BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 501233 CCOc1ccc(c(C)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H37FN2O3/c1-3-37-31-15-14-28(22(2)34-31)30-7-4-6-24-20-25(36)10-13-29(24)32(30)23-8-11-26(12-9-23)38-27-16-19-35(21-27)18-5-17-33/h8-15,20,27,36H,3-7,16-19,21H2,1-2H3/t27-/m0/s1 DLFVCFBBFGSEDJ-MHZLTWQESA-N 263792 6-(6- ethoxy-2- methyl-3- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 125 Estrogen receptor [Y537S] 106 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263792&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232765 377002694 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501236 Cn1ccc2cc(ccc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H35FN2O2/c1-35-18-14-26-20-25(8-13-32(26)35)30-5-2-4-24-21-27(37)9-12-31(24)33(30)23-6-10-28(11-7-23)38-29-15-19-36(22-29)17-3-16-34/h6-14,18,20-21,29,37H,2-5,15-17,19,22H2,1H3/t29-/m0/s1 KWOTWNGFDXAJGF-LJAQVGFWSA-N 263793 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1- methyl- indol-5-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 126 Estrogen receptor [Y537S] 541 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263793&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232817 377002695 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501239 Oc1ccc2c(CCCC(c3ccc(Cl)nc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H30ClFN2O2/c30-28-12-7-22(18-32-28)26-4-1-3-21-17-23(34)8-11-27(21)29(26)20-5-9-24(10-6-20)35-25-13-16-33(19-25)15-2-14-31/h5-12,17-18,25,34H,1-4,13-16,19H2/t25-/m0/s1 ONJQJJGJTMUHSE-VWLOTQADSA-N 263794 6-(6- chloro-3- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 127 Estrogen receptor [Y537S] 347 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263794&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232767 377002696 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501242 CNC(=O)c1ccc(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34F2N2O3/c1-35-32(38)29-12-8-23(19-30(29)34)27-5-2-4-22-18-24(37)9-13-28(22)31(27)21-6-10-25(11-7-21)39-26-14-17-36(20-26)16-3-15-33/h6-13,18-19,26,37H,2-5,14-17,20H2,1H3,(H,35,38)/t26-/m0/s1 WPBLAHHCHOUKDX-SANMLTNESA-N 263795 2-fluoro-4- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]-N- methyl- benzamide::US9714221, Example 128 Estrogen receptor [Y537S] 1692 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263795&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232811 377002697 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501245 Oc1ccc2c(CCCC(c3ccc(nc3F)C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H29F5N2O2/c31-14-2-15-37-16-13-23(18-37)39-22-8-5-19(6-9-22)28-24-10-7-21(38)17-20(24)3-1-4-25(28)26-11-12-27(30(33,34)35)36-29(26)32/h5-12,17,23,38H,1-4,13-16,18H2/t23-/m0/s1 IOIQRTZWGHKEST-QHCPKHFHSA-N 263796 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 6-[2- fluoro-6- (trifluoro- methyl)-3- pyridyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 129 Estrogen receptor [Y537S] 290 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263796&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232790 377002698 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501248 Oc1ccc2c(CCCC(c3ccc(OCCF)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H35F2NO3/c33-16-2-18-35-19-15-29(22-35)38-28-12-7-24(8-13-28)32-30(23-5-10-27(11-6-23)37-20-17-34)4-1-3-25-21-26(36)9-14-31(25)32/h5-14,21,29,36H,1-4,15-20,22H2/t29-/m0/s1 PCZSHBWYRKMQAE-LJAQVGFWSA-N 263797 6-[4-(2- fluoro- ethoxy)phenyl]- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 130 Estrogen receptor [Y537S] 44.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263797&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232773 377002699 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501251 CCOc1ccc(c(C)c1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C34H40FNO3/c1-4-38-33-16-15-30(23(2)24(33)3)32-8-5-7-26-21-27(37)11-14-31(26)34(32)25-9-12-28(13-10-25)39-29-17-20-36(22-29)19-6-18-35/h9-16,21,29,37H,4-8,17-20,22H2,1-3H3/t29-/m0/s1 AHIILRCOJSZEIV-LJAQVGFWSA-N 263798 6-(4- ethoxy- 2,3- dimethyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 131 Estrogen receptor [Y537S] 253 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263798&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232810 377002700 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501254 CCOc1ncc(cc1C(F)(F)F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34F4N2O3/c1-2-40-31-29(32(34,35)36)18-23(19-37-31)27-6-3-5-22-17-24(39)9-12-28(22)30(27)21-7-10-25(11-8-21)41-26-13-16-38(20-26)15-4-14-33/h7-12,17-19,26,39H,2-6,13-16,20H2,1H3/t26-/m0/s1 ICRRUNKZNNTNCA-SANMLTNESA-N 263799 6-[6- ethoxy-5- (trifluoro- methyl)-3- pyridyl]-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 132 Estrogen receptor [Y537S] 1249 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263799&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232818 377002701 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501257 CN1CCOc2cc(ccc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H37FN2O3/c1-35-18-19-38-32-21-25(8-13-31(32)35)29-5-2-4-24-20-26(37)9-12-30(24)33(29)23-6-10-27(11-7-23)39-28-14-17-36(22-28)16-3-15-34/h6-13,20-21,28,37H,2-5,14-19,22H2,1H3/t28-/m0/s1 LGAZUQTZNONXHI-NDEPHWFRSA-N 263800 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 6-(4- methyl- 2,3- dihydro- 1,4- benzoxazin- 7-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 133 Estrogen receptor [Y537S] 190 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263800&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233182 377002702 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501260 Oc1ccc2c(CCCC(c3ccc4OC(F)(F)Oc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30F3NO4/c32-14-2-15-35-16-13-25(19-35)37-24-9-5-20(6-10-24)30-26(4-1-3-21-17-23(36)8-11-27(21)30)22-7-12-28-29(18-22)39-31(33,34)38-28/h5-12,17-18,25,36H,1-4,13-16,19H2/t25-/m0/s1 XLGXLDLBOICQPN-VWLOTQADSA-N 263801 6-(2,2- difluoro- 1,3- benzo- dioxol-5-yl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 134 Estrogen receptor [Y537S] 28.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263801&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232777 377002703 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501263 CCN1C(=O)COc2ccc(cc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C34H37FN2O4/c1-2-37-31-20-25(9-14-32(31)40-22-33(37)39)29-6-3-5-24-19-26(38)10-13-30(24)34(29)23-7-11-27(12-8-23)41-28-15-18-36(21-28)17-4-16-35/h7-14,19-20,28,38H,2-6,15-18,21-22H2,1H3/t28-/m0/s1 IRBVCZZMTFCEQU-NDEPHWFRSA-N 263802 4-ethyl-6- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]-1,4- benzoxazin- 3-one::US9714221, Example 135 Estrogen receptor [Y537S] 1226 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263802&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233395 377002704 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501266 Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30ClF4NO3/c32-29-18-24(40-31(34,35)36)10-12-27(29)28-4-1-3-21-17-22(38)7-11-26(21)30(28)20-5-8-23(9-6-20)39-25-13-16-37(19-25)15-2-14-33/h5-12,17-18,25,38H,1-4,13-16,19H2/t25-/m0/s1 GHFDLBASWBDLLR-VWLOTQADSA-N 263803 6-[2- chloro-4- (trifluoro- methoxy)- phenyl]-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 136 Estrogen receptor [Y537S] 134 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263803&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233174 377002705 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501269 Oc1ccc2c(CCCC(c3cc(F)c(OC(F)F)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30F5NO3/c32-12-2-13-37-14-11-24(18-37)39-23-8-5-19(6-9-23)29-25(4-1-3-20-15-22(38)7-10-26(20)29)21-16-27(33)30(28(34)17-21)40-31(35)36/h5-10,15-17,24,31,38H,1-4,11-14,18H2/t24-/m0/s1 DCNNGQARLLCALZ-DEOSSOPVSA-N 263804 6-[4- (difluoro- methoxy)- 3,5- difluoro- phenyl]-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 137 Estrogen receptor [Y537S] 363 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263804&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232757 377002706 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501272 CC(C)(C)c1ccc(cc1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1 InChI=1S/C34H39F2NO2/c1-34(2,3)25-12-8-23(9-13-25)28-6-4-7-30-29(16-17-31(38)33(30)36)32(28)24-10-14-26(15-11-24)39-27-18-21-37(22-27)20-5-19-35/h8-17,27,38H,4-7,18-22H2,1-3H3/t27-/m0/s1 LESYWAIWHKWMRT-MHZLTWQESA-N 263805 6-(4-tert- butylphenyl)- 1-fluoro- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 138 Estrogen receptor [Y537S] 323 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263805&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232763 377002707 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501275 CCOc1cc(C)c(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H37FN2O3/c1-3-37-31-18-22(2)30(20-34-31)29-7-4-6-24-19-25(36)10-13-28(24)32(29)23-8-11-26(12-9-23)38-27-14-17-35(21-27)16-5-15-33/h8-13,18-20,27,36H,3-7,14-17,21H2,1-2H3/t27-/m0/s1 FLDMETDSWRSROJ-MHZLTWQESA-N 263806 6-(6- ethoxy-4- methyl-3- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 139 Estrogen receptor [Y537S] 28.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263806&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232408 377002708 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501278 CCOc1c(F)cc(cc1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34ClF2NO3/c1-2-38-32-29(33)18-23(19-30(32)35)27-6-3-5-22-17-24(37)9-12-28(22)31(27)21-7-10-25(11-8-21)39-26-13-16-36(20-26)15-4-14-34/h7-12,17-19,26,37H,2-6,13-16,20H2,1H3/t26-/m0/s1 UYNBLNFZVOMNMG-SANMLTNESA-N 263807 6-(3- chloro-4- ethoxy-5- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 140 Estrogen receptor [Y537S] 685 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263807&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232824 377002709 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501389 OC(=O)c1ccc2c(CCCC(c3ccc(SC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H31F4NO3S/c33-16-2-17-37-18-15-26(20-37)40-25-10-5-22(6-11-25)30-28(21-7-12-27(13-8-21)41-32(34,35)36)4-1-3-23-19-24(31(38)39)9-14-29(23)30/h5-14,19,26H,1-4,15-18,20H2,(H,38,39)/t26-/m0/s1 HTKKZFHRVQOQBO-SANMLTNESA-N 263850 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methyl- sulfanyl)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 177 Estrogen receptor [Y537S] 29.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263850&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233184 377002752 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501392 Oc1ccc2c(CCCC(c3ccc4ncsc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31FN2O2S/c32-14-2-15-34-16-13-26(19-34)36-25-9-5-21(6-10-25)31-27(23-7-12-29-30(18-23)37-20-33-29)4-1-3-22-17-24(35)8-11-28(22)31/h5-12,17-18,20,26,35H,1-4,13-16,19H2/t26-/m0/s1 AXGAACNXSHVRSF-SANMLTNESA-N 263851 6-(1,3- benzo- thiazol-6-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 178 Estrogen receptor [Y537S] 538 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263851&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232890 377002753 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501395 Cn1nnc2ccc(cc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33FN4O2/c1-35-30-19-23(8-13-29(30)33-34-35)27-5-2-4-22-18-24(37)9-12-28(22)31(27)21-6-10-25(11-7-21)38-26-14-17-36(20-26)16-3-15-32/h6-13,18-19,26,37H,2-5,14-17,20H2,1H3/t26-/m0/s1 QAXZNOTVZRSOMQ-SANMLTNESA-N 263852 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- methyl- benzo- triazol-5- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 179 Estrogen receptor [Y537S] 78.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263852&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232761 377002754 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501398 Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H29ClF5NO3/c32-27-17-21(41-31(35,36)37)9-10-23(27)24-3-1-4-26-25(11-12-28(39)30(26)34)29(24)19-5-7-20(8-6-19)40-22-13-16-38(18-22)15-2-14-33/h5-12,17,22,39H,1-4,13-16,18H2/t22-/m0/s1 YKRUBWBBOPKHRR-QFIPXVFZSA-N 263853 6-[2- chloro-4- (trifluoro- methoxy)- phenyl]-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 180 Estrogen receptor [Y537S] 187 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263853&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232421 377002755 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501401 Cc1cc(ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1)C(C)(C)C InChI=1S/C35H42FNO2/c1-24-21-27(35(2,3)4)11-15-31(24)33-8-5-7-26-22-28(38)12-16-32(26)34(33)25-9-13-29(14-10-25)39-30-17-20-37(23-30)19-6-18-36/h9-16,21-22,30,38H,5-8,17-20,23H2,1-4H3/t30-/m0/s1 GSETZINZRCFYPJ-PMERELPUSA-N 263854 6-(4-tert- butyl-2- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 181 Estrogen receptor [Y537S] 120 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263854&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232823 377002756 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501404 CS(=O)(=O)c1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO4S/c1-39(36,37)26-11-13-28(30(33)19-26)29-5-2-4-22-18-23(35)8-12-27(22)31(29)21-6-9-24(10-7-21)38-25-14-17-34(20-25)16-3-15-32/h6-13,18-19,25,35H,2-5,14-17,20H2,1H3/t25-/m0/s1 PADUPLOQXBZUDV-VWLOTQADSA-N 263855 6-(2-fluoro- 4-methyl- sulfonyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 182 Estrogen receptor [Y537S] 125 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263855&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233180 377002757 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501407 Cc1nocc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C28H31FN2O3/c1-19-27(18-33-30-19)26-5-2-4-21-16-22(32)8-11-25(21)28(26)20-6-9-23(10-7-20)34-24-12-15-31(17-24)14-3-13-29/h6-11,16,18,24,32H,2-5,12-15,17H2,1H3/t24-/m0/s1 HTGCXKNOSYWQJZ-DEOSSOPVSA-N 263856 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- methyl- isoxazol-4-yl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 183 Estrogen receptor [Y537S] 459 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263856&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232379 377002758 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501410 Oc1ccc2c(CCCC(c3ccc(cc3)S(F)(F)(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H31F6NO2S/c31-16-2-17-37-18-15-26(20-37)39-25-10-5-22(6-11-25)30-28(4-1-3-23-19-24(38)9-14-29(23)30)21-7-12-27(13-8-21)40(32,33,34,35)36/h5-14,19,26,38H,1-4,15-18,20H2/t26-/m0/s1 NLGZACIKTBLUOS-SANMLTNESA-N 263857 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (pentafluoro- sulfanyl)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 184 Estrogen receptor [Y537S] 981 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263857&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233352 377002759 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501413 Oc1ccc2c(CCCC(c3ccc(cc3)N3CCOCC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C34H39FN2O3/c35-16-2-17-36-18-15-31(24-36)40-30-12-7-26(8-13-30)34-32(4-1-3-27-23-29(38)11-14-33(27)34)25-5-9-28(10-6-25)37-19-21-39-22-20-37/h5-14,23,31,38H,1-4,15-22,24H2/t31-/m0/s1 SEVXNKJKNVUGJK-HKBQPEDESA-N 263858 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- morpholino phenyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 185 Estrogen receptor [Y537S] 75.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263858&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233408 377002760 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501416 Oc1ccc2c(CCCC(c3ccc(OCC(F)F)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H33F4NO3/c33-14-2-15-37-16-13-26(19-37)40-24-8-5-21(6-9-24)32-27-11-7-23(38)17-22(27)3-1-4-29(32)28-12-10-25(18-30(28)34)39-20-31(35)36/h5-12,17-18,26,31,38H,1-4,13-16,19-20H2/t26-/m0/s1 FNIXBHHYXWZQAI-SANMLTNESA-N 263859 6-[4-(2,2- difluoro- ethoxy)-2- fluoro- phenyl]-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 186 Estrogen receptor [Y537S] 321 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263859&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232808 377002761 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501419 Cn1cnc2cc(ccc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34FN3O2/c1-35-21-34-30-19-24(8-13-31(30)35)28-5-2-4-23-18-25(37)9-12-29(23)32(28)22-6-10-26(11-7-22)38-27-14-17-36(20-27)16-3-15-33/h6-13,18-19,21,27,37H,2-5,14-17,20H2,1H3/t27-/m0/s1 QCMIPEFQNCXADN-MHZLTWQESA-N 263860 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1- methyl- benzimi- dazol-5-yl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 187 Estrogen receptor [Y537S] 16.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263860&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232838 377002762 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501422 Oc1ccc2c(CCCC(c3ccc4oncc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31FN2O3/c32-14-2-15-34-16-13-27(20-34)36-26-9-5-21(6-10-26)31-28(23-7-12-30-24(17-23)19-33-37-30)4-1-3-22-18-25(35)8-11-29(22)31/h5-12,17-19,27,35H,1-4,13-16,20H2/t27-/m0/s1 LHSQTOOKQMKHRY-MHZLTWQESA-N 263890 6-(1,2- benzo- xazol-5-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 188 Estrogen receptor [Y537S] 2414 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263890&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233391 377002778 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501425 Oc1ccc2c(CCCC(c3cc[n+]([O-])cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H31FN2O3/c30-14-2-15-31-16-13-26(20-31)35-25-8-5-22(6-9-25)29-27(21-11-17-32(34)18-12-21)4-1-3-23-19-24(33)7-10-28(23)29/h5-12,17-19,26,33H,1-4,13-16,20H2/t26-/m0/s1 VGXYHPZRWATNRI-SANMLTNESA-N 263891 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1- oxido- pyridin-1- ium-4- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 189 Estrogen receptor [Y537S] 444 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263891&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232836 377002779 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501428 Oc1ccc2c(CCCC(c3ccc(cc3)N3CCCC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C34H39FN2O2/c35-18-4-19-36-22-17-31(24-36)39-30-14-9-26(10-15-30)34-32(6-3-5-27-23-29(38)13-16-33(27)34)25-7-11-28(12-8-25)37-20-1-2-21-37/h7-16,23,31,38H,1-6,17-22,24H2/t31-/m0/s1 SSTIQBKIMVJMRY-HKBQPEDESA-N 263892 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- pyrrolidin-1- ylphenyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 190 Estrogen receptor [Y537S] 4.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263892&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233225 377002780 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501431 Cc1nc2cc(ccc2o1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H33FN2O3/c1-21-34-30-19-24(8-13-31(30)37-21)28-5-2-4-23-18-25(36)9-12-29(23)32(28)22-6-10-26(11-7-22)38-27-14-17-35(20-27)16-3-15-33/h6-13,18-19,27,36H,2-5,14-17,20H2,1H3/t27-/m0/s1 VBRQDBUMWIXAKV-MHZLTWQESA-N 263893 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- methyl- 1,3-benzo- xazol-5-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 191 Estrogen receptor [Y537S] 11.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263893&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232385 377002781 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501434 Cc1nc2ccc(cc2o1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H33FN2O3/c1-21-34-30-13-8-24(19-31(30)37-21)28-5-2-4-23-18-25(36)9-12-29(23)32(28)22-6-10-26(11-7-22)38-27-14-17-35(20-27)16-3-15-33/h6-13,18-19,27,36H,2-5,14-17,20H2,1H3/t27-/m0/s1 TWALZUJVLZRAAU-MHZLTWQESA-N 263894 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- methyl- 1,3- benzo- xazol-6-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 192 Estrogen receptor [Y537S] 516 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263894&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233229 377002782 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501437 Oc1ccc2c(CCCC(c3ccc4nonc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30FN3O3/c31-14-2-15-34-16-13-25(19-34)36-24-9-5-20(6-10-24)30-26(22-7-12-28-29(18-22)33-37-32-28)4-1-3-21-17-23(35)8-11-27(21)30/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 ZKRKQJOJFIDWOE-VWLOTQADSA-N 263895 6-(2,1,3- benzo- xadiazol-5-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 193 Estrogen receptor [Y537S] 38.