BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 265269 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C23H26N8/c1-2-4-16(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-21-6-5-17(13-26-21)30-11-9-24-10-12-30/h5-8,13-16,24H,1-4,9-12H2,(H,26,27,28,29) MCPPMOSBWNMSOA-UHFFFAOYSA-N 50001584 CHEMBL3237442::US8841312, 1 Cyclin-dependent kinase 6 Homo sapiens 4.4 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001584&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 24V 4TTH 44132585 103916014 CHEMBL3237442 ZINC13728944 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265270 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C24H28N8/c1-30-10-12-31(13-11-30)18-6-7-22(26-14-18)28-24-27-15-20-19-8-9-25-16-21(19)32(23(20)29-24)17-4-2-3-5-17/h6-9,14-17H,2-5,10-13H2,1H3,(H,26,27,28,29) IJPHYTNUHVHWHD-UHFFFAOYSA-N 132260 US8841312, 2 Cyclin-dependent kinase 6 Homo sapiens 10 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132260&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299898 242055227 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265271 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 InChI=1S/C24H27N7/c1-2-4-19(3-1)31-22-16-26-10-9-20(22)21-15-27-24(29-23(21)31)28-17-5-7-18(8-6-17)30-13-11-25-12-14-30/h5-10,15-16,19,25H,1-4,11-14H2,(H,27,28,29) AKXCIKNLMOJVRG-UHFFFAOYSA-N 132261 US8841312, 3 Cyclin-dependent kinase 6 Homo sapiens 2.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132261&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299744 242055228 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265272 C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H27N9/c1-15-14-31(11-10-25-15)21-7-6-20(29-30-21)27-23-26-12-18-17-8-9-24-13-19(17)32(22(18)28-23)16-4-2-3-5-16/h6-9,12-13,15-16,25H,2-5,10-11,14H2,1H3,(H,26,27,28,29)/t15-/m1/s1 ZJASKMZRNIQJAD-OAHLLOKOSA-N 132262 US8841312, 4 Cyclin-dependent kinase 6 Homo sapiens 11.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132262&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299862 242055229 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265273 Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1 InChI=1S/C24H28N8/c1-16-12-17(13-27-22(16)31-10-8-25-9-11-31)29-24-28-14-20-19-6-7-26-15-21(19)32(23(20)30-24)18-4-2-3-5-18/h6-7,12-15,18,25H,2-5,8-11H2,1H3,(H,28,29,30) MSKGFMBSNBBHMB-UHFFFAOYSA-N 132263 US8841312, 5 Cyclin-dependent kinase 6 Homo sapiens 4.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132263&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299874 242055230 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265274 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 InChI=1S/C22H25N9/c1-2-4-15(3-1)31-18-14-24-8-7-16(18)17-13-25-22(27-21(17)31)26-19-5-6-20(29-28-19)30-11-9-23-10-12-30/h5-8,13-15,23H,1-4,9-12H2,(H,25,26,27,28) KLYIOUNPTCQBFR-UHFFFAOYSA-N 132264 US8841312, 6 Cyclin-dependent kinase 6 Homo sapiens 6.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132264&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299921 242055231 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265275 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nc3)N3CCNCC3)nc12 InChI=1S/C23H26N8/c1-2-4-17(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-16-5-6-21(26-13-16)30-11-9-24-10-12-30/h5-8,13-15,17,24H,1-4,9-12H2,(H,27,28,29) QDFRMUUVZQGYCN-UHFFFAOYSA-N 132265 US8841312, 7 Cyclin-dependent kinase 6 Homo sapiens 1.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132265&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299847 242055232 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265276 C1CCC(C1)n1c2cnccc2c2cnc(Nc3cnc(nc3)N3CCNCC3)nc12 InChI=1S/C22H25N9/c1-2-4-16(3-1)31-19-14-24-6-5-17(19)18-13-25-21(29-20(18)31)28-15-11-26-22(27-12-15)30-9-7-23-8-10-30/h5-6,11-14,16,23H,1-4,7-10H2,(H,25,28,29) PMMUWIAESYJLQU-UHFFFAOYSA-N 132266 US8841312, 8 Cyclin-dependent kinase 6 Homo sapiens 1.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132266&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 42642089 242055233 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265277 C[C@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H27N9/c1-15-14-31(11-10-25-15)21-7-6-20(29-30-21)27-23-26-12-18-17-8-9-24-13-19(17)32(22(18)28-23)16-4-2-3-5-16/h6-9,12-13,15-16,25H,2-5,10-11,14H2,1H3,(H,26,27,28,29)/t15-/m0/s1 ZJASKMZRNIQJAD-HNNXBMFYSA-N 132267 US8841312, 9 Cyclin-dependent kinase 6 Homo sapiens 19.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132267&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299687 242055234 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265278 NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C24H28N8/c25-16-8-11-31(12-9-16)18-5-6-22(27-13-18)29-24-28-14-20-19-7-10-26-15-21(19)32(23(20)30-24)17-3-1-2-4-17/h5-7,10,13-17H,1-4,8-9,11-12,25H2,(H,27,28,29,30) RZHDOGFDNMHBOL-UHFFFAOYSA-N 132269 US8841312, 11 Cyclin-dependent kinase 6 Homo sapiens 10 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132269&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299759 242055236 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265279 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C25H31N9/c1-32(2)17-10-13-33(14-11-17)23-8-7-22(30-31-23)28-25-27-15-20-19-9-12-26-16-21(19)34(24(20)29-25)18-5-3-4-6-18/h7-9,12,15-18H,3-6,10-11,13-14H2,1-2H3,(H,27,28,29,30) ZQHZICOJSNIGEO-UHFFFAOYSA-N 132271 US8841312, 13 Cyclin-dependent kinase 6 Homo sapiens 2.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132271&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299604 242055238 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265280 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(-c2ccccc2)c2cnccc32)nc1 InChI=1S/C24H22N8/c1-2-4-17(5-3-1)32-21-16-26-9-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-10-25-11-13-31/h1-9,14-16,25H,10-13H2,(H,27,28,29,30) DZWLTXLJZHDQOP-UHFFFAOYSA-N 132272 US8841312, 14 Cyclin-dependent kinase 6 Homo sapiens 8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132272&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300137 242055239 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265281 Fc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C24H21FN8/c25-16-1-3-17(4-2-16)33-21-15-27-8-7-19(21)20-14-29-24(31-23(20)33)30-22-6-5-18(13-28-22)32-11-9-26-10-12-32/h1-8,13-15,26H,9-12H2,(H,28,29,30,31) UQVFTDIMDMBMCP-UHFFFAOYSA-N 132273 US8841312, 15 Cyclin-dependent kinase 6 Homo sapiens 13 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132273&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299889 242055240 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265282 COc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C25H24N8O/c1-34-19-5-2-17(3-6-19)33-22-16-27-9-8-20(22)21-15-29-25(31-24(21)33)30-23-7-4-18(14-28-23)32-12-10-26-11-13-32/h2-9,14-16,26H,10-13H2,1H3,(H,28,29,30,31) WNBOZMLWGXPGLO-UHFFFAOYSA-N 132274 US8841312, 16 Cyclin-dependent kinase 6 Homo sapiens 21 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132274&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300153 242055241 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265283 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(-c2ccccc2)c2cnccc32)cc1 InChI=1S/C25H23N7/c1-2-4-20(5-3-1)32-23-17-27-11-10-21(23)22-16-28-25(30-24(22)32)29-18-6-8-19(9-7-18)31-14-12-26-13-15-31/h1-11,16-17,26H,12-15H2,(H,28,29,30) NMGQIPHNZLRCPJ-UHFFFAOYSA-N 132275 US8841312, 17 Cyclin-dependent kinase 6 Homo sapiens 0.36 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132275&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300207 242055242 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265284 O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C22H24N8O/c31-15-8-10-29(13-15)20-6-5-19(27-28-20)25-22-24-11-17-16-7-9-23-12-18(16)30(21(17)26-22)14-3-1-2-4-14/h5-7,9,11-12,14-15,31H,1-4,8,10,13H2,(H,24,25,26,27)/t15-/m1/s1 BWIZOFRKIJFPNB-OAHLLOKOSA-N 132276 US8841312, 18 Cyclin-dependent kinase 6 Homo sapiens 1.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132276&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299861 242055243 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265285 O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C22H24N8O/c31-15-8-10-29(13-15)20-6-5-19(27-28-20)25-22-24-11-17-16-7-9-23-12-18(16)30(21(17)26-22)14-3-1-2-4-14/h5-7,9,11-12,14-15,31H,1-4,8,10,13H2,(H,24,25,26,27)/t15-/m0/s1 BWIZOFRKIJFPNB-HNNXBMFYSA-N 132277 US8841312, 19 Cyclin-dependent kinase 6 Homo sapiens 10 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132277&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300094 242055244 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265286 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCOCC2)c2cnccc32)nc1 InChI=1S/C23H26N8O/c1-2-21(26-13-17(1)30-9-7-24-8-10-30)28-23-27-14-19-18-3-6-25-15-20(18)31(22(19)29-23)16-4-11-32-12-5-16/h1-3,6,13-16,24H,4-5,7-12H2,(H,26,27,28,29) QKFMIXAVODWZLI-UHFFFAOYSA-N 132278 US8841312, 20 Cyclin-dependent kinase 6 Homo sapiens 57 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132278&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299630 242055245 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265287 C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 InChI=1S/C26H30N6/c1-2-6-21(7-3-1)32-24-9-5-4-8-22(24)23-18-28-26(30-25(23)32)29-19-10-12-20(13-11-19)31-16-14-27-15-17-31/h4-5,8-13,18,21,27H,1-3,6-7,14-17H2,(H,28,29,30) WJVUVSWJHMODPQ-UHFFFAOYSA-N 132279 US8841312, 21 Cyclin-dependent kinase 6 Homo sapiens 0.41 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132279&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299967 242055246 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265288 C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C25H29N7/c1-2-6-18(7-3-1)32-22-9-5-4-8-20(22)21-17-28-25(30-24(21)32)29-23-11-10-19(16-27-23)31-14-12-26-13-15-31/h4-5,8-11,16-18,26H,1-3,6-7,12-15H2,(H,27,28,29,30) ROVFHHODJNANCC-UHFFFAOYSA-N 132280 US8841312, 22 Cyclin-dependent kinase 6 Homo sapiens 2.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132280&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299658 242055247 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265289 C1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C24H28N8/c1-2-4-17(5-3-1)32-21-16-26-9-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-10-25-11-13-31/h6-9,14-17,25H,1-5,10-13H2,(H,27,28,29,30) UKUVHVSOTZPZBW-UHFFFAOYSA-N 50001536 CHEMBL3237451::US8841312, 23 Cyclin-dependent kinase 6 Homo sapiens 13.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001536&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299868 242055956 CHEMBL3237451 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265290 C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C25H28N8/c1-2-17-11-16(1)12-21(17)33-22-15-27-6-5-19(22)20-14-29-25(31-24(20)33)30-23-4-3-18(13-28-23)32-9-7-26-8-10-32/h3-6,13-17,21,26H,1-2,7-12H2,(H,28,29,30,31) BURBSRHEPGFKHA-UHFFFAOYSA-N 132281 US8841312, 24 Cyclin-dependent kinase 6 Homo sapiens 5.