DXOCMNBLELQBRX-GHTZIAJQSA-N	370661	US10238743, Example 36	Beta-secretase 2		 25.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370661	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370661&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264076	402357641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733228	CN1C(=N)N[C@@]2(C)[C@@H](CCCc3ccc(NC(=O)c4ccc(F)cn4)cc23)S1(=O)=O	InChI=1S/C20H22FN5O3S/c1-20-15-10-14(24-18(27)16-9-7-13(21)11-23-16)8-6-12(15)4-3-5-17(20)30(28,29)26(2)19(22)25-20/h6-11,17H,3-5H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20-/m1/s1	CYYGFSQYPWRMCV-YLJYHZDGSA-N	370662	US10238743, Example 37	Beta-secretase 2		 96.0								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370662&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264077	402357642							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733230	CN1C(=N)N[C@@]2(C)[C@@H](CCCc3ccc(NC(=O)c4ccc(OC(F)F)cn4)cc23)S1(=O)=O	InChI=1S/C21H23F2N5O4S/c1-21-15-10-13(26-18(29)16-9-8-14(11-25-16)32-19(22)23)7-6-12(15)4-3-5-17(21)33(30,31)28(2)20(24)27-21/h6-11,17,19H,3-5H2,1-2H3,(H2,24,27)(H,26,29)/t17-,21-/m1/s1	MGJBRXXHCGQXNA-DYESRHJHSA-N	370663	US10238743, Example 38	Beta-secretase 2		 857								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370663	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370663&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264081	402357643							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733232	CN1C(=N)N[C@@]2(C)[C@@H](CCCc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)S1(=O)=O	InChI=1S/C21H22N6O3S/c1-21-16-10-15(25-19(28)17-9-6-13(11-22)12-24-17)8-7-14(16)4-3-5-18(21)31(29,30)27(2)20(23)26-21/h6-10,12,18H,3-5H2,1-2H3,(H2,23,26)(H,25,28)/t18-,21-/m1/s1	DXOCMNBLELQBRX-WIYYLYMNSA-N	370664	US10238743, Example 39	Beta-secretase 2		 315								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370664	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370664&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264080	402357644							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733234	CN1C(=N)N[C@@]2(C)[C@@H](CCCc3ccc(NC(=O)c4cnc(C)cn4)cc23)S1(=O)=O	InChI=1S/C20H24N6O3S/c1-12-10-23-16(11-22-12)18(27)24-14-8-7-13-5-4-6-17-20(2,15(13)9-14)25-19(21)26(3)30(17,28)29/h7-11,17H,4-6H2,1-3H3,(H2,21,25)(H,24,27)/t17-,20-/m1/s1	WVGQBKGRCZGLLS-YLJYHZDGSA-N	370665	US10238743, Example 40	Beta-secretase 2		 2714								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370665	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370665&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264083	402357645							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733236	COc1cnc2c(Nc3ccc4OCC[C@H]5[C@](C)(NC(=N)N(C)S5(=O)=O)c4c3)nccc2n1	InChI=1S/C21H23N7O4S/c1-21-13-10-12(25-19-18-14(6-8-23-19)26-17(31-3)11-24-18)4-5-15(13)32-9-7-16(21)33(29,30)28(2)20(22)27-21/h4-6,8,10-11,16H,7,9H2,1-3H3,(H2,22,27)(H,23,25)/t16-,21+/m0/s1	LHWUGHDECXWGMF-HRAATJIYSA-N	370666	US10238743, Example 41	Beta-secretase 2		 135								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370666	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370666&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264065	402357646							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733238	COc1cnc2c(Nc3ccc4OCC[C@H]5[C@](C)(NC(=N)N(C)S5(=O)=O)c4c3)ccnc2c1	InChI=1S/C22H24N6O4S/c1-22-15-10-13(26-16-6-8-24-17-11-14(31-3)12-25-20(16)17)4-5-18(15)32-9-7-19(22)33(29,30)28(2)21(23)27-22/h4-6,8,10-12,19H,7,9H2,1-3H3,(H2,23,27)(H,24,26)/t19-,22+/m0/s1	VQDBEIDPOZRASW-SIKLNZKXSA-N	370667	US10238743, Example 42	Beta-secretase 2		 1787								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370667	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370667&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264068	402357647							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733240	COc1cnc2c(Nc3ccc4OCC[C@H]5[C@](C)(NC(=N)N(C)S5(=O)=O)c4c3)nccc2c1	InChI=1S/C22H24N6O4S/c1-22-16-11-14(26-20-19-13(6-8-24-20)10-15(31-3)12-25-19)4-5-17(16)32-9-7-18(22)33(29,30)28(2)21(23)27-22/h4-6,8,10-12,18H,7,9H2,1-3H3,(H2,23,27)(H,24,26)/t18-,22+/m0/s1	QQQQOCVJTRKGNQ-PGRDOPGGSA-N	370668	US10238743, Example 43	Beta-secretase 2		 148								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370668	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370668&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264092	402357648							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733242	COc1cnc2c(Nc3ccc4CCC[C@H]5[C@](C)(NC(=N)N(C)S5(=O)=O)c4c3)nccc2n1	InChI=1S/C22H25N7O3S/c1-22-15-11-14(26-20-19-16(9-10-24-20)27-18(32-3)12-25-19)8-7-13(15)5-4-6-17(22)33(30,31)29(2)21(23)28-22/h7-12,17H,4-6H2,1-3H3,(H2,23,28)(H,24,26)/t17-,22+/m0/s1	WJQUEGMQBAZKLH-HTAPYJJXSA-N	370669	US10238743, Example 44	Beta-secretase 2		 173								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370669&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264070	402357649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733244	COc1cnc2c(Nc3ccc4CCC[C@H]5[C@](C)(NC(=N)N(C)S5(=O)=O)c4c3)ccnc2n1	InChI=1S/C22H25N7O3S/c1-22-15-11-14(26-16-9-10-24-20-19(16)25-12-18(27-20)32-3)8-7-13(15)5-4-6-17(22)33(30,31)29(2)21(23)28-22/h7-12,17H,4-6H2,1-3H3,(H2,23,28)(H,24,26,27)/t17-,22+/m0/s1	QXHIESZXBBBMJR-HTAPYJJXSA-N	370670	US10238743, Example 45	Beta-secretase 2		 2439								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370670	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370670&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264064	402357650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733246	COc1cnc2c(Nc3ccc4CCC[C@H]5[C@](C)(NC(=N)N(C)S5(=O)=O)c4c3)nccc2c1	InChI=1S/C23H26N6O3S/c1-23-18-12-16(27-21-20-15(9-10-25-21)11-17(32-3)13-26-20)8-7-14(18)5-4-6-19(23)33(30,31)29(2)22(24)28-23/h7-13,19H,4-6H2,1-3H3,(H2,24,28)(H,25,27)/t19-,23+/m0/s1	NIWDAVIAMIRGTH-WMZHIEFXSA-N	370671	US10238743, Example 46	Beta-secretase 2		 251								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370671	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370671&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264431	402357651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733248	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NC4CCCC4)cc23)S1(=O)=O	InChI=1S/C18H26N4O3S/c1-18-14-11-13(20-12-5-3-4-6-12)7-8-15(14)25-10-9-16(18)26(23,24)22(2)17(19)21-18/h7-8,11-12,16,20H,3-6,9-10H2,1-2H3,(H2,19,21)/t16-,18+/m0/s1	RWPYRLCUTYIVDS-FUHWJXTLSA-N	370672	US10238743, Example 47	Beta-secretase 2		 716								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370672	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370672&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264532	402357652							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733250	CN1C(=N)N[C@@]2(C)[C@H](CCOc3ccc(NCC4CC4)cc23)S1(=O)=O	InChI=1S/C17H24N4O3S/c1-17-13-9-12(19-10-11-3-4-11)5-6-14(13)24-8-7-15(17)25(22,23)21(2)16(18)20-17/h5-6,9,11,15,19H,3-4,7-8,10H2,1-2H3,(H2,18,20)/t15-,17+/m0/s1	BOTBIBLHJMSJGQ-DOTOQJQBSA-N	370673	US10238743, Example 48	Beta-secretase 2		 2013								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370673&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264533	402357653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
733252	CCCNc1ccc2OCC[C@H]3[C@](C)(NC(=N)N(C)S3(=O)=O)c2c1	InChI=1S/C16H24N4O3S/c1-4-8-18-11-5-6-13-12(10-11)16(2)14(7-9-23-13)24(21,22)20(3)15(17)19-16/h5-6,10,14,18H,4,7-9H2,1-3H3,(H2,17,19)/t14-,16+/m0/s1	RKYXWWPVBNXJLB-GOEBONIOSA-N	370674	US10238743, Example 49	Beta-secretase 2		 1976								US Patent		10.7270/Q2JQ13BX		aid1798130	US10238743	He, S; Cumming, JN; Scott, JD	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370674	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370674&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264556	402357654							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739568	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3nnc(C)o3)cn2)ccc1F	InChI=1S/C25H25F2N7O3S/c1-13-32-33-21(37-13)12-36-20-11-29-18(10-30-20)17(27)8-14-5-6-16(26)15(7-14)24(2)19-9-25(19,22(35)34(3)4)38-23(28)31-24/h5-8,10-11,19H,9,12H2,1-4H3,(H2,28,31)/b17-8-/t19-,24+,25-/m0/s1	YZWWSXPOUJZECH-UMCZMAMBSA-N	372800	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((5-methyl-1,3,4-oxadiazol-2-yl)methoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 216	Beta-secretase 2			 72.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372800&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285482	402359736							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739571	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3nc(C)no3)cn2)ccc1F	InChI=1S/C25H25F2N7O3S/c1-13-31-21(37-33-13)12-36-20-11-29-18(10-30-20)17(27)8-14-5-6-16(26)15(7-14)24(2)19-9-25(19,22(35)34(3)4)38-23(28)32-24/h5-8,10-11,19H,9,12H2,1-4H3,(H2,28,32)/b17-8-/t19-,24+,25-/m0/s1	USKUAHWTBULDMG-UMCZMAMBSA-N	372801	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((3-methyl-1,2,4-oxadiazol-5-yl)methoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 217	Beta-secretase 2			 70.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372801&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555100	402359737							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739574	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3cc(C)no3)cn2)ccc1F	InChI=1S/C26H26F2N6O3S/c1-14-7-16(37-33-14)13-36-22-12-30-20(11-31-22)19(28)9-15-5-6-18(27)17(8-15)25(2)21-10-26(21,23(35)34(3)4)38-24(29)32-25/h5-9,11-12,21H,10,13H2,1-4H3,(H2,29,32)/b19-9-/t21-,25+,26-/m0/s1	QWGNZHGLGDDLOU-QESUPJEVSA-N	372802	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((3-methylisoxazol-5-yl)methoxy)pyrazin-2-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 218	Beta-secretase 2			 33.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372802&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524620	402359738							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739577	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ncc(s2)C#N)ccc1F	InChI=1S/C21H19F2N5OS2/c1-20(16-8-21(16,18(29)28(2)3)31-19(25)27-20)13-6-11(4-5-14(13)22)7-15(23)17-26-10-12(9-24)30-17/h4-7,10,16H,8H2,1-3H3,(H2,25,27)/b15-7-/t16-,20+,21-/m0/s1	HUYMMLBCNOXXQM-PLLJPQRWSA-N	372803	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanothiazol-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 219	Beta-secretase 2			 7.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372803&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557182	402359739							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739580	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(s2)C#N)ccc1F	InChI=1S/C22H20F2N4OS2/c1-21(18-10-22(18,19(29)28(2)3)31-20(26)27-21)14-8-12(4-6-15(14)23)9-16(24)17-7-5-13(11-25)30-17/h4-9,18H,10H2,1-3H3,(H2,26,27)/b16-9-/t18-,21+,22-/m0/s1	KADCOBWPLLZJEJ-LLYJTOGPSA-N	372804	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanothiophen-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 220	Beta-secretase 2			 2.00							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372804&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557118	402359740							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739583	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C(\F)=C\c1ccc(cc1)C#N	InChI=1S/C24H22F2N4OS/c1-23(20-12-24(20,21(31)30(2)3)32-22(28)29-23)17-11-16(8-9-18(17)25)19(26)10-14-4-6-15(13-27)7-5-14/h4-11,20H,12H2,1-3H3,(H2,28,29)/b19-10-/t20-,23+,24-/m0/s1	HZZFSMGJPIYQAR-KHTKAAKSSA-N	372783	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(4-cyanophenyl)-1-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 186::US10246429, Example 221	Beta-secretase 2			 302							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557184	402359719							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739586	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H19F2N5OS/c1-21(18-9-22(18,19(30)27-2)31-20(26)29-21)14-7-12(3-5-15(14)23)8-16(24)17-6-4-13(10-25)11-28-17/h3-8,11,18H,9H2,1-2H3,(H2,26,29)(H,27,30)/b16-8-/t18-,21+,22-/m0/s1	XXLIOBKVJNBTMS-ZKMBLFMTSA-N	372806	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 222	Beta-secretase 2			 91.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372806&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556763	402359741							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739589	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C21H18F2N6OS/c1-20(17-7-21(17,18(30)26-2)31-19(25)29-20)13-5-11(3-4-14(13)22)6-15(23)16-10-27-12(8-24)9-28-16/h3-6,9-10,17H,7H2,1-2H3,(H2,25,29)(H,26,30)/b15-6-/t17-,20+,21-/m0/s1	VOOFSJSMHWHJPL-ZSWMORAZSA-N	372807	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 223	Beta-secretase 2			 80.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372807&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555026	402359742							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739592	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C22H19F5N4OS/c1-20(17-9-21(17,18(32)29-2)33-19(28)31-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(10-30-16)22(25,26)27/h3-8,10,17H,9H2,1-2H3,(H2,28,31)(H,29,32)/b15-8-/t17-,20+,21-/m0/s1	FVSVPSYLOWTSHK-NZUJZPRYSA-N	372808	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(trifluoromethyl)pyridin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 224	Beta-secretase 2			 564							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372808&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556857	402359743							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739595	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C23H21F2N5OS/c1-12-6-14(10-26)11-29-19(12)17(25)8-13-4-5-16(24)15(7-13)22(2)18-9-23(18,20(31)28-3)32-21(27)30-22/h4-8,11,18H,9H2,1-3H3,(H2,27,30)(H,28,31)/b17-8-/t18-,22+,23-/m0/s1	PXGVBAVSVKPASH-YWICPGKJSA-N	372809	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyano-3-methylpyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 225	Beta-secretase 2			 621							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372809&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555352	402359744							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739598	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3cnco3)cn2)ccc1F	InChI=1S/C24H22F2N6O3S/c1-23(19-7-24(19,21(33)28-2)36-22(27)32-23)15-5-13(3-4-16(15)25)6-17(26)18-9-31-20(10-30-18)34-11-14-8-29-12-35-14/h3-6,8-10,12,19H,7,11H2,1-2H3,(H2,27,32)(H,28,33)/b17-6-/t19-,23+,24-/m0/s1	SVAZGBSHBQTVDM-JHFWHATFSA-N	372810	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(oxazol-5-ylmethoxy)pyrazin-2-yl)vinyl)phenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 226	Beta-secretase 2			 285							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372810&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557192	402359745							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739601	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)S(C)(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H20F2N4O3S2/c1-4-7-31-19-12-26-17(11-27-19)16(24)9-13-5-6-15(23)14(8-13)21(2)18-10-22(18,33(3,29)30)32-20(25)28-21/h1,5-6,8-9,11-12,18H,7,10H2,2-3H3,(H2,25,28)/b16-9-/t18-,21+,22+/m0/s1	WATKSQNPDRPROG-XJIPBONXSA-N	372811	(1R,5S,6S)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 227	Beta-secretase 2			 58.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372811&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285462	402359746							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739604	Cc1nnc(COc2cnc(cn2)C(\F)=C\c2ccc(F)c(c2)[C@@]2(C)N=C(N)S[C@]3(C[C@@H]23)S(C)(=O)=O)o1	InChI=1S/C23H22F2N6O4S2/c1-12-30-31-20(35-12)11-34-19-10-27-17(9-28-19)16(25)7-13-4-5-15(24)14(6-13)22(2)18-8-23(18,37(3,32)33)36-21(26)29-22/h4-7,9-10,18H,8,11H2,1-3H3,(H2,26,29)/b16-7-/t18-,22+,23+/m0/s1	MERYWODKTRQASW-LKONLRGWSA-N	372812	(1R,5S,6S)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-((5-methyl-1,3,4-oxadiazol-2-yl)methoxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 228	Beta-secretase 2			 292							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372812&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285403	402359747							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739607	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)S(C)(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C21H19F5N4O3S2/c1-19(16-7-20(16,35(2,31)32)34-18(27)30-19)12-5-11(3-4-13(12)22)6-14(23)15-8-29-17(9-28-15)33-10-21(24,25)26/h3-6,8-9,16H,7,10H2,1-2H3,(H2,27,30)/b14-6-/t16-,19+,20+/m0/s1	ZTUZJEHLQLTKMH-JNBPKBJUSA-N	372813	(1R,5S,6S)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,2-trifluoroethoxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 229	Beta-secretase 2			 85.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372813&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557195	402359748							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739610	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)S(C)(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C19H17ClF2N4O2S2/c1-18(15-7-19(15,30(2,27)28)29-17(23)26-18)11-5-10(3-4-12(11)21)6-13(22)14-8-25-16(20)9-24-14/h3-6,8-9,15H,7H2,1-2H3,(H2,23,26)/b13-6-/t15-,18+,19+/m0/s1	RACZYCUUTKISCV-OCVCIRIZSA-N	372814	(1R,5S,6S)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 230	Beta-secretase 2			 11.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372814&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556863	402359749							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739613	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)S(C)(=O)=O	InChI=1S/C23H22F2N4O3S2/c1-4-5-8-32-20-13-27-18(12-28-20)17(25)10-14-6-7-16(24)15(9-14)22(2)19-11-23(19,34(3,30)31)33-21(26)29-22/h6-7,9-10,12-13,19H,8,11H2,1-3H3,(H2,26,29)/b17-10-/t19-,22+,23+/m0/s1	BKSJVUKEEUFBSI-ITHVVHDKSA-N	372815	(1R,5S,6S)-5-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 231	Beta-secretase 2			 30.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372815&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524075	402359750							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739616	C[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)S(C)(=O)=O)C#C	InChI=1S/C23H22F2N4O3S2/c1-5-13(2)32-20-12-27-18(11-28-20)17(25)9-14-6-7-16(24)15(8-14)22(3)19-10-23(19,34(4,30)31)33-21(26)29-22/h1,6-9,11-13,19H,10H2,2-4H3,(H2,26,29)/b17-9-/t13-,19-,22+,23+/m0/s1	FDHHRWRYGLMHDI-XIMBKFHCSA-N	372816	(1R,5S,6S)-5-(5-((Z)-2-(5-((S)-but-3-yn-2-yloxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 232	Beta-secretase 2			 108							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372816&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523872	402359751							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739619	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)S(C)(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H18F2N4O2S2/c1-20(18-9-21(18,31(2,28)29)30-19(25)27-20)14-7-12(3-5-15(14)22)8-16(23)17-6-4-13(10-24)11-26-17/h3-8,11,18H,9H2,1-2H3,(H2,25,27)/b16-8-/t18-,20+,21+/m0/s1	GFASAWMOOYRMJU-WYVHCHOOSA-N	372817	6-((Z)-2-(3-((1R,5S,6S)-3-amino-5-methyl-1-(methylsulfonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 233	Beta-secretase 2			 14.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372817&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285478	402359752							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739622	CC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C23H20F2N4O2S/c1-4-7-31-20-12-27-18(11-28-20)17(25)9-14-5-6-16(24)15(8-14)22(3)19-10-23(19,13(2)30)32-21(26)29-22/h1,5-6,8-9,11-12,19H,7,10H2,2-3H3,(H2,26,29)/b17-9-/t19-,22+,23+/m0/s1	VZDYBRKATAOFCN-PIGXPCJYSA-N	372818	1-((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)ethanone::US10246429, Example 234	Beta-secretase 2			 581							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372818&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524744	402359753							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739625	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(C)=O	InChI=1S/C24H22F2N4O2S/c1-4-5-8-32-21-13-28-19(12-29-21)18(26)10-15-6-7-17(25)16(9-15)23(3)20-11-24(20,14(2)31)33-22(27)30-23/h6-7,9-10,12-13,20H,8,11H2,1-3H3,(H2,27,30)/b18-10-/t20-,23+,24+/m0/s1	KJHZTBSKBYEHQO-OKPMIQMTSA-N	372819	1-((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)ethanone::US10246429, Example 235	Beta-secretase 2			 247							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372819	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372819&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285425	402359754							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739628	CC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C22H19F5N4O2S/c1-11(32)21-7-17(21)20(2,31-19(28)34-21)13-5-12(3-4-14(13)23)6-15(24)16-8-30-18(9-29-16)33-10-22(25,26)27/h3-6,8-9,17H,7,10H2,1-2H3,(H2,28,31)/b15-6-/t17-,20+,21+/m0/s1	ZUIIBOOGEQFYMD-AVTOPLFFSA-N	372820	1-((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,2-trifluoroethoxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)ethanone::US10246429, Example 236	Beta-secretase 2			 1280							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372820	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372820&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285427	402359755							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739631	C[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(C)=O)C#C	InChI=1S/C24H22F2N4O2S/c1-5-13(2)32-21-12-28-19(11-29-21)18(26)9-15-6-7-17(25)16(8-15)23(4)20-10-24(20,14(3)31)33-22(27)30-23/h1,6-9,11-13,20H,10H2,2-4H3,(H2,27,30)/b18-9-/t13-,20-,23+,24+/m0/s1	DHCXLPMQECZENY-MCGFEWDGSA-N	372821	1-((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-((S)-but-3-yn-2-yloxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)ethanone::US10246429, Example 237	Beta-secretase 2			 438							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372821&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126554901	402359756							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739634	CC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H18F2N4OS/c1-12(29)22-9-19(22)21(2,28-20(26)30-22)15-7-13(3-5-16(15)23)8-17(24)18-6-4-14(10-25)11-27-18/h3-8,11,19H,9H2,1-2H3,(H2,26,28)/b17-8-/t19-,21+,22+/m0/s1	BXVBTUULDWOVOF-FQRJWFRCSA-N	372822	6-((Z)-2-(3-((1S,5S,6S)-1-acetyl-3-amino-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 238	Beta-secretase 2			 245							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372822	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372822&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126558779	402359757							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739637	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(N)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H19F2N5O2S/c1-3-6-31-18-11-27-16(10-28-18)15(24)8-12-4-5-14(23)13(7-12)21(2)17-9-22(17,19(25)30)32-20(26)29-21/h1,4-5,7-8,10-11,17H,6,9H2,2H3,(H2,25,30)(H2,26,29)/b15-8-/t17-,21+,22-/m0/s1	BFWGHXSMTZQEFO-WYOHQZQDSA-N	372823	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 239	Beta-secretase 2			 177							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372823	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372823&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556757	402359758							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739640	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C#N)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H17F2N5OS/c1-3-6-30-19-11-27-17(10-28-19)16(24)8-13-4-5-15(23)14(7-13)21(2)18-9-22(18,12-25)31-20(26)29-21/h1,4-5,7-8,10-11,18H,6,9H2,2H3,(H2,26,29)/b16-8-/t18-,21+,22+/m0/s1	RTIWDSCRBVYFLG-MJPIYPAMSA-N	372829	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carbonitrile::US10246429, Example 240	Beta-secretase 2			 81.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372829	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372829&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285405	402359764							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739643	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(N)=O	InChI=1S/C23H21F2N5O2S/c1-3-4-7-32-19-12-28-17(11-29-19)16(25)9-13-5-6-15(24)14(8-13)22(2)18-10-23(18,20(26)31)33-21(27)30-22/h5-6,8-9,11-12,18H,7,10H2,1-2H3,(H2,26,31)(H2,27,30)/b16-9-/t18-,22+,23-/m0/s1	NNXXSMMVPWTXHI-JLUYBFTRSA-N	372830	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 241	Beta-secretase 2			 115							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372830	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372830&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557058	402359765							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739646	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(N)=O)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H17ClF2N4OS/c1-19(16-8-20(16,17(24)28)29-18(25)27-19)12-6-10(2-4-13(12)22)7-14(23)15-5-3-11(21)9-26-15/h2-7,9,16H,8H2,1H3,(H2,24,28)(H2,25,27)/b14-7-/t16-,19+,20-/m0/s1	ZRMOHAFBLTVHGJ-USPQDSGZSA-N	372831	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 242	Beta-secretase 2			 34.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372831	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372831&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557720	402359766							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739649	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(N)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H17F2N5OS/c1-20(17-8-21(17,18(25)29)30-19(26)28-20)13-6-11(2-4-14(13)22)7-15(23)16-5-3-12(9-24)10-27-16/h2-7,10,17H,8H2,1H3,(H2,25,29)(H2,26,28)/b15-7-/t17-,20+,21-/m0/s1	BUVWCCPQMQXFJD-KUDAXZBBSA-N	372832	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 243	Beta-secretase 2			 43.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372832	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372832&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555282	402359767							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739652	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C#N	InChI=1S/C23H19F2N5OS/c1-3-4-7-31-20-12-28-18(11-29-20)17(25)9-14-5-6-16(24)15(8-14)22(2)19-10-23(19,13-26)32-21(27)30-22/h5-6,8-9,11-12,19H,7,10H2,1-2H3,(H2,27,30)/b17-9-/t19-,22+,23+/m0/s1	IOARFOYMAGIOGC-PIGXPCJYSA-N	372833	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carbonitrile::US10246429, Example 244	Beta-secretase 2			 55.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372833	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372833&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285434	402359768							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739655	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C#N)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H15F2N5S/c1-20(18-8-21(18,11-25)29-19(26)28-20)14-6-12(2-4-15(14)22)7-16(23)17-5-3-13(9-24)10-27-17/h2-7,10,18H,8H2,1H3,(H2,26,28)/b16-7-/t18-,20+,21+/m0/s1	BWYRAQSHPCCAPW-PRQBLYAZSA-N	372834	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carbonitrile::US10246429, Example 245	Beta-secretase 2			 57.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372834	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372834&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555283	402359769							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739658	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cn3cc(ccc3n2)C#N)ccc1F	InChI=1S/C25H22F2N6OS/c1-24(20-10-25(20,22(34)32(2)3)35-23(29)31-24)16-8-14(4-6-17(16)26)9-18(27)19-13-33-12-15(11-28)5-7-21(33)30-19/h4-9,12-13,20H,10H2,1-3H3,(H2,29,31)/b18-9-/t20-,24+,25-/m0/s1	AHTIQAIERQCYSY-LKXBDJSQSA-N	372835	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(6-cyanoimidazo[1,2-a]pyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 246	Beta-secretase 2			 390							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372835	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372835&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285453	402359770							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739661	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cc3nccnc3cn2)ccc1F	InChI=1S/C24H22F2N6OS/c1-23(20-11-24(20,21(33)32(2)3)34-22(27)31-23)14-8-13(4-5-15(14)25)9-16(26)17-10-18-19(12-30-17)29-7-6-28-18/h4-10,12,20H,11H2,1-3H3,(H2,27,31)/b16-9-/t20-,23+,24-/m0/s1	KMBSVVYIQKJTAT-UELTYCCSSA-N	372836	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(pyrido[3,4-b]pyrazin-7-yl)vinyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 247	Beta-secretase 2			 385							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372836	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372836&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285432	402359771							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739664	COC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C21H17ClF3N3O2S/c1-20(16-8-21(16,18(29)30-2)31-19(26)28-20)12-5-10(7-14(24)17(12)25)6-13(23)15-4-3-11(22)9-27-15/h3-7,9,16H,8H2,1-2H3,(H2,26,28)/b13-6-/t16-,20+,21-/m0/s1	GUUHNBCLJRRGLE-QQWCOGLLSA-N	372837	(1S,5S,6S)-methyl 3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2,3-difluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 248	Beta-secretase 2			 83.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372837&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555281	402359772							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739667	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cc3OCCOc3cn2)ccc1F	InChI=1S/C23H22F2N4O3S/c1-22(19-10-23(19,20(30)27-2)33-21(26)29-22)13-7-12(3-4-14(13)24)8-15(25)16-9-17-18(11-28-16)32-6-5-31-17/h3-4,7-9,11,19H,5-6,10H2,1-2H3,(H2,26,29)(H,27,30)/b15-8-/t19-,22+,23-/m0/s1	BJFIQQLHDVZBOG-PPXYPUDMSA-N	372838	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-2-fluorovinyl)-2-fluorophenyl)-N,5-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 249	Beta-secretase 2			 503							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372838	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372838&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557140	402359773							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739670	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2ncc3OCCOc3n2)ccc1F	InChI=1S/C23H23F2N5O3S/c1-22(17-10-23(17,20(31)30(2)3)34-21(26)29-22)13-8-12(4-5-14(13)24)9-15(25)18-27-11-16-19(28-18)33-7-6-32-16/h4-5,8-9,11,17H,6-7,10H2,1-3H3,(H2,26,29)/b15-9-/t17-,22+,23-/m0/s1	OISXFDYMIVVSMD-YYYFVPBLSA-N	372839	(1S,5S,6S)-3-amino-5-(5-((Z)-2-(6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10246429, Example 250	Beta-secretase 2			 76.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372839	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372839&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555030	402359774							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739673	COc1ccc(CNC2=N[C@@](C)([C@@H]3C(F)(F)[C@]3(CO)S2)c2cc(\C=C(/F)c3ccc(cn3)C#N)ccc2F)cc1	InChI=1S/C29H24F4N4O2S/c1-27(21-11-18(5-9-22(21)30)12-23(31)24-10-6-19(13-34)15-35-24)25-28(16-38,29(25,32)33)40-26(37-27)36-14-17-3-7-20(39-2)8-4-17/h3-12,15,25,38H,14,16H2,1-2H3,(H,36,37)/b23-12-/t25?,27-,28-/m1/s1	REDXDPVAZZMKTM-UPFHGNMBSA-N	372840	6-((Z)-2-(3-((1S,5S,6R)-3-amino-7,7-difluoro-1-(hydroxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 251	Beta-secretase 2			 159							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372840	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372840&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137033522	402359775							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739676	C[C@@]1(N=C(N)S[C@]2(CO)[C@H]1C2(F)F)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C19H15ClF4N4OS/c1-17(15-18(8-29,19(15,23)24)30-16(25)28-17)10-4-9(2-3-11(10)21)5-12(22)13-6-27-14(20)7-26-13/h2-7,15,29H,8H2,1H3,(H2,25,28)/b12-5-/t15-,17+,18+/m0/s1	GVMSVHLCVOJVER-LPKPKNFYSA-N	372841	((1S,5S,6R)-3-amino-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-7,7-difluoro-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)methanol::US10246429, Example 252	Beta-secretase 2			 151							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372841	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372841&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555288	402359776							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739679	C[C@@]1(N=C(N)S[C@]2(CO)[C@H]1C2(F)F)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H18F4N4O2S/c1-3-6-32-17-10-28-16(9-29-17)15(24)8-12-4-5-14(23)13(7-12)20(2)18-21(11-31,22(18,25)26)33-19(27)30-20/h1,4-5,7-10,18,31H,6,11H2,2H3,(H2,27,30)/b15-8-/t18-,20+,21+/m0/s1	LNAZJEOWFRKMPV-FJLUVNQOSA-N	372842	((1S,5S,6R)-3-amino-7,7-difluoro-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)methanol::US10246429, Example 253	Beta-secretase 2			 385							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372842	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372842&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555248	402359777							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739682	C[C@@]1(N=C(N)S[C@]2(CO)[C@H]1C2(F)F)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C20H15F4N5OS/c1-18(16-19(9-30,20(16,23)24)31-17(26)29-18)12-4-10(2-3-13(12)21)5-14(22)15-8-27-11(6-25)7-28-15/h2-5,7-8,16,30H,9H2,1H3,(H2,26,29)/b14-5-/t16-,18+,19+/m0/s1	LMJBWNJQVGHCHT-AQYUHIHWSA-N	372844	5-((Z)-2-(3-((1S,5S,6R)-3-amino-7,7-difluoro-1-(hydroxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)pyrazine-2-carbonitrile trifluoromethyl acetate::US10246429, Example 254	Beta-secretase 2			 82.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372844&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126556897	402359779							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739685	C[C@@]1(N=C(N)S[C@]2(CO)[C@H]1C2(F)F)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H16ClF4N3OS/c1-18(16-19(9-29,20(16,24)25)30-17(26)28-18)12-6-10(2-4-13(12)22)7-14(23)15-5-3-11(21)8-27-15/h2-8,16,29H,9H2,1H3,(H2,26,28)/b14-7-/t16-,18+,19+/m0/s1	DJANIPFHGUAKPD-HREYTAOQSA-N	372845	((1S,5S,6R)-3-amino-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-7,7-difluoro-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)methanol::US10246429, Example 255	Beta-secretase 2			 56.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372845	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372845&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557608	402359780							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739688	COC(=O)[C@@]12SC(N)=N[C@@](C)([C@@H]1C2(F)F)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H16F4N4O2S/c1-20(17-21(18(31)32-2,22(17,25)26)33-19(28)30-20)13-7-11(3-5-14(13)23)8-15(24)16-6-4-12(9-27)10-29-16/h3-8,10,17H,1-2H3,(H2,28,30)/b15-8-/t17-,20+,21-/m0/s1	QESMDGIJFXOIBX-NZUJZPRYSA-N	372846	(1S,5S,6R)-methyl 3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-7,7-difluoro-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxylate::US10246429, Example 256	Beta-secretase 2			 252							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372846	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372846&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557173	402359781							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739691	CC(C)(O)[C@@]12SC(N)=N[C@@](C)([C@@H]1C2(F)F)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C23H20F4N4OS/c1-20(2,32)22-18(23(22,26)27)21(3,31-19(29)33-22)14-8-12(4-6-15(14)24)9-16(25)17-7-5-13(10-28)11-30-17/h4-9,11,18,32H,1-3H3,(H2,29,31)/b16-9-/t18-,21+,22-/m0/s1	XULKTEJAVBVPNX-LLYJTOGPSA-N	372847	6-((Z)-2-(3-((1S,5S,6R)-3-amino-7,7-difluoro-1-(2-hydroxypropan-2-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile trifluoromethyl acetate::US10246429, Example 257	Beta-secretase 2			 208							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372847	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372847&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557170	402359782							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739694	COC[C@@]12SC(N)=N[C@@](C)([C@@H]1C2(F)F)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H18F4N4OS/c1-20(18-21(11-31-2,22(18,25)26)32-19(28)30-20)14-7-12(3-5-15(14)23)8-16(24)17-6-4-13(9-27)10-29-17/h3-8,10,18H,11H2,1-2H3,(H2,28,30)/b16-8-/t18-,20+,21+/m0/s1	IIHREPZOXKKXEE-WYVHCHOOSA-N	372848	6-((Z)-2-(3-((1S,5S,6R)-3-amino-7,7-difluoro-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 258	Beta-secretase 2			 118							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372848	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372848&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555302	402359783							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739697	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC(F)(F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C24H20F4N6OS/c1-22(18-8-24(18,36-21(30)33-22)20(35)34-5-4-23(27,28)12-34)15-6-14(11-32-19(15)26)7-16(25)17-3-2-13(9-29)10-31-17/h2-3,6-7,10-11,18H,4-5,8,12H2,1H3,(H2,30,33)/b16-7-/t18-,22+,24-/m0/s1	BMERFWVSUFPSKD-GETCWEEDSA-N	372849	6-((Z)-2-(5-((1S,5S,6S)-3-amino-1-(3,3-difluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 259	Beta-secretase 2			 113							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372849&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126523877	402359784							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739700	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC(F)(F)CC1)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C25H22F4N6OS/c1-23(16-8-15(13-33-20(16)27)9-17(26)18-3-2-14(11-30)12-32-18)19-10-25(19,37-22(31)34-23)21(36)35-6-4-24(28,29)5-7-35/h2-3,8-9,12-13,19H,4-7,10H2,1H3,(H2,31,34)/b17-9-/t19-,23+,25-/m0/s1	AZFBHYHKQYNMKH-IBNCNETESA-N	372850	6-((Z)-2-(5-((1S,5S,6S)-3-amino-1-(4,4-difluoropiperidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 260	Beta-secretase 2			 115							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372850	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372850&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126524071	402359785							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739703	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C20H19ClF2N4OS/c1-19(16-7-20(16,10-28-2)29-18(24)27-19)12-5-11(3-4-13(12)22)6-14(23)15-8-26-17(21)9-25-15/h3-6,8-9,16H,7,10H2,1-2H3,(H2,24,27)/b14-6-/t16-,19+,20+/m0/s1	FXSJKWRRSDJDGV-JNBPKBJUSA-N	372851	(1S,5S,6S)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10246429, Example 261	Beta-secretase 2			 80.0							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372851	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372851&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557181	402359786							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739706	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C23H22F2N4O2S/c1-4-7-31-20-12-27-18(11-28-20)17(25)9-14-5-6-16(24)15(8-14)22(2)19-10-23(19,13-30-3)32-21(26)29-22/h1,5-6,8-9,11-12,19H,7,10,13H2,2-3H3,(H2,26,29)/b17-9-/t19-,22+,23+/m0/s1	AZFGENOAMJOZTC-PIGXPCJYSA-N	372852	(1S,5S,6S)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine.::US10246429, Example 262	Beta-secretase 2			 694							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372852	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372852&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285388	402359787							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739709	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC#CC)cn2)ccc1F	InChI=1S/C24H24F2N4O2S/c1-4-5-8-32-21-13-28-19(12-29-21)18(26)10-15-6-7-17(25)16(9-15)23(2)20-11-24(20,14-31-3)33-22(27)30-23/h6-7,9-10,12-13,20H,8,11,14H2,1-3H3,(H2,27,30)/b18-10-/t20-,23+,24+/m0/s1	XFUMHMKHRITTLF-OKPMIQMTSA-N	372853	US10246429, Example 263	Beta-secretase 2			 1840							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372853	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372853&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555289	402359788							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739712	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(O[C@@H](C)C#C)cn2)ccc1F	InChI=1S/C24H24F2N4O2S/c1-5-14(2)32-21-12-28-19(11-29-21)18(26)9-15-6-7-17(25)16(8-15)23(3)20-10-24(20,13-31-4)33-22(27)30-23/h1,6-9,11-12,14,20H,10,13H2,2-4H3,(H2,27,30)/b18-9-/t14-,20-,23+,24+/m0/s1	TZPMVFBCNRGHHQ-YYYSQDMTSA-N	372854	US10246429, Example 264	Beta-secretase 2			 917							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372854&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126555287	402359789							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739715	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OC[C@H](C)OC)cn2)ccc1F	InChI=1S/C24H28F2N4O3S/c1-14(32-4)12-33-21-11-28-19(10-29-21)18(26)8-15-5-6-17(25)16(7-15)23(2)20-9-24(20,13-31-3)34-22(27)30-23/h5-8,10-11,14,20H,9,12-13H2,1-4H3,(H2,27,30)/b18-8-/t14-,20-,23+,24+/m0/s1	LXPDDSHUEBLIMV-HCIDPQOSSA-N	372855	US10246429, Example 265	Beta-secretase 2			 3860							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372855&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285392	402359790							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739718	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)F)cn2)ccc1F	InChI=1S/C22H22F4N4O2S/c1-21(17-7-22(17,11-31-2)33-20(27)30-21)13-5-12(3-4-14(13)23)6-15(24)16-8-29-19(9-28-16)32-10-18(25)26/h3-6,8-9,17-18H,7,10-11H2,1-2H3,(H2,27,30)/b15-6-/t17-,21+,22+/m0/s1	QGOCJUNAIACPHY-CIUNRPGCSA-N	372856	US10246429, Example 266	Beta-secretase 2			 1580							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372856&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285419	402359791							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739721	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C22H21F5N4O2S/c1-20(17-7-21(17,10-32-2)34-19(28)31-20)13-5-12(3-4-14(13)23)6-15(24)16-8-30-18(9-29-16)33-11-22(25,26)27/h3-6,8-9,17H,7,10-11H2,1-2H3,(H2,28,31)/b15-6-/t17-,20+,21+/m0/s1	VJYNCMOMESNFNS-AVTOPLFFSA-N	372857	US10246429, Example 267	Beta-secretase 2			 1730							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372857&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285441	402359792							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739724	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCCC(F)(F)F)cn2)ccc1F	InChI=1S/C23H23F5N4O2S/c1-21(18-9-22(18,12-33-2)35-20(29)32-21)14-7-13(3-4-15(14)24)8-16(25)17-10-31-19(11-30-17)34-6-5-23(26,27)28/h3-4,7-8,10-11,18H,5-6,9,12H2,1-2H3,(H2,29,32)/b16-8-/t18-,21+,22+/m0/s1	UXDBRFGNPMGRII-MJPIYPAMSA-N	372859	US10246429, Example 268	Beta-secretase 2			 1550							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372859&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285431	402359794							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739727	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCCF)cn2)ccc1F	InChI=1S/C22H23F3N4O2S/c1-21(18-9-22(18,12-30-2)32-20(26)29-21)14-7-13(3-4-15(14)24)8-16(25)17-10-28-19(11-27-17)31-6-5-23/h3-4,7-8,10-11,18H,5-6,9,12H2,1-2H3,(H2,26,29)/b16-8-/t18-,21+,22+/m0/s1	MWWSBMQBTHUTEH-MJPIYPAMSA-N	372862	US10246429, Example 269	Beta-secretase 2			 1140							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372862&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285410	402359797							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739730	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3CC3)cn2)ccc1F	InChI=1S/C24H26F2N4O2S/c1-23(20-9-24(20,13-31-2)33-22(27)30-23)16-7-15(5-6-17(16)25)8-18(26)19-10-29-21(11-28-19)32-12-14-3-4-14/h5-8,10-11,14,20H,3-4,9,12-13H2,1-2H3,(H2,27,30)/b18-8-/t20-,23+,24+/m0/s1	RXAXGCGOEFTXCK-AGCMOHSRSA-N	372863	US10246429, Example 270	Beta-secretase 2			 1220							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372863&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285402	402359798							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739733	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3CCC3)cn2)ccc1F	InChI=1S/C25H28F2N4O2S/c1-24(21-10-25(21,14-32-2)34-23(28)31-24)17-8-16(6-7-18(17)26)9-19(27)20-11-30-22(12-29-20)33-13-15-4-3-5-15/h6-9,11-12,15,21H,3-5,10,13-14H2,1-2H3,(H2,28,31)/b19-9-/t21-,24+,25+/m0/s1	AHOCSRKOXSHDRM-SGSMAQGXSA-N	372864	US10246429, Example 271	Beta-secretase 2			 1840							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372864&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285420	402359799							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739736	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3COC3)cn2)ccc1F	InChI=1S/C24H26F2N4O3S/c1-23(20-7-24(20,13-31-2)34-22(27)30-23)16-5-14(3-4-17(16)25)6-18(26)19-8-29-21(9-28-19)33-12-15-10-32-11-15/h3-6,8-9,15,20H,7,10-13H2,1-2H3,(H2,27,30)/b18-6-/t20-,23+,24+/m0/s1	OUTOMTGQQPECAT-QKQHWZHFSA-N	372865	US10246429, Example 272	Beta-secretase 2			 4020							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372865&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285385	402359800							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739739	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3CCO3)cn2)ccc1F	InChI=1S/C24H26F2N4O3S/c1-23(20-9-24(20,13-31-2)34-22(27)30-23)16-7-14(3-4-17(16)25)8-18(26)19-10-29-21(11-28-19)33-12-15-5-6-32-15/h3-4,7-8,10-11,15,20H,5-6,9,12-13H2,1-2H3,(H2,27,30)/b18-8-/t15?,20-,23+,24+/m0/s1	UDMRCRQESTYABO-YUAAUURTSA-N	372866	US10246429, Example 273	Beta-secretase 2			 5110							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372866&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126557185	402359801							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739742	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC(C)C)cn2)ccc1F	InChI=1S/C24H28F2N4O2S/c1-14(2)12-32-21-11-28-19(10-29-21)18(26)8-15-5-6-17(25)16(7-15)23(3)20-9-24(20,13-31-4)33-22(27)30-23/h5-8,10-11,14,20H,9,12-13H2,1-4H3,(H2,27,30)/b18-8-/t20-,23+,24+/m0/s1	DSFJJLSGXCWRQR-AGCMOHSRSA-N	372867	US10246429, Example 274	Beta-secretase 2			 2190							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372867&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126554875	402359802							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739745	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3cc(C)on3)cn2)ccc1F	InChI=1S/C25H25F2N5O3S/c1-14-6-16(32-35-14)12-34-22-11-29-20(10-30-22)19(27)8-15-4-5-18(26)17(7-15)24(2)21-9-25(21,13-33-3)36-23(28)31-24/h4-8,10-11,21H,9,12-13H2,1-3H3,(H2,28,31)/b19-8-/t21-,24+,25+/m0/s1	ZOHISMGUQJDZEY-WRXRTWQVSA-N	372868	US10246429, Example 275	Beta-secretase 2			 1200							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372868&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285428	402359803							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739748	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCc3cc(C)no3)cn2)ccc1F	InChI=1S/C25H25F2N5O3S/c1-14-6-16(35-32-14)12-34-22-11-29-20(10-30-22)19(27)8-15-4-5-18(26)17(7-15)24(2)21-9-25(21,13-33-3)36-23(28)31-24/h4-8,10-11,21H,9,12-13H2,1-3H3,(H2,28,31)/b19-8-/t21-,24+,25+/m0/s1	NGQPAWJNGWSCPK-WRXRTWQVSA-N	372869	US10246429, Example 276	Beta-secretase 2			 966							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372869&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285437	402359804							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739751	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OC(C)C(F)(F)F)cn2)ccc1F	InChI=1S/C23H23F5N4O2S/c1-12(23(26,27)28)34-19-10-30-17(9-31-19)16(25)7-13-4-5-15(24)14(6-13)21(2)18-8-22(18,11-33-3)35-20(29)32-21/h4-7,9-10,12,18H,8,11H2,1-3H3,(H2,29,32)/b16-7-/t12?,18-,21+,22+/m0/s1	AEVZKOWCUVUFJD-SOPRDPFNSA-N	372870	US10246429, Example 277	Beta-secretase 2			 2420							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372870&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285387	402359805							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739754	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(\C=C(/F)c2cnc(OCC3CC(F)(F)C3)cn2)ccc1F	InChI=1S/C25H26F4N4O2S/c1-23(20-9-24(20,13-34-2)36-22(30)33-23)16-5-14(3-4-17(16)26)6-18(27)19-10-32-21(11-31-19)35-12-15-7-25(28,29)8-15/h3-6,10-11,15,20H,7-9,12-13H2,1-2H3,(H2,30,33)/b18-6-/t20-,23+,24+/m0/s1	NWIYSYRPQNHSKZ-QKQHWZHFSA-N	372871	US10246429, Example 278	Beta-secretase 2			 1320							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372871&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285445	402359806							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739757	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1[C@H]2COC[C@@H]1COC2)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C28H27F2N5O4S/c1-3-6-39-24-11-32-22(10-33-24)21(30)8-16-4-5-20(29)19(7-16)27(2)23-9-28(23,40-26(31)34-27)25(36)35-17-12-37-14-18(35)15-38-13-17/h1,4-5,7-8,10-11,17-18,23H,6,9,12-15H2,2H3,(H2,31,34)/b21-8-/t17?,18?,23-,27+,28-/m0/s1	NRIZDKUKBXCEHA-NVGNIVMCSA-N	372872	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)phenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((1R,5R)-3,7-dioxa-9-azabicyclo[3.3.1]nonan-9-yl)methanone::US10246429, Example 279	Beta-secretase 2			 176							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372872&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285430	402359807							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