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263895&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232422 377002783 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501440 Oc1ccc2c(CCCC(c3ccc4nsnc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30FN3O2S/c31-14-2-15-34-16-13-25(19-34)36-24-9-5-20(6-10-24)30-26(22-7-12-28-29(18-22)33-37-32-28)4-1-3-21-17-23(35)8-11-27(21)30/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 LXEOVUSAOPIYLB-VWLOTQADSA-N 263896 6-(2,1,3- benzothia- diazol-5-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 194 Estrogen receptor [Y537S] 34.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263896&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232866 377002784 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501443 Oc1ccc2c(CCCC(c3ccc(cc3)C3COC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C33H36FNO3/c34-16-2-17-35-18-15-30(20-35)38-29-12-9-25(10-13-29)33-31(4-1-3-26-19-28(36)11-14-32(26)33)24-7-5-23(6-8-24)27-21-37-22-27/h5-14,19,27,30,36H,1-4,15-18,20-22H2/t30-/m0/s1 CGIVPLCEMOFPCM-PMERELPUSA-N 263897 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (oxetan-3- yl)phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 195 Estrogen receptor [Y537S] 198 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263897&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232787 377002785 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501446 Oc1ccc2c(CCCC(c3ccc4OC(F)(F)C(F)(F)Oc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H30F5NO4/c33-14-2-15-38-16-13-25(19-38)40-24-9-5-20(6-10-24)30-26(4-1-3-21-17-23(39)8-11-27(21)30)22-7-12-28-29(18-22)42-32(36,37)31(34,35)41-28/h5-12,17-18,25,39H,1-4,13-16,19H2/t25-/m0/s1 VHGSBRMCFQMPBD-VWLOTQADSA-N 263898 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6- (2,2,3,3- tetra- fluoro-1,4- benzo- dioxon-6-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 196 Estrogen receptor [Y537S] 124 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263898&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233390 377002786 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501449 Oc1ccc2c(CCCC(c3ccc4sncc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31FN2O2S/c32-14-2-15-34-16-13-27(20-34)36-26-9-5-21(6-10-26)31-28(23-7-12-30-24(17-23)19-33-37-30)4-1-3-22-18-25(35)8-11-29(22)31/h5-12,17-19,27,35H,1-4,13-16,20H2/t27-/m0/s1 WREIMZOWQPZKQI-MHZLTWQESA-N 263899 6-(1,2- benzo- thiazol-5-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 197 Estrogen receptor [Y537S] 586 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263899&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232382 377002787 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501452 Oc1ccc2c(CCCC(c3ccc(N4CCCCC4)c(F)c3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C35H39F3N2O2/c36-17-5-18-39-21-16-28(23-39)42-27-11-8-24(9-12-27)33-29-13-10-26(41)22-25(29)6-4-7-30(33)31-14-15-32(35(38)34(31)37)40-19-2-1-3-20-40/h8-15,22,28,41H,1-7,16-21,23H2/t28-/m0/s1 NRVLMXNUFVBJJO-NDEPHWFRSA-N 263900 6-[2,3- difluoro-4- (1-piperidyl)- phenyl]-5- [4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 198 Estrogen receptor [Y537S] 15.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263900&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232878 377002788 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501455 Oc1ccc2c(CCCC(c3ccc4ncoc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31FN2O3/c32-14-2-15-34-16-13-26(19-34)37-25-9-5-21(6-10-25)31-27(23-7-12-29-30(18-23)36-20-33-29)4-1-3-22-17-24(35)8-11-28(22)31/h5-12,17-18,20,26,35H,1-4,13-16,19H2/t26-/m0/s1 DFAGMVIBGRLRET-SANMLTNESA-N 263903 6-(1,3- benzo- xazol-6-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 199 Estrogen receptor [Y537S] 3097 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263903&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232833 377002790 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501458 Oc1ccc2c(CCCC(c3ccc4cnoc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31FN2O3/c32-14-2-15-34-16-13-27(20-34)36-26-10-7-21(8-11-26)31-28(23-5-6-24-19-33-37-30(24)18-23)4-1-3-22-17-25(35)9-12-29(22)31/h5-12,17-19,27,35H,1-4,13-16,20H2/t27-/m0/s1 LDKUPQCJUXXVME-MHZLTWQESA-N 263904 6-(1,2- benzo- xazol-6-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 200 Estrogen receptor [Y537S] 74.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263904&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232947 377002791 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501461 CC(F)(F)c1ccc(cc1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34F3NO2/c1-32(34,35)25-10-6-22(7-11-25)29-5-2-4-24-20-26(37)12-15-30(24)31(29)23-8-13-27(14-9-23)38-28-16-19-36(21-28)18-3-17-33/h6-15,20,28,37H,2-5,16-19,21H2,1H3/t28-/m0/s1 KTFUNYSAMHEMGD-NDEPHWFRSA-N 263905 6-[4-(1,1- difluoro- ethyl)phenyl]- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 201 Estrogen receptor [Y537S] 67.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263905&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233385 377002792 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501464 Oc1ccc2c(CCCC(C3=CCOCC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H34FNO3/c30-14-2-15-31-16-11-26(20-31)34-25-8-5-22(6-9-25)29-27(21-12-17-33-18-13-21)4-1-3-23-19-24(32)7-10-28(23)29/h5-10,12,19,26,32H,1-4,11,13-18,20H2/t26-/m0/s1 DLMHVMSWRGSYKV-SANMLTNESA-N 263906 6-(3,6- dihydro- 2H-pyran- 4-yl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6- tetra- hydro- pyran-4-yl- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- hydroxy- cyclohexyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 202 Estrogen receptor [Y537S] 48.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263906&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232782 377002793 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501467 Oc1ccc2c(CCCC(C3CCOCC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H36FNO3/c30-14-2-15-31-16-11-26(20-31)34-25-8-5-22(6-9-25)29-27(21-12-17-33-18-13-21)4-1-3-23-19-24(32)7-10-28(23)29/h5-10,19,21,26,32H,1-4,11-18,20H2/t26-/m0/s1 YNDFRWWVZRGZTR-SANMLTNESA-N 263907 US9714221, Example 203 Estrogen receptor [Y537S] 29.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263907&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232937 377002794 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501470 Oc1ccc2c(CCCC(C3CCC4(CC3)OCCO4)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H40FNO4/c33-16-2-17-34-18-13-28(22-34)38-27-8-5-24(6-9-27)31-29(4-1-3-25-21-26(35)7-10-30(25)31)23-11-14-32(15-12-23)36-19-20-37-32/h5-10,21,23,28,35H,1-4,11-20,22H2/t28-/m0/s1 FCBRYKYOFQESDS-NDEPHWFRSA-N 263908 5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-6-(4-hydroxycyclohexyl)-8,9-dihydro-7H-benzo[7]annulen-2-ol::US9714221, Example 204 Estrogen receptor [Y537S] 187 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263908&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232418 377002795 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501473 Cn1cnc2ccc(cc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34FN3O2/c1-35-21-34-30-13-8-24(19-31(30)35)28-5-2-4-23-18-25(37)9-12-29(23)32(28)22-6-10-26(11-7-22)38-27-14-17-36(20-27)16-3-15-33/h6-13,18-19,21,27,37H,2-5,14-17,20H2,1H3/t27-/m0/s1 DOBFMGJSHFLMQH-MHZLTWQESA-N 263909 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- methyl- benzimi- dazol-5-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 205 Estrogen receptor [Y537S] 374 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263909&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233369 377002796 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501476 Oc1ccc2c(CCCC(c3ccc(cc3)-n3cn[nH]c3=O)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 263910 4-[4-[5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]phenyl]- 1H-1,2,4- triazol-5- one6-(4,4- difluoro- cyclohexen-1- yl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(4,4- difluoro- cyclohexyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 206 Estrogen receptor [Y537S] 39.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263910&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233402 377002797 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501479 Oc1ccc2c(CCCC(C3=CCC(F)(F)CC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H34F3NO2/c31-16-2-17-34-18-13-26(20-34)36-25-8-5-22(6-9-25)29-27(21-11-14-30(32,33)15-12-21)4-1-3-23-19-24(35)7-10-28(23)29/h5-11,19,26,35H,1-4,12-18,20H2/t26-/m0/s1 KQZXVTWMNGISHT-SANMLTNESA-N 263911 US9714221, Example 207 Estrogen receptor [Y537S] 19.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263911&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232338 377002798 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501482 Oc1ccc2c(CCCC(C3CCC(F)(F)CC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H36F3NO2/c31-16-2-17-34-18-13-26(20-34)36-25-8-5-22(6-9-25)29-27(21-11-14-30(32,33)15-12-21)4-1-3-23-19-24(35)7-10-28(23)29/h5-10,19,21,26,35H,1-4,11-18,20H2/t26-/m0/s1 DSEMAKHWUXAHLS-SANMLTNESA-N 263912 US9714221, Example 208 Estrogen receptor [Y537S] 543 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263912&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232375 377002799 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501485 OC(=O)c1ccc2c(CCCC(c3ccc(Cl)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31ClFNO3/c32-25-10-5-21(6-11-25)28-4-1-3-23-19-24(31(35)36)9-14-29(23)30(28)22-7-12-26(13-8-22)37-27-15-18-34(20-27)17-2-16-33/h5-14,19,27H,1-4,15-18,20H2,(H,35,36)/t27-/m0/s1 VIFGVVNHPQYNBJ-MHZLTWQESA-N 263913 6-(4- chloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 209 Estrogen receptor [Y537S] 162 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263913&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232370 377002800 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501488 OC(=O)c1ccc2c(CCCC(c3ccccc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31ClFNO3/c32-29-8-2-1-6-27(29)28-7-3-5-22-19-23(31(35)36)11-14-26(22)30(28)21-9-12-24(13-10-21)37-25-15-18-34(20-25)17-4-16-33/h1-2,6,8-14,19,25H,3-5,7,15-18,20H2,(H,35,36)/t25-/m0/s1 XOVGWMBSIUWRAG-VWLOTQADSA-N 263914 6-(2- chloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 210 Estrogen receptor [Y537S] 443 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263914&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232873 377002801 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501491 OC(=O)c1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H29Cl2F2NO3/c32-20-7-10-23(28(33)17-20)24-3-1-4-26-25(11-12-27(30(26)35)31(37)38)29(24)19-5-8-21(9-6-19)39-22-13-16-36(18-22)15-2-14-34/h5-12,17,22H,1-4,13-16,18H2,(H,37,38)/t22-/m0/s1 HFRYMSMVEPTDBG-QFIPXVFZSA-N 263915 6-(2,4- dichloro- phenyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 211 Estrogen receptor [Y537S] 1111 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263915&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232794 377002802 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501494 OC(=O)c1ccc2c(CCCC(c3ccc(Cl)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H29ClF3NO3/c32-20-7-10-23(28(34)17-20)24-3-1-4-26-25(11-12-27(30(26)35)31(37)38)29(24)19-5-8-21(9-6-19)39-22-13-16-36(18-22)15-2-14-33/h5-12,17,22H,1-4,13-16,18H2,(H,37,38)/t22-/m0/s1 SZYZPCRVRPTQFG-QFIPXVFZSA-N 263916 6-(4- chloro-2- fluoro- phenyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid6-(2- chloro-4- fluoro- phenyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 212 Estrogen receptor [Y537S] 334 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263916&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232800 377002803 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501497 OC(=O)c1ccc2c(CCCC(c3ccc(F)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H29ClF3NO3/c32-28-17-20(34)7-10-23(28)24-3-1-4-26-25(11-12-27(30(26)35)31(37)38)29(24)19-5-8-21(9-6-19)39-22-13-16-36(18-22)15-2-14-33/h5-12,17,22H,1-4,13-16,18H2,(H,37,38)/t22-/m0/s1 JFOUTGXFUZCZJI-QFIPXVFZSA-N 263917 6-(2-chloro-4-fluoro-phenyl)-1-fluoro-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid::US9714221, Example 213 Estrogen receptor [Y537S] 23.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263917&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232925 377002804 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501500 Oc1ccc2c(CCCC(c3ccccc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H32FNO2/c31-17-5-18-32-19-16-27(21-32)34-26-13-10-23(11-14-26)30-28(22-6-2-1-3-7-22)9-4-8-24-20-25(33)12-15-29(24)30/h1-3,6-7,10-15,20,27,33H,4-5,8-9,16-19,21H2/t27-/m0/s1 CGHHEBDKJZDTRQ-MHZLTWQESA-N 263918 9-(4-{[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy}- phenyl]-8- phenyl- 6,7- dihydro- 5H- benzo[7]- annulen-3-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1H- indazol-5- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 214 Estrogen receptor [Y537S] 57.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263918&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232400 377002805 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501503 Oc1ccc2c(CCCC(c3ccc4[nH]ncc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 263919 US9714221, Example 215 Estrogen receptor [Y537S] 431 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263919&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232401 377002806 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501506 OC(=O)c1ccc2c(CCCC(c3cccc(F)c3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30ClF2NO3/c32-30-27(6-2-7-28(30)34)26-5-1-4-21-18-22(31(36)37)10-13-25(21)29(26)20-8-11-23(12-9-20)38-24-14-17-35(19-24)16-3-15-33/h2,6-13,18,24H,1,3-5,14-17,19H2,(H,36,37)/t24-/m0/s1 DOHXNJZDPZLWAD-DEOSSOPVSA-N 263920 6-(2- Chloro-3- fluoro- phenyl)-5- {4-[(S)-1- (3-fluoro- propyl)- pyrrolidin-3- yloxy]- phenyl}-8,9- dihydro- 7H- benzocyclo- heptene-2- carboxylic acid::US9714221, Example 216 Estrogen receptor [Y537S] 632 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263920&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232938 377002807 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501509 OC(=O)c1ccc2c(CCCC(c3ccccc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H32FNO3/c32-17-5-18-33-19-16-27(21-33)36-26-13-10-23(11-14-26)30-28(22-6-2-1-3-7-22)9-4-8-24-20-25(31(34)35)12-15-29(24)30/h1-3,6-7,10-15,20,27H,4-5,8-9,16-19,21H2,(H,34,35)/t27-/m0/s1 XMSTUKYIZUWRLL-MHZLTWQESA-N 263921 5-{4-[(S)-1- (3-Fluoro- propyl)- pyrrolidin-3- yloxy]- phenyl}-6- phenyl- 8,9- dihydro- 7H- benzocyclo- heptene-2- carboxylic acid::US9714221, Example 217 Estrogen receptor [Y537S] 779 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263921&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232956 377002808 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501512 OC(=O)c1ccc2c(CCCC(c3ccc4ocnc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H31FN2O4/c33-14-2-15-35-16-13-26(19-35)39-25-9-5-21(6-10-25)31-27(23-8-12-30-29(18-23)34-20-38-30)4-1-3-22-17-24(32(36)37)7-11-28(22)31/h5-12,17-18,20,26H,1-4,13-16,19H2,(H,36,37)/t26-/m0/s1 SEKKXLWWIRLDCI-SANMLTNESA-N 263922 6- Benzo- oxazol-5-yl-5- {4-[(S)-1- (3-fluoro- propyl)- pyrrolidin-3- yloxy]- phenyl}- 8,9- dihydro- 7H- benzocyclo- heptene-2- carboxylic acid::US9714221, Example 218 Estrogen receptor [Y537S] 1094 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263922&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233399 377002809 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500861 Oc1ccc(cc1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2cc(O)ccc2CCC1 InChI=1S/C30H32FNO3/c31-16-2-17-32-18-15-27(20-32)35-26-13-8-23(9-14-26)30-28(22-5-10-24(33)11-6-22)4-1-3-21-7-12-25(34)19-29(21)30/h5-14,19,27,33-34H,1-4,15-18,20H2/t27-/m0/s1 BOUYTPSKRGKAOB-MHZLTWQESA-N 263664 US9714221, Example 1 Estrogen receptor [Y537S] 22.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263664&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233199 377002567 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500864 Oc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2cc(O)ccc2CCC1 InChI=1S/C30H32FNO3/c31-15-3-16-32-17-14-27(20-32)35-26-12-9-22(10-13-26)30-28(23-5-1-6-24(33)18-23)7-2-4-21-8-11-25(34)19-29(21)30/h1,5-6,8-13,18-19,27,33-34H,2-4,7,14-17,20H2/t27-/m0/s1 WMIPDNARVJCBHO-MHZLTWQESA-N 263665 5-[4-[(3S)- 1-(3- fluoro- propyl)pyrrolidin- 3-yl]oxyphenyl]- 6-(3-hydroxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-3-ol5-[4-[(3S)- 1-(3- fluoro- propyl)pyrrolidin- 3-yl]oxyphenyl]- 6-(1H-indol-5-yl)- 8,9-dihydro- 7H- benzo[7]- annulen-3-ol6-(2- chloro-4- fluoro- phenyl)-5- [4-[(3S)-1- (3-fluoro- propyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-3-ol::US9714221, Example 2 Estrogen receptor [Y537S] 22.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263665&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232417 377002568 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500867 Oc1ccc2CCCC(c3ccc4[nH]ccc4c3)=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c2c1 263666 US9714221, Example 3 Estrogen receptor [Y537S] 139 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263666&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232341 377002569 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500870 Oc1ccc2CCCC(c3ccc(F)cc3Cl)=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c2c1 InChI=1S/C30H30ClF2NO2/c31-29-17-22(33)8-12-26(29)27-4-1-3-20-5-9-23(35)18-28(20)30(27)21-6-10-24(11-7-21)36-25-13-16-34(19-25)15-2-14-32/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 INIXJZYQQPVXOX-VWLOTQADSA-N 263667 US9714221, Example 4 Estrogen receptor [Y537S] 68.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263667&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233196 377002570 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500873 Oc1ccc2c(CCCC(c3ccc(F)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30ClF2NO2/c31-29-18-22(33)7-11-27(29)28-4-1-3-21-17-23(35)8-12-26(21)30(28)20-5-9-24(10-6-20)36-25-13-16-34(19-25)15-2-14-32/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 QHPSZPHKTXKQOO-VWLOTQADSA-N 263668 6-(2- chloro-4- fluoro- phenyl)-5- [4-[(3S)-1- (3-fluoro- propyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 5 Estrogen receptor [Y537S] 21.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263668&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232781 377002571 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500876 Oc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H32FNO3/c31-15-3-16-32-17-14-27(20-32)35-26-11-8-21(9-12-26)30-28(22-4-1-6-24(33)18-22)7-2-5-23-19-25(34)10-13-29(23)30/h1,4,6,8-13,18-19,27,33-34H,2-3,5,7,14-17,20H2/t27-/m0/s1 ZOCIUTOGAXVSTJ-MHZLTWQESA-N 263669 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- hydroxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 6 Estrogen receptor [Y537S] 3.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263669&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233179 377002572 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500879 Cc1c(Cl)cccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33ClFNO2/c1-21-27(6-3-8-30(21)32)29-7-2-5-23-19-24(35)11-14-28(23)31(29)22-9-12-25(13-10-22)36-26-15-18-34(20-26)17-4-16-33/h3,6,8-14,19,26,35H,2,4-5,7,15-18,20H2,1H3/t26-/m0/s1 PIPUDSMQZNGOAJ-SANMLTNESA-N 263670 6-(3- chloro-2- methyl- phenyl)-5- [4-[(3S)-1- (3-fluoro- propyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 7 Estrogen receptor [Y537S] 19.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263670&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233365 377002573 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500882 Oc1ccc2c(CCCC(c3cccc(F)c3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30ClF2NO2/c31-30-27(6-2-7-28(30)33)26-5-1-4-21-18-22(35)10-13-25(21)29(26)20-8-11-23(12-9-20)36-24-14-17-34(19-24)16-3-15-32/h2,6-13,18,24,35H,1,3-5,14-17,19H2/t24-/m0/s1 NDYZJKHNFJVNFB-DEOSSOPVSA-N 263671 6-(2- chloro-3- fluoro- phenyl)-5- [4-[(3S)-1- (3-fluoro- propyl)- pyrrolidin-3- yl]oxyphenyl]- 8,9-dihydro- 7H- benzo[7]- annulen-2-ol6-(2-fluoro- 4-methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin- 3-yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 8 Estrogen receptor [Y537S] 8.