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132281&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299701 242055248 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265291 C1Cc2ccccc2C1n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C27H26N8/c1-2-4-20-18(3-1)5-7-23(20)35-24-17-29-10-9-21(24)22-16-31-27(33-26(22)35)32-25-8-6-19(15-30-25)34-13-11-28-12-14-34/h1-4,6,8-10,15-17,23,28H,5,7,11-14H2,(H,30,31,32,33) GGRSBRWNHVOEPC-UHFFFAOYSA-N 132282 US8841312, 25 Cyclin-dependent kinase 6 Homo sapiens 38 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132282&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300208 242055249 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265292 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(c2cnccc32)C23CC4CC(CC(C4)C2)C3)nc1 InChI=1S/C28H32N8/c1-2-25(31-15-21(1)35-7-5-29-6-8-35)33-27-32-16-23-22-3-4-30-17-24(22)36(26(23)34-27)28-12-18-9-19(13-28)11-20(10-18)14-28/h1-4,15-20,29H,5-14H2,(H,31,32,33,34) DSNHCXNKKZEERJ-UHFFFAOYSA-N 132283 US8841312, 26 Cyclin-dependent kinase 6 Homo sapiens 3.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132283&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300092 242055250 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265293 CC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C22H26N8/c1-22(2,3)30-18-14-24-7-6-16(18)17-13-26-21(28-20(17)30)27-19-5-4-15(12-25-19)29-10-8-23-9-11-29/h4-7,12-14,23H,8-11H2,1-3H3,(H,25,26,27,28) VMVGVNIHPKFEIL-UHFFFAOYSA-N 132284 US8841312, 27 Cyclin-dependent kinase 6 Homo sapiens 7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132284&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300205 242055251 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265294 C[C@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C26H32N8/c1-18(19-5-3-2-4-6-19)34-23-17-28-10-9-21(23)22-16-30-26(32-25(22)34)31-24-8-7-20(15-29-24)33-13-11-27-12-14-33/h7-10,15-19,27H,2-6,11-14H2,1H3,(H,29,30,31,32)/t18-/m1/s1 KTAKVDASVPBVHO-GOSISDBHSA-N 132285 US8841312, 28 Cyclin-dependent kinase 6 Homo sapiens 61 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132285&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299643 242055252 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265295 C[C@@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C26H32N8/c1-18(19-5-3-2-4-6-19)34-23-17-28-10-9-21(23)22-16-30-26(32-25(22)34)31-24-8-7-20(15-29-24)33-13-11-27-12-14-33/h7-10,15-19,27H,2-6,11-14H2,1H3,(H,29,30,31,32)/t18-/m0/s1 KTAKVDASVPBVHO-SFHVURJKSA-N 132286 US8841312, 29 Cyclin-dependent kinase 6 Homo sapiens 5.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132286&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300044 242055253 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265296 C1CC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C22H24N8/c1-2-15(3-1)30-19-14-24-7-6-17(19)18-13-26-22(28-21(18)30)27-20-5-4-16(12-25-20)29-10-8-23-9-11-29/h4-7,12-15,23H,1-3,8-11H2,(H,25,26,27,28) XMLANQVRPNNKMS-UHFFFAOYSA-N 132287 US8841312, 30 Cyclin-dependent kinase 6 Homo sapiens 6.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132287&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300142 242055254 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265297 O[C@H]1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C24H28N8O/c33-18-4-1-16(2-5-18)32-21-15-26-8-7-19(21)20-14-28-24(30-23(20)32)29-22-6-3-17(13-27-22)31-11-9-25-10-12-31/h3,6-8,13-16,18,25,33H,1-2,4-5,9-12H2,(H,27,28,29,30)/t16?,18- XMWHZKQZVIMLTH-NREYKIJXSA-N 132288 US8841312, 31 Cyclin-dependent kinase 6 Homo sapiens 5.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132288&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300077 242055255 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265298 C(C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C25H30N8/c1-2-4-18(5-3-1)17-33-22-16-27-9-8-20(22)21-15-29-25(31-24(21)33)30-23-7-6-19(14-28-23)32-12-10-26-11-13-32/h6-9,14-16,18,26H,1-5,10-13,17H2,(H,28,29,30,31) FLELSIDTMCCIRQ-UHFFFAOYSA-N 132289 US8841312, 32 Cyclin-dependent kinase 6 Homo sapiens 30.4 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132289&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299738 242055256 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265299 CC1(CCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C23H26N8/c1-23(6-2-7-23)31-19-15-25-8-5-17(19)18-14-27-22(29-21(18)31)28-20-4-3-16(13-26-20)30-11-9-24-10-12-30/h3-5,8,13-15,24H,2,6-7,9-12H2,1H3,(H,26,27,28,29) RMYBOOZEFJJYAI-UHFFFAOYSA-N 132290 US8841312, 33 Cyclin-dependent kinase 6 Homo sapiens 8.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132290&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299648 242055257 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265300 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCCCCC2)c2cnccc32)nc1 InChI=1S/C25H30N8/c1-2-4-6-18(5-3-1)33-22-17-27-10-9-20(22)21-16-29-25(31-24(21)33)30-23-8-7-19(15-28-23)32-13-11-26-12-14-32/h7-10,15-18,26H,1-6,11-14H2,(H,28,29,30,31) ZUUXXQZUHHHBPS-UHFFFAOYSA-N 132291 US8841312, 34 Cyclin-dependent kinase 6 Homo sapiens 21 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132291&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300105 242055258 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265301 C1CCC(C1)n1c2ncccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C23H26N8/c1-2-5-16(4-1)31-21-18(6-3-9-25-21)19-15-27-23(29-22(19)31)28-20-8-7-17(14-26-20)30-12-10-24-11-13-30/h3,6-9,14-16,24H,1-2,4-5,10-13H2,(H,26,27,28,29) JXVCQGBDCQGWBV-UHFFFAOYSA-N 132292 US8841312, 35 Cyclin-dependent kinase 6 Homo sapiens 21 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132292&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300185 242055259 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265302 C1CCC(C1)n1c2ncccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 InChI=1S/C24H27N7/c1-2-5-19(4-1)31-22-20(6-3-11-26-22)21-16-27-24(29-23(21)31)28-17-7-9-18(10-8-17)30-14-12-25-13-15-30/h3,6-11,16,19,25H,1-2,4-5,12-15H2,(H,27,28,29) RHOCTZQICRQPCV-UHFFFAOYSA-N 132293 US8841312, 36 Cyclin-dependent kinase 6 Homo sapiens 4.4 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132293&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300214 242055260 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265303 C1CCC(C1)n1c2ccccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C24H27N7/c1-2-6-17(5-1)31-21-8-4-3-7-19(21)20-16-27-24(29-23(20)31)28-22-10-9-18(15-26-22)30-13-11-25-12-14-30/h3-4,7-10,15-17,25H,1-2,5-6,11-14H2,(H,26,27,28,29) HXNPDRQGWMHOBE-UHFFFAOYSA-N 132294 US8841312, 37 Cyclin-dependent kinase 6 Homo sapiens 1.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132294&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300168 242055261 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265304 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCOCC2)c2ccccc32)nc1 InChI=1S/C24H27N7O/c1-2-4-21-19(3-1)20-16-27-24(29-23(20)31(21)17-7-13-32-14-8-17)28-22-6-5-18(15-26-22)30-11-9-25-10-12-30/h1-6,15-17,25H,7-14H2,(H,26,27,28,29) VHWYHHQIYHLXIJ-UHFFFAOYSA-N 132295 US8841312, 38 Cyclin-dependent kinase 6 Homo sapiens 15.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132295&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300030 242055262 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265305 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCCCCC2)c2ccccc32)nc1 InChI=1S/C26H31N7/c1-2-4-8-19(7-3-1)33-23-10-6-5-9-21(23)22-18-29-26(31-25(22)33)30-24-12-11-20(17-28-24)32-15-13-27-14-16-32/h5-6,9-12,17-19,27H,1-4,7-8,13-16H2,(H,28,29,30,31) DLOAOZHQATYZNK-UHFFFAOYSA-N 132296 US8841312, 39 Cyclin-dependent kinase 6 Homo sapiens 3.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132296&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44132743 242055263 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265306 C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 InChI=1S/C26H29N7/c1-2-18-13-17(1)14-23(18)33-24-16-28-8-7-21(24)22-15-29-26(31-25(22)33)30-19-3-5-20(6-4-19)32-11-9-27-10-12-32/h3-8,15-18,23,27H,1-2,9-14H2,(H,29,30,31) RXSMWEYGRAHVQN-UHFFFAOYSA-N 132297 US8841312, 40 Cyclin-dependent kinase 6 Homo sapiens 2.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132297&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299888 242055264 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265307 N#Cc1ccc2c(c1)n(C1CCCC1)c1nc(Nc3ccc(cn3)N3CCNCC3)ncc21 InChI=1S/C25H26N8/c26-14-17-5-7-20-21-16-29-25(31-24(21)33(22(20)13-17)18-3-1-2-4-18)30-23-8-6-19(15-28-23)32-11-9-27-10-12-32/h5-8,13,15-16,18,27H,1-4,9-12H2,(H,28,29,30,31) MYNSISSWZNWEKP-UHFFFAOYSA-N 132298 US8841312, 41 Cyclin-dependent kinase 6 Homo sapiens 7.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132298&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299669 242055265 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265308 COc1cc2c(cn1)n(C1CCCC1)c1nc(Nc3ccc(cn3)N3CCNCC3)ncc21 InChI=1S/C24H28N8O/c1-33-22-12-18-19-14-28-24(29-21-7-6-17(13-26-21)31-10-8-25-9-11-31)30-23(19)32(20(18)15-27-22)16-4-2-3-5-16/h6-7,12-16,25H,2-5,8-11H2,1H3,(H,26,28,29,30) WEHVSGDBAMEZCL-UHFFFAOYSA-N 132299 US8841312, 42 Cyclin-dependent kinase 6 Homo sapiens 500 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132299&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299765 242055266 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265309 Oc1cc2c(cn1)n(C1CCCC1)c1nc(Nc3ccc(cn3)N3CCNCC3)ncc21 InChI=1S/C23H26N8O/c32-21-11-17-18-13-27-23(28-20-6-5-16(12-25-20)30-9-7-24-8-10-30)29-22(18)31(19(17)14-26-21)15-3-1-2-4-15/h5-6,11-15,24H,1-4,7-10H2,(H,26,32)(H,25,27,28,29) HYDOSWLWKXMOGK-UHFFFAOYSA-N 132300 US8841312, 43 Cyclin-dependent kinase 6 Homo sapiens 218 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132300&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299906 242055267 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265310 OCC1(CCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C24H28N8O/c33-16-24(6-1-2-7-24)32-20-15-26-8-5-18(20)19-14-28-23(30-22(19)32)29-21-4-3-17(13-27-21)31-11-9-25-10-12-31/h3-5,8,13-15,25,33H,1-2,6-7,9-12,16H2,(H,27,28,29,30) IMANTSACQRSZER-UHFFFAOYSA-N 132301 US8841312, 44 Cyclin-dependent kinase 6 Homo sapiens 25 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132301&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299783 242055268 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265311 CC(C)(CO)Cn1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C23H28N8O/c1-23(2,15-32)14-31-19-13-25-6-5-17(19)18-12-27-22(29-21(18)31)28-20-4-3-16(11-26-20)30-9-7-24-8-10-30/h3-6,11-13,24,32H,7-10,14-15H2,1-2H3,(H,26,27,28,29) WFAWAQUXUURRFW-UHFFFAOYSA-N 132302 US8841312, 45 Cyclin-dependent kinase 6 Homo sapiens 129 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132302&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299717 242055269 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265312 C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCOCC2)c2ccccc32)cc1 InChI=1S/C25H28N6O/c1-2-4-23-21(3-1)22-17-27-25(29-24(22)31(23)20-9-15-32-16-10-20)28-18-5-7-19(8-6-18)30-13-11-26-12-14-30/h1-8,17,20,26H,9-16H2,(H,27,28,29) XIDKPCVBCPPONE-UHFFFAOYSA-N 132303 US8841312, 46 Cyclin-dependent kinase 6 Homo sapiens 0.75 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132303&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300088 242055270 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265313 C1CCC(C1)n1c2ccccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 InChI=1S/C25H28N6/c1-2-6-20(5-1)31-23-8-4-3-7-21(23)22-17-27-25(29-24(22)31)28-18-9-11-19(12-10-18)30-15-13-26-14-16-30/h3-4,7-12,17,20,26H,1-2,5-6,13-16H2,(H,27,28,29) XEJXFSVXCFISJM-UHFFFAOYSA-N 132304 US8841312, 47 Cyclin-dependent kinase 6 Homo sapiens 3.