739760	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CC[C@H](F)C1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C25H23F3N6O2S/c1-3-6-36-20-12-30-18(11-31-20)17(27)8-14-7-16(21(28)32-10-14)24(2)19-9-25(19,37-23(29)33-24)22(35)34-5-4-15(26)13-34/h1,7-8,10-12,15,19H,4-6,9,13H2,2H3,(H2,29,33)/b17-8-/t15-,19-,24+,25-/m0/s1	VIRFKBOLQBPCOG-TWMJARFMSA-N	372873	((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-yn-1-yloxy)pyrazin-2-yl)vinyl)pyridin-3-yl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)((S)-3-fluoropyrrolidin-1-yl)methanone::US10246429, Example 280	Beta-secretase 2			 119							US Patent		10.7270/Q23J3G8K			US10246429	Allen, JR; Amegadzie, A; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, CM; Siegmund, AC	Amgen Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=372873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=372873&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135285398	402359808							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722596	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(cs1)-c1cccc(c1)C#N	InChI=1S/C19H15N5S/c1-19(7-16-15(18(21)24-19)9-22-11-23-16)17-6-14(10-25-17)13-4-2-3-12(5-13)8-20/h2-6,9-11H,7H2,1H3,(H2,21,24)/t19-/m0/s1	NQLPDRCMTPRPMU-IBGZPJMESA-N	365377	US9868738, Example 1	Beta-secretase 2		>1000								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365377	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365377&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118958908	402362283							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722598	C[C@]1(Cc2ncncc2C(=N)N1)c1cccc(c1)-c1cccc(c1)C#N	InChI=1S/C21H17N5/c1-21(10-19-18(20(23)26-21)12-24-13-25-19)17-7-3-6-16(9-17)15-5-2-4-14(8-15)11-22/h2-9,12-13H,10H2,1H3,(H2,23,26)/t21-/m0/s1	YFONVDKDPDVRPD-NRFANRHFSA-N	365415	US9868738, Example 2	Beta-secretase 2		>1000								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365415	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365415&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974288	402362320							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722600	CC#Cc1cncc(c1)-c1cccc(c1)[C@]1(C)Cc2ncncc2C(=N)N1	InChI=1S/C22H19N5/c1-3-5-15-8-17(12-24-11-15)16-6-4-7-18(9-16)22(2)10-20-19(21(23)27-22)13-25-14-26-20/h4,6-9,11-14H,10H2,1-2H3,(H2,23,27)/t22-/m0/s1	YWXVAXXQRYOFMK-QFIPXVFZSA-N	365491	US9868738, Example 3	Beta-secretase 2		>1000								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365491	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365491&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974290	402362396							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722602	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(ccc1F)-c1cncc(Cl)c1	InChI=1S/C19H15ClFN5/c1-19(6-17-14(18(22)26-19)9-24-10-25-17)15-5-11(2-3-16(15)21)12-4-13(20)8-23-7-12/h2-5,7-10H,6H2,1H3,(H2,22,26)/t19-/m0/s1	YRRMYMSCRCEKQV-IBGZPJMESA-N	365533	US9868738, Example 4	Beta-secretase 2		 130								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365533&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974301	402362438							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722604	COc1cccc(c1)-c1ccc(F)c(c1)[C@]1(C)Cc2ncncc2C(=N)N1	InChI=1S/C21H19FN4O/c1-21(10-19-16(20(23)26-21)11-24-12-25-19)17-9-14(6-7-18(17)22)13-4-3-5-15(8-13)27-2/h3-9,11-12H,10H2,1-2H3,(H2,23,26)/t21-/m0/s1	PMJJSADEANPAHM-NRFANRHFSA-N	365569	US9868738, Example 5	Beta-secretase 2		 53.5								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365569&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974289	402362474							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722606	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(ccc1F)-c1cccc(c1)C(F)(F)F	InChI=1S/C21H16F4N4/c1-20(9-18-15(19(26)29-20)10-27-11-28-18)16-8-13(5-6-17(16)22)12-3-2-4-14(7-12)21(23,24)25/h2-8,10-11H,9H2,1H3,(H2,26,29)/t20-/m0/s1	NLWXRLJLVNYKLH-FQEVSTJZSA-N	365570	US9868738, Example 6	Beta-secretase 2		 549								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365570&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974578	402362475							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722608	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(ccc1F)-c1cncnc1	InChI=1S/C18H15FN6/c1-18(5-16-13(17(20)25-18)8-23-10-24-16)14-4-11(2-3-15(14)19)12-6-21-9-22-7-12/h2-4,6-10H,5H2,1H3,(H2,20,25)/t18-/m0/s1	HTGWWXVGZHXPDH-SFHVURJKSA-N	365571	US9868738, Example 7	Beta-secretase 2		 3455								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365571	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365571&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974586	402362476							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722610	COc1cncc(c1)-c1ccc(F)c(c1)[C@]1(C)Cc2ncncc2C(=N)N1	InChI=1S/C20H18FN5O/c1-20(7-18-15(19(22)26-20)10-24-11-25-18)16-6-12(3-4-17(16)21)13-5-14(27-2)9-23-8-13/h3-6,8-11H,7H2,1-2H3,(H2,22,26)/t20-/m0/s1	UQOFPICSIVXTIJ-FQEVSTJZSA-N	365572	US9868738, Example 8	Beta-secretase 2		 87.8								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365572&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974587	402362477							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722612	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(ccc1F)-c1cncc(c1)C#N	InChI=1S/C20H15FN6/c1-20(6-18-15(19(23)27-20)10-25-11-26-18)16-5-13(2-3-17(16)21)14-4-12(7-22)8-24-9-14/h2-5,8-11H,6H2,1H3,(H2,23,27)/t20-/m0/s1	NOOULKVXHSGPOE-FQEVSTJZSA-N	365573	US9868738, Example 9	Beta-secretase 2		 483								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365573&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974577	402362478							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722614	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(ccc1F)-c1cccnc1	InChI=1S/C19H16FN5/c1-19(8-17-14(18(21)25-19)10-23-11-24-17)15-7-12(4-5-16(15)20)13-3-2-6-22-9-13/h2-7,9-11H,8H2,1H3,(H2,21,25)/t19-/m0/s1	KPBXMEMNOCXNPW-IBGZPJMESA-N	365574	US9868738, Example 10	Beta-secretase 2		 1177								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365574	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365574&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974583	402362479							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722616	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(ccc1F)-c1cccc(c1)C#N	InChI=1S/C21H16FN5/c1-21(9-19-16(20(24)27-21)11-25-12-26-19)17-8-15(5-6-18(17)22)14-4-2-3-13(7-14)10-23/h2-8,11-12H,9H2,1H3,(H2,24,27)/t21-/m0/s1	RIEWDIMPGONAIX-NRFANRHFSA-N	365575	US9868738, Example 11	Beta-secretase 2		 259								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365575&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974590	402362480							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722618	CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(C)Cc2ncncc2C(=N)N1	InChI=1S/C22H18FN5/c1-3-4-14-7-16(11-25-10-14)15-5-6-19(23)18(8-15)22(2)9-20-17(21(24)28-22)12-26-13-27-20/h5-8,10-13H,9H2,1-2H3,(H2,24,28)/t22-/m0/s1	AKPFRQVIUQPXFU-QFIPXVFZSA-N	365576	US9868738, Example 12	Beta-secretase 2		 20.2								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365576	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365576&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974581	402362481							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722620	C[C@]1(Cc2ncncc2C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)C#N	InChI=1S/C19H14ClN5S/c1-19(7-15-13(18(22)25-19)9-23-10-24-15)17-14(20)6-16(26-17)12-4-2-3-11(5-12)8-21/h2-6,9-10H,7H2,1H3,(H2,22,25)/t19-/m0/s1	ZCYWICRGFKUFMK-IBGZPJMESA-N	365577	US9868738, Example 13	Beta-secretase 2		 15.1								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365577	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365577&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974589	402362482							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722622	C[C@]1(Cc2ncncc2C(=N)N1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C18H13ClN6S/c1-18(4-14-12(17(21)25-18)8-23-9-24-14)16-13(19)3-15(26-16)11-2-10(5-20)6-22-7-11/h2-3,6-9H,4H2,1H3,(H2,21,25)/t18-/m0/s1	CLERWLXJNBNPJF-SFHVURJKSA-N	365578	US9868738, Example 14	Beta-secretase 2		 31.6								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365578&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974579	402362483							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722624	C[C@]1(Cc2ncncc2C(=N)N1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C20H15ClN6OS/c1-20(7-15-13(18(22)26-20)8-23-9-24-15)17-14(21)6-16(29-17)11-3-2-4-12(5-11)19-27-25-10-28-19/h2-6,8-10H,7H2,1H3,(H2,22,26)/t20-/m0/s1	CYLWAHSUTKHAOZ-FQEVSTJZSA-N	365579	US9868738, Example 15	Beta-secretase 2		 37.3								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365579&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974576	402362484							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722626	C[C@]1(Cc2ncncc2C(=N)N1)c1sc(cc1Cl)-c1ccc(F)c(c1)C#N	InChI=1S/C19H13ClFN5S/c1-19(6-15-12(18(23)26-19)8-24-9-25-15)17-13(20)5-16(27-17)10-2-3-14(21)11(4-10)7-22/h2-5,8-9H,6H2,1H3,(H2,23,26)/t19-/m0/s1	ZDVHGIYXMDVSQX-IBGZPJMESA-N	365580	US9868738, Example 16	Beta-secretase 2		 16.7								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365580	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365580&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974588	402362485							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722628	C[C@]1(Cc2ncncc2C(=N)N1)c1sc(cc1Cl)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C20H14ClFN6OS/c1-20(6-15-13(18(23)27-20)7-24-8-25-15)17-14(21)5-16(30-17)10-2-11(4-12(22)3-10)19-28-26-9-29-19/h2-5,7-9H,6H2,1H3,(H2,23,27)/t20-/m0/s1	XNCUFGZJWRTEGY-FQEVSTJZSA-N	365581	US9868738, Example 17	Beta-secretase 2		 21.6								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365581	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365581&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974584	402362486							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722630	C[C@@]1(NC(=N)c2cncnc2C1(F)F)c1cc(cs1)-c1cccc(c1)C#N	InChI=1S/C19H13F2N5S/c1-18(19(20,21)16-14(17(23)26-18)8-24-10-25-16)15-6-13(9-27-15)12-4-2-3-11(5-12)7-22/h2-6,8-10H,1H3,(H2,23,26)/t18-/m1/s1	FGWIJLCCIOALDP-GOSISDBHSA-N	365582	US9868738, Example 18	Beta-secretase 2		 39.8								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365582	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365582&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974580	402362487							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722632	C[C@@]1(NC(=N)c2cncnc2C1(F)F)c1sc(cc1Cl)-c1cccc(c1)C#N	InChI=1S/C19H12ClF2N5S/c1-18(19(21,22)15-12(17(24)27-18)8-25-9-26-15)16-13(20)6-14(28-16)11-4-2-3-10(5-11)7-23/h2-6,8-9H,1H3,(H2,24,27)/t18-/m1/s1	OSEPKQZYTDNPCK-GOSISDBHSA-N	365583	US9868738, Example 19	Beta-secretase 2		 128								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365583	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365583&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974582	402362488							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722634	C[C@@]1(NC(=N)c2cncnc2C1(F)F)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C20H13ClF2N6OS/c1-19(20(22,23)15-12(17(24)28-19)7-25-8-26-15)16-13(21)6-14(31-16)10-3-2-4-11(5-10)18-29-27-9-30-18/h2-9H,1H3,(H2,24,28)/t19-/m1/s1	VZPHLMJKNSNKJV-LJQANCHMSA-N	365584	US9868738, Example 20	Beta-secretase 2		 118								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365584	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365584&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974585	402362489							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722636	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1cccc(c1)-c1cccc(c1)C#N	InChI=1S/C22H19N5/c1-14-25-13-19-20(26-14)11-22(2,27-21(19)24)18-8-4-7-17(10-18)16-6-3-5-15(9-16)12-23/h3-10,13H,11H2,1-2H3,(H2,24,27)/t22-/m0/s1	GIUNNRFRRLPJOB-QFIPXVFZSA-N	365585	US9868738, Example 21	Beta-secretase 2		>1000								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365585	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365585&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974614	402362490							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722638	CC#Cc1cncc(c1)-c1cccc(c1)[C@]1(C)Cc2nc(C)ncc2C(=N)N1	InChI=1S/C23H21N5/c1-4-6-16-9-18(13-25-12-16)17-7-5-8-19(10-17)23(3)11-21-20(22(24)28-23)14-26-15(2)27-21/h5,7-10,12-14H,11H2,1-3H3,(H2,24,28)/t23-/m0/s1	DYISBCMYKOHXMD-QHCPKHFHSA-N	365586	US9868738, Example 22	Beta-secretase 2		>1000								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365586&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974615	402362491							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722640	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1cc(cs1)-c1cccc(c1)C#N	InChI=1S/C20H17N5S/c1-12-23-10-16-17(24-12)8-20(2,25-19(16)22)18-7-15(11-26-18)14-5-3-4-13(6-14)9-21/h3-7,10-11H,8H2,1-2H3,(H2,22,25)/t20-/m0/s1	SLQZIXUGMPFPMQ-FQEVSTJZSA-N	365587	US9868738, Example 23	Beta-secretase 2		 87.9								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365587	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365587&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974564	402362492							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722642	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1sc(cc1Cl)-c1cccc(c1)C#N	InChI=1S/C20H16ClN5S/c1-11-24-10-14-16(25-11)8-20(2,26-19(14)23)18-15(21)7-17(27-18)13-5-3-4-12(6-13)9-22/h3-7,10H,8H2,1-2H3,(H2,23,26)/t20-/m0/s1	YCTOTTUXJUFUOS-FQEVSTJZSA-N	365588	US9868738, Example 24	Beta-secretase 2		 28.0								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365588	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365588&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974570	402362493							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722644	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C19H15ClN6S/c1-10-24-9-13-15(25-10)5-19(2,26-18(13)22)17-14(20)4-16(27-17)12-3-11(6-21)7-23-8-12/h3-4,7-9H,5H2,1-2H3,(H2,22,26)/t19-/m0/s1	NLALSSQJVRHLRO-IBGZPJMESA-N	365589	US9868738, Example 25	Beta-secretase 2		 62.4								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365589&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974566	402362494							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722646	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1sc(cc1Cl)-c1cccc(c1)-c1nnco1	InChI=1S/C21H17ClN6OS/c1-11-24-9-14-16(26-11)8-21(2,27-19(14)23)18-15(22)7-17(30-18)12-4-3-5-13(6-12)20-28-25-10-29-20/h3-7,9-10H,8H2,1-2H3,(H2,23,27)/t21-/m0/s1	VVAGRWMNTRXMTL-NRFANRHFSA-N	365590	US9868738, Example 26	Beta-secretase 2		 29.1								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365590	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365590&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974562	402362495							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722648	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1sc(cc1Cl)-c1ccc(F)c(c1)C#N	InChI=1S/C20H15ClFN5S/c1-10-25-9-13-16(26-10)7-20(2,27-19(13)24)18-14(21)6-17(28-18)11-3-4-15(22)12(5-11)8-23/h3-6,9H,7H2,1-2H3,(H2,24,27)/t20-/m0/s1	PMYYRWIFLAFLNY-FQEVSTJZSA-N	365591	US9868738, Example 27	Beta-secretase 2		 28.3								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365591&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974295	402362496							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722650	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1sc(cc1Cl)-c1cc(F)cc(c1)-c1nnco1	InChI=1S/C21H16ClFN6OS/c1-10-25-8-14-16(27-10)7-21(2,28-19(14)24)18-15(22)6-17(31-18)11-3-12(5-13(23)4-11)20-29-26-9-30-20/h3-6,8-9H,7H2,1-2H3,(H2,24,28)/t21-/m0/s1	NWZNGWLSGIKSDF-NRFANRHFSA-N	365592	US9868738, Example 28	Beta-secretase 2		 24.4								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365592	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365592&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974302	402362497							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722652	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1sc(cc1Cl)-c1cccc(c1)-c1ncno1	InChI=1S/C21H17ClN6OS/c1-11-24-9-14-16(27-11)8-21(2,28-19(14)23)18-15(22)7-17(30-18)12-4-3-5-13(6-12)20-25-10-26-29-20/h3-7,9-10H,8H2,1-2H3,(H2,23,28)/t21-/m0/s1	VRRDREALBYMNLJ-NRFANRHFSA-N	365593	US9868738, Example 29	Beta-secretase 2		 79.7								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365593	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365593&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974296	402362498							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722654	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1cccc(c1)-c1cccc(c1)C#N	InChI=1S/C24H21N5/c1-24(12-21-20(22(26)29-24)14-27-23(28-21)16-8-9-16)19-7-3-6-18(11-19)17-5-2-4-15(10-17)13-25/h2-7,10-11,14,16H,8-9,12H2,1H3,(H2,26,29)/t24-/m0/s1	TXSYKBPKEBSMNC-DEOSSOPVSA-N	365594	US9868738, Example 30	Beta-secretase 2		>1000								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365594	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365594&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974291	402362499							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722656	CC#Cc1cncc(c1)-c1cccc(c1)[C@]1(C)Cc2nc(ncc2C(=N)N1)C1CC1	InChI=1S/C25H23N5/c1-3-5-16-10-19(14-27-13-16)18-6-4-7-20(11-18)25(2)12-22-21(23(26)30-25)15-28-24(29-22)17-8-9-17/h4,6-7,10-11,13-15,17H,8-9,12H2,1-2H3,(H2,26,30)/t25-/m0/s1	WNAPKYYDQNEURL-VWLOTQADSA-N	365595	US9868738, Example 31	Beta-secretase 2		>1000								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365595	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365595&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974297	402362500							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722658	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1cc(cs1)-c1cccc(c1)C#N	InChI=1S/C22H19N5S/c1-22(19-8-16(12-28-19)15-4-2-3-13(7-15)10-23)9-18-17(20(24)27-22)11-25-21(26-18)14-5-6-14/h2-4,7-8,11-12,14H,5-6,9H2,1H3,(H2,24,27)/t22-/m0/s1	LMBVCDFFMJGDCH-QFIPXVFZSA-N	365596	US9868738, Example 32	Beta-secretase 2		 65.6								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365596&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974286	402362501							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722660	COc1cccc2cc([nH]c12)-c1csc(c1)[C@]1(C)Cc2nc(ncc2C(=N)N1)C1CC1			365597	US9868738, Example 33	Beta-secretase 2		 4.80								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365597	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365597&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974298	402362502							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722662	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1cc(cs1)-c1cccc(c1)-c1nnco1	InChI=1S/C23H20N6OS/c1-23(9-18-17(20(24)28-23)10-25-21(27-18)13-5-6-13)19-8-16(11-31-19)14-3-2-4-15(7-14)22-29-26-12-30-22/h2-4,7-8,10-13H,5-6,9H2,1H3,(H2,24,28)/t23-/m0/s1	LTQVPMLCNOGJQO-QHCPKHFHSA-N	365598	US9868738, Example 34	Beta-secretase 2		 215								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365598&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974292	402362503							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722664	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1cc(cs1)-c1cncc(c1)C#N	InChI=1S/C21H18N6S/c1-21(18-5-15(11-28-18)14-4-12(7-22)8-24-9-14)6-17-16(19(23)27-21)10-25-20(26-17)13-2-3-13/h4-5,8-11,13H,2-3,6H2,1H3,(H2,23,27)/t21-/m0/s1	BARATIJUMCGCHN-NRFANRHFSA-N	365599	US9868738, Example 35	Beta-secretase 2		 142								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365599&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974593	402362504							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722666	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1sc(cc1Cl)-c1cccc(c1)C#N	InChI=1S/C22H18ClN5S/c1-22(9-17-15(20(25)28-22)11-26-21(27-17)13-5-6-13)19-16(23)8-18(29-19)14-4-2-3-12(7-14)10-24/h2-4,7-8,11,13H,5-6,9H2,1H3,(H2,25,28)/t22-/m0/s1	VNAFEFHQFNPWRI-QFIPXVFZSA-N	365600	US9868738, Example 36	Beta-secretase 2		 21.5								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365600&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974598	402362505							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722668	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1sc(cc1Cl)-c1cncc(c1)C#N	InChI=1S/C21H17ClN6S/c1-21(6-16-14(19(24)28-21)10-26-20(27-16)12-2-3-12)18-15(22)5-17(29-18)13-4-11(7-23)8-25-9-13/h4-5,8-10,12H,2-3,6H2,1H3,(H2,24,28)/t21-/m0/s1	WQJVSFCBYZGCDS-NRFANRHFSA-N	365601	US9868738, Example 37	Beta-secretase 2		 44.2								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365601&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974597	402362506							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722670	COc1cccc2cc([nH]c12)-c1cc(Cl)c(s1)[C@]1(C)Cc2nc(ncc2C(=N)N1)C1CC1			365602	US9868738, Example 38	Beta-secretase 2		 2.00								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365602&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974601	402362507							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722672	COc1cccc2cc([nH]c12)-c1csc(c1)[C@]1(C)Cc2nc(ncc2C(=N)N1)C(F)(F)F			365603	US9868738, Example 39	Beta-secretase 2		 1.50								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365603&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974621	402362508							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722674	C[C@]1(Cc2nc(ncc2C(=N)N1)C(F)(F)F)c1cc(cs1)-c1cccc(c1)C#N	InChI=1S/C20H14F3N5S/c1-19(16-6-13(10-29-16)12-4-2-3-11(5-12)8-24)7-15-14(17(25)28-19)9-26-18(27-15)20(21,22)23/h2-6,9-10H,7H2,1H3,(H2,25,28)/t19-/m0/s1	GHFPUAFTSKQYTD-IBGZPJMESA-N	365604	US9868738, Example 40	Beta-secretase 2		 23.1								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365604&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974616	402362509							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722676	C[C@]1(Cc2nc(ncc2C(=N)N1)C(F)(F)F)c1cc(cs1)-c1cncc(c1)C#N	InChI=1S/C19H13F3N6S/c1-18(15-3-12(9-29-15)11-2-10(5-23)6-25-7-11)4-14-13(16(24)28-18)8-26-17(27-14)19(20,21)22/h2-3,6-9H,4H2,1H3,(H2,24,28)/t18-/m0/s1	WIKWDOXQOJBAKW-SFHVURJKSA-N	365605	US9868738, Example 41	Beta-secretase 2		 97.7								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365605&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974625	402362510							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722678	C[C@]1(Cc2nc(ncc2C(=N)N1)C(F)(F)F)c1cc(cs1)-c1cccc(c1)-c1nnco1	InChI=1S/C21H15F3N6OS/c1-20(7-15-14(17(25)29-20)8-26-19(28-15)21(22,23)24)16-6-13(9-32-16)11-3-2-4-12(5-11)18-30-27-10-31-18/h2-6,8-10H,7H2,1H3,(H2,25,29)/t20-/m0/s1	YNYMGCDPSKCFLX-FQEVSTJZSA-N	365606	US9868738, Example 42	Beta-secretase 2		 121								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365606	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365606&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974617	402362511							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722680	C[C@]1(Cc2ncncc2C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H16F2N6O/c1-20(7-17-13(18(23)28-20)9-24-10-26-17)14-6-12(3-4-15(14)22)27-19(29)16-5-2-11(21)8-25-16/h2-6,8-10H,7H2,1H3,(H2,23,28)(H,27,29)/t20-/m0/s1	BRCYVPIMBJJFFF-FQEVSTJZSA-N	365607	US9868738, Example 43	Beta-secretase 2		 3.00								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365607&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118958876	402362512							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722682	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C21H18F2N6O/c1-11-25-10-14-18(27-11)8-21(2,29-19(14)24)15-7-13(4-5-16(15)23)28-20(30)17-6-3-12(22)9-26-17/h3-7,9-10H,8H2,1-2H3,(H2,24,29)(H,28,30)/t21-/m0/s1	IZQZMAIUEUQWQB-NRFANRHFSA-N	365608	US9868738, Example 44	Beta-secretase 2		 4.50								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365608&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974575	402362513							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722684	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H18ClFN6O/c1-11-25-10-14-18(27-11)8-21(2,29-19(14)24)15-7-13(4-5-16(15)23)28-20(30)17-6-3-12(22)9-26-17/h3-7,9-10H,8H2,1-2H3,(H2,24,29)(H,28,30)/t21-/m0/s1	BSODCMDQTYPPST-NRFANRHFSA-N	365609	US9868738, Example 45	Beta-secretase 2		 4.20								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365609&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974573	402362514							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722686	Cc1ncc2C(=N)N[C@@](C)(Cc2n1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C22H18F4N6O/c1-11-28-10-14-18(30-11)8-21(2,32-19(14)27)15-7-13(4-5-16(15)23)31-20(33)17-6-3-12(9-29-17)22(24,25)26/h3-7,9-10H,8H2,1-2H3,(H2,27,32)(H,31,33)/t21-/m0/s1	ZPVMNKWWOLVDIJ-NRFANRHFSA-N	365610	US9868738, Example 46	Beta-secretase 2		 48.3								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365610&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974574	402362515							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722688	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)Cc2nc(C)ncc2C(=N)N1	InChI=1S/C22H21FN6O2/c1-12-25-11-15-19(27-12)9-22(2,29-20(15)24)16-8-13(4-6-17(16)23)28-21(30)18-7-5-14(31-3)10-26-18/h4-8,10-11H,9H2,1-3H3,(H2,24,29)(H,28,30)/t22-/m0/s1	RYNQXOFNKMCIHH-QFIPXVFZSA-N	365611	US9868738, Example 47	Beta-secretase 2		 15.3								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365611&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974572	402362516							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722690	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C23H20F2N6O/c1-23(9-19-15(20(26)31-23)11-28-21(30-19)12-2-3-12)16-8-14(5-6-17(16)25)29-22(32)18-7-4-13(24)10-27-18/h4-8,10-12H,2-3,9H2,1H3,(H2,26,31)(H,29,32)/t23-/m0/s1	SRAHWVQYJCESBV-QHCPKHFHSA-N	365612	US9868738, Example 48	Beta-secretase 2		 3.00								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365612&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974299	402362517							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722692	C[C@]1(Cc2nc(ncc2C(=N)N1)C1CC1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C24H20F4N6O/c1-23(9-19-15(20(29)34-23)11-31-21(33-19)12-2-3-12)16-8-14(5-6-17(16)25)32-22(35)18-7-4-13(10-30-18)24(26,27)28/h4-8,10-12H,2-3,9H2,1H3,(H2,29,34)(H,32,35)/t23-/m0/s1	XRNPZCMGRHPPMX-QHCPKHFHSA-N	365613	US9868738, Example 49	Beta-secretase 2		 34.2								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365613&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974303	402362518							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722694	Cc1ncc2C(=N)N[C@](Cc2n1)(C(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H16F3N7O/c1-11-28-10-14-18(30-11)7-22(21(24)25,32-19(14)27)15-6-13(3-4-16(15)23)31-20(33)17-5-2-12(8-26)9-29-17/h2-6,9-10,21H,7H2,1H3,(H2,27,32)(H,31,33)/t22-/m0/s1	WASFOMPLLYPXNY-QFIPXVFZSA-N	365614	US9868738, Example 50	Beta-secretase 2		 10.9								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365614&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974300	402362519							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
722696	C[C@]1(Cc2nccnc2C(=N)N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H16FN7O/c1-21(9-17-18(19(24)29-21)26-7-6-25-17)14-8-13(3-4-15(14)22)28-20(30)16-5-2-12(10-23)11-27-16/h2-8,11H,9H2,1H3,(H2,24,29)(H,28,30)/t21-/m0/s1	MOKMVNJIQFEFGZ-NRFANRHFSA-N	365615	US9868738, Example 51	Beta-secretase 2		 207								US Patent		10.7270/Q24T6MPT		aid1797991	US9868738	Liu, K; He, S; Cumming, JN; Stamford, AW	Merck Sharp & Dohme Corp	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=365615	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=365615&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974304	402362520							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827882	NC1=N[C@]2(CO[C@@H](CF)C[C@H]2CS1)c1cc(CNCC(F)(F)F)c(F)cc1F	InChI=1S/C17H19F6N3OS/c18-4-11-2-10-6-28-15(24)26-16(10,8-27-11)12-1-9(13(19)3-14(12)20)5-25-7-17(21,22)23/h1,3,10-11,25H,2,4-8H2,(H2,24,26)/t10-,11+,16-/m0/s1	KXRWMDHPUURSND-USBNGQNGSA-N	160666	US9045498, 8	Beta-secretase 2			 295							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=160666	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=160666&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	74B	5T1W	86762648	295369482							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827883	C[C@@H]1C[C@](C)(N=C(N)S1)c1cc(CNC2(CC2)C(F)(F)F)c(F)cc1F	InChI=1S/C17H20F5N3S/c1-9-7-15(2,25-14(23)26-9)11-5-10(12(18)6-13(11)19)8-24-16(3-4-16)17(20,21)22/h5-6,9,24H,3-4,7-8H2,1-2H3,(H2,23,25)/t9-,15+/m1/s1	ZQULGQNNJUBPOZ-PSLIRLAXSA-N	50259962	CHEMBL4088234	Beta-secretase 2			 228							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259962&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	P6M	5TFU	123132915	404339858							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827884	C[C@]1(CCSC(N)=N1)c1cc(CNC2(CC2)C(F)(F)F)c(F)cc1F	InChI=1S/C16H18F5N3S/c1-14(4-5-25-13(22)24-14)10-6-9(11(17)7-12(10)18)8-23-15(2-3-15)16(19,20)21/h6-7,23H,2-5,8H2,1H3,(H2,22,24)/t14-/m0/s1	XKONRMXLBXCJAM-AWEZNQCLSA-N	50259973	CHEMBL4098403	Beta-secretase 2			 405							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259973&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	P6U	5T1U,5TFT	123132907	404339868							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827885	C[C@]1(CCSC(N)=N1)c1cc(CNC2(CC2)C#N)c(F)cc1F	InChI=1S/C16H18F2N4S/c1-15(4-5-23-14(20)22-15)11-6-10(12(17)7-13(11)18)8-21-16(9-19)2-3-16/h6-7,21H,2-5,8H2,1H3,(H2,20,22)/t15-/m0/s1	YHJPABZBDBCJQX-HNNXBMFYSA-N	50259960	CHEMBL4077211	Beta-secretase 2			 11500							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259960&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137651451	404339856							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827886	C[C@]1(CCSC(N)=N1)c1cc(CNC2(CC2)C(F)F)c(F)cc1F	InChI=1S/C16H19F4N3S/c1-15(4-5-24-14(21)23-15)10-6-9(11(17)7-12(10)18)8-22-16(2-3-16)13(19)20/h6-7,13,22H,2-5,8H2,1H3,(H2,21,23)/t15-/m0/s1	BZFHYEXJWOLTQN-HNNXBMFYSA-N	50259959	CHEMBL4062728	Beta-secretase 2			 1010							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259959&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137634377	404339855							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827887	C[C@]1(CCSC(N)=N1)c1cc(CNC2CC2)c(F)cc1F	InChI=1S/C15H19F2N3S/c1-15(4-5-21-14(18)20-15)11-6-9(8-19-10-2-3-10)12(16)7-13(11)17/h6-7,10,19H,2-5,8H2,1H3,(H2,18,20)/t15-/m0/s1	ORANLJDZFUCKMO-HNNXBMFYSA-N	50259957	CHEMBL4085715	Beta-secretase 2			>100000							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259957&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137641491	404339854							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827888	C[C@]1(CCSC(N)=N1)c1cc(CNCCC(F)(F)F)c(F)cc1F	InChI=1S/C15H18F5N3S/c1-14(3-5-24-13(21)23-14)10-6-9(11(16)7-12(10)17)8-22-4-2-15(18,19)20/h6-7,22H,2-5,8H2,1H3,(H2,21,23)/t14-/m0/s1	DCYWNJDSKJXMKI-AWEZNQCLSA-N	50259955	CHEMBL4084170	Beta-secretase 2			>100000							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259955&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137646316	404339853							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827893	C[C@@H](NCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1)C(F)(F)F	InChI=1S/C15H18F5N3S/c1-8(15(18,19)20)22-7-9-5-10(12(17)6-11(9)16)14(2)3-4-24-13(21)23-14/h5-6,8,22H,3-4,7H2,1-2H3,(H2,21,23)/t8-,14+/m1/s1	STUTWXRFWQRASH-CLAHSXSESA-N	50259970	CHEMBL4061602	Beta-secretase 2			 7130							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259970&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137635011	404339866							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827894	C[C@]1(CCSC(N)=N1)c1cc(CNCC(F)F)c(F)cc1F	InChI=1S/C14H17F4N3S/c1-14(2-3-22-13(19)21-14)9-4-8(6-20-7-12(17)18)10(15)5-11(9)16/h4-5,12,20H,2-3,6-7H2,1H3,(H2,19,21)/t14-/m0/s1	FYKSUJGCXDMRJR-AWEZNQCLSA-N	50259950	CHEMBL4066885	Beta-secretase 2			 27300							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259950&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137633017	104109945						ZINC40408213	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827895	C[C@]1(CCSC(N)=N1)c1cc(CNCC(F)(F)F)c(F)cc1F	InChI=1S/C14H16F5N3S/c1-13(2-3-23-12(20)22-13)9-4-8(10(15)5-11(9)16)6-21-7-14(17,18)19/h4-5,21H,2-3,6-7H2,1H3,(H2,20,22)/t13-/m0/s1	OAANHBKIQRWYQJ-ZDUSSCGKSA-N	50259949	CHEMBL4086633	Beta-secretase 2			 7600							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259949&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137643369	404339851							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827897	CN(Cc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1)CC(F)(F)F	InChI=1S/C15H18F5N3S/c1-14(3-4-24-13(21)22-14)10-5-9(11(16)6-12(10)17)7-23(2)8-15(18,19)20/h5-6H,3-4,7-8H2,1-2H3,(H2,21,22)/t14-/m0/s1	RHXHFXVYZBDQQN-AWEZNQCLSA-N	50259969	CHEMBL4104527	Beta-secretase 2			>84000							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259969&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137657646	404339865							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827898	COC[C@@H](C)NCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1	InChI=1S/C16H23F2N3OS/c1-10(9-22-3)20-8-11-6-12(14(18)7-13(11)17)16(2)4-5-23-15(19)21-16/h6-7,10,20H,4-5,8-9H2,1-3H3,(H2,19,21)/t10-,16+/m1/s1	HKFFPSFZJNYNQZ-HWPZZCPQSA-N	50259968	CHEMBL4084653	Beta-secretase 2			 19400							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259968&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137646126	404339864							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827901	COCCCNCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1	InChI=1S/C16H23F2N3OS/c1-16(4-7-23-15(19)21-16)12-8-11(13(17)9-14(12)18)10-20-5-3-6-22-2/h8-9,20H,3-7,10H2,1-2H3,(H2,19,21)/t16-/m0/s1	GRUDLDUJVATURL-INIZCTEOSA-N	50259967	CHEMBL4064708	Beta-secretase 2			 62900							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259967&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137635828	404339863							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827902	CO[C@@H]1CCN(Cc2cc(c(F)cc2F)[C@]2(C)CCSC(N)=N2)C1	InChI=1S/C17H23F2N3OS/c1-17(4-6-24-16(20)21-17)13-7-11(14(18)8-15(13)19)9-22-5-3-12(10-22)23-2/h7-8,12H,3-6,9-10H2,1-2H3,(H2,20,21)/t12-,17+/m1/s1	FSKVGYAMIKBJFU-PXAZEXFGSA-N	50259975	CHEMBL4073296	Beta-secretase 2			>100000							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259975&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137640486	404339870							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827903	CN(C)Cc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1	InChI=1S/C14H19F2N3S/c1-14(4-5-20-13(17)18-14)10-6-9(8-19(2)3)11(15)7-12(10)16/h6-7H,4-5,8H2,1-3H3,(H2,17,18)/t14-/m0/s1	COYGMPIGIAMZNG-AWEZNQCLSA-N	50259965	CHEMBL4100140	Beta-secretase 2			>100000							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259965&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137662127	404339861							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827904	CC(C)NCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1	InChI=1S/C15H21F2N3S/c1-9(2)19-8-10-6-11(13(17)7-12(10)16)15(3)4-5-21-14(18)20-15/h6-7,9,19H,4-5,8H2,1-3H3,(H2,18,20)/t15-/m0/s1	SLAATTPDVKCXEQ-HNNXBMFYSA-N	50259964	CHEMBL4083698	Beta-secretase 2			>94000							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259964&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137648425	404339860							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827906	Cc1ccc(NCc2cc(c(F)cc2F)[C@]2(C)CCSC(N)=N2)nc1	InChI=1S/C18H20F2N4S/c1-11-3-4-16(22-9-11)23-10-12-7-13(15(20)8-14(12)19)18(2)5-6-25-17(21)24-18/h3-4,7-9H,5-6,10H2,1-2H3,(H2,21,24)(H,22,23)/t18-/m0/s1	ZZYSRRFOAYTMKM-SFHVURJKSA-N	50259976	CHEMBL4091480	Beta-secretase 2			>100000							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259976&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137654633	404339871							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827941	C[C@]1(CCSC(N)=N1)c1cc(CNC2(COC2)C(F)(F)F)c(F)cc1F	InChI=1S/C16H18F5N3OS/c1-14(2-3-26-13(22)24-14)10-4-9(11(17)5-12(10)18)6-23-15(7-25-8-15)16(19,20)21/h4-5,23H,2-3,6-8H2,1H3,(H2,22,24)/t14-/m0/s1	QAKZCMKEOGZLLP-AWEZNQCLSA-N	50259961	CHEMBL4080380	Beta-secretase 2			 1890							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259961&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137645221	404339857							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827942	C[C@]1(CCSC(N)=N1)c1cc(CNCC2CC2)c(F)cc1F	InChI=1S/C16H21F2N3S/c1-16(4-5-22-15(19)21-16)12-6-11(13(17)7-14(12)18)9-20-8-10-2-3-10/h6-7,10,20H,2-5,8-9H2,1H3,(H2,19,21)/t16-/m0/s1	YWBPXKGASACQGY-INIZCTEOSA-N	50259971	CHEMBL4064148	Beta-secretase 2			 35900							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259971&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137637375	404339867							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827945	CC(C)(NCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1)C(F)(F)F	InChI=1S/C16H20F5N3S/c1-14(2,16(19,20)21)23-8-9-6-10(12(18)7-11(9)17)15(3)4-5-25-13(22)24-15/h6-7,23H,4-5,8H2,1-3H3,(H2,22,24)/t15-/m0/s1	JMOHXAUCSPMQGB-HNNXBMFYSA-N	50259954	CHEMBL4094377	Beta-secretase 2			 1020							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259954&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137653545	404339852							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827946	C[C@]1(CCSC(N)=N1)c1cc(CNC23CC(C2)C3)c(F)cc1F	InChI=1S/C17H21F2N3S/c1-16(2-3-23-15(20)22-16)12-4-11(13(18)5-14(12)19)9-21-17-6-10(7-17)8-17/h4-5,10,21H,2-3,6-9H2,1H3,(H2,20,22)/t10?,16-,17?/m0/s1	TYGINIZGIMDBFT-KJWVSFLRSA-N	50259974	CHEMBL4102593	Beta-secretase 2			 17500							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259974&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137656577	404339869							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827947	COCCNCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1	InChI=1S/C15H21F2N3OS/c1-15(3-6-22-14(18)20-15)11-7-10(9-19-4-5-21-2)12(16)8-13(11)17/h7-8,19H,3-6,9H2,1-2H3,(H2,18,20)/t15-/m0/s1	MWGLFDPAWCGVCN-HNNXBMFYSA-N	50259966	CHEMBL4092406	Beta-secretase 2			 26800							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259966&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137652983	404339862							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50827951	CCNCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1	InChI=1S/C14H19F2N3S/c1-3-18-8-9-6-10(12(16)7-11(9)15)14(2)4-5-20-13(17)19-14/h6-7,18H,3-5,8H2,1-2H3,(H2,17,19)/t14-/m0/s1	PKEKOGWSIXFEBA-AWEZNQCLSA-N	50259963	CHEMBL4061944	Beta-secretase 2			 75700							ChEMBL	10.1021/acs.jmedchem.6b01451	10.7270/Q2154KHX	27997172			Butler, CR; Ogilvie, K; Martinez-Alsina, L; Barreiro, G; Beck, EM; Nolan, CE; Atchison, K; Benvenuti, E; Buzon, L; Doran, S; Gonzales, C; Helal, CJ; Hou, X; Hsu, MH; Johnson, EF; Lapham, K; Lanyon, L; Parris, K; O'Neill, BT; Riddell, D; Robshaw, A; Vajdos, F; Brodney, MA	The Scripps Research Institute	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259963&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137637780	404339859							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50908962	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F	InChI=1S/C19H18ClF2N5O3S/c1-27-18(23)26-19(6-2-3-15(19)31(27,29)30)12-8-11(4-5-13(12)21)25-17(28)16-14(22)7-10(20)9-24-16/h4-5,7-9,15H,2-3,6H2,1H3,(H2,23,26)(H,25,28)/t15-,19-/m1/s1	GYVDXWKQHSKJCJ-DNVCBOLYSA-N	50271163	CHEMBL4129654	Beta-secretase 2		 1.000000								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271163&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201660	405255740							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50908963	COc1cnc2c(nccc2c1)C(=O)Nc1ccc(F)c(c1)[C@]12CCC[C@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C23H23FN6O4S/c1-30-22(25)29-23(8-3-4-18(23)35(30,32)33)16-11-14(5-6-17(16)24)28-21(31)20-19-13(7-9-26-20)10-15(34-2)12-27-19/h5-7,9-12,18H,3-4,8H2,1-2H3,(H2,25,29)(H,28,31)/t18-,23-/m1/s1	YRLMAKOEMOXAHN-WZONZLPQSA-N	50271164	CHEMBL4128525	Beta-secretase 2		 10.0								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271164&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			145962834	405255741							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50908968	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2nccc3cc(Br)cnc23)ccc1F	InChI=1S/C22H20BrFN6O3S/c1-30-21(25)29-22(7-2-3-17(22)34(30,32)33)15-10-14(4-5-16(15)24)28-20(31)19-18-12(6-8-26-19)9-13(23)11-27-18/h4-6,8-11,17H,2-3,7H2,1H3,(H2,25,29)(H,28,31)/t17-,22-/m1/s1	WFTGZFLRKOTOMZ-VGOFRKELSA-N	50271165	CHEMBL4128375	Beta-secretase 2		 0.500000								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271165&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			145961539	405255742							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50908985	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C20H20F3N5O4S/c1-28-19(24)27-20(8-2-3-16(20)33(28,30)31)13-9-11(4-6-14(13)21)26-17(29)15-7-5-12(10-25-15)32-18(22)23/h4-7,9-10,16,18H,2-3,8H2,1H3,(H2,24,27)(H,26,29)/t16-,20-/m1/s1	KUEMKDZBSBUMIV-OXQOHEQNSA-N	50271166	CHEMBL4130055	Beta-secretase 2		 6.0								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271166&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202050	405255743							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50908986	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H19ClFN5O3S/c1-26-18(22)25-19(8-2-3-16(19)30(26,28)29)13-9-12(5-6-14(13)21)24-17(27)15-7-4-11(20)10-23-15/h4-7,9-10,16H,2-3,8H2,1H3,(H2,22,25)(H,24,27)/t16-,19-/m1/s1	SFRFSUMBDAYLDH-VQIMIIECSA-N	50271172	CHEMBL4127711	Beta-secretase 2		 1.000000								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271172&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202062	405255749							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50908987	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H19FN6O3S/c1-27-19(23)26-20(8-2-3-17(20)31(27,29)30)14-9-13(5-6-15(14)21)25-18(28)16-7-4-12(10-22)11-24-16/h4-7,9,11,17H,2-3,8H2,1H3,(H2,23,26)(H,25,28)/t17-,20-/m1/s1	YIYHJEBMLKIUPV-YLJYHZDGSA-N	50271173	CHEMBL4129113	Beta-secretase 2		 3.0								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271173&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202069	405255750							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909015	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(C)cn2)ccc1F	InChI=1S/C19H21FN6O3S/c1-11-9-23-15(10-22-11)17(27)24-12-5-6-14(20)13(8-12)19-7-3-4-16(19)30(28,29)26(2)18(21)25-19/h5-6,8-10,16H,3-4,7H2,1-2H3,(H2,21,25)(H,24,27)/t16-,19-/m1/s1	TZNJQQFHTFHSBF-VQIMIIECSA-N	50271174	CHEMBL4126480	Beta-secretase 2		 16								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271174&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201653	405255751							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909042	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(C)cn2)ccc1F	InChI=1S/C20H22FN5O3S/c1-12-5-8-16(23-11-12)18(27)24-13-6-7-15(21)14(10-13)20-9-3-4-17(20)30(28,29)26(2)19(22)25-20/h5-8,10-11,17H,3-4,9H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20-/m1/s1	PEGNNDOQUVAZJH-YLJYHZDGSA-N	50271167	CHEMBL4127870	Beta-secretase 2		 3.0								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271167&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201655	405255744							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909043	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(F)cc2F)ccc1F	InChI=1S/C19H18F3N5O3S/c1-27-18(23)26-19(6-2-3-15(19)31(27,29)30)12-8-11(4-5-13(12)21)25-17(28)16-14(22)7-10(20)9-24-16/h4-5,7-9,15H,2-3,6H2,1H3,(H2,23,26)(H,25,28)/t15-,19-/m1/s1	NWDPGGJFZUSNSI-DNVCBOLYSA-N	50271175	CHEMBL4126365	Beta-secretase 2		 1.000000								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271175&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202063	405255752							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909060	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(F)cc2C)ccc1F	InChI=1S/C20H21F2N5O3S/c1-11-8-12(21)10-24-17(11)18(28)25-13-5-6-15(22)14(9-13)20-7-3-4-16(20)31(29,30)27(2)19(23)26-20/h5-6,8-10,16H,3-4,7H2,1-2H3,(H2,23,26)(H,25,28)/t16-,20-/m1/s1	WJPNPTZJGPWLCP-OXQOHEQNSA-N	50271168	CHEMBL4127283	Beta-secretase 2		 1.000000								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271168&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202057	405255745							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909062	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]23CCC[C@H]2S(=O)(=O)N(C)C(=N)N3)c(C)n1	InChI=1S/C20H23FN6O4S/c1-11-17(23-10-16(24-11)31-3)18(28)25-12-6-7-14(21)13(9-12)20-8-4-5-15(20)32(29,30)27(2)19(22)26-20/h6-7,9-10,15H,4-5,8H2,1-3H3,(H2,22,26)(H,25,28)/t15-,20-/m1/s1	YDAUYASJAKMRQF-FOIQADDNSA-N	50271171	CHEMBL4125904	Beta-secretase 2		 6.0								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271171&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202106	405255748							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909065	COc1cnc2c(nccc2n1)C(=O)Nc1ccc(F)c(c1)[C@]12CCC[C@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C22H22FN7O4S/c1-30-21(24)29-22(8-3-4-16(22)35(30,32)33)13-10-12(5-6-14(13)23)27-20(31)19-18-15(7-9-25-19)28-17(34-2)11-26-18/h5-7,9-11,16H,3-4,8H2,1-2H3,(H2,24,29)(H,27,31)/t16-,22-/m1/s1	JTJRCLLMZWXZNJ-OPAMFIHVSA-N	50271170	CHEMBL4127138	Beta-secretase 2		 9.0								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271170&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			145962778	405255747							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