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263671&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232895 377002574 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500885 Cc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO2/c1-21-6-12-28(30(33)18-21)29-5-2-4-23-19-24(35)9-13-27(23)31(29)22-7-10-25(11-8-22)36-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 JFBNOOJPWYHFES-SANMLTNESA-N 263672 US9714221, Example 36::US9714221, Example 9 Estrogen receptor [Y537S] 10.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263672&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232796 377002575 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500888 Oc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H31F2NO3/c31-14-2-15-33-16-13-25(19-33)36-24-9-5-20(6-10-24)30-26-11-7-22(34)17-21(26)3-1-4-28(30)27-12-8-23(35)18-29(27)32/h5-12,17-18,25,34-35H,1-4,13-16,19H2/t25-/m0/s1 AWCSUZVTARBILC-VWLOTQADSA-N 263673 6-(2-fluoro- 4-hydroxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- hydroxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 10 Estrogen receptor [Y537S] 3.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263673&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232816 377002576 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500891 Oc1ccc(cc1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H32FNO3/c31-16-2-17-32-18-15-27(20-32)35-26-12-7-22(8-13-26)30-28(21-5-9-24(33)10-6-21)4-1-3-23-19-25(34)11-14-29(23)30/h5-14,19,27,33-34H,1-4,15-18,20H2/t27-/m0/s1 KQTVBMTWQANQJC-MHZLTWQESA-N 263674 US9714221, Example 11 Estrogen receptor [Y537S] 3.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263674&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232334 377002577 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500894 Oc1ccc2c(CCCC(c3ccc4[nH]ccc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 263675 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1H- indol-5-yl)- 8,9-dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 12 Estrogen receptor [Y537S] 10.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263675&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232954 377002578 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500897 Cc1cc(ccc1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33ClFNO2/c1-21-18-24(8-13-30(21)32)28-5-2-4-23-19-25(35)9-12-29(23)31(28)22-6-10-26(11-7-22)36-27-14-17-34(20-27)16-3-15-33/h6-13,18-19,27,35H,2-5,14-17,20H2,1H3/t27-/m0/s1 QBXYRIKCNHXXCH-MHZLTWQESA-N 263676 6-(4- chloro-3- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 13 Estrogen receptor [Y537S] 11.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263676&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232380 377002579 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500900 Oc1ccc2c(CCCC(c3ccncc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H30F2N2O2/c30-13-2-15-33-16-12-24(19-33)35-23-8-5-20(6-9-23)29-25-10-7-22(34)17-21(25)3-1-4-27(29)26-11-14-32-18-28(26)31/h5-11,14,17-18,24,34H,1-4,12-13,15-16,19H2/t24-/m0/s1 COHGCHWMGJSXFO-DEOSSOPVSA-N 263677 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- fluoro-4- pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 14 Estrogen receptor [Y537S] 7.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263677&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232804 377002580 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500903 Oc1ccc2c(CCCC(c3ccc(Cl)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30ClF2NO2/c31-22-7-11-27(29(33)18-22)28-4-1-3-21-17-23(35)8-12-26(21)30(28)20-5-9-24(10-6-20)36-25-13-16-34(19-25)15-2-14-32/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 SBYBTXOHVSSANB-VWLOTQADSA-N 263678 6-(4- chloro-2- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 15 Estrogen receptor [Y537S] 24.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263678&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232404 377002581 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500906 Oc1ccc2c(CCCC(c3ccc(Cl)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30ClF2NO2/c31-28-12-7-22(18-29(28)33)26-4-1-3-21-17-23(35)8-11-27(21)30(26)20-5-9-24(10-6-20)36-25-13-16-34(19-25)15-2-14-32/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 WXHBXFHVIYKALF-VWLOTQADSA-N 263679 6-(4- chloro-3- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 16 Estrogen receptor [Y537S] 63.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263679&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232405 377002582 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500909 Cc1cc(F)ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO2/c1-21-18-24(33)8-12-28(21)30-5-2-4-23-19-25(35)9-13-29(23)31(30)22-6-10-26(11-7-22)36-27-14-17-34(20-27)16-3-15-32/h6-13,18-19,27,35H,2-5,14-17,20H2,1H3/t27-/m0/s1 NDXYOBSDOYJMJI-MHZLTWQESA-N 263680 6-(4-fluoro- 2-methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 17 Estrogen receptor [Y537S] 15.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263680&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232373 377002583 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500912 Oc1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30Cl2FNO2/c31-22-7-11-27(29(32)18-22)28-4-1-3-21-17-23(35)8-12-26(21)30(28)20-5-9-24(10-6-20)36-25-13-16-34(19-25)15-2-14-33/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 QXPXETJODPRMBJ-VWLOTQADSA-N 263681 6-(2,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 18 Estrogen receptor [Y537S] 21.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263681&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232754 377002584 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500915 Oc1ccc2c(CCCC(c3ccc4cc[nH]c4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 263682 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1H- indol-6-yl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 19 Estrogen receptor [Y537S] 26.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263682&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233388 377002585 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500918 Oc1ccc2c(CCCC(c3cccc4[nH]ccc34)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 263683 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1H- indol-4-yl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6- indolin-5- yl-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 20 Estrogen receptor [Y537S] 9.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263683&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232353 377002586 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500921 Oc1ccc2c(CCCC(c3ccc4NCCc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H35FN2O2/c33-15-2-17-35-18-14-28(21-35)37-27-9-5-22(6-10-27)32-29(24-7-12-31-25(19-24)13-16-34-31)4-1-3-23-20-26(36)8-11-30(23)32/h5-12,19-20,28,34,36H,1-4,13-18,21H2/t28-/m0/s1 BEMOLRLWONFMRO-NDEPHWFRSA-N 263684 US9714221, Example 21 Estrogen receptor [Y537S] 26.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263684&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232355 377002587 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500924 Oc1ccc2c(CCCC(c3cnc4[nH]ccc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 263685 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1H- pyrrolo[2,3- b]pyridin- 5-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 22 Estrogen receptor [Y537S] 26.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263685&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232323 377002588 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500927 Cc1ccc(c(Cl)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33ClFNO2/c1-21-6-12-28(30(32)18-21)29-5-2-4-23-19-24(35)9-13-27(23)31(29)22-7-10-25(11-8-22)36-26-14-17-34(20-26)16-3-15-33/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 MZMFDHTWXWEMGY-SANMLTNESA-N 263686 6-(2- chloro-4- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 23 Estrogen receptor [Y537S] 4.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263686&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232335 377002589 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500930 CC(C)(C)OC(=O)N1CCC(=CC1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C34H43FN2O4/c1-34(2,3)41-33(39)37-20-14-24(15-21-37)30-7-4-6-26-22-27(38)10-13-31(26)32(30)25-8-11-28(12-9-25)40-29-16-19-36(23-29)18-5-17-35/h8-14,22,29,38H,4-7,15-21,23H2,1-3H3/t29-/m0/s1 FOGXJJRSDJOQPP-LJAQVGFWSA-N 263687 US9714221, Example 24::tert-butyl 4-[5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]-3,6- dihydro- 2H- pyridine-1- carboxylate5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1- methyl- 3,6- dihydro- 2H-pyridin- 4-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6- (1,2,3,6- tetrahydro pyridin-4- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol Estrogen receptor [Y537S] 475 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263687&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232847 377002590 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500933 CN1CCC(=CC1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H37FN2O2/c1-32-17-12-22(13-18-32)28-5-2-4-24-20-25(34)8-11-29(24)30(28)23-6-9-26(10-7-23)35-27-14-19-33(21-27)16-3-15-31/h6-12,20,27,34H,2-5,13-19,21H2,1H3/t27-/m0/s1 MJQOOLSCJLQSDB-MHZLTWQESA-N 263688 US9714221, Example 25 Estrogen receptor [Y537S] 726 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263688&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233175 377002591 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500936 Oc1ccc2c(CCCC(C3=CCNCC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H35FN2O2/c30-14-2-17-32-18-13-26(20-32)34-25-8-5-22(6-9-25)29-27(21-11-15-31-16-12-21)4-1-3-23-19-24(33)7-10-28(23)29/h5-11,19,26,31,33H,1-4,12-18,20H2/t26-/m0/s1 MMISJPDPZKGOJW-SANMLTNESA-N 263689 US9714221, Example 26 Estrogen receptor [Y537S] 341 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263689&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233150 377002592 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500939 CCOc1ccc(c(C)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H38FNO3/c1-3-37-28-13-15-30(23(2)20-28)32-7-4-6-25-21-26(36)10-14-31(25)33(32)24-8-11-27(12-9-24)38-29-16-19-35(22-29)18-5-17-34/h8-15,20-21,29,36H,3-7,16-19,22H2,1-2H3/t29-/m0/s1 USUBOVRSGQTBDN-LJAQVGFWSA-N 263690 6-(4- ethoxy-2- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 27 Estrogen receptor [Y537S] 6.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263690&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233378 377002593 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500942 Oc1ccc2c(CCCC(c3ccc4occc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H32FNO3/c33-15-2-16-34-17-13-28(21-34)37-27-9-5-22(6-10-27)32-29(24-7-12-31-25(19-24)14-18-36-31)4-1-3-23-20-26(35)8-11-30(23)32/h5-12,14,18-20,28,35H,1-4,13,15-17,21H2/t28-/m0/s1 RZAURWDDKRVTEZ-NDEPHWFRSA-N 263691 6- (benzofuran- 5-yl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(2-fluoro- 4- methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 28 Estrogen receptor [Y537S] 4.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263691&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233173 377002594 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500945 COc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO3/c1-36-25-11-13-28(30(33)19-25)29-5-2-4-22-18-23(35)8-12-27(22)31(29)21-6-9-24(10-7-21)37-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 OJORZZZISIXVNW-SANMLTNESA-N 263692 US9714221, Example 29 Estrogen receptor [Y537S] 2.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263692&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232340 377002595 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500948 Cc1cc2cc(ccc2[nH]1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 263693 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- methyl-1H- indol-5-yl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 30 Estrogen receptor [Y537S] 9.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263693&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233148 377002596 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500951 Cc1cccc(c1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H36FNO2/c1-22-6-3-8-29(23(22)2)31-9-4-7-25-20-26(35)12-15-30(25)32(31)24-10-13-27(14-11-24)36-28-16-19-34(21-28)18-5-17-33/h3,6,8,10-15,20,28,35H,4-5,7,9,16-19,21H2,1-2H3/t28-/m0/s1 GTNPDWWRBANDGJ-NDEPHWFRSA-N 263694 6-(2,3- dimethyl- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy_ phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 31 Estrogen receptor [Y537S] 12.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263694&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233375 377002597 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500954 Cc1cc(Cl)ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33ClFNO2/c1-21-18-24(32)8-12-28(21)30-5-2-4-23-19-25(35)9-13-29(23)31(30)22-6-10-26(11-7-22)36-27-14-17-34(20-27)16-3-15-33/h6-13,18-19,27,35H,2-5,14-17,20H2,1H3/t27-/m0/s1 BSZSJGOTXDHKAY-MHZLTWQESA-N 263695 6-(4- chloro-2- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 32 Estrogen receptor [Y537S] 24.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263695&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233187 377002598 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500957 Cc1c(F)cccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO2/c1-21-27(6-3-8-30(21)33)29-7-2-5-23-19-24(35)11-14-28(23)31(29)22-9-12-25(13-10-22)36-26-15-18-34(20-26)17-4-16-32/h3,6,8-14,19,26,35H,2,4-5,7,15-18,20H2,1H3/t26-/m0/s1 RDWHIVISWJHCIF-SANMLTNESA-N 263696 6-(3-fluoro- 2-methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 33 Estrogen receptor [Y537S] 24.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263696&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232396 377002599 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500960 CCOc1ccc(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H35FN2O3/c1-2-36-30-14-9-24(20-33-30)28-6-3-5-23-19-25(35)10-13-29(23)31(28)22-7-11-26(12-8-22)37-27-15-18-34(21-27)17-4-16-32/h7-14,19-20,27,35H,2-6,15-18,21H2,1H3/t27-/m0/s1 YSTGXOMKPNVARP-MHZLTWQESA-N 263697 6-(6- ethoxy-3- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 34 Estrogen receptor [Y537S] 11.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263697&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232351 377002600 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500963 Cc1ccc(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO2/c1-21-6-7-24(19-30(21)33)28-5-2-4-23-18-25(35)10-13-29(23)31(28)22-8-11-26(12-9-22)36-27-14-17-34(20-27)16-3-15-32/h6-13,18-19,27,35H,2-5,14-17,20H2,1H3/t27-/m0/s1 YIRHCKAEEVQWJY-MHZLTWQESA-N 263698 6-(3-fluoro- 4-methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 35 Estrogen receptor [Y537S] 134 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263698&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232834 377002601 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500966 Cc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO2/c1-21-6-12-28(30(33)18-21)29-5-2-4-23-19-24(35)9-13-27(23)31(29)22-7-10-25(11-8-22)36-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 JFBNOOJPWYHFES-SANMLTNESA-N 263672 US9714221, Example 36::US9714221, Example 9 Estrogen receptor [Y537S] 50.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263672&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232796 377002575 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500969 Cc1ccc(cc1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33ClFNO2/c1-21-6-7-24(19-30(21)32)28-5-2-4-23-18-25(35)10-13-29(23)31(28)22-8-11-26(12-9-22)36-27-14-17-34(20-27)16-3-15-33/h6-13,18-19,27,35H,2-5,14-17,20H2,1H3/t27-/m0/s1 DNIANVYLRTYLPI-MHZLTWQESA-N 263700 6-(3- chloro-4- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 37 Estrogen receptor [Y537S] 241 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263700&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232371 377002602 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500972 Oc1ccc2c(CCCC(c3ccc(Cl)c(Cl)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30Cl2FNO2/c31-28-12-7-22(18-29(28)32)26-4-1-3-21-17-23(35)8-11-27(21)30(26)20-5-9-24(10-6-20)36-25-13-16-34(19-25)15-2-14-33/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1 HTUALDBVBGCMRV-VWLOTQADSA-N 263701 6-(3,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(3- chloro-2- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 38 Estrogen receptor [Y537S] 651 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263701&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232318 377002603 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500975 Oc1ccc2c(CCCC(c3cccc(Cl)c3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30ClF2NO2/c31-28-7-2-6-27(30(28)33)26-5-1-4-21-18-22(35)10-13-25(21)29(26)20-8-11-23(12-9-20)36-24-14-17-34(19-24)16-3-15-32/h2,6-13,18,24,35H,1,3-5,14-17,19H2/t24-/m0/s1 NKOXERWKWUIWDO-DEOSSOPVSA-N 263702 6-(3-chloro-2-fluoro-phenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulen-2-ol::US9714221, Example 39 Estrogen receptor [Y537S] 53.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263702&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232807 377002604 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500978 COc1cc(F)ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO3/c1-36-30-19-23(33)8-12-28(30)29-5-2-4-22-18-24(35)9-13-27(22)31(29)21-6-10-25(11-7-21)37-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 KEZQAOPYJUSQSS-SANMLTNESA-N 263703 6-(4-fluoro- 2-methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 40 Estrogen receptor [Y537S] 224 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263703&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232377 377002605 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500981 COc1c(F)cccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO3/c1-36-31-28(7-3-8-29(31)33)27-6-2-5-22-19-23(35)11-14-26(22)30(27)21-9-12-24(13-10-21)37-25-15-18-34(20-25)17-4-16-32/h3,7-14,19,25,35H,2,4-6,15-18,20H2,1H3/t25-/m0/s1 RYTOZMQIFQUHDP-VWLOTQADSA-N 263704 6-(3-fluoro- 2-methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 41 Estrogen receptor [Y537S] 133 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263704&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232789 377002606 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500984 CCOc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H35F2NO3/c1-2-37-26-12-14-29(31(34)20-26)30-6-3-5-23-19-24(36)9-13-28(23)32(30)22-7-10-25(11-8-22)38-27-15-18-35(21-27)17-4-16-33/h7-14,19-20,27,36H,2-6,15-18,21H2,1H3/t27-/m0/s1 CIJQRNZQUZGFEI-MHZLTWQESA-N 263705 6-(4- ethoxy-2- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 42 Estrogen receptor [Y537S] 33.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263705&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232934 377002607 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500987 CCOc1ccc(c(Cl)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H35ClFNO3/c1-2-37-26-12-14-29(31(33)20-26)30-6-3-5-23-19-24(36)9-13-28(23)32(30)22-7-10-25(11-8-22)38-27-15-18-35(21-27)17-4-16-34/h7-14,19-20,27,36H,2-6,15-18,21H2,1H3/t27-/m0/s1 FNWAKSQJQUEYND-MHZLTWQESA-N 263706 6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 43 Estrogen receptor [Y537S] 11.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263706&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232317 377002608 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500990 COc1ccc(c(C)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H36FNO3/c1-22-19-27(36-2)12-14-29(22)31-6-3-5-24-20-25(35)9-13-30(24)32(31)23-7-10-26(11-8-23)37-28-15-18-34(21-28)17-4-16-33/h7-14,19-20,28,35H,3-6,15-18,21H2,1-2H3/t28-/m0/s1 JDJNAPSFYSTLSF-NDEPHWFRSA-N 263707 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- methoxy- 2-methyl- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol1-fluoro-6- (2-fluoro-4- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 44 Estrogen receptor [Y537S] 12.