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132304&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300070 242055271 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265314 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCCNCC3)nc12 InChI=1S/C24H28N8/c1-2-5-17(4-1)32-21-16-26-10-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-3-9-25-11-13-31/h6-8,10,14-17,25H,1-5,9,11-13H2,(H,27,28,29,30) JUQKGEXKBSXXHM-UHFFFAOYSA-N 132305 US8841312, 48 Cyclin-dependent kinase 6 Homo sapiens 5.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132305&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300009 242055272 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265315 O=C(N1CCNCC1)c1csc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)n1 InChI=1S/C22H24N8OS/c31-20(29-9-7-23-8-10-29)17-13-32-22(26-17)28-21-25-11-16-15-5-6-24-12-18(15)30(19(16)27-21)14-3-1-2-4-14/h5-6,11-14,23H,1-4,7-10H2,(H,25,26,27,28) FICIRDHVWSBGDI-UHFFFAOYSA-N 132306 US8841312, 49 Cyclin-dependent kinase 6 Homo sapiens 6.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132306&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299994 242055273 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265316 O=C(N1CCNCC1)c1cnc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)s1 InChI=1S/C22H24N8OS/c31-20(29-9-7-23-8-10-29)18-13-26-22(32-18)28-21-25-11-16-15-5-6-24-12-17(15)30(19(16)27-21)14-3-1-2-4-14/h5-6,11-14,23H,1-4,7-10H2,(H,25,26,27,28) JQOIYKPXKQECLH-UHFFFAOYSA-N 132307 US8841312, 50 Cyclin-dependent kinase 6 Homo sapiens 112 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132307&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299943 242055274 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265317 Cc1cc(cnc1Nc1ncc2c3ccncc3n(C3CCCC3)c2n1)N1CCNCC1 InChI=1S/C24H28N8/c1-16-12-18(31-10-8-25-9-11-31)13-27-22(16)29-24-28-14-20-19-6-7-26-15-21(19)32(23(20)30-24)17-4-2-3-5-17/h6-7,12-15,17,25H,2-5,8-11H2,1H3,(H,27,28,29,30) VUTNEOKLYIUETI-UHFFFAOYSA-N 132308 US8841312, 51 Cyclin-dependent kinase 6 Homo sapiens 406 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132308&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300064 242055275 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265318 COc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12 InChI=1S/C24H28N8O/c1-33-23-21-18(8-9-26-23)19-15-28-24(30-22(19)32(21)16-4-2-3-5-16)29-20-7-6-17(14-27-20)31-12-10-25-11-13-31/h6-9,14-16,25H,2-5,10-13H2,1H3,(H,27,28,29,30) VGTZAEIJCBVBJN-UHFFFAOYSA-N 132309 US8841312, 52 Cyclin-dependent kinase 6 Homo sapiens 22 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299722 242055276 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265319 O=c1[nH]ccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12 InChI=1S/C23H26N8O/c32-22-20-17(7-8-25-22)18-14-27-23(29-21(18)31(20)15-3-1-2-4-15)28-19-6-5-16(13-26-19)30-11-9-24-10-12-30/h5-8,13-15,24H,1-4,9-12H2,(H,25,32)(H,26,27,28,29) CYWGQHJAUWDZKC-UHFFFAOYSA-N 132310 US8841312, 53 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132310&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 76745510 242055277 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265320 Cc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12 InChI=1S/C24H28N8/c1-16-22-19(8-9-26-16)20-15-28-24(30-23(20)32(22)17-4-2-3-5-17)29-21-7-6-18(14-27-21)31-12-10-25-11-13-31/h6-9,14-15,17,25H,2-5,10-13H2,1H3,(H,27,28,29,30) FLNHSHVOGZEONH-UHFFFAOYSA-N 50001587 CHEMBL3237445::US8841312, 54 Cyclin-dependent kinase 6 Homo sapiens 47 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001587&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300068 103916017 CHEMBL3237445 ZINC12941886 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265321 CC1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C25H30N8/c1-17-2-4-18(5-3-17)33-22-16-27-9-8-20(22)21-15-29-25(31-24(21)33)30-23-7-6-19(14-28-23)32-12-10-26-11-13-32/h6-9,14-18,26H,2-5,10-13H2,1H3,(H,28,29,30,31) RKILQDBEPHSTGP-UHFFFAOYSA-N 50001537 CHEMBL3237702::US8841312, 55 Cyclin-dependent kinase 6 Homo sapiens 4.4 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001537&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299617 242055957 CHEMBL3237702 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265322 Fc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12 InChI=1S/C23H25FN8/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30) IEPYZPJZYINELK-UHFFFAOYSA-N 50001585 CHEMBL3237443::US8841312, 57 Cyclin-dependent kinase 6 Homo sapiens 17 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001585&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299836 103916015 CHEMBL3237443 ZINC13728939 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265323 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(N[C@@H]4CCNC4)cn3)nc12 InChI=1S/C23H26N8/c1-2-4-17(3-1)31-20-14-25-10-8-18(20)19-13-27-23(30-22(19)31)29-21-6-5-15(12-26-21)28-16-7-9-24-11-16/h5-6,8,10,12-14,16-17,24,28H,1-4,7,9,11H2,(H,26,27,29,30)/t16-/m1/s1 SMNBJOCPOYEKDE-MRXNPFEDSA-N 132317 US8841312, 63 Cyclin-dependent kinase 6 Homo sapiens 20 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132317&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300034 242055284 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265324 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(N[C@H]4CCNC4)cn3)nc12 InChI=1S/C23H26N8/c1-2-4-17(3-1)31-20-14-25-10-8-18(20)19-13-27-23(30-22(19)31)29-21-6-5-15(12-26-21)28-16-7-9-24-11-16/h5-6,8,10,12-14,16-17,24,28H,1-4,7,9,11H2,(H,26,27,29,30)/t16-/m0/s1 SMNBJOCPOYEKDE-INIZCTEOSA-N 132318 US8841312, 64 Cyclin-dependent kinase 6 Homo sapiens 24 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132318&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299882 242055285 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265325 O=S1(=O)CCC(C1)Nc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C23H25N7O2S/c31-33(32)10-8-16(14-33)27-15-5-6-21(25-11-15)28-23-26-12-19-18-7-9-24-13-20(18)30(22(19)29-23)17-3-1-2-4-17/h5-7,9,11-13,16-17,27H,1-4,8,10,14H2,(H,25,26,28,29) QYKOXFSITMBUDO-UHFFFAOYSA-N 132319 US8841312, 65 Cyclin-dependent kinase 6 Homo sapiens 24 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132319&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300151 242055286 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265326 O=S1(=O)CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C23H25N7O2S/c31-33(32)11-9-29(10-12-33)17-5-6-21(25-13-17)27-23-26-14-19-18-7-8-24-15-20(18)30(22(19)28-23)16-3-1-2-4-16/h5-8,13-16H,1-4,9-12H2,(H,25,26,27,28) HKVDMDVJPHFROE-UHFFFAOYSA-N 132320 US8841312, 66 Cyclin-dependent kinase 6 Homo sapiens 73 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132320&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299884 242055287 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265327 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(NC4CCNCC4)cn3)nc12 InChI=1S/C24H28N8/c1-2-4-18(3-1)32-21-15-26-12-9-19(21)20-14-28-24(31-23(20)32)30-22-6-5-17(13-27-22)29-16-7-10-25-11-8-16/h5-6,9,12-16,18,25,29H,1-4,7-8,10-11H2,(H,27,28,30,31) LCZLJATWTUPEBT-UHFFFAOYSA-N 132323 US8841312, 69 Cyclin-dependent kinase 6 Homo sapiens 31 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132323&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299682 242055290 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265328 CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C24H29N9/c1-25-16-9-12-32(13-10-16)22-7-6-21(30-31-22)28-24-27-14-19-18-8-11-26-15-20(18)33(23(19)29-24)17-4-2-3-5-17/h6-8,11,14-17,25H,2-5,9-10,12-13H2,1H3,(H,27,28,29,30) YQWSVHFHZUWHJT-UHFFFAOYSA-N 132331 US8841312, 77 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132331&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300213 242055298 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265329 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(N[C@@H]4CCNC4)nn3)nc12 InChI=1S/C22H25N9/c1-2-4-15(3-1)31-18-13-24-10-8-16(18)17-12-25-22(28-21(17)31)27-20-6-5-19(29-30-20)26-14-7-9-23-11-14/h5-6,8,10,12-15,23H,1-4,7,9,11H2,(H,26,29)(H,25,27,28,30)/t14-/m1/s1 NJQPWPCWSTUVSO-CQSZACIVSA-N 132345 US8841312, 91 Cyclin-dependent kinase 6 Homo sapiens 11.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132345&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300074 242055312 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265330 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(N[C@H]4CCNC4)nn3)nc12 InChI=1S/C22H25N9/c1-2-4-15(3-1)31-18-13-24-10-8-16(18)17-12-25-22(28-21(17)31)27-20-6-5-19(29-30-20)26-14-7-9-23-11-14/h5-6,8,10,12-15,23H,1-4,7,9,11H2,(H,26,29)(H,25,27,28,30)/t14-/m0/s1 NJQPWPCWSTUVSO-AWEZNQCLSA-N 132346 US8841312, 92 Cyclin-dependent kinase 6 Homo sapiens 15.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132346&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44132745 242055313 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265331 O=S1(=O)CCC(C1)Nc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C22H24N8O2S/c31-33(32)10-8-14(13-33)25-19-5-6-20(29-28-19)26-22-24-11-17-16-7-9-23-12-18(16)30(21(17)27-22)15-3-1-2-4-15/h5-7,9,11-12,14-15H,1-4,8,10,13H2,(H,25,28)(H,24,26,27,29) XWJNDQQXLCXSQR-UHFFFAOYSA-N 132347 US8841312, 93 Cyclin-dependent kinase 6 Homo sapiens 15.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132347&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299748 242055314 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265332 O=S1(=O)CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C22H24N8O2S/c31-33(32)11-9-29(10-12-33)20-6-5-19(27-28-20)25-22-24-13-17-16-7-8-23-14-18(16)30(21(17)26-22)15-3-1-2-4-15/h5-8,13-15H,1-4,9-12H2,(H,24,25,26,27) YTFXXQYRDAFPOR-UHFFFAOYSA-N 132348 US8841312, 94 Cyclin-dependent kinase 6 Homo sapiens 9.