50909066	COc1cnc2c(ccnc2c1)C(=O)Nc1ccc(F)c(c1)[C@]12CCC[C@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C23H23FN6O4S/c1-30-22(25)29-23(8-3-4-19(23)35(30,32)33)16-10-13(5-6-17(16)24)28-21(31)15-7-9-26-18-11-14(34-2)12-27-20(15)18/h5-7,9-12,19H,3-4,8H2,1-2H3,(H2,25,29)(H,28,31)/t19-,23-/m1/s1	FNDYCIVFOCBPAD-AUSIDOKSSA-N	50271169	CHEMBL4129747	Beta-secretase 2		 198								ChEMBL	10.1021/acsmedchemlett.7b00268	10.7270/Q2K93B1Q	28835787			Blass, B	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271169&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			145960757	405255746							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804459	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H19F2N5O3S/c1-26-18(22)25-19(8-2-3-16(19)30(26,28)29)13-9-12(5-6-14(13)21)24-17(27)15-7-4-11(20)10-23-15/h4-7,9-10,16H,2-3,8H2,1H3,(H2,22,25)(H,24,27)/t16-,19-/m1/s1	HXAHDCZFPUFUOS-VQIMIIECSA-N	402345	US10329291, Example 1	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402345	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402345&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201936	405262335							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804461	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(OCCF)cn2)ccc1F	InChI=1S/C20H22F2N6O4S/c1-28-19(23)27-20(6-2-3-16(20)33(28,30)31)13-9-12(4-5-14(13)22)26-18(29)15-10-25-17(11-24-15)32-8-7-21/h4-5,9-11,16H,2-3,6-8H2,1H3,(H2,23,27)(H,26,29)/t16-,20-/m1/s1	TUDUEFUAQZKIDM-OXQOHEQNSA-N	402346	US10329291, Example 2	Beta-secretase 2		 28.0								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402346	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402346&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202066	405262336							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804463	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C20H20F3N5O4S/c1-28-19(24)27-20(8-2-3-16(20)33(28,30)31)13-9-11(4-6-14(13)21)26-17(29)15-7-5-12(10-25-15)32-18(22)23/h4-7,9-10,16,18H,2-3,8H2,1H3,(H2,24,27)(H,26,29)/t16-,20-/m1/s1	KUEMKDZBSBUMIV-OXQOHEQNSA-N	50271166	CHEMBL4130055	Beta-secretase 2		 6.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271166&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202050	405255743							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804465	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H19ClFN5O3S/c1-26-18(22)25-19(8-2-3-16(19)30(26,28)29)13-9-12(5-6-14(13)21)24-17(27)15-7-4-11(20)10-23-15/h4-7,9-10,16H,2-3,8H2,1H3,(H2,22,25)(H,24,27)/t16-,19-/m1/s1	SFRFSUMBDAYLDH-VQIMIIECSA-N	50271172	CHEMBL4127711	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271172&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202062	405255749							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804467	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H19FN6O3S/c1-27-19(23)26-20(8-2-3-17(20)31(27,29)30)14-9-13(5-6-15(14)21)25-18(28)16-7-4-12(10-22)11-24-16/h4-7,9,11,17H,2-3,8H2,1H3,(H2,23,26)(H,25,28)/t17-,20-/m1/s1	YIYHJEBMLKIUPV-YLJYHZDGSA-N	50271173	CHEMBL4129113	Beta-secretase 2		 3.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271173&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202069	405255750							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804469	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(C)cn2)ccc1F	InChI=1S/C19H21FN6O3S/c1-11-9-23-15(10-22-11)17(27)24-12-5-6-14(20)13(8-12)19-7-3-4-16(19)30(28,29)26(2)18(21)25-19/h5-6,8-10,16H,3-4,7H2,1-2H3,(H2,21,25)(H,24,27)/t16-,19-/m1/s1	TZNJQQFHTFHSBF-VQIMIIECSA-N	50271174	CHEMBL4126480	Beta-secretase 2		 16.0								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271174&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201653	405255751							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804471	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(C)cn2)ccc1F	InChI=1S/C20H22FN5O3S/c1-12-5-8-16(23-11-12)18(27)24-13-6-7-15(21)14(10-13)20-9-3-4-17(20)30(28,29)26(2)19(22)25-20/h5-8,10-11,17H,3-4,9H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20-/m1/s1	PEGNNDOQUVAZJH-YLJYHZDGSA-N	50271167	CHEMBL4127870	Beta-secretase 2		 3.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271167&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201655	405255744							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804473	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F	InChI=1S/C19H18ClF2N5O3S/c1-27-18(23)26-19(6-2-3-15(19)31(27,29)30)12-8-11(4-5-13(12)21)25-17(28)16-14(22)7-10(20)9-24-16/h4-5,7-9,15H,2-3,6H2,1H3,(H2,23,26)(H,25,28)/t15-,19-/m1/s1	GYVDXWKQHSKJCJ-DNVCBOLYSA-N	50271163	CHEMBL4129654	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271163&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201660	405255740							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804475	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(F)cc2F)ccc1F	InChI=1S/C19H18F3N5O3S/c1-27-18(23)26-19(6-2-3-15(19)31(27,29)30)12-8-11(4-5-13(12)21)25-17(28)16-14(22)7-10(20)9-24-16/h4-5,7-9,15H,2-3,6H2,1H3,(H2,23,26)(H,25,28)/t15-,19-/m1/s1	NWDPGGJFZUSNSI-DNVCBOLYSA-N	50271175	CHEMBL4126365	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271175&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202063	405255752							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804477	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(F)cc2C)ccc1F	InChI=1S/C20H21F2N5O3S/c1-11-8-12(21)10-24-17(11)18(28)25-13-5-6-15(22)14(9-13)20-7-3-4-16(20)31(29,30)27(2)19(23)26-20/h5-6,8-10,16H,3-4,7H2,1-2H3,(H2,23,26)(H,25,28)/t16-,20-/m1/s1	WJPNPTZJGPWLCP-OXQOHEQNSA-N	50271168	CHEMBL4127283	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271168&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202057	405255745							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804479	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]23CCC[C@H]2S(=O)(=O)N(C)C(=N)N3)c(C)c1	InChI=1S/C21H24FN5O4S/c1-12-9-14(31-3)11-24-18(12)19(28)25-13-6-7-16(22)15(10-13)21-8-4-5-17(21)32(29,30)27(2)20(23)26-21/h6-7,9-11,17H,4-5,8H2,1-3H3,(H2,23,26)(H,25,28)/t17-,21-/m1/s1	GISBTRXXRSHQRN-DYESRHJHSA-N	402420	US10329291, Example 11	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402420	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402420&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202111	405262410							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804481	COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]23CCC[C@H]2S(=O)(=O)N(C)C(=N)N3)c(C)n1	InChI=1S/C20H23FN6O4S/c1-11-17(23-10-16(24-11)31-3)18(28)25-12-6-7-14(21)13(9-12)20-8-4-5-15(20)32(29,30)27(2)19(22)26-20/h6-7,9-10,15H,4-5,8H2,1-3H3,(H2,22,26)(H,25,28)/t15-,20-/m1/s1	YDAUYASJAKMRQF-FOIQADDNSA-N	50271171	CHEMBL4125904	Beta-secretase 2		 6.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271171&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202106	405255748							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804483	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C21H21FN6O3S/c1-12-8-13(10-23)11-25-18(12)19(29)26-14-5-6-16(22)15(9-14)21-7-3-4-17(21)32(30,31)28(2)20(24)27-21/h5-6,8-9,11,17H,3-4,7H2,1-2H3,(H2,24,27)(H,26,29)/t17-,21-/m1/s1	VDXQVJAEEQGQLD-DYESRHJHSA-N	402422	US10329291, Example 13	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402422	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402422&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202104	405262412							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804485	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)(F)F)ccc1F	InChI=1S/C19H18F4N6O3S/c1-29-17(24)28-18(6-2-3-15(18)33(29,31)32)11-7-10(4-5-12(11)20)27-16(30)13-8-26-14(9-25-13)19(21,22)23/h4-5,7-9,15H,2-3,6H2,1H3,(H2,24,28)(H,27,30)/t15-,18-/m1/s1	DSRWMANKTMPXKG-CRAIPNDOSA-N	402423	US10329291, Example 14	Beta-secretase 2		 40.0								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402423	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402423&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202107	405262413							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804487	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]12CCC[C@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C20H22FN5O4S/c1-26-19(22)25-20(9-3-4-17(20)31(26,28)29)14-10-12(5-7-15(14)21)24-18(27)16-8-6-13(30-2)11-23-16/h5-8,10-11,17H,3-4,9H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20-/m1/s1	YDWKWRWGRZUAPK-YLJYHZDGSA-N	402424	US10329291, Example 15	Beta-secretase 2		 3.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402424&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202321	405262414							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804489	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C20H20F4N6O4S/c1-30-18(25)29-19(6-2-3-15(19)35(30,32)33)12-7-11(4-5-13(12)21)28-17(31)14-8-27-16(9-26-14)34-10-20(22,23)24/h4-5,7-9,15H,2-3,6,10H2,1H3,(H2,25,29)(H,28,31)/t15-,19-/m1/s1	YIDXBFWAHSQOLK-DNVCBOLYSA-N	402425	US10329291, Example 16	Beta-secretase 2		 25.0								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402425	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402425&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202347	405262415							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804491	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]12CCC[C@H]1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C19H21FN6O4S/c1-26-18(21)25-19(7-3-4-15(19)31(26,28)29)12-8-11(5-6-13(12)20)24-17(27)14-9-23-16(30-2)10-22-14/h5-6,8-10,15H,3-4,7H2,1-2H3,(H2,21,25)(H,24,27)/t15-,19-/m1/s1	RZWPKMTXBIDSAY-DNVCBOLYSA-N	402426	US10329291, Example 17	Beta-secretase 2		 8.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402426	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402426&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202324	405262416							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804493	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(OCC#C)cn2)ccc1F	InChI=1S/C22H22FN5O4S/c1-3-11-32-15-7-9-18(25-13-15)20(29)26-14-6-8-17(23)16(12-14)22-10-4-5-19(22)33(30,31)28(2)21(24)27-22/h1,6-9,12-13,19H,4-5,10-11H2,2H3,(H2,24,27)(H,26,29)/t19-,22-/m1/s1	KRTFPNBGWDVTOU-DENIHFKCSA-N	402427	US10329291, Example 18	Beta-secretase 2		 17.0								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402427&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202035	405262417							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804495	COc1cnc2c(Nc3ccc(F)c(c3)[C@]34CCC[C@H]3S(=O)(=O)N(C)C(=N)N4)nccc2c1	InChI=1S/C22H23FN6O3S/c1-29-21(24)28-22(8-3-4-18(22)33(29,30)31)16-11-14(5-6-17(16)23)27-20-19-13(7-9-25-20)10-15(32-2)12-26-19/h5-7,9-12,18H,3-4,8H2,1-2H3,(H2,24,28)(H,25,27)/t18-,22-/m1/s1	ANSVHMJEANLWCE-XMSQKQJNSA-N	402428	US10329291, Example 19	Beta-secretase 2		 10.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402428&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201642	405262418							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804497	COc1cnc2c(Nc3ccc(F)c(c3)[C@]34CCC[C@H]3S(=O)(=O)N(C)C(=N)N4)nccc2n1	InChI=1S/C21H22FN7O3S/c1-29-20(23)28-21(8-3-4-16(21)33(29,30)31)13-10-12(5-6-14(13)22)26-19-18-15(7-9-24-19)27-17(32-2)11-25-18/h5-7,9-11,16H,3-4,8H2,1-2H3,(H2,23,28)(H,24,26)/t16-,21-/m1/s1	XPAQUQVFMRPMDY-IIBYNOLFSA-N	402429	US10329291, Example 20	Beta-secretase 2		 9.00								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402429&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201643	405262419							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804499	COc1cnc2c(Nc3ccc(F)c(c3)[C@]34CCC[C@H]3S(=O)(=O)N(C)C(=N)N4)ccnc2c1	InChI=1S/C22H23FN6O3S/c1-29-21(24)28-22(8-3-4-19(22)33(29,30)31)15-10-13(5-6-16(15)23)27-17-7-9-25-18-11-14(32-2)12-26-20(17)18/h5-7,9-12,19H,3-4,8H2,1-2H3,(H2,24,28)(H,25,27)/t19-,22-/m1/s1	OOSNAVKSOJJPDB-DENIHFKCSA-N	402430	US10329291, Example 21	Beta-secretase 2		 198								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402430&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201644	405262420							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804501	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(Nc2nccc3cc(Br)cnc23)ccc1F	InChI=1S/C21H20BrFN6O2S/c1-29-20(24)28-21(7-2-3-17(21)32(29,30)31)15-10-14(4-5-16(15)23)27-19-18-12(6-8-25-19)9-13(22)11-26-18/h4-6,8-11,17H,2-3,7H2,1H3,(H2,24,28)(H,25,27)/t17-,21-/m1/s1	PCMNXOOCUMIYSA-DYESRHJHSA-N	402431	US10329291, Example 22	Beta-secretase 2		 0.500								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402431	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402431&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201652	405262421							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804503	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(Nc2ncnc3cc(Br)cnc23)ccc1F	InChI=1S/C20H19BrFN7O2S/c1-29-19(23)28-20(6-2-3-16(20)32(29,30)31)13-8-12(4-5-14(13)22)27-18-17-15(25-10-26-18)7-11(21)9-24-17/h4-5,7-10,16H,2-3,6H2,1H3,(H2,23,28)(H,25,26,27)/t16-,20-/m1/s1	LYFUOUCTBFBWCS-OXQOHEQNSA-N	402432	US10329291, Example 23	Beta-secretase 2		 1.000								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402432	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402432&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129201965	405262422							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804505	CN1C(=N)NC2(CC2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H15ClFN5O3S/c1-24-16(20)23-17(7-14(17)28(24,26)27)11-6-10(3-4-12(11)19)22-15(25)13-5-2-9(18)8-21-13/h2-6,8,14H,7H2,1H3,(H2,20,23)(H,22,25)	ZHGYBRPOZJHRKE-UHFFFAOYSA-N	402433	US10329291, Example 32	Beta-secretase 2		 1157								US Patent		10.7270/Q2ZW1P72		aid1799348	US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402433&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202075	405262423							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804507	COCC(=O)Nc1ccc(F)c(c1)C12CCCC1S(=O)(=O)N(C)C(=N)N2	InChI=1S/C16H21FN4O4S/c1-21-15(18)20-16(7-3-4-13(16)26(21,23)24)11-8-10(5-6-12(11)17)19-14(22)9-25-2/h5-6,8,13H,3-4,7,9H2,1-2H3,(H2,18,20)(H,19,22)	GENCTSDDOMQPCQ-UHFFFAOYSA-N	402434	US10329291, Example 35	Beta-secretase 2		 16.0								US Patent		10.7270/Q2ZW1P72			US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402434	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402434&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202137	405262424							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804509	CN1C(=N)NC2(CCCC2S1(=O)=O)c1cc(NC(=O)C(F)F)ccc1F	InChI=1S/C15H17F3N4O3S/c1-22-14(19)21-15(6-2-3-11(15)26(22,24)25)9-7-8(4-5-10(9)16)20-13(23)12(17)18/h4-5,7,11-12H,2-3,6H2,1H3,(H2,19,21)(H,20,23)	GJNKCGGHTCPMIL-UHFFFAOYSA-N	402435	US10329291, Example 36	Beta-secretase 2		 71.0								US Patent		10.7270/Q2ZW1P72			US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402435	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402435&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202132	405262425							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
804510	CN1C(=N)NC2(CCCC2S1(=O)=O)c1ccccc1F	InChI=1S/C13H16FN3O2S/c1-17-12(15)16-13(9-5-2-3-6-10(9)14)8-4-7-11(13)20(17,18)19/h2-3,5-6,11H,4,7-8H2,1H3,(H2,15,16)	DGIMQAQBNIDCEW-UHFFFAOYSA-N	402436	US10329291, Example 37	Beta-secretase 2		 4087								US Patent		10.7270/Q2ZW1P72			US10329291	Scott, JD; Blizzard, TA; Walsh, SP; Cumming, JN	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402436	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402436&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202073	405262426							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51119382	C[C@]1(C=C(CF)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H15F2N5O2/c1-19(7-13(8-20)28-18(23)26-19)14-6-12(3-4-15(14)21)25-17(27)16-5-2-11(9-22)10-24-16/h2-7,10H,8H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1	ORHZQSYKGHHDOP-IBGZPJMESA-N	50457586	CHEMBL4213486	Beta-secretase 2			 86							ChEMBL	10.1021/acs.jmedchem.8b00002	10.7270/Q27W6FSQ	29733614			Fuchino, K; Mitsuoka, Y; Masui, M; Kurose, N; Yoshida, S; Komano, K; Yamamoto, T; Ogawa, M; Unemura, C; Hosono, M; Ito, H; Sakaguchi, G; Ando, S; Ohnishi, S; Kido, Y; Fukushima, T; Miyajima, H; Hiroyama, S; Koyabu, K; Dhuyvetter, D; Borghys, H; Gijsen, HJM; Yamano, Y; Iso, Y; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457586&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	0B6	5YGY	71466345	433924851							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109497	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(F)cn2)cs1	InChI=1S/C17H18FN5O2S2/c1-9-4-10-6-27-16(19)23-17(10,8-25-9)15-22-13(7-26-15)21-14(24)12-3-2-11(18)5-20-12/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,19,23)(H,21,24)/t9-,10-,17-/m0/s1	QQBRRRLRJBDPNK-YMNVWFMLSA-N	223322	US9315520, 9::US9605007, Example 9::US9744173, Example 9	Beta-secretase 2			 233							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223322&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435412	336285197							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109498	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(Cl)cn2)cs1	InChI=1S/C17H18ClN5O2S2/c1-9-4-10-6-27-16(19)23-17(10,8-25-9)15-22-13(7-26-15)21-14(24)12-3-2-11(18)5-20-12/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,19,23)(H,21,24)/t9-,10-,17-/m0/s1	UFKMIVRYLMOXNT-YMNVWFMLSA-N	223396	US9315520, 7::US9315520, Example 7::US9605007, Example 7	Beta-secretase 2			 20							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223396	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223396&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435407	336285271							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109499	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	YHYKUSGACIYRML-KRWDZBQOSA-N	47353	BDBM143220::US9029362, 173::US9687494, 25	Beta-secretase 2			 0.380000							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47353&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			1484169	24824350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109506	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(cn2)C#N)cs1	InChI=1S/C18H18N6O2S2/c1-10-4-12-7-28-17(20)24-18(12,9-26-10)16-23-14(8-27-16)22-15(25)13-3-2-11(5-19)6-21-13/h2-3,6,8,10,12H,4,7,9H2,1H3,(H2,20,24)(H,22,25)/t10-,12-,18-/m0/s1	TYNXFCODUDWTAD-RSNWOKGLSA-N	312940	N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-cyanopyridine-2-carboxamide::US9605007, Example 5	Beta-secretase 2			 61							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312940&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435403	383539889							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109570	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(cn2)C(F)(F)F)cs1	InChI=1S/C18H18F3N5O2S2/c1-9-4-11-6-30-16(22)26-17(11,8-28-9)15-25-13(7-29-15)24-14(27)12-3-2-10(5-23-12)18(19,20)21/h2-3,5,7,9,11H,4,6,8H2,1H3,(H2,22,26)(H,24,27)/t9-,11-,17-/m0/s1	ZZHRZUNUORUAKI-NSTVUXKKSA-N	223330	US9315520, 17::US9605007, Example 17::US9744173, Example 17	Beta-secretase 2			 338							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223330	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223330&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435560	336285205							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109571	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(Cl)cn2)cs1	InChI=1S/C17H18ClN5O2S2/c1-9-4-10-6-27-16(19)23-17(10,8-25-9)15-22-13(7-26-15)21-14(24)12-3-2-11(18)5-20-12/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,19,23)(H,21,24)/t9-,10-,17-/m0/s1	UFKMIVRYLMOXNT-YMNVWFMLSA-N	223396	US9315520, 7::US9315520, Example 7::US9605007, Example 7	Beta-secretase 2			 22							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223396	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223396&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435407	336285271							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109572	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1	InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10,8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3,5,7,9-10,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,10-,18-/m0/s1	ZLZUHACSRMOLLV-RAALSFIWSA-N	223395	US9315520, 1::US9315520, Comparator 1::US9315520, Example 1::US9315520, Example 2::US9605007, Example 1	Beta-secretase 2			 238							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223395&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435360	336285270							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109573	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(OC(F)F)cc2C)cs1	InChI=1S/C19H21F2N5O3S2/c1-9-3-12(29-17(20)21)5-23-14(9)15(27)24-13-7-30-16(25-13)19-8-28-10(2)4-11(19)6-31-18(22)26-19/h3,5,7,10-11,17H,4,6,8H2,1-2H3,(H2,22,26)(H,24,27)/t10-,11-,19-/m0/s1	CHAGAOAUIITKPC-ADWYPQAOSA-N	223400	US9315520, 45::US9315520, Example 45::US9605007, Example 45::US9744173, Example 45	Beta-secretase 2			 71							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223400	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223400&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435524	336285273							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109574	COc1cnc(cn1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C17H20N6O3S2/c1-9-3-10-6-28-16(18)23-17(10,8-26-9)15-22-12(7-27-15)21-14(24)11-4-20-13(25-2)5-19-11/h4-5,7,9-10H,3,6,8H2,1-2H3,(H2,18,23)(H,21,24)/t9-,10-,17-/m0/s1	OWMWOBMERLAIGE-YMNVWFMLSA-N	223323	US9315520, 10::US9605007, Example 10::US9744173, Example 10	Beta-secretase 2			 1709							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223323	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223323&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435506	336285198							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109575	NC1=N[C@]2(CCC[C@H]2CS1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H18F2N4OS/c20-12-3-6-16(23-9-12)17(26)24-13-4-5-15(21)14(8-13)19-7-1-2-11(19)10-27-18(22)25-19/h3-6,8-9,11H,1-2,7,10H2,(H2,22,25)(H,24,26)/t11-,19-/m0/s1	UIAVKAKVAXWNHJ-WLRWDXFRSA-N	50452877	CHEMBL4205912	Beta-secretase 2			 43							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44198935	433921691							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109578	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H17ClFN5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	VBWPFVMZZPWFMD-KRWDZBQOSA-N	143218	US8940748, 34::US9029362, 34::US9687494, 34	Beta-secretase 2			 3.3							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51039270	251971813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109579	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(OC(F)F)cc2C)cs1	InChI=1S/C19H21F2N5O3S2/c1-9-3-12(29-17(20)21)5-23-14(9)15(27)24-13-7-30-16(25-13)19-8-28-10(2)4-11(19)6-31-18(22)26-19/h3,5,7,10-11,17H,4,6,8H2,1-2H3,(H2,22,26)(H,24,27)/t10-,11-,19-/m0/s1	CHAGAOAUIITKPC-ADWYPQAOSA-N	223400	US9315520, 45::US9315520, Example 45::US9605007, Example 45::US9744173, Example 45	Beta-secretase 2			 57							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223400	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223400&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435524	336285273							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109580	NC1=N[C@]2(CCC[C@H]2CS1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H18F2N4OS/c20-12-3-6-16(23-9-12)17(26)24-13-4-5-15(21)14(8-13)19-7-1-2-11(19)10-27-18(22)25-19/h3-6,8-9,11H,1-2,7,10H2,(H2,22,25)(H,24,26)/t11-,19-/m0/s1	UIAVKAKVAXWNHJ-WLRWDXFRSA-N	50452877	CHEMBL4205912	Beta-secretase 2			 18							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44198935	433921691							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109584	C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1	InChI=1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1	MJQMRGWYPNIERM-HNNXBMFYSA-N	50012632	CHEMBL2333941	Beta-secretase 2			 2880							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012632&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	4B2	4YBI	44251605	103924885		CHEMBL2333941				ZINC18098141	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109585	CO[C@H]1CC[C@]2(Cc3ccc(cc3[C@@]22N=C(C)C(N)=N2)-c2cncc(c2)C#CC)CC1	InChI=1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,(H2,27,30)/t22-,25+,26-/m0/s1	WKDNQONLGXOZRG-DFCKQENNSA-N	50452874	CHEMBL4217620	Beta-secretase 2			 0.900000							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452874&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			67979346	433921688							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109586	Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C21H19F4N5O2/c1-11-6-12(8-26)9-28-16(11)17(31)29-13-4-5-15(22)14(7-13)19(2)10-32-20(3,18(27)30-19)21(23,24)25/h4-7,9H,10H2,1-3H3,(H2,27,30)(H,29,31)/t19-,20+/m0/s1	BQFHTVUWPJXLOW-VQTJNVASSA-N	50012653	CHEMBL3261067	Beta-secretase 2			 6.0							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012653	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012653&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	SLK	7B1Q	66665322	103924906		CHEMBL3261067				ZINC29463978	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109616	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(F)cc2C)cs1	InChI=1S/C18H20FN5O2S2/c1-9-3-12(19)5-21-14(9)15(25)22-13-7-27-16(23-13)18-8-26-10(2)4-11(18)6-28-17(20)24-18/h3,5,7,10-11H,4,6,8H2,1-2H3,(H2,20,24)(H,22,25)/t10-,11-,18-/m0/s1	MKJNGYHYSXIWAW-FHGNATFXSA-N	223326	US9315520, 13::US9605007, Example 13::US9744173, Example 13	Beta-secretase 2			 39							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223326&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435617	336285201							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109617	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)(F)F)cn2)cs1	InChI=1S/C18H18F3N5O3S2/c1-9-4-10-6-31-16(22)26-17(10,8-28-9)15-25-13(7-30-15)24-14(27)12-3-2-11(5-23-12)29-18(19,20)21/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,22,26)(H,24,27)/t9-,10-,17-/m0/s1	JGHWELLXLGSIDW-YMNVWFMLSA-N	223333	US9315520, 20::US9605007, Example 20::US9744173, Example 20	Beta-secretase 2			 1072							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223333&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435414	336285208							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109618	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccn(n2)C(F)F)cs1	InChI=1S/C16H18F2N6O2S2/c1-8-4-9-5-28-15(19)22-16(9,7-26-8)13-21-11(6-27-13)20-12(25)10-2-3-24(23-10)14(17)18/h2-3,6,8-9,14H,4-5,7H2,1H3,(H2,19,22)(H,20,25)/t8-,9-,16-/m0/s1	RODMHPIORBBNPR-BEPCFFQHSA-N	312938	N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-1-(difluoromethyl)-1H-pyrazole-3-carboxamide::US9605007, Example 4	Beta-secretase 2			 3.9							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312938&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435363	383539887							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109620	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1	InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10,8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3,5,7,9-10,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,10-,18-/m0/s1	ZLZUHACSRMOLLV-RAALSFIWSA-N	223395	US9315520, 1::US9315520, Comparator 1::US9315520, Example 1::US9315520, Example 2::US9605007, Example 1	Beta-secretase 2			 194							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223395&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435360	336285270							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109621	NC1=N[C@]2(CCC[C@H]2CS1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C19H18F2N4OS/c20-12-3-6-16(23-9-12)17(26)24-13-4-5-15(21)14(8-13)19-7-1-2-11(19)10-27-18(22)25-19/h3-6,8-9,11H,1-2,7,10H2,(H2,22,25)(H,24,26)/t11-,19-/m0/s1	UIAVKAKVAXWNHJ-WLRWDXFRSA-N	50452877	CHEMBL4205912	Beta-secretase 2			 10							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452877&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			44198935	433921691							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109633	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H17ClFN5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1	VBWPFVMZZPWFMD-KRWDZBQOSA-N	143218	US8940748, 34::US9029362, 34::US9687494, 34	Beta-secretase 2			 4.5							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=143218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=143218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			51039270	251971813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51109634	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(OC(F)F)cn2)cs1	InChI=1S/C17H18F2N6O3S2/c1-8-2-9-5-30-16(20)25-17(9,7-27-8)14-24-11(6-29-14)23-13(26)10-3-22-12(4-21-10)28-15(18)19/h3-4,6,8-9,15H,2,5,7H2,1H3,(H2,20,25)(H,23,26)/t8-,9-,17-/m0/s1	DVDAZKKMTJRHDZ-GSRNSYJJSA-N	312934	N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-(difluoromethoxy)pyrazine-2-carboxamide::US9605007, Example 2	Beta-secretase 2			 367							ChEMBL	10.1021/acs.jmedchem.8b00246	10.7270/Q23J3GJ5	29613789			O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA	Pfizer Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312934&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118435382	383539883							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51126359	CC(F)(F)[C@H]1OC(N)=N[C@@](C)([C@H]1F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C19H18F5N5O3/c1-18(14(22)15(19(2,23)24)32-17(25)29-18)10-5-9(3-4-11(10)21)28-16(30)12-6-27-13(7-26-12)31-8-20/h3-7,14-15H,8H2,1-2H3,(H2,25,29)(H,28,30)/t14-,15-,18+/m0/s1	DKIWJWSKVCKJPV-RLFYNMQTSA-N	50462002	CHEMBL4226994	Beta-secretase 2			 44							ChEMBL	10.1021/acs.jmedchem.8b00011	10.7270/Q2SB48DD	29775538			Nakahara, K; Fuchino, K; Komano, K; Asada, N; Tadano, G; Hasegawa, T; Yamamoto, T; Sako, Y; Ogawa, M; Unemura, C; Hosono, M; Ito, H; Sakaguchi, G; Ando, S; Ohnishi, S; Kido, Y; Fukushima, T; Dhuyvetter, D; Borghys, H; Gijsen, HJM; Yamano, Y; Iso, Y; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462002&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	0B5	5YGX	118440826	433929267							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51126370	C[C@@]1(N=C(N)O[C@@H]([C@@H]1F)C1(F)CC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C20H19F4N5O3/c1-19(15(23)16(20(24)4-5-20)32-18(25)29-19)11-6-10(2-3-12(11)22)28-17(30)13-7-27-14(8-26-13)31-9-21/h2-3,6-8,15-16H,4-5,9H2,1H3,(H2,25,29)(H,28,30)/t15-,16-,19+/m0/s1	IGZKUFGUJFXVMF-TXPKVOOTSA-N	50462008	CHEMBL4227851	Beta-secretase 2			 72							ChEMBL	10.1021/acs.jmedchem.8b00011	10.7270/Q2SB48DD	29775538			Nakahara, K; Fuchino, K; Komano, K; Asada, N; Tadano, G; Hasegawa, T; Yamamoto, T; Sako, Y; Ogawa, M; Unemura, C; Hosono, M; Ito, H; Sakaguchi, G; Ando, S; Ohnishi, S; Kido, Y; Fukushima, T; Dhuyvetter, D; Borghys, H; Gijsen, HJM; Yamano, Y; Iso, Y; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462008&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118441142	433929273							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51126371	C[C@@H](F)[C@H]1OC(N)=N[C@@](C)([C@H]1F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C19H19F4N5O3/c1-9(21)15-16(23)19(2,28-18(24)31-15)11-5-10(3-4-12(11)22)27-17(29)13-6-26-14(7-25-13)30-8-20/h3-7,9,15-16H,8H2,1-2H3,(H2,24,28)(H,27,29)/t9-,15-,16+,19-/m1/s1	XLLBJPJPZUZGIT-KRAREHRYSA-N	50462004	CHEMBL4226007	Beta-secretase 2			 30							ChEMBL	10.1021/acs.jmedchem.8b00011	10.7270/Q2SB48DD	29775538			Nakahara, K; Fuchino, K; Komano, K; Asada, N; Tadano, G; Hasegawa, T; Yamamoto, T; Sako, Y; Ogawa, M; Unemura, C; Hosono, M; Ito, H; Sakaguchi, G; Ando, S; Ohnishi, S; Kido, Y; Fukushima, T; Dhuyvetter, D; Borghys, H; Gijsen, HJM; Yamano, Y; Iso, Y; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462004&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126693206	433929269							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194220	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F	InChI=1S/C15H12ClF5N6O2/c1-14(15(20,21)5-29-13(22)25-14)10-7(17)2-3-8(23-10)24-11(28)9-6(16)4-27(26-9)12(18)19/h2-4,12H,5H2,1H3,(H2,22,25)(H,23,24,28)/t14-/m1/s1	PUANGZKWYIUWGX-CQSZACIVSA-N	186075	US9163011, 30	Beta-secretase 2			 7.0							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186075&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529426	315658610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194221	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(OCC(F)F)nc2N)ccc1F	InChI=1S/C17H16F5N7O3/c1-16(17(21,22)6-32-15(24)29-16)12-7(18)2-3-9(26-12)27-14(30)11-13(23)28-10(4-25-11)31-5-8(19)20/h2-4,8H,5-6H2,1H3,(H2,23,28)(H2,24,29)(H,26,27,30)/t16-/m1/s1	FKUWIXCLOXGDMB-MRXNPFEDSA-N	186057	US9163011, 11	Beta-secretase 2			 2900							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186057&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529265	315658592							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194222	COCC[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C20H19F3N6O3/c1-11-7-12(8-24)9-26-15(11)17(30)28-14-4-3-13(21)16(27-14)19(5-6-31-2)20(22,23)10-32-18(25)29-19/h3-4,7,9H,5-6,10H2,1-2H3,(H2,25,29)(H,27,28,30)/t19-/m1/s1	PSPGXNMAHYIESQ-LJQANCHMSA-N	186050	US9163011, 4	Beta-secretase 2			 580							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186050&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273947	315658585							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194223	CC1(C)OC(N)=N[C@](C)(c2nc(NC(=O)c3ncc(cc3Cl)C#N)ccc2F)C1(F)F	InChI=1S/C19H16ClF3N6O2/c1-17(2)19(22,23)18(3,29-16(25)31-17)14-11(21)4-5-12(27-14)28-15(30)13-10(20)6-9(7-24)8-26-13/h4-6,8H,1-3H3,(H2,25,29)(H,27,28,30)/t18-/m1/s1	VZKPBWICQCZMIB-GOSISDBHSA-N	186049	US9163011, 3	Beta-secretase 2			 71							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186049&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274016	315658584							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194224	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C17H12ClF3N6O2/c1-16(17(20,21)7-29-15(23)27-16)13-10(19)2-3-11(25-13)26-14(28)12-9(18)4-8(5-22)6-24-12/h2-4,6H,7H2,1H3,(H2,23,27)(H,25,26,28)/t16-/m1/s1	XZRLHXIFWZKMCO-MRXNPFEDSA-N	186048	US9163011, 2	Beta-secretase 2			 71							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186048&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274019	315658583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194229	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C16H12Cl2F3N5O2/c1-15(16(20,21)6-28-14(22)26-15)12-9(19)2-3-10(24-12)25-13(27)11-8(18)4-7(17)5-23-11/h2-5H,6H2,1H3,(H2,22,26)(H,24,25,27)/t15-/m1/s1	CGFNKFZCIRBOAD-OAHLLOKOSA-N	186055	US9163011, 9	Beta-secretase 2			 4.0							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186055&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71273898	315658590							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194234	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C17H12ClF6N5O2/c1-15(16(20,21)6-31-14(25)29-15)12-9(19)2-3-10(27-12)28-13(30)11-8(18)4-7(5-26-11)17(22,23)24/h2-5H,6H2,1H3,(H2,25,29)(H,27,28,30)/t15-/m1/s1	LOLRSSGXRIPFCB-OAHLLOKOSA-N	186053	US9163011, 7	Beta-secretase 2			 290							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186053&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529262	315658588							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51194237	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C17H13F3N6O2/c1-16(17(19,20)8-28-15(22)26-16)13-10(18)3-5-12(24-13)25-14(27)11-4-2-9(6-21)7-23-11/h2-5,7H,8H2,1H3,(H2,22,26)(H,24,25,27)/t16-/m1/s1	ZWUWGLTVWPXQQS-MRXNPFEDSA-N	186080	US9163011, 35	Beta-secretase 2			 66							ChEMBL	10.1021/ml400104f	10.7270/Q24M97F6	24900690			Rosse, G	Dart Neuroscience LLC	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186080	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186080&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71529465	315658615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894525	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C19H20F2N4O4S/c1-11-8-16-19(10-28-11,24-18(22)25(2)30(16,26)27)13-9-12(5-6-14(13)20)29-17-15(21)4-3-7-23-17/h3-7,9,11,16H,8,10H2,1-2H3,(H2,22,24)/t11-,16+,19+/m0/s1	AODZWHJDYVNTJZ-YARKZXGKSA-N	439198	US10604534, Example 1	Beta-secretase 2		 1.60								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439198&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462328	439660771							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894527	COc1ccnc(Oc2ccc(F)c(c2)[C@]23CO[C@@H](C)C[C@H]2S(=O)(=O)N(C)C(=N)N3)n1	InChI=1S/C19H22FN5O5S/c1-11-8-15-19(10-29-11,24-17(21)25(2)31(15,26)27)13-9-12(4-5-14(13)20)30-18-22-7-6-16(23-18)28-3/h4-7,9,11,15H,8,10H2,1-3H3,(H2,21,24)/t11-,15+,19+/m0/s1	XPLUJYICMPHZLT-SVBQJQNYSA-N	439199	US10604534, Example 2	Beta-secretase 2		 9.60								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439199&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137474676	439660772							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894529	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C20H20FN5O4S/c1-12-7-17-20(11-29-12,25-19(23)26(2)31(17,27)28)15-9-14(3-4-16(15)21)30-18-8-13(10-22)5-6-24-18/h3-6,8-9,12,17H,7,11H2,1-2H3,(H2,23,25)/t12-,17+,20+/m0/s1	VLTDDKJCFRXASZ-LCIZUOBNSA-N	439200	US10604534, Example 3	Beta-secretase 2		 2.30								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439200&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462329	439660773							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894531	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2ncncc2F)ccc1F	InChI=1S/C18H19F2N5O4S/c1-10-5-15-18(8-28-10,24-17(21)25(2)30(15,26)27)12-6-11(3-4-13(12)19)29-16-14(20)7-22-9-23-16/h3-4,6-7,9-10,15H,5,8H2,1-2H3,(H2,21,24)/t10-,15+,18+/m0/s1	XFUDMMDTCQTWKA-WQFPPAFTSA-N	439201	US10604534, Example 4	Beta-secretase 2		 5.90								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439201&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462315	439660774							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894533	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C19H19F3N4O4S/c1-10-5-16-19(9-29-10,25-18(23)26(2)31(16,27)28)13-7-12(3-4-14(13)21)30-17-15(22)6-11(20)8-24-17/h3-4,6-8,10,16H,5,9H2,1-2H3,(H2,23,25)/t10-,16+,19+/m0/s1	FDBZCNFCPZYJMR-INZKUCGCSA-N	439202	US10604534, Example 5	Beta-secretase 2		 13.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439202&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462324	439660775							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894535	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cc(F)cnc2F)ccc1F	InChI=1S/C19H19F3N4O4S/c1-10-5-16-19(9-29-10,25-18(23)26(2)31(16,27)28)13-7-12(3-4-14(13)21)30-15-6-11(20)8-24-17(15)22/h3-4,6-8,10,16H,5,9H2,1-2H3,(H2,23,25)/t10-,16+,19+/m0/s1	FIAQQUCFFLBBCW-INZKUCGCSA-N	439203	US10604534, Example 6	Beta-secretase 2		 15.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439203&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462322	439660776							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894537	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F	InChI=1S/C18H24FN3O4S/c1-11-7-16-18(10-26-11,21-17(20)22(2)27(16,23)24)14-8-13(5-6-15(14)19)25-9-12-3-4-12/h5-6,8,11-12,16H,3-4,7,9-10H2,1-2H3,(H2,20,21)/t11-,16+,18+/m0/s1	XRWJNSMTNNCTLX-LIXBPZJASA-N	439205	US10604534, Example 7	Beta-secretase 2		 4.30								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439205&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462323	439660778							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894539	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(OCC23CC(C2)(C3)C#N)ccc1F	InChI=1S/C21H25FN4O4S/c1-13-5-17-21(12-29-13,25-18(24)26(2)31(17,27)28)15-6-14(3-4-16(15)22)30-11-20-7-19(8-20,9-20)10-23/h3-4,6,13,17H,5,7-9,11-12H2,1-2H3,(H2,24,25)/t13-,17+,19?,20?,21+/m0/s1	YUUYEMHUKXOIQP-CACMTQRNSA-N	439242	US10604534, Example 8	Beta-secretase 2		 28.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439242&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462310	439660808							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894541	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cncc(OC)n2)ccc1F	InChI=1S/C20H24FN5O6S/c1-26-19(22)25-20(11-31-13(10-29-2)7-16(20)33(26,27)28)14-6-12(4-5-15(14)21)32-18-9-23-8-17(24-18)30-3/h4-6,8-9,13,16H,7,10-11H2,1-3H3,(H2,22,25)/t13-,16-,20-/m1/s1	XWNCHOQFVBWCNL-OWDMVUQNSA-N	439249	US10604534, Example 9	Beta-secretase 2		 9.40								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439249&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462319	439660813							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894543	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C21H22FN5O5S/c1-27-20(24)26-21(12-31-15(11-30-2)9-18(21)33(27,28)29)16-8-14(3-4-17(16)22)32-19-7-13(10-23)5-6-25-19/h3-8,15,18H,9,11-12H2,1-2H3,(H2,24,26)/t15-,18-,21-/m1/s1	IKXTYERQAYAFRG-FQELHTAISA-N	439250	US10604534, Example 10	Beta-secretase 2		 3.40								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462330	439660814							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894545	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2ncncc2F)ccc1F	InChI=1S/C19H21F2N5O5S/c1-26-18(22)25-19(9-30-12(8-29-2)6-16(19)32(26,27)28)13-5-11(3-4-14(13)20)31-17-15(21)7-23-10-24-17/h3-5,7,10,12,16H,6,8-9H2,1-2H3,(H2,22,25)/t12-,16-,19-/m1/s1	XBFTYZYAZCATII-SMNXXWJPSA-N	439294	US10604534, Example 11	Beta-secretase 2		 4.50								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439294&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			130302452	439660853							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894547	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C20H21F3N4O5S/c1-27-19(24)26-20(10-31-13(9-30-2)7-17(20)33(27,28)29)14-6-12(3-4-15(14)22)32-18-16(23)5-11(21)8-25-18/h3-6,8,13,17H,7,9-10H2,1-2H3,(H2,24,26)/t13-,17-,20-/m1/s1	JKCJILQQIJXQMN-YXKFXFPPSA-N	439295	US10604534, Example 12	Beta-secretase 2		 18.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439295&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			130302451	439660854							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894549	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cc(F)cnc2F)ccc1F	InChI=1S/C20H21F3N4O5S/c1-27-19(24)26-20(10-31-13(9-30-2)7-17(20)33(27,28)29)14-6-12(3-4-15(14)22)32-16-5-11(21)8-25-18(16)23/h3-6,8,13,17H,7,9-10H2,1-2H3,(H2,24,26)/t13-,17-,20-/m1/s1	OGEVSLFGHQATOX-YXKFXFPPSA-N	439296	US10604534, Example 13	Beta-secretase 2		 10.00								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439296	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439296&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			130302449	439660855							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894551	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F	InChI=1S/C19H26FN3O5S/c1-23-18(21)22-19(11-28-14(10-26-2)8-17(19)29(23,24)25)15-7-13(5-6-16(15)20)27-9-12-3-4-12/h5-7,12,14,17H,3-4,8-11H2,1-2H3,(H2,21,22)/t14-,17-,19-/m1/s1	IXDJWXKMAOIDHJ-LSBZLQRGSA-N	439297	US10604534, Example 14	Beta-secretase 2		 2.00								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439297	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439297&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462327	439660856							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894553	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(OCC23CC(C2)(C3)C#N)ccc1F	InChI=1S/C22H27FN4O5S/c1-27-19(25)26-22(13-32-15(7-30-2)6-18(22)33(27,28)29)16-5-14(3-4-17(16)23)31-12-21-8-20(9-21,10-21)11-24/h3-5,15,18H,6-10,12-13H2,1-2H3,(H2,25,26)/t15-,18-,20?,21?,22-/m1/s1	XZHMPTVEHPFOGM-HXLKAGCFSA-N	439298	US10604534, Example 15	Beta-secretase 2		 28.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439298&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462320	439660857							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894555	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cccnc2)ccc1F	InChI=1S/C20H23FN4O5S/c1-25-19(22)24-20(12-29-15(11-28-2)9-18(20)31(25,26)27)16-8-13(5-6-17(16)21)30-14-4-3-7-23-10-14/h3-8,10,15,18H,9,11-12H2,1-2H3,(H2,22,24)/t15-,18-,20-/m1/s1	YFHWXSNPSQPXEP-XFQXTVEOSA-N	439299	US10604534, Example 16	Beta-secretase 2		 52.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439299	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439299&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462309	439660858							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894557	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cccc(c2)C#N)ccc1F	InChI=1S/C22H23FN4O5S/c1-27-21(25)26-22(13-31-17(12-30-2)10-20(22)33(27,28)29)18-9-16(6-7-19(18)23)32-15-5-3-4-14(8-15)11-24/h3-9,17,20H,10,12-13H2,1-2H3,(H2,25,26)/t17-,20-,22-/m1/s1	VAIHLFMEYBLAOV-NQSCKRDGSA-N	439300	US10604534, Example 17	Beta-secretase 2		 6.90								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439300&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462313	439660859							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894559	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cccnc2F)ccc1F	InChI=1S/C20H22F2N4O5S/c1-26-19(23)25-20(11-30-13(10-29-2)9-17(20)32(26,27)28)14-8-12(5-6-15(14)21)31-16-4-3-7-24-18(16)22/h3-8,13,17H,9-11H2,1-2H3,(H2,23,25)/t13-,17-,20-/m1/s1	FHBSPTRNXIDIQS-YXKFXFPPSA-N	439301	US10604534, Example 18	Beta-secretase 2		 36.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439301	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439301&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137474684	439660860							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