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263707&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232322 377002609 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500993 Cc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1 InChI=1S/C31H32F3NO2/c1-20-6-11-24(28(33)18-20)25-4-2-5-27-26(12-13-29(36)31(27)34)30(25)21-7-9-22(10-8-21)37-23-14-17-35(19-23)16-3-15-32/h6-13,18,23,36H,2-5,14-17,19H2,1H3/t23-/m0/s1 GUJPHVNSSYDRIT-QHCPKHFHSA-N 263708 US9714221, Example 45 Estrogen receptor [Y537S] 23.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263708&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232921 377002610 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500996 CCOc1ccc(c(C)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1 InChI=1S/C33H37F2NO3/c1-3-38-25-12-13-27(22(2)20-25)28-6-4-7-30-29(14-15-31(37)33(30)35)32(28)23-8-10-24(11-9-23)39-26-16-19-36(21-26)18-5-17-34/h8-15,20,26,37H,3-7,16-19,21H2,1-2H3/t26-/m0/s1 CXHAXDNLQJNAAM-SANMLTNESA-N 263709 6-(4- ethoxy-2- methyl- phenyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 46 Estrogen receptor [Y537S] 16.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263709&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232772 377002611 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 500999 Oc1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C30H29Cl2F2NO2/c31-20-7-10-23(27(32)17-20)24-3-1-4-26-25(11-12-28(36)30(26)34)29(24)19-5-8-21(9-6-19)37-22-13-16-35(18-22)15-2-14-33/h5-12,17,22,36H,1-4,13-16,18H2/t22-/m0/s1 OGLHZCIYFPJVBD-QFIPXVFZSA-N 263710 6-(2,4- dichloro- phenyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(2-fluoro- 4-methyl- phenyl)-5- [4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 47 Estrogen receptor [Y537S] 23.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263710&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232966 377002612 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501002 Cc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(cc2CCC1)C(O)=O InChI=1S/C32H33F2NO3/c1-21-6-12-28(30(34)18-21)29-5-2-4-23-19-24(32(36)37)9-13-27(23)31(29)22-7-10-25(11-8-22)38-26-14-17-35(20-26)16-3-15-33/h6-13,18-19,26H,2-5,14-17,20H2,1H3,(H,36,37)/t26-/m0/s1 RFLWHTIWYIBBNC-SANMLTNESA-N 263711 6-(2-fluoro-4-methyl-phenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid::US9714221, Example 48 Estrogen receptor [Y537S] 549 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263711&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232399 377002613 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501005 Oc1ccc2c(CCCC(c3ccc4OCCOc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H34FNO4/c33-14-2-15-34-16-13-27(21-34)38-26-9-5-22(6-10-26)32-28(4-1-3-23-19-25(35)8-11-29(23)32)24-7-12-30-31(20-24)37-18-17-36-30/h5-12,19-20,27,35H,1-4,13-18,21H2/t27-/m0/s1 ADISAXSMAYSLEN-MHZLTWQESA-N 263712 6-(2,3- dihydro- 1,4- benzodioxin-6-yl)-5- [4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 49 Estrogen receptor [Y537S] 6.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263712&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233189 377002614 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501008 COc1cc(ccc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO3/c1-36-30-19-23(8-13-29(30)33)27-5-2-4-22-18-24(35)9-12-28(22)31(27)21-6-10-25(11-7-21)37-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 TYJXXJBRQUXAPS-SANMLTNESA-N 263713 6-(4-fluoro- 3-methoxy- phenyl)-5- [4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(2,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 50 Estrogen receptor [Y537S] 113 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263713&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232369 377002615 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501011 OC(=O)c1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30Cl2FNO3/c32-23-8-12-27(29(33)18-23)28-4-1-3-21-17-22(31(36)37)7-11-26(21)30(28)20-5-9-24(10-6-20)38-25-13-16-35(19-25)15-2-14-34/h5-12,17-18,25H,1-4,13-16,19H2,(H,36,37)/t25-/m0/s1 KISZAGQTIXIVAR-VWLOTQADSA-N 263716 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid::US9714221, Example 51 Estrogen receptor [Y537S] 221 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263716&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search L5B 6SBO 130232326 377002618 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501014 CCOc1ccc(c(F)c1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34F3NO3/c1-2-38-29-14-13-28(31(34)32(29)35)27-6-3-5-22-19-23(37)9-12-26(22)30(27)21-7-10-24(11-8-21)39-25-15-18-36(20-25)17-4-16-33/h7-14,19,25,37H,2-6,15-18,20H2,1H3/t25-/m0/s1 DTTAWYZPFSILKH-VWLOTQADSA-N 263717 6-(4- ethoxy- 2,3- difluoro- phenyl)-5- [4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 52 Estrogen receptor [Y537S] 29.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263717&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232889 377002619 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501017 OC(=O)c1ccc2c(CCCC(c3ccc(Cl)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30ClF2NO3/c32-28-12-8-22(18-29(28)34)26-4-1-3-21-17-23(31(36)37)7-11-27(21)30(26)20-5-9-24(10-6-20)38-25-13-16-35(19-25)15-2-14-33/h5-12,17-18,25H,1-4,13-16,19H2,(H,36,37)/t25-/m0/s1 RNNLCWBLRAXREA-VWLOTQADSA-N 263718 6-(4- chloro-3- fluoro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 53 Estrogen receptor [Y537S] 2857 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263718&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232372 377002620 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501020 Oc1ccc2c(CCCC(c3ccc4ocnc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31FN2O3/c32-14-2-15-34-16-13-26(19-34)37-25-9-5-21(6-10-25)31-27(23-7-12-30-29(18-23)33-20-36-30)4-1-3-22-17-24(35)8-11-28(22)31/h5-12,17-18,20,26,35H,1-4,13-16,19H2/t26-/m0/s1 BWROCZGXXLTLRL-SANMLTNESA-N 263719 6-(1,3- benzoxazol- 5-yl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 54 Estrogen receptor [Y537S] 5.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263719&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232856 377002621 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501023 OC(=O)c1ccc2c(CCCC(c3ccc(O)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H32FNO4/c32-16-2-17-33-18-15-27(20-33)37-26-12-7-22(8-13-26)30-28(21-5-10-25(34)11-6-21)4-1-3-23-19-24(31(35)36)9-14-29(23)30/h5-14,19,27,34H,1-4,15-18,20H2,(H,35,36)/t27-/m0/s1 QXBKQFVPLCSNHX-MHZLTWQESA-N 263720 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- hydroxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid::US9714221, Example 55 Estrogen receptor [Y537S] 338 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263720&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232330 377002622 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501026 CC(C)c1ccccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H38FNO2/c1-23(2)29-8-3-4-9-31(29)32-10-5-7-25-21-26(36)13-16-30(25)33(32)24-11-14-27(15-12-24)37-28-17-20-35(22-28)19-6-18-34/h3-4,8-9,11-16,21,23,28,36H,5-7,10,17-20,22H2,1-2H3/t28-/m0/s1 VYYSOYJJBCQWRS-NDEPHWFRSA-N 263721 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- isopropyl- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 56 Estrogen receptor [Y537S] 204 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263721&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232768 377002623 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501029 Cc1ccccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H34FNO2/c1-22-6-2-3-8-28(22)30-9-4-7-24-20-25(34)12-15-29(24)31(30)23-10-13-26(14-11-23)35-27-16-19-33(21-27)18-5-17-32/h2-3,6,8,10-15,20,27,34H,4-5,7,9,16-19,21H2,1H3/t27-/m0/s1 QOBMATRRZKMQMJ-MHZLTWQESA-N 263722 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(o- tolyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 57 Estrogen receptor [Y537S] 39.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263722&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233389 377002624 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501032 Oc1ccc2c(CCCC(c3ccccc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H31ClFNO2/c31-29-8-2-1-6-27(29)28-7-3-5-22-19-23(34)11-14-26(22)30(28)21-9-12-24(13-10-21)35-25-15-18-33(20-25)17-4-16-32/h1-2,6,8-14,19,25,34H,3-5,7,15-18,20H2/t25-/m0/s1 KLUZCXSKHCEPRH-VWLOTQADSA-N 263723 6-(2- chlorophenyl)- 5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 58 Estrogen receptor [Y537S] 24.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263723&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233396 377002625 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501035 COc1ccc(c(c1)C#N)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H33FN2O3/c1-37-27-11-13-29(24(19-27)20-34)31-5-2-4-23-18-25(36)8-12-30(23)32(31)22-6-9-26(10-7-22)38-28-14-17-35(21-28)16-3-15-33/h6-13,18-19,28,36H,2-5,14-17,21H2,1H3/t28-/m0/s1 UDRYDJHIFCMIIJ-NDEPHWFRSA-N 263724 2-[5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy-8,9- dihydro- 7H- benzo[7]- annulen-6- yl]-5- methoxy- benzonitrile::US9714221, Example 59 Estrogen receptor [Y537S] 34.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263724&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233185 377002626 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501038 Oc1ccc2c(CCCC(c3ccccc3C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31F4NO2/c32-16-4-17-36-18-15-25(20-36)38-24-12-9-21(10-13-24)30-26-14-11-23(37)19-22(26)5-3-7-28(30)27-6-1-2-8-29(27)31(33,34)35/h1-2,6,8-14,19,25,37H,3-5,7,15-18,20H2/t25-/m0/s1 QCIUMHGLPRVZQO-VWLOTQADSA-N 263725 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[2- (trifluoro- methyl)phenyl]- 8,9-dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 60 Estrogen receptor [Y537S] 39.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263725&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232821 377002627 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501041 Oc1ccc2c(CCCC(c3ccc(F)cc3C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30F5NO2/c32-14-2-15-37-16-13-25(19-37)39-24-9-5-20(6-10-24)30-26-12-8-23(38)17-21(26)3-1-4-28(30)27-11-7-22(33)18-29(27)31(34,35)36/h5-12,17-18,25,38H,1-4,13-16,19H2/t25-/m0/s1 XXBLELZVJUOVRC-VWLOTQADSA-N 263726 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- fluoro-2- (trifluoro- methyl)phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 61 Estrogen receptor [Y537S] 99.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263726&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233210 377002628 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501044 CCOc1cc(F)c(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34F3NO3/c1-2-38-31-19-29(34)28(18-30(31)35)27-6-3-5-22-17-23(37)9-12-26(22)32(27)21-7-10-24(11-8-21)39-25-13-16-36(20-25)15-4-14-33/h7-12,17-19,25,37H,2-6,13-16,20H2,1H3/t25-/m0/s1 IKUDYDRJIQDYKH-VWLOTQADSA-N 263728 6-(4-ethoxy- 2,5- difluoro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- methoxy- 2-methyl- phenyl)- 8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid hydrochloride::US9714221, Example 62 Estrogen receptor [Y537S] 178 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263728&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232805 377002630 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501047 COc1ccc(c(C)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(cc2CCC1)C(O)=O InChI=1S/C33H36FNO4/c1-22-19-27(38-2)12-14-29(22)31-6-3-5-24-20-25(33(36)37)9-13-30(24)32(31)23-7-10-26(11-8-23)39-28-15-18-35(21-28)17-4-16-34/h7-14,19-20,28H,3-6,15-18,21H2,1-2H3,(H,36,37)/t28-/m0/s1 SRRUADFMGHFSMX-NDEPHWFRSA-N 263729 5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-6-(4-methoxy-2-methyl-phenyl)-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid::US9714221, Example 63 Estrogen receptor [Y537S] 72.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263729&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232398 377002631 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501050 COc1ccc(c(OC)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H36FNO4/c1-36-26-12-14-29(31(20-26)37-2)30-6-3-5-23-19-24(35)9-13-28(23)32(30)22-7-10-25(11-8-22)38-27-15-18-34(21-27)17-4-16-33/h7-14,19-20,27,35H,3-6,15-18,21H2,1-2H3/t27-/m0/s1 WNWAMUHZQZGPSQ-MHZLTWQESA-N 263730 6-(2,4- dimethoxy phenyl)-5- [4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 64 Estrogen receptor [Y537S] 88.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263730&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233355 377002632 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501053 COc1ccc(c(c1)C(F)(F)F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H33F4NO3/c1-39-25-11-13-28(30(19-25)32(34,35)36)29-5-2-4-22-18-23(38)8-12-27(22)31(29)21-6-9-24(10-7-21)40-26-14-17-37(20-26)16-3-15-33/h6-13,18-19,26,38H,2-5,14-17,20H2,1H3/t26-/m0/s1 SATIEICECCYFAX-SANMLTNESA-N 263731 5-[4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- methoxy-2- (trifluoro- methyl)phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 65 Estrogen receptor [Y537S] 25.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263731&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232858 377002633 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501056 Oc1ccc2c(CCCC(c3ccc(OC(F)F)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31F4NO3/c32-14-2-15-36-16-13-25(19-36)38-24-9-5-20(6-10-24)30-26(4-1-3-21-17-23(37)8-11-27(21)30)22-7-12-29(28(33)18-22)39-31(34)35/h5-12,17-18,25,31,37H,1-4,13-16,19H2/t25-/m0/s1 PBIPOWQYIZIDJG-VWLOTQADSA-N 263732 6-[4- (difluoro- methoxy)-3- fluoro- phenyl]-5- [4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 66 Estrogen receptor [Y537S] 127 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263732&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232345 377002634 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501059 Cc1cc(ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1)C(F)(F)F InChI=1S/C32H33F4NO2/c1-21-18-24(32(34,35)36)8-12-28(21)30-5-2-4-23-19-25(38)9-13-29(23)31(30)22-6-10-26(11-7-22)39-27-14-17-37(20-27)16-3-15-33/h6-13,18-19,27,38H,2-5,14-17,20H2,1H3/t27-/m0/s1 ALLVKMHYGHXFIH-MHZLTWQESA-N 263733 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[2- methyl-4- (trifluoro- methyl)phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 67 Estrogen receptor [Y537S] 85.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263733&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232319 377002635 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501062 Oc1ccc2c(CCCC(c3ccc(nc3)C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H30F4N2O2/c31-14-2-15-36-16-13-25(19-36)38-24-9-5-20(6-10-24)29-26(22-7-12-28(35-18-22)30(32,33)34)4-1-3-21-17-23(37)8-11-27(21)29/h5-12,17-18,25,37H,1-4,13-16,19H2/t25-/m0/s1 GXXWEURCLBFYKN-VWLOTQADSA-N 263734 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[6- (trifluoro- methyl)-3- pyridyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 68 Estrogen receptor [Y537S] 109 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263734&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232378 377002636 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501065 Oc1ccc2c(CCCC(c3ccc(OC(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H32F3NO3/c32-16-2-17-35-18-15-27(20-35)37-25-12-7-22(8-13-25)30-28(21-5-10-26(11-6-21)38-31(33)34)4-1-3-23-19-24(36)9-14-29(23)30/h5-14,19,27,31,36H,1-4,15-18,20H2/t27-/m0/s1 OFOWDWJOQQVPES-MHZLTWQESA-N 263735 6-[4- (difluoro- methoxy)phenyl]- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(2,2- dimethyl- indolin-5-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 69 Estrogen receptor [Y537S] 90.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263735&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233195 377002637 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501068 CC(=O)N1c2ccc(cc2CC1(C)C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C36H41FN2O3/c1-24(40)39-34-15-10-27(20-28(34)22-36(39,2)3)32-7-4-6-26-21-29(41)11-14-33(26)35(32)25-8-12-30(13-9-25)42-31-16-19-38(23-31)18-5-17-37/h8-15,20-21,31,41H,4-7,16-19,22-23H2,1-3H3/t31-/m0/s1 YEZOGKJKJHMACS-HKBQPEDESA-N 263736 US9714221, Example 70 Estrogen receptor [Y537S] 22.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263736&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232383 377002638 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501071 CCOc1ccc(c(F)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H34F2N2O3/c1-2-37-29-14-13-28(31(33)34-29)27-6-3-5-22-19-23(36)9-12-26(22)30(27)21-7-10-24(11-8-21)38-25-15-18-35(20-25)17-4-16-32/h7-14,19,25,36H,2-6,15-18,20H2,1H3/t25-/m0/s1 NHZRXBWSUJECAF-VWLOTQADSA-N 263737 6-(6- ethoxy-2- fluoro-3- pyridyl)-5- [4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 71 Estrogen receptor [Y537S] 18.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263737&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233192 377002639 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501074 CC(C)(C)c1ccc(cc1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C34H40FNO2/c1-34(2,3)27-12-8-24(9-13-27)31-7-4-6-26-22-28(37)14-17-32(26)33(31)25-10-15-29(16-11-25)38-30-18-21-36(23-30)20-5-19-35/h8-17,22,30,37H,4-7,18-21,23H2,1-3H3/t30-/m0/s1 JNKDCALYMAIMGY-PMERELPUSA-N 263738 6-(4-tert- butyl- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6- (1,2,3,4- tetrahydro quinolin-6- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 72 Estrogen receptor [Y537S] 498 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263738&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232336 377002640 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501077 Oc1ccc2c(CCCC(c3ccc4NCCCc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C33H37FN2O2/c34-16-3-18-36-19-15-29(22-36)38-28-11-7-23(8-12-28)33-30(6-1-4-24-21-27(37)10-13-31(24)33)25-9-14-32-26(20-25)5-2-17-35-32/h7-14,20-21,29,35,37H,1-6,15-19,22H2/t29-/m0/s1 YEUFVTYXYDSXRQ-LJAQVGFWSA-N 263739 5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-6-(1,2,3,4-tetrahydroquinolin-6-yl)-8,9-dihydro-7H-benzo[7]annulen-2-ol::US9714221, Example 73 Estrogen receptor [Y537S] 40.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263739&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232760 377002641 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501080 CCOc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H36FNO3/c1-2-36-28-8-3-6-25(21-28)30-9-4-7-24-20-26(35)12-15-31(24)32(30)23-10-13-27(14-11-23)37-29-16-19-34(22-29)18-5-17-33/h3,6,8,10-15,20-21,29,35H,2,4-5,7,9,16-19,22H2,1H3/t29-/m0/s1 ZOVVWRPCDDVIKC-LJAQVGFWSA-N 263740 6-(3-ethoxy- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- methoxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 74 Estrogen receptor [Y537S] 26.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263740&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233151 377002642 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501083 Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31F4NO3/c32-16-2-17-36-18-15-27(20-36)38-25-10-7-22(8-11-25)30-28(4-1-3-23-19-24(37)9-14-29(23)30)21-5-12-26(13-6-21)39-31(33,34)35/h5-14,19,27,37H,1-4,15-18,20H2/t27-/m0/s1 CUVIEOMIPZIETH-MHZLTWQESA-N 263741 US9714221, Example 75 Estrogen receptor [Y537S] 679 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263741&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232769 377002643 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501086 COc1ccc(cc1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H34FNO3/c1-35-26-11-6-22(7-12-26)29-5-2-4-24-20-25(34)10-15-30(24)31(29)23-8-13-27(14-9-23)36-28-16-19-33(21-28)18-3-17-32/h6-15,20,28,34H,2-5,16-19,21H2,1H3/t28-/m0/s1 SORSKAIVHYYAIZ-NDEPHWFRSA-N 263742 US9714221, Example 76 Estrogen receptor [Y537S] 23.