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132348&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299961 242055315 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265333 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(NC4CCNCC4)nn3)nc12 InChI=1S/C23H27N9/c1-2-4-16(3-1)32-19-14-25-12-9-17(19)18-13-26-23(29-22(18)32)28-21-6-5-20(30-31-21)27-15-7-10-24-11-8-15/h5-6,9,12-16,24H,1-4,7-8,10-11H2,(H,27,30)(H,26,28,29,31) VXTCGNYHDLHMIV-UHFFFAOYSA-N 132350 US8841312, 96 Cyclin-dependent kinase 6 Homo sapiens 12.4 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132350&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300002 242055317 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265334 C(Nc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1)C1CNC1 InChI=1S/C22H25N9/c1-2-4-15(3-1)31-18-13-23-8-7-16(18)17-12-26-22(28-21(17)31)27-20-6-5-19(29-30-20)25-11-14-9-24-10-14/h5-8,12-15,24H,1-4,9-11H2,(H,25,29)(H,26,27,28,30) WSGLUFHKWDKYLV-UHFFFAOYSA-N 132351 US8841312, 97 Cyclin-dependent kinase 6 Homo sapiens 396 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132351&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300109 242055318 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265335 C(Nc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1)C1CCNC1 InChI=1S/C23H27N9/c1-2-4-16(3-1)32-19-14-25-10-8-17(19)18-13-27-23(29-22(18)32)28-21-6-5-20(30-31-21)26-12-15-7-9-24-11-15/h5-6,8,10,13-16,24H,1-4,7,9,11-12H2,(H,26,30)(H,27,28,29,31) KRDTUJDAEVGZCU-UHFFFAOYSA-N 132352 US8841312, 98 Cyclin-dependent kinase 6 Homo sapiens 26.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132352&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300126 242055319 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265336 NCC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C24H29N9/c25-13-16-8-11-32(12-9-16)22-6-5-21(30-31-22)28-24-27-14-19-18-7-10-26-15-20(18)33(23(19)29-24)17-3-1-2-4-17/h5-7,10,14-17H,1-4,8-9,11-13,25H2,(H,27,28,29,30) QJPGYWGHFLUOIS-UHFFFAOYSA-N 132355 US8841312, 101 Cyclin-dependent kinase 6 Homo sapiens 8.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132355&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299876 242055322 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265337 OC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H26N8O/c32-16-8-11-30(12-9-16)21-6-5-20(28-29-21)26-23-25-13-18-17-7-10-24-14-19(17)31(22(18)27-23)15-3-1-2-4-15/h5-7,10,13-16,32H,1-4,8-9,11-12H2,(H,25,26,27,28) ICHZFBRRGBOMQI-UHFFFAOYSA-N 132356 US8841312, 102 Cyclin-dependent kinase 6 Homo sapiens 11.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132356&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299803 242055323 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265338 OCC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C24H28N8O/c33-15-16-8-11-31(12-9-16)22-6-5-21(29-30-22)27-24-26-13-19-18-7-10-25-14-20(18)32(23(19)28-24)17-3-1-2-4-17/h5-7,10,13-14,16-17,33H,1-4,8-9,11-12,15H2,(H,26,27,28,29) UPAMTEZWUWUYNR-UHFFFAOYSA-N 132357 US8841312, 103 Cyclin-dependent kinase 6 Homo sapiens 2.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132357&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299680 242055324 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265339 O[C@@H]1CCCN(C1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H26N8O/c32-16-6-3-11-30(14-16)21-8-7-20(28-29-21)26-23-25-12-18-17-9-10-24-13-19(17)31(22(18)27-23)15-4-1-2-5-15/h7-10,12-13,15-16,32H,1-6,11,14H2,(H,25,26,27,28)/t16-/m1/s1 JGXWHAWACJWVKA-MRXNPFEDSA-N 132358 US8841312, 104 Cyclin-dependent kinase 6 Homo sapiens 14 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132358&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299735 242055325 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265340 O[C@H]1CCCN(C1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H26N8O/c32-16-6-3-11-30(14-16)21-8-7-20(28-29-21)26-23-25-12-18-17-9-10-24-13-19(17)31(22(18)27-23)15-4-1-2-5-15/h7-10,12-13,15-16,32H,1-6,11,14H2,(H,25,26,27,28)/t16-/m0/s1 JGXWHAWACJWVKA-INIZCTEOSA-N 132359 US8841312, 105 Cyclin-dependent kinase 6 Homo sapiens 7.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132359&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299953 242055326 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265341 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCOCC3)nc12 InChI=1S/C22H24N8O/c1-2-4-15(3-1)30-18-14-23-8-7-16(18)17-13-24-22(26-21(17)30)25-19-5-6-20(28-27-19)29-9-11-31-12-10-29/h5-8,13-15H,1-4,9-12H2,(H,24,25,26,27) HFCRZSDUGZDJHM-UHFFFAOYSA-N 132360 US8841312, 106 Cyclin-dependent kinase 6 Homo sapiens 24.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132360&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300111 242055327 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265342 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCCCC3)nc12 InChI=1S/C23H26N8/c1-4-12-30(13-5-1)21-9-8-20(28-29-21)26-23-25-14-18-17-10-11-24-15-19(17)31(22(18)27-23)16-6-2-3-7-16/h8-11,14-16H,1-7,12-13H2,(H,25,26,27,28) VGPGCCHHKHQDOQ-UHFFFAOYSA-N 132361 US8841312, 107 Cyclin-dependent kinase 6 Homo sapiens 48 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132361&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299878 242055328 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265343 N[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C22H25N9/c23-14-8-10-30(13-14)20-6-5-19(28-29-20)26-22-25-11-17-16-7-9-24-12-18(16)31(21(17)27-22)15-3-1-2-4-15/h5-7,9,11-12,14-15H,1-4,8,10,13,23H2,(H,25,26,27,28)/t14-/m0/s1 FDNONPIMUKKMQB-AWEZNQCLSA-N 132362 US8841312, 108 Cyclin-dependent kinase 6 Homo sapiens 15.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132362&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299894 242055329 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265344 N[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C22H25N9/c23-14-8-10-30(13-14)20-6-5-19(28-29-20)26-22-25-11-17-16-7-9-24-12-18(16)31(21(17)27-22)15-3-1-2-4-15/h5-7,9,11-12,14-15H,1-4,8,10,13,23H2,(H,25,26,27,28)/t14-/m1/s1 FDNONPIMUKKMQB-CQSZACIVSA-N 132363 US8841312, 109 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132363&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299841 242055330 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265345 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCCC3)nc12 InChI=1S/C22H24N8/c1-2-6-15(5-1)30-18-14-23-10-9-16(18)17-13-24-22(26-21(17)30)25-19-7-8-20(28-27-19)29-11-3-4-12-29/h7-10,13-15H,1-6,11-12H2,(H,24,25,26,27) AQRSMVCQDQNUQT-UHFFFAOYSA-N 132365 US8841312, 111 Cyclin-dependent kinase 6 Homo sapiens 19.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132365&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299750 242055332 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265346 NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H27N9/c24-15-8-11-31(12-9-15)21-6-5-20(29-30-21)27-23-26-13-18-17-7-10-25-14-19(17)32(22(18)28-23)16-3-1-2-4-16/h5-7,10,13-16H,1-4,8-9,11-12,24H2,(H,26,27,28,29) PWVOSYHMZXNMBQ-UHFFFAOYSA-N 132368 US8841312, 114 Cyclin-dependent kinase 6 Homo sapiens 10 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132368&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299741 242055335 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265347 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCCNCC3)nc12 InChI=1S/C23H27N9/c1-2-5-16(4-1)32-19-15-25-10-8-17(19)18-14-26-23(28-22(18)32)27-20-6-7-21(30-29-20)31-12-3-9-24-11-13-31/h6-8,10,14-16,24H,1-5,9,11-13H2,(H,26,27,28,29) OFGLKFLIMBZBTK-UHFFFAOYSA-N 132371 US8841312, 117 Cyclin-dependent kinase 6 Homo sapiens 6.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132371&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299590 242055338 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265348 CCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C24H29N9/c1-2-31-11-13-32(14-12-31)22-8-7-21(29-30-22)27-24-26-15-19-18-9-10-25-16-20(18)33(23(19)28-24)17-5-3-4-6-17/h7-10,15-17H,2-6,11-14H2,1H3,(H,26,27,28,29) JCRIMVWZWOWOPT-UHFFFAOYSA-N 132391 US8841312, 137 Cyclin-dependent kinase 6 Homo sapiens 27 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132391&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300102 242055358 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265349 CCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C25H30N8/c1-2-31-11-13-32(14-12-31)19-7-8-23(27-15-19)29-25-28-16-21-20-9-10-26-17-22(20)33(24(21)30-25)18-5-3-4-6-18/h7-10,15-18H,2-6,11-14H2,1H3,(H,27,28,29,30) NOURLRCLQWYULH-UHFFFAOYSA-N 132393 US8841312, 139 Cyclin-dependent kinase 6 Homo sapiens 6.4 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132393&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300177 242055360 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265350 CCOC(=O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C22H22N6O2/c1-2-30-21(29)14-7-8-19(24-11-14)26-22-25-12-17-16-9-10-23-13-18(16)28(20(17)27-22)15-5-3-4-6-15/h7-13,15H,2-6H2,1H3,(H,24,25,26,27) QZYAVJILOBPGHD-UHFFFAOYSA-N 132394 US8841312, 140 Cyclin-dependent kinase 6 Homo sapiens 10000 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132394&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299657 242055361 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265351 C(N1CCOCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C24H27N7O/c1-2-4-18(3-1)31-21-15-25-8-7-19(21)20-14-27-24(29-23(20)31)28-22-6-5-17(13-26-22)16-30-9-11-32-12-10-30/h5-8,13-15,18H,1-4,9-12,16H2,(H,26,27,28,29) DSUXSBZUWGKTQG-UHFFFAOYSA-N 132395 US8841312, 141 Cyclin-dependent kinase 6 Homo sapiens 2.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132395&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300165 242055362 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265352 COCCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H32N8O/c1-35-15-14-32-10-12-33(13-11-32)20-6-7-24(28-16-20)30-26-29-17-22-21-8-9-27-18-23(21)34(25(22)31-26)19-4-2-3-5-19/h6-9,16-19H,2-5,10-15H2,1H3,(H,28,29,30,31) CXOZYBPVDKRPHI-UHFFFAOYSA-N 132396 US8841312, 142 Cyclin-dependent kinase 6 Homo sapiens 4.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132396&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299693 242055363 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265353 COCCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H31N9O/c1-35-15-14-32-10-12-33(13-11-32)23-7-6-22(30-31-23)28-25-27-16-20-19-8-9-26-17-21(19)34(24(20)29-25)18-4-2-3-5-18/h6-9,16-18H,2-5,10-15H2,1H3,(H,27,28,29,30) WTGAVGFXQHPYCN-UHFFFAOYSA-N 132397 US8841312, 143 Cyclin-dependent kinase 6 Homo sapiens 15.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132397&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300039 242055364 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265354 CCN(CC)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C28H36N8/c1-3-34(4-2)20-12-15-35(16-13-20)22-9-10-26(30-17-22)32-28-31-18-24-23-11-14-29-19-25(23)36(27(24)33-28)21-7-5-6-8-21/h9-11,14,17-21H,3-8,12-13,15-16H2,1-2H3,(H,30,31,32,33) SJWPQHGIWPYOHJ-UHFFFAOYSA-N 132398 US8841312, 144 Cyclin-dependent kinase 6 Homo sapiens 4.