894561	COC[C@H]1C[C@@H]2[C@](CO1)(NC(=N)N(C)S2(=O)=O)c1cc(Oc2cnccc2Cl)ccc1F	InChI=1S/C20H22ClFN4O5S/c1-26-19(23)25-20(11-30-13(10-29-2)8-18(20)32(26,27)28)14-7-12(3-4-16(14)22)31-17-9-24-6-5-15(17)21/h3-7,9,13,18H,8,10-11H2,1-2H3,(H2,23,25)/t13-,18-,20-/m1/s1	KUMAPADHTBFEKZ-CFSSXQINSA-N	439302	US10604534, Example 19	Beta-secretase 2		 89.0								US Patent		10.7270/Q2057JXQ		aid1804361	US10604534	Walsh, SP; Cumming, JN; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=439302	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=439302&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			130302450	439660861							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249201	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2ncc(OCC#C)cc2C)cc(F)c1F	InChI=1S/C24H24F2N4O3S/c1-5-6-33-15-7-13(2)20(28-11-15)21(31)29-14-8-16(19(26)17(25)9-14)23(3)18-10-24(18,12-32-4)34-22(27)30-23/h1,7-9,11,18H,6,10,12H2,2-4H3,(H2,27,30)(H,29,31)/t18-,23+,24+/m0/s1	YCXRAGJRMCYSLB-NTUVXCKYSA-N	50510972	CHEMBL4452318	Beta-secretase 2			 31							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510972&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866133	440719554							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249208	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(F)F)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C21H17F4N5O2S/c1-3-4-32-15-9-27-13(8-28-15)17(31)29-10-5-11(16(23)12(22)6-10)20(2)14-7-21(14,18(24)25)33-19(26)30-20/h1,5-6,8-9,14,18H,4,7H2,2H3,(H2,26,30)(H,29,31)/t14-,20+,21-/m0/s1	NURKHPHCXJUBHN-DLPLYFIVSA-N	50510977	CHEMBL4577527	Beta-secretase 2			 9.7							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510977&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866986	440719559							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249209	C[C@@]1(N=C(N)S[C@@]2(CF)C[C@@H]12)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C19H16ClF3N4OS/c1-18(14-6-19(14,8-21)29-17(24)27-18)11-4-10(5-12(22)15(11)23)26-16(28)13-3-2-9(20)7-25-13/h2-5,7,14H,6,8H2,1H3,(H2,24,27)(H,26,28)/t14-,18+,19+/m0/s1	UKZKWTZATFOTDT-GDIGMMSISA-N	50510978	CHEMBL4539909	Beta-secretase 2			<2.0							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510978&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866454	440719560							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249234	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2ccc(OCC(F)(F)F)cn2)cc(F)c1F	InChI=1S/C22H21F5N4O3S/c1-20(16-7-21(16,9-33-2)35-19(28)31-20)13-5-11(6-14(23)17(13)24)30-18(32)15-4-3-12(8-29-15)34-10-22(25,26)27/h3-6,8,16H,7,9-10H2,1-2H3,(H2,28,31)(H,30,32)/t16-,20+,21+/m0/s1	BTFGNNJIHJZEND-ZLGUVYLKSA-N	50510988	CHEMBL4461994	Beta-secretase 2			 401							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510988&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866737	440719570							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249235	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2ccc(OCC#C)cn2)cc(F)c1F	InChI=1S/C23H22F2N4O3S/c1-4-7-32-14-5-6-17(27-11-14)20(30)28-13-8-15(19(25)16(24)9-13)22(2)18-10-23(18,12-31-3)33-21(26)29-22/h1,5-6,8-9,11,18H,7,10,12H2,2-3H3,(H2,26,29)(H,28,30)/t18-,22+,23+/m0/s1	XMBDVYLJVOJVAJ-CDNPAEQRSA-N	50510984	CHEMBL4456778	Beta-secretase 2			 40							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510984&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118885049	440719566							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249236	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)cc(F)c1F	InChI=1S/C21H20F5N5O3S/c1-19(14-5-20(14,8-33-2)35-18(27)31-19)11-3-10(4-12(22)16(11)23)30-17(32)13-6-29-15(7-28-13)34-9-21(24,25)26/h3-4,6-7,14H,5,8-9H2,1-2H3,(H2,27,31)(H,30,32)/t14-,19+,20+/m0/s1	LMVCXQSYVBPNAZ-VHKYSDTDSA-N	50510985	CHEMBL4579155	Beta-secretase 2			 40							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510985&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866551	440719567							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249237	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2cnc(OCCC(F)(F)F)cn2)cc(F)c1F	InChI=1S/C22H22F5N5O3S/c1-20(15-7-21(15,10-34-2)36-19(28)32-20)12-5-11(6-13(23)17(12)24)31-18(33)14-8-30-16(9-29-14)35-4-3-22(25,26)27/h5-6,8-9,15H,3-4,7,10H2,1-2H3,(H2,28,32)(H,31,33)/t15-,20+,21+/m0/s1	PXXKPAMPVRIFRU-IWMITWMQSA-N	50510990	CHEMBL4544525	Beta-secretase 2			 562							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510990&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866162	440719572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249238	CCCOc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(C)N=C(N)S[C@@]2(COC)C[C@@H]12	InChI=1S/C22H25F2N5O3S/c1-4-5-32-17-10-26-15(9-27-17)19(30)28-12-6-13(18(24)14(23)7-12)21(2)16-8-22(16,11-31-3)33-20(25)29-21/h6-7,9-10,16H,4-5,8,11H2,1-3H3,(H2,25,29)(H,28,30)/t16-,21+,22+/m0/s1	KJGHYDVBLIXARQ-KNXBSLHKSA-N	50510975	CHEMBL4575413	Beta-secretase 2			 94							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510975&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155563658	440719557							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249239	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C23H22F2N6O3S/c1-5-6-34-17-11-27-15(10-28-17)19(32)29-12-7-13(18(25)14(24)8-12)22(2)16-9-23(16,20(33)31(3)4)35-21(26)30-22/h1,7-8,10-11,16H,6,9H2,2-4H3,(H2,26,30)(H,29,32)/t16-,22+,23-/m0/s1	PENUXFUKWLPNBH-FNVCAUGXSA-N	50510987	CHEMBL4472708	Beta-secretase 2			 0.800000							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510987&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118865901	440719569							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249240	C[C@@]1(N=C(N)S[C@H]2C[C@@H]12)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C18H15ClF2N4OS/c1-18(10-6-14(10)27-17(22)25-18)11-4-9(5-12(20)15(11)21)24-16(26)13-3-2-8(19)7-23-13/h2-5,7,10,14H,6H2,1H3,(H2,22,25)(H,24,26)/t10-,14+,18+/m1/s1	GPAXGFDBMSTBMT-RHXQLXPWSA-N	50510973	CHEMBL4460278	Beta-secretase 2			 1.8							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510973&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866094	440719555							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249244	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C19H15ClF4N4OS/c1-18(13-6-19(13,16(23)24)30-17(25)28-18)10-4-9(5-11(21)14(10)22)27-15(29)12-3-2-8(20)7-26-12/h2-5,7,13,16H,6H2,1H3,(H2,25,28)(H,27,29)/t13-,18+,19-/m0/s1	WDWGHBQCXQLANW-BKTGTZMESA-N	50510980	CHEMBL4457316	Beta-secretase 2			<2.0							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510980&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866838	440719562							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249245	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(N)=O)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C19H16ClF2N5O2S/c1-18(13-6-19(13,16(23)29)30-17(24)27-18)10-4-9(5-11(21)14(10)22)26-15(28)12-3-2-8(20)7-25-12/h2-5,7,13H,6H2,1H3,(H2,23,29)(H2,24,27)(H,26,28)/t13-,18+,19-/m0/s1	GFKZOZZWSTUQPW-BKTGTZMESA-N	50510981	CHEMBL4468455	Beta-secretase 2			<2.0							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510981&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866474	440719563							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249246	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C21H20ClF2N5O2S/c1-20(15-8-21(15,18(31)29(2)3)32-19(25)28-20)12-6-11(7-13(23)16(12)24)27-17(30)14-5-4-10(22)9-26-14/h4-7,9,15H,8H2,1-3H3,(H2,25,28)(H,27,30)/t15-,20+,21-/m0/s1	RCUZRYJQRFWFIH-RVHYNSKXSA-N	50510982	CHEMBL4473740	Beta-secretase 2			<2.0							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510982&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866347	440719564							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249247	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C#N)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C19H14ClF2N5OS/c1-18(14-6-19(14,8-23)29-17(24)27-18)11-4-10(5-12(21)15(11)22)26-16(28)13-3-2-9(20)7-25-13/h2-5,7,14H,6H2,1H3,(H2,24,27)(H,26,28)/t14-,18+,19+/m0/s1	CFDRQUYOOKQSFL-GDIGMMSISA-N	50510992	CHEMBL4471141	Beta-secretase 2			<2.0							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510992&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866963	440719574							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249251	NC1=N[C@@]2(CO1)c1cc(ccc1Oc1c(F)nc(cc21)C1=CCCOC1)-c1cccnc1F	InChI=1S/C24H18F2N4O3/c25-21-15(4-1-7-28-21)13-5-6-19-16(9-13)24(12-32-23(27)30-24)17-10-18(14-3-2-8-31-11-14)29-22(26)20(17)33-19/h1,3-7,9-10H,2,8,11-12H2,(H2,27,30)/t24-/m0/s1	JAZOCUNZCUBRJX-DEOSSOPVSA-N	50510991	CHEMBL4564735	Beta-secretase 2			 56							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510991&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	3UT	4WTU,5UX4	53465141	440719573							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249263	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C22H21F2N5O3S/c1-4-5-32-17-10-26-15(9-27-17)19(30)28-12-6-13(18(24)14(23)7-12)21(2)16-8-22(16,11-31-3)33-20(25)29-21/h1,6-7,9-10,16H,5,8,11H2,2-3H3,(H2,25,29)(H,28,30)/t16-,21+,22+/m0/s1	IPUJINDWAGRAHN-KNXBSLHKSA-N	50510976	CHEMBL4560579	Beta-secretase 2			 19							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510976&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	P6J	6PZ4	118866105	440719558							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249264	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2cnc(OCc3ncco3)cn2)cc(F)c1F	InChI=1S/C23H22F2N6O4S/c1-22(16-7-23(16,11-33-2)36-21(26)31-22)13-5-12(6-14(24)19(13)25)30-20(32)15-8-29-17(9-28-15)35-10-18-27-3-4-34-18/h3-6,8-9,16H,7,10-11H2,1-2H3,(H2,26,31)(H,30,32)/t16-,22+,23+/m0/s1	LPXQIVMHUYETDK-PBNUPURSSA-N	50510986	CHEMBL4459222	Beta-secretase 2			 34							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510986&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866177	440719568							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249265	C[C@@]1(N=C(N)S[C@@]2(CF)C[C@@H]12)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C21H18F3N5O2S/c1-3-4-31-16-9-26-14(8-27-16)18(30)28-11-5-12(17(24)13(23)6-11)20(2)15-7-21(15,10-22)32-19(25)29-20/h1,5-6,8-9,15H,4,7,10H2,2H3,(H2,25,29)(H,28,30)/t15-,20+,21+/m0/s1	LNCNDCQMCRPPAO-IWMITWMQSA-N	50510993	CHEMBL4437161	Beta-secretase 2			 12							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510993&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866257	440719575							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249267	C[C@@]1(N=C(N)S[C@H]2C[C@@H]12)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C18H15ClF2N4OS/c1-18(10-6-14(10)27-17(22)25-18)11-4-9(5-12(20)15(11)21)24-16(26)13-3-2-8(19)7-23-13/h2-5,7,10,14H,6H2,1H3,(H2,22,25)(H,24,26)/t10-,14+,18+/m1/s1	GPAXGFDBMSTBMT-RHXQLXPWSA-N	50510973	CHEMBL4460278	Beta-secretase 2			 1.8							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510973&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866094	440719555							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249268	CNC(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C20H18ClF2N5O2S/c1-19(14-7-20(14,17(30)25-2)31-18(24)28-19)11-5-10(6-12(22)15(11)23)27-16(29)13-4-3-9(21)8-26-13/h3-6,8,14H,7H2,1-2H3,(H2,24,28)(H,25,30)(H,27,29)/t14-,19+,20-/m0/s1	ZGDXVGJMLHLEPG-KPOBHBOGSA-N	50510983	CHEMBL4475533	Beta-secretase 2			<2.0							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510983&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155538074	440719565							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249269	C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(F)F)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C21H17F4N5O2S/c1-3-4-32-15-9-27-13(8-28-15)17(31)29-10-5-11(16(23)12(22)6-10)20(2)14-7-21(14,18(24)25)33-19(26)30-20/h1,5-6,8-9,14,18H,4,7H2,2H3,(H2,26,30)(H,29,31)/t14-,20+,21-/m0/s1	NURKHPHCXJUBHN-DLPLYFIVSA-N	50510977	CHEMBL4577527	Beta-secretase 2			 1290							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510977&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866986	440719559							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249273	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C20H19ClF2N4O2S/c1-19(15-7-20(15,9-29-2)30-18(24)27-19)12-5-11(6-13(22)16(12)23)26-17(28)14-4-3-10(21)8-25-14/h3-6,8,15H,7,9H2,1-2H3,(H2,24,27)(H,26,28)/t15-,19+,20+/m0/s1	HYUOULLGMKCVMR-CWFSZBLJSA-N	50510974	CHEMBL4456863	Beta-secretase 2			 1.1							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510974&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118884907	440719556							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249282	CCOc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(C)N=C(N)S[C@@]2(COC)C[C@@H]12	InChI=1S/C21H23F2N5O3S/c1-4-31-16-9-25-14(8-26-16)18(29)27-11-5-12(17(23)13(22)6-11)20(2)15-7-21(15,10-30-3)32-19(24)28-20/h5-6,8-9,15H,4,7,10H2,1-3H3,(H2,24,28)(H,27,29)/t15-,20+,21+/m0/s1	JMBJLUDMTZCGCO-IWMITWMQSA-N	50510989	CHEMBL4593414	Beta-secretase 2			 94							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510989&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866403	440719571							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249283	NC1=N[C@@]2(CO1)c1cc(ccc1Oc1c(F)nc(cc21)C1=CCCOC1)-c1cccnc1F	InChI=1S/C24H18F2N4O3/c25-21-15(4-1-7-28-21)13-5-6-19-16(9-13)24(12-32-23(27)30-24)17-10-18(14-3-2-8-31-11-14)29-22(26)20(17)33-19/h1,3-7,9-10H,2,8,11-12H2,(H2,27,30)/t24-/m0/s1	JAZOCUNZCUBRJX-DEOSSOPVSA-N	50510991	CHEMBL4564735	Beta-secretase 2			 0.800000							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510991&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	3UT	4WTU,5UX4	53465141	440719573							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249284	COC[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C22H21F2N5O3S/c1-4-5-32-17-10-26-15(9-27-17)19(30)28-12-6-13(18(24)14(23)7-12)21(2)16-8-22(16,11-31-3)33-20(25)29-21/h1,6-7,9-10,16H,5,8,11H2,2-3H3,(H2,25,29)(H,28,30)/t16-,21+,22+/m0/s1	IPUJINDWAGRAHN-KNXBSLHKSA-N	50510976	CHEMBL4560579	Beta-secretase 2			 569							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510976&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	P6J	6PZ4	118866105	440719558							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51249287	C[C@@]1(N=C(N)S[C@@]2(CO)C[C@@H]12)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C19H17ClF2N4O2S/c1-18(14-6-19(14,8-27)29-17(23)26-18)11-4-10(5-12(21)15(11)22)25-16(28)13-3-2-9(20)7-24-13/h2-5,7,14,27H,6,8H2,1H3,(H2,23,26)(H,25,28)/t14-,18+,19+/m0/s1	SYUXGKTZZPXWFX-GDIGMMSISA-N	50510979	CHEMBL4575752	Beta-secretase 2			<2.0							ChEMBL	10.1021/acs.jmedchem.9b01034	10.7270/Q2ZK5M0H	31589043			Pettus, LH; Bourbeau, MP; Bradley, J; Bartberger, MD; Chen, K; Hickman, D; Johnson, M; Liu, Q; Manning, JR; Nanez, A; Siegmund, AC; Wen, PH; Whittington, DA; Allen, JR; Wood, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510979&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866030	440719561							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911676	C[C@]1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)/t16-/m0/s1	WQUQHUCOJVZXJC-INIZCTEOSA-N	116227	US10035794, Example 1::US10683287, Example 1::US8637508, 1	Beta-secretase 2			 260							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116227&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356238	199996611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911677	CC1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)	WQUQHUCOJVZXJC-UHFFFAOYSA-N	116228	US10035794, Example 2::US10683287, Example 2::US8637508, 2	Beta-secretase 2			 360							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116228&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57523959	199996612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911678	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Cl)cn2)n1	InChI=1S/C16H15ClFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)/p+1	CDJHOYHFBRGWII-UHFFFAOYSA-O	116229	US10683287, Example 3::US8637508, 3	Beta-secretase 2			 1400							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808725	199996613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911679	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H15BrFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)/p+1	HBAGGGIQIJILPN-UHFFFAOYSA-O	116230	BDBM279660::US10683287, Example 4::US8637508, 4	Beta-secretase 2			 1700							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116230&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808726	199996614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911680	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C17H15FN6O2/c18-9-17(10-26-8-14(20)24-17)13-2-1-3-15(22-13)23-16(25)12-5-4-11(6-19)7-21-12/h1-5,7H,8-10H2,(H2,20,24)(H,22,23,25)/p+1	ZYXUSDIABPAMMQ-UHFFFAOYSA-O	445479	US10683287, Example 5	Beta-secretase 2			 1000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445479&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802688	440707691							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911681	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccccn2)n1	InChI=1S/C16H16FN5O2/c17-9-16(10-24-8-13(18)22-16)12-5-3-6-14(20-12)21-15(23)11-4-1-2-7-19-11/h1-7H,8-10H2,(H2,18,22)(H,20,21,23)/p+1	GNOVUNXZSPAJHX-UHFFFAOYSA-O	445480	US10683287, Example 6	Beta-secretase 2			 240							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445480&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802690	440707692							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911682	NC(=S)c1ccc(nc1)C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17FN6O2S/c18-8-17(9-26-7-13(19)24-17)12-2-1-3-14(22-12)23-16(25)11-5-4-10(6-21-11)15(20)27/h1-6H,7-9H2,(H2,19,24)(H2,20,27)(H,22,23,25)/p+1	RWYPCDYBONWERI-UHFFFAOYSA-O	116232	US10683287, Example 7::US8637508, 7	Beta-secretase 2			 8700							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116232&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808728	199996616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911683	Cc1cc(cnc1C(=O)Nc1cccc(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H19F3N6O2/c1-11-7-12(8-24)9-26-15(11)16(30)28-14-6-4-5-13(27-14)18(2)10-31-19(3,17(25)29-18)20(21,22)23/h4-7,9H,10H2,1-3H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	HONUCNWSWWNZSP-RBUKOAKNSA-N	116233	US10035794, Example 8::US10683287, Example 8::US8637508, 8	Beta-secretase 2			 20.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116233&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356349	199996617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911684	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18+/m0/s1	QSCBNUCKFXAIJL-ZWKOTPCHSA-N	116235	US10035794, Example 10::US10683287, Example 10::US8637508, 10	Beta-secretase 2			 9900							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951951	199996619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911685	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18+/m0/s1	QSCBNUCKFXAIJL-ZWKOTPCHSA-N	116235	US10035794, Example 10::US10683287, Example 10::US8637508, 10	Beta-secretase 2			 100.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951951	199996619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911686	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	MTNQDQUYJFDVLS-RBUKOAKNSA-N	116236	US10035794, Example 11::US10683287, Example 11::US8637508, 11	Beta-secretase 2			 12.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116236&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356221	199996620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911687	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19-/m1/s1	MTNQDQUYJFDVLS-RTBURBONSA-N	116237	US10035794, Example 12::US10683287, Example 12::US8637508, 12	Beta-secretase 2			 1300							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355933	199996621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911688	Cc1cc(Cl)cnc1C(=O)Nc1cc(ccn1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17ClFN5O2/c1-10-4-12(18)6-22-15(10)16(25)23-14-5-11(2-3-21-14)17(8-19)9-26-7-13(20)24-17/h2-6H,7-9H2,1H3,(H2,20,24)(H,21,23,25)/p+1	OLVSRIFVQCSRTD-UHFFFAOYSA-O	445487	US10683287, Example 13	Beta-secretase 2			 1500							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445487	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445487&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802692	440707699							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911689	[NH3+]C1=NC(CF)(COC1)c1ccnc(NC(=O)c2ccc(Cl)cn2)c1	InChI=1S/C16H15ClFN5O2/c17-11-1-2-12(21-6-11)15(24)22-14-5-10(3-4-20-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,20,22,24)/p+1	GPJQSUWRIBDPMP-UHFFFAOYSA-O	116238	BDBM279670::US10683287, Example 14::US8637508, 14	Beta-secretase 2			 4800							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116238&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			91808729	199996622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911690	NC(=S)c1ccc(nc1)C(=O)Nc1cc(ccn1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17FN6O2S/c18-8-17(9-26-7-13(19)24-17)11-3-4-21-14(5-11)23-16(25)12-2-1-10(6-22-12)15(20)27/h1-6H,7-9H2,(H2,19,24)(H2,20,27)(H,21,23,25)/p+1	OSRZYZJSNAELFK-UHFFFAOYSA-O	445489	US10683287, Example 15	Beta-secretase 2			>10000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445489	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445489&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802693	440707701							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911691	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19+/m0/s1	VAFUDQUXHDFJQT-RBUKOAKNSA-N	116240	US10035794, Example 16::US10683287, Example 16::US8637508, 16	Beta-secretase 2			 55.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116240&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356350	199996624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911692	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19-/m1/s1	VAFUDQUXHDFJQT-RTBURBONSA-N	116241	US10035794, Example 17::US10683287, Example 17::US8637508, 17	Beta-secretase 2			 4200							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356355	199996625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911693	NC1=NC(CF)(COC1)c1cc(NC(=O)c2ccc(Br)cn2)cnc1Cl	InChI=1S/C16H14BrClFN5O2/c17-9-1-2-12(21-4-9)15(25)23-10-3-11(14(18)22-5-10)16(7-19)8-26-6-13(20)24-16/h1-5H,6-8H2,(H2,20,24)(H,23,25)	IZGSDQIFBJRHBB-UHFFFAOYSA-N	116242	US10683287, Example 18::US8637508, 18	Beta-secretase 2			 130							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116242&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			57524139	199996626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911694	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2N)C#N)n1	InChI=1S/C19H18F3N7O2/c1-17(9-31-18(2,16(25)29-17)19(20,21)22)12-4-3-5-13(27-12)28-15(30)14-11(24)6-10(7-23)8-26-14/h3-6,8H,9,24H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	QLMSSDKIDFGJDT-ZWKOTPCHSA-N	116243	US10035794, Example 19::US10683287, Example 19::US8637508, 19	Beta-secretase 2			 82.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116243&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355685	199996627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911695	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2Cl)C#N)n1	InChI=1S/C19H16ClF3N6O2/c1-17(9-31-18(2,16(25)29-17)19(21,22)23)12-4-3-5-13(27-12)28-15(30)14-11(20)6-10(7-24)8-26-14/h3-6,8H,9H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	DPIDWDAWIQYLLV-ZWKOTPCHSA-N	116244	US10035794, Example 20::US10683287, Example 20::US8637508, 20	Beta-secretase 2			 41.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116244&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356253	199996628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911696	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(Cl)cn2)n1	InChI=1S/C18H17ClF3N5O2/c1-16(9-29-17(2,15(23)27-16)18(20,21)22)12-4-3-5-13(25-12)26-14(28)11-7-6-10(19)8-24-11/h3-8H,9H2,1-2H3,(H2,23,27)(H,25,26,28)/t16-,17+/m0/s1	CKRKVUFHQBIJHR-DLBZAZTESA-N	445495	US10683287, Example 21	Beta-secretase 2			 8.00							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445495	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445495&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802695	440707707							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911697	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(Br)cc2Cl)n1	InChI=1S/C18H16BrClF3N5O2/c1-16(8-30-17(2,15(24)28-16)18(21,22)23)11-4-3-5-12(26-11)27-14(29)13-10(20)6-9(19)7-25-13/h3-7H,8H2,1-2H3,(H2,24,28)(H,26,27,29)/t16-,17+/m0/s1	VANDNQQVYPKEOC-DLBZAZTESA-N	116245	US10035794, Example 22::US10683287, Example 22::US8637508, 22	Beta-secretase 2			 5.00							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116245&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356247	199996629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911698	CC(F)(F)COc1cnc(C(=O)Nc2cccc(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(N)n1	InChI=1S/C20H22F5N7O3/c1-17(8-35-19(3,16(27)32-17)20(23,24)25)10-5-4-6-11(29-10)30-15(33)13-14(26)31-12(7-28-13)34-9-18(2,21)22/h4-7H,8-9H2,1-3H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t17-,19+/m0/s1	LCFXPMWBUJPQOA-PKOBYXMFSA-N	445497	US10683287, Example 23	Beta-secretase 2			>10000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445497&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802696	440707709							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911699	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	LHTZVIDMVHFLLF-ZWKOTPCHSA-N	116247	US10035794, Example 24::US10683287, Example 35::US8637508, 24	Beta-secretase 2			 10.00							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355131	199996631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911700	COc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)c1	InChI=1S/C20H21F4N5O3/c1-10-7-11(31-4)8-26-14(10)16(30)28-13-6-5-12(21)15(27-13)18(2)9-32-19(3,17(25)29-18)20(22,23)24/h5-8H,9H2,1-4H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	PWIJFDYDPIMSCV-RBUKOAKNSA-N	116248	US10035794, Example 25::US10683287, Example 25::US8637508, 25	Beta-secretase 2			 15.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356220	199996632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911701	Cc1cc(OCC(C)(F)F)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C22H23F6N5O3/c1-11-7-12(35-10-20(3,24)25)8-30-15(11)17(34)32-14-6-5-13(23)16(31-14)19(2)9-36-21(4,18(29)33-19)22(26,27)28/h5-8H,9-10H2,1-4H3,(H2,29,33)(H,31,32,34)/t19-,21+/m0/s1	BXDMBVYWTFWIFD-PZJWPPBQSA-N	445500	US10683287, Example 26	Beta-secretase 2			 6400							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445500&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802697	440707712							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911702	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2N)C#N)ccc1F	InChI=1S/C19H17F4N7O2/c1-17(8-32-18(2,16(26)30-17)19(21,22)23)14-10(20)3-4-12(28-14)29-15(31)13-11(25)5-9(6-24)7-27-13/h3-5,7H,8,25H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	MWIIPGZITGHTPU-ZWKOTPCHSA-N	116250	US10035794, Example 27::US10683287, Example 27::US8637508, 27	Beta-secretase 2			 12.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116250&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951901	199996634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911703	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	LHTZVIDMVHFLLF-ZWKOTPCHSA-N	116247	US10035794, Example 24::US10683287, Example 35::US8637508, 24	Beta-secretase 2			 1900							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355131	199996631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911704	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C(F)F	InChI=1S/C20H19F6N5O2/c1-9-6-10(15(22)23)7-28-13(9)16(32)30-12-5-4-11(21)14(29-12)18(2)8-33-19(3,17(27)31-18)20(24,25)26/h4-7,15H,8H2,1-3H3,(H2,27,31)(H,29,30,32)/t18-,19+/m0/s1	FPTLECCDBNIEHG-RBUKOAKNSA-N	445503	US10683287, Example 29	Beta-secretase 2			 24.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445503&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802698	440707715							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911705	Cc1cc(OC(F)F)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H19F6N5O3/c1-9-6-10(34-17(22)23)7-28-13(9)15(32)30-12-5-4-11(21)14(29-12)18(2)8-33-19(3,16(27)31-18)20(24,25)26/h4-7,17H,8H2,1-3H3,(H2,27,31)(H,29,30,32)/t18-,19+/m0/s1	IEGJECJTLOSIQV-RBUKOAKNSA-N	116252	US10035794, Example 29::US10683287, Example 30::US8637508, 29	Beta-secretase 2			 24.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116252&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			88602949	199996636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911706	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C18H15Cl2F4N5O2/c1-16(7-31-17(2,15(25)29-16)18(22,23)24)13-10(21)3-4-11(27-13)28-14(30)12-9(20)5-8(19)6-26-12/h3-6H,7H2,1-2H3,(H2,25,29)(H,27,28,30)/t16-,17+/m0/s1	DRKAFGKWERJHKK-DLBZAZTESA-N	116254	US10035794, Example 31::US10683287, Example 31::US8637508, 31	Beta-secretase 2			 1.000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951906	199996638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911707	Cc1cc(OCF)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H20F5N5O3/c1-10-6-11(32-9-21)7-27-14(10)16(31)29-13-5-4-12(22)15(28-13)18(2)8-33-19(3,17(26)30-18)20(23,24)25/h4-7H,8-9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	VZKUTAXMEIXBFQ-RBUKOAKNSA-N	116255	US10035794, Example 32::US10683287, Example 32::US8637508, 32	Beta-secretase 2			 7.00							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116255&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356240	199996639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911708	Cc1cnc(cn1)C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C18H18F4N6O2/c1-9-6-25-11(7-24-9)14(29)27-12-5-4-10(19)13(26-12)16(2)8-30-17(3,15(23)28-16)18(20,21)22/h4-7H,8H2,1-3H3,(H2,23,28)(H,26,27,29)/t16-,17+/m0/s1	QEEWKGAHKUUMAX-DLBZAZTESA-N	116256	US10035794, Example 33::US10683287, Example 33::US8637508, 33	Beta-secretase 2			 330							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356222	199996640							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911709	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C19H15ClF7N5O2/c1-16(7-34-17(2,15(28)32-16)19(25,26)27)13-10(21)3-4-11(30-13)31-14(33)12-9(20)5-8(6-29-12)18(22,23)24/h3-6H,7H2,1-2H3,(H2,28,32)(H,30,31,33)/t16-,17+/m0/s1	PSBBWFNMHDUTRH-DLBZAZTESA-N	116257	US10035794, Example 34::US10683287, Example 34::US8637508, 34	Beta-secretase 2			 30.0							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	BUH	6EQM	88602735	199996641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911710	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	LHTZVIDMVHFLLF-ZWKOTPCHSA-N	116247	US10035794, Example 24::US10683287, Example 35::US8637508, 24	Beta-secretase 2			 120							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355131	199996631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911711	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)ccc1F	InChI=1S/C19H16ClF6N5O3/c1-17(7-33-18(2,15(27)31-17)19(24,25)26)13-10(21)3-4-11(29-13)30-14(32)12-9(20)5-8(6-28-12)34-16(22)23/h3-6,16H,7H2,1-2H3,(H2,27,31)(H,29,30,32)/t17-,18+/m0/s1	DOJQNRYLSRMQDA-ZWKOTPCHSA-N	116253	US10035794, Example 30::US10683287, Example 36::US8637508, 30	Beta-secretase 2			 280							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951915	199996637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911712	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)COC(CF)(CF)C(N)=N1)C#N	InChI=1S/C20H19F3N6O2/c1-11-3-12(5-24)6-27-16(11)17(30)28-15-4-13(14(23)7-26-15)19(2)10-31-20(8-21,9-22)18(25)29-19/h3-4,6-7H,8-10H2,1-2H3,(H2,25,29)(H,26,28,30)/t19-/m0/s1	ZDOMSYMJUOFARG-IBGZPJMESA-N	116260	US10035794, Example 37::US10683287, Example 37::US8637508, 37	Beta-secretase 2			 430							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116260&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70351283	199996644							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911713	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m0/s1	GIKOSRRRDYUWLE-SFHVURJKSA-N	116261	US10035794, Example 38::US10683287, Example 38::US8637508, 38	Beta-secretase 2			 160							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355171	199996645							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911714	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m1/s1	GIKOSRRRDYUWLE-GOSISDBHSA-N	116262	US10035794, Example 39::US10683287, Example 39::US8637508, 39	Beta-secretase 2			 6500							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356010	199996646							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911715	NC1=N[C@](COC1)(C(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C17H12ClF3N6O2/c18-9-3-8(4-22)5-24-13(9)15(28)26-12-2-1-10(19)14(25-12)17(16(20)21)7-29-6-11(23)27-17/h1-3,5,16H,6-7H2,(H2,23,27)(H,25,26,28)/t17-/m0/s1	LVXIXHYWPFXDKS-KRWDZBQOSA-N	116263	US10035794, Example 40::US10683287, Example 40::US8637508, 40	Beta-secretase 2			 170							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116263&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356242	199996647							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911716	Cc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)n1	InChI=1S/C19H20F4N6O2/c1-9-7-25-13(10(2)26-9)15(30)28-12-6-5-11(20)14(27-12)17(3)8-31-18(4,16(24)29-17)19(21,22)23/h5-7H,8H2,1-4H3,(H2,24,29)(H,27,28,30)/t17-,18+/m0/s1	NHQMQCNPITZLAA-ZWKOTPCHSA-N	116264	US10035794, Example 41::US10683287, Example 41::US8637508, 41	Beta-secretase 2			 130							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951896	199996648							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911717	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OCCCF)nc2N)ccc1F	InChI=1S/C20H22F5N7O3/c1-18(9-35-19(2,17(27)32-18)20(23,24)25)14-10(22)4-5-11(29-14)30-16(33)13-15(26)31-12(8-28-13)34-7-3-6-21/h4-5,8H,3,6-7,9H2,1-2H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t18-,19+/m0/s1	JKHHBPZBBWGXHT-RBUKOAKNSA-N	116265	US10035794, Example 42::US10683287, Example 42::US8637508, 42	Beta-secretase 2			 1000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116265&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70356059	199996649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911718	COCCn1ccc2nc(C(=O)Nc3ccc(F)c(n3)[C@]3(C)CO[C@](C)(C(N)=N3)C(F)(F)F)c(N)nc12	InChI=1S/C22H24F4N8O3/c1-20(10-37-21(2,19(28)33-20)22(24,25)26)15-11(23)4-5-13(30-15)31-18(35)14-16(27)32-17-12(29-14)6-7-34(17)8-9-36-3/h4-7H,8-10H2,1-3H3,(H2,27,32)(H2,28,33)(H,30,31,35)/t20-,21+/m0/s1	MMFYRHYCSIOPDG-LEWJYISDSA-N	116266	US10035794, Example 43::US10683287, Example 43::US8637508, 43	Beta-secretase 2			>10000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116266&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			70355173	199996650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911719	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(nc2N)C(F)(F)F)ccc1F	InChI=1S/C18H16F7N7O2/c1-15(6-34-16(2,14(27)32-15)18(23,24)25)11-7(19)3-4-9(30-11)31-13(33)10-12(26)29-8(5-28-10)17(20,21)22/h3-5H,6H2,1-2H3,(H2,26,29)(H2,27,32)(H,30,31,33)/t15-,16+/m0/s1	HUQALVJHHCENTE-JKSUJKDBSA-N	116267	US10035794, Example 44::US10683287, Example 44::US8637508, 44	Beta-secretase 2			 180							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116267&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			89951897	199996651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911720	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(CC(F)F)nc2N)ccc1F	InChI=1S/C19H19F6N7O2/c1-17(7-34-18(2,16(27)32-17)19(23,24)25)13-9(20)3-4-11(30-13)31-15(33)12-14(26)29-8(6-28-12)5-10(21)22/h3-4,6,10H,5,7H2,1-2H3,(H2,26,29)(H2,27,32)(H,30,31,33)/t17-,18+/m0/s1	LATXLMKRYWCSIN-ZWKOTPCHSA-N	445519	US10683287, Example 45	Beta-secretase 2			>10000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445519	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445519&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802701	440707731							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911721	Cc1cn(nc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C(F)F	InChI=1S/C18H18F6N6O2/c1-8-6-30(15(20)21)29-11(8)13(31)27-10-5-4-9(19)12(26-10)16(2)7-32-17(3,14(25)28-16)18(22,23)24/h4-6,15H,7H2,1-3H3,(H2,25,28)(H,26,27,31)/t16-,17+/m0/s1	JXCFFZNWKKOAKG-DLBZAZTESA-N	445520	US10683287, Example 46	Beta-secretase 2			 5.00							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445520	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445520&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126487056	440707732							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911722	Cc1cc2N(CC(F)F)CCc2nc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C23H24F6N6O2/c1-11-8-14-13(6-7-35(14)9-15(25)26)31-17(11)19(36)33-16-5-4-12(24)18(32-16)21(2)10-37-22(3,20(30)34-21)23(27,28)29/h4-5,8,15H,6-7,9-10H2,1-3H3,(H2,30,34)(H,32,33,36)/t21-,22+/m0/s1	MROKGOMJRATJBK-FCHUYYIVSA-N	445521	US10683287, Example 47	Beta-secretase 2			 5400							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445521	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445521&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802702	440707733							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
911723	COCCN1CCc2nc(C(=O)Nc3ccc(F)c(n3)[C@]3(C)CO[C@](C)(C(N)=N3)C(F)(F)F)c(Cl)cc12	InChI=1S/C23H25ClF4N6O3/c1-21(11-37-22(2,20(29)33-21)23(26,27)28)18-13(25)4-5-16(31-18)32-19(35)17-12(24)10-15-14(30-17)6-7-34(15)8-9-36-3/h4-5,10H,6-9,11H2,1-3H3,(H2,29,33)(H,31,32,35)/t21-,22+/m0/s1	NFUNUXSOZVGRBS-FCHUYYIVSA-N	445522	US10683287, Example 48	Beta-secretase 2			>10000							US Patent		10.7270/Q2DZ0CCG		aid1804458	US10683287	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=445522	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=445522&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155802703	440707734							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248465	CN1CC2(C1)C(=N)N[C@@](C)(CS2(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H21ClFN5O3S/c1-19(11-31(29,30)20(18(23)26-19)9-27(2)10-20)14-7-13(4-5-15(14)22)25-17(28)16-6-3-12(21)8-24-16/h3-8H,9-11H2,1-2H3,(H2,23,26)(H,25,28)/t19-/m0/s1	JOSATGAYPZWFMY-IBGZPJMESA-N	249091	US9453034, 5	Beta-secretase 2		 1.2								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=249091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=249091&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85471653	346543602							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248467	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(NC(=S)c2ccc(cn2)C#N)ccc1F	InChI=1S/C18H17FN6O2S2/c1-18(10-29(26,27)25(2)17(21)24-18)13-7-12(4-5-14(13)19)23-16(28)15-6-3-11(8-20)9-22-15/h3-7,9H,10H2,1-2H3,(H2,21,24)(H,23,28)/t18-/m0/s1	YQLHPGDCNGMNFB-SFHVURJKSA-N	50510764	CHEMBL4458706	Beta-secretase 2		 1.000000								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510764	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510764&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155526564	440719346							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248471	CN=[S@@]1(=O)C[C@](C)(N=C(N)N1C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H20ClFN6O2S/c1-18(10-29(28,22-2)26(3)17(21)25-18)13-8-12(5-6-14(13)20)24-16(27)15-7-4-11(19)9-23-15/h4-9H,10H2,1-3H3,(H2,21,25)(H,24,27)/t18-,29-/m0/s1	TYBVENNBOHKGFL-YRVHBCJASA-N	50510767	CHEMBL4534877	Beta-secretase 2		 1.000000								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510767&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			85470889	440719349							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248476	CC(F)(F)[C@H]1OC[C@@]2(N=C(N)SC[C@H]12)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C21H18F6N4O2S/c1-19(23,24)16-13-8-34-18(28)31-20(13,9-33-16)12-6-11(3-4-14(12)22)30-17(32)15-5-2-10(7-29-15)21(25,26)27/h2-7,13,16H,8-9H2,1H3,(H2,28,31)(H,30,32)/t13-,16+,20-/m1/s1	XRFGNLFEFGYHSU-JOTOCRJQSA-N	50510770	CHEMBL4591139	Beta-secretase 2			 602							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510770&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155568510	440719352							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248480	C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C17H12ClF3N6O2/c1-16(17(20,21)7-29-15(23)27-16)13-10(19)2-3-11(25-13)26-14(28)12-9(18)4-8(5-22)6-24-12/h2-4,6H,7H2,1H3,(H2,23,27)(H,25,26,28)/t16-/m1/s1	XZRLHXIFWZKMCO-MRXNPFEDSA-N	186048	US9163011, 2	Beta-secretase 2			 71							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186048&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			71274019	315658583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248482	COc1ncc(C(=O)NC2CC2)c2C[C@H]3CSC(N)=N[C@]3(Cc12)c1ccc(F)cc1F	InChI=1S/C22H22F2N4O2S/c1-30-20-15-8-22(17-5-2-12(23)7-18(17)24)11(10-31-21(25)28-22)6-14(15)16(9-26-20)19(29)27-13-3-4-13/h2,5,7,9,11,13H,3-4,6,8,10H2,1H3,(H2,25,28)(H,27,29)/t11-,22-/m0/s1	GFWAXJPIGBKXCZ-SAHAZLINSA-N	50510774	CHEMBL4459963	Beta-secretase 2			 170							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510774&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153303564	440719356							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248484	C[C@]1(C[C@H](SC(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C19H17F5N4O2S/c1-18(7-15(19(22,23)24)31-17(25)28-18)12-6-10(2-4-13(12)21)27-16(29)14-5-3-11(8-26-14)30-9-20/h2-6,8,15H,7,9H2,1H3,(H2,25,28)(H,27,29)/t15-,18-/m0/s1	SNMHOUWVJNSJDG-YJBOKZPZSA-N	50510775	CHEMBL4445405	Beta-secretase 2			 1.000000							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510775&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155517833	440719357							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248485	C[C@]1(C[C@H](SC(N)=N1)C(F)F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C18H17F4N5O2S/c1-18(5-13(15(21)22)30-17(23)27-18)10-4-9(2-3-11(10)20)26-16(28)12-6-25-14(7-24-12)29-8-19/h2-4,6-7,13,15H,5,8H2,1H3,(H2,23,27)(H,26,28)/t13-,18-/m0/s1	YCQCOERWQMZZQJ-UGSOOPFHSA-N	50510776	CHEMBL4438526	Beta-secretase 2			 0.190000							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510776&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155513311	440719358							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248493	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H22F2N4O3S/c1-5-8-31-19-12-26-18(11-27-19)17(24)10-14-6-7-16(23)15(9-14)22(4)13-32(29,30)21(2,3)20(25)28-22/h1,6-7,9-12H,8,13H2,2-4H3,(H2,25,28)/b17-10-/t22-/m0/s1	MAJFETMMCMCMPJ-VBBNHBBTSA-N	50510783	CHEMBL4470897::US11021493, Example 123	Beta-secretase 2			 51							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125856	440719365							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248494	NC1=N[C@@](CF)([C@@H]2C[C@@]2(S1)C(F)F)c1cc(NC(=O)c2cnc(Cl)cn2)ccc1F	InChI=1S/C18H14ClF4N5OS/c19-13-6-25-11(5-26-13)14(29)27-8-1-2-10(21)9(3-8)17(7-20)12-4-18(12,15(22)23)30-16(24)28-17/h1-3,5-6,12,15H,4,7H2,(H2,24,28)(H,27,29)/t12-,17+,18-/m0/s1	DHESWQSXKSVRPU-RZAIGCCYSA-N	50510781	CHEMBL4460912	Beta-secretase 2			 13							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510781&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155528391	440719363							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248500	CC(F)(F)[C@H]1OC[C@@]2(N=C(N)SC[C@H]12)c1cc(NC(=O)c2cnc(cn2)-n2cncn2)ccc1F	InChI=1S/C21H19F3N8O2S/c1-20(23,24)17-13-7-35-19(25)31-21(13,8-34-17)12-4-11(2-3-14(12)22)30-18(33)15-5-28-16(6-27-15)32-10-26-9-29-32/h2-6,9-10,13,17H,7-8H2,1H3,(H2,25,31)(H,30,33)/t13-,17+,21-/m1/s1	XANIWDNIBGABPW-GQNMWPQZSA-N	50510786	CHEMBL4473955	Beta-secretase 2			 479							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510786&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122484483	440719368							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248503	CC(F)(F)[C@H]1OC[C@@]2(N=C(N)SC[C@H]12)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H18F3N5O2S/c1-20(23,24)17-14-9-32-19(26)29-21(14,10-31-17)13-6-12(3-4-15(13)22)28-18(30)16-5-2-11(7-25)8-27-16/h2-6,8,14,17H,9-10H2,1H3,(H2,26,29)(H,28,30)/t14-,17+,21-/m1/s1	JJADJMODPHLYCB-DAESXHAQSA-N	50510787	CHEMBL4564324	Beta-secretase 2			 18							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510787&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122653795	440719369							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248528	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C19H15ClF7N5O2/c1-16(7-34-17(2,15(28)32-16)19(25,26)27)13-10(21)3-4-11(30-13)31-14(33)12-9(20)5-8(6-29-12)18(22,23)24/h3-6H,7H2,1-2H3,(H2,28,32)(H,30,31,33)/t16-,17+/m0/s1	PSBBWFNMHDUTRH-DLBZAZTESA-N	116257	US10035794, Example 34::US10683287, Example 34::US8637508, 34	Beta-secretase 2			 30							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	BUH	6EQM	88602735	199996641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248539	CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCN(CCC(F)(F)F)C2)S1(=O)=O	InChI=1S/C23H25F5N6O3S/c1-21(16-11-15(4-5-17(16)25)31-19(35)18-6-3-14(24)12-30-18)22(38(36,37)33(2)20(29)32-21)7-9-34(13-22)10-8-23(26,27)28/h3-6,11-12H,7-10,13H2,1-2H3,(H2,29,32)(H,31,35)/t21-,22?