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263742&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232922 377002644 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501089 COc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H34FNO3/c1-35-27-7-2-5-24(20-27)29-8-3-6-23-19-25(34)11-14-30(23)31(29)22-9-12-26(13-10-22)36-28-15-18-33(21-28)17-4-16-32/h2,5,7,9-14,19-20,28,34H,3-4,6,8,15-18,21H2,1H3/t28-/m0/s1 SYVAZHLFGNMHAJ-NDEPHWFRSA-N 263743 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- methoxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 77 Estrogen receptor [Y537S] 13.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263743&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233172 377002645 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501092 Oc1ccc2c(CCCC(c3ccc(cc3)C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31F4NO2/c32-16-2-17-36-18-15-27(20-36)38-26-12-7-22(8-13-26)30-28(21-5-9-24(10-6-21)31(33,34)35)4-1-3-23-19-25(37)11-14-29(23)30/h5-14,19,27,37H,1-4,15-18,20H2/t27-/m0/s1 BDCSNBMXCOWDTI-MHZLTWQESA-N 263744 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methyl)- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 78 Estrogen receptor [Y537S] 185 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263744&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232384 377002646 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501095 Oc1ccc2c(CCCC(c3ccc(OC(F)F)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H30F5NO3/c32-14-2-15-37-16-13-22(18-37)39-21-8-5-19(6-9-21)29-23(20-7-12-28(26(33)17-20)40-31(35)36)3-1-4-25-24(29)10-11-27(38)30(25)34/h5-12,17,22,31,38H,1-4,13-16,18H2/t22-/m0/s1 JATWKYWAHZFIFG-QFIPXVFZSA-N 263745 6-[4- (difluoro- methoxy)-3- fluoro- phenyl]-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 79 Estrogen receptor [Y537S] 113 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263745&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232342 377002647 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501098 CCOc1ncc(cc1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H34ClFN2O3/c1-2-37-31-29(32)18-23(19-34-31)27-6-3-5-22-17-24(36)9-12-28(22)30(27)21-7-10-25(11-8-21)38-26-13-16-35(20-26)15-4-14-33/h7-12,17-19,26,36H,2-6,13-16,20H2,1H3/t26-/m0/s1 CTCXTSBOVQBYSN-SANMLTNESA-N 263746 6-(5- chloro-6- ethoxy-3- pyridyl)-5- [4-[(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 80 Estrogen receptor [Y537S] 203 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263746&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232339 377002648 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501101 CCc1ccccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H36FNO2/c1-2-23-7-3-4-9-29(23)31-10-5-8-25-21-26(35)13-16-30(25)32(31)24-11-14-27(15-12-24)36-28-17-20-34(22-28)19-6-18-33/h3-4,7,9,11-16,21,28,35H,2,5-6,8,10,17-20,22H2,1H3/t28-/m0/s1 FUUZCCQZJUABHI-NDEPHWFRSA-N 263747 6-(2- ethylphenyl)- 5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(6- ethoxy-2- fluoro-3- pyridyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 81 Estrogen receptor [Y537S] 93.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263747&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232806 377002649 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501104 CCOc1ccc(c(F)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1 InChI=1S/C31H33F3N2O3/c1-2-38-28-14-12-26(31(34)35-28)23-5-3-6-25-24(11-13-27(37)30(25)33)29(23)20-7-9-21(10-8-20)39-22-15-18-36(19-22)17-4-16-32/h7-14,22,37H,2-6,15-19H2,1H3/t22-/m0/s1 FBHVFHCHHWPPOJ-QFIPXVFZSA-N 263748 US9714221, Example 82 Estrogen receptor [Y537S] 16.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263748&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233359 377002650 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501107 COc1ncc(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C29H32FN3O3/c1-35-29-31-17-22(18-32-29)26-5-2-4-21-16-23(34)8-11-27(21)28(26)20-6-9-24(10-7-20)36-25-12-15-33(19-25)14-3-13-30/h6-11,16-18,25,34H,2-5,12-15,19H2,1H3/t25-/m0/s1 KIEBERXVFNDMRW-VWLOTQADSA-N 263749 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- methoxy- pyrimidin-5- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 83 Estrogen receptor [Y537S] 648 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263749&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232940 377002651 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501110 Oc1ccc2c(CCCC(c3cnc(nc3)C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H29F4N3O2/c30-12-2-13-36-14-11-24(18-36)38-23-8-5-19(6-9-23)27-25(21-16-34-28(35-17-21)29(31,32)33)4-1-3-20-15-22(37)7-10-26(20)27/h5-10,15-17,24,37H,1-4,11-14,18H2/t24-/m0/s1 ZIWQBWBRLWVJOS-DEOSSOPVSA-N 263750 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[2- (trifluoro- methyl)- pyrimidin-5-yl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 84 Estrogen receptor [Y537S] 964 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263750&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232795 377002652 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501113 Oc1ccc2c(CCCC(c3ccc(C#N)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30F2N2O2/c32-14-2-15-35-16-13-27(20-35)37-26-10-7-21(8-11-26)31-28(23-5-6-24(19-34)30(33)18-23)4-1-3-22-17-25(36)9-12-29(22)31/h5-12,17-18,27,36H,1-4,13-16,20H2/t27-/m0/s1 BBEQQPWXVBUVFK-MHZLTWQESA-N 263751 2-fluoro-4- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]benzo- nitrile::US9714221, Example 85 Estrogen receptor [Y537S] 735 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263751&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233403 377002653 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501116 Oc1ccc2c(CCCC(c3cncc(Cl)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H30ClFN2O2/c30-23-15-22(17-32-18-23)27-4-1-3-21-16-24(34)7-10-28(21)29(27)20-5-8-25(9-6-20)35-26-11-14-33(19-26)13-2-12-31/h5-10,15-18,26,34H,1-4,11-14,19H2/t26-/m0/s1 YMUKQGJNWAVWJQ-SANMLTNESA-N 263752 6-(5- chloro-3- pyridyl)-5- [4-[(3S)-1- (3-fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 86 Estrogen receptor [Y537S] 172 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263752&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232320 377002654 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501119 Oc1ccc2c(CCCC(c3ccc(OC(F)F)nc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H31F3N2O3/c31-14-2-15-35-16-13-25(19-35)37-24-9-5-20(6-10-24)29-26(22-7-12-28(34-18-22)38-30(32)33)4-1-3-21-17-23(36)8-11-27(21)29/h5-12,17-18,25,30,36H,1-4,13-16,19H2/t25-/m0/s1 YCAVWZKBLKAGGX-VWLOTQADSA-N 263753 6-[6- (difluoro- methoxy)-3- pyridyl]-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 87 Estrogen receptor [Y537S] 93.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263753&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232376 377002655 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501122 COc1cc(F)c(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H32F3NO3/c1-37-30-18-28(33)27(17-29(30)34)26-5-2-4-21-16-22(36)8-11-25(21)31(26)20-6-9-23(10-7-20)38-24-12-15-35(19-24)14-3-13-32/h6-11,16-18,24,36H,2-5,12-15,19H2,1H3/t24-/m0/s1 YTHVJHRXUZNAGJ-DEOSSOPVSA-N 263754 6-(2,5- difluoro-4- methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 88 Estrogen receptor [Y537S] 78.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263754&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232936 377002656 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501125 COc1ccc(c(Cl)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33ClFNO3/c1-36-25-11-13-28(30(32)19-25)29-5-2-4-22-18-23(35)8-12-27(22)31(29)21-6-9-24(10-7-21)37-26-14-17-34(20-26)16-3-15-33/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 WHKRBBJEAJGOED-SANMLTNESA-N 263755 6-(2- chloro-4- methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 89 Estrogen receptor [Y537S] 8.00 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263755&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232874 377002657 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501128 Oc1ccc2c(CCCC(c3cncc(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H30F2N2O2/c30-12-2-13-33-14-11-26(19-33)35-25-8-5-20(6-9-25)29-27(22-15-23(31)18-32-17-22)4-1-3-21-16-24(34)7-10-28(21)29/h5-10,15-18,26,34H,1-4,11-14,19H2/t26-/m0/s1 ZYJPUPRZZRMEOT-SANMLTNESA-N 263756 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(5- fluoro-3- pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 90 Estrogen receptor [Y537S] 190 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263756&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232877 377002658 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501131 COc1cc(C)c(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H35FN2O3/c1-21-17-30(36-2)33-19-29(21)28-6-3-5-23-18-24(35)9-12-27(23)31(28)22-7-10-25(11-8-22)37-26-13-16-34(20-26)15-4-14-32/h7-12,17-19,26,35H,3-6,13-16,20H2,1-2H3/t26-/m0/s1 BWFJONPPNWGTLW-SANMLTNESA-N 263757 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(6- methoxy- 4-methyl- 3-pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 91 Estrogen receptor [Y537S] 18.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263757&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232826 377002659 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501134 COc1cc(C)c(cc1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H38FNO3/c1-22-19-32(37-3)23(2)18-31(22)30-7-4-6-25-20-26(36)10-13-29(25)33(30)24-8-11-27(12-9-24)38-28-14-17-35(21-28)16-5-15-34/h8-13,18-20,28,36H,4-7,14-17,21H2,1-3H3/t28-/m0/s1 FZSAXXQMCCVPTC-NDEPHWFRSA-N 263758 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- methoxy- 2,5- dimthyl- phenyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 92 Estrogen receptor [Y537S] 504 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263758&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232381 377002660 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501281 Nc1ncc(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C28H31FN4O2/c29-12-2-13-33-14-11-24(18-33)35-23-8-5-19(6-9-23)27-25(21-16-31-28(30)32-17-21)4-1-3-20-15-22(34)7-10-26(20)27/h5-10,15-17,24,34H,1-4,11-14,18H2,(H2,30,31,32)/t24-/m0/s1 HUEKAJLVTQFDFO-DEOSSOPVSA-N 263808 6-(2- amino- pyrimidin-5- yl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 141 Estrogen receptor [Y537S] 436 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263808&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233190 377002710 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501284 Oc1ccc2c(CCCC(c3ccc(cc3)C(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H32F3NO2/c32-16-2-17-35-18-15-27(20-35)37-26-12-9-22(10-13-26)30-28(21-5-7-23(8-6-21)31(33)34)4-1-3-24-19-25(36)11-14-29(24)30/h5-14,19,27,31,36H,1-4,15-18,20H2/t27-/m0/s1 OKRLGTWOCQUULB-MHZLTWQESA-N 263809 6-[4- (difluoro- methyl)- phenyl]-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 142 Estrogen receptor [Y537S] 64.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263809&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233358 377002711 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501287 Oc1ccc2c(CCCC(c3ccc(OC(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H31F4NO3/c32-16-2-17-36-18-15-24(19-36)38-22-11-7-21(8-12-22)29-25(20-5-9-23(10-6-20)39-31(34)35)3-1-4-27-26(29)13-14-28(37)30(27)33/h5-14,24,31,37H,1-4,15-19H2/t24-/m0/s1 DGYOZKNOVPHTRQ-DEOSSOPVSA-N 263810 6-[4- (difluoro- methoxy)- phenyl]-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 143 Estrogen receptor [Y537S] 57.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263810&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232797 377002712 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501290 Oc1ccc2c(CCCC(c3cc(F)c(OC(F)(F)F)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H29F6NO3/c32-12-2-13-38-14-11-24(18-38)40-23-8-5-19(6-9-23)29-25(4-1-3-20-15-22(39)7-10-26(20)29)21-16-27(33)30(28(34)17-21)41-31(35,36)37/h5-10,15-17,24,39H,1-4,11-14,18H2/t24-/m0/s1 YXMFALIKMIOEDY-DEOSSOPVSA-N 263811 6-[3,5- difluoro-4- (trifluoro- methoxy)- phenyl]-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 144 Estrogen receptor [Y537S] 645 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263811&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232406 377002713 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501293 Cc1cc(OC(F)F)ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34F3NO3/c1-21-18-26(39-32(34)35)11-13-28(21)30-5-2-4-23-19-24(37)8-12-29(23)31(30)22-6-9-25(10-7-22)38-27-14-17-36(20-27)16-3-15-33/h6-13,18-19,27,32,37H,2-5,14-17,20H2,1H3/t27-/m0/s1 DEWHNSKFSMRHHV-MHZLTWQESA-N 263813 6-[4- (difluoro- methoxy)-2- methyl- phenyl]-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 145 Estrogen receptor [Y537S] 28.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263813&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232832 377002715 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501137 COc1ccc(c(F)c1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H32F3NO3/c1-37-28-13-12-27(30(33)31(28)34)26-5-2-4-21-18-22(36)8-11-25(21)29(26)20-6-9-23(10-7-20)38-24-14-17-35(19-24)16-3-15-32/h6-13,18,24,36H,2-5,14-17,19H2,1H3/t24-/m0/s1 DMOPTXJOHNKNJJ-DEOSSOPVSA-N 263759 6-(2,3- difluoro-4- methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 93 Estrogen receptor [Y537S] 24.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263759&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232822 377002661 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501140 Oc1ccc2c(CCCC(c3ccc(SC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31F4NO2S/c32-16-2-17-36-18-15-26(20-36)38-25-10-5-22(6-11-25)30-28(4-1-3-23-19-24(37)9-14-29(23)30)21-7-12-27(13-8-21)39-31(33,34)35/h5-14,19,26,37H,1-4,15-18,20H2/t26-/m0/s1 KSHPIANNCSKMIT-SANMLTNESA-N 263760 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methyl- sulfanyl)- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 94 Estrogen receptor [Y537S] 322 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263760&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233149 377002662 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501143 CCOc1ccc(cc1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H35ClFNO3/c1-2-37-31-14-9-24(20-30(31)33)28-6-3-5-23-19-25(36)10-13-29(23)32(28)22-7-11-26(12-8-22)38-27-15-18-35(21-27)17-4-16-34/h7-14,19-20,27,36H,2-6,15-18,21H2,1H3/t27-/m0/s1 OJXZADGLWGGQLZ-MHZLTWQESA-N 263761 6-(3- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 95 Estrogen receptor [Y537S] 150 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263761&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232348 377002663 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501146 Cc1cncc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H33FN2O2/c1-21-16-24(19-32-18-21)28-5-2-4-23-17-25(34)8-11-29(23)30(28)22-6-9-26(10-7-22)35-27-12-15-33(20-27)14-3-13-31/h6-11,16-19,27,34H,2-5,12-15,20H2,1H3/t27-/m0/s1 SSNQTXXDEUCRDU-MHZLTWQESA-N 263762 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(5- methyl-3- pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 96 Estrogen receptor [Y537S] 196 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263762&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232827 377002664 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501149 COc1ccc(c(C)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H35FN2O3/c1-21-27(13-14-30(33-21)36-2)29-6-3-5-23-19-24(35)9-12-28(23)31(29)22-7-10-25(11-8-22)37-26-15-18-34(20-26)17-4-16-32/h7-14,19,26,35H,3-6,15-18,20H2,1-2H3/t26-/m0/s1 CPNSGUCAWMDTMD-SANMLTNESA-N 263763 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(6- methoxy- 2-methyl- 3-pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 97 Estrogen receptor [Y537S] 78.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263763&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233374 377002665 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501152 CC1(C)Cc2cc(ccc2O1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C34H38FNO3/c1-34(2)21-26-19-25(9-14-32(26)39-34)30-6-3-5-24-20-27(37)10-13-31(24)33(30)23-7-11-28(12-8-23)38-29-15-18-36(22-29)17-4-16-35/h7-14,19-20,29,37H,3-6,15-18,21-22H2,1-2H3/t29-/m0/s1 ZHMSQYPPKMWBDO-LJAQVGFWSA-N 263764 6-(2,2- dimethyl- 3H- benzo- furan-5-yl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 98 Estrogen receptor [Y537S] 12.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263764&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232412 377002666 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501155 COc1ncc(cc1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H32ClFN2O3/c1-36-30-28(31)17-22(18-33-30)26-5-2-4-21-16-23(35)8-11-27(21)29(26)20-6-9-24(10-7-20)37-25-12-15-34(19-25)14-3-13-32/h6-11,16-18,25,35H,2-5,12-15,19H2,1H3/t25-/m0/s1 VFTYBKOLJBOEKG-VWLOTQADSA-N 263765 6-(5- chloro-6- methoxy- 3-pyridyl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 99 Estrogen receptor [Y537S] 280 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263765&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232343 377002667 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501158 CCOc1cc(C)c(cc1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C34H40FNO3/c1-4-38-33-20-23(2)32(19-24(33)3)31-8-5-7-26-21-27(37)11-14-30(26)34(31)25-9-12-28(13-10-25)39-29-15-18-36(22-29)17-6-16-35/h9-14,19-21,29,37H,4-8,15-18,22H2,1-3H3/t29-/m0/s1 AMBZOWKFNZTHQE-LJAQVGFWSA-N 263766 6-(4- ethoxy- 2,5- dimethyl- phenyl)- 5-[4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 100 Estrogen receptor [Y537S] 1014 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263766&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233367 377002668 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501161 COc1ncc(cc1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H35FN2O3/c1-21-17-24(19-33-31(21)36-2)28-6-3-5-23-18-25(35)9-12-29(23)30(28)22-7-10-26(11-8-22)37-27-13-16-34(20-27)15-4-14-32/h7-12,17-19,27,35H,3-6,13-16,20H2,1-2H3/t27-/m0/s1 HLGOXHMPCGSYOU-MHZLTWQESA-N 263767 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(6- methoxy- 5-methyl- 3-pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 101 Estrogen receptor [Y537S] 163 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263767&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232849 377002669 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501164 COc1ncc(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H32F2N2O3/c1-36-30-28(32)17-22(18-33-30)26-5-2-4-21-16-23(35)8-11-27(21)29(26)20-6-9-24(10-7-20)37-25-12-15-34(19-25)14-3-13-31/h6-11,16-18,25,35H,2-5,12-15,19H2,1H3/t25-/m0/s1 FQORKISEXBYFCV-VWLOTQADSA-N 263768 6-(5-fluoro- 6- methoxy- 3-pyridyl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 102 Estrogen receptor [Y537S] 71.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263768&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233178 377002670 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501167 CCOc1ccc(c(F)c1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34ClF2NO3/c1-2-38-29-14-13-28(32(35)31(29)33)27-6-3-5-22-19-23(37)9-12-26(22)30(27)21-7-10-24(11-8-21)39-25-15-18-36(20-25)17-4-16-34/h7-14,19,25,37H,2-6,15-18,20H2,1H3/t25-/m0/s1 HLXIDXIGUJDXFJ-VWLOTQADSA-N 263769 6-(3- chloro-4- ethoxy-2- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 103 Estrogen receptor [Y537S] 55.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263769&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233353 377002671 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501170 COc1ccc(c(F)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H32F2N2O3/c1-36-28-13-12-27(30(32)33-28)26-5-2-4-21-18-22(35)8-11-25(21)29(26)20-6-9-23(10-7-20)37-24-14-17-34(19-24)16-3-15-31/h6-13,18,24,35H,2-5,14-17,19H2,1H3/t24-/m0/s1 SCILRDFPHRKKHC-DEOSSOPVSA-N 263770 6-(2-fluoro- 6-methoxy- 3-pyridyl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 104 Estrogen receptor [Y537S] 17.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263770&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232374 377002672 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501173 COc1c(F)cc(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H32F3NO3/c1-37-31-28(33)17-22(18-29(31)34)26-5-2-4-21-16-23(36)8-11-27(21)30(26)20-6-9-24(10-7-20)38-25-12-15-35(19-25)14-3-13-32/h6-11,16-18,25,36H,2-5,12-15,19H2,1H3/t25-/m0/s1 DEOFNJZMNGWDHC-VWLOTQADSA-N 263771 6-(3,5- difluoro-4- methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 105 Estrogen receptor [Y537S] 81.