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132398&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299917 242055365 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265355 CCN(CC)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C27H35N9/c1-3-34(4-2)19-12-15-35(16-13-19)25-10-9-24(32-33-25)30-27-29-17-22-21-11-14-28-18-23(21)36(26(22)31-27)20-7-5-6-8-20/h9-11,14,17-20H,3-8,12-13,15-16H2,1-2H3,(H,29,30,31,32) NOUVQMCOTSOPTN-UHFFFAOYSA-N 132399 US8841312, 145 Cyclin-dependent kinase 6 Homo sapiens 5.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132399&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299725 242055366 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265356 COc1nccc2c3cnc(Nc4ccc(cn4)N4CCC(CC4)N(C)C)nc3n(C3CCCC3)c12 InChI=1S/C27H34N8O/c1-33(2)18-11-14-34(15-12-18)20-8-9-23(29-16-20)31-27-30-17-22-21-10-13-28-26(36-3)24(21)35(25(22)32-27)19-6-4-5-7-19/h8-10,13,16-19H,4-7,11-12,14-15H2,1-3H3,(H,29,30,31,32) YXBKCKHBHRIXQX-UHFFFAOYSA-N 132400 US8841312, 146 Cyclin-dependent kinase 6 Homo sapiens 33 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132400&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299819 242055367 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265357 Clc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12 InChI=1S/C23H25ClN8/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30) YKDDWNDRNJMVDF-UHFFFAOYSA-N 50001586 CHEMBL3237444::US8841312, 152 Cyclin-dependent kinase 6 Homo sapiens 4.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001586&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299601 103916016 CHEMBL3237444 ZINC13728942 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265358 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(Cl)c4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H31ClN8/c1-33(2)17-10-13-34(14-11-17)19-7-8-22(29-15-19)31-26-30-16-21-20-9-12-28-24(27)23(20)35(25(21)32-26)18-5-3-4-6-18/h7-9,12,15-18H,3-6,10-11,13-14H2,1-2H3,(H,29,30,31,32) LQLWCEYRAKKEIP-UHFFFAOYSA-N 132406 US8841312, 153 Cyclin-dependent kinase 6 Homo sapiens 2.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132406&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299831 242055373 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265359 CCC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)N(C)C)nc12 InChI=1S/C25H33N9/c1-6-25(2,3)34-20-16-26-12-9-18(20)19-15-27-24(29-23(19)34)28-21-7-8-22(31-30-21)33-13-10-17(11-14-33)32(4)5/h7-9,12,15-17H,6,10-11,13-14H2,1-5H3,(H,27,28,29,30) UJLRCOLCMNEBIT-UHFFFAOYSA-N 132409 US8841312, 156 Cyclin-dependent kinase 6 Homo sapiens 14 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132409&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300024 242055376 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265360 CCC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C23H28N8/c1-4-23(2,3)31-19-15-25-8-7-17(19)18-14-27-22(29-21(18)31)28-20-6-5-16(13-26-20)30-11-9-24-10-12-30/h5-8,13-15,24H,4,9-12H2,1-3H3,(H,26,27,28,29) BKJVBBWPOYUPFA-UHFFFAOYSA-N 132410 US8841312, 157 Cyclin-dependent kinase 6 Homo sapiens 25 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132410&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299880 242055377 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265361 CN(C)C1CC2CCC(C1)N2c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C28H34N8/c1-34(2)22-13-19-7-8-20(14-22)35(19)21-9-10-26(30-15-21)32-28-31-16-24-23-11-12-29-17-25(23)36(27(24)33-28)18-5-3-4-6-18/h9-12,15-20,22H,3-8,13-14H2,1-2H3,(H,30,31,32,33) VQPRNWUDMGAWOA-UHFFFAOYSA-N 132411 US8841312, 158 Cyclin-dependent kinase 6 Homo sapiens 5.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132411&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299795 242055378 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265362 CC(C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)N(C)C)nc12 InChI=1S/C23H29N9/c1-15(2)32-19-14-24-10-7-17(19)18-13-25-23(27-22(18)32)26-20-5-6-21(29-28-20)31-11-8-16(9-12-31)30(3)4/h5-7,10,13-16H,8-9,11-12H2,1-4H3,(H,25,26,27,28) XKPGLBSDWLZQRX-UHFFFAOYSA-N 132413 US8841312, 160 Cyclin-dependent kinase 6 Homo sapiens 4.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132413&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299660 242055380 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265363 CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C23H28N8/c1-3-16(4-2)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-21-6-5-17(13-26-21)30-11-9-24-10-12-30/h5-8,13-16,24H,3-4,9-12H2,1-2H3,(H,26,27,28,29) MXRWQCYXQVDVHQ-UHFFFAOYSA-N 132414 US8841312, 161 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132414&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300131 242055381 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265364 CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CC[C@@H](O)C3)nc12 InChI=1S/C22H26N8O/c1-3-14(4-2)30-18-12-23-9-7-16(18)17-11-24-22(26-21(17)30)25-19-5-6-20(28-27-19)29-10-8-15(31)13-29/h5-7,9,11-12,14-15,31H,3-4,8,10,13H2,1-2H3,(H,24,25,26,27)/t15-/m1/s1 JVKMOGRAZNNCJK-OAHLLOKOSA-N 132415 US8841312, 162 Cyclin-dependent kinase 6 Homo sapiens 110 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132415&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300038 242055382 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265365 CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)N(C)C)nc12 InChI=1S/C25H33N9/c1-5-17(6-2)34-21-16-26-12-9-19(21)20-15-27-25(29-24(20)34)28-22-7-8-23(31-30-22)33-13-10-18(11-14-33)32(3)4/h7-9,12,15-18H,5-6,10-11,13-14H2,1-4H3,(H,27,28,29,30) FUHVDXOTJYWTON-UHFFFAOYSA-N 132416 US8841312, 163 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132416&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299679 242055383 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265366 C(N1CCNCC1)c1csc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)n1 InChI=1S/C22H26N8S/c1-2-4-16(3-1)30-19-12-24-6-5-17(19)18-11-25-21(27-20(18)30)28-22-26-15(14-31-22)13-29-9-7-23-8-10-29/h5-6,11-12,14,16,23H,1-4,7-10,13H2,(H,25,26,27,28) XWWYSAVKDKITGM-UHFFFAOYSA-N 132417 US8841312, 164 Cyclin-dependent kinase 6 Homo sapiens 6.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132417&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299573 242055384 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265367 O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)n2)C1 InChI=1S/C22H25N7OS/c30-16-6-8-28(12-16)11-14-13-31-22(25-14)27-21-24-9-18-17-5-7-23-10-19(17)29(20(18)26-21)15-3-1-2-4-15/h5,7,9-10,13,15-16,30H,1-4,6,8,11-12H2,(H,24,25,26,27)/t16-/m0/s1 QKWGQKPKINEBOT-INIZCTEOSA-N 132418 US8841312, 165 Cyclin-dependent kinase 6 Homo sapiens 17 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132418&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299825 242055385 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265368 FC(F)(F)C1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C24H25F3N8/c25-24(26,27)20-14-34(10-9-29-20)16-5-6-21(30-11-16)32-23-31-12-18-17-7-8-28-13-19(17)35(22(18)33-23)15-3-1-2-4-15/h5-8,11-13,15,20,29H,1-4,9-10,14H2,(H,30,31,32,33) HMXNJXIHQSSEJY-UHFFFAOYSA-N 132420 US8841312, 167 Cyclin-dependent kinase 6 Homo sapiens 21 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132420&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44132902 242055387 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265369 C1CCC(C1)n1c2cnsc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C21H24N8S/c1-2-4-14(3-1)29-17-13-25-30-19(17)16-12-24-21(27-20(16)29)26-18-6-5-15(11-23-18)28-9-7-22-8-10-28/h5-6,11-14,22H,1-4,7-10H2,(H,23,24,26,27) FPCMXTPKEVSVSI-UHFFFAOYSA-N 132421 US8841312, 168 Cyclin-dependent kinase 6 Homo sapiens 10000 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132421&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299779 242055388 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265370 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(CC4CC4)c3n2)nn1 InChI=1S/C24H28FN9/c1-32(2)16-8-11-33(12-9-16)20-6-5-19(30-31-20)28-24-27-13-18-17-7-10-26-22(25)21(17)34(23(18)29-24)14-15-3-4-15/h5-7,10,13,15-16H,3-4,8-9,11-12,14H2,1-2H3,(H,27,28,29,30) HPSQCNGDSWWUNK-UHFFFAOYSA-N 132422 US8841312, 169 Cyclin-dependent kinase 6 Homo sapiens 150 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132422&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299677 242055389 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265371 O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)n2)C1 InChI=1S/C22H24FN7OS/c23-19-18-16(5-7-24-19)17-9-25-21(27-20(17)30(18)14-3-1-2-4-14)28-22-26-13(12-32-22)10-29-8-6-15(31)11-29/h5,7,9,12,14-15,31H,1-4,6,8,10-11H2,(H,25,26,27,28)/t15-/m0/s1 NLFOYPRDIYQCLG-HNNXBMFYSA-N 132434 US8841312, 181 Cyclin-dependent kinase 6 Homo sapiens 26 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132434&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299957 242055400 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265372 COc1ccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2n1 InChI=1S/C24H28N8O/c1-33-21-9-7-18-19-15-27-24(30-23(19)32(22(18)29-21)16-4-2-3-5-16)28-20-8-6-17(14-26-20)31-12-10-25-11-13-31/h6-9,14-16,25H,2-5,10-13H2,1H3,(H,26,27,28,30) IYYKYLPYCPFJHV-UHFFFAOYSA-N 132435 US8841312, 182 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132435&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299574 242055401 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265373 Oc1ccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2n1 InChI=1S/C23H26N8O/c32-20-8-6-17-18-14-26-23(29-22(18)31(21(17)28-20)15-3-1-2-4-15)27-19-7-5-16(13-25-19)30-11-9-24-10-12-30/h5-8,13-15,24H,1-4,9-12H2,(H,28,32)(H,25,26,27,29) WAOFSGJFQLXAOO-UHFFFAOYSA-N 132436 US8841312, 183 Cyclin-dependent kinase 6 Homo sapiens 104 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132436&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299734 242055402 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265374 Cn1c2n(C3CCCC3)c3nc(Nc4ccc(cn4)N4CCNCC4)ncc3c2ccc1=O InChI=1S/C24H28N8O/c1-30-21(33)9-7-18-19-15-27-24(29-22(19)32(23(18)30)16-4-2-3-5-16)28-20-8-6-17(14-26-20)31-12-10-25-11-13-31/h6-9,14-16,25H,2-5,10-13H2,1H3,(H,26,27,28,29) NVMQZCJPKNUECR-UHFFFAOYSA-N 132437 US8841312, 184 Cyclin-dependent kinase 6 Homo sapiens 31 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132437&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299854 242055403 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265375 Cn1c2n(C3CCCC3)c3nc(Nc4ccc(cn4)N4CC[C@@H](O)C4)ncc3c2ccc1=O InChI=1S/C24H27N7O2/c1-29-21(33)9-7-18-19-13-26-24(28-22(19)31(23(18)29)15-4-2-3-5-15)27-20-8-6-16(12-25-20)30-11-10-17(32)14-30/h6-9,12-13,15,17,32H,2-5,10-11,14H2,1H3,(H,25,26,27,28)/t17-/m1/s1 CLUCXVSOAQMMRQ-QGZVFWFLSA-N 132438 US8841312, 185 Cyclin-dependent kinase 6 Homo sapiens 149 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132438&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299984 242055404 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265376 O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nc1 InChI=1S/C23H24FN7O/c24-21-20-17(7-9-25-21)18-12-27-23(29-22(18)31(20)14-3-1-2-4-14)28-19-6-5-15(11-26-19)30-10-8-16(32)13-30/h5-7,9,11-12,14,16,32H,1-4,8,10,13H2,(H,26,27,28,29)/t16-/m1/s1 CFZGMAQTSTWGSI-MRXNPFEDSA-N 132439 US8841312, 186A Cyclin-dependent kinase 6 Homo sapiens 2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132439&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299703 242055405 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265377 O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nc1 InChI=1S/C23H24FN7O/c24-21-20-17(7-9-25-21)18-12-27-23(29-22(18)31(20)14-3-1-2-4-14)28-19-6-5-15(11-26-19)30-10-8-16(32)13-30/h5-7,9,11-12,14,16,32H,1-4,8,10,13H2,(H,26,27,28,29)/t16-/m0/s1 CFZGMAQTSTWGSI-INIZCTEOSA-N 132440 US8841312, 186B Cyclin-dependent kinase 6 Homo sapiens 4.