/m1/s1	SDRRMAFKXWCTGV-ZMFCMNQTSA-N	50510798	CHEMBL4476845	Beta-secretase 2		 14								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510798&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155538495	440719380							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248540	CN1C(N)=N[C@@]2(CCOc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)CS1(=O)=O	InChI=1S/C19H18N6O4S/c1-25-18(21)24-19(11-30(25,27)28)6-7-29-16-5-3-13(8-14(16)19)23-17(26)15-4-2-12(9-20)10-22-15/h2-5,8,10H,6-7,11H2,1H3,(H2,21,24)(H,23,26)/t19-/m0/s1	BPNSGHKALGEYEE-IBGZPJMESA-N	50510799	CHEMBL4520547	Beta-secretase 2		 51								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510799&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122535397	440719381							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248541	CC1(C)C(N)=N[C@@]2(CCOc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)CS1(=O)=O	InChI=1S/C21H21N5O4S/c1-20(2)19(23)26-21(12-31(20,28)29)7-8-30-17-6-4-14(9-15(17)21)25-18(27)16-5-3-13(10-22)11-24-16/h3-6,9,11H,7-8,12H2,1-2H3,(H2,23,26)(H,25,27)/t21-/m0/s1	MUTRQBZDIQVCIM-NRFANRHFSA-N	50510766	CHEMBL4449989	Beta-secretase 2		 9.0								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510766&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			117960375	440719348							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248542	CN1C(N)=N[C@@]2(C)[C@@H](CCOc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)S1(=O)=O	InChI=1S/C20H20N6O4S/c1-20-14-9-13(24-18(27)15-5-3-12(10-21)11-23-15)4-6-16(14)30-8-7-17(20)31(28,29)26(2)19(22)25-20/h3-6,9,11,17H,7-8H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20-/m1/s1	WHPBHJQRLDCBOO-YLJYHZDGSA-N	50510800	CHEMBL4455948	Beta-secretase 2		 14								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510800&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264059	440719382							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248543	CN1C(N)=N[C@@]2(C)[C@H](CCOc3ccc(NC(=O)c4ccc(cn4)C#N)cc23)S1(=O)=O	InChI=1S/C20H20N6O4S/c1-20-14-9-13(24-18(27)15-5-3-12(10-21)11-23-15)4-6-16(14)30-8-7-17(20)31(28,29)26(2)19(22)25-20/h3-6,9,11,17H,7-8H2,1-2H3,(H2,22,25)(H,24,27)/t17-,20+/m0/s1	WHPBHJQRLDCBOO-FXAWDEMLSA-N	50510801	CHEMBL4587889	Beta-secretase 2		 303								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510801&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121264098	440719383							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248544	CN1C[C@H](N=C(N)C(C)(C)S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H21FN6O3S/c1-20(2)19(23)26-17(11-27(3)31(20,29)30)14-8-13(5-6-15(14)21)25-18(28)16-7-4-12(9-22)10-24-16/h4-8,10,17H,11H2,1-3H3,(H2,23,26)(H,25,28)/t17-/m0/s1	HFDVQFLUUCLMRC-KRWDZBQOSA-N	50510805	CHEMBL4525546	Beta-secretase 2		 32								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510805&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155543145	440719387							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248545	CN=[S@@]1(=O)C[C@](C)(N=C(N)C1(C)C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H23ClFN5O2S/c1-19(2)18(23)27-20(3,11-30(19,29)24-4)14-9-13(6-7-15(14)22)26-17(28)16-8-5-12(21)10-25-16/h5-10H,11H2,1-4H3,(H2,23,27)(H,26,28)/t20-,30+/m0/s1	LYWNLJBYWJZKJE-WENCNXQZSA-N	50510802	CHEMBL4473638	Beta-secretase 2		 1.000000								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510802&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155536534	440719384							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248546	C[C@]1(Cc2ncncc2C(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C20H16F2N6O/c1-20(7-17-13(18(23)28-20)9-24-10-26-17)14-6-12(3-4-15(14)22)27-19(29)16-5-2-11(21)8-25-16/h2-6,8-10H,7H2,1H3,(H2,23,28)(H,27,29)/t20-/m0/s1	BRCYVPIMBJJFFF-FQEVSTJZSA-N	50510804	CHEMBL4439298	Beta-secretase 2		 3.0								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510804&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118958876	440719386							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248550	C[C@]1(CC[C@](CF)(N=C1N)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F)S(C)(=O)=O	InChI=1S/C21H23F3N4O4S/c1-20(33(2,30)31)7-8-21(11-22,28-19(20)25)15-9-13(3-5-16(15)24)27-18(29)17-6-4-14(10-26-17)32-12-23/h3-6,9-10H,7-8,11-12H2,1-2H3,(H2,25,28)(H,27,29)/t20-,21-/m1/s1	DIDCPXSDZDVMCX-NHCUHLMSSA-N	50510806	CHEMBL4565391	Beta-secretase 2			 17							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510806&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155544727	440719388							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248551	COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC[C@@](C)(C#N)C(N)=N1	InChI=1S/C21H22FN5O2/c1-20(12-23)8-9-21(2,27-19(20)24)15-10-13(4-6-16(15)22)26-18(28)17-7-5-14(29-3)11-25-17/h4-7,10-11H,8-9H2,1-3H3,(H2,24,27)(H,26,28)/t20-,21-/m0/s1	CVLSLISEKNKGRA-SFTDATJTSA-N	50510768	CHEMBL4556248	Beta-secretase 2			 66							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510768&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155556725	440719350							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248562	NC1=N[C@]2(CO[C@@H]([C@H]2CO1)C(F)(F)F)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C20H15F7N4O3/c21-13-3-2-10(30-16(32)14-4-1-9(6-29-14)19(22,23)24)5-11(13)18-8-34-15(20(25,26)27)12(18)7-33-17(28)31-18/h1-6,12,15H,7-8H2,(H2,28,31)(H,30,32)/t12-,15+,18-/m1/s1	IUMONGPGCXVDPB-HNJNHCNJSA-N	50510811	CHEMBL4515824	Beta-secretase 2			 602							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510811&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			50898731	440719393							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248564	COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(N)=N3)nccc2c1	InChI=1S/C20H21FN6O3S/c1-20(11-31(28,29)27(2)19(22)26-20)15-9-13(4-5-16(15)21)25-18-17-12(6-7-23-18)8-14(30-3)10-24-17/h4-10H,11H2,1-3H3,(H2,22,26)(H,23,25)/t20-/m0/s1	QBRFLMCPVOBSGI-FQEVSTJZSA-N	50510812	CHEMBL4451647	Beta-secretase 2		 3.5								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510812&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122435134	440719394							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248565	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H15FN8O/c1-19(10-28-16(9-24-27-28)17(22)26-19)13-6-12(3-4-14(13)20)25-18(29)15-5-2-11(7-21)8-23-15/h2-6,8-9H,10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1	XIOGEDRAOXMYRT-IBGZPJMESA-N	338837	US9751886, Compound 2	Beta-secretase 2			 5.3							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338837&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86294744	384990811							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248566	C[C@]1(Cn2cnc(C(F)F)c2C(N)=N1)c1cc(NC(=O)c2ccc(cc2)C#N)ccc1F	InChI=1S/C22H17F3N6O/c1-22(10-31-11-28-17(19(24)25)18(31)20(27)30-22)15-8-14(6-7-16(15)23)29-21(32)13-4-2-12(9-26)3-5-13/h2-8,11,19H,10H2,1H3,(H2,27,30)(H,29,32)/t22-/m0/s1	VNTYARFSJRGDMJ-QFIPXVFZSA-N	50510773	CHEMBL4525240	Beta-secretase 2			 16							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510773&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155538806	440719355							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248567	NC1=N[C@]2(COC[C@H]2n2cccc12)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H17FN6O2/c23-16-5-4-14(27-21(30)17-6-3-13(9-24)10-26-17)8-15(16)22-12-31-11-19(22)29-7-1-2-18(29)20(25)28-22/h1-8,10,19H,11-12H2,(H2,25,28)(H,27,30)/t19-,22-/m1/s1	CDGLGEQWLCPBHO-DENIHFKCSA-N	50510813	CHEMBL4461226	Beta-secretase 2			 120							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510813&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			132604796	440719395							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248569	COc1ncc(CC2CCOCC2)c2C[C@H]3CSC(N)=N[C@]3(Cc12)c1ccc(F)cc1F	InChI=1S/C24H27F2N3O2S/c1-30-22-19-11-24(20-3-2-17(25)10-21(20)26)16(13-32-23(27)29-24)9-18(19)15(12-28-22)8-14-4-6-31-7-5-14/h2-3,10,12,14,16H,4-9,11,13H2,1H3,(H2,27,29)/t16-,24-/m0/s1	HOIGPFAVELSPMQ-FYSMJZIKSA-N	50510815	CHEMBL4530208	Beta-secretase 2			 6.6							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510815&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			154031826	440719397							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248570	CC(F)(F)[C@@H]1C[C@](C)(N=C(N)S1)c1cc(NC(=O)c2ccc(OCF)cn2)ccc1F	InChI=1S/C20H20F4N4O2S/c1-19(8-16(20(2,23)24)31-18(25)28-19)13-7-11(3-5-14(13)22)27-17(29)15-6-4-12(9-26-15)30-10-21/h3-7,9,16H,8,10H2,1-2H3,(H2,25,28)(H,27,29)/t16-,19-/m0/s1	RDTPYVBRIVZCGY-LPHOPBHVSA-N	50510816	CHEMBL4475802	Beta-secretase 2			 0.500000							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510816&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155537873	440719398							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248572	NC1=N[C@@](CF)([C@@H]2C[C@@H]2S1)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C20H16F3N5O2S/c1-2-3-30-16-8-25-14(7-26-16)18(29)27-10-4-12(17(23)13(22)5-10)20(9-21)11-6-15(11)31-19(24)28-20/h1,4-5,7-8,11,15H,3,6,9H2,(H2,24,28)(H,27,29)/t11-,15+,20+/m1/s1	YFUDKRKSUBTLCT-SZELWCTASA-N	50510782	CHEMBL4454250	Beta-secretase 2			 39							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510782&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118866499	440719364							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248579	CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1ccc([nH]1)-c1nnco1			242945	US9422277, 8	Beta-secretase 2		 11								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242945&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			73775748	341095084							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248586	NC1=N[C@@](CF)([C@H]2[C@@H](S1)C2(F)F)c1cc(NC(=O)c2cnc(Cl)cn2)cc(F)c1F	InChI=1S/C17H11ClF5N5OS/c18-10-4-25-9(3-26-10)14(29)27-6-1-7(11(21)8(20)2-6)16(5-19)12-13(17(12,22)23)30-15(24)28-16/h1-4,12-13H,5H2,(H2,24,28)(H,27,29)/t12-,13-,16-/m1/s1	FXZLMEMNHDMNJS-XJKCOSOUSA-N	50510821	CHEMBL4449357	Beta-secretase 2			 3.0							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510821&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155520705	440719403							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248600	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2nc3ccc(nc3s2)C#N)ccc1F	InChI=1S/C21H16F4N6O2S/c1-19(9-33-20(2,18(27)31-19)21(23,24)25)12-7-10(3-5-13(12)22)28-15(32)17-30-14-6-4-11(8-26)29-16(14)34-17/h3-7H,9H2,1-2H3,(H2,27,31)(H,28,32)/t19-,20+/m0/s1	HOQHGBYCOAWGHX-VQTJNVASSA-N	50510784	CHEMBL4440268	Beta-secretase 2			 446							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510784&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			134284187	440719366							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248606	CC1(C)C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H20FN5O4S/c1-20(2)19(24)27-21(11-31-10-17(21)32(20,29)30)14-7-13(4-5-15(14)22)26-18(28)16-6-3-12(8-23)9-25-16/h3-7,9,17H,10-11H2,1-2H3,(H2,24,27)(H,26,28)/t17-,21-/m1/s1	ZRQWZDZYZAYTLY-DYESRHJHSA-N	236591	US9365589, 1r	Beta-secretase 2		 1.000000								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236591&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			75593331	340130178							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248607	CN1C(=N)N[C@]2(CCC[C@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C19H19ClFN5O3S/c1-26-18(22)25-19(8-2-3-16(19)30(26,28)29)13-9-12(5-6-14(13)21)24-17(27)15-7-4-11(20)10-23-15/h4-7,9-10,16H,2-3,8H2,1H3,(H2,22,25)(H,24,27)/t16-,19-/m1/s1	SFRFSUMBDAYLDH-VQIMIIECSA-N	50271172	CHEMBL4127711	Beta-secretase 2		 1.000000								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271172&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			129202062	405255749							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248615	COC[C@H]1C[C@@H]2[C@](CO1)(N=C(N)N(C)S2(=O)=O)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C21H22FN5O5S/c1-27-20(24)26-21(12-31-15(11-30-2)9-18(21)33(27,28)29)16-8-14(3-4-17(16)22)32-19-7-13(10-23)5-6-25-19/h3-8,15,18H,9,11-12H2,1-2H3,(H2,24,26)/t15-,18-,21-/m1/s1	IKXTYERQAYAFRG-FQELHTAISA-N	50510803	CHEMBL4567636	Beta-secretase 2		 3.4								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510803&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137462330	440719385							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248616	C[C@H]1OC[C@@]2(N=C(N)[C@@](C)(C[C@H]12)C#N)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C23H21FN6O2/c1-13-17-8-22(2,11-26)21(27)30-23(17,12-32-13)16-7-15(4-5-18(16)24)29-20(31)19-6-3-14(9-25)10-28-19/h3-7,10,13,17H,8,12H2,1-2H3,(H2,27,30)(H,29,31)/t13-,17-,22+,23-/m1/s1	XCBQHELRLNEZJO-GVWYEHHWSA-N	50510814	CHEMBL4561901	Beta-secretase 2			 15							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510814&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			142342111	440719396							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248622	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C20H19F2N5O3S/c1-4-7-30-18-11-24-17(10-25-18)16(22)9-13-5-6-15(21)14(8-13)20(2)12-31(28,29)27(3)19(23)26-20/h1,5-6,8-11H,7,12H2,2-3H3,(H2,23,26)/b16-9-/t20-/m0/s1	WIQPRGHWWVQNAA-CPYXBQISSA-N	50510765	CHEMBL4440849::US11021493, Example 112	Beta-secretase 2			 52							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510765&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126469	440719347							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248629	CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(cn3)C#N)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C20H19FN6O3S/c1-19(20(7-8-20)31(29,30)27(2)18(23)26-19)14-9-13(4-5-15(14)21)25-17(28)16-6-3-12(10-22)11-24-16/h3-6,9,11H,7-8H2,1-2H3,(H2,23,26)(H,25,28)/t19-/m1/s1	DEBDBRRAVDUWFZ-LJQANCHMSA-N	50510827	CHEMBL4474110	Beta-secretase 2		 17								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510827	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510827&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118190070	440719409							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248630	C[C@]1(Cc2nccnc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H16FN7O/c1-21(9-17-18(19(24)29-21)26-7-6-25-17)14-8-13(3-4-15(14)22)28-20(30)16-5-2-12(10-23)11-27-16/h2-8,11H,9H2,1H3,(H2,24,29)(H,28,30)/t21-/m0/s1	MOKMVNJIQFEFGZ-NRFANRHFSA-N	50510828	CHEMBL4536395	Beta-secretase 2		 207								ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510828	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510828&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			118974304	440719410							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51248632	Cn1cc2C(N)=N[C@@](C)(Cn2c1=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H18FN7O2/c1-21(11-29-17(18(24)27-21)10-28(2)20(29)31)14-7-13(4-5-15(14)22)26-19(30)16-6-3-12(8-23)9-25-16/h3-7,9-10H,11H2,1-2H3,(H2,24,27)(H,26,30)/t21-/m0/s1	BUDULEITQIRFAU-NRFANRHFSA-N	50510789	CHEMBL4473230	Beta-secretase 2			 20							ChEMBL	10.1016/j.bmcl.2018.12.049	10.7270/Q2S185SH	30709653			Hsiao, CC; Rombouts, F; Gijsen, HJM	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510789&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86291837	440719371							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223080	C[C@]1(Cn2cccc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H17FN6O/c1-21(12-28-8-2-3-18(28)19(24)27-21)15-9-14(5-6-16(15)22)26-20(29)17-7-4-13(10-23)11-25-17/h2-9,11H,12H2,1H3,(H2,24,27)(H,26,29)/t21-/m0/s1	FZFJUKOAGOAQFB-NRFANRHFSA-N	50012662	CHEMBL3261075	Beta-secretase 2			 25							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012662&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	7D 	6OD6	90656190	103924915		CHEMBL3261075				ZINC29412051	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223087	C[C@]1(Cn2ccnc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H16FN7O/c1-20(11-28-7-6-24-18(28)17(23)27-20)14-8-13(3-4-15(14)21)26-19(29)16-5-2-12(9-22)10-25-16/h2-8,10H,11H2,1H3,(H2,23,27)(H,26,29)/t20-/m0/s1	PURBTYQRCRLUGF-FQEVSTJZSA-N	50502601	CHEMBL4525199	Beta-secretase 2			 141							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502601&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			121298035	440711186							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223088	C[C@]1(Cn2nccc2C(N)=N1)c1cccc(NC(=O)c2ccc(cn2)C#N)c1	InChI=1S/C20H17N7O/c1-20(12-27-17(7-8-24-27)18(22)26-20)14-3-2-4-15(9-14)25-19(28)16-6-5-13(10-21)11-23-16/h2-9,11H,12H2,1H3,(H2,22,26)(H,25,28)/t20-/m0/s1	WNSFYBCKLLABCJ-FQEVSTJZSA-N	50502598	CHEMBL4521954	Beta-secretase 2			 26							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502598&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			60194610	440711183							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223089	C[C@]1(Cn2cnnc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H15FN8O/c1-19(9-28-10-24-27-17(28)16(22)26-19)13-6-12(3-4-14(13)20)25-18(29)15-5-2-11(7-21)8-23-15/h2-6,8,10H,9H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1	ZSMIUGRYJRMLRW-IBGZPJMESA-N	50502596	CHEMBL4473647	Beta-secretase 2			 56							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502596&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155536618	440711181							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223090	C[C@]1(Cn2nnnc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C18H14FN9O/c1-18(9-28-16(15(21)24-18)25-26-27-28)12-6-11(3-4-13(12)19)23-17(29)14-5-2-10(7-20)8-22-14/h2-6,8H,9H2,1H3,(H2,21,24)(H,23,29)/t18-/m0/s1	NXQAJOXTJCKILO-SFHVURJKSA-N	50502600	CHEMBL4446937	Beta-secretase 2			 27							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502600&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155518836	440711185							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223104	C[C@]1(Cn2cncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C20H16FN7O/c1-20(10-28-11-24-9-17(28)18(23)27-20)14-6-13(3-4-15(14)21)26-19(29)16-5-2-12(7-22)8-25-16/h2-6,8-9,11H,10H2,1H3,(H2,23,27)(H,26,29)/t20-/m0/s1	OBLWDHIBZWAGSY-FQEVSTJZSA-N	50502602	CHEMBL4557890	Beta-secretase 2			 19							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502602&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86293009	440711187							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223105	C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H15FN8O/c1-19(10-28-16(9-24-27-28)17(22)26-19)13-6-12(3-4-14(13)20)25-18(29)15-5-2-11(7-21)8-23-15/h2-6,8-9H,10H2,1H3,(H2,22,26)(H,25,29)/t19-/m0/s1	XIOGEDRAOXMYRT-IBGZPJMESA-N	338837	US9751886, Compound 2	Beta-secretase 2			 5.5							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=338837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=338837&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			86294744	384990811							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51223109	C[C@]1(Cn2ncnc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H15FN8O/c1-19(9-28-17(16(22)27-19)24-10-25-28)13-6-12(3-4-14(13)20)26-18(29)15-5-2-11(7-21)8-23-15/h2-6,8,10H,9H2,1H3,(H2,22,27)(H,26,29)/t19-/m0/s1	JFCUNFPTQJPQES-IBGZPJMESA-N	50502599	CHEMBL4438397	Beta-secretase 2			 37							ChEMBL	10.1021/acsmedchemlett.9b00181	10.7270/Q2542RT5	31413800			Oehlrich, D; Peschiulli, A; Tresadern, G; Van Gool, M; Vega, JA; De Lucas, AI; Alonso de Diego, SA; Prokopcova, H; Austin, N; Van Brandt, S; Surkyn, M; De Cleyn, M; Vos, A; Rombouts, FJR; Macdonald, G; Moechars, D; Gijsen, HJM; Trabanco, AA	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502599&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155513259	440711184							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51234876	C[C@H]1SC(N)=N[C@@](C)([C@H]1F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C18H18F3N5O2S/c1-9-15(21)18(2,26-17(22)29-9)11-5-10(3-4-12(11)20)25-16(27)13-6-24-14(7-23-13)28-8-19/h3-7,9,15H,8H2,1-2H3,(H2,22,26)(H,25,27)/t9-,15+,18-/m1/s1	JWJQXZNLFNMIHE-AHRODOEDSA-N	50505569	CHEMBL4557670	Beta-secretase 2			 7.1							ChEMBL	10.1021/acs.jmedchem.9b01140	10.7270/Q2CJ8HRN	31549838			Tadano, G; Komano, K; Yoshida, S; Suzuki, S; Nakahara, K; Fuchino, K; Fujimoto, K; Matsuoka, E; Yamamoto, T; Asada, N; Ito, H; Sakaguchi, G; Kanegawa, N; Kido, Y; Ando, S; Fukushima, T; Teisman, A; Urmaliya, V; Dhuyvetter, D; Borghys, H; Van Den Bergh, A; Austin, N; Gijsen, HJM; Yamano, Y; Iso, Y; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505569&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	C83	6JT3	91971958	440714154							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221351	C[C@]1(CCSC(N)=N1)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F	InChI=1S/C17H16F3N5OS/c1-17(4-5-27-16(21)25-17)10-6-9(2-3-11(10)18)24-15(26)13-8-22-12(7-23-13)14(19)20/h2-3,6-8,14H,4-5H2,1H3,(H2,21,25)(H,24,26)/t17-/m0/s1	CVKJPGNYHYLYIO-KRWDZBQOSA-N	50501807	CHEMBL4563915	Beta-secretase 2			 102							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501807&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155559529	440710392							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221352	C[C@@]1(N=C(N)SCC11CCS(=O)(=O)CC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C21H23F2N5O4S2/c1-20(21(11-33-19(24)28-20)4-6-34(30,31)7-5-21)14-8-13(2-3-15(14)23)27-18(29)16-9-26-17(10-25-16)32-12-22/h2-3,8-10H,4-7,11-12H2,1H3,(H2,24,28)(H,27,29)/t20-/m1/s1	DZTJZUAOGBUBNK-HXUWFJFHSA-N	50501808	CHEMBL4465534	Beta-secretase 2			 2090							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501808&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	C7O	6JSZ,6JSN	138454796	440710393							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221354	C[C@@]1(N=C(N)SCC11CCC(F)(F)CC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C22H23F4N5O2S/c1-20(21(11-34-19(27)31-20)4-6-22(25,26)7-5-21)14-8-13(2-3-15(14)24)30-18(32)16-9-29-17(10-28-16)33-12-23/h2-3,8-10H,4-7,11-12H2,1H3,(H2,27,31)(H,30,32)/t20-/m1/s1	KQYDNWCBVYLWOX-HXUWFJFHSA-N	50501810	CHEMBL4443968	Beta-secretase 2		 2000								ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501810&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155516667	440710395							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221363	C[C@]1(CCSC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C17H16F2N4OS/c1-17(6-7-25-16(20)23-17)12-8-11(3-4-13(12)19)22-15(24)14-5-2-10(18)9-21-14/h2-5,8-9H,6-7H2,1H3,(H2,20,23)(H,22,24)/t17-/m0/s1	DILGPRAZNUBLGP-KRWDZBQOSA-N	50501815	CHEMBL4582946	Beta-secretase 2			 14							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501815&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59374702	440710400							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221364	C[C@]1(CCSC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F	InChI=1S/C18H16FN5OS/c1-18(6-7-26-17(21)24-18)13-8-12(3-4-14(13)19)23-16(25)15-5-2-11(9-20)10-22-15/h2-5,8,10H,6-7H2,1H3,(H2,21,24)(H,23,25)/t18-/m0/s1	MKQFGRIUTNJQSW-SFHVURJKSA-N	50501811	CHEMBL4535964	Beta-secretase 2			 21							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501811&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			25115954	440710396							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221365	C[C@]1(CCSC(N)=N1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C17H17F2N5O2S/c1-17(4-5-27-16(20)24-17)11-6-10(2-3-12(11)19)23-15(25)13-7-22-14(8-21-13)26-9-18/h2-3,6-8H,4-5,9H2,1H3,(H2,20,24)(H,23,25)/t17-/m0/s1	BXIRVKRXOFHZBJ-KRWDZBQOSA-N	50501816	CHEMBL4568202	Beta-secretase 2			 78							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501816&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155560600	440710401							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221366	C[C@@]1(N=C(N)SC[C@@H]1c1ccccc1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C23H21F2N5O2S/c1-23(17(12-33-22(26)30-23)14-5-3-2-4-6-14)16-9-15(7-8-18(16)25)29-21(31)19-10-28-20(11-27-19)32-13-24/h2-11,17H,12-13H2,1H3,(H2,26,30)(H,29,31)/t17-,23-/m1/s1	BCDWEYSMCDBNJS-UZUQRXQVSA-N	50501806	CHEMBL4473080	Beta-secretase 2			 28							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501806&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	C6R	6JSE	138857908	440710391							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221367	C[C@@]1(N=C(N)SC[C@H]1c1ccccc1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C23H21F2N5O2S/c1-23(17(12-33-22(26)30-23)14-5-3-2-4-6-14)16-9-15(7-8-18(16)25)29-21(31)19-10-28-20(11-27-19)32-13-24/h2-11,17H,12-13H2,1H3,(H2,26,30)(H,29,31)/t17-,23+/m0/s1	BCDWEYSMCDBNJS-GAJHUEQPSA-N	50501809	CHEMBL4463201	Beta-secretase 2			 13							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501809&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	C7X	6JSF	138857909	440710394							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221368	C[C@@]1(N=C(N)SC[C@@H]1C1CCOCC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C22H25F2N5O3S/c1-22(16(11-33-21(25)29-22)13-4-6-31-7-5-13)15-8-14(2-3-17(15)24)28-20(30)18-9-27-19(10-26-18)32-12-23/h2-3,8-10,13,16H,4-7,11-12H2,1H3,(H2,25,29)(H,28,30)/t16-,22-/m1/s1	PZCOYONDHXLHIX-OPAMFIHVSA-N	50501813	CHEMBL4587362	Beta-secretase 2			 74							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501813&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155566643	440710398							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221369	C[C@@]1(N=C(N)SCC11CC(F)(F)C1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C20H19F4N5O2S/c1-18(19(7-20(23,24)8-19)9-32-17(25)29-18)12-4-11(2-3-13(12)22)28-16(30)14-5-27-15(6-26-14)31-10-21/h2-6H,7-10H2,1H3,(H2,25,29)(H,28,30)/t18-/m1/s1	NHIZASHNRARLRK-GOSISDBHSA-N	50501814	CHEMBL4592239	Beta-secretase 2			 129							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501814&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			126693231	440710399							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221379	C[C@@]1(N=C(N)SCC11CCS(=O)(=O)CC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C21H23F2N5O4S2/c1-20(21(11-33-19(24)28-20)4-6-34(30,31)7-5-21)14-8-13(2-3-15(14)23)27-18(29)16-9-26-17(10-25-16)32-12-22/h2-3,8-10H,4-7,11-12H2,1H3,(H2,24,28)(H,27,29)/t20-/m1/s1	DZTJZUAOGBUBNK-HXUWFJFHSA-N	50501808	CHEMBL4465534	Beta-secretase 2		 1740								ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501808&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	C7O	6JSZ,6JSN	138454796	440710393							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221381	COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CCSC(N)=N1	InChI=1S/C17H18FN5O2S/c1-17(5-6-26-16(19)23-17)11-7-10(3-4-12(11)18)22-15(24)13-8-21-14(25-2)9-20-13/h3-4,7-9H,5-6H2,1-2H3,(H2,19,23)(H,22,24)/t17-/m0/s1	XVSCHNRASRAPMA-KRWDZBQOSA-N	50501819	CHEMBL4561732	Beta-secretase 2			 85							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501819	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501819&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			45255111	440710404							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221383	C[C@@]1(N=C(N)SCC11CCOCC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C21H23F2N5O3S/c1-20(21(4-6-30-7-5-21)11-32-19(24)28-20)14-8-13(2-3-15(14)23)27-18(29)16-9-26-17(10-25-16)31-12-22/h2-3,8-10H,4-7,11-12H2,1H3,(H2,24,28)(H,27,29)/t20-/m1/s1	WFVMDJXIYGUERD-HXUWFJFHSA-N	50501818	CHEMBL4583340	Beta-secretase 2		 479								ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501818&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155565975	440710403							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221386	C[C@@]1(N=C(N)SCC11CCC(F)(F)CC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C22H23F4N5O2S/c1-20(21(11-34-19(27)31-20)4-6-22(25,26)7-5-21)14-8-13(2-3-15(14)24)30-18(32)16-9-29-17(10-28-16)33-12-23/h2-3,8-10H,4-7,11-12H2,1H3,(H2,27,31)(H,30,32)/t20-/m1/s1	KQYDNWCBVYLWOX-HXUWFJFHSA-N	50501810	CHEMBL4443968	Beta-secretase 2			 1660							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501810&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155516667	440710395							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221392	C[C@]1(CCSC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C17H16ClFN4OS/c1-17(6-7-25-16(20)23-17)12-8-11(3-4-13(12)19)22-15(24)14-5-2-10(18)9-21-14/h2-5,8-9H,6-7H2,1H3,(H2,20,23)(H,22,24)/t17-/m0/s1	VVZZZUNCWSTIOI-KRWDZBQOSA-N	50432632	CHEMBL2347211	Beta-secretase 2			 8.7							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432632&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	C6U	6JSG	50938551	164161507		CHEMBL2347211				ZINC34951408	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221393	CO[C@H]1CSC(N)=N[C@]1(C)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C18H19F2N5O3S/c1-18(14(27-2)8-29-17(21)25-18)11-5-10(3-4-12(11)20)24-16(26)13-6-23-15(7-22-13)28-9-19/h3-7,14H,8-9H2,1-2H3,(H2,21,25)(H,24,26)/t14-,18+/m0/s1	MUPBDTQMTBLIBE-KBXCAEBGSA-N	50501812	CHEMBL4451133	Beta-secretase 2			 251							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501812&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155522051	440710397							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221394	C[C@@]1(N=C(N)SCC11CCOCC1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C21H23F2N5O3S/c1-20(21(4-6-30-7-5-21)11-32-19(24)28-20)14-8-13(2-3-15(14)23)27-18(29)16-9-26-17(10-25-16)31-12-22/h2-3,8-10H,4-7,11-12H2,1H3,(H2,24,28)(H,27,29)/t20-/m1/s1	WFVMDJXIYGUERD-HXUWFJFHSA-N	50501818	CHEMBL4583340	Beta-secretase 2			 631							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501818&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155565975	440710403							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51221400	C[C@]1(CCSC(N)=N1)c1cc(NC(=O)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C18H17F4N5O2S/c1-17(4-5-30-16(23)27-17)11-6-10(2-3-12(11)19)26-15(28)13-7-25-14(8-24-13)29-9-18(20,21)22/h2-3,6-8H,4-5,9H2,1H3,(H2,23,27)(H,26,28)/t17-/m0/s1	DIQQTCZQBJWAIV-KRWDZBQOSA-N	50501817	CHEMBL4536643	Beta-secretase 2			 316							ChEMBL	10.1021/acs.jmedchem.9b00309	10.7270/Q22J6G35	31021626			Fujimoto, K; Matsuoka, E; Asada, N; Tadano, G; Yamamoto, T; Nakahara, K; Fuchino, K; Ito, H; Kanegawa, N; Moechars, D; Gijsen, HJM; Kusakabe, KI	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501817&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			59250417	440710402							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917065	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1ccccc1F	InChI=1S/C16H21FN2O3S/c1-10-8-13-16(9-22-10,11-6-4-5-7-12(11)17)19-14(18)15(2,3)23(13,20)21/h4-7,10,13H,8-9H2,1-3H3,(H2,18,19)/t10-,13+,16+/m0/s1	DMEDVHXVIZMNTO-OWRWGESLSA-N	448194	US10689401, EX 1::US11008338, Example 1	Beta-secretase 2		 72.5								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448194&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406873	440710205							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917067	C[C@@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1ccccc1F	InChI=1S/C16H21FN2O3S/c1-10-8-13-16(9-22-10,11-6-4-5-7-12(11)17)19-14(18)15(2,3)23(13,20)21/h4-7,10,13H,8-9H2,1-3H3,(H2,18,19)/t10-,13-,16-/m1/s1	DMEDVHXVIZMNTO-CKUKBARFSA-N	448195	US10689401, EX 2::US11008338, Example 2	Beta-secretase 2		 6259								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448195&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406936	440710206							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917069	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Br)ccc1F	InChI=1S/C16H20BrFN2O3S/c1-9-6-13-16(8-23-9,11-7-10(17)4-5-12(11)18)20-14(19)15(2,3)24(13,21)22/h4-5,7,9,13H,6,8H2,1-3H3,(H2,19,20)/t9-,13+,16+/m0/s1	PWHVSROCXLHTFE-LQBHMHGISA-N	448196	US10689401, EX 3::US11008338, Example 3	Beta-secretase 2		 399								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448196&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406872	440710207							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917071	CC(C)COc1ccc(F)c(c1)[C@]12CO[C@@H](C)C[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C20H29FN2O4S/c1-12(2)10-26-14-6-7-16(21)15(9-14)20-11-27-13(3)8-17(20)28(24,25)19(4,5)18(22)23-20/h6-7,9,12-13,17H,8,10-11H2,1-5H3,(H2,22,23)/t13-,17+,20+/m0/s1	QUQKAGGARNDCIR-WSXQUGQNSA-N	448197	US10689401, EX 4::US11008338, Example 4	Beta-secretase 2		 31.6								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448197&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406939	440710208							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917073	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C21H23F2N3O4S/c1-12-9-17-21(11-29-12,26-19(24)20(2,3)31(17,27)28)14-10-13(6-7-15(14)22)30-18-16(23)5-4-8-25-18/h4-8,10,12,17H,9,11H2,1-3H3,(H2,24,26)/t12-,17+,21+/m0/s1	NUTYXXXZWVAGHN-LKNMKHRSSA-N	448199	US10689401, EX 5::US11008338, Example 5	Beta-secretase 2		 4.90								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448199&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406870	440710210							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917075	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C22H23FN4O4S/c1-13-8-18-22(12-30-13,27-20(25)21(2,3)32(18,28)29)16-10-15(4-5-17(16)23)31-19-9-14(11-24)6-7-26-19/h4-7,9-10,13,18H,8,12H2,1-3H3,(H2,25,27)/t13-,18+,22+/m0/s1	IJEGIKZGGLFERE-PFDOBSCMSA-N	448202	US10689401, EX 6	Beta-secretase 2		 19.2								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448202&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406883	440710213							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917077	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C21H22F3N3O4S/c1-11-6-17-21(10-30-11,27-19(25)20(2,3)32(17,28)29)14-8-13(4-5-15(14)23)31-18-16(24)7-12(22)9-26-18/h4-5,7-9,11,17H,6,10H2,1-3H3,(H2,25,27)/t11-,17+,21+/m0/s1	SDKJCGRZSMGSBT-PPJNFFCYSA-N	448203	US10689401, EX 7::US11008338, Example 7	Beta-secretase 2		 28.9								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448203&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406927	440710214							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917079	C[C@@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F	InChI=1S/C20H27FN2O4S/c1-12-8-17-20(11-27-12,23-18(22)19(2,3)28(17,24)25)15-9-14(6-7-16(15)21)26-10-13-4-5-13/h6-7,9,12-13,17H,4-5,8,10-11H2,1-3H3,(H2,22,23)/t12-,17-,20-/m1/s1	SGIXEMDUXNNPQL-WYAVIUHXSA-N	448204	US10689401, EX 8::US11008338, Example 8	Beta-secretase 2		 1181								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448204&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406906	440710215							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917081	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F	InChI=1S/C20H27FN2O4S/c1-12-8-17-20(11-27-12,23-18(22)19(2,3)28(17,24)25)15-9-14(6-7-16(15)21)26-10-13-4-5-13/h6-7,9,12-13,17H,4-5,8,10-11H2,1-3H3,(H2,22,23)/t12-,17+,20+/m0/s1	SGIXEMDUXNNPQL-LCIZUOBNSA-N	448205	US10689401, EX 9::US11008338, Example 9	Beta-secretase 2		 11.4								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448205&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406935	440710216							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917083	COc1ccc(F)c(c1)[C@]12CO[C@@H](C)C[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C17H23FN2O4S/c1-10-7-14-17(9-24-10,12-8-11(23-4)5-6-13(12)18)20-15(19)16(2,3)25(14,21)22/h5-6,8,10,14H,7,9H2,1-4H3,(H2,19,20)/t10-,14+,17+/m0/s1	QVNIHLNCRLCQBA-NCAQKEMTSA-N	448206	US10689401, EX 10::US11008338, Example 10	Beta-secretase 2		 249								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448206&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406940	440710217							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917085	COc1ccc(F)c(c1)[C@]12CO[C@H](C)C[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C17H23FN2O4S/c1-10-7-14-17(9-24-10,12-8-11(23-4)5-6-13(12)18)20-15(19)16(2,3)25(14,21)22/h5-6,8,10,14H,7,9H2,1-4H3,(H2,19,20)/t10-,14-,17-/m1/s1	QVNIHLNCRLCQBA-LGFNAOKASA-N	448207	US10689401, EX 11::US11008338, Example 11	Beta-secretase 2		 8396								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448207&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406932	440710218							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917087	COc1ccc(F)c(c1)[C@]12CO[C@H](C[C@H]1S(=O)(=O)C(C)(C)C(=N)N2)c1ccc(F)cc1	InChI=1S/C22H24F2N2O4S/c1-21(2)20(25)26-22(16-10-15(29-3)8-9-17(16)24)12-30-18(11-19(22)31(21,27)28)13-4-6-14(23)7-5-13/h4-10,18-19H,11-12H2,1-3H3,(H2,25,26)/t18-,19-,22-/m1/s1	QHXIKGDWSQXRCG-WOIUINJBSA-N	448208	US10689401, EX 12::US11008338, Example 12	Beta-secretase 2		 96.3								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448208&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406933	440710219							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917089	CC1(C)C(=N)N[C@]2(CO[C@H](C[C@H]2S1(=O)=O)c1ccc(F)cc1)c1cc(OCC2CC2)ccc1F	InChI=1S/C25H28F2N2O4S/c1-24(2)23(28)29-25(19-11-18(9-10-20(19)27)32-13-15-3-4-15)14-33-21(12-22(25)34(24,30)31)16-5-7-17(26)8-6-16/h5-11,15,21-22H,3-4,12-14H2,1-2H3,(H2,28,29)/t21-,22-,25-/m1/s1	IUWNLGMMWSCZQJ-TZBSWOFLSA-N	448209	US10689401, EX 13::US11008338, Example 13	Beta-secretase 2		 11.7								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448209&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137419350	440710220							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917091	CC1(C)C(=N)N[C@]2(CO[C@H](C[C@H]2S1(=O)=O)c1ccc(F)cc1)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C26H24F3N3O4S/c1-25(2)24(30)32-26(18-12-17(9-10-19(18)28)36-23-20(29)4-3-11-31-23)14-35-21(13-22(26)37(25,33)34)15-5-7-16(27)8-6-15/h3-12,21-22H,13-14H2,1-2H3,(H2,30,32)/t21-,22-,26-/m1/s1	AHJOKRHJPSGPFR-XLGIIRLISA-N	448210	US10689401, EX 14::US11008338, Example 14	Beta-secretase 2		 1.90								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448210&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			130303031	440710221							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917093	CC1(C)C(=N)N[C@]2(CO[C@H](C[C@H]2S1(=O)=O)c1ccc(F)cc1)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C27H24F2N4O4S/c1-26(2)25(31)33-27(15-36-22(13-23(27)38(26,34)35)17-3-5-18(28)6-4-17)20-12-19(7-8-21(20)29)37-24-11-16(14-30)9-10-32-24/h3-12,22-23H,13,15H2,1-2H3,(H2,31,33)/t22-,23-,27-/m1/s1	NLARUVVSXLNQML-AZSVPQILSA-N	448211	US10689401, EX 15	Beta-secretase 2		 19.8								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448211&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406903	440710222							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917095	COc1ccc(F)c(c1)[C@]12CO[C@@H](CO)C[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C17H23FN2O5S/c1-16(2)15(19)20-17(12-6-10(24-3)4-5-13(12)18)9-25-11(8-21)7-14(17)26(16,22)23/h4-6,11,14,21H,7-9H2,1-3H3,(H2,19,20)/t11-,14-,17-/m1/s1	GBUJBBUXZUVCEF-JDSLSITLSA-N	448212	US10689401, EX 16::US11008338, Example 16	Beta-secretase 2		 2020								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448212&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406937	440710223							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917097	CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1ccccc1F	InChI=1S/C17H23FN2O3S/c1-15(2)9-13-17(10-23-15,11-7-5-6-8-12(11)18)20-14(19)16(3,4)24(13,21)22/h5-8,13H,9-10H2,1-4H3,(H2,19,20)/t13-,17-/m1/s1	HNBPJKODDGJDLI-CXAGYDPISA-N	448214	US10689401, EX 17::US11008338, Example 17	Beta-secretase 2		 293								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448214&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406905	440710225							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917099	CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C22H25F2N3O4S/c1-20(2)11-17-22(12-30-20,27-19(25)21(3,4)32(17,28)29)14-10-13(7-8-15(14)23)31-18-16(24)6-5-9-26-18/h5-10,17H,11-12H2,1-4H3,(H2,25,27)/t17-,22-/m1/s1	AWNVVJFOKZAZSC-VGOFRKELSA-N	448215	US10689401, EX 18::US11008338, Example 18	Beta-secretase 2		 42.2								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448215&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137419196	440710226							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917101	CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2cc(ccn2)C#N)ccc1F	InChI=1S/C23H25FN4O4S/c1-21(2)11-18-23(13-31-21,28-20(26)22(3,4)33(18,29)30)16-10-15(5-6-17(16)24)32-19-9-14(12-25)7-8-27-19/h5-10,18H,11,13H2,1-4H3,(H2,26,28)/t18-,23-/m1/s1	OFAXBKOSZSBJLJ-WZONZLPQSA-N	448217	US10689401, EX 19	Beta-secretase 2		 65.2								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448217&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406886	440710228							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917103	CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C22H24F3N3O4S/c1-20(2)9-17-22(11-31-20,28-19(26)21(3,4)33(17,29)30)14-8-13(5-6-15(14)24)32-18-16(25)7-12(23)10-27-18/h5-8,10,17H,9,11H2,1-4H3,(H2,26,28)/t17-,22-/m1/s1	VNRVMHBCWPYCJV-VGOFRKELSA-N	448218	US10689401, EX 20::US11008338, Example 20	Beta-secretase 2		 102								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137419188	440710229							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917105	CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2cc(F)cnc2F)ccc1F	InChI=1S/C22H24F3N3O4S/c1-20(2)9-17-22(11-31-20,28-19(26)21(3,4)33(17,29)30)14-8-13(5-6-15(14)24)32-16-7-12(23)10-27-18(16)25/h5-8,10,17H,9,11H2,1-4H3,(H2,26,28)/t17-,22-/m1/s1	PQHKPNMCPHYYOU-VGOFRKELSA-N	448219	US10689401, EX 21::US11008338, Example 21	Beta-secretase 2		 88.0								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448219&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137419186	440710230							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917107	CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OCC2CC2)ccc1F	InChI=1S/C21H29FN2O4S/c1-19(2)10-17-21(12-28-19,24-18(23)20(3,4)29(17,25)26)15-9-14(7-8-16(15)22)27-11-13-5-6-13/h7-9,13,17H,5-6,10-12H2,1-4H3,(H2,23,24)/t17-,21-/m1/s1	WCIHGKODJJUKIZ-DYESRHJHSA-N	448220	US10689401, EX 22::US11008338, Example 22	Beta-secretase 2		 35.6								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137419187	440710231							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917109	CC(C)COc1ccc(F)c(c1)[C@]12COC(C)(C)C[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C21H31FN2O4S/c1-13(2)11-27-14-7-8-16(22)15(9-14)21-12-28-19(3,4)10-17(21)29(25,26)20(5,6)18(23)24-21/h7-9,13,17H,10-12H2,1-6H3,(H2,23,24)/t17-,21-/m1/s1	HLHFHJHBERJEIK-DYESRHJHSA-N	448221	US10689401, EX 23::US11008338, Example 23	Beta-secretase 2		 66.7								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137419199	440710232							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917111	CC1(C)C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(OC2CCC2)ccc1F	InChI=1S/C21H29FN2O4S/c1-19(2)11-17-21(12-27-19,24-18(23)20(3,4)29(17,25)26)15-10-14(8-9-16(15)22)28-13-6-5-7-13/h8-10,13,17H,5-7,11-12H2,1-4H3,(H2,23,24)/t17-,21-/m1/s1	WWOMLEHPHXLZHM-DYESRHJHSA-N	448222	US10689401, EX 24::US11008338, Example 24	Beta-secretase 2		 109								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448222&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137419198	440710233							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
917113	CC(C)[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1ccccc1F	InChI=1S/C18H25FN2O3S/c1-11(2)14-9-15-18(10-24-14,12-7-5-6-8-13(12)19)21-16(20)17(3,4)25(15,22)23/h5-8,11,14-15H,9-10H2,1-4H3,(H2,20,21)/t14-,15-,18-/m1/s1	OQFPZOUKNLLKGE-IIDMSEBBSA-N	448223	US10689401, EX 25::US11008338, Example 25	Beta-secretase 2		 195								US Patent		10.7270/Q2N87DS6		aid1804514	US10689401	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406929	440710234							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51277123	COc1ccc(Cc2cnc(OC)c3C[C@@]4(N=C(N)SC[C@@H]4Cc23)c2ccc(F)cc2F)cc1	InChI=1S/C26H25F2N3O2S/c1-32-19-6-3-15(4-7-19)9-16-13-30-24(33-2)21-12-26(22-8-5-18(27)11-23(22)28)17(10-20(16)21)14-34-25(29)31-26/h3-8,11,13,17H,9-10,12,14H2,1-2H3,(H2,29,31)/t17-,26-/m0/s1	XFIBJZIUSNOOSS-QLXKLKPCSA-N	50521246	CHEMBL4526561	Beta-secretase 2			 79							ChEMBL	10.1021/acsmedchemlett.8b00545	10.7270/Q2F76GZP	30655936			Blass, BE	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			154031827	440729828							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51277125	COc1ncc(CC2CCOCC2)c2C[C@H]3CSC(N)=N[C@]3(Cc12)c1ccc(F)cc1F	InChI=1S/C24H27F2N3O2S/c1-30-22-19-11-24(20-3-2-17(25)10-21(20)26)16(13-32-23(27)29-24)9-18(19)15(12-28-22)8-14-4-6-31-7-5-14/h2-3,10,12,14,16H,4-9,11,13H2,1H3,(H2,27,29)/t16-,24-/m0/s1	HOIGPFAVELSPMQ-FYSMJZIKSA-N	50510815	CHEMBL4530208	Beta-secretase 2			 6.6							ChEMBL	10.1021/acsmedchemlett.8b00545	10.7270/Q2F76GZP	30655936			Blass, BE	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510815&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			154031826	440719397							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51277127	COc1ncc(Cc2c(C)noc2C)c2C[C@H]3CSC(N)=N[C@]3(Cc12)c1ccc(F)cc1F	InChI=1S/C24H24F2N4O2S/c1-12-17(13(2)32-30-12)6-14-10-28-22(31-3)19-9-24(20-5-4-16(25)8-21(20)26)15(7-18(14)19)11-33-23(27)29-24/h4-5,8,10,15H,6-7,9,11H2,1-3H3,(H2,27,29)/t15-,24-/m0/s1	WDOXRAVWGMXDFC-OWJWWREXSA-N	50521247	CHEMBL4520734	Beta-secretase 2			 44							ChEMBL	10.1021/acsmedchemlett.8b00545	10.7270/Q2F76GZP	30655936			Blass, BE	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155542315	440729829							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51277129	COc1ncc(Cc2c(C)cccc2C)c2C[C@H]3CSC(N)=N[C@]3(Cc12)c1ccc(F)cc1F	InChI=1S/C27H27F2N3OS/c1-15-5-4-6-16(2)20(15)9-17-13-31-25(33-3)22-12-27(23-8-7-19(28)11-24(23)29)18(10-21(17)22)14-34-26(30)32-27/h4-8,11,13,18H,9-10,12,14H2,1-3H3,(H2,30,32)/t18-,27-/m0/s1	WVRKURQZXYBXNI-MYUZEXMDSA-N	50521248	CHEMBL4549145	Beta-secretase 2			 275							ChEMBL	10.1021/acsmedchemlett.8b00545	10.7270/Q2F76GZP	30655936			Blass, BE	Temple University School of Pharmacy	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155548834	440729830							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334645	C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1	InChI=1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1	MJQMRGWYPNIERM-HNNXBMFYSA-N	50012632	CHEMBL2333941	Beta-secretase 2			 288							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012632&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	4B2	4YBI	44251605	103924885		CHEMBL2333941				ZINC18098141	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334646	NC1=N[C@]2(COC[C@H]2CS1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F	InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/s1	NIDRNVHMMDAAIK-YPMLDQLKSA-N	50012647	CHEMBL2396989	Beta-secretase 2			 10							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50012647	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50012647&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	3YS	4X7I	49837968	103924900		CHEMBL2396989				ZINC29415484	1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334647	NC1=N[C@]2(COC[C@H]2CS1)[C@H]1C[C@@H]1NC(=O)c1ccc(F)cn1	InChI=1S/C15H17FN4O2S/c16-9-1-2-11(18-4-9)13(21)19-12-3-10(12)15-7-22-5-8(15)6-23-14(17)20-15/h1-2,4,8,10,12H,3,5-7H2,(H2,17,20)(H,19,21)/t8-,10-,12-,15-/m0/s1	OWWIYTVWTQBRDL-FGAILIKWSA-N	50540163	CHEMBL4637568	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540163&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	QJJ	6UVP	145704715	442141726							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334648	NC1=N[C@]2(COC[C@H]2CS1)[C@@H]1C[C@H]1C(=O)Nc1ccc(F)cn1	InChI=1S/C15H17FN4O2S/c16-9-1-2-12(18-4-9)19-13(21)10-3-11(10)15-7-22-5-8(15)6-23-14(17)20-15/h1-2,4,8,10-11H,3,5-7H2,(H2,17,20)(H,18,19,21)/t8-,10+,11+,15-/m0/s1	BPFYCHBMLLBUKA-DOKDZLDGSA-N	50540164	CHEMBL4640948	Beta-secretase 2			 73600							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540164&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156015617	442141727							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334649	CCNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=N2	InChI=1S/C12H19N3O2S/c1-2-14-10(16)8-3-9(8)12-6-17-4-7(12)5-18-11(13)15-12/h7-9H,2-6H2,1H3,(H2,13,15)(H,14,16)/t7-,8+,9+,12-/m0/s1	VAPJUXNDIXGLMR-HAYRHPOISA-N	50540165	CHEMBL4637913	Beta-secretase 2			 104000							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540165&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156011383	442141728							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334650	CCCNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=N2	InChI=1S/C13H21N3O2S/c1-2-3-15-11(17)9-4-10(9)13-7-18-5-8(13)6-19-12(14)16-13/h8-10H,2-7H2,1H3,(H2,14,16)(H,15,17)/t8-,9+,10+,13-/m0/s1	AZMITPYXDXQIOX-WTBMIXGQSA-N	50540166	CHEMBL4636311	Beta-secretase 2			 24600							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540166&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156013660	442141729							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334651	CCCCNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=N2	InChI=1S/C14H23N3O2S/c1-2-3-4-16-12(18)10-5-11(10)14-8-19-6-9(14)7-20-13(15)17-14/h9-11H,2-8H2,1H3,(H2,15,17)(H,16,18)/t9-,10+,11+,14-/m0/s1	WVAFMFLAAGBATC-OXIWPEFWSA-N	50540167	CHEMBL4642463	Beta-secretase 2			 7330							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540167&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	QJV	6UVV	145704717	442141730							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334652	C[C@@H]1C[C@H]1CNC(=O)[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=N2	InChI=1S/C15H23N3O2S/c1-8-2-9(8)4-17-13(19)11-3-12(11)15-7-20-5-10(15)6-21-14(16)18-15/h8-12H,2-7H2,1H3,(H2,16,18)(H,17,19)/t8-,9+,10+,11-,12-,15+/m1/s1	FKPBYKKZZCOMKI-MIDHOLSSSA-N	50540168	CHEMBL4644249	Beta-secretase 2			 1580							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540168&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	QJP	6UVY	145704718	442141731							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334653	CCCCC(=O)N[C@@H]1C[C@H]1[C@]12COC[C@H]1CSC(N)=N2	InChI=1S/C14H23N3O2S/c1-2-3-4-12(18)16-11-5-10(11)14-8-19-6-9(14)7-20-13(15)17-14/h9-11H,2-8H2,1H3,(H2,15,17)(H,16,18)/t9-,10+,11+,14-/m0/s1	OSYFHIQBMUKDPZ-OXIWPEFWSA-N	50540169	CHEMBL4648644	Beta-secretase 2			>100000							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540169&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156020065	442141732							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334654	CCCCNC(=O)[C@@H]1C[C@H]1[C@]12CN(C[C@H]1CSC(N)=N2)c1ncccn1	InChI=1S/C18H26N6OS/c1-2-3-5-20-15(25)13-8-14(13)18-11-24(17-21-6-4-7-22-17)9-12(18)10-26-16(19)23-18/h4,6-7,12-14H,2-3,5,8-11H2,1H3,(H2,19,23)(H,20,25)/t12-,13+,14+,18-/m0/s1	QJJBLKYNQOSIHJ-LWGWVAHUSA-N	50540170	CHEMBL4636286	Beta-secretase 2			 44							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540170&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156013710	442141733							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334655	C[C@@H]1C[C@H]1CNC(=O)[C@@H]1C[C@H]1[C@]12CN(C[C@H]1CSC(N)=N2)c1ncccn1	InChI=1S/C19H26N6OS/c1-11-5-12(11)7-23-16(26)14-6-15(14)19-10-25(18-21-3-2-4-22-18)8-13(19)9-27-17(20)24-19/h2-4,11-15H,5-10H2,1H3,(H2,20,24)(H,23,26)/t11-,12+,13+,14-,15-,19+/m1/s1	UKXLLHCQBVONES-MPDRSUQMSA-N	50540171	CHEMBL4643727	Beta-secretase 2			 22							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540171&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	QKA	6UWP	145704719	442141734							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51334656	C[C@@H]1C[C@H]1COC(C)(C)[C@@H]1C[C@H]1[C@]12CN(C[C@H]1CSC(N)=N2)c1ncccn1	InChI=1S/C21H31N5OS/c1-13-7-14(13)10-27-20(2,3)16-8-17(16)21-12-26(19-23-5-4-6-24-19)9-15(21)11-28-18(22)25-21/h4-6,13-17H,7-12H2,1-3H3,(H2,22,25)/t13-,14+,15+,16-,17-,21+/m1/s1	BFGQEVKVRRYAQC-IFEDNLKFSA-N	50540172	CHEMBL4637426	Beta-secretase 2			 5.3							ChEMBL	10.1016/j.bmc.2019.115194	10.7270/Q2B56P8K	31786008			Winneroski, LL; Erickson, JA; Green, SJ; Lopez, JE; Stout, SL; Porter, WJ; Timm, DE; Audia, JE; Barberis, M; Beck, JP; Boggs, LN; Borders, AR; Boyer, RD; Brier, RA; Hembre, EJ; Hendle, J; Garcia-Losada, P; Minguez, JM; Mathes, BM; May, PC; Monk, SA; Rankovic, Z; Shi, Y; Watson, BM; Yang, Z; Mergott, DJ	Eli Lilly and Company	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540172&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	QK7	6UWV	145704720	442141735							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993501	C[C@]1(C=CSC(N)=N1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H14F2N4S/c1-19(6-7-26-18(23)25-19)14-8-12(2-4-15(14)20)9-16(21)17-5-3-13(10-22)11-24-17/h2-9,11H,1H3,(H2,23,25)/b16-9-/t19-/m0/s1	WKOIVUXVVOAIDL-QHVUTBCBSA-N	477881	US10889579, Example 101	Beta-secretase 2			 601							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477881&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126429	442137495							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51347676	C[C@H]1C[C@H]2CC(F)(F)C(N)=N[C@]2(CO1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C21H21F4N5O3/c1-11-4-12-6-21(24,25)19(26)30-20(12,9-32-11)14-5-13(2-3-15(14)23)29-18(31)16-7-28-17(8-27-16)33-10-22/h2-3,5,7-8,11-12H,4,6,9-10H2,1H3,(H2,26,30)(H,29,31)/t11-,12-,20-/m0/s1	QQHWYFAIJDVZQX-PVUDRZGPSA-N	50545178	CHEMBL4648883	Beta-secretase 2			 6.8							ChEMBL	10.1016/j.bmcl.2020.126999	10.7270/Q2W95DRH	32089426			Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50545178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50545178&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			146673158	442110989							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51347681	NC1=N[C@]2(CO[C@@H](CF)C[C@H]2CC1(F)F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C21H20F5N5O3/c22-6-13-3-11-5-21(25,26)19(27)31-20(11,9-33-13)14-4-12(1-2-15(14)24)30-18(32)16-7-29-17(8-28-16)34-10-23/h1-2,4,7-8,11,13H,3,5-6,9-10H2,(H2,27,31)(H,30,32)/t11-,13+,20-/m0/s1	YTDOAMKMBQFAAC-SCLGINMFSA-N	50545179	CHEMBL4636350	Beta-secretase 2			 8.9							ChEMBL	10.1016/j.bmcl.2020.126999	10.7270/Q2W95DRH	32089426			Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50545179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50545179&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156011645	442110990							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993504	C[C@]1(CCSC(N)=N1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C18H16ClF2N3S/c1-18(6-7-25-17(22)24-18)13-8-11(2-4-14(13)20)9-15(21)16-5-3-12(19)10-23-16/h2-5,8-10H,6-7H2,1H3,(H2,22,24)/b15-9-/t18-/m0/s1	SUXMDOZZNWAJIB-YHTSIIMFSA-N	477882	US10889579, Example 102	Beta-secretase 2			 64.0							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477882&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125965	442137496							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993507	C[C@]1(CCSC(N)=N1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H16F2N4S/c1-19(6-7-26-18(23)25-19)14-8-12(2-4-15(14)20)9-16(21)17-5-3-13(10-22)11-24-17/h2-5,8-9,11H,6-7H2,1H3,(H2,23,25)/b16-9-/t19-/m0/s1	OEEHPGXMFVJORU-QHVUTBCBSA-N	477883	US10889579, Example 103	Beta-secretase 2			 482							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477883&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125999	442137497							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993510	COC(=O)[C@H]1C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H18ClF2N3O2S/c1-20(9-17(18(27)28-2)29-19(24)26-20)13-7-11(3-5-14(13)22)8-15(23)16-6-4-12(21)10-25-16/h3-8,10,17H,9H2,1-2H3,(H2,24,26)/b15-8-/t17-,20+/m1/s1	