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263771&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232407 377002673 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501176 CCN1CCc2cc(ccc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C34H39FN2O2/c1-2-37-20-15-27-21-26(9-14-33(27)37)31-6-3-5-25-22-28(38)10-13-32(25)34(31)24-7-11-29(12-8-24)39-30-16-19-36(23-30)18-4-17-35/h7-14,21-22,30,38H,2-6,15-20,23H2,1H3/t30-/m0/s1 YVRRYWYIZWPWHP-PMERELPUSA-N 263772 US9714221, Example 106 Estrogen receptor [Y537S] 607 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263772&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232809 377002674 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501179 CCOc1ncc(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H34FN3O3/c1-2-36-30-32-18-23(19-33-30)27-6-3-5-22-17-24(35)9-12-28(22)29(27)21-7-10-25(11-8-21)37-26-13-16-34(20-26)15-4-14-31/h7-12,17-19,26,35H,2-6,13-16,20H2,1H3/t26-/m0/s1 UBSWKNSSCUADIN-SANMLTNESA-N 263773 US9714221, Example 107 Estrogen receptor [Y537S] 507 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263773&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232829 377002675 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501182 COc1ccc(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H33FN2O3/c1-35-29-13-8-23(19-32-29)27-5-2-4-22-18-24(34)9-12-28(22)30(27)21-6-10-25(11-7-21)36-26-14-17-33(20-26)16-3-15-31/h6-13,18-19,26,34H,2-5,14-17,20H2,1H3/t26-/m0/s1 RHMGATBKFUCRAK-SANMLTNESA-N 263774 US9714221, Example 108 Estrogen receptor [Y537S] 19.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263774&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232786 377002676 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501296 Cc1cc(OC(F)(F)F)ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H33F4NO3/c1-21-18-26(40-32(34,35)36)11-13-28(21)30-5-2-4-23-19-24(38)8-12-29(23)31(30)22-6-9-25(10-7-22)39-27-14-17-37(20-27)16-3-15-33/h6-13,18-19,27,38H,2-5,14-17,20H2,1H3/t27-/m0/s1 CBUGHJPEMSUFBA-MHZLTWQESA-N 263814 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[2- methyl-4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 146 Estrogen receptor [Y537S] 67.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263814&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233392 377002716 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501299 CN1C(=O)COc2ccc(cc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H35FN2O4/c1-35-30-19-24(8-13-31(30)39-21-32(35)38)28-5-2-4-23-18-25(37)9-12-29(23)33(28)22-6-10-26(11-7-22)40-27-14-17-36(20-27)16-3-15-34/h6-13,18-19,27,37H,2-5,14-17,20-21H2,1H3/t27-/m0/s1 YXSYPBJKMIGHKB-MHZLTWQESA-N 263815 6-[5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]-4- methyl- 1,4- benzoxazin- 3-one::US9714221, Example 147 Estrogen receptor [Y537S] 583 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263815&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233183 377002717 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501302 Oc1ccc2c(CCCC(c3ccc4OCC(=O)Nc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H33FN2O4/c33-14-2-15-35-16-13-26(19-35)39-25-9-5-21(6-10-25)32-27(4-1-3-22-17-24(36)8-11-28(22)32)23-7-12-30-29(18-23)34-31(37)20-38-30/h5-12,17-18,26,36H,1-4,13-16,19-20H2,(H,34,37)/t26-/m0/s1 XRCUOACYAABUMF-SANMLTNESA-N 263816 6-[5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]-4H-1,4- benzoxazin- 3-one::US9714221, Example 148 Estrogen receptor [Y537S] 916 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263816&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232316 377002718 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501305 CCOc1ccc(c(Cl)c1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34Cl2FNO3/c1-2-38-29-14-13-28(31(33)32(29)34)27-6-3-5-22-19-23(37)9-12-26(22)30(27)21-7-10-24(11-8-21)39-25-15-18-36(20-25)17-4-16-35/h7-14,19,25,37H,2-6,15-18,20H2,1H3/t25-/m0/s1 KGMZYAWKOUNEBL-VWLOTQADSA-N 263817 6-(2,3- dichloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 149 Estrogen receptor [Y537S] 72.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263817&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233152 377002719 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501308 Cc1cc(ccc1OC(F)(F)F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H33F4NO3/c1-21-18-24(8-13-30(21)40-32(34,35)36)28-5-2-4-23-19-25(38)9-12-29(23)31(28)22-6-10-26(11-7-22)39-27-14-17-37(20-27)16-3-15-33/h6-13,18-19,27,38H,2-5,14-17,20H2,1H3/t27-/m0/s1 PZIYCJGUXDJHCT-MHZLTWQESA-N 263818 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[3- methyl-4- (trifluoro- methoxy)- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 150 Estrogen receptor [Y537S] 2148 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263818&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232886 377002720 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501311 Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)c(Cl)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30ClF4NO3/c32-28-18-22(7-12-29(28)40-31(34,35)36)26-4-1-3-21-17-23(38)8-11-27(21)30(26)20-5-9-24(10-6-20)39-25-13-16-37(19-25)15-2-14-33/h5-12,17-18,25,38H,1-4,13-16,19H2/t25-/m0/s1 ZBNWPGLUONOBAF-VWLOTQADSA-N 263820 6-[3- chloro-4- (trifluoro- methoxy)- phenyl]-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 151 Estrogen receptor [Y537S] >4000 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263820&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232792 377002722 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501314 Oc1ccc2c(CCCC(c3cccc4ncccc34)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C33H33FN2O2/c34-17-4-19-36-20-16-27(22-36)38-26-13-10-23(11-14-26)33-28-15-12-25(37)21-24(28)5-1-7-31(33)29-6-2-9-32-30(29)8-3-18-35-32/h2-3,6,8-15,18,21,27,37H,1,4-5,7,16-17,19-20,22H2/t27-/m0/s1 KOJXZNCKTBXCGS-MHZLTWQESA-N 263821 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(5- quinolyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 152 Estrogen receptor [Y537S] 132 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263821&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232388 377002723 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501317 Oc1ccc2c(CCCC(c3ccncc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H31FN2O2/c30-14-2-17-32-18-13-26(20-32)34-25-8-5-22(6-9-25)29-27(21-11-15-31-16-12-21)4-1-3-23-19-24(33)7-10-28(23)29/h5-12,15-16,19,26,33H,1-4,13-14,17-18,20H2/t26-/m0/s1 VQJJJXIRLQIHGO-SANMLTNESA-N 263822 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 153 Estrogen receptor [Y537S] 47.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263822&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233406 377002724 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501320 Oc1ccc2c(CCCC(c3cccnc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H31FN2O2/c30-14-3-16-32-17-13-26(20-32)34-25-10-7-21(8-11-25)29-27(23-5-2-15-31-19-23)6-1-4-22-18-24(33)9-12-28(22)29/h2,5,7-12,15,18-19,26,33H,1,3-4,6,13-14,16-17,20H2/t26-/m0/s1 NCANDHQUQRCDIG-SANMLTNESA-N 263823 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 154 Estrogen receptor [Y537S] 117 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263823&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232819 377002725 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501323 Oc1ccc2c(CCCC(c3ccc(nc3Cl)C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H29ClF4N2O2/c31-29-26(11-12-27(36-29)30(33,34)35)25-4-1-3-20-17-21(38)7-10-24(20)28(25)19-5-8-22(9-6-19)39-23-13-16-37(18-23)15-2-14-32/h5-12,17,23,38H,1-4,13-16,18H2/t23-/m0/s1 MZSRITODEUFHIC-QHCPKHFHSA-N 263825 6-[2- chloro-6- (trifluoro- methyl)-3- pyridyl]-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 155 Estrogen receptor [Y537S] 141 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263825&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232391 377002727 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501326 CC(C)(C)OC(=O)N1CCOc2ccc(cc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C37H43FN2O5/c1-37(2,3)45-36(42)40-20-21-43-34-15-10-27(23-33(34)40)31-7-4-6-26-22-28(41)11-14-32(26)35(31)25-8-12-29(13-9-25)44-30-16-19-39(24-30)18-5-17-38/h8-15,22-23,30,41H,4-7,16-21,24H2,1-3H3/t30-/m0/s1 LZFAPWSEEUFPNM-PMERELPUSA-N 263826 US9714221, Example 156::tert-butyl 6-[5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]-2,3- dihydro-1,4- benzoxazine-4- carboxylate Estrogen receptor [Y537S] 1006 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263826&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232324 377002728 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501329 Oc1ccc2c(CCCC(c3ccc(SC(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H32F3NO2S/c32-16-2-17-35-18-15-26(20-35)37-25-10-5-22(6-11-25)30-28(21-7-12-27(13-8-21)38-31(33)34)4-1-3-23-19-24(36)9-14-29(23)30/h5-14,19,26,31,36H,1-4,15-18,20H2/t26-/m0/s1 YTEDSDFWRDLHMY-SANMLTNESA-N 263827 6-[4- (difluoro- methylsulfanyl)- phenyl]- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 157 Estrogen receptor [Y537S] 53.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263827&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232813 377002729 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501332 Oc1ccc2c(CCCC(c3ccc4CCCNc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C33H37FN2O2/c34-16-3-18-36-19-15-29(22-36)38-28-12-9-24(10-13-28)33-30(6-1-4-25-20-27(37)11-14-31(25)33)26-8-7-23-5-2-17-35-32(23)21-26/h7-14,20-21,29,35,37H,1-6,15-19,22H2/t29-/m0/s1 CSAIUIOJCISNNV-LJAQVGFWSA-N 263828 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6- (1,2,3,4- tetrahydro quinolin-7- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 158 Estrogen receptor [Y537S] 63.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263828&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232843 377002730 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501335 OC(=O)c1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H31F4NO4/c33-16-2-17-37-18-15-27(20-37)40-25-10-7-22(8-11-25)30-28(21-5-12-26(13-6-21)41-32(34,35)36)4-1-3-23-19-24(31(38)39)9-14-29(23)30/h5-14,19,27H,1-4,15-18,20H2,(H,38,39)/t27-/m0/s1 KVZDTTJONYGOOD-MHZLTWQESA-N 263829 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2- carboxylic acid::US9714221, Example 159 Estrogen receptor [Y537S] 2563 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263829&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232413 377002731 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501338 Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H29F6NO3/c32-14-2-15-38-16-13-22(18-38)40-20-7-5-19(6-8-20)29-24(3-1-4-26-25(29)11-12-28(39)30(26)34)23-10-9-21(17-27(23)33)41-31(35,36)37/h5-12,17,22,39H,1-4,13-16,18H2/t22-/m0/s1 ZLJAZMZUMHBKHP-QFIPXVFZSA-N 263830 1-fluoro-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[2- fluoro-4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 160 Estrogen receptor [Y537S] 110 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263830&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232835 377002732 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501185 COc1cc(ccn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C30H33FN2O3/c1-35-29-19-23(12-15-32-29)27-5-2-4-22-18-24(34)8-11-28(22)30(27)21-6-9-25(10-7-21)36-26-13-17-33(20-26)16-3-14-31/h6-12,15,18-19,26,34H,2-5,13-14,16-17,20H2,1H3/t26-/m0/s1 BYGJQCMFBJUYMF-SANMLTNESA-N 263775 US9714221, Example 109 Estrogen receptor [Y537S] 17.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263775&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232885 377002677 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501188 CCOc1ncc(cc1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H37FN2O3/c1-3-37-32-22(2)18-25(20-34-32)29-7-4-6-24-19-26(36)10-13-30(24)31(29)23-8-11-27(12-9-23)38-28-14-17-35(21-28)16-5-15-33/h8-13,18-20,28,36H,3-7,14-17,21H2,1-2H3/t28-/m0/s1 ZLEJUDODDVBETP-NDEPHWFRSA-N 263776 6-(6- ethoxy-5- methyl-3- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 110 Estrogen receptor [Y537S] 168 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263776&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232897 377002678 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501191 COc1ccc(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H33F2NO3/c1-36-30-13-8-23(19-29(30)33)27-5-2-4-22-18-24(35)9-12-28(22)31(27)21-6-10-25(11-7-21)37-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1 JOGVMWOWLWIYFR-SANMLTNESA-N 263777 6-(3-fluoro- 4-methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 111 Estrogen receptor [Y537S] 67.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263777&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232392 377002679 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501194 COc1c(F)ccc(c1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H32F3NO3/c1-37-31-28(33)13-12-27(30(31)34)26-5-2-4-21-18-22(36)8-11-25(21)29(26)20-6-9-23(10-7-20)38-24-14-17-35(19-24)16-3-15-32/h6-13,18,24,36H,2-5,14-17,19H2,1H3/t24-/m0/s1 RHOUMLBJXKLDGT-DEOSSOPVSA-N 263778 6-(2,4- difluoro-3- methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 112 Estrogen receptor [Y537S] 46.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263778&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232784 377002680 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501197 Cc1cc(ccc1Cl)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1 InChI=1S/C31H32ClF2NO2/c1-20-18-22(8-12-28(20)32)25-4-2-5-27-26(11-13-29(36)31(27)34)30(25)21-6-9-23(10-7-21)37-24-14-17-35(19-24)16-3-15-33/h6-13,18,24,36H,2-5,14-17,19H2,1H3/t24-/m0/s1 CHQNGBAKHJXABH-DEOSSOPVSA-N 263779 6-(4- chloro-3- methyl- phenyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol1-fluoro-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methoxy)- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 113 Estrogen receptor [Y537S] 434 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263779&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233362 377002681 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501200 Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H30F5NO3/c32-16-2-17-37-18-15-24(19-37)39-22-9-7-21(8-10-22)29-25(20-5-11-23(12-6-20)40-31(34,35)36)3-1-4-27-26(29)13-14-28(38)30(27)33/h5-14,24,38H,1-4,15-19H2/t24-/m0/s1 FRLMIEGPPXGCAE-DEOSSOPVSA-N 263780 US9714221, Example 114 Estrogen receptor [Y537S] 242 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263780&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232332 377002682 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501203 Oc1ccc2c(CCCC(c3ccc(F)cc3C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H29F6NO2/c32-14-2-15-38-16-13-22(18-38)40-21-8-5-19(6-9-21)29-24(23-10-7-20(33)17-27(23)31(35,36)37)3-1-4-26-25(29)11-12-28(39)30(26)34/h5-12,17,22,39H,1-4,13-16,18H2/t22-/m0/s1 VLXBAMWWHHGTLG-QFIPXVFZSA-N 263781 1-fluoro-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 6-[4- fluoro-2- (trifluoro- methyl)phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 115 Estrogen receptor [Y537S] 71.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263781&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232423 377002683 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501206 Oc1ccc2c(CCCC(c3ccc(OC(F)F)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31F4NO3/c32-14-2-15-36-16-13-25(19-36)38-23-8-5-20(6-9-23)30-26-11-7-22(37)17-21(26)3-1-4-28(30)27-12-10-24(18-29(27)33)39-31(34)35/h5-12,17-18,25,31,37H,1-4,13-16,19H2/t25-/m0/s1 DHSYBZZHWIZSDW-VWLOTQADSA-N 263782 6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 116 Estrogen receptor [Y537S] 25.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263782&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232868 377002684 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501209 Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H30F5NO3/c32-14-2-15-37-16-13-25(19-37)39-23-8-5-20(6-9-23)30-26-11-7-22(38)17-21(26)3-1-4-28(30)27-12-10-24(18-29(27)33)40-31(34,35)36/h5-12,17-18,25,38H,1-4,13-16,19H2/t25-/m0/s1 CEJJVMZJXQOISU-VWLOTQADSA-N 263783 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[2- fluoro-4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 117 Estrogen receptor [Y537S] 163 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263783&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232321 377002685 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501212 Oc1ccc2c(CCCC(c3ccc(Cl)nc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H29Cl2FN2O2/c30-27-12-11-26(29(31)33-27)25-4-1-3-20-17-21(35)7-10-24(20)28(25)19-5-8-22(9-6-19)36-23-13-16-34(18-23)15-2-14-32/h5-12,17,23,35H,1-4,13-16,18H2/t23-/m0/s1 DFJLSOSHRDXYSY-QHCPKHFHSA-N 263784 6-(2,6- dichloro-3- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 118 Estrogen receptor [Y537S] 164 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263784&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232788 377002686 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501215 Oc1ccc2c(CCCC(c3ccc(OCC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H33F4NO3/c33-16-2-17-37-18-15-28(20-37)40-27-12-7-23(8-13-27)31-29(4-1-3-24-19-25(38)9-14-30(24)31)22-5-10-26(11-6-22)39-21-32(34,35)36/h5-14,19,28,38H,1-4,15-18,20-21H2/t28-/m0/s1 QJPDFGBGRBUKCZ-NDEPHWFRSA-N 263785 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (2,2,2- trifluoro- ethoxy)phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 119 Estrogen receptor [Y537S] 714 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263785&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232778 377002687 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501218 CCOc1c(F)cc(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C32H34F3NO3/c1-2-38-32-29(34)18-23(19-30(32)35)27-6-3-5-22-17-24(37)9-12-28(22)31(27)21-7-10-25(11-8-21)39-26-13-16-36(20-26)15-4-14-33/h7-12,17-19,26,37H,2-6,13-16,20H2,1H3/t26-/m0/s1 AOYHMYQYNDRVNR-SANMLTNESA-N 263786 6-(4- ethoxy- 3,5-difluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 120 Estrogen receptor [Y537S] 357 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263786&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232875 377002688 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501221 Oc1ccc2c(CCCC(c3ccc(Cl)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C30H29ClF3NO2/c31-20-7-10-23(27(33)17-20)24-3-1-4-26-25(11-12-28(36)30(26)34)29(24)19-5-8-21(9-6-19)37-22-13-16-35(18-22)15-2-14-32/h5-12,17,22,36H,1-4,13-16,18H2/t22-/m0/s1 WGTZQBMGWDDRRV-QFIPXVFZSA-N 263787 6-(4- chloro-2- fluoro- phenyl)-1- fluoro-5-[4- (3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 121 Estrogen receptor [Y537S] 56.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263787&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232776 377002689 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501224 Oc1ccc2c(CCCC(c3cccc(F)c3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C30H29ClF3NO2/c31-29-24(5-2-7-26(29)33)22-4-1-6-25-23(12-13-27(36)30(25)34)28(22)19-8-10-20(11-9-19)37-21-14-17-35(18-21)16-3-15-32/h2,5,7-13,21,36H,1,3-4,6,14-18H2/t21-/m0/s1 NANKONNNILFVRM-NRFANRHFSA-N 263788 6-(2- chloro-3- fluoro- phenyl)-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9-dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 122 Estrogen receptor [Y537S] 24.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263788&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232785 377002690 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501227 Cc1cc(ccc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1)C(F)(F)F InChI=1S/C32H32F5NO2/c1-20-18-22(32(35,36)37)8-11-25(20)26-4-2-5-28-27(12-13-29(39)31(28)34)30(26)21-6-9-23(10-7-21)40-24-14-17-38(19-24)16-3-15-33/h6-13,18,24,39H,2-5,14-17,19H2,1H3/t24-/m0/s1 NUKZCXZUKQYFDP-DEOSSOPVSA-N 263790 1-fluoro-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 6-[2- methyl-4- (trifluoro- methyl) phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 123 Estrogen receptor [Y537S] 46.