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132440&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300028 242055406 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265378 OCC1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1 InChI=1S/C25H28FN7O/c26-23-22-19(7-10-27-23)20-14-29-25(31-24(20)33(22)17-3-1-2-4-17)30-21-6-5-18(13-28-21)32-11-8-16(15-34)9-12-32/h5-7,10,13-14,16-17,34H,1-4,8-9,11-12,15H2,(H,28,29,30,31) GFUYDGPHKDLMHQ-UHFFFAOYSA-N 132441 US8841312, 187 Cyclin-dependent kinase 6 Homo sapiens 2.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132441&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299866 242055407 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265379 N#Cc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12 InChI=1S/C24H25N9/c25-13-20-22-18(7-8-27-20)19-15-29-24(31-23(19)33(22)16-3-1-2-4-16)30-21-6-5-17(14-28-21)32-11-9-26-10-12-32/h5-8,14-16,26H,1-4,9-12H2,(H,28,29,30,31) UOXNTMLLQKBLLA-UHFFFAOYSA-N 50001532 CHEMBL3237447::US8841312, 188 Cyclin-dependent kinase 6 Homo sapiens 13.4 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001532&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299570 242055952 CHEMBL3237447 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265380 CC1CN(CC(C)N1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1 InChI=1S/C25H29FN8/c1-15-13-33(14-16(2)30-15)18-7-8-21(28-11-18)31-25-29-12-20-19-9-10-27-23(26)22(19)34(24(20)32-25)17-5-3-4-6-17/h7-12,15-17,30H,3-6,13-14H2,1-2H3,(H,28,29,31,32) JRVLCPFGZSZGRN-UHFFFAOYSA-N 132442 US8841312, 189 Cyclin-dependent kinase 6 Homo sapiens 22 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132442&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299846 242055408 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265381 OCCC1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H30FN7O/c27-24-23-20(7-11-28-24)21-16-30-26(32-25(21)34(23)18-3-1-2-4-18)31-22-6-5-19(15-29-22)33-12-8-17(9-13-33)10-14-35/h5-7,11,15-18,35H,1-4,8-10,12-14H2,(H,29,30,31,32) VGMLIUVYQAAPOV-UHFFFAOYSA-N 132443 US8841312, 190 Cyclin-dependent kinase 6 Homo sapiens 7.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132443&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300158 242055409 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265382 OCCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C25H30N8O/c34-14-13-31-9-11-32(12-10-31)19-5-6-23(27-15-19)29-25-28-16-21-20-7-8-26-17-22(20)33(24(21)30-25)18-3-1-2-4-18/h5-8,15-18,34H,1-4,9-14H2,(H,27,28,29,30) OXTMSCZUAJMZIC-UHFFFAOYSA-N 132444 US8841312, 191 Cyclin-dependent kinase 6 Homo sapiens 4.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132444&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299810 242055410 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265383 C1CCC(C1)n1c2nnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C22H25N9/c1-2-4-15(3-1)31-20-18(17-7-8-26-29-21(17)31)14-25-22(28-20)27-19-6-5-16(13-24-19)30-11-9-23-10-12-30/h5-8,13-15,23H,1-4,9-12H2,(H,24,25,27,28) BOEVQFOAJBRYBJ-UHFFFAOYSA-N 50001533 CHEMBL3237448::US8841312, 200 Cyclin-dependent kinase 6 Homo sapiens 13 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001533&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300060 242055953 CHEMBL3237448 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265384 COc1cc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2nn1 InChI=1S/C23H27N9O/c1-33-20-12-17-18-14-26-23(27-19-7-6-16(13-25-19)31-10-8-24-9-11-31)28-21(18)32(22(17)30-29-20)15-4-2-3-5-15/h6-7,12-15,24H,2-5,8-11H2,1H3,(H,25,26,27,28) ZCZWCPYCSYTXDF-UHFFFAOYSA-N 132454 US8841312, 202 Cyclin-dependent kinase 6 Homo sapiens 520 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132454&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300055 242055420 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265385 CC1(C)CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C26H32N8/c1-26(2)8-5-18(6-9-26)34-22-17-28-10-7-20(22)21-16-30-25(32-24(21)34)31-23-4-3-19(15-29-23)33-13-11-27-12-14-33/h3-4,7,10,15-18,27H,5-6,8-9,11-14H2,1-2H3,(H,29,30,31,32) ZEWPRVBMQMQROZ-UHFFFAOYSA-N 50001539 CHEMBL3237704::US8841312, 204 Cyclin-dependent kinase 6 Homo sapiens 1.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001539&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299870 242055959 CHEMBL3237704 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265386 C(N1CCNCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C24H28N8/c1-2-4-18(3-1)32-21-15-26-8-7-19(21)20-14-28-24(30-23(20)32)29-22-6-5-17(13-27-22)16-31-11-9-25-10-12-31/h5-8,13-15,18,25H,1-4,9-12,16H2,(H,27,28,29,30) QDOVUCKBHKKVRH-UHFFFAOYSA-N 132463 US8841312, 212 Cyclin-dependent kinase 6 Homo sapiens 33 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132463&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44132903 242055429 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265387 Fc1nccc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c12 InChI=1S/C24H27FN8/c25-22-21-18(7-8-27-22)19-14-29-24(31-23(19)33(21)17-3-1-2-4-17)30-20-6-5-16(13-28-20)15-32-11-9-26-10-12-32/h5-8,13-14,17,26H,1-4,9-12,15H2,(H,28,29,30,31) VZTCGTGRVPUXNQ-UHFFFAOYSA-N 132464 US8841312, 213 Cyclin-dependent kinase 6 Homo sapiens 52 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132464&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299989 242055430 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265388 Oc1nccc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c12 InChI=1S/C24H28N8O/c33-23-21-18(7-8-26-23)19-14-28-24(30-22(19)32(21)17-3-1-2-4-17)29-20-6-5-16(13-27-20)15-31-11-9-25-10-12-31/h5-8,13-14,17,25H,1-4,9-12,15H2,(H,26,33)(H,27,28,29,30) JGZXCZPRYTYKPZ-UHFFFAOYSA-N 132465 US8841312, 214 Cyclin-dependent kinase 6 Homo sapiens 21 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132465&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299938 242055431 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265389 OC1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 InChI=1S/C25H29N7O/c33-19-8-11-31(12-9-19)16-17-5-6-23(27-13-17)29-25-28-14-21-20-7-10-26-15-22(20)32(24(21)30-25)18-3-1-2-4-18/h5-7,10,13-15,18-19,33H,1-4,8-9,11-12,16H2,(H,27,28,29,30) HZNBZEKLTOCERM-UHFFFAOYSA-N 132466 US8841312, 215 Cyclin-dependent kinase 6 Homo sapiens 8.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132466&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299653 242055432 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265390 OC1CCCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 InChI=1S/C25H29N7O/c33-19-6-3-11-31(16-19)15-17-7-8-23(27-12-17)29-25-28-13-21-20-9-10-26-14-22(20)32(24(21)30-25)18-4-1-2-5-18/h7-10,12-14,18-19,33H,1-6,11,15-16H2,(H,27,28,29,30) VKMLLLMORNMXCU-UHFFFAOYSA-N 132467 US8841312, 216 Cyclin-dependent kinase 6 Homo sapiens 15 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132467&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300127 242055433 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265391 CCOC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H31N9O2/c1-2-37-24(36)17-33-11-13-34(14-12-33)23-8-7-22(31-32-23)29-26-28-15-20-19-9-10-27-16-21(19)35(25(20)30-26)18-5-3-4-6-18/h7-10,15-16,18H,2-6,11-14,17H2,1H3,(H,28,29,30,31) HVGWRZOBPIJOSS-UHFFFAOYSA-N 132468 US8841312, 217 Cyclin-dependent kinase 6 Homo sapiens 9.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132468&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299768 242055434 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265392 OC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C24H27N9O2/c34-22(35)15-31-9-11-32(12-10-31)21-6-5-20(29-30-21)27-24-26-13-18-17-7-8-25-14-19(17)33(23(18)28-24)16-3-1-2-4-16/h5-8,13-14,16H,1-4,9-12,15H2,(H,34,35)(H,26,27,28,29) VNRANBWAFHAFQG-UHFFFAOYSA-N 132469 US8841312, 218 Cyclin-dependent kinase 6 Homo sapiens 3.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132469&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300040 242055435 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265393 CCOC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 InChI=1S/C28H34N8O2/c1-2-38-26(37)19-35-13-11-34(12-14-35)18-20-7-8-25(30-15-20)32-28-31-16-23-22-9-10-29-17-24(22)36(27(23)33-28)21-5-3-4-6-21/h7-10,15-17,21H,2-6,11-14,18-19H2,1H3,(H,30,31,32,33) ATJYDIOQFNWQJX-UHFFFAOYSA-N 132470 US8841312, 219 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132470&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299758 242055436 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265394 OC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 InChI=1S/C26H30N8O2/c35-24(36)17-33-11-9-32(10-12-33)16-18-5-6-23(28-13-18)30-26-29-14-21-20-7-8-27-15-22(20)34(25(21)31-26)19-3-1-2-4-19/h5-8,13-15,19H,1-4,9-12,16-17H2,(H,35,36)(H,28,29,30,31) IYLQAMPBXDBIFL-UHFFFAOYSA-N 132471 US8841312, 220 Cyclin-dependent kinase 6 Homo sapiens 3.