VIAPZLCTMVEPSN-YETOEZFSSA-N	477884	(4S,6R)-methyl 2-amino-4-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate; and::US10889579, Example 104	Beta-secretase 2			 185							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477884&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126073	442137498							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993513	COC(=O)[C@@H]1C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H18ClF2N3O2S/c1-20(9-17(18(27)28-2)29-19(24)26-20)13-7-11(3-5-14(13)22)8-15(23)16-6-4-12(21)10-25-16/h3-8,10,17H,9H2,1-2H3,(H2,24,26)/b15-8-/t17-,20-/m0/s1	VIAPZLCTMVEPSN-DVQXZNDESA-N	477885	US10889579, Example 105	Beta-secretase 2			 49.0							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477885&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126033	442137499							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993516	COC(=O)[C@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H20ClF2N3O2S/c1-20(11-21(2,18(28)29-3)30-19(25)27-20)14-8-12(4-6-15(14)23)9-16(24)17-7-5-13(22)10-26-17/h4-10H,11H2,1-3H3,(H2,25,27)/b16-9-/t20-,21-/m0/s1	BERWNTPMLOPRFA-ZLHQPFQKSA-N	477886	(4S,6S)-methyl 2-amino-4-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate; and::US10889579, Example 106	Beta-secretase 2			 75.0							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477886&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125405	442137500							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993519	COC(=O)[C@@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H20ClF2N3O2S/c1-20(11-21(2,18(28)29-3)30-19(25)27-20)14-8-12(4-6-15(14)23)9-16(24)17-7-5-13(22)10-26-17/h4-10H,11H2,1-3H3,(H2,25,27)/b16-9-/t20-,21+/m0/s1	BERWNTPMLOPRFA-MUKCZTLISA-N	477887	US10889579, Example 107	Beta-secretase 2			 90.0							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477887&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125995	442137501							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993522	COC(=O)[C@@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H20F2N4O2S/c1-21(12-22(2,19(29)30-3)31-20(26)28-21)15-8-13(4-6-16(15)23)9-17(24)18-7-5-14(10-25)11-27-18/h4-9,11H,12H2,1-3H3,(H2,26,28)/b17-9-/t21-,22+/m0/s1	MAERFSXIYMAPNB-PWCMVGRQSA-N	477888	(4S,6R)-methyl 2-amino-4-(5-((Z)-2-(5-cyanopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazine-6-carboxylate; and::US10889579, Example 108	Beta-secretase 2			 231							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477888&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126030	442137502							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993525	COC(=O)[C@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H20F2N4O2S/c1-21(12-22(2,19(29)30-3)31-20(26)28-21)15-8-13(4-6-16(15)23)9-17(24)18-7-5-14(10-25)11-27-18/h4-9,11H,12H2,1-3H3,(H2,26,28)/b17-9-/t21-,22-/m0/s1	MAERFSXIYMAPNB-UHEHGDELSA-N	477889	US10889579, Example 109	Beta-secretase 2			 281							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477889&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126498	442137503							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993528	C[C@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)C(=O)N1CCOCC1	InChI=1S/C25H25F2N5O2S/c1-24(15-25(2,35-23(29)31-24)22(33)32-7-9-34-10-8-32)18-11-16(3-5-19(18)26)12-20(27)21-6-4-17(13-28)14-30-21/h3-6,11-12,14H,7-10,15H2,1-2H3,(H2,29,31)/b20-12-/t24-,25-/m0/s1	QBRVMFURZXJSCP-PQLPFPTISA-N	477890	US10889579, Example 110	Beta-secretase 2			 130							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477890&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126489	442137504							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993531	C[C@@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)C(=O)N1CCOCC1	InChI=1S/C25H25F2N5O2S/c1-24(15-25(2,35-23(29)31-24)22(33)32-7-9-34-10-8-32)18-11-16(3-5-19(18)26)12-20(27)21-6-4-17(13-28)14-30-21/h3-6,11-12,14H,7-10,15H2,1-2H3,(H2,29,31)/b20-12-/t24-,25+/m0/s1	QBRVMFURZXJSCP-QKYCXKCASA-N	477891	US10889579, Example 111	Beta-secretase 2			 1470							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477891&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126058	442137505							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993534	CNC(=O)[C@@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C23H23F2N5O2S/c1-5-8-32-19-12-28-18(11-29-19)17(25)10-14-6-7-16(24)15(9-14)22(2)13-23(3,20(31)27-4)33-21(26)30-22/h1,6-7,9-12H,8,13H2,2-4H3,(H2,26,30)(H,27,31)/b17-10-/t22-,23+/m0/s1	DUXJJGZUZXKWAW-MHTWHAOXSA-N	477892	(4S,6R)-2-amino-4-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2-propyn-1-yloxy)-2-pyrazinyl)ethenyl)phenyl)-N,4,6-trimethyl-5,6-dihydro-4H-1,3-thiazine-6-carboxamide; and::US10889579, Example 112	Beta-secretase 2			 1305							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477892&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126031	442137506							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993537	CNC(=O)[C@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C23H23F2N5O2S/c1-5-8-32-19-12-28-18(11-29-19)17(25)10-14-6-7-16(24)15(9-14)22(2)13-23(3,20(31)27-4)33-21(26)30-22/h1,6-7,9-12H,8,13H2,2-4H3,(H2,26,30)(H,27,31)/b17-10-/t22-,23-/m0/s1	DUXJJGZUZXKWAW-WJFVXKAHSA-N	477893	US10889579, Example 113	Beta-secretase 2			 835							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477893&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126076	442137507							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993540	C[C@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F)C(=O)N1CCOCC1	InChI=1S/C26H27F2N5O3S/c1-4-9-36-22-15-30-21(14-31-22)20(28)13-17-5-6-19(27)18(12-17)25(2)16-26(3,37-24(29)32-25)23(34)33-7-10-35-11-8-33/h1,5-6,12-15H,7-11,16H2,2-3H3,(H2,29,32)/b20-13-/t25-,26-/m0/s1	IOFNYKVZLKYNAL-LNBNGDJBSA-N	477894	US10889579, Example 114	Beta-secretase 2			 358							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477894&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126049	442137508							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993543	C[C@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F)C(=O)NCC(F)F	InChI=1S/C24H23F4N5O2S/c1-4-7-35-20-12-30-18(10-31-20)17(26)9-14-5-6-16(25)15(8-14)23(2)13-24(3,36-22(29)33-23)21(34)32-11-19(27)28/h1,5-6,8-10,12,19H,7,11,13H2,2-3H3,(H2,29,33)(H,32,34)/b17-9-/t23-,24-/m0/s1	IHVUSAHOCXOFDW-QTBRSPPKSA-N	477895	US10889579, Example 115	Beta-secretase 2			 760							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477895&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126491	442137509							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993546	CNC(=O)[C@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H21F2N5OS/c1-21(12-22(2,19(30)27-3)31-20(26)29-21)15-8-13(4-6-16(15)23)9-17(24)18-7-5-14(10-25)11-28-18/h4-9,11H,12H2,1-3H3,(H2,26,29)(H,27,30)/b17-9-/t21-,22-/m0/s1	QJKFEJWUIZULMF-UHEHGDELSA-N	477896	US10889579, Example 116	Beta-secretase 2			 560							US Patent		10.7270/Q241715H		aid1805173	US10889579	Bourbeau, MP; Harrington, PE; Liu, Q	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477896&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125408	442137510							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993549	NC1=N[C@@](CF)([C@@H]2C[C@]2(CO)S1)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C21H16F2N4OS/c22-11-21(18-8-20(18,12-28)29-19(25)27-21)16-7-13(3-6-17(16)23)1-4-15-5-2-14(9-24)10-26-15/h2-3,5-7,10,18,28H,8,11-12H2,(H2,25,27)/t18-,20-,21-/m1/s1	ZGAHEVILJKGEED-HMXCVIKNSA-N	477897	6-((3-((1S,5S,6S)-3-amino-5-(fluoromethyl)-1-(hydroxymethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 100	Beta-secretase 2			 4550							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477897&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328469	442137511							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993552	NC1=N[C@@](CF)([C@@H]2C[C@]2(CF)S1)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C21H15F3N4S/c22-11-20-8-18(20)21(12-23,28-19(26)29-20)16-7-13(3-6-17(16)24)1-4-15-5-2-14(9-25)10-27-15/h2-3,5-7,10,18H,8,11-12H2,(H2,26,28)/t18-,20-,21-/m1/s1	SDRBUXDDHNLJGX-HMXCVIKNSA-N	477898	6-((3-((1S,5S,6S)-3-amino-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 101	Beta-secretase 2			 6040							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477898&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126391	442137512							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993555	NC1=N[C@@](CF)([C@@H]2C[C@]2(CF)S1)c1cc(ccc1F)C#Cc1ccc(Cl)cn1	InChI=1S/C20H15ClF3N3S/c21-13-3-5-14(26-9-13)4-1-12-2-6-16(24)15(7-12)20(11-23)17-8-19(17,10-22)28-18(25)27-20/h2-3,5-7,9,17H,8,10-11H2,(H2,25,27)/t17-,19-,20-/m1/s1	FAQNBNVGHSOMNY-MISYRCLQSA-N	477899	(1S,5S,6S)-5-(5-((5-chloropyridin-2-yl)ethynyl)-2-fluorophenyl)-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 102	Beta-secretase 2			 445							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477899&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			150128065	442137513							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993558	NC1=N[C@@](CF)([C@@H]2C[C@]2(CF)S1)c1cc(ccc1F)C#Cc1cnc(cn1)C#N	InChI=1S/C20H14F3N5S/c21-10-19-6-17(19)20(11-22,28-18(25)29-19)15-5-12(2-4-16(15)23)1-3-13-8-27-14(7-24)9-26-13/h2,4-5,8-9,17H,6,10-11H2,(H2,25,28)/t17-,19-,20-/m1/s1	SFMCZNIJMMCWAL-MISYRCLQSA-N	477900	5-((3-((1S,5S,6S)-3-amino-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)pyrazine-2-carbonitrile::US10889581, Example 103	Beta-secretase 2			 1590							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477900&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125652	442137514							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993561	Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@@]2(CF)C[C@@H]12)C#N	InChI=1S/C22H17F3N4S/c1-13-6-15(9-26)10-28-18(13)5-3-14-2-4-17(25)16(7-14)22(12-24)19-8-21(19,11-23)30-20(27)29-22/h2,4,6-7,10,19H,8,11-12H2,1H3,(H2,27,29)/t19-,21-,22-/m1/s1	RGTGFOOOUNAWIC-CEMLEFRQSA-N	477901	6-((3-((1S,5S,6S)-3-amino-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)-5-methylnicotinonitrile::US10889581, Example 104	Beta-secretase 2			 2280							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477901&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126337	442137515							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993564	CC#CCOc1ccc(nc1)C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@@]2(CF)C[C@@H]12	InChI=1S/C24H20F3N3OS/c1-2-3-10-31-18-8-7-17(29-13-18)6-4-16-5-9-20(27)19(11-16)24(15-26)21-12-23(21,14-25)32-22(28)30-24/h5,7-9,11,13,21H,10,12,14-15H2,1H3,(H2,28,30)/t21-,23-,24-/m1/s1	FWQMUIPDWBVIAK-GMKZXUHWSA-N	477902	(1S,5S,6S)-5-(5-((5-(but-2-yn-1-yloxy)pyridin-2-yl)ethynyl)-2-fluorophenyl)-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 105	Beta-secretase 2			 10300							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477902&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			150236639	442137516							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993567	NC1=N[C@@](CF)([C@@H]2C[C@]2(CC#N)S1)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C22H15F2N5S/c23-13-22(19-10-21(19,7-8-25)30-20(27)29-22)17-9-14(3-6-18(17)24)1-4-16-5-2-15(11-26)12-28-16/h2-3,5-6,9,12,19H,7,10,13H2,(H2,27,29)/t19-,21+,22-/m1/s1	RJOFQCKQEMAZEM-BAGYTPMASA-N	477903	6-((3-((1R,5S,6S)-3-amino-1-(cyanomethyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 106	Beta-secretase 2			 4730							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477903&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328504	442137517							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993570	NC1=N[C@@](CF)([C@@H]2C[C@@]2(S1)\C=C\C#N)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C23H15F2N5S/c24-14-23(20-11-22(20,8-1-9-26)31-21(28)30-23)18-10-15(4-7-19(18)25)2-5-17-6-3-16(12-27)13-29-17/h1,3-4,6-8,10,13,20H,11,14H2,(H2,28,30)/b8-1+/t20-,22+,23-/m1/s1	KKRBCUDPEWDQPI-TUUZJDJFSA-N	477904	6-((3-((1R,5S,6S)-3-amino-1-((E)-2-cyanovinyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 107	Beta-secretase 2			 2550							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477904&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141700	442137518							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993573	NC1=N[C@@](CF)([C@@H]2C[C@]2(CF)S1)c1cc(ccc1F)C#Cc1ccc(OCc2ncco2)cn1	InChI=1S/C24H19F3N4O2S/c25-13-23-10-20(23)24(14-26,31-22(28)34-23)18-9-15(2-6-19(18)27)1-3-16-4-5-17(11-30-16)33-12-21-29-7-8-32-21/h2,4-9,11,20H,10,12-14H2,(H2,28,31)/t20-,23-,24-/m1/s1	OMEMOIMHKXXIAX-AGILITTLSA-N	477905	(1S,5S,6S)-5-(2-fluoro-5-((5-(oxazol-2-ylmethoxy)pyridin-2-yl)ethynyl)phenyl)-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 108	Beta-secretase 2			 14100							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477905&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			151349538	442137519							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993576	NC1=N[C@@](CF)([C@@H]2C[C@]2(CF)S1)c1cc(ccc1F)C#Cc1ncc(s1)C#N	InChI=1S/C19H13F3N4S2/c20-9-18-6-15(18)19(10-21,26-17(24)28-18)13-5-11(1-3-14(13)22)2-4-16-25-8-12(7-23)27-16/h1,3,5,8,15H,6,9-10H2,(H2,24,26)/t15-,18-,19-/m1/s1	LTTMNBDRNFKKOY-ATZDWAIDSA-N	477906	2-((3-((1S,5S,6S)-3-amino-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)thiazole-5-carbonitrile::US10889581, Example 109	Beta-secretase 2			 92.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477906&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125810	442137520							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993579	C[C@@]1(N=C(N)S[C@]2(CO)[C@H]1C2(F)F)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C21H15F3N4OS/c1-19(17-20(11-29,21(17,23)24)30-18(26)28-19)15-8-12(4-7-16(15)22)2-5-14-6-3-13(9-25)10-27-14/h3-4,6-8,10,17,29H,11H2,1H3,(H2,26,28)/t17-,19+,20+/m0/s1	DYNPYLMDNBPLJS-DFQSSKMNSA-N	477907	6-((3-((1S,5S,6R)-3-amino-7,7-difluoro-1-(hydroxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 110	Beta-secretase 2			 2080							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477907&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141839	442137521							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993582	NC1=N[C@@](CF)([C@@H]2C[C@@]2(S1)\C=C\C(=O)N1CCOCC1)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C27H23F2N5O2S/c28-17-27(21-13-18(3-6-22(21)29)1-4-20-5-2-19(15-30)16-32-20)23-14-26(23,37-25(31)33-27)8-7-24(35)34-9-11-36-12-10-34/h2-3,5-8,13,16,23H,9-12,14,17H2,(H2,31,33)/b8-7+/t23-,26+,27-/m1/s1	FRVCLHJFWPHQDO-ACYVMRIUSA-N	477908	6-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-3-morpholino-3-oxoprop-1-en-1-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 111	Beta-secretase 2			 405							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477908&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126141	442137522							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993585	CN(C)C(=O)\C=C\[C@]12C[C@H]1[C@](CF)(N=C(N)S2)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C25H21F2N5OS/c1-32(2)22(33)9-10-24-12-21(24)25(15-26,31-23(29)34-24)19-11-16(5-8-20(19)27)3-6-18-7-4-17(13-28)14-30-18/h4-5,7-11,14,21H,12,15H2,1-2H3,(H2,29,31)/b10-9+/t21-,24+,25-/m1/s1	AOKKWUDSGZAXHM-HSWNYDEUSA-N	477909	(E)-3-((1R,5S,6S)-3-amino-5-(5-((5-cyanopyridin-2-yl)ethynyl)-2-fluorophenyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)-N,N-dimethylacrylamide::US10889581, Example 112	Beta-secretase 2			 1590							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477909&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328502	442137523							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993588	NC(=O)C[C@]12C[C@H]1[C@](CF)(N=C(N)S2)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C22H17F2N5OS/c23-12-22(18-8-21(18,9-19(26)30)31-20(27)29-22)16-7-13(3-6-17(16)24)1-4-15-5-2-14(10-25)11-28-15/h2-3,5-7,11,18H,8-9,12H2,(H2,26,30)(H2,27,29)/t18-,21-,22-/m1/s1	RMKIYSYQYMTKCY-STZQEDGTSA-N	477910	2-((1R,5S,6S)-3-amino-5-(5-((5-cyanopyridin-2-yl)ethynyl)-2-fluorophenyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)acetamide::US10889581, Example 113	Beta-secretase 2			 3760							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477910&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125494	442137524							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993591	C[C@@]1(N=C(N)S[C@@]2(CF)C[C@@H]12)c1cc(cnc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C20H15F2N5S/c1-19(16-7-20(16,11-21)28-18(24)27-19)15-6-12(9-26-17(15)22)2-4-14-5-3-13(8-23)10-25-14/h3,5-6,9-10,16H,7,11H2,1H3,(H2,24,27)/t16-,19+,20+/m0/s1	MYTZXYYCRAMPEU-PWIZWCRZSA-N	477911	6-((5-((1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)ethynyl)nicotinonitrile::US10889581, Example 114	Beta-secretase 2			 3370							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477911&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328492	442137525							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993594	Cc1cn(C[C@]23C[C@H]2[C@](CF)(N=C(N)S3)c2cc(ccc2F)C#Cc2ccc(cn2)C#N)nn1	InChI=1S/C24H19F2N7S/c1-15-12-33(32-31-15)14-23-9-21(23)24(13-25,30-22(28)34-23)19-8-16(4-7-20(19)26)2-5-18-6-3-17(10-27)11-29-18/h3-4,6-8,11-12,21H,9,13-14H2,1H3,(H2,28,30)/t21-,23-,24-/m1/s1	BCIAXCKWZIUDAP-GMKZXUHWSA-N	477912	6-((3-((1S,5S,6S)-3-amino-5-(fluoromethyl)-1-((4-methyl-1H-1,2,3-triazol-1-yl)methyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 115	Beta-secretase 2			 2180							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477912&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141445	442137526							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993597	Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@]2(C[C@@H]12)\C=C\C(=O)N1CCOCC1)C#N	InChI=1S/C28H25F2N5O2S/c1-18-12-20(15-31)16-33-23(18)5-3-19-2-4-22(30)21(13-19)28(17-29)24-14-27(24,38-26(32)34-28)7-6-25(36)35-8-10-37-11-9-35/h2,4,6-7,12-13,16,24H,8-11,14,17H2,1H3,(H2,32,34)/b7-6+/t24-,27+,28-/m1/s1	KJOFKJHARIZLRZ-ALCSNEQFSA-N	477913	6-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-3-morpholino-3-oxoprop-1-en-1-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)-5-methylnicotinonitrile::US10889581, Example 116	Beta-secretase 2			 166							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477913&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125648	442137527							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993600	NC1=N[C@@](CF)([C@@H]2C[C@@]2(S1)\C=C\C(=O)N1CCOCC1)c1cc(ccc1F)C#Cc1ncc(Cl)cn1	InChI=1S/C25H22ClF2N5O2S/c26-17-13-30-21(31-14-17)4-2-16-1-3-19(28)18(11-16)25(15-27)20-12-24(20,36-23(29)32-25)6-5-22(34)33-7-9-35-10-8-33/h1,3,5-6,11,13-14,20H,7-10,12,15H2,(H2,29,32)/b6-5+/t20-,24+,25-/m1/s1	UUCVLVXHCQKZPD-ZEBAXETDSA-N	477914	(E)-3-((1R,5S,6S)-3-amino-5-(5-((5-chloropyrimidin-2-yl)ethynyl)-2-fluorophenyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)-1-morpholinoprop-2-en-1-one::US10889581, Example 117	Beta-secretase 2			 12.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477914&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328490	442137528							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993603	Cc1cc(sn1)C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@]2(C[C@@H]12)\C=C\C(=O)N1CCOCC1	InChI=1S/C25H24F2N4O2S2/c1-16-12-18(35-30-16)4-2-17-3-5-20(27)19(13-17)25(15-26)21-14-24(21,34-23(28)29-25)7-6-22(32)31-8-10-33-11-9-31/h3,5-7,12-13,21H,8-11,14-15H2,1H3,(H2,28,29)/b7-6+/t21-,24+,25-/m1/s1	JRYHADPZJXSPRP-BHGTYKIOSA-N	477915	(E)-3-((1R,5S,6S)-3-amino-5-(2-fluoro-5-((3-methylisothiazol-5-yl)ethynyl)phenyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)-1-morpholinoprop-2-en-1-one::US10889581, Example 118	Beta-secretase 2			 17.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477915&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			150731554	442137529							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993606	NC1=N[C@@](CF)([C@@H]2C[C@]2(CCC(=O)N2CCOCC2)S1)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C27H25F2N5O2S/c28-17-27(21-13-18(3-6-22(21)29)1-4-20-5-2-19(15-30)16-32-20)23-14-26(23,37-25(31)33-27)8-7-24(35)34-9-11-36-12-10-34/h2-3,5-6,13,16,23H,7-12,14,17H2,(H2,31,33)/t23-,26+,27-/m1/s1	GQUCJZKBSKTSBA-DURWQBQJSA-N	477916	6-((3-((1S,5S,6S)-3-amino-5-(fluoromethyl)-1-(3-morpholino-3-oxopropyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 119	Beta-secretase 2			 126							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477916&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125573	442137530							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993609	Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@@]2(CCC(=O)N3CCOCC3)C[C@@H]12)C#N	InChI=1S/C28H27F2N5O2S/c1-18-12-20(15-31)16-33-23(18)5-3-19-2-4-22(30)21(13-19)28(17-29)24-14-27(24,38-26(32)34-28)7-6-25(36)35-8-10-37-11-9-35/h2,4,12-13,16,24H,6-11,14,17H2,1H3,(H2,32,34)/t24-,27+,28-/m1/s1	GFZSQUSNLSAKTD-FQLPYIGMSA-N	477917	6-((3-((1S,5S,6S)-3-amino-5-(fluoromethyl)-1-(3-morpholino-3-oxopropyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)-5-methylnicotinonitrile::US10889581, Example 120	Beta-secretase 2			 179							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477917&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125849	442137531							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993612	NC1=N[C@@](CF)([C@@H]2C[C@@]2(S1)\C=C\C(=O)N1CCOCC1)c1cc(ccc1F)C#Cc1ncc(cn1)C#N	InChI=1S/C26H22F2N6O2S/c27-16-26(19-11-17(1-3-20(19)28)2-4-22-31-14-18(13-29)15-32-22)21-12-25(21,37-24(30)33-26)6-5-23(35)34-7-9-36-10-8-34/h1,3,5-6,11,14-15,21H,7-10,12,16H2,(H2,30,33)/b6-5+/t21-,25+,26-/m1/s1	AFTWTRHAYWBSST-ONGRUHMKSA-N	477918	2-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-3-morpholino-3-oxoprop-1-en-1-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)pyrimidine-5-carbonitrile::US10889581, Example 121	Beta-secretase 2			 47.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477918&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126090	442137532							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993615	NC1=N[C@@](CF)([C@@H]2C[C@@]2(S1)\C=C\C(=O)N1CCOCC1)c1cc(ccc1F)C#Cc1ccc(cc1)C#N	InChI=1S/C28H24F2N4O2S/c29-18-28(22-15-20(7-8-23(22)30)4-1-19-2-5-21(17-31)6-3-19)24-16-27(24,37-26(32)33-28)10-9-25(35)34-11-13-36-14-12-34/h2-3,5-10,15,24H,11-14,16,18H2,(H2,32,33)/b10-9+/t24-,27+,28-/m1/s1	HKMWURYHQXDLAG-NVAWJBEOSA-N	477919	4-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-3-morpholino-3-oxoprop-1-en-1-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)benzonitrile::US10889581, Example 122	Beta-secretase 2			 281							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477919&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125377	442137533							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993618	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ncc(cc1C)C#N	InChI=1S/C24H22FN5OS/c1-14-9-16(12-26)13-28-19(14)8-6-15-5-7-18(25)17(10-15)23(2)20-11-24(20,21(31)30(3)4)32-22(27)29-23/h5,7,9-10,13,20H,11H2,1-4H3,(H2,27,29)/t20-,23+,24-/m0/s1	KEYGOCWGASLCFN-ZTCOLXNVSA-N	477920	(1S,5S,6S)-3-amino-5-(5-((5-cyano-3-methyl-2-pyridinyl)ethynyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10889581, Example 123	Beta-secretase 2			 99.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477920&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141881	442137534							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993621	NC1=N[C@@](CF)([C@@H]2C[C@@]2(S1)\C=C\C(=O)N1CCOCC1)c1cc(ccc1F)C#Cc1ncc(cc1F)C#N	InChI=1S/C27H22F3N5O2S/c28-16-27(19-11-17(1-3-20(19)29)2-4-22-21(30)12-18(14-31)15-33-22)23-13-26(23,38-25(32)34-27)6-5-24(36)35-7-9-37-10-8-35/h1,3,5-6,11-12,15,23H,7-10,13,16H2,(H2,32,34)/b6-5+/t23-,26+,27-/m1/s1	NGFGTPHIPOZBPD-HZQXDJCGSA-N	477921	6-((3-((1R,5S,6S)-3-amino-5-(fluoromethyl)-1-((E)-3-morpholino-3-oxoprop-1-en-1-yl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)-5-fluoronicotinonitrile::US10889581, Example 124	Beta-secretase 2			 37.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477921&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125679	442137535							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993624	NC1=N[C@@](CF)([C@@H]2C[C@]2(Cn2ccnc2)S1)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C24H18F2N6S/c25-13-24(21-10-23(21,33-22(28)31-24)14-32-8-7-29-15-32)19-9-16(3-6-20(19)26)1-4-18-5-2-17(11-27)12-30-18/h2-3,5-9,12,15,21H,10,13-14H2,(H2,28,31)/t21-,23-,24-/m1/s1	LVSIXOOZCSCCOL-GMKZXUHWSA-N	477922	6-((3-((1S,5S,6S)-1-((1H-imidazol-1-yl)methyl)-3-amino-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 125	Beta-secretase 2			 8083							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477922&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141692	442137536							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993627	Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C#N)C#N	InChI=1S/C22H16FN5S/c1-13-7-15(10-24)11-27-18(13)6-4-14-3-5-17(23)16(8-14)21(2)19-9-22(19,12-25)29-20(26)28-21/h3,5,7-8,11,19H,9H2,1-2H3,(H2,26,28)/t19-,21+,22+/m0/s1	CBYOFAWUWAYPKP-KSEOMHKRSA-N	477923	(1S,5S,6S)-3-amino-5-(5-((5-cyano-3-methylpyridin-2-yl)ethynyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carbonitrile::US10889581, Example 126	Beta-secretase 2			 617							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477923&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328483	442137537							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993630	CN(C)C(=O)[C@]12C[C@H]1[C@](CF)(N=C(N)S2)c1cc(ccc1F)C#Cc1ncc(cc1C)C#N	InChI=1S/C24H21F2N5OS/c1-14-8-16(11-27)12-29-19(14)7-5-15-4-6-18(26)17(9-15)23(13-25)20-10-24(20,21(32)31(2)3)33-22(28)30-23/h4,6,8-9,12,20H,10,13H2,1-3H3,(H2,28,30)/t20-,23+,24-/m0/s1	ASCVRCHPGUMCIB-ZTCOLXNVSA-N	477924	(1S,5S,6S)-3-amino-5-(5-((5-cyano-3-methylpyridin-2-yl)ethynyl)-2-fluorophenyl)-5-(fluoromethyl)-N,N-dimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10889581, Example 127	Beta-secretase 2			 77.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477924&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141879	442137538							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993633	Cc1cc(cnc1C#Cc1ccc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCCC1)C#N	InChI=1S/C26H24FN5OS/c1-16-11-18(14-28)15-30-21(16)8-6-17-5-7-20(27)19(12-17)25(2)22-13-26(22,34-24(29)31-25)23(33)32-9-3-4-10-32/h5,7,11-12,15,22H,3-4,9-10,13H2,1-2H3,(H2,29,31)/t22-,25+,26-/m0/s1	KGMQOELEPMRZJR-DFCKQENNSA-N	477925	6-((3-((1S,5S,6S)-3-amino-5-methyl-1-(pyrrolidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)-5-methylnicotinonitrile::US10889581, Example 128	Beta-secretase 2			 423							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477925&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125150	442137539							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993636	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ccc(cc1)C#N	InChI=1S/C24H21FN4OS/c1-23(20-13-24(20,21(30)29(2)3)31-22(27)28-23)18-12-16(10-11-19(18)25)7-4-15-5-8-17(14-26)9-6-15/h5-6,8-12,20H,13H2,1-3H3,(H2,27,28)/t20-,23+,24-/m0/s1	NMGJMZGFSOPENJ-ZTCOLXNVSA-N	477926	(1S,5S,6S)-3-amino-5-(5-((4-cyanophenyl)ethynyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10889581, Example 129	Beta-secretase 2			 251							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477926&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141704	442137540							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993639	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ccc(OCC#C)cn1	InChI=1S/C25H23FN4O2S/c1-5-12-32-18-10-9-17(28-15-18)8-6-16-7-11-20(26)19(13-16)24(2)21-14-25(21,22(31)30(3)4)33-23(27)29-24/h1,7,9-11,13,15,21H,12,14H2,2-4H3,(H2,27,29)/t21-,24+,25-/m0/s1	MOAJIFLFRHPNCU-GPUOULLFSA-N	477927	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((5-(2-propyn-1-yloxy)-2-pyridinyl)ethynyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10889581, Example 130	Beta-secretase 2			 432							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477927&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125744	442137541							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993642	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ncc(OCc2ncco2)cc1C	InChI=1S/C27H26FN5O3S/c1-16-11-18(36-15-23-30-9-10-35-23)14-31-21(16)8-6-17-5-7-20(28)19(12-17)26(2)22-13-27(22,24(34)33(3)4)37-25(29)32-26/h5,7,9-12,14,22H,13,15H2,1-4H3,(H2,29,32)/t22-,26+,27-/m0/s1	RAHDYDYNSIAFMG-FDJWOJMMSA-N	477928	(1S,5S,6S)-3-amino-5-(2-fluoro-5-((3-methyl-5-(oxazol-2-ylmethoxy)pyridin-2-yl)ethynyl)phenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10889581, Example 131	Beta-secretase 2			 2175							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477928&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328474	442137542							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993645	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#CC1CC1	InChI=1S/C20H22FN3OS/c1-19(14-10-13(8-9-15(14)21)7-6-12-4-5-12)16-11-20(16,17(25)24(2)3)26-18(22)23-19/h8-10,12,16H,4-5,11H2,1-3H3,(H2,22,23)/t16-,19+,20-/m0/s1	ZETLMDXVTJYGIP-DBVUQKKJSA-N	477929	(1S,5S,6S)-3-amino-5-(5-(cyclopropylethynyl)-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10889581, Example 132	Beta-secretase 2			 7.00							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477929&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135142122	442137543							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993648	COC[C@]12CC1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ccc(cn1)C#N	InChI=1S/C22H19FN4OS/c1-21(19-10-22(19,13-28-2)29-20(25)27-21)17-9-14(5-8-18(17)23)3-6-16-7-4-15(11-24)12-26-16/h4-5,7-9,12,19H,10,13H2,1-2H3,(H2,25,27)/t19?,21-,22-/m1/s1	QFJKGLXJJDXVNA-CEAUUGKZSA-N	477930	6-((3-((1S,5S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)nicotinonitrile::US10889581, Example 133	Beta-secretase 2			 2325							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477930&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135142120	442137544							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993651	COC[C@]12CC1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ncc(Cl)cc1C	InChI=1S/C22H21ClFN3OS/c1-13-8-15(23)11-26-18(13)7-5-14-4-6-17(24)16(9-14)21(2)19-10-22(19,12-28-3)29-20(25)27-21/h4,6,8-9,11,19H,10,12H2,1-3H3,(H2,25,27)/t19?,21-,22-/m1/s1	WRIHTLGFUKBBKQ-CEAUUGKZSA-N	477931	(1S,5S)-5-(5-((5-chloro-3-methylpyridin-2-yl)ethynyl)-2-fluorophenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 134	Beta-secretase 2			 613							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477931&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125784	442137545							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993654	COC[C@]12CC1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ncc(cc1C)C#N	InChI=1S/C23H21FN4OS/c1-14-8-16(11-25)12-27-19(14)7-5-15-4-6-18(24)17(9-15)22(2)20-10-23(20,13-29-3)30-21(26)28-22/h4,6,8-9,12,20H,10,13H2,1-3H3,(H2,26,28)/t20?,22-,23-/m1/s1	OBBHGUFQORPJJT-JHRSTNGLSA-N	477932	6-((3-((1S,5S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)ethynyl)-5-methylnicotinonitrile::US10889581, Example 135	Beta-secretase 2			 1465							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477932&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328496	442137546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993657	Cc1cc(cnc1C#Cc1cnc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(CC12)C(=O)N1CCOCC1)C#N	InChI=1S/C25H23FN6O2S/c1-15-9-17(12-27)14-29-19(15)4-3-16-10-18(21(26)30-13-16)24(2)20-11-25(20,35-23(28)31-24)22(33)32-5-7-34-8-6-32/h9-10,13-14,20H,5-8,11H2,1-2H3,(H2,28,31)/t20?,24-,25+/m1/s1	QPLBYIGLUXTAPU-RQFYCUQDSA-N	477933	6-((5-((1S,5S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)ethynyl)-5-methylnicotinonitrile::US10889581, Example 136	Beta-secretase 2			 974							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477933&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			153328484	442137547							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993660	Cc1cc(cnc1C#Cc1cnc(F)c(c1)[C@@]1(C)N=C(N)S[C@]2(CC12)C(=O)N1CCCC1)C#N	InChI=1S/C25H23FN6OS/c1-15-9-17(12-27)14-29-19(15)6-5-16-10-18(21(26)30-13-16)24(2)20-11-25(20,34-23(28)31-24)22(33)32-7-3-4-8-32/h9-10,13-14,20H,3-4,7-8,11H2,1-2H3,(H2,28,31)/t20?,24-,25+/m1/s1	KTNWHHMLWOVZTA-RQFYCUQDSA-N	477934	6-((5-((1S,5S)-3-amino-5-methyl-1-(pyrrolidine-1-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)ethynyl)-5-methylnicotinonitrile::US10889581, Example 137	Beta-secretase 2			 474							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477934&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125441	442137548							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993663	NC1=N[C@@](CF)([C@@H]2C[C@]2(CF)S1)c1cc(ccc1F)C#Cc1cc(Cl)ccn1	InChI=1S/C20H15ClF3N3S/c21-13-5-6-26-14(8-13)3-1-12-2-4-16(24)15(7-12)20(11-23)17-9-19(17,10-22)28-18(25)27-20/h2,4-8,17H,9-11H2,(H2,25,27)/t17-,19-,20-/m1/s1	MLJGESCVVGWMSL-MISYRCLQSA-N	477935	(1S,5S,6S)-5-(5-((4-chloropyridin-2-yl)ethynyl)-2-fluorophenyl)-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 138	Beta-secretase 2			 77.0							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477935&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			151087231	442137549							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
993666	CN(C)C(=O)[C@]12C[C@H]1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#C	InChI=1S/C17H18FN3OS/c1-5-10-6-7-12(18)11(8-10)16(2)13-9-17(13,14(22)21(3)4)23-15(19)20-16/h1,6-8,13H,9H2,2-4H3,(H2,19,20)/t13-,16+,17-/m0/s1	CFWGZKJFJHRPLR-XKQJLSEDSA-N	477936	(1S,5S,6S)-3-amino-5-(5-ethynyl-2-fluorophenyl)-N,N,5-trimethyl-2-thia-4-azabicyclo[4.1.0]hept-3-ene-1-carboxamide::US10889581, Example 123d	Beta-secretase 2			 142							US Patent		10.7270/Q20868DB		aid1805175	US10889581	Allen, JR; Amegadzie, A; Bourbeau, MP; Chen, JJ; Frohn, MJ; Harrington, PE; Low, JD; Ma, VV; Nguyen, TT; Pickrell, A; Reeves, C	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=477936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=477936&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135141685	442137550							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
988448	CC#Cc1ccc2[nH]c(c(Cl)c2c1)[C@]1(C)CC(=O)N(C)C(=N)N1			476661	(S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)-2-imino-3,6-dimethyl- tetrahydropyrimidin-4(1H)-one::US10870635, Example 38	Beta-secretase 2			 24.0							US Patent		10.7270/Q2474DXV		aid1805132	US10870635	Cherukury, M; Lin, H; Yu, SC; Phang, R; Rajan, YC; Tang-Liu, DD; White, AD; Malone, T; Beresis, R	ALLGENESIS BIOTHERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=476661	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=476661&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122647936	442076707							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
988466	CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C22H22N2O2S2/c1-5-6-14-7-9-18-16(11-14)17-12-15(8-10-19(17)27-18)22(4)13-28(25,26)21(2,3)20(23)24-22/h7-12H,13H2,1-4H3,(H2,23,24)/t22-/m0/s1	TYFDPTNOAQWDOO-QFIPXVFZSA-N	476688	(R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)dibenzo[b,d]thiophen- 2-yl)thiomorpholine 1,1-dioxide::US10870635, Example 103	Beta-secretase 2			 12.0							US Patent		10.7270/Q2474DXV		aid1805132	US10870635	Cherukury, M; Lin, H; Yu, SC; Phang, R; Rajan, YC; Tang-Liu, DD; White, AD; Malone, T; Beresis, R	ALLGENESIS BIOTHERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=476688	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=476688&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122641645	442076734							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
988471	CC#Cc1ccc2sc3cc(F)c(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1	InChI=1S/C22H21FN2O2S2/c1-5-6-13-7-8-18-14(9-13)15-10-16(17(23)11-19(15)28-18)22(4)12-29(26,27)21(2,3)20(24)25-22/h7-11H,12H2,1-4H3,(H2,24,25)/t22-/m0/s1	KGKREPAGYWRXPP-QFIPXVFZSA-N	476692	(R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thiophen-2-yl)-3-imino- 2,2,5-trimethylthiomorpholine 1,1-dioxide::US10870635, Example 109	Beta-secretase 2			 16.0							US Patent		10.7270/Q2474DXV		aid1805132	US10870635	Cherukury, M; Lin, H; Yu, SC; Phang, R; Rajan, YC; Tang-Liu, DD; White, AD; Malone, T; Beresis, R	ALLGENESIS BIOTHERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=476692	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=476692&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			122641656	442076738							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51347651	C[C@]1(CCC(F)(F)C(N)=N1)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C18H17F4N5O2/c1-17(4-5-18(21,22)16(23)27-17)11-6-10(2-3-12(11)20)26-15(28)13-7-25-14(8-24-13)29-9-19/h2-3,6-8H,4-5,9H2,1H3,(H2,23,27)(H,26,28)/t17-/m0/s1	HMMWZIDNPYYZHM-KRWDZBQOSA-N	50545174	CHEMBL4637181	Beta-secretase 2			 126							ChEMBL	10.1016/j.bmcl.2020.126999	10.7270/Q2W95DRH	32089426			Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50545174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50545174&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156011346	442110985							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51347656	NC1=N[C@@](CF)(CCC1(F)F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C18H16F5N5O2/c19-8-17(3-4-18(22,23)16(24)28-17)11-5-10(1-2-12(11)21)27-15(29)13-6-26-14(7-25-13)30-9-20/h1-2,5-7H,3-4,8-9H2,(H2,24,28)(H,27,29)/t17-/m1/s1	JAHKMCQBZQTJIC-QGZVFWFLSA-N	50545175	CHEMBL4643511	Beta-secretase 2			 138							ChEMBL	10.1016/j.bmcl.2020.126999	10.7270/Q2W95DRH	32089426			Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50545175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50545175&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156017905	442110986							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51347666	NC1=N[C@]2(COCC[C@H]2CC1(F)F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C20H19F4N5O3/c21-10-32-16-8-26-15(7-27-16)17(30)28-12-1-2-14(22)13(5-12)19-9-31-4-3-11(19)6-20(23,24)18(25)29-19/h1-2,5,7-8,11H,3-4,6,9-10H2,(H2,25,29)(H,28,30)/t11-,19-/m0/s1	HPFYCMCPLABMMZ-WLRWDXFRSA-N	50545176	CHEMBL4637358	Beta-secretase 2			 10							ChEMBL	10.1016/j.bmcl.2020.126999	10.7270/Q2W95DRH	32089426			Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50545176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50545176&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156011363	442110987							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
51347671	NC1=N[C@]2(CCOC[C@H]2CC1(F)F)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F	InChI=1S/C20H19F4N5O3/c21-10-32-16-8-26-15(7-27-16)17(30)28-12-1-2-14(22)13(5-12)19-3-4-31-9-11(19)6-20(23,24)18(25)29-19/h1-2,5,7-8,11H,3-4,6,9-10H2,(H2,25,29)(H,28,30)/t11-,19+/m1/s1	CLJYRTSUHFRECZ-WYRIXSBYSA-N	50545177	CHEMBL4635770	Beta-secretase 2			 1072							ChEMBL	10.1016/j.bmcl.2020.126999	10.7270/Q2W95DRH	32089426			Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ	Janssen Research & Development	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50545177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50545177&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			156014061	442110988							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044108	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc3CCCOc3cn2)ccc1F	InChI=1S/C21H22F2N4O3S/c1-21(12-31(28,29)27(2)20(24)26-21)15-8-13(5-6-16(15)22)9-17(23)18-10-14-4-3-7-30-19(14)11-25-18/h5-6,8-11H,3-4,7,12H2,1-2H3,(H2,24,26)/b17-9-/t21-/m0/s1	RWGILFQBVCWEPP-YWUCYRDRSA-N	501320	US11021493, Example 239	Beta-secretase 2			 143							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501320&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125928	459086660							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044112	CN1C(=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(F)cn2)ccc1F)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C	InChI=1S/C28H33F3N4O6S/c1-26(2,3)40-24(36)35(25(37)41-27(4,5)6)23-33-28(7,16-42(38,39)34(23)8)19-13-17(9-11-20(19)30)14-21(31)22-12-10-18(29)15-32-22/h9-15H,16H2,1-8H3/b21-14-/t28-/m0/s1	PYFGTSPGBKDYSE-JGIZHUKKSA-N	501321	US11021493, Example 240	Beta-secretase 2			 8.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501321	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501321&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			154601227	459086661							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044116	COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C18H19F2N5O3S/c1-18(10-29(26,27)25(2)17(21)24-18)12-6-11(4-5-13(12)19)7-14(20)15-8-23-16(28-3)9-22-15/h4-9H,10H2,1-3H3,(H2,21,24)/b14-7-/t18-/m0/s1	QHUCNZSOEORCHE-WMBZCPDOSA-N	501322	US11021493, Example 241	Beta-secretase 2			 75.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501322&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126128	459086662							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044120	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C19H16ClF5N4O2S/c1-18(9-32(30,31)29(2)17(26)28-18)12-5-10(3-4-14(12)21)6-15(22)16-13(20)7-11(8-27-16)19(23,24)25/h3-8H,9H2,1-2H3,(H2,26,28)/b15-6-/t18-/m0/s1	FETNHRVYDCSXRL-HMMSMWIJSA-N	501323	US11021493, Example 242	Beta-secretase 2			 10.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501323	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501323&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126398	459086663							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044124	CCOC(=O)COc1cnc(cn1)C(\F)=C\c1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C21H22F3N5O5S/c1-4-33-18(30)10-34-17-9-26-16(8-27-17)14(22)6-12-5-13(19(24)15(23)7-12)21(2)11-35(31,32)29(3)20(25)28-21/h5-9H,4,10-11H2,1-3H3,(H2,25,28)/b14-6-/t21-/m0/s1	BGOOUINKRUJXDU-XLPSYMGOSA-N	501324	US11021493, Example 243	Beta-secretase 2			 398							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501324&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			142379324	459086664							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044128	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C19H17F5N4O2S/c1-18(10-31(29,30)28(2)17(25)27-18)13-7-11(3-5-14(13)20)8-15(21)16-6-4-12(9-26-16)19(22,23)24/h3-9H,10H2,1-2H3,(H2,25,27)/b15-8-/t18-/m0/s1	QLUBOEZPYLJTTP-ODZYNRFZSA-N	501325	US11021493, Example 244	Beta-secretase 2			 31.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501325	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501325&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125885	459086665							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044132	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(cc2C)C#N)ccc1F	InChI=1S/C20H19F2N5O2S/c1-12-6-14(9-23)10-25-18(12)17(22)8-13-4-5-16(21)15(7-13)20(2)11-30(28,29)27(3)19(24)26-20/h4-8,10H,11H2,1-3H3,(H2,24,26)/b17-8-/t20-/m0/s1	JGFHZPDIRDNOAS-MBNKTHEGSA-N	501326	US11021493, Example 245	Beta-secretase 2			 21.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501326&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125745	459086666							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044136	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3ncc(C)o3)cn2)cc(F)c1F	InChI=1S/C22H21F3N6O4S/c1-12-7-28-19(35-12)10-34-18-9-27-17(8-29-18)15(23)5-13-4-14(20(25)16(24)6-13)22(2)11-36(32,33)31(3)21(26)30-22/h4-9H,10-11H2,1-3H3,(H2,26,30)/b15-5-/t22-/m0/s1	IMDFYPDEKRNNRW-JARJPIKVSA-N	501327	US11021493, Example 246	Beta-secretase 2			 111							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501327&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125763	459086667							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044140	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F	InChI=1S/C18H17BrF2N4O2S/c1-18(10-28(26,27)25(2)17(22)24-18)13-7-11(3-5-14(13)20)8-15(21)16-6-4-12(19)9-23-16/h3-9H,10H2,1-2H3,(H2,22,24)/b15-8-/t18-/m0/s1	UBXLUDVBTXDSQS-ODZYNRFZSA-N	501328	US11021493, Example 247::US11021493, Example 251	Beta-secretase 2			 7.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501328&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126437	459086668							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044144	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(cn2)C#CC2CC2)ccc1F	InChI=1S/C22H21F2N5O2S/c1-22(13-32(30,31)29(2)21(25)28-22)17-9-15(6-8-18(17)23)10-19(24)20-12-26-16(11-27-20)7-5-14-3-4-14/h6,8-12,14H,3-4,13H2,1-2H3,(H2,25,28)/b19-10-/t22-/m0/s1	XWNKXBFCNACQCF-BQHBEAIMSA-N	501329	US11021493, Example 248	Beta-secretase 2			 16.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501329&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125909	459086669							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044148	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nccn3C)cn2)cc(F)c1F	InChI=1S/C22H22F3N7O3S/c1-22(12-36(33,34)32(3)21(26)30-22)14-6-13(8-16(24)20(14)25)7-15(23)17-9-29-19(10-28-17)35-11-18-27-4-5-31(18)2/h4-10H,11-12H2,1-3H3,(H2,26,30)/b15-7-/t22-/m0/s1	JWGDWCRPFMLANW-AELLWPAVSA-N	501330	US11021493, Example 249	Beta-secretase 2			 1815							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501330	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501330&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126277	459086670							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044152	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc3nccnc3cn2)ccc1F	InChI=1S/C20H18F2N6O2S/c1-20(11-31(29,30)28(2)19(23)27-20)13-7-12(3-4-14(13)21)8-15(22)16-9-17-18(10-26-16)25-6-5-24-17/h3-10H,11H2,1-2H3,(H2,23,27)/b15-8-/t20-/m0/s1	TZEUUXFFMGKWJK-SLPYIPCOSA-N	501331	US11021493, Example 250	Beta-secretase 2			 3945							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501331	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501331&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125674	459086671							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044156	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F	InChI=1S/C18H17BrF2N4O2S/c1-18(10-28(26,27)25(2)17(22)24-18)13-7-11(3-5-14(13)20)8-15(21)16-6-4-12(19)9-23-16/h3-9H,10H2,1-2H3,(H2,22,24)/b15-8-/t18-/m0/s1	UBXLUDVBTXDSQS-ODZYNRFZSA-N	501328	US11021493, Example 247::US11021493, Example 251	Beta-secretase 2			 36.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501328&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126437	459086668							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044160	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#CCO)cn2)ccc1F	InChI=1S/C21H21F2N5O4S/c1-21(13-33(30,31)28(2)20(24)27-21)15-9-14(5-6-16(15)22)10-17(23)18-11-26-19(12-25-18)32-8-4-3-7-29/h5-6,9-12,29H,7-8,13H2,1-2H3,(H2,24,27)/b17-10-/t21-/m0/s1	WJBMCSABCOVYDH-OIOSCTRGSA-N	501333	US11021493, Example 252	Beta-secretase 2			 56.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501333&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125370	459086672							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044164	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(s2)C#N)ccc1F	InChI=1S/C17H15F2N5O2S2/c1-17(9-28(25,26)24(2)16(21)23-17)12-5-10(3-4-13(12)18)6-14(19)15-22-8-11(7-20)27-15/h3-6,8H,9H2,1-2H3,(H2,21,23)/b14-6-/t17-/m0/s1	BSFKLQRMSXSNSC-ZRBJYGNNSA-N	501334	US11021493, Example 253	Beta-secretase 2			 21.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501334	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501334&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125915	459086673							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044168	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#CCF)cn2)ccc1F	InChI=1S/C21H20F3N5O3S/c1-21(13-33(30,31)29(2)20(25)28-21)15-9-14(5-6-16(15)23)10-17(24)18-11-27-19(12-26-18)32-8-4-3-7-22/h5-6,9-12H,7-8,13H2,1-2H3,(H2,25,28)/b17-10-/t21-/m0/s1	SIQONXZDOCTZEC-OIOSCTRGSA-N	501335	US11021493, Example 254	Beta-secretase 2			 52.