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263790&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232333 377002692 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501230 Oc1ccc2c(CCCC(c3ccc(cc3)C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H30F5NO2/c32-16-2-17-37-18-15-24(19-37)39-23-11-7-21(8-12-23)29-25(20-5-9-22(10-6-20)31(34,35)36)3-1-4-27-26(29)13-14-28(38)30(27)33/h5-14,24,38H,1-4,15-19H2/t24-/m0/s1 UYQYUSVAJRLGNB-DEOSSOPVSA-N 263791 1-fluoro-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 6-[4- (trifluoro- methyl)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 124 Estrogen receptor [Y537S] 170 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263791&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232329 377002693 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501341 Oc1ccc2c(CCCC(c3ccc(SC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H30F5NO2S/c32-16-2-17-37-18-15-23(19-37)39-22-9-5-21(6-10-22)29-25(20-7-11-24(12-8-20)40-31(34,35)36)3-1-4-27-26(29)13-14-28(38)30(27)33/h5-14,23,38H,1-4,15-19H2/t23-/m0/s1 IFCIPJLVEMMPOX-QHCPKHFHSA-N 263831 1-fluoro-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methyl- sulfanyl)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 161 Estrogen receptor [Y537S] 169 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263831&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232882 377002733 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501344 Oc1ccc2c(CCCC(c3cc(F)c(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C30H29Cl2F2NO2/c31-27-17-28(32)29(34)16-26(27)25-4-1-3-20-15-21(36)7-10-24(20)30(25)19-5-8-22(9-6-19)37-23-11-14-35(18-23)13-2-12-33/h5-10,15-17,23,36H,1-4,11-14,18H2/t23-/m0/s1 CTQMUZILNPDROS-QHCPKHFHSA-N 263832 6-(2,4- dichloro-5- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-yl] dihydrogen phosphate::US9714221, Example 162 Estrogen receptor [Y537S] 159 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263832&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232389 377002734 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501347 OP(O)(=O)Oc1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H32F4NO6P/c32-16-2-17-36-18-15-27(20-36)40-24-9-7-22(8-10-24)30-28(21-5-11-25(12-6-21)41-31(33,34)35)4-1-3-23-19-26(13-14-29(23)30)42-43(37,38)39/h5-14,19,27H,1-4,15-18,20H2,(H2,37,38,39)/t27-/m0/s1 YICAMVNYUFULBB-MHZLTWQESA-N 263833 US9714221, Example 163::[5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-6-[4-(trifluoromethoxy)phenyl]-8,9-dihydro-7H-benzo[7]annulen-2-yl] dihydrogen phosphate Estrogen receptor [Y537S] 121 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263833&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232802 377002735 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501350 Cc1oncc1C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C28H31FN2O3/c1-19-27(17-30-34-19)26-5-2-4-21-16-22(32)8-11-25(21)28(26)20-6-9-23(10-7-20)33-24-12-15-31(18-24)14-3-13-29/h6-11,16-17,24,32H,2-5,12-15,18H2,1H3/t24-/m0/s1 VZBQZXRETZXXFB-DEOSSOPVSA-N 263834 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(5- methyl- isoxazol-4- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 164 Estrogen receptor [Y537S] 27.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263834&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232395 377002736 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501353 Oc1ccc2c(CCCC(c3ccc(OC(F)F)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F InChI=1S/C31H30F5NO3/c32-14-2-15-37-16-13-22(18-37)39-20-7-5-19(6-8-20)29-24(23-10-9-21(17-27(23)33)40-31(35)36)3-1-4-26-25(29)11-12-28(38)30(26)34/h5-12,17,22,31,38H,1-4,13-16,18H2/t22-/m0/s1 GQXDOOQZYUMRGG-QFIPXVFZSA-N 263837 6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 165 Estrogen receptor [Y537S] 299 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263837&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232762 377002739 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501356 Oc1ccc2c(CCCC(c3ccc(cc3)S(=O)(=O)C(F)(F)F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31F4NO4S/c32-16-2-17-36-18-15-26(20-36)40-25-10-5-22(6-11-25)30-28(4-1-3-23-19-24(37)9-14-29(23)30)21-7-12-27(13-8-21)41(38,39)31(33,34)35/h5-14,19,26,37H,1-4,15-18,20H2/t26-/m0/s1 LFSONZKWQZVENU-SANMLTNESA-N 263838 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methyl- sulfonyl)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 166 Estrogen receptor [Y537S] 33.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263838&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232390 377002740 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501359 Oc1ccc2c(CCCC(c3ccc4OCCNc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H35FN2O3/c33-14-2-16-35-17-13-27(21-35)38-26-9-5-22(6-10-26)32-28(4-1-3-23-19-25(36)8-11-29(23)32)24-7-12-31-30(20-24)34-15-18-37-31/h5-12,19-20,27,34,36H,1-4,13-18,21H2/t27-/m0/s1 WJFMTWIDUKISBI-MHZLTWQESA-N 263839 6-(3,4- dihydro- 2H-1,4- benzo- xazin-6-yl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol hydro- chloride::US9714221, Example 167 Estrogen receptor [Y537S] >4000 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263839&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232394 377002741 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501362 OC(=O)c1ccc2c(CCCC(c3ccc(OC(F)(F)F)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C32H30F5NO4/c33-14-2-15-38-16-13-25(19-38)41-23-8-5-20(6-9-23)30-26-11-7-22(31(39)40)17-21(26)3-1-4-28(30)27-12-10-24(18-29(27)34)42-32(35,36)37/h5-12,17-18,25H,1-4,13-16,19H2,(H,39,40)/t25-/m0/s1 LPDBLNJQOQRFCU-VWLOTQADSA-N 263841 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[2- fluoro-4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2- carboxylic acid::US9714221, Example 168 Estrogen receptor [Y537S] 787 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263841&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232928 377002743 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501365 Oc1ccc2c(CCCC(c3cnoc3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C27H29FN2O3/c28-12-2-13-30-14-11-24(17-30)33-23-8-5-19(6-9-23)27-25(21-16-29-32-18-21)4-1-3-20-15-22(31)7-10-26(20)27/h5-10,15-16,18,24,31H,1-4,11-14,17H2/t24-/m0/s1 ZNHBSEGNGVLHHX-DEOSSOPVSA-N 263842 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6- isoxazol-4- yl-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 169 Estrogen receptor [Y537S] 89.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263842&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232820 377002744 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501368 CCOc1ncc(cc1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C31H34F2N2O3/c1-2-37-31-29(33)18-23(19-34-31)27-6-3-5-22-17-24(36)9-12-28(22)30(27)21-7-10-25(11-8-21)38-26-13-16-35(20-26)15-4-14-32/h7-12,17-19,26,36H,2-6,13-16,20H2,1H3/t26-/m0/s1 XAAGOGHVKBWMQX-SANMLTNESA-N 263843 6-(6- ethoxy-5- fluoro-3- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 170 Estrogen receptor [Y537S] 20.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263843&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232793 377002745 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501371 Oc1ccc2c(CCCC(c3ccc(O)nc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C29H30F2N2O3/c30-14-2-15-33-16-13-23(18-33)36-22-8-5-19(6-9-22)28-24-10-7-21(34)17-20(24)3-1-4-25(28)26-11-12-27(35)32-29(26)31/h5-12,17,23,34H,1-4,13-16,18H2,(H,32,35)/t23-/m0/s1 WCYACXZGNADIBD-QHCPKHFHSA-N 263844 6-fluoro-5- [5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]pyridin- 2-ol::US9714221, Example 171 Estrogen receptor [Y537S] 1072 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263844&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233401 377002746 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501374 CC(C)(C)c1cc(cc(F)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H38F2N2O2/c1-33(2,3)30-19-24(20-31(35)36-30)28-7-4-6-23-18-25(38)10-13-29(23)32(28)22-8-11-26(12-9-22)39-27-14-17-37(21-27)16-5-15-34/h8-13,18-20,27,38H,4-7,14-17,21H2,1-3H3/t27-/m0/s1 RXZDGXJRVUQORH-MHZLTWQESA-N 263845 6-(6-tert- butyl-2- fluoro-4- pyridyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 172 Estrogen receptor [Y537S] 1495 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263845&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232780 377002747 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501377 C[Si](C)(C)c1ccc(cc1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 InChI=1S/C33H40FNO2Si/c1-38(2,3)30-15-10-24(11-16-30)31-7-4-6-26-22-27(36)12-17-32(26)33(31)25-8-13-28(14-9-25)37-29-18-21-35(23-29)20-5-19-34/h8-17,22,29,36H,4-7,18-21,23H2,1-3H3/t29-/m0/s1 AAJBLUFPXQYNOW-LJAQVGFWSA-N 263846 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- (trimethyl- silyl- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(2,2- dimethyl- indolin-5-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2- carboxylic acid hydrochloride::US9714221, Example 173 Estrogen receptor [Y537S] 429 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263846&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 135120972 377002748 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501380 CC1(C)Cc2cc(ccc2N1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(cc2CCC1)C(O)=O InChI=1S/C35H39FN2O3/c1-35(2)21-27-20-25(10-14-32(27)37-35)30-6-3-5-24-19-26(34(39)40)9-13-31(24)33(30)23-7-11-28(12-8-23)41-29-15-18-38(22-29)17-4-16-36/h7-14,19-20,29,37H,3-6,15-18,21-22H2,1-2H3,(H,39,40)/t29-/m0/s1 XGPVTAWGBZBRSK-LJAQVGFWSA-N 263847 6-(2,2-dimethylindolin-5-yl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid::US9714221, Example 174 Estrogen receptor [Y537S] 14.0 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263847&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232831 377002749 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501383 Oc1ccc2c(CCCC(c3ccc4scnc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 InChI=1S/C31H31FN2O2S/c32-14-2-15-34-16-13-26(19-34)36-25-9-5-21(6-10-25)31-27(23-7-12-30-29(18-23)33-20-37-30)4-1-3-22-17-24(35)8-11-28(22)31/h5-12,17-18,20,26,35H,1-4,13-16,19H2/t26-/m0/s1 VLIVKBWDSAJAOS-SANMLTNESA-N 263848 6-(1,3- benzo- thiazol-5-yl)- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 175 Estrogen receptor [Y537S] 435 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263848&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130233194 377002750 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 501386 Cc1nc2cc(ccc2[nH]1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1 263849 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- methyl-1H- benzimi- dazol-5-yl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 176 Estrogen receptor [Y537S] 2911 7.4 25.00 C US Patent 10.7270/Q2N58PB1 aid1795286 US9714221 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=263849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=263849&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 130232883 377002751 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903668 Oc1ccc2c3C(Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2 UVBQMXOKKDCBJN-UHFFFAOYSA-N 443428 Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol::US10654866, Example 1::US11117902, Example 1::US11634426, Example 1 Estrogen receptor [Y537S] 5.80 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443428&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559745 440074605 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903670 Oc1ccc2c3[C@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m1/s1 UVBQMXOKKDCBJN-MUUNZHRXSA-N 443429 US10654866, Example 1A::US11117902, Example 1B::US11634426, Example 1A Estrogen receptor [Y537S] 57.2 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443429&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603228 440074606 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903672 Oc1ccc2c3[C@@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m0/s1 UVBQMXOKKDCBJN-NDEPHWFRSA-N 443430 US10654866, Example 1B::US11117902, Example 1A::US11634426, Example 1B Estrogen receptor [Y537S] 2.79 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443430&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603230 440074607 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903674 Oc1ccc2c3C(Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2 BGOOMSGEXIBXHQ-UHFFFAOYSA-N 443432 Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]ethoxy}phenyl)-7- (trifluoromethyl)-5H- [1]benzopyrano[4,3- c]quinolin-2-ol::US10654866, Example 2::US11117902, Example 2::US11634426, Example 2 Estrogen receptor [Y537S] 6.78 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443432&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559732 440074609 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903676 Oc1ccc2c3[C@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m1/s1 BGOOMSGEXIBXHQ-HHHXNRCGSA-N 443433 US10654866, Example 2A::US11117902, Example 2B::US11634426, Example 2A Estrogen receptor [Y537S] 7.92 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443433&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603269 440074610 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903678 Oc1ccc2c3[C@@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m0/s1 BGOOMSGEXIBXHQ-MHZLTWQESA-N 443434 US10654866, Example 2B::US11117902, Example 2A::US11634426, Example 2B Estrogen receptor [Y537S] 294 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443434&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603270 440074611 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903680 Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2 HPRZXPUOMAQVBB-UHFFFAOYSA-N 443435 US10654866, Example 3::US10654866, Example 3A::US11117902, Example 3::US11634426, Example 3 Estrogen receptor [Y537S] 6.69 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443435&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559736 440074612 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903682 Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2 HPRZXPUOMAQVBB-UHFFFAOYSA-N 443435 US10654866, Example 3::US10654866, Example 3A::US11117902, Example 3::US11634426, Example 3 Estrogen receptor [Y537S] 27.2 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443435&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559736 440074612 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903684 Oc1ccc2c3[C@@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1 HPRZXPUOMAQVBB-NDEPHWFRSA-N 443449 US10654866, Example 3B::US11117902, Example 3A::US11634426, Example 3B Estrogen receptor [Y537S] 2.79 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443449&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603325 440074625 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903686 Oc1ccc2c3C(Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2 WPFXKSQRNMAJGV-UHFFFAOYSA-N 443450 US10654866, Example 4::US11117902, Example 4::US11634426, Example 4 Estrogen receptor [Y537S] 12.1 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443450&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559734 440074626 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903688 Oc1ccc2c3[C@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1 WPFXKSQRNMAJGV-HHHXNRCGSA-N 443437 US10654866, Example 4A::US11117902, Example 4B::US11634426, Example 4A Estrogen receptor [Y537S] 55.0 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443437&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603225 440074613 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903690 Oc1ccc2c3[C@@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1 WPFXKSQRNMAJGV-MHZLTWQESA-N 443444 US10654866, Example 4B::US11117902, Example 4A::US11634426, Example 4B Estrogen receptor [Y537S] 2.34 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443444&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603327 440074620 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903692 Oc1ccc2c3C(Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2 OGEAHDJGRDNLQY-UHFFFAOYSA-N 443438 US10654866, Example 5::US11117902, Example 5::US11634426, Example 5 Estrogen receptor [Y537S] 19.5 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443438&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559737 440074614 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903694 Oc1ccc2c3[C@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m1/s1 OGEAHDJGRDNLQY-MUUNZHRXSA-N 443445 US10654866, Example 5A::US11117902, Example 5B::US11634426, Example 5A Estrogen receptor [Y537S] 81.2 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443445&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603271 440074621 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903696 Oc1ccc2c3[C@@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1 OGEAHDJGRDNLQY-NDEPHWFRSA-N 443446 US10654866, Example 5B::US11117902, Example 5A::US11634426, Example 5B Estrogen receptor [Y537S] 6.56 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443446&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603235 440074622 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903698 Oc1ccc2c3C(Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2 UQBGEQPSMYFQHH-UHFFFAOYSA-N 443439 US10654866, Example 6::US11117902, Example 6::US11634426, Example 6 Estrogen receptor [Y537S] 15.8 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443439&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559733 440074615 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903700 Oc1ccc2c3[C@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1 UQBGEQPSMYFQHH-HHHXNRCGSA-N 443447 US10654866, Example 6A::US11117902, Example 6B::US11634426, Example 6A Estrogen receptor [Y537S] 46.0 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443447&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603258 440074623 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903702 Oc1ccc2c3[C@@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1 UQBGEQPSMYFQHH-MHZLTWQESA-N 443448 US10654866, Example 6B::US11117902, Example 6A::US11634426, Example 6B Estrogen receptor [Y537S] 5.71 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443448&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603255 440074624 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903704 Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1 InChI=1S/C29H27FN2O3/c1-18-2-8-23-25-15-31-26-13-21(33)5-9-24(26)28(25)29(35-27(23)12-18)20-3-6-22(7-4-20)34-11-10-32-16-19(14-30)17-32/h2-9,12-13,15,19,29,33H,10-11,14,16-17H2,1H3 DRPASBVXQUEVRW-UHFFFAOYSA-N 443440 US10654866, Example 7::US11634426, Example 7 Estrogen receptor [Y537S] 8.55 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443440&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559747 440074616 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903706 Cc1cccc-2c1OC(c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3 MKEHACYTGGCYPQ-UHFFFAOYSA-N 443441 US10654866, Example 8::US11117902, Example 8::US11634426, Example 8 Estrogen receptor [Y537S] 11.4 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443441&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559740 440074617 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903708 Cc1cccc-2c1O[C@@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m0/s1 MKEHACYTGGCYPQ-LJAQVGFWSA-N 443442 US10654866, Example 8A::US11117902, Example 8A::US11634426, Example 8B Estrogen receptor [Y537S] 66.9 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443442&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603236 440074618 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 903710 Cc1cccc-2c1O[C@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m1/s1 MKEHACYTGGCYPQ-GDLZYMKVSA-N 443443 US10654866, Example 8B::US11117902, Example 8B::US11634426, Example 8A Estrogen receptor [Y537S] 5.44 US Patent 10.7270/Q2D50R05 aid1804422 US10654866 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443443&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603261 440074619 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097171 Oc1ccc2c3C(Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2 UVBQMXOKKDCBJN-UHFFFAOYSA-N 443428 Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol::US10654866, Example 