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132471&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299639 242055437 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265395 O=C(N1CCNCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C24H26N8O/c33-23(31-11-9-25-10-12-31)16-5-6-21(27-13-16)29-24-28-14-19-18-7-8-26-15-20(18)32(22(19)30-24)17-3-1-2-4-17/h5-8,13-15,17,25H,1-4,9-12H2,(H,27,28,29,30) CNEMATMUMUNODK-UHFFFAOYSA-N 132472 US8841312, 221 Cyclin-dependent kinase 6 Homo sapiens 8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132472&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299619 242055438 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265396 OC(=O)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(O)nccc32)nc1 InChI=1S/C20H18N6O3/c27-18-16-13(7-8-21-18)14-10-23-20(24-15-6-5-11(9-22-15)19(28)29)25-17(14)26(16)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,21,27)(H,28,29)(H,22,23,24,25) FWKJOFFEPRZHEJ-UHFFFAOYSA-N 132475 US8841312, 224 Cyclin-dependent kinase 6 Homo sapiens 860 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132475&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299691 242055441 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265397 O=C1CN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 InChI=1S/C24H26N8O/c33-22-15-31(10-9-26-22)14-16-5-6-21(27-11-16)29-24-28-12-19-18-7-8-25-13-20(18)32(23(19)30-24)17-3-1-2-4-17/h5-8,11-13,17H,1-4,9-10,14-15H2,(H,26,33)(H,27,28,29,30) HMUKVTQDAZQBHU-UHFFFAOYSA-N 132476 US8841312, 225 Cyclin-dependent kinase 6 Homo sapiens 3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132476&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299871 242055442 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265398 O=C1CNCCN1Cc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C24H26N8O/c33-22-14-26-9-10-31(22)15-16-5-6-21(27-11-16)29-24-28-12-19-18-7-8-25-13-20(18)32(23(19)30-24)17-3-1-2-4-17/h5-8,11-13,17,26H,1-4,9-10,14-15H2,(H,27,28,29,30) QXZISVGKZJBIFK-UHFFFAOYSA-N 132477 US8841312, 226 Cyclin-dependent kinase 6 Homo sapiens 2.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132477&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300147 242055443 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265399 O=S(=O)(N1CCNCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C23H26N8O2S/c32-34(33,30-11-9-24-10-12-30)17-5-6-21(26-13-17)28-23-27-14-19-18-7-8-25-15-20(18)31(22(19)29-23)16-3-1-2-4-16/h5-8,13-16,24H,1-4,9-12H2,(H,26,27,28,29) XGQSZIVZWJHPHL-UHFFFAOYSA-N 132478 US8841312, 227 Cyclin-dependent kinase 6 Homo sapiens 3.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132478&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299914 242055444 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265400 Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12 InChI=1S/C23H25FN8O2S/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)35(33,34)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30) UCTSPGHNUJSBEO-UHFFFAOYSA-N 132479 US8841312, 228 Cyclin-dependent kinase 6 Homo sapiens 3.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132479&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300118 242055445 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265401 CN(C)C1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H32N8O2S/c1-32(2)18-10-13-33(14-11-18)37(35,36)20-7-8-24(28-15-20)30-26-29-16-22-21-9-12-27-17-23(21)34(25(22)31-26)19-5-3-4-6-19/h7-9,12,15-19H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31) RJOAAVPWGOLZSU-UHFFFAOYSA-N 132480 US8841312, 229 Cyclin-dependent kinase 6 Homo sapiens 20.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132480&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299788 242055446 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265402 CN(C)C1CCN(CC1)C(=O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H32N8O/c1-33(2)19-10-13-34(14-11-19)26(36)18-7-8-24(29-15-18)31-27-30-16-22-21-9-12-28-17-23(21)35(25(22)32-27)20-5-3-4-6-20/h7-9,12,15-17,19-20H,3-6,10-11,13-14H2,1-2H3,(H,29,30,31,32) XMDZCLSJGZZXSD-UHFFFAOYSA-N 132481 US8841312, 230 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132481&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299716 242055447 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265403 C1CN(CCN1)c1ccc(Nc2cc3n(-c4ccccc4)c4cnccc4c3cn2)nc1 InChI=1S/C25H23N7/c1-2-4-18(5-3-1)32-22-14-25(29-16-21(22)20-8-9-27-17-23(20)32)30-24-7-6-19(15-28-24)31-12-10-26-11-13-31/h1-9,14-17,26H,10-13H2,(H,28,29,30) FRNNWASSAAUPGS-UHFFFAOYSA-N 132484 US8841312, 233 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132484&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299893 242055450 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265404 FC(F)(F)c1cccc(c1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 InChI=1S/C26H22F3N7/c27-26(28,29)17-2-1-3-18(12-17)36-22-13-25(33-15-21(22)20-6-7-31-16-23(20)36)34-24-5-4-19(14-32-24)35-10-8-30-9-11-35/h1-7,12-16,30H,8-11H2,(H,32,33,34) HHFXMDZWCLHCFZ-UHFFFAOYSA-N 132485 US8841312, 234 Cyclin-dependent kinase 6 Homo sapiens 26 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132485&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300063 242055451 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265405 C(c1ccsc1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 InChI=1S/C24H23N7S/c1-2-23(27-12-18(1)30-8-6-25-7-9-30)29-24-11-21-20(13-28-24)19-3-5-26-14-22(19)31(21)15-17-4-10-32-16-17/h1-5,10-14,16,25H,6-9,15H2,(H,27,28,29) YITZLEHWDLDKBR-UHFFFAOYSA-N 132486 US8841312, 235 Cyclin-dependent kinase 6 Homo sapiens 257 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132486&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300203 242055452 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265406 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 InChI=1S/C24H27N7/c1-2-4-17(3-1)31-21-13-24(28-15-20(21)19-7-8-26-16-22(19)31)29-23-6-5-18(14-27-23)30-11-9-25-10-12-30/h5-8,13-17,25H,1-4,9-12H2,(H,27,28,29) JESGKYVOWCEUEO-UHFFFAOYSA-N 132487 US8841312, 236 Cyclin-dependent kinase 6 Homo sapiens 112 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132487&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300154 242055453 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265407 C(c1cccs1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 InChI=1S/C24H23N7S/c1-2-18(32-11-1)16-31-21-12-24(28-14-20(21)19-5-6-26-15-22(19)31)29-23-4-3-17(13-27-23)30-9-7-25-8-10-30/h1-6,11-15,25H,7-10,16H2,(H,27,28,29) SDRUQGPFTWNIMT-UHFFFAOYSA-N 132488 US8841312, 237 Cyclin-dependent kinase 6 Homo sapiens 131 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132488&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299958 242055454 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265408 OC(=O)Cc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 InChI=1S/C27H25N7O2/c35-27(36)13-18-1-3-19(4-2-18)34-23-14-26(31-16-22(23)21-7-8-29-17-24(21)34)32-25-6-5-20(15-30-25)33-11-9-28-10-12-33/h1-8,14-17,28H,9-13H2,(H,35,36)(H,30,31,32) XBDBJEAKPCJTPF-UHFFFAOYSA-N 132489 US8841312, 238 Cyclin-dependent kinase 6 Homo sapiens 178 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132489&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299635 242055455 C03768 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265409 C1CC(CS1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 InChI=1S/C23H25N7S/c1-2-22(26-12-16(1)29-8-6-24-7-9-29)28-23-11-20-19(13-27-23)18-3-5-25-14-21(18)30(20)17-4-10-31-15-17/h1-3,5,11-14,17,24H,4,6-10,15H2,(H,26,27,28) JYKPIJBIXXIDKG-UHFFFAOYSA-N 132490 US8841312, 239 Cyclin-dependent kinase 6 Homo sapiens 17 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132490&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299798 242055456 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265410 C1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 InChI=1S/C25H29N7/c1-2-4-18(5-3-1)32-22-14-25(29-16-21(22)20-8-9-27-17-23(20)32)30-24-7-6-19(15-28-24)31-12-10-26-11-13-31/h6-9,14-18,26H,1-5,10-13H2,(H,28,29,30) JNWDMRNNBZSXQY-UHFFFAOYSA-N 132491 US8841312, 240 Cyclin-dependent kinase 6 Homo sapiens 4.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132491&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299638 242055457 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265411 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H30FN9/c1-33(2)16-10-13-34(14-11-16)21-8-7-20(31-32-21)29-25-28-15-19-18-9-12-27-23(26)22(18)35(24(19)30-25)17-5-3-4-6-17/h7-9,12,15-17H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31) DYYOXQSHYDLEFT-UHFFFAOYSA-N 132503 US8841312, 252 Cyclin-dependent kinase 6 Homo sapiens 5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132503&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299887 242055469 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265412 C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H26FN9/c1-14-13-32(11-10-25-14)19-7-6-18(30-31-19)28-23-27-12-17-16-8-9-26-21(24)20(16)33(22(17)29-23)15-4-2-3-5-15/h6-9,12,14-15,25H,2-5,10-11,13H2,1H3,(H,27,28,29,30)/t14-/m1/s1 MAVGAHAOCLDZKW-CQSZACIVSA-N 132504 US8841312, 253 Cyclin-dependent kinase 6 Homo sapiens 27 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132504&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299661 242055470 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265413 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC=CC3)nc12 InChI=1S/C23H24N8/c1-4-12-30(13-5-1)21-9-8-20(28-29-21)26-23-25-14-18-17-10-11-24-15-19(17)31(22(18)27-23)16-6-2-3-7-16/h1,4,8-11,14-16H,2-3,5-7,12-13H2,(H,25,26,27,28) JYVQQVITMQSABB-UHFFFAOYSA-N 132505 US8841312, 254 Cyclin-dependent kinase 6 Homo sapiens 40 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132505&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44132906 242055471 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265414 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)C3=CCNCC3)nc12 InChI=1S/C23H24N8/c1-2-4-16(3-1)31-20-14-25-12-9-17(20)18-13-26-23(28-22(18)31)27-21-6-5-19(29-30-21)15-7-10-24-11-8-15/h5-7,9,12-14,16,24H,1-4,8,10-11H2,(H,26,27,28,30) BGYGYQGUFXBQFT-UHFFFAOYSA-N 132506 US8841312, 255 Cyclin-dependent kinase 6 Homo sapiens 60 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132506&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299949 242055472 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265415 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)C3=CCNCC3)nc12 InChI=1S/C24H25N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-7,9,12-15,18,25H,1-4,8,10-11H2,(H,27,28,29,30) DHQTVQLYTCGZPM-UHFFFAOYSA-N 132507 US8841312, 256 Cyclin-dependent kinase 6 Homo sapiens 7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132507&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300017 242055473 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265416 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)C3CCNCC3)nc12 InChI=1S/C24H27N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-6,9,12-16,18,25H,1-4,7-8,10-11H2,(H,27,28,29,30) OIJRETQRRUTHKW-UHFFFAOYSA-N 132508 US8841312, 257 Cyclin-dependent kinase 6 Homo sapiens 5.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132508&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300136 242055474 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265417 CN(C)C1CN(CCC1O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H31N9O/c1-32(2)20-15-33(12-10-21(20)35)23-8-7-22(30-31-23)28-25-27-13-18-17-9-11-26-14-19(17)34(24(18)29-25)16-5-3-4-6-16/h7-9,11,13-14,16,20-21,35H,3-6,10,12,15H2,1-2H3,(H,27,28,29,30) XNFJUHZLDMOZHP-UHFFFAOYSA-N 132733 US8841312, 258 Cyclin-dependent kinase 6 Homo sapiens 13.