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501335	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501335&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125115	459086674							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044172	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc3OCCOc3n2)ccc1F	InChI=1S/C20H20F2N4O4S/c1-20(11-31(27,28)26(2)19(23)25-20)13-9-12(3-4-14(13)21)10-15(22)16-5-6-17-18(24-16)30-8-7-29-17/h3-6,9-10H,7-8,11H2,1-2H3,(H2,23,25)/b15-10-/t20-/m0/s1	VBTANQYCRRGBKE-ZRGSNEMSSA-N	501336	US11021493, Example 255	Beta-secretase 2			 458							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501336&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125923	459086675							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044176	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(s2)C#N)ccc1F	InChI=1S/C18H16F2N4O2S2/c1-18(10-28(25,26)24(2)17(22)23-18)13-7-11(3-5-14(13)19)8-15(20)16-6-4-12(9-21)27-16/h3-8H,10H2,1-2H3,(H2,22,23)/b15-8-/t18-/m0/s1	XQUABQMBRXDKHE-ODZYNRFZSA-N	501337	US11021493, Example 256	Beta-secretase 2			 14.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501337	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501337&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125718	459086676							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044180	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc3OCOc3cn2)ccc1F	InChI=1S/C19H18F2N4O4S/c1-19(9-30(26,27)25(2)18(22)24-19)12-5-11(3-4-13(12)20)6-14(21)15-7-16-17(8-23-15)29-10-28-16/h3-8H,9-10H2,1-2H3,(H2,22,24)/b14-6-/t19-/m0/s1	DFZLSFLDVAUKRW-COXIKBTRSA-N	501338	US11021493, Example 257	Beta-secretase 2			 235							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501338	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501338&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125119	459086677							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044184	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(OC(F)(F)F)cn2)ccc1F	InChI=1S/C19H17F5N4O3S/c1-18(10-32(29,30)28(2)17(25)27-18)13-7-11(3-5-14(13)20)8-15(21)16-6-4-12(9-26-16)31-19(22,23)24/h3-9H,10H2,1-2H3,(H2,25,27)/b15-8-/t18-/m0/s1	PAYPZUPWSYKEGB-ODZYNRFZSA-N	501339	US11021493, Example 258	Beta-secretase 2			 40.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501339&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125159	459086678							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044188	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc3ccccc3cn2)ccc1F	InChI=1S/C22H20F2N4O2S/c1-22(13-31(29,30)28(2)21(25)27-22)17-9-14(7-8-18(17)23)10-19(24)20-11-15-5-3-4-6-16(15)12-26-20/h3-12H,13H2,1-2H3,(H2,25,27)/b19-10-/t22-/m0/s1	LKFDPAXLHILZGB-BQHBEAIMSA-N	501340	US11021493, Example 259	Beta-secretase 2			 41.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501340&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126134	459086679							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044192	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc3cc(Cl)ccc3cn2)ccc1F	InChI=1S/C22H19ClF2N4O2S/c1-22(12-32(30,31)29(2)21(26)28-22)17-7-13(3-6-18(17)24)8-19(25)20-10-15-9-16(23)5-4-14(15)11-27-20/h3-11H,12H2,1-2H3,(H2,26,28)/b19-8-/t22-/m0/s1	UMMUINSOEBCGON-ALPFBALHSA-N	501341	US11021493, Example 260	Beta-secretase 2			 112							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501341	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501341&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126286	459086680							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044196	CC1(C)C(N)=N[C@]2(CO[C@H]2S1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H18F2N4O3S/c1-20(2)18(25)27-21(11-30-19(21)31(20,28)29)14-7-12(3-5-15(14)22)8-16(23)17-6-4-13(9-24)10-26-17/h3-8,10,19H,11H2,1-2H3,(H2,25,27)/b16-8-/t19-,21+/m0/s1	OGMLLMSNOCGCTB-DYWQXGHASA-N	501342	US11021493, Example 261	Beta-secretase 2			 12.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501342&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			155003862	459086681							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044200	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(F)cn2)ccc1F	InChI=1S/C20H20F3N3O2S/c1-19(2)18(24)26-20(3,11-29(19,27)28)14-8-12(4-6-15(14)22)9-16(23)17-7-5-13(21)10-25-17/h4-10H,11H2,1-3H3,(H2,24,26)/b16-9-/t20-/m0/s1	ZWEYAKHRZVCNHF-CPYXBQISSA-N	501343	US11021493, Example 262	Beta-secretase 2			 11.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501343	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501343&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125844	459086682							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044204	COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C20H22F2N4O3S/c1-19(2)18(23)26-20(3,11-30(19,27)28)13-7-12(5-6-14(13)21)8-15(22)16-9-25-17(29-4)10-24-16/h5-10H,11H2,1-4H3,(H2,23,26)/b15-8-/t20-/m0/s1	ZSGMTRQKPXSNES-SLPYIPCOSA-N	501344	US11021493, Example 263	Beta-secretase 2			 190							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501344	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501344&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126301	459086683							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044208	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C21H19ClF5N3O2S/c1-19(2)18(28)30-20(3,10-33(19,31)32)13-6-11(4-5-15(13)23)7-16(24)17-14(22)8-12(9-29-17)21(25,26)27/h4-9H,10H2,1-3H3,(H2,28,30)/b16-7-/t20-/m0/s1	KPJOVXBLKQILFN-YYFKYVOKSA-N	501345	US11021493, Example 264	Beta-secretase 2			 38.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501345	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501345&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126294	459086684							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044212	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C(F)(F)F)ccc1F	InChI=1S/C21H20F5N3O2S/c1-19(2)18(27)29-20(3,11-32(19,30)31)14-8-12(4-6-15(14)22)9-16(23)17-7-5-13(10-28-17)21(24,25)26/h4-10H,11H2,1-3H3,(H2,27,29)/b16-9-/t20-/m0/s1	HRXNXBJPPPFSBG-CPYXBQISSA-N	501346	US11021493, Example 265	Beta-secretase 2			 43.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501346	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501346&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126087	459086685							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044216	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(cn2)C2CC2)ccc1F	InChI=1S/C20H21F2N5O2S/c1-20(11-30(28,29)27(2)19(23)26-20)14-7-12(3-6-15(14)21)8-16(22)18-10-24-17(9-25-18)13-4-5-13/h3,6-10,13H,4-5,11H2,1-2H3,(H2,23,26)/b16-8-/t20-/m0/s1	FPWCAPVHKPTAKJ-JYKCAJKKSA-N	501347	US11021493, Example 266	Beta-secretase 2			 78.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501347	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501347&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126448	459086686							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044220	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2nc(cs2)C#N)ccc1F	InChI=1S/C17H15F2N5O2S2/c1-17(9-28(25,26)24(2)16(21)23-17)12-5-10(3-4-13(12)18)6-14(19)15-22-11(7-20)8-27-15/h3-6,8H,9H2,1-2H3,(H2,21,23)/b14-6-/t17-/m0/s1	KKSXRZCCKYLUMJ-ZRBJYGNNSA-N	501348	US11021493, Example 267	Beta-secretase 2			 6.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501348	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501348&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125805	459086687							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044224	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C21H19ClF2N4O2S/c1-20(2)19(26)28-21(3,11-31(20,29)30)14-6-12(4-5-16(14)23)8-17(24)18-15(22)7-13(9-25)10-27-18/h4-8,10H,11H2,1-3H3,(H2,26,28)/b17-8-/t21-/m0/s1	UYPPPQCTBZUSML-NLOKWTDQSA-N	501349	US11021493, Example 268	Beta-secretase 2			 12.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501349	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501349&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125830	459086688							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044228	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H16ClF2N5O2S/c1-19(10-30(28,29)27(2)18(24)26-19)13-5-11(3-4-15(13)21)7-16(22)17-14(20)6-12(8-23)9-25-17/h3-7,9H,10H2,1-2H3,(H2,24,26)/b16-7-/t19-/m0/s1	XWWLSPXAPGRIDQ-CWWGLNLWSA-N	501350	US11021493, Example 269	Beta-secretase 2			 3.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501350	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501350&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125452	459086689							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044232	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(F)cn2)ccc1F	InChI=1S/C18H17F3N4O2S/c1-18(10-28(26,27)25(2)17(22)24-18)13-7-11(3-5-14(13)20)8-15(21)16-6-4-12(19)9-23-16/h3-9H,10H2,1-2H3,(H2,22,24)/b15-8-/t18-/m0/s1	LZFRJYNGHPKGAA-ODZYNRFZSA-N	501351	US11021493, Example 270	Beta-secretase 2			 28.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501351	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501351&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126365	459086690							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044236	COc1cnc(cn1)C(\F)=C\c1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C18H18F3N5O3S/c1-18(9-30(27,28)26(2)17(22)25-18)11-4-10(6-13(20)16(11)21)5-12(19)14-7-24-15(29-3)8-23-14/h4-8H,9H2,1-3H3,(H2,22,25)/b12-5-/t18-/m0/s1	OROKNBFLLSTYNO-KYDJUPTOSA-N	501352	US11021493, Example 271	Beta-secretase 2			 398							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501352	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501352&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126160	459086691							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044240	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(cc2Cl)C(F)(F)F)cc(F)c1F	InChI=1S/C19H15ClF6N4O2S/c1-18(8-33(31,32)30(2)17(27)29-18)11-3-9(4-13(21)15(11)23)5-14(22)16-12(20)6-10(7-28-16)19(24,25)26/h3-7H,8H2,1-2H3,(H2,27,29)/b14-5-/t18-/m0/s1	XTPKUGBRVKAUSC-BLCJYSFRSA-N	501353	US11021493, Example 272	Beta-secretase 2			 22.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501353&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125772	459086692							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044244	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C(F)(F)F)cc(F)c1F	InChI=1S/C19H16F6N4O2S/c1-18(9-32(30,31)29(2)17(26)28-18)12-5-10(7-14(21)16(12)22)6-13(20)15-4-3-11(8-27-15)19(23,24)25/h3-8H,9H2,1-2H3,(H2,26,28)/b13-6-/t18-/m0/s1	SPTRDEUPNNMVMR-BXIWPEDZSA-N	501354	US11021493, Example 273	Beta-secretase 2			 46.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501354	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501354&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125688	459086693							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044248	Cc1cc(cnc1\C(F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#N	InChI=1S/C22H22F2N4O2S/c1-13-7-15(10-25)11-27-19(13)18(24)9-14-5-6-17(23)16(8-14)22(4)12-31(29,30)21(2,3)20(26)28-22/h5-9,11H,12H2,1-4H3,(H2,26,28)/b18-9-/t22-/m0/s1	SCXIEKHWLXYYHR-KRJVNCKSSA-N	501355	US11021493, Example 274	Beta-secretase 2			 28.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501355	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501355&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135124957	459086694							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044252	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)cc(F)c1F	InChI=1S/C19H16F3N5O2S/c1-19(10-30(28,29)27(2)18(24)26-19)13-5-12(7-15(21)17(13)22)6-14(20)16-4-3-11(8-23)9-25-16/h3-7,9H,10H2,1-2H3,(H2,24,26)/b14-6-/t19-/m0/s1	HDKKEPJHRYPLPT-COXIKBTRSA-N	501188	US11021493, Example 107::US11021493, Example 275	Beta-secretase 2			 9.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501188&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126403	459086542							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044256	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc(cc2Cl)C#N)cc(F)c1F	InChI=1S/C19H15ClF3N5O2S/c1-19(9-31(29,30)28(2)18(25)27-19)12-3-10(5-14(21)16(12)23)6-15(22)17-13(20)4-11(7-24)8-26-17/h3-6,8H,9H2,1-2H3,(H2,25,27)/b15-6-/t19-/m0/s1	XSTFBOBOPVTQOH-RQYCBZRCSA-N	501357	US11021493, Example 276	Beta-secretase 2			 6.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501357	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501357&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125921	459086695							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044260	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)C2CCOC2)ccc1F	InChI=1S/C20H23F3N2O3S/c1-19(17-4-6-20(11-21,18(24)25-19)29(17,26)27)14-8-12(2-3-15(14)22)9-16(23)13-5-7-28-10-13/h2-3,8-9,13,17H,4-7,10-11H2,1H3,(H2,24,25)/b16-9-/t13?,17-,19+,20-/m0/s1	SPLFNKQXQBICLZ-NSFVFAORSA-N	501358	(1R,4R,5S)-2-amino-4-(2-fluoro-5-((Z)-2-fluoro-2-(tetrahydrofuran-2-yl)vinyl)phenyl)-1-(fluoromethyl)-4-methyl-8-thia-3-azabicyclo[3.2.1]oct-2-ene 8,8-dioxide; and::US11021493, Example 277	Beta-secretase 2			 139							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501358	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501358&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			154601223	459086696							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044264	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(\F)C2CCCO2)ccc1F	InChI=1S/C20H23F3N2O3S/c1-19(17-6-7-20(11-21,18(24)25-19)29(17,26)27)13-9-12(4-5-14(13)22)10-15(23)16-3-2-8-28-16/h4-5,9-10,16-17H,2-3,6-8,11H2,1H3,(H2,24,25)/b15-10+/t16?,17-,19+,20-/m0/s1	CNCHXAPMGRCDFK-FFIUSHDYSA-N	501359	US11021493, Example 278	Beta-secretase 2			 624							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501359	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501359&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126444	459086697							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044268	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C\c2ccc(Cl)cc2)ccc1F	InChI=1S/C21H22ClFN2O2S/c1-20(2)19(24)25-21(3,13-28(20,26)27)17-12-15(8-11-18(17)23)5-4-14-6-9-16(22)10-7-14/h4-12H,13H2,1-3H3,(H2,24,25)/b5-4+/t21-/m0/s1	PCOXDXAAPSNFFJ-FNEOHHHZSA-N	501360	US11021493, Example 279	Beta-secretase 2			 56.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501360	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501360&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125898	459086698							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043552	C[C@]1(CS(=O)(=O)C2(CCC2)C(N)=N1)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C21H20ClF2N3O2S/c1-20(12-30(28,29)21(7-2-8-21)19(25)27-20)15-9-13(3-5-16(15)23)10-17(24)18-6-4-14(22)11-26-18/h3-6,9-11H,2,7-8,12H2,1H3,(H2,25,27)/b17-10-/t20-/m0/s1	GVTVQMUQHMNEEL-PSXSOWLISA-N	501181	US11021493, Example 100	Beta-secretase 2			 7.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501181&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125624	459086535							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043556	C[C@@]1(N=C(N)[C@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F	InChI=1S/C21H19BrF3N3O2S/c1-20(18-6-7-21(11-23,19(26)28-20)31(18,29)30)14-8-12(2-4-15(14)24)9-16(25)17-5-3-13(22)10-27-17/h2-5,8-10,18H,6-7,11H2,1H3,(H2,26,28)/b16-9-/t18-,20+,21+/m0/s1	YBTHOLAPRYEQLF-QPZHNHRQSA-N	501182	US11021493, Example 101	Beta-secretase 2			 13.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501182&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			162370043	459086536							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043560	C[C@@]1(N=C(N)[C@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H19F3N4O2S/c1-21(19-6-7-22(12-23,20(27)29-21)32(19,30)31)15-8-13(2-4-16(15)24)9-17(25)18-5-3-14(10-26)11-28-18/h2-5,8-9,11,19H,6-7,12H2,1H3,(H2,27,29)/b17-9-/t19-,21+,22+/m0/s1	VJDIDSYICPCAPO-RZWCVLNRSA-N	501183	US11021493, Example 102	Beta-secretase 2			 32.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501183&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			162370044	459086537							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043564	C[C@]1(CS(=O)(=O)C2(CCC2)C(N)=N1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C22H20F2N4O2S/c1-21(13-31(29,30)22(7-2-8-22)20(26)28-21)16-9-14(3-5-17(16)23)10-18(24)19-6-4-15(11-25)12-27-19/h3-6,9-10,12H,2,7-8,13H2,1H3,(H2,26,28)/b18-10-/t21-/m0/s1	YKXJXOBEJFRFKF-YJXRAILPSA-N	501184	US11021493, Example 103	Beta-secretase 2			 50.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501184&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125845	459086538							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043568	CN1C(NC(=O)OC(C)(C)C)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C23H25ClF2N4O4S/c1-22(2,3)34-21(31)28-20-29-23(4,13-35(32,33)30(20)5)16-10-14(6-8-17(16)25)11-18(26)19-9-7-15(24)12-27-19/h6-12H,13H2,1-5H3,(H,28,29,31)/b18-11-/t23-/m0/s1	OBQVSGQQXIVESB-RXATWSHQSA-N	501185	US11021493, Example 104	Beta-secretase 2			 2.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501185&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135143880	459086539							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043572	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(Br)cn2)cc(F)c1F	InChI=1S/C18H16BrF3N4O2S/c1-18(9-29(27,28)26(2)17(23)25-18)12-5-10(7-14(21)16(12)22)6-13(20)15-4-3-11(19)8-24-15/h3-8H,9H2,1-2H3,(H2,23,25)/b13-6-/t18-/m0/s1	ICCXUMYFLMOMOC-BXIWPEDZSA-N	501186	US11021493, Example 105	Beta-secretase 2			 9.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501186&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125567	459086540							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043576	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C19H17F2N5O2S/c1-19(11-29(27,28)26(2)18(23)25-19)14-7-12(3-5-15(14)20)8-16(21)17-6-4-13(9-22)10-24-17/h3-8,10H,11H2,1-2H3,(H2,23,25)/b16-8-/t19-/m0/s1	RAQAIWXEDMWZOG-ZMHGOHSBSA-N	501187	US11021493, Example 106	Beta-secretase 2			 31.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501187&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125833	459086541							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043580	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)cc(F)c1F	InChI=1S/C19H16F3N5O2S/c1-19(10-30(28,29)27(2)18(24)26-19)13-5-12(7-15(21)17(13)22)6-14(20)16-4-3-11(8-23)9-25-16/h3-7,9H,10H2,1-2H3,(H2,24,26)/b14-6-/t19-/m0/s1	HDKKEPJHRYPLPT-COXIKBTRSA-N	501188	US11021493, Example 107::US11021493, Example 275	Beta-secretase 2			 25.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501188&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126403	459086542							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043584	C[C@@]1(N=C(N)[C@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C23H21F3N4O3S/c1-3-8-33-20-12-28-18(11-29-20)17(26)10-14-4-5-16(25)15(9-14)22(2)19-6-7-23(13-24,21(27)30-22)34(19,31)32/h1,4-5,9-12,19H,6-8,13H2,2H3,(H2,27,30)/b17-10-/t19-,22+,23+/m0/s1	AWROIJICUAAEHH-ITHVVHDKSA-N	501189	US11021493, Example 108	Beta-secretase 2			 57.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501189&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			162370045	459086543							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043588	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C22H20F6N4O3S/c1-20(17-4-5-21(10-23,19(29)32-20)36(17,33)34)13-6-12(2-3-14(13)24)7-15(25)16-8-31-18(9-30-16)35-11-22(26,27)28/h2-3,6-9,17H,4-5,10-11H2,1H3,(H2,29,32)/b15-7-/t17-,20+,21-/m0/s1	LJHVTKLLYRJZCG-KUDAXZBBSA-N	501190	US11021493, Example 109	Beta-secretase 2			 167							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501190&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126335	459086544							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043592	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)C2CCOCC2)cc(F)c1F	InChI=1S/C18H22F3N3O3S/c1-18(10-28(25,26)24(2)17(22)23-18)13-7-11(9-15(20)16(13)21)8-14(19)12-3-5-27-6-4-12/h7-9,12H,3-6,10H2,1-2H3,(H2,22,23)/b14-8-/t18-/m0/s1	LPOHHKYKXSSCQS-PIJNTSGSSA-N	501191	US11021493, Example 110	Beta-secretase 2			 963							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501191&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126373	459086545							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043596	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C17H16ClF2N5O2S/c1-17(9-28(26,27)25(2)16(21)24-17)11-5-10(3-4-12(11)19)6-13(20)14-7-23-15(18)8-22-14/h3-8H,9H2,1-2H3,(H2,21,24)/b13-6-/t17-/m0/s1	XKGVHXNXXZBFGM-LBWZGELYSA-N	501192	US11021493, Example 111::US11021493, Example 143::US11021493, Example 146::US11021493, Example 164	Beta-secretase 2			 5.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501192&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125936	459086546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043600	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C20H19F2N5O3S/c1-4-7-30-18-11-24-17(10-25-18)16(22)9-13-5-6-15(21)14(8-13)20(2)12-31(28,29)27(3)19(23)26-20/h1,5-6,8-11H,7,12H2,2-3H3,(H2,23,26)/b16-9-/t20-/m0/s1	WIQPRGHWWVQNAA-CPYXBQISSA-N	50510765	CHEMBL4440849::US11021493, Example 112	Beta-secretase 2			 52.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510765&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126469	440719347							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043604	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H20F2N4O2S/c1-20(2)19(25)27-21(3,12-30(20,28)29)15-8-13(4-6-16(15)22)9-17(23)18-7-5-14(10-24)11-26-18/h4-9,11H,12H2,1-3H3,(H2,25,27)/b17-9-/t21-/m0/s1	YUWKXSOQJDCMGK-YWUCYRDRSA-N	501194	US11021493, Example 113	Beta-secretase 2			 9.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501194&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126462	459086547							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043608	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H20ClF2N3O2S/c1-19(2)18(24)26-20(3,11-29(19,27)28)14-8-12(4-6-15(14)22)9-16(23)17-7-5-13(21)10-25-17/h4-10H,11H2,1-3H3,(H2,24,26)/b16-9-/t20-/m0/s1	FJUITDHHAAGQMS-CPYXBQISSA-N	501195	US11021493, Example 114	Beta-secretase 2			 3.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501195&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125878	459086548							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043612	Cc1noc(COc2cnc(cn2)C(\F)=C\c2ccc(F)c(c2)[C@@]2(C)N=C(N)[C@@]3(CF)CC[C@@H]2S3(=O)=O)n1	InChI=1S/C24H23F3N6O4S/c1-13-31-21(37-33-13)11-36-20-10-29-18(9-30-20)17(27)8-14-3-4-16(26)15(7-14)23(2)19-5-6-24(12-25,22(28)32-23)38(19,34)35/h3-4,7-10,19H,5-6,11-12H2,1-2H3,(H2,28,32)/b17-8-/t19-,23+,24-/m0/s1	BIWTUBYUFSMDPH-AUXROIDUSA-N	501196	US11021493, Example 115	Beta-secretase 2			 192							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501196&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125146	459086549							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043616	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3ncco3)cn2)ccc1F	InChI=1S/C21H20F2N6O4S/c1-21(12-34(30,31)29(2)20(24)28-21)14-7-13(3-4-15(14)22)8-16(23)17-9-27-18(10-26-17)33-11-19-25-5-6-32-19/h3-10H,11-12H2,1-2H3,(H2,24,28)/b16-8-/t21-/m0/s1	LLBSPEOFGKBDBA-NSUHCSJYSA-N	501197	US11021493, Example 116	Beta-secretase 2			 45.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501197&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125026	459086550							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043620	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C19H18F5N5O3S/c1-18(10-33(30,31)29(2)17(25)28-18)12-5-11(3-4-13(12)20)6-14(21)15-7-27-16(8-26-15)32-9-19(22,23)24/h3-8H,9-10H2,1-2H3,(H2,25,28)/b14-6-/t18-/m0/s1	RDNMEHDDDNNOIV-AGOXUQQWSA-N	501198	US11021493, Example 117	Beta-secretase 2			 186							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501198&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125176	459086551							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043624	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3CC3)cn2)ccc1F	InChI=1S/C24H25F3N4O3S/c1-23(20-6-7-24(13-25,22(28)31-23)35(20,32)33)16-8-15(4-5-17(16)26)9-18(27)19-10-30-21(11-29-19)34-12-14-2-3-14/h4-5,8-11,14,20H,2-3,6-7,12-13H2,1H3,(H2,28,31)/b18-9-/t20-,23+,24-/m0/s1	CRXXNYQVRSNKDH-AWTRGSECSA-N	501199	US11021493, Example 118	Beta-secretase 2			 124							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501199&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126094	459086552							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043628	Cc1nnc(COc2cnc(cn2)C(\F)=C\c2ccc(F)c(c2)[C@@]2(C)N=C(N)[C@@]3(CF)CC[C@@H]2S3(=O)=O)o1	InChI=1S/C24H23F3N6O4S/c1-13-32-33-21(37-13)11-36-20-10-29-18(9-30-20)17(27)8-14-3-4-16(26)15(7-14)23(2)19-5-6-24(12-25,22(28)31-23)38(19,34)35/h3-4,7-10,19H,5-6,11-12H2,1-2H3,(H2,28,31)/b17-8-/t19-,23+,24-/m0/s1	DYHDADCBPLWMDC-AUXROIDUSA-N	501200	US11021493, Example 119	Beta-secretase 2			 182							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501200&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126379	459086553							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043632	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)(F)C(F)F)cn2)ccc1F	InChI=1S/C23H21F7N4O3S/c1-21(17-4-5-22(10-24,20(31)34-21)38(17,35)36)13-6-12(2-3-14(13)25)7-15(26)16-8-33-18(9-32-16)37-11-23(29,30)19(27)28/h2-3,6-9,17,19H,4-5,10-11H2,1H3,(H2,31,34)/b15-7-/t17-,21+,22-/m0/s1	BMXSKNRBEYELFD-JURDMDRRSA-N	501201	US11021493, Example 120	Beta-secretase 2			 258							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501201&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125583	459086554							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043636	COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O	InChI=1S/C21H21F3N4O3S/c1-20(17-5-6-21(11-22,19(25)28-20)32(17,29)30)13-7-12(3-4-14(13)23)8-15(24)16-9-27-18(31-2)10-26-16/h3-4,7-10,17H,5-6,11H2,1-2H3,(H2,25,28)/b15-8-/t17-,20+,21-/m0/s1	JZNZMADVBGQCLW-NZUJZPRYSA-N	501202	US11021493, Example 121	Beta-secretase 2			 180							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501202&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125929	459086555							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043640	CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O	InChI=1S/C22H23F3N4O3S/c1-3-32-19-11-27-17(10-28-19)16(25)9-13-4-5-15(24)14(8-13)21(2)18-6-7-22(12-23,20(26)29-21)33(18,30)31/h4-5,8-11,18H,3,6-7,12H2,1-2H3,(H2,26,29)/b16-9-/t18-,21+,22-/m0/s1	TWWUHNNXXQQLLR-LLYJTOGPSA-N	501203	US11021493, Example 122	Beta-secretase 2			 194							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501203&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125944	459086556							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043644	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H22F2N4O3S/c1-5-8-31-19-12-26-18(11-27-19)17(24)10-14-6-7-16(23)15(9-14)22(4)13-32(29,30)21(2,3)20(25)28-22/h1,6-7,9-12H,8,13H2,2-4H3,(H2,25,28)/b17-10-/t22-/m0/s1	MAJFETMMCMCMPJ-VBBNHBBTSA-N	50510783	CHEMBL4470897::US11021493, Example 123	Beta-secretase 2			 51.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50510783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50510783&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125856	440719365							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043648	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)(F)F)cn2)ccc1F	InChI=1S/C21H21F5N4O3S/c1-19(2)18(27)30-20(3,11-34(19,31)32)13-6-12(4-5-14(13)22)7-15(23)16-8-29-17(9-28-16)33-10-21(24,25)26/h4-9H,10-11H2,1-3H3,(H2,27,30)/b15-7-/t20-/m0/s1	APCLACYAMMYMOQ-BRAWNXGXSA-N	501205	US11021493, Example 124	Beta-secretase 2			 161							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501205&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125930	459086557							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043652	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC=C)cn2)ccc1F	InChI=1S/C23H23F3N4O3S/c1-3-8-33-20-12-28-18(11-29-20)17(26)10-14-4-5-16(25)15(9-14)22(2)19-6-7-23(13-24,21(27)30-22)34(19,31)32/h3-5,9-12,19H,1,6-8,13H2,2H3,(H2,27,30)/b17-10-/t19-,22+,23-/m0/s1	YOXNDBJZZCDOTE-NKUXOPIZSA-N	501206	US11021493, Example 125	Beta-secretase 2			 163							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501206&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125594	459086558							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043656	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3COC3)cn2)ccc1F	InChI=1S/C24H25F3N4O4S/c1-23(20-4-5-24(13-25,22(28)31-23)36(20,32)33)16-6-14(2-3-17(16)26)7-18(27)19-8-30-21(9-29-19)35-12-15-10-34-11-15/h2-3,6-9,15,20H,4-5,10-13H2,1H3,(H2,28,31)/b18-7-/t20-,23+,24-/m0/s1	RLCPZPOURNLVTM-WJFAUYEISA-N	501207	US11021493, Example 126	Beta-secretase 2			 141							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501207&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125175	459086559							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043660	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3ccc(cn3)C#N)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C21H19F2N5O2S/c1-20(21(7-8-21)31(29,30)28(2)19(25)27-20)15-9-13(3-5-16(15)22)10-17(23)18-6-4-14(11-24)12-26-18/h3-6,9-10,12H,7-8H2,1-2H3,(H2,25,27)/b17-10-/t20-/m1/s1	BBNKDWRNDBPTOR-PLMLNFJUSA-N	501208	US11021493, Example 127	Beta-secretase 2			 175							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501208&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125537	459086560							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043664	C[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)C#C	InChI=1S/C24H23F3N4O3S/c1-4-14(2)34-21-12-29-19(11-30-21)18(27)10-15-5-6-17(26)16(9-15)23(3)20-7-8-24(13-25,22(28)31-23)35(20,32)33/h1,5-6,9-12,14,20H,7-8,13H2,2-3H3,(H2,28,31)/b18-10-/t14-,20-,23+,24-/m0/s1	OFMNRFWBSOZHFP-CMMCLEBZSA-N	501209	US11021493, Example 128	Beta-secretase 2			 147							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501209&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126328	459086561							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043668	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3ncco3)cn2)ccc1F	InChI=1S/C23H23F2N5O4S/c1-22(2)21(26)30-23(3,13-35(22,31)32)15-8-14(4-5-16(15)24)9-17(25)18-10-29-19(11-28-18)34-12-20-27-6-7-33-20/h4-11H,12-13H2,1-3H3,(H2,26,30)/b17-9-/t23-/m0/s1	QDOBYRKWCWCKSV-KEPADWISSA-N	501210	US11021493, Example 129	Beta-secretase 2			 56.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501210&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125803	459086562							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043672	COCCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O	InChI=1S/C23H25F3N4O4S/c1-22(19-5-6-23(13-24,21(27)30-22)35(19,31)32)15-9-14(3-4-16(15)25)10-17(26)18-11-29-20(12-28-18)34-8-7-33-2/h3-4,9-12,19H,5-8,13H2,1-2H3,(H2,27,30)/b17-10-/t19-,22+,23-/m0/s1	IAWXEYRMEHILFM-NKUXOPIZSA-N	501211	US11021493, Example 130	Beta-secretase 2			 163							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501211&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126144	459086563							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043676	COC[C@H](C)Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O	InChI=1S/C24H27F3N4O4S/c1-14(12-34-3)35-21-11-29-19(10-30-21)18(27)9-15-4-5-17(26)16(8-15)23(2)20-6-7-24(13-25,22(28)31-23)36(20,32)33/h4-5,8-11,14,20H,6-7,12-13H2,1-3H3,(H2,28,31)/b18-9-/t14-,20-,23+,24-/m0/s1	RNCAMBODGPZNAW-ZOYCZNOASA-N	501212	US11021493, Example 131	Beta-secretase 2			 104							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501212&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126451	459086564							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043680	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3CCC3)cn2)ccc1F	InChI=1S/C25H27F3N4O3S/c1-24(21-7-8-25(14-26,23(29)32-24)36(21,33)34)17-9-16(5-6-18(17)27)10-19(28)20-11-31-22(12-30-20)35-13-15-3-2-4-15/h5-6,9-12,15,21H,2-4,7-8,13-14H2,1H3,(H2,29,32)/b19-10-/t21-,24+,25-/m0/s1	GBLGGQWJQJVMRT-XCZGQCRVSA-N	501213	US11021493, Example 132	Beta-secretase 2			 217							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501213&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125248	459086565							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043684	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCCF)cn2)ccc1F	InChI=1S/C22H22F4N4O3S/c1-21(18-4-5-22(12-24,20(27)30-21)34(18,31)32)14-8-13(2-3-15(14)25)9-16(26)17-10-29-19(11-28-17)33-7-6-23/h2-3,8-11,18H,4-7,12H2,1H3,(H2,27,30)/b16-9-/t18-,21+,22-/m0/s1	AKNYYQPERGPUHJ-LLYJTOGPSA-N	501214	US11021493, Example 133	Beta-secretase 2			 151							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501214&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125726	459086566							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043688	C[C@@]1(N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)F)cn2)ccc1F	InChI=1S/C22H21F5N4O3S/c1-21(17-4-5-22(11-23,20(28)31-21)35(17,32)33)13-6-12(2-3-14(13)24)7-15(25)16-8-30-19(9-29-16)34-10-18(26)27/h2-3,6-9,17-18H,4-5,10-11H2,1H3,(H2,28,31)/b15-7-/t17-,21+,22-/m0/s1	QPIIZHRZZDNOGS-JURDMDRRSA-N	501215	US11021493, Example 134	Beta-secretase 2			 123							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501215&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125681	459086567							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043692	CCCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O	InChI=1S/C23H25F3N4O3S/c1-3-8-33-20-12-28-18(11-29-20)17(26)10-14-4-5-16(25)15(9-14)22(2)19-6-7-23(13-24,21(27)30-22)34(19,31)32/h4-5,9-12,19H,3,6-8,13H2,1-2H3,(H2,27,30)/b17-10-/t19-,22+,23-/m0/s1	HFDHAAAQGHEMJE-NKUXOPIZSA-N	501216	US11021493, Example 135	Beta-secretase 2			 120							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501216&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125000	459086568							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043696	COC(C)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O	InChI=1S/C24H27F3N4O4S/c1-14(34-3)12-35-21-11-29-19(10-30-21)18(27)9-15-4-5-17(26)16(8-15)23(2)20-6-7-24(13-25,22(28)31-23)36(20,32)33/h4-5,8-11,14,20H,6-7,12-13H2,1-3H3,(H2,28,31)/b18-9-/t14?,20-,23+,24-/m0/s1	CTZGUXODPFMCQQ-ANIOONFHSA-N	501217	US11021493, Example 136	Beta-secretase 2			 315							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501217&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126119	459086569							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043700	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@]2(CF)CC[C@@H]1S2(=O)=O	InChI=1S/C24H23F3N4O3S/c1-3-4-9-34-21-13-29-19(12-30-21)18(27)11-15-5-6-17(26)16(10-15)23(2)20-7-8-24(14-25,22(28)31-23)35(20,32)33/h5-6,10-13,20H,7-9,14H2,1-2H3,(H2,28,31)/b18-11-/t20-,23+,24-/m0/s1	MFITYXXWNTVXIF-JXOCDECTSA-N	501218	US11021493, Example 137	Beta-secretase 2			 44.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501218&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125686	459086570							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043704	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(OCC#C)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C22H21F2N5O3S/c1-4-9-32-19-13-26-18(12-27-19)17(24)11-14-5-6-16(23)15(10-14)21(2)22(7-8-22)33(30,31)29(3)20(25)28-21/h1,5-6,10-13H,7-9H2,2-3H3,(H2,25,28)/b17-11-/t21-/m1/s1	QCYDNORLXYCIKG-DGJFXRHUSA-N	501219	US11021493, Example 138	Beta-secretase 2			 622							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501219&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125882	459086571							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043708	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18ClF2N5O2S/c1-18(19(5-6-19)30(28,29)27(2)17(23)26-18)12-7-11(3-4-13(12)21)8-14(22)15-9-25-16(20)10-24-15/h3-4,7-10H,5-6H2,1-2H3,(H2,23,26)/b14-8-/t18-/m1/s1	SVTNCINHMKABHR-DVNIYVAHSA-N	501220	US11021493, Example 139::US11021493, Example 147::US11021493, Example 161::US11021493, Example 162::US11021493, Example 163::US11021493, Example 169	Beta-secretase 2			 70.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125041	459086572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043712	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3CC3)cn2)ccc1F	InChI=1S/C23H26F2N4O3S/c1-22(2)21(26)29-23(3,13-33(22,30)31)16-8-15(6-7-17(16)24)9-18(25)19-10-28-20(11-27-19)32-12-14-4-5-14/h6-11,14H,4-5,12-13H2,1-3H3,(H2,26,29)/b18-9-/t23-/m0/s1	WUKZYTGLWVNUQN-UOQNSFNTSA-N	501221	US11021493, Example 140::US11021493, Example 206	Beta-secretase 2			 203							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125448	459086573							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043716	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)(F)C(F)F)cn2)ccc1F	InChI=1S/C22H22F6N4O3S/c1-20(2)19(29)32-21(3,11-36(20,33)34)13-6-12(4-5-14(13)23)7-15(24)16-8-31-17(9-30-16)35-10-22(27,28)18(25)26/h4-9,18H,10-11H2,1-3H3,(H2,29,32)/b15-7-/t21-/m0/s1	NSGTWWITSMDGNM-HVMJPGQCSA-N	501222	US11021493, Example 141	Beta-secretase 2			 330							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501222&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126015	459086574							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043720	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCCC(F)(F)F)cn2)ccc1F	InChI=1S/C22H23F5N4O3S/c1-20(2)19(28)31-21(3,12-35(20,32)33)14-8-13(4-5-15(14)23)9-16(24)17-10-30-18(11-29-17)34-7-6-22(25,26)27/h4-5,8-11H,6-7,12H2,1-3H3,(H2,28,31)/b16-9-/t21-/m0/s1	VVDGHQXYLSRMAE-PMABOMALSA-N	501223	US11021493, Example 142	Beta-secretase 2			 425							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501223&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125796	459086575							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043724	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C17H16ClF2N5O2S/c1-17(9-28(26,27)25(2)16(21)24-17)11-5-10(3-4-12(11)19)6-13(20)14-7-23-15(18)8-22-14/h3-8H,9H2,1-2H3,(H2,21,24)/b13-6-/t17-/m0/s1	XKGVHXNXXZBFGM-LBWZGELYSA-N	501192	US11021493, Example 111::US11021493, Example 143::US11021493, Example 146::US11021493, Example 164	Beta-secretase 2			 222							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501192&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125936	459086546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043728	CC1(C)C(NC(=O)OCC2CCCC2)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3CCCC3)cn2)ccc1F	InChI=1S/C32H40F2N4O5S/c1-31(2)29(37-30(39)43-19-22-10-6-7-11-22)38-32(3,20-44(31,40)41)24-14-23(12-13-25(24)33)15-26(34)27-16-36-28(17-35-27)42-18-21-8-4-5-9-21/h12-17,21-22H,4-11,18-20H2,1-3H3,(H,37,38,39)/b26-15-/t32-/m0/s1	HHBVICWPVVUFCB-LFEOVITLSA-N	501225	US11021493, Example 144	Beta-secretase 2			 143							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501225&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135143912	459086576							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043732	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3CCCC3)cn2)ccc1F	InChI=1S/C25H30F2N4O3S/c1-24(2)23(28)31-25(3,15-35(24,32)33)18-10-17(8-9-19(18)26)11-20(27)21-12-30-22(13-29-21)34-14-16-6-4-5-7-16/h8-13,16H,4-7,14-15H2,1-3H3,(H2,28,31)/b20-11-/t25-/m0/s1	HPOGOBXWTBVPBR-FLYZOPQXSA-N	501226	US11021493, Example 145	Beta-secretase 2			 107							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501226&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126297	459086577							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043736	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C17H16ClF2N5O2S/c1-17(9-28(26,27)25(2)16(21)24-17)11-5-10(3-4-12(11)19)6-13(20)14-7-23-15(18)8-22-14/h3-8H,9H2,1-2H3,(H2,21,24)/b13-6-/t17-/m0/s1	XKGVHXNXXZBFGM-LBWZGELYSA-N	501192	US11021493, Example 111::US11021493, Example 143::US11021493, Example 146::US11021493, Example 164	Beta-secretase 2			 97.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501192&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125936	459086546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043740	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18ClF2N5O2S/c1-18(19(5-6-19)30(28,29)27(2)17(23)26-18)12-7-11(3-4-13(12)21)8-14(22)15-9-25-16(20)10-24-15/h3-4,7-10H,5-6H2,1-2H3,(H2,23,26)/b14-8-/t18-/m1/s1	SVTNCINHMKABHR-DVNIYVAHSA-N	501220	US11021493, Example 139::US11021493, Example 147::US11021493, Example 161::US11021493, Example 162::US11021493, Example 163::US11021493, Example 169	Beta-secretase 2			 184							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125041	459086572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043744	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC(F)(F)C(F)F)cn2)ccc1F	InChI=1S/C20H19F6N5O3S/c1-19(10-35(32,33)31(2)18(27)30-19)12-5-11(3-4-13(12)21)6-14(22)15-7-29-16(8-28-15)34-9-20(25,26)17(23)24/h3-8,17H,9-10H2,1-2H3,(H2,27,30)/b14-6-/t19-/m0/s1	CXUMXNSBNNATPZ-COXIKBTRSA-N	501229	US11021493, Example 148	Beta-secretase 2			 217							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501229&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125591	459086578							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043748	C[C@]1(CS(=O)(=O)C2(CCC2)C(N)=N1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C23H22F2N4O3S/c1-3-9-32-20-13-27-19(12-28-20)18(25)11-15-5-6-17(24)16(10-15)22(2)14-33(30,31)23(7-4-8-23)21(26)29-22/h1,5-6,10-13H,4,7-9,14H2,2H3,(H2,26,29)/b18-11-/t22-/m0/s1	QYCDSDXRBNJUEM-OAIBDCNXSA-N	501230	US11021493, Example 149	Beta-secretase 2			 51.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501230&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126393	459086579							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043752	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3CCCCC3)cn2)ccc1F	InChI=1S/C26H32F2N4O3S/c1-25(2)24(29)32-26(3,16-36(25,33)34)19-11-18(9-10-20(19)27)12-21(28)22-13-31-23(14-30-22)35-15-17-7-5-4-6-8-17/h9-14,17H,4-8,15-16H2,1-3H3,(H2,29,32)/b21-12-/t26-/m0/s1	IOWBZOMWBOXADA-VLXPNXCBSA-N	501231	US11021493, Example 150	Beta-secretase 2			 155							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501231&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125948	459086580							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043756	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C18H16ClF3N4O2S/c1-18(9-29(27,28)26(2)17(23)25-18)12-5-10(7-14(21)16(12)22)6-13(20)15-4-3-11(19)8-24-15/h3-8H,9H2,1-2H3,(H2,23,25)/b13-6-/t18-/m0/s1	LDHMSPBNLUGPKX-BXIWPEDZSA-N	501232	(R,E)-3-amino-5-(5-(2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2,3-difluorophenyl)-2,5-dimethyl-5,6-dihydro-2H-1,2,4-thiadiazine 1,1-dioxide; and::US11021493, Example 151::US11021493, Example 152	Beta-secretase 2			 121							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501232&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126175	459086581							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043760	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(Cl)cn2)cc(F)c1F	InChI=1S/C18H16ClF3N4O2S/c1-18(9-29(27,28)26(2)17(23)25-18)12-5-10(7-14(21)16(12)22)6-13(20)15-4-3-11(19)8-24-15/h3-8H,9H2,1-2H3,(H2,23,25)/b13-6-/t18-/m0/s1	LDHMSPBNLUGPKX-BXIWPEDZSA-N	501232	(R,E)-3-amino-5-(5-(2-(5-chloropyridin-2-yl)-2-fluorovinyl)-2,3-difluorophenyl)-2,5-dimethyl-5,6-dihydro-2H-1,2,4-thiadiazine 1,1-dioxide; and::US11021493, Example 151::US11021493, Example 152	Beta-secretase 2			 6.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501232&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126175	459086581							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043764	CC(C)(COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#N	InChI=1S/C24H27F2N5O3S/c1-22(2,12-27)13-34-20-11-29-19(10-30-20)18(26)9-15-6-7-17(25)16(8-15)24(5)14-35(32,33)23(3,4)21(28)31-24/h6-11H,13-14H2,1-5H3,(H2,28,31)/b18-9-/t24-/m0/s1	CGHXEXGJKJGEQE-WVDNMSGXSA-N	501234	US11021493, Example 153	Beta-secretase 2			 1060							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501234&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125631	459086582							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043768	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C23H24F2N4O3S/c1-5-6-9-32-20-13-27-19(12-28-20)18(25)11-15-7-8-17(24)16(10-15)23(4)14-33(30,31)22(2,3)21(26)29-23/h7-8,10-13H,9,14H2,1-4H3,(H2,26,29)/b18-11-/t23-/m0/s1	DSWMKUAMCWTEKL-RXATWSHQSA-N	501235	US11021493, Example 154	Beta-secretase 2			 34.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501235&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126139	459086583							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043772	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCCn3ccnc3)cn2)ccc1F	InChI=1S/C24H26F2N6O3S/c1-23(2)22(27)31-24(3,14-36(23,33)34)17-10-16(4-5-18(17)25)11-19(26)20-12-30-21(13-29-20)35-9-8-32-7-6-28-15-32/h4-7,10-13,15H,8-9,14H2,1-3H3,(H2,27,31)/b19-11-/t24-/m0/s1	FHCYHUXVOJOSFM-AYUSBESLSA-N	501236	US11021493, Example 155	Beta-secretase 2			 2390							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501236&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126368	459086584							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043776	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCCn3cc(Br)cn3)cn2)ccc1F	InChI=1S/C24H25BrF2N6O3S/c1-23(2)22(28)32-24(3,14-37(23,34)35)17-8-15(4-5-18(17)26)9-19(27)20-11-30-21(12-29-20)36-7-6-33-13-16(25)10-31-33/h4-5,8-13H,6-7,14H2,1-3H3,(H2,28,32)/b19-9-/t24-/m0/s1	PLXUUUAENJWVFY-CEDFBSMGSA-N	501237	US11021493, Example 156::US11021493, Example 157	Beta-secretase 2			 671							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125657	459086585							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043780	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCCn3cc(Br)cn3)cn2)ccc1F	InChI=1S/C24H25BrF2N6O3S/c1-23(2)22(28)32-24(3,14-37(23,34)35)17-8-15(4-5-18(17)26)9-19(27)20-11-30-21(12-29-20)36-7-6-33-13-16(25)10-31-33/h4-5,8-13H,6-7,14H2,1-3H3,(H2,28,32)/b19-9-/t24-/m0/s1	PLXUUUAENJWVFY-CEDFBSMGSA-N	501237	US11021493, Example 156::US11021493, Example 157	Beta-secretase 2			 478							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501237&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125657	459086585							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043784	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)cc(F)c1F	InChI=1S/C17H15ClF3N5O2S/c1-17(8-29(27,28)26(2)16(22)25-17)10-3-9(5-12(20)15(10)21)4-11(19)13-6-24-14(18)7-23-13/h3-7H,8H2,1-2H3,(H2,22,25)/b11-4-/t17-/m0/s1	BJAINYSMFWDFJZ-OSCZDJLXSA-N	501239	US11021493, Example 158	Beta-secretase 2			 31.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501239&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125598	459086586							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043788	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C19H19ClF2N4O2S/c1-18(2)17(23)26-19(3,10-29(18,27)28)12-6-11(4-5-13(12)21)7-14(22)15-8-25-16(20)9-24-15/h4-9H,10H2,1-3H3,(H2,23,26)/b14-7-/t19-/m0/s1	PYRDHKWVKUYQAH-MWNFOORISA-N	501240	US11021493, Example 159	Beta-secretase 2			 3.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501240&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125035	459086587							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043792	C[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#C	InChI=1S/C23H24F2N4O3S/c1-6-14(2)32-20-12-27-19(11-28-20)18(25)10-15-7-8-17(24)16(9-15)23(5)13-33(30,31)22(3,4)21(26)29-23/h1,7-12,14H,13H2,2-5H3,(H2,26,29)/b18-10-/t14-,23-/m0/s1	HJRRATSHBYTWBD-XKUBVJQTSA-N	501241	US11021493, Example 160::US11021493, Example 171	Beta-secretase 2			 120							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125680	459086588							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043796	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18ClF2N5O2S/c1-18(19(5-6-19)30(28,29)27(2)17(23)26-18)12-7-11(3-4-13(12)21)8-14(22)15-9-25-16(20)10-24-15/h3-4,7-10H,5-6H2,1-2H3,(H2,23,26)/b14-8-/t18-/m1/s1	SVTNCINHMKABHR-DVNIYVAHSA-N	501220	US11021493, Example 139::US11021493, Example 147::US11021493, Example 161::US11021493, Example 162::US11021493, Example 163::US11021493, Example 169	Beta-secretase 2			 2630							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125041	459086572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043800	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18ClF2N5O2S/c1-18(19(5-6-19)30(28,29)27(2)17(23)26-18)12-7-11(3-4-13(12)21)8-14(22)15-9-25-16(20)10-24-15/h3-4,7-10H,5-6H2,1-2H3,(H2,23,26)/b14-8-/t18-/m1/s1	SVTNCINHMKABHR-DVNIYVAHSA-N	501220	US11021493, Example 139::US11021493, Example 147::US11021493, Example 161::US11021493, Example 162::US11021493, Example 163::US11021493, Example 169	Beta-secretase 2			 732							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125041	459086572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043804	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18ClF2N5O2S/c1-18(19(5-6-19)30(28,29)27(2)17(23)26-18)12-7-11(3-4-13(12)21)8-14(22)15-9-25-16(20)10-24-15/h3-4,7-10H,5-6H2,1-2H3,(H2,23,26)/b14-8-/t18-/m1/s1	SVTNCINHMKABHR-DVNIYVAHSA-N	501220	US11021493, Example 139::US11021493, Example 147::US11021493, Example 161::US11021493, Example 162::US11021493, Example 163::US11021493, Example 169	Beta-secretase 2			 2880							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125041	459086572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043808	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C17H16ClF2N5O2S/c1-17(9-28(26,27)25(2)16(21)24-17)11-5-10(3-4-12(11)19)6-13(20)14-7-23-15(18)8-22-14/h3-8H,9H2,1-2H3,(H2,21,24)/b13-6-/t17-/m0/s1	XKGVHXNXXZBFGM-LBWZGELYSA-N	501192	US11021493, Example 111::US11021493, Example 143::US11021493, Example 146::US11021493, Example 164	Beta-secretase 2			 108							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501192&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125936	459086546							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043812	CC#CCOc1cnc(cn1)C(\F)=C\c1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C21H20F3N5O3S/c1-4-5-6-32-18-11-26-17(10-27-18)15(22)8-13-7-14(19(24)16(23)9-13)21(2)12-33(30,31)29(3)20(25)28-21/h7-11H,6,12H2,1-3H3,(H2,25,28)/b15-8-/t21-/m0/s1	WTKQJNKMIICWFI-JHHPEZKVSA-N	501246	US11021493, Example 165	Beta-secretase 2			 47.