1::US11117902, Example 1::US11634426, Example 1 Estrogen receptor [Y537S] 5.80 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443428&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559745 440074605 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097173 Oc1ccc2c3[C@@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m0/s1 UVBQMXOKKDCBJN-NDEPHWFRSA-N 443430 US10654866, Example 1B::US11117902, Example 1A::US11634426, Example 1B Estrogen receptor [Y537S] 57.2 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443430&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603230 440074607 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097175 Oc1ccc2c3[C@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m1/s1 UVBQMXOKKDCBJN-MUUNZHRXSA-N 443429 US10654866, Example 1A::US11117902, Example 1B::US11634426, Example 1A Estrogen receptor [Y537S] 2.79 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443429&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603228 440074606 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097177 Oc1ccc2c3C(Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2 BGOOMSGEXIBXHQ-UHFFFAOYSA-N 443432 Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]ethoxy}phenyl)-7- (trifluoromethyl)-5H- [1]benzopyrano[4,3- c]quinolin-2-ol::US10654866, Example 2::US11117902, Example 2::US11634426, Example 2 Estrogen receptor [Y537S] 6.78 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443432&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559732 440074609 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097179 Oc1ccc2c3[C@@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m0/s1 BGOOMSGEXIBXHQ-MHZLTWQESA-N 443434 US10654866, Example 2B::US11117902, Example 2A::US11634426, Example 2B Estrogen receptor [Y537S] 7.92 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443434&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603270 440074611 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097181 Oc1ccc2c3[C@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m1/s1 BGOOMSGEXIBXHQ-HHHXNRCGSA-N 443433 US10654866, Example 2A::US11117902, Example 2B::US11634426, Example 2A Estrogen receptor [Y537S] 294 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443433&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603269 440074610 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097183 Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2 HPRZXPUOMAQVBB-UHFFFAOYSA-N 443435 US10654866, Example 3::US10654866, Example 3A::US11117902, Example 3::US11634426, Example 3 Estrogen receptor [Y537S] 6.69 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443435&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559736 440074612 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097185 Oc1ccc2c3[C@@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1 HPRZXPUOMAQVBB-NDEPHWFRSA-N 443449 US10654866, Example 3B::US11117902, Example 3A::US11634426, Example 3B Estrogen receptor [Y537S] 27.2 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443449&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603325 440074625 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097187 Oc1ccc2c3[C@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m1/s1 HPRZXPUOMAQVBB-MUUNZHRXSA-N 518821 US11117902, Example 3B::US11634426, Example 3A Estrogen receptor [Y537S] 2.79 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518821&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603260 461604836 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097189 Oc1ccc2c3C(Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2 WPFXKSQRNMAJGV-UHFFFAOYSA-N 443450 US10654866, Example 4::US11117902, Example 4::US11634426, Example 4 Estrogen receptor [Y537S] 12.1 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443450&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559734 440074626 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097191 Oc1ccc2c3[C@@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1 WPFXKSQRNMAJGV-MHZLTWQESA-N 443444 US10654866, Example 4B::US11117902, Example 4A::US11634426, Example 4B Estrogen receptor [Y537S] 55.0 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443444&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603327 440074620 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097193 Oc1ccc2c3[C@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1 WPFXKSQRNMAJGV-HHHXNRCGSA-N 443437 US10654866, Example 4A::US11117902, Example 4B::US11634426, Example 4A Estrogen receptor [Y537S] 2.34 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443437&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603225 440074613 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097195 Oc1ccc2c3C(Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2 OGEAHDJGRDNLQY-UHFFFAOYSA-N 443438 US10654866, Example 5::US11117902, Example 5::US11634426, Example 5 Estrogen receptor [Y537S] 19.5 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443438&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559737 440074614 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097197 Oc1ccc2c3[C@@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1 OGEAHDJGRDNLQY-NDEPHWFRSA-N 443446 US10654866, Example 5B::US11117902, Example 5A::US11634426, Example 5B Estrogen receptor [Y537S] 81.2 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443446&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603235 440074622 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097199 Oc1ccc2c3[C@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m1/s1 OGEAHDJGRDNLQY-MUUNZHRXSA-N 443445 US10654866, Example 5A::US11117902, Example 5B::US11634426, Example 5A Estrogen receptor [Y537S] 6.56 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443445&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603271 440074621 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097201 Oc1ccc2c3C(Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2 UQBGEQPSMYFQHH-UHFFFAOYSA-N 443439 US10654866, Example 6::US11117902, Example 6::US11634426, Example 6 Estrogen receptor [Y537S] 15.8 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443439&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559733 440074615 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097203 Oc1ccc2c3[C@@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1 UQBGEQPSMYFQHH-MHZLTWQESA-N 443448 US10654866, Example 6B::US11117902, Example 6A::US11634426, Example 6B Estrogen receptor [Y537S] 46.0 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443448&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603255 440074624 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097205 Oc1ccc2c3[C@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1 UQBGEQPSMYFQHH-HHHXNRCGSA-N 443447 US10654866, Example 6A::US11117902, Example 6B::US11634426, Example 6A Estrogen receptor [Y537S] 5.71 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443447&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603258 440074623 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097207 Oc1ccc2c(C(=O)c3ccc(OCCN4CC(CF)C4)cc3)c(cnc2c1)-c1cccc(c1F)C(F)(F)F InChI=1S/C29H23F5N2O3/c30-13-17-15-36(16-17)10-11-39-20-7-4-18(5-8-20)28(38)26-22-9-6-19(37)12-25(22)35-14-23(26)21-2-1-3-24(27(21)31)29(32,33)34/h1-9,12,14,17,37H,10-11,13,15-16H2 HCRKEDZVGNVRNR-UHFFFAOYSA-N 518852 US11117902, Example 7 Estrogen receptor [Y537S] 8.55 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518852&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603326 461604867 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097209 Cc1cccc-2c1OC(c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3 MKEHACYTGGCYPQ-UHFFFAOYSA-N 443441 US10654866, Example 8::US11117902, Example 8::US11634426, Example 8 Estrogen receptor [Y537S] 11.4 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443441&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559740 440074617 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097211 Cc1cccc-2c1O[C@@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m0/s1 MKEHACYTGGCYPQ-LJAQVGFWSA-N 443442 US10654866, Example 8A::US11117902, Example 8A::US11634426, Example 8B Estrogen receptor [Y537S] 66.9 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443442&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603236 440074618 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1097213 Cc1cccc-2c1O[C@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m1/s1 MKEHACYTGGCYPQ-GDLZYMKVSA-N 443443 US10654866, Example 8B::US11117902, Example 8B::US11634426, Example 8A Estrogen receptor [Y537S] 5.44 US Patent 10.7270/Q22B926M aid1805955 US11117902 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443443&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603261 440074619 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273591 Oc1ccc2c3C(Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2 UVBQMXOKKDCBJN-UHFFFAOYSA-N 443428 Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol::US10654866, Example 1::US11117902, Example 1::US11634426, Example 1 Estrogen receptor [Y537S] 5.80 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443428&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559745 440074605 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273593 Oc1ccc2c3[C@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m1/s1 UVBQMXOKKDCBJN-MUUNZHRXSA-N 443429 US10654866, Example 1A::US11117902, Example 1B::US11634426, Example 1A Estrogen receptor [Y537S] 57.2 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443429&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603228 440074606 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273595 Oc1ccc2c3[C@@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m0/s1 UVBQMXOKKDCBJN-NDEPHWFRSA-N 443430 US10654866, Example 1B::US11117902, Example 1A::US11634426, Example 1B Estrogen receptor [Y537S] 2.79 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443430&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603230 440074607 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273597 Oc1ccc2c3C(Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2 BGOOMSGEXIBXHQ-UHFFFAOYSA-N 443432 Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]ethoxy}phenyl)-7- (trifluoromethyl)-5H- [1]benzopyrano[4,3- c]quinolin-2-ol::US10654866, Example 2::US11117902, Example 2::US11634426, Example 2 Estrogen receptor [Y537S] 6.78 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443432&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559732 440074609 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273599 Oc1ccc2c3[C@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m1/s1 BGOOMSGEXIBXHQ-HHHXNRCGSA-N 443433 US10654866, Example 2A::US11117902, Example 2B::US11634426, Example 2A Estrogen receptor [Y537S] 7.92 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443433&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603269 440074610 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273601 Oc1ccc2c3[C@@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)10-11-37-20-7-4-18(5-8-20)27-26-22-9-6-19(36)12-25(22)34-14-23(26)21-2-1-3-24(28(21)38-27)29(31,32)33/h1-9,12,14,17,27,36H,10-11,13,15-16H2/t27-/m0/s1 BGOOMSGEXIBXHQ-MHZLTWQESA-N 443434 US10654866, Example 2B::US11117902, Example 2A::US11634426, Example 2B Estrogen receptor [Y537S] 294 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443434&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603270 440074611 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273603 Oc1ccc2c3C(Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2 HPRZXPUOMAQVBB-UHFFFAOYSA-N 443435 US10654866, Example 3::US10654866, Example 3A::US11117902, Example 3::US11634426, Example 3 Estrogen receptor [Y537S] 6.69 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443435&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559736 440074612 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273605 Oc1ccc2c3[C@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m1/s1 HPRZXPUOMAQVBB-MUUNZHRXSA-N 518821 US11117902, Example 3B::US11634426, Example 3A Estrogen receptor [Y537S] 27.2 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518821&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603260 461604836 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273607 Oc1ccc2c3[C@@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-19-3-7-22-24-14-31-25-12-20(33)4-8-23(25)27(24)28(35-26(22)11-19)18-1-5-21(6-2-18)34-10-9-32-15-17(13-30)16-32/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1 HPRZXPUOMAQVBB-NDEPHWFRSA-N 443449 US10654866, Example 3B::US11117902, Example 3A::US11634426, Example 3B Estrogen receptor [Y537S] 2.79 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443449&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603325 440074625 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273609 Oc1ccc2c3C(Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2 WPFXKSQRNMAJGV-UHFFFAOYSA-N 443450 US10654866, Example 4::US11117902, Example 4::US11634426, Example 4 Estrogen receptor [Y537S] 12.1 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443450&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559734 440074626 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273611 Oc1ccc2c3[C@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1 WPFXKSQRNMAJGV-HHHXNRCGSA-N 443437 US10654866, Example 4A::US11117902, Example 4B::US11634426, Example 4A Estrogen receptor [Y537S] 55.0 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443437&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603225 440074613 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273613 Oc1ccc2c3[C@@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24ClFN2O3/c29-24-3-1-2-21-23-14-31-25-12-19(33)6-9-22(25)26(23)27(35-28(21)24)18-4-7-20(8-5-18)34-11-10-32-15-17(13-30)16-32/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1 WPFXKSQRNMAJGV-MHZLTWQESA-N 443444 US10654866, Example 4B::US11117902, Example 4A::US11634426, Example 4B Estrogen receptor [Y537S] 2.34 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443444&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603327 440074620 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273615 Oc1ccc2c3C(Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2 OGEAHDJGRDNLQY-UHFFFAOYSA-N 443438 US10654866, Example 5::US11117902, Example 5::US11634426, Example 5 Estrogen receptor [Y537S] 19.5 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443438&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559737 440074614 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273617 Oc1ccc2c3[C@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m1/s1 OGEAHDJGRDNLQY-MUUNZHRXSA-N 443445 US10654866, Example 5A::US11117902, Example 5B::US11634426, Example 5A Estrogen receptor [Y537S] 81.2 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443445&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603271 440074621 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273619 Oc1ccc2c3[C@@H](Oc4cc(F)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)9-10-34-21-5-1-18(2-6-21)28-27-23-8-4-20(33)12-25(23)31-14-24(27)22-7-3-19(30)11-26(22)35-28/h1-8,11-12,14,17,28,33H,9-10,13,15-16H2/t28-/m0/s1 OGEAHDJGRDNLQY-NDEPHWFRSA-N 443446 US10654866, Example 5B::US11117902, Example 5A::US11634426, Example 5B Estrogen receptor [Y537S] 6.56 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443446&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603235 440074622 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273621 Oc1ccc2c3C(Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2 UQBGEQPSMYFQHH-UHFFFAOYSA-N 443439 US10654866, Example 6::US11117902, Example 6::US11634426, Example 6 Estrogen receptor [Y537S] 15.8 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443439&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559733 440074615 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273623 Oc1ccc2c3[C@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m1/s1 UQBGEQPSMYFQHH-HHHXNRCGSA-N 443447 US10654866, Example 6A::US11117902, Example 6B::US11634426, Example 6A Estrogen receptor [Y537S] 46.0 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443447&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603258 440074623 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273625 Oc1ccc2c3[C@@H](Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 InChI=1S/C28H24F2N2O3/c29-13-17-15-32(16-17)10-11-34-20-7-4-18(5-8-20)27-26-22-9-6-19(33)12-25(22)31-14-23(26)21-2-1-3-24(30)28(21)35-27/h1-9,12,14,17,27,33H,10-11,13,15-16H2/t27-/m0/s1 UQBGEQPSMYFQHH-MHZLTWQESA-N 443448 US10654866, Example 6B::US11117902, Example 6A::US11634426, Example 6B Estrogen receptor [Y537S] 5.71 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443448&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603255 440074624 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273627 Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1 InChI=1S/C29H27FN2O3/c1-18-2-8-23-25-15-31-26-13-21(33)5-9-24(26)28(25)29(35-27(23)12-18)20-3-6-22(7-4-20)34-11-10-32-16-19(14-30)17-32/h2-9,12-13,15,19,29,33H,10-11,14,16-17H2,1H3 DRPASBVXQUEVRW-UHFFFAOYSA-N 443440 US10654866, Example 7::US11634426, Example 7 Estrogen receptor [Y537S] 8.55 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443440&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559747 440074616 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273629 Cc1cccc-2c1OC(c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3 MKEHACYTGGCYPQ-UHFFFAOYSA-N 443441 US10654866, Example 8::US11117902, Example 8::US11634426, Example 8 Estrogen receptor [Y537S] 11.4 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443441&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146559740 440074617 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273631 Cc1cccc-2c1O[C@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m1/s1 MKEHACYTGGCYPQ-GDLZYMKVSA-N 443443 US10654866, Example 8B::US11117902, Example 8B::US11634426, Example 8A Estrogen receptor [Y537S] 66.9 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443443&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603261 440074619 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7 1273633 Cc1cccc-2c1O[C@@H](c1ccc(OCCN3CC(CF)C3)cc1)c1c-2cnc2cc(O)ccc12 InChI=1S/C29H27FN2O3/c1-18-3-2-4-23-25-15-31-26-13-21(33)7-10-24(26)27(25)29(35-28(18)23)20-5-8-22(9-6-20)34-12-11-32-16-19(14-30)17-32/h2-10,13,15,19,29,33H,11-12,14,16-17H2,1H3/t29-/m0/s1 MKEHACYTGGCYPQ-LJAQVGFWSA-N 443442 US10654866, Example 8A::US11117902, Example 8A::US11634426, Example 8B Estrogen receptor [Y537S] 5.44 US Patent 10.7270/Q2JM2FKJ US11634426 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=443442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=419&target=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=443442&enzyme=Estrogen+receptor+%5BY537S%5D&column=ki&startPg=0&Increment=50&submit=Search 146603236 440074618 1 MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV 1ERE,1ERR,1HCP,1HCQ,1ZKY,2B1V,2B1Z,2B23,2FAI,2G44,2G5O,2OCF,2OUZ,2P15,2Q6J,2QA6,2QA8,2QAB,2QGT,2QGW,2QH6,2QR9,2QSE,2QXM,2QZO,2YJA,3DT3,3HLV,3HM1,3L03,3OS8,3OS9,3OSA,3Q95,3UU7,3UUA,3UUD,4AA6,4IU7,4IUI,4IV2,4IV4,4IVW,4IVY,4IW6,4IW8,4IWC,4IWF,4MG5,4MG6,4MG7,4MG8,4MG9,4MGA,4MGB,4MGC,4MGD,4PP6,4PPP,4PPS,4TUZ,4TV1,4ZN7,4ZN9,4ZNH,4ZNS,4ZNT,4ZNU,4ZNV,4ZNW,5DI7,5DID,5DIE,5DIG,5DK9,5DKB,5DKE,5DKG,5DKS,5DL4,5DLR,5DMC,5DMF,5DP0,5DRJ,5DRM,5DTV,5DU5,5DUE,5DUG,5DUH,5DVS,5DVV,5DWE,5DWG,5DWI,5DWJ,5DX3,5DXB,5DXE,5DXG,5DXK,5DXM,5DXP,5DXQ,5DXR,5DY8,5DYB,5DYD,5DZ0,5DZ1,5DZ3,5DZH,5DZI,5E0W,5E0X,5E14,5E15,5E19,5E1C,5EGV,5EHJ,5EI1,5EIT,5GS4,5GTR,5HYR,5JMM,5KCC,5KCD,5KCE,5KCF,5KCT,5KCU,5KCW,5KD9,5KR9,5KRA,5KRC,5KRF,5KRH,5KRI,5KRJ,5KRK,5KRL,5KRM,5KRO,5TLD,5TLF,5TLG,5TLL,5TLM,5TLO,5TLP,5TLT,5TLU,5TLV,5TLX,5TLY,5TM1,5TM2,5TM3,5TM4,5TM5,5TM6,5TM7,5TM8,5TM9,5TML,5TMM,5TMO,5TMQ,5TMR,5TMS,5TMT,5TMU,5TMV,5TMW,5TMZ,5TN1,5TN3,5TN4,5TN5,5TN6,5TN7,5TN8,5U2B,5U2D,5WGD,5WGQ,6CBZ,6CZN,6D0F,6PIT,7JHD,7RKE,7RNM,7SFO,7T2X,7Y8F,7Y8G,8EV1,8EV2 Estrogen receptor ESR1_HUMAN P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7