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501246&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126435	459086589							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043816	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3ncco3)cn2)cc(F)c1F	InChI=1S/C21H19F3N6O4S/c1-21(11-35(31,32)30(2)20(25)29-21)13-5-12(7-15(23)19(13)24)6-14(22)16-8-28-17(9-27-16)34-10-18-26-3-4-33-18/h3-9H,10-11H2,1-2H3,(H2,25,29)/b14-6-/t21-/m0/s1	LIGPEDYCRLXVKG-XLPSYMGOSA-N	501247	US11021493, Example 166	Beta-secretase 2			 90.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501247&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125911	459086590							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043820	C[C@H](Oc1cnc(cn1)C(\F)=C\c1cc(F)c(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1)C#C	InChI=1S/C21H20F3N5O3S/c1-5-12(2)32-18-10-26-17(9-27-18)15(22)7-13-6-14(19(24)16(23)8-13)21(3)11-33(30,31)29(4)20(25)28-21/h1,6-10,12H,11H2,2-4H3,(H2,25,28)/b15-7-/t12-,21-/m0/s1	KRUFNKSTSLXHAF-IFIJVCIQSA-N	501248	US11021493, Example 167	Beta-secretase 2			 290							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501248&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126108	459086591							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043824	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C21H21F2N5O3S/c1-4-5-8-31-19-12-25-18(11-26-19)17(23)10-14-6-7-16(22)15(9-14)21(2)13-32(29,30)28(3)20(24)27-21/h6-7,9-12H,8,13H2,1-3H3,(H2,24,27)/b17-10-/t21-/m0/s1	OHAPAGNWIJPFAM-OIOSCTRGSA-N	501249	US11021493, Example 168	Beta-secretase 2			 10.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501249&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126298	459086592							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043828	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C2(CC2)S1(=O)=O	InChI=1S/C19H18ClF2N5O2S/c1-18(19(5-6-19)30(28,29)27(2)17(23)26-18)12-7-11(3-4-13(12)21)8-14(22)15-9-25-16(20)10-24-15/h3-4,7-10H,5-6H2,1-2H3,(H2,23,26)/b14-8-/t18-/m1/s1	SVTNCINHMKABHR-DVNIYVAHSA-N	501220	US11021493, Example 139::US11021493, Example 147::US11021493, Example 161::US11021493, Example 162::US11021493, Example 163::US11021493, Example 169	Beta-secretase 2			 907							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501220&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125041	459086572							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043832	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(cn2)C#N)ccc1F	InChI=1S/C20H19F2N5O2S/c1-19(2)18(24)27-20(3,11-30(19,28)29)14-6-12(4-5-15(14)21)7-16(22)17-10-25-13(8-23)9-26-17/h4-7,9-10H,11H2,1-3H3,(H2,24,27)/b16-7-/t20-/m0/s1	UJZXDTOBDWUJSM-YYFKYVOKSA-N	501251	US11021493, Example 170	Beta-secretase 2			 17.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501251&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125725	459086593							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043836	C[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#C	InChI=1S/C23H24F2N4O3S/c1-6-14(2)32-20-12-27-19(11-28-20)18(25)10-15-7-8-17(24)16(9-15)23(5)13-33(30,31)22(3,4)21(26)29-23/h1,7-12,14H,13H2,2-5H3,(H2,26,29)/b18-10-/t14-,23-/m0/s1	HJRRATSHBYTWBD-XKUBVJQTSA-N	501241	US11021493, Example 160::US11021493, Example 171	Beta-secretase 2			 142							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501241&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125680	459086588							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043840	COC(C)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C23H28F2N4O4S/c1-14(32-5)12-33-20-11-27-19(10-28-20)18(25)9-15-6-7-17(24)16(8-15)23(4)13-34(30,31)22(2,3)21(26)29-23/h6-11,14H,12-13H2,1-5H3,(H2,26,29)/b18-9-/t14?,23-/m0/s1	XITXSPNULANOFE-NGUFGGHJSA-N	501253	US11021493, Example 172	Beta-secretase 2			 84.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501253&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			162370046	459086594							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043844	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nnc(C)o3)cn2)ccc1F	InChI=1S/C21H21F2N7O4S/c1-12-28-29-19(34-12)10-33-18-9-25-17(8-26-18)16(23)7-13-4-5-15(22)14(6-13)21(2)11-35(31,32)30(3)20(24)27-21/h4-9H,10-11H2,1-3H3,(H2,24,27)/b16-7-/t21-/m0/s1	YQKXMIXGTDOFGL-KGSBYCFNSA-N	501254	US11021493, Example 173	Beta-secretase 2			 103							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501254&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125863	459086595							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043848	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(CC3CCC3)cn2)ccc1F	InChI=1S/C24H28F2N4O2S/c1-23(2)22(27)30-24(3,14-33(23,31)32)18-10-16(7-8-19(18)25)11-20(26)21-13-28-17(12-29-21)9-15-5-4-6-15/h7-8,10-13,15H,4-6,9,14H2,1-3H3,(H2,27,30)/b20-11-/t24-/m0/s1	KBBAXWFMKCNDOT-NORABOHISA-N	501255	US11021493, Example 174	Beta-secretase 2			 113							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501255&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			162370047	459086596							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043852	Cc1noc(COc2cnc(cn2)C(\F)=C\c2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C(C)(C)C(N)=N2)n1	InChI=1S/C23H24F2N6O4S/c1-13-29-20(35-31-13)11-34-19-10-27-18(9-28-19)17(25)8-14-5-6-16(24)15(7-14)23(4)12-36(32,33)22(2,3)21(26)30-23/h5-10H,11-12H2,1-4H3,(H2,26,30)/b17-8-/t23-/m0/s1	GXLKQUWFCPVUFB-GFLLXWSHSA-N	501256	US11021493, Example 175	Beta-secretase 2			 225							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501256&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126287	459086597							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043856	Cc1nnc(COc2cnc(cn2)C(\F)=C\c2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C(C)(C)C(N)=N2)o1	InChI=1S/C23H24F2N6O4S/c1-13-30-31-20(35-13)11-34-19-10-27-18(9-28-19)17(25)8-14-5-6-16(24)15(7-14)23(4)12-36(32,33)22(2,3)21(26)29-23/h5-10H,11-12H2,1-4H3,(H2,26,29)/b17-8-/t23-/m0/s1	SXCBJHXUAARZQO-GFLLXWSHSA-N	501257	US11021493, Example 176	Beta-secretase 2			 409							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501257&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125169	459086598							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043860	CC[C@@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#C	InChI=1S/C24H26F2N4O3S/c1-6-16(7-2)33-21-13-28-20(12-29-21)19(26)11-15-8-9-18(25)17(10-15)24(5)14-34(31,32)23(3,4)22(27)30-24/h1,8-13,16H,7,14H2,2-5H3,(H2,27,30)/b19-11-/t16-,24-/m0/s1	NLPJNTRVQWYDNT-QQMPJMTPSA-N	501258	(R)-5-amino-3-(2-fluoro-5-((Z)-2-fluoro-2-(5-((R)-pent-1-yn-3-yloxy)pyrazin-2-yl)vinyl)phenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide; and::US11021493, Example 177	Beta-secretase 2			 101							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501258&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125857	459086599							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043864	CC[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#C	InChI=1S/C24H26F2N4O3S/c1-6-16(7-2)33-21-13-28-20(12-29-21)19(26)11-15-8-9-18(25)17(10-15)24(5)14-34(31,32)23(3,4)22(27)30-24/h1,8-13,16H,7,14H2,2-5H3,(H2,27,30)/b19-11-/t16-,24+/m1/s1	NLPJNTRVQWYDNT-RVNHIENGSA-N	501259	US11021493, Example 178	Beta-secretase 2			 232							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501259&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125158	459086600							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043868	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3COC3)cn2)ccc1F	InChI=1S/C21H23F2N5O4S/c1-21(12-33(29,30)28(2)20(24)27-21)15-5-13(3-4-16(15)22)6-17(23)18-7-26-19(8-25-18)32-11-14-9-31-10-14/h3-8,14H,9-12H2,1-2H3,(H2,24,27)/b17-6-/t21-/m0/s1	WBRXXNXHEOFRHH-KVUYCWINSA-N	501260	US11021493, Example 179	Beta-secretase 2			 217							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501260&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125962	459086601							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043872	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3ccc(cn3)C#N)ccc2F)C(C)(C)S1(=O)=O	InChI=1S/C21H21F2N5O2S/c1-20(2)21(3,27-19(25)28(4)31(20,29)30)15-9-13(5-7-16(15)22)10-17(23)18-8-6-14(11-24)12-26-18/h5-10,12H,1-4H3,(H2,25,27)/b17-10-/t21-/m1/s1	QEYADQLWMCYXIK-SYEXPRJDSA-N	501261	US11021493, Example 180	Beta-secretase 2			 75.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501261&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125902	459086602							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043876	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(cn3)C#N)ccc2F)C(C)(C)S1(=O)=O	InChI=1S/C20H20F2N6O2S/c1-19(2)20(3,27-18(24)28(4)31(19,29)30)14-7-12(5-6-15(14)21)8-16(22)17-11-25-13(9-23)10-26-17/h5-8,10-11H,1-4H3,(H2,24,27)/b16-8-/t20-/m1/s1	DMTMESPCPCYRAA-ATPWARJRSA-N	501262	US11021493, Example 181	Beta-secretase 2			 87.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501262&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125939	459086603							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043880	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C(C)(C)S1(=O)=O	InChI=1S/C19H20ClF2N5O2S/c1-18(2)19(3,26-17(23)27(4)30(18,28)29)12-7-11(5-6-13(12)21)8-14(22)15-9-25-16(20)10-24-15/h5-10H,1-4H3,(H2,23,26)/b14-8-/t19-/m1/s1	JFCZXXJLXOPJMI-YXZIBZLCSA-N	501263	US11021493, Example 182	Beta-secretase 2			 76.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501263&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125665	459086604							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043884	CN1C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(OCC#C)cn3)ccc2F)C(C)(C)S1(=O)=O	InChI=1S/C22H23F2N5O3S/c1-6-9-32-19-13-26-18(12-27-19)17(24)11-14-7-8-16(23)15(10-14)22(4)21(2,3)33(30,31)29(5)20(25)28-22/h1,7-8,10-13H,9H2,2-5H3,(H2,25,28)/b17-11-/t22-/m1/s1	KDVQLADDYCIUTD-CJBPROBKSA-N	501264	US11021493, Example 183	Beta-secretase 2			 678							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501264&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125028	459086605							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043888	CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)C1=N[C@@](C)(CS(=O)(=O)C1(C)C)c1cc(ccc1F)B1OC(C)(C)C(C)(C)O1	InChI=1S/C29H44BFN2O8S/c1-24(2,3)38-22(34)33(23(35)39-25(4,5)6)21-26(7,8)42(36,37)17-29(13,32-21)19-16-18(14-15-20(19)31)30-40-27(9,10)28(11,12)41-30/h14-16H,17H2,1-13H3/t29-/m0/s1	UVWXWBAYFVEZFX-LJAQVGFWSA-N	501265	US11021493, Example 184	Beta-secretase 2			 790							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501265&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			142379413	459086606							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043892	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)N(C)S(=O)(=O)C1(C)C	InChI=1S/C23H25F2N5O3S/c1-6-7-10-33-20-14-27-19(13-28-20)18(25)12-15-8-9-17(24)16(11-15)23(4)22(2,3)34(31,32)30(5)21(26)29-23/h8-9,11-14H,10H2,1-5H3,(H2,26,29)/b18-12-/t23-/m1/s1	GITRIHOLBUKCBI-KELOHDTKSA-N	501266	US11021493, Example 185	Beta-secretase 2			 159							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501266&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125444	459086607							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043896	C[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@@]1(C)N=C(N)N(C)S(=O)(=O)C1(C)C)C#C	InChI=1S/C23H25F2N5O3S/c1-7-14(2)33-20-13-27-19(12-28-20)18(25)11-15-8-9-17(24)16(10-15)23(5)22(3,4)34(31,32)30(6)21(26)29-23/h1,8-14H,2-6H3,(H2,26,29)/b18-11-/t14-,23+/m0/s1	CPXPAHAUMSSSPU-IHJZIOCDSA-N	501267	US11021493, Example 186	Beta-secretase 2			 451							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501267&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125692	459086608							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043900	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc3OCCOc3cn2)ccc1F	InChI=1S/C20H20F2N4O4S/c1-20(11-31(27,28)26(2)19(23)25-20)13-7-12(3-4-14(13)21)8-15(22)16-9-17-18(10-24-16)30-6-5-29-17/h3-4,7-10H,5-6,11H2,1-2H3,(H2,23,25)/b15-8-/t20-/m0/s1	OSQAZQUQGDXQMJ-SLPYIPCOSA-N	501268	US11021493, Example 187	Beta-secretase 2			 78.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501268&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125777	459086609							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043904	CC1(C)C(N)=N[C@@](CF)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F	InChI=1S/C21H19F3N4O2S/c1-20(2)19(26)28-21(11-22,12-31(20,29)30)15-7-13(3-5-16(15)23)8-17(24)18-6-4-14(9-25)10-27-18/h3-8,10H,11-12H2,1-2H3,(H2,26,28)/b17-8-/t21-/m0/s1	MGXHOZFRCAHSIL-NLOKWTDQSA-N	501269	US11021493, Example 188	Beta-secretase 2			 57.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501269&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126473	459086610							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043908	CC1(C)C(N)=N[C@@](CF)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)ccc1F	InChI=1S/C19H18ClF3N4O2S/c1-18(2)17(24)27-19(9-21,10-30(18,28)29)12-5-11(3-4-13(12)22)6-14(23)15-7-26-16(20)8-25-15/h3-8H,9-10H2,1-2H3,(H2,24,27)/b14-6-/t19-/m0/s1	FCUVGJUTFWKTDD-COXIKBTRSA-N	501270	US11021493, Example 189	Beta-secretase 2			 59.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501270&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125173	459086611							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043912	CC1(C)C(N)=N[C@@](CF)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H21F3N4O3S/c1-4-7-32-19-11-27-18(10-28-19)17(25)9-14-5-6-16(24)15(8-14)22(12-23)13-33(30,31)21(2,3)20(26)29-22/h1,5-6,8-11H,7,12-13H2,2-3H3,(H2,26,29)/b17-9-/t22-/m0/s1	RXBIUOSYSOGINZ-IFRKUXIOSA-N	501271	US11021493, Example 190	Beta-secretase 2			 274							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501271&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125533	459086612							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043916	CC1(C)C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(Cl)cn3)ccc2F)C(F)(F)S1(=O)=O	InChI=1S/C19H17ClF4N4O2S/c1-17(2)16(25)28-18(3,19(23,24)31(17,29)30)11-6-10(4-5-12(11)21)7-13(22)14-8-27-15(20)9-26-14/h4-9H,1-3H3,(H2,25,28)/b13-7-/t18-/m1/s1	HEUJXUTVZDSLGX-MEVIEEELSA-N	501272	US11021493, Example 191	Beta-secretase 2			 52.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501272	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501272&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126397	459086613							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043920	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)cc(F)c1F	InChI=1S/C21H19F3N4O2S/c1-20(2)19(26)28-21(3,11-31(20,29)30)14-6-13(8-16(23)18(14)24)7-15(22)17-5-4-12(9-25)10-27-17/h4-8,10H,11H2,1-3H3,(H2,26,28)/b15-7-/t21-/m0/s1	BQVXXVMHASLYMT-HVMJPGQCSA-N	501273	US11021493, Example 192	Beta-secretase 2			 46.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501273	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501273&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126388	459086614							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043924	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)cc(F)c1F	InChI=1S/C19H18ClF3N4O2S/c1-18(2)17(24)27-19(3,9-30(18,28)29)11-4-10(6-13(22)16(11)23)5-12(21)14-7-26-15(20)8-25-14/h4-8H,9H2,1-3H3,(H2,24,27)/b12-5-/t19-/m0/s1	IEPNSQMIJLNBIV-RSSRPAAFSA-N	501274	US11021493, Example 193	Beta-secretase 2			 104							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501274	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501274&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125864	459086615							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043928	CC#CCOc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(CF)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C23H23F3N4O3S/c1-4-5-8-33-20-12-28-19(11-29-20)18(26)10-15-6-7-17(25)16(9-15)23(13-24)14-34(31,32)22(2,3)21(27)30-23/h6-7,9-12H,8,13-14H2,1-3H3,(H2,27,30)/b18-10-/t23-/m0/s1	BMAFGXFXMDCLOZ-ASDHTPKVSA-N	501275	US11021493, Example 194	Beta-secretase 2			 181							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501275	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501275&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126385	459086616							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043932	C[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(CF)CS(=O)(=O)C(C)(C)C(N)=N1)C#C	InChI=1S/C23H23F3N4O3S/c1-5-14(2)33-20-11-28-19(10-29-20)18(26)9-15-6-7-17(25)16(8-15)23(12-24)13-34(31,32)22(3,4)21(27)30-23/h1,6-11,14H,12-13H2,2-4H3,(H2,27,30)/b18-9-/t14-,23-/m0/s1	GQABEEYCEOAKHE-QJQVHLTKSA-N	501276	US11021493, Example 195	Beta-secretase 2			 523							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501276	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501276&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125122	459086617							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043936	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc3OCCOc3c2)ccc1F	InChI=1S/C21H21F2N3O4S/c1-21(12-31(27,28)26(2)20(24)25-21)15-9-13(3-5-16(15)22)10-17(23)14-4-6-18-19(11-14)30-8-7-29-18/h3-6,9-11H,7-8,12H2,1-2H3,(H2,24,25)/b17-10-/t21-/m0/s1	MTRWBNJJZRXCMU-OIOSCTRGSA-N	501277	US11021493, Example 196	Beta-secretase 2			 157							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501277	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501277&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125722	459086618							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043940	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cn2)C#N)cnc1F	InChI=1S/C20H19F2N5O2S/c1-19(2)18(24)27-20(3,11-30(19,28)29)14-6-13(10-26-17(14)22)7-15(21)16-5-4-12(8-23)9-25-16/h4-7,9-10H,11H2,1-3H3,(H2,24,27)/b15-7-/t20-/m0/s1	ATPOVJHUZIGURY-BRAWNXGXSA-N	501278	US11021493, Example 197	Beta-secretase 2			 87.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501278	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501278&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126315	459086619							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043944	CC[C@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#CC	InChI=1S/C25H28F2N4O3S/c1-6-8-17(7-2)34-22-14-29-21(13-30-22)20(27)12-16-9-10-19(26)18(11-16)25(5)15-35(32,33)24(3,4)23(28)31-25/h9-14,17H,7,15H2,1-5H3,(H2,28,31)/b20-12-/t17-,25-/m0/s1	MLEKTTLBVUPCRL-FPXLDRQJSA-N	501279	(R)-5-amino-3-(2-fluoro-5-((Z)-2-fluoro-2-(5-((R)-hex-4-yn-3-yloxy)pyrazin-2-yl)vinyl)phenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide; and::US11021493, Example 198	Beta-secretase 2			 371							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501279	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501279&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125155	459086620							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043948	CC[C@@H](Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1)C#CC	InChI=1S/C25H28F2N4O3S/c1-6-8-17(7-2)34-22-14-29-21(13-30-22)20(27)12-16-9-10-19(26)18(11-16)25(5)15-35(32,33)24(3,4)23(28)31-25/h9-14,17H,7,15H2,1-5H3,(H2,28,31)/b20-12-/t17-,25+/m1/s1	MLEKTTLBVUPCRL-YZTODZFBSA-N	501280	US11021493, Example 199	Beta-secretase 2			 102							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501280	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501280&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125006	459086621							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043952	CC1(C)C(N)=N[C@@](C)([C@H](F)S1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H21F3N4O3S/c1-5-8-32-18-12-27-17(11-28-18)16(24)10-13-6-7-15(23)14(9-13)22(4)19(25)33(30,31)21(2,3)20(26)29-22/h1,6-7,9-12,19H,8H2,2-4H3,(H2,26,29)/b16-10-/t19-,22-/m1/s1	YAFQXDBLHCFXJR-YYCVMSQUSA-N	501281	US11021493, Example 200	Beta-secretase 2			 86.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501281	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501281&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125650	459086622							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043956	CC1(C)C(N)=N[C@@](C)([C@@H](F)S1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F	InChI=1S/C22H21F3N4O3S/c1-5-8-32-18-12-27-17(11-28-18)16(24)10-13-6-7-15(23)14(9-13)22(4)19(25)33(30,31)21(2,3)20(26)29-22/h1,6-7,9-12,19H,8H2,2-4H3,(H2,26,29)/b16-10-/t19-,22+/m0/s1	YAFQXDBLHCFXJR-RFVWLHOTSA-N	501282	US11021493, Example 201	Beta-secretase 2			 82.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501282	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501282&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125153	459086623							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043960	CC1(C)C(N)=N[C@](C)(c2cc(\C=C(/F)c3cnc(OCC#C)cn3)ccc2F)C(F)(F)S1(=O)=O	InChI=1S/C22H20F4N4O3S/c1-5-8-33-18-12-28-17(11-29-18)16(24)10-13-6-7-15(23)14(9-13)21(4)22(25,26)34(31,32)20(2,3)19(27)30-21/h1,6-7,9-12H,8H2,2-4H3,(H2,27,30)/b16-10-/t21-/m1/s1	NYZZLTLFKINVOG-KGGGBHMPSA-N	501283	US11021493, Example 202	Beta-secretase 2			 870							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501283	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501283&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125151	459086624							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043964	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Cl)cn2)cnc1F	InChI=1S/C18H18ClF2N5O2S/c1-17(2)16(22)26-18(3,9-29(17,27)28)11-4-10(6-25-15(11)21)5-12(20)13-7-24-14(19)8-23-13/h4-8H,9H2,1-3H3,(H2,22,26)/b12-5-/t18-/m0/s1	OUOPNPINCNXCMK-KYDJUPTOSA-N	501284	US11021493, Example 203	Beta-secretase 2			 56.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501284&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125646	459086625							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043968	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cc(F)c1F	InChI=1S/C22H21F3N4O3S/c1-5-6-32-18-11-27-17(10-28-18)15(23)8-13-7-14(19(25)16(24)9-13)22(4)12-33(30,31)21(2,3)20(26)29-22/h1,7-11H,6,12H2,2-4H3,(H2,26,29)/b15-8-/t22-/m0/s1	XONQBONHVGVWMR-YDBYVANFSA-N	501285	US11021493, Example 204	Beta-secretase 2			 179							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501285&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125701	459086626							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043972	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)cnc1F	InChI=1S/C21H21F2N5O3S/c1-5-6-31-17-11-25-16(10-26-17)15(22)8-13-7-14(18(23)27-9-13)21(4)12-32(29,30)20(2,3)19(24)28-21/h1,7-11H,6,12H2,2-4H3,(H2,24,28)/b15-8-/t21-/m0/s1	NYVDAVLLNYHSII-JHHPEZKVSA-N	501286	US11021493, Example 205	Beta-secretase 2			 129							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501286&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126446	459086627							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043976	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC3CC3)cn2)ccc1F	InChI=1S/C23H26F2N4O3S/c1-22(2)21(26)29-23(3,13-33(22,30)31)16-8-15(6-7-17(16)24)9-18(25)19-10-28-20(11-27-19)32-12-14-4-5-14/h6-11,14H,4-5,12-13H2,1-3H3,(H2,26,29)/b18-9-/t23-/m0/s1	WUKZYTGLWVNUQN-UOQNSFNTSA-N	501221	US11021493, Example 140::US11021493, Example 206	Beta-secretase 2			 139							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501221&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125448	459086573							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043980	CC#C[C@H](C)Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C24H26F2N4O3S/c1-6-7-15(2)33-21-13-28-20(12-29-21)19(26)11-16-8-9-18(25)17(10-16)24(5)14-34(31,32)23(3,4)22(27)30-24/h8-13,15H,14H2,1-5H3,(H2,27,30)/b19-11-/t15-,24-/m0/s1	UULZRQYJOWPKGT-OJNDDCHJSA-N	501288	(R)-5-amino-3-(2-fluoro-5-((Z)-2-fluoro-2-(5-((R)-pent-3-yn-2-yloxy)pyrazin-2-yl)vinyl)phenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide; and::US11021493, Example 207	Beta-secretase 2			 519							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501288	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501288&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125860	459086628							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043984	CC#C[C@@H](C)Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C24H26F2N4O3S/c1-6-7-15(2)33-21-13-28-20(12-29-21)19(26)11-16-8-9-18(25)17(10-16)24(5)14-34(31,32)23(3,4)22(27)30-24/h8-13,15H,14H2,1-5H3,(H2,27,30)/b19-11-/t15-,24+/m1/s1	UULZRQYJOWPKGT-MHZFSLMJSA-N	501289	US11021493, Example 208	Beta-secretase 2			 107							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501289&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125789	459086629							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043988	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3ccccc3)cn2)cnc1F	InChI=1S/C25H25F2N5O3S/c1-24(2)23(28)32-25(3,15-36(24,33)34)18-9-17(11-31-22(18)27)10-19(26)20-12-30-21(13-29-20)35-14-16-7-5-4-6-8-16/h4-13H,14-15H2,1-3H3,(H2,28,32)/b19-10-/t25-/m0/s1	CXICJNDGGFNJCW-HGDKGACMSA-N	501290	US11021493, Example 209	Beta-secretase 2			 311							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501290&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125635	459086630							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043992	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3ccncc3)cn2)ccc1F	InChI=1S/C25H25F2N5O3S/c1-24(2)23(28)32-25(3,15-36(24,33)34)18-10-17(4-5-19(18)26)11-20(27)21-12-31-22(13-30-21)35-14-16-6-8-29-9-7-16/h4-13H,14-15H2,1-3H3,(H2,28,32)/b20-11-/t25-/m0/s1	WSDOPEDHECVJSF-FLYZOPQXSA-N	501291	US11021493, Example 210	Beta-secretase 2			 476							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501291	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501291&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125931	459086631							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1043996	CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(Oc3ccccc3)cn2)ccc1F	InChI=1S/C25H24F2N4O3S/c1-24(2)23(28)31-25(3,15-35(24,32)33)18-11-16(9-10-19(18)26)12-20(27)21-13-30-22(14-29-21)34-17-7-5-4-6-8-17/h4-14H,15H2,1-3H3,(H2,28,31)/b20-12-/t25-/m0/s1	OHCQZOYURJKSAS-NIAMQAJOSA-N	501292	US11021493, Example 211	Beta-secretase 2			 333							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501292	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501292&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125711	459086632							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044000	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ccc(cc2)C#N)ccc1F	InChI=1S/C20H18F2N4O2S/c1-20(12-29(27,28)26(2)19(24)25-20)16-9-14(5-8-17(16)21)10-18(22)15-6-3-13(11-23)4-7-15/h3-10H,12H2,1-2H3,(H2,24,25)/b18-10-/t20-/m0/s1	HPWHBXBGZYSHGZ-JYWRCUDFSA-N	501293	US11021493, Example 212	Beta-secretase 2			 132							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501293	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501293&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125014	459086633							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044004	CC1(C)C(N)=N[C@@](C)([C@H](F)S1(=O)=O)c1cc(\C=C(/F)c2cc3OCCOc3cn2)ccc1F	InChI=1S/C22H22F3N3O4S/c1-21(2)20(26)28-22(3,19(25)33(21,29)30)13-8-12(4-5-14(13)23)9-15(24)16-10-17-18(11-27-16)32-7-6-31-17/h4-5,8-11,19H,6-7H2,1-3H3,(H2,26,28)/b15-9-/t19-,22-/m1/s1	DNKLRRSVLUYVBB-CSXVTCHCSA-N	501294	US11021493, Example 213	Beta-secretase 2			 683							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501294&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125147	459086634							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044008	CC1(C)C(N)=N[C@@](C)([C@@H](F)S1(=O)=O)c1cc(\C=C(/F)c2cc3OCCOc3cn2)ccc1F	InChI=1S/C22H22F3N3O4S/c1-21(2)20(26)28-22(3,19(25)33(21,29)30)13-8-12(4-5-14(13)23)9-15(24)16-10-17-18(11-27-16)32-7-6-31-17/h4-5,8-11,19H,6-7H2,1-3H3,(H2,26,28)/b15-9-/t19-,22+/m0/s1	DNKLRRSVLUYVBB-ZPEIHTIZSA-N	501295	US11021493, Example 214	Beta-secretase 2			 851							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501295&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126327	459086635							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044012	CC1(C)C(N)=N[C@](C)(c2cc(\C=C(/F)c3cc4OCCOc4cn3)ccc2F)C(F)(F)S1(=O)=O	InChI=1S/C22H21F4N3O4S/c1-20(2)19(27)29-21(3,22(25,26)34(20,30)31)13-8-12(4-5-14(13)23)9-15(24)16-10-17-18(11-28-16)33-7-6-32-17/h4-5,8-11H,6-7H2,1-3H3,(H2,27,29)/b15-9-/t21-/m1/s1	ISINGNQBVRWZCL-WHIQYKQFSA-N	501296	US11021493, Example 215	Beta-secretase 2			 4025							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501296	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501296&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125166	459086636							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044016	CCC#C[C@H](C)Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C25H28F2N4O3S/c1-6-7-8-16(2)34-22-14-29-21(13-30-22)20(27)12-17-9-10-19(26)18(11-17)25(5)15-35(32,33)24(3,4)23(28)31-25/h9-14,16H,6,15H2,1-5H3,(H2,28,31)/b20-12-/t16-,25-/m0/s1	YUUVAARKFYRVHP-JCSCNGDCSA-N	501297	(R)-5-amino-3-(2-fluoro-5-((Z)-2-fluoro-2-(5-((R)-hex-3-yn-2-yloxy)pyrazin-2-yl)vinyl)phenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide; and::US11021493, Example 216	Beta-secretase 2			 364							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501297	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501297&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126288	459086637							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044020	CCC#C[C@@H](C)Oc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C25H28F2N4O3S/c1-6-7-8-16(2)34-22-14-29-21(13-30-22)20(27)12-17-9-10-19(26)18(11-17)25(5)15-35(32,33)24(3,4)23(28)31-25/h9-14,16H,6,15H2,1-5H3,(H2,28,31)/b20-12-/t16-,25+/m1/s1	YUUVAARKFYRVHP-UESFXIRASA-N	501298	US11021493, Example 217	Beta-secretase 2			 233							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501298&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126022	459086638							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044024	C[C@H](O)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C22H26F2N4O4S/c1-13(29)11-32-19-10-26-18(9-27-19)17(24)8-14-5-6-16(23)15(7-14)22(4)12-33(30,31)21(2,3)20(25)28-22/h5-10,13,29H,11-12H2,1-4H3,(H2,25,28)/b17-8-/t13-,22-/m0/s1	GPVVLPXMVYOABD-VEPZOGOTSA-N	501299	(R)-5-amino-3-(2-fluoro-5-((Z)-2-fluoro-2-(5-(((S)-1-hydroxypropan-2-yl)oxy)pyrazin-2-yl)vinyl)phenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide; and::US11021493, Example 218	Beta-secretase 2			 285							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501299	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501299&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125730	459086639							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044028	C[C@@H](O)COc1cnc(cn1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(N)=N1	InChI=1S/C22H26F2N4O4S/c1-13(29)11-32-19-10-26-18(9-27-19)17(24)8-14-5-6-16(23)15(7-14)22(4)12-33(30,31)21(2,3)20(25)28-22/h5-10,13,29H,11-12H2,1-4H3,(H2,25,28)/b17-8-/t13-,22+/m1/s1	GPVVLPXMVYOABD-WHKCTIBLSA-N	501300	US11021493, Example 219	Beta-secretase 2			 377							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501300&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			162370048	459086640							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044032	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3cscn3)cn2)cc(F)c1F	InChI=1S/C21H19F3N6O3S2/c1-21(10-35(31,32)30(2)20(25)29-21)14-3-12(5-16(23)19(14)24)4-15(22)17-6-27-18(7-26-17)33-8-13-9-34-11-28-13/h3-7,9,11H,8,10H2,1-2H3,(H2,25,29)/b15-4-/t21-/m0/s1	LITNCVQHGBECBC-QWPNKFHKSA-N	501301	US11021493, Example 220	Beta-secretase 2			 66.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501301	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501301&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125768	459086641							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044036	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3cc(C)no3)cn2)cc(F)c1F	InChI=1S/C22H21F3N6O4S/c1-12-4-14(35-30-12)10-34-19-9-27-18(8-28-19)16(23)6-13-5-15(20(25)17(24)7-13)22(2)11-36(32,33)31(3)21(26)29-22/h4-9H,10-11H2,1-3H3,(H2,26,29)/b16-6-/t22-/m0/s1	CIFAGKWFXOQVJD-HLSNCYEYSA-N	501302	US11021493, Example 221	Beta-secretase 2			 197							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501302	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501302&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126150	459086642							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044040	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc(=O)c(Cl)c[nH]2)ccc1F			501303	US11021493, Example 222	Beta-secretase 2			 473							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501303	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501303&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			162370049	459086643							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044044	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3cc(C)on3)cn2)cc(F)c1F	InChI=1S/C22H21F3N6O4S/c1-12-4-14(30-35-12)10-34-19-9-27-18(8-28-19)16(23)6-13-5-15(20(25)17(24)7-13)22(2)11-36(32,33)31(3)21(26)29-22/h4-9H,10-11H2,1-3H3,(H2,26,29)/b16-6-/t22-/m0/s1	BADIUOXXUYVOKP-HLSNCYEYSA-N	501304	US11021493, Example 223	Beta-secretase 2			 210							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501304	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501304&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126402	459086644							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044048	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nc(C)no3)cn2)cc(F)c1F	InChI=1S/C21H20F3N7O4S/c1-11-28-18(35-30-11)9-34-17-8-26-16(7-27-17)14(22)5-12-4-13(19(24)15(23)6-12)21(2)10-36(32,33)31(3)20(25)29-21/h4-8H,9-10H2,1-3H3,(H2,25,29)/b14-5-/t21-/m0/s1	LFNSBYRUOAXDLQ-NZARZLALSA-N	501305	US11021493, Example 224	Beta-secretase 2			 421							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501305	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501305&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126349	459086645							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044052	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3cocn3)cn2)cc(F)c1F	InChI=1S/C21H19F3N6O4S/c1-21(10-35(31,32)30(2)20(25)29-21)14-3-12(5-16(23)19(14)24)4-15(22)17-6-27-18(7-26-17)34-9-13-8-33-11-28-13/h3-8,11H,9-10H2,1-2H3,(H2,25,29)/b15-4-/t21-/m0/s1	KCXVXXPLOOYYTO-QWPNKFHKSA-N	501306	US11021493, Example 225	Beta-secretase 2			 84.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501306	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501306&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125741	459086646							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044056	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc(F)c(cn2)C#N)ccc1F	InChI=1S/C19H16F3N5O2S/c1-19(10-30(28,29)27(2)18(24)26-19)13-5-11(3-4-14(13)20)6-16(22)17-7-15(21)12(8-23)9-25-17/h3-7,9H,10H2,1-2H3,(H2,24,26)/b16-6-/t19-/m0/s1	HONUCVPMRNACEL-ICRRLBEQSA-N	501307	US11021493, Example 226	Beta-secretase 2			 14.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501307	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501307&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125782	459086647							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044060	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCC=C)cn2)cc(F)c1F	InChI=1S/C20H20F3N5O3S/c1-4-5-31-17-10-25-16(9-26-17)14(21)7-12-6-13(18(23)15(22)8-12)20(2)11-32(29,30)28(3)19(24)27-20/h4,6-10H,1,5,11H2,2-3H3,(H2,24,27)/b14-7-/t20-/m0/s1	JBJZYNUUWPWYLZ-HGEVBOJVSA-N	501308	US11021493, Example 227	Beta-secretase 2			 269							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501308	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501308&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126146	459086648							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044064	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3ncccn3)cn2)cc(F)c1F	InChI=1S/C22H20F3N7O3S/c1-22(12-36(33,34)32(2)21(26)31-22)14-6-13(8-16(24)20(14)25)7-15(23)17-9-30-19(10-29-17)35-11-18-27-4-3-5-28-18/h3-10H,11-12H2,1-2H3,(H2,26,31)/b15-7-/t22-/m0/s1	FFDDVJXLKUZNQX-AELLWPAVSA-N	501309	US11021493, Example 228	Beta-secretase 2			 266							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501309&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125801	459086649							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044068	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3noc(C)n3)cn2)cc(F)c1F	InChI=1S/C21H20F3N7O4S/c1-11-28-17(30-35-11)9-34-18-8-26-16(7-27-18)14(22)5-12-4-13(19(24)15(23)6-12)21(2)10-36(32,33)31(3)20(25)29-21/h4-8H,9-10H2,1-3H3,(H2,25,29)/b14-5-/t21-/m0/s1	DVTPPFUEKLSQNQ-NZARZLALSA-N	501310	US11021493, Example 229	Beta-secretase 2			 257							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501310	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501310&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125941	459086650							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044072	COc1cc(ncc1Cl)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C19H19ClF2N4O3S/c1-19(10-30(27,28)26(2)18(23)25-19)12-6-11(4-5-14(12)21)7-15(22)16-8-17(29-3)13(20)9-24-16/h4-9H,10H2,1-3H3,(H2,23,25)/b15-7-/t19-/m0/s1	BKIFKSWYFQGVPM-GDMVIRIFSA-N	501311	US11021493, Example 230	Beta-secretase 2			 24.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501311	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501311&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126465	459086651							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044076	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc(C#N)c(Cl)cn2)ccc1F	InChI=1S/C19H16ClF2N5O2S/c1-19(10-30(28,29)27(2)18(24)26-19)13-5-11(3-4-15(13)21)6-16(22)17-7-12(8-23)14(20)9-25-17/h3-7,9H,10H2,1-2H3,(H2,24,26)/b16-6-/t19-/m0/s1	ZYYATMZPSJFYHR-ICRRLBEQSA-N	501312	US11021493, Example 231	Beta-secretase 2			 94.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501312	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501312&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125685	459086652							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044080	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cc(F)c(Cl)cn2)ccc1F	InChI=1S/C18H16ClF3N4O2S/c1-18(9-29(27,28)26(2)17(23)25-18)11-5-10(3-4-13(11)20)6-15(22)16-7-14(21)12(19)8-24-16/h3-8H,9H2,1-2H3,(H2,23,25)/b15-6-/t18-/m0/s1	XTTRJRCVEFDXIO-HMMSMWIJSA-N	501313	US11021493, Example 232	Beta-secretase 2			 2.00							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501313	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501313&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125836	459086653							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044084	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nnc(C)o3)cn2)cc(F)c1F	InChI=1S/C21H20F3N7O4S/c1-11-29-30-18(35-11)9-34-17-8-26-16(7-27-17)14(22)5-12-4-13(19(24)15(23)6-12)21(2)10-36(32,33)31(3)20(25)28-21/h4-8H,9-10H2,1-3H3,(H2,25,28)/b14-5-/t21-/m0/s1	OUYCDGNQTWUZCZ-NZARZLALSA-N	501314	US11021493, Example 233	Beta-secretase 2			 621							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501314	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501314&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125618	459086654							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044088	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2ncc3OCCOc3n2)ccc1F	InChI=1S/C19H19F2N5O4S/c1-19(10-31(27,28)26(2)18(22)25-19)12-7-11(3-4-13(12)20)8-14(21)16-23-9-15-17(24-16)30-6-5-29-15/h3-4,7-9H,5-6,10H2,1-2H3,(H2,22,25)/b14-8-/t19-/m0/s1	WWZTUSOPZPQIJC-HTJTXACHSA-N	501315	US11021493, Example 234	Beta-secretase 2			 554							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501315	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501315&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125790	459086655							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044092	C[C@@H]1COc2nc(ncc2O1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C20H21F2N5O4S/c1-11-9-30-18-16(31-11)8-24-17(25-18)15(22)7-12-4-5-14(21)13(6-12)20(2)10-32(28,29)27(3)19(23)26-20/h4-8,11H,9-10H2,1-3H3,(H2,23,26)/b15-7-/t11-,20+/m1/s1	HQZGMGTXHGXLEA-UQQCTONMSA-N	501316	US11021493, Example 235	Beta-secretase 2			 533							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501316	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501316&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135125134	459086656							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044096	C[C@H]1COc2cnc(nc2O1)C(\F)=C\c1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)N(C)C(N)=N1	InChI=1S/C20H21F2N5O4S/c1-11-9-30-16-8-24-17(25-18(16)31-11)15(22)7-12-4-5-14(21)13(6-12)20(2)10-32(28,29)27(3)19(23)26-20/h4-8,11H,9-10H2,1-3H3,(H2,23,26)/b15-7-/t11-,20-/m0/s1	UBWQZMAABAARLZ-IAYXEOLASA-N	501317	US11021493, Example 236	Beta-secretase 2			 2355							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501317	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501317&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126407	459086657							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044100	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nc(C)cs3)cn2)cc(F)c1F	InChI=1S/C22H21F3N6O3S2/c1-12-10-35-19(29-12)9-34-18-8-27-17(7-28-18)15(23)5-13-4-14(20(25)16(24)6-13)22(2)11-36(32,33)31(3)21(26)30-22/h4-8,10H,9,11H2,1-3H3,(H2,26,30)/b15-5-/t22-/m0/s1	NZRZQNUNKUYLQK-JARJPIKVSA-N	501318	US11021493, Example 237	Beta-secretase 2			 103							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501318	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501318&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126426	459086658							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1044104	CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(\C=C(/F)c2cnc(OCc3nc(C)oc3C)cn2)cc(F)c1F	InChI=1S/C23H23F3N6O4S/c1-12-19(30-13(2)36-12)10-35-20-9-28-18(8-29-20)16(24)6-14-5-15(21(26)17(25)7-14)23(3)11-37(33,34)32(4)22(27)31-23/h5-9H,10-11H2,1-4H3,(H2,27,31)/b16-6-/t23-/m0/s1	JLBWIPUMAWJKTC-NBQIURKZSA-N	501319	US11021493, Example 238	Beta-secretase 2			 94.0							US Patent		10.7270/Q2CZ3B90		aid1805610	US11021493	Allen, JR; Bourbeau, MP; Brown, JA; Chen, N; Frohn, MJ; Fu, Z; Liu, L; Liu, Q; Pettus, LH; Qian, W; Reeves, C; Siegmund, AC	Amgen Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=501319	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=501319&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			135126442	459086659							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1037746	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1ccccc1F	InChI=1S/C16H21FN2O3S/c1-10-8-13-16(9-22-10,11-6-4-5-7-12(11)17)19-14(18)15(2,3)23(13,20)21/h4-7,10,13H,8-9H2,1-3H3,(H2,18,19)/t10-,13+,16+/m0/s1	DMEDVHXVIZMNTO-OWRWGESLSA-N	448194	US10689401, EX 1::US11008338, Example 1	Beta-secretase 2		 72.5								US Patent		10.7270/Q2RF5Z46		aid1805573	US11008338	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448194&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406873	440710205							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1037747	C[C@@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1ccccc1F	InChI=1S/C16H21FN2O3S/c1-10-8-13-16(9-22-10,11-6-4-5-7-12(11)17)19-14(18)15(2,3)23(13,20)21/h4-7,10,13H,8-9H2,1-3H3,(H2,18,19)/t10-,13-,16-/m1/s1	DMEDVHXVIZMNTO-CKUKBARFSA-N	448195	US10689401, EX 2::US11008338, Example 2	Beta-secretase 2		 6259								US Patent		10.7270/Q2RF5Z46		aid1805573	US11008338	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448195&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406936	440710206							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1037749	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Br)ccc1F	InChI=1S/C16H20BrFN2O3S/c1-9-6-13-16(8-23-9,11-7-10(17)4-5-12(11)18)20-14(19)15(2,3)24(13,21)22/h4-5,7,9,13H,6,8H2,1-3H3,(H2,19,20)/t9-,13+,16+/m0/s1	PWHVSROCXLHTFE-LQBHMHGISA-N	448196	US10689401, EX 3::US11008338, Example 3	Beta-secretase 2		 399								US Patent		10.7270/Q2RF5Z46		aid1805573	US11008338	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448196&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406872	440710207							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1037751	CC(C)COc1ccc(F)c(c1)[C@]12CO[C@@H](C)C[C@H]1S(=O)(=O)C(C)(C)C(=N)N2	InChI=1S/C20H29FN2O4S/c1-12(2)10-26-14-6-7-16(21)15(9-14)20-11-27-13(3)8-17(20)28(24,25)19(4,5)18(22)23-20/h6-7,9,12-13,17H,8,10-11H2,1-5H3,(H2,22,23)/t13-,17+,20+/m0/s1	QUQKAGGARNDCIR-WSXQUGQNSA-N	448197	US10689401, EX 4::US11008338, Example 4	Beta-secretase 2		 31.6								US Patent		10.7270/Q2RF5Z46		aid1805573	US11008338	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448197&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406939	440710208							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1037753	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2ncccc2F)ccc1F	InChI=1S/C21H23F2N3O4S/c1-12-9-17-21(11-29-12,26-19(24)20(2,3)31(17,27)28)14-10-13(6-7-15(14)22)30-18-16(23)5-4-8-25-18/h4-8,10,12,17H,9,11H2,1-3H3,(H2,24,26)/t12-,17+,21+/m0/s1	NUTYXXXZWVAGHN-LKNMKHRSSA-N	448199	US10689401, EX 5::US11008338, Example 5	Beta-secretase 2		 4.90								US Patent		10.7270/Q2RF5Z46		aid1805573	US11008338	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448199&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			137406870	440710210							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1037755	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2cc(ccn2)[N+]#[C-])ccc1F	InChI=1S/C22H23FN4O4S/c1-13-9-18-22(12-30-13,27-20(24)21(2,3)32(18,28)29)16-11-15(5-6-17(16)23)31-19-10-14(25-4)7-8-26-19/h5-8,10-11,13,18H,9,12H2,1-3H3,(H2,24,27)/t13-,18+,22+/m0/s1	XPUYDROMFZLYPA-PFDOBSCMSA-N	498090	US11008338, Example 6	Beta-secretase 2		 19.2								US Patent		10.7270/Q2RF5Z46		aid1805573	US11008338	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=498090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=498090&enzyme=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search			145767562	459071050							1	MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK	2EWY,3ZKM,3ZKN,3ZKQ,3ZKS,4BEL,4BFB,6JSZ,7D5B,7D5U,7F1G,7N4N	Beta-secretase 2	BACE2_HUMAN	Q9Y5Z0	A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6						
1037757	C[C@H]1C[C@@H]2[C@](CO1)(NC(=N)C(C)(C)S2(=O)=O)c1cc(Oc2ncc(F)cc2F)ccc1F	InChI=1S/C21H22F3N3O4S/c1-11-6-17-21(10-30-11,27-19(25)20(2,3)32(17,28)29)14-8-13(4-5-15(14)23)31-18-16(24)7-12(22)9-26-18/h4-5,7-9,11,17H,6,10H2,1-3H3,(H2,25,27)/t11-,17+,21+/m0/s1	SDKJCGRZSMGSBT-PPJNFFCYSA-N	448203	US10689401, EX 7::US11008338, Example 7	Beta-secretase 2		 28.9								US Patent		10.7270/Q2RF5Z46		aid1805573	US11008338	Wu, W; Cumming, JN; Taoka, BM; Dai, X	Merck Sharp & Dohme Corp.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=339&target=Beta-secretase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/db