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132733&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300066 242055697 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265418 CN(C)[C@@H]1CN(CC[C@H]1O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H31N9O/c1-32(2)20-15-33(12-10-21(20)35)23-8-7-22(30-31-23)28-25-27-13-18-17-9-11-26-14-19(17)34(24(18)29-25)16-5-3-4-6-16/h7-9,11,13-14,16,20-21,35H,3-6,10,12,15H2,1-2H3,(H,27,28,29,30)/t20-,21-/m1/s1 XNFJUHZLDMOZHP-NHCUHLMSSA-N 132732 US8841312, 258a Cyclin-dependent kinase 6 Homo sapiens 41 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132732&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299976 242055696 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265419 CN(C)[C@H]1CN(CC[C@@H]1O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H31N9O/c1-32(2)20-15-33(12-10-21(20)35)23-8-7-22(30-31-23)28-25-27-13-18-17-9-11-26-14-19(17)34(24(18)29-25)16-5-3-4-6-16/h7-9,11,13-14,16,20-21,35H,3-6,10,12,15H2,1-2H3,(H,27,28,29,30)/t20-,21-/m0/s1 XNFJUHZLDMOZHP-SFTDATJTSA-N 132509 US8841312, 258b Cyclin-dependent kinase 6 Homo sapiens 24 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132509&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299718 242055475 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265420 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)-c3ccncc3)nc12 InChI=1S/C23H20N8/c1-2-4-16(3-1)31-20-14-25-12-9-17(20)18-13-26-23(28-22(18)31)27-21-6-5-19(29-30-21)15-7-10-24-11-8-15/h5-14,16H,1-4H2,(H,26,27,28,30) MIJLYWBJXSCQRT-UHFFFAOYSA-N 132510 US8841312, 259 Cyclin-dependent kinase 6 Homo sapiens 101 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132510&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299927 242055476 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265421 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)-c3ccncc3)nc12 InChI=1S/C24H21N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-15,18H,1-4H2,(H,27,28,29,30) JBWJGEZTYVAWBR-UHFFFAOYSA-N 132511 US8841312, 260 Cyclin-dependent kinase 6 Homo sapiens 60 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132511&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299983 242055477 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265422 COc1ccc(cn1)-c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C24H22N8O/c1-33-22-9-6-15(12-26-22)19-7-8-21(31-30-19)28-24-27-13-18-17-10-11-25-14-20(17)32(23(18)29-24)16-4-2-3-5-16/h6-14,16H,2-5H2,1H3,(H,27,28,29,31) BZXZKWSLTSIOMY-UHFFFAOYSA-N 132512 US8841312, 261 Cyclin-dependent kinase 6 Homo sapiens 360 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132512&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299940 242055478 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265423 COc1cc(ccn1)-c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C24H22N8O/c1-33-22-12-15(8-11-26-22)19-6-7-21(31-30-19)28-24-27-13-18-17-9-10-25-14-20(17)32(23(18)29-24)16-4-2-3-5-16/h6-14,16H,2-5H2,1H3,(H,27,28,29,31) HLUPUMQWJOFHGU-UHFFFAOYSA-N 132513 US8841312, 262 Cyclin-dependent kinase 6 Homo sapiens 38 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132513&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299968 242055479 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265424 Oc1cc(ccn1)-c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C23H20N8O/c32-21-11-14(7-10-25-21)18-5-6-20(30-29-18)27-23-26-12-17-16-8-9-24-13-19(16)31(22(17)28-23)15-3-1-2-4-15/h5-13,15H,1-4H2,(H,25,32)(H,26,27,28,30) HFDFGDRLZTUDLX-UHFFFAOYSA-N 132515 US8841312, 264 Cyclin-dependent kinase 6 Homo sapiens 16.6 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132515&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299767 242055481 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265425 O=S1(=O)CCC(=CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C24H24N6O2S/c31-33(32)11-8-16(9-12-33)17-5-6-22(26-13-17)28-24-27-14-20-19-7-10-25-15-21(19)30(23(20)29-24)18-3-1-2-4-18/h5-8,10,13-15,18H,1-4,9,11-12H2,(H,26,27,28,29) OAWKAAOUONBYOS-UHFFFAOYSA-N 132516 US8841312, 265 Cyclin-dependent kinase 6 Homo sapiens 2.2 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132516&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299598 242055482 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265426 Oc1ccc(cn1)-c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C23H20N8O/c32-21-8-5-14(11-25-21)18-6-7-20(30-29-18)27-23-26-12-17-16-9-10-24-13-19(16)31(22(17)28-23)15-3-1-2-4-15/h5-13,15H,1-4H2,(H,25,32)(H,26,27,28,30) KIQWHSXCLUTZKG-UHFFFAOYSA-N 132517 US8841312, 266 Cyclin-dependent kinase 6 Homo sapiens 6.5 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132517&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300027 242055483 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265427 O=S1(=O)CCC(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C24H26N6O2S/c31-33(32)11-8-16(9-12-33)17-5-6-22(26-13-17)28-24-27-14-20-19-7-10-25-15-21(19)30(23(20)29-24)18-3-1-2-4-18/h5-7,10,13-16,18H,1-4,8-9,11-12H2,(H,26,27,28,29) LFEZAGQLYZHSRW-UHFFFAOYSA-N 132521 US8841312, 270 Cyclin-dependent kinase 6 Homo sapiens 35 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132521&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299998 242055487 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265428 Fc1nccc2c3cnc(Nc4ccc(cn4)C4=CCS(=O)(=O)CC4)nc3n(C3CCCC3)c12 InChI=1S/C24H23FN6O2S/c25-22-21-18(7-10-26-22)19-14-28-24(30-23(19)31(21)17-3-1-2-4-17)29-20-6-5-16(13-27-20)15-8-11-34(32,33)12-9-15/h5-8,10,13-14,17H,1-4,9,11-12H2,(H,27,28,29,30) LOQGMWYHNDJJBG-UHFFFAOYSA-N 132522 US8841312, 271 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132522&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299736 242055488 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265429 NC1[C@@H]2CN(C[C@H]12)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C23H25N9/c24-21-16-11-31(12-17(16)21)20-6-5-19(29-30-20)27-23-26-9-15-14-7-8-25-10-18(14)32(22(15)28-23)13-3-1-2-4-13/h5-10,13,16-17,21H,1-4,11-12,24H2,(H,26,27,28,29)/t16-,17+,21? IELILXSXGFXHAH-QRTHJKPMSA-N 132523 US8841312, 272 Cyclin-dependent kinase 6 Homo sapiens 101 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132523&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299990 242055489 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265430 CN(C)[C@H]1CCN(C1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C25H30N8/c1-31(2)19-10-12-32(16-19)18-7-8-23(27-13-18)29-25-28-14-21-20-9-11-26-15-22(20)33(24(21)30-25)17-5-3-4-6-17/h7-9,11,13-15,17,19H,3-6,10,12,16H2,1-2H3,(H,27,28,29,30)/t19-/m0/s1 GIDODEPBXGRWBW-IBGZPJMESA-N 132539 US8841312, 288 Cyclin-dependent kinase 6 Homo sapiens 40 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132539&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299877 242055505 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265431 CN(C)[C@@H]1CCN(C1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C25H30N8/c1-31(2)19-10-12-32(16-19)18-7-8-23(27-13-18)29-25-28-14-21-20-9-11-26-15-22(20)33(24(21)30-25)17-5-3-4-6-17/h7-9,11,13-15,17,19H,3-6,10,12,16H2,1-2H3,(H,27,28,29,30)/t19-/m1/s1 GIDODEPBXGRWBW-LJQANCHMSA-N 132540 US8841312, 289 Cyclin-dependent kinase 6 Homo sapiens 40 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132540&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300035 242055506 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265432 CN(C)CCCN(C)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C24H31N9/c1-31(2)13-6-14-32(3)22-10-9-21(29-30-22)27-24-26-15-19-18-11-12-25-16-20(18)33(23(19)28-24)17-7-4-5-8-17/h9-12,15-17H,4-8,13-14H2,1-3H3,(H,26,27,28,29) HXRJRZOYIVDQKX-UHFFFAOYSA-N 132541 US8841312, 290 Cyclin-dependent kinase 6 Homo sapiens 85 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132541&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299804 242055507 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265433 CN(CCO)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C21H24N8O/c1-28(10-11-30)19-7-6-18(26-27-19)24-21-23-12-16-15-8-9-22-13-17(15)29(20(16)25-21)14-4-2-3-5-14/h6-9,12-14,30H,2-5,10-11H2,1H3,(H,23,24,25,26) HFYYJLJETVWZJA-UHFFFAOYSA-N 132542 US8841312, 291 Cyclin-dependent kinase 6 Homo sapiens 6.9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132542&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299839 242055508 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265434 OCCNc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C20H22N8O/c29-10-9-22-17-5-6-18(27-26-17)24-20-23-11-15-14-7-8-21-12-16(14)28(19(15)25-20)13-3-1-2-4-13/h5-8,11-13,29H,1-4,9-10H2,(H,22,26)(H,23,24,25,27) CMJZCKLIKVXHRH-UHFFFAOYSA-N 132543 US8841312, 292 Cyclin-dependent kinase 6 Homo sapiens 16.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132543&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299835 242055509 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265435 C[C@@H](O)CNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C21H24N8O/c1-13(30)10-23-18-6-7-19(28-27-18)25-21-24-11-16-15-8-9-22-12-17(15)29(20(16)26-21)14-4-2-3-5-14/h6-9,11-14,30H,2-5,10H2,1H3,(H,23,27)(H,24,25,26,28)/t13-/m1/s1 QCXMOVSRDNYGQN-CYBMUJFWSA-N 132544 US8841312, 293 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132544&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299621 242055510 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265436 C[C@H](O)CNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C21H24N8O/c1-13(30)10-23-18-6-7-19(28-27-18)25-21-24-11-16-15-8-9-22-12-17(15)29(20(16)26-21)14-4-2-3-5-14/h6-9,11-14,30H,2-5,10H2,1H3,(H,23,27)(H,24,25,26,28)/t13-/m0/s1 QCXMOVSRDNYGQN-ZDUSSCGKSA-N 132545 US8841312, 294 Cyclin-dependent kinase 6 Homo sapiens 26 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132545&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299980 242055511 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265437 C[C@H](CO)Nc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C21H24N8O/c1-13(12-30)24-18-6-7-19(28-27-18)25-21-23-10-16-15-8-9-22-11-17(15)29(20(16)26-21)14-4-2-3-5-14/h6-11,13-14,30H,2-5,12H2,1H3,(H,24,27)(H,23,25,26,28)/t13-/m1/s1 ORNZIPBQHSHKDI-CYBMUJFWSA-N 132546 US8841312, 295 Cyclin-dependent kinase 6 Homo sapiens 33.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132546&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299595 242055512 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265438 C[C@@H](CO)Nc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C21H24N8O/c1-13(12-30)24-18-6-7-19(28-27-18)25-21-23-10-16-15-8-9-22-11-17(15)29(20(16)26-21)14-4-2-3-5-14/h6-11,13-14,30H,2-5,12H2,1H3,(H,24,27)(H,23,25,26,28)/t13-/m0/s1 ORNZIPBQHSHKDI-ZDUSSCGKSA-N 132547 US8841312, 296 Cyclin-dependent kinase 6 Homo sapiens 14 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132547&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299845 242055513 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265439 OCCCNc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C21H24N8O/c30-11-3-9-23-18-6-7-19(28-27-18)25-21-24-12-16-15-8-10-22-13-17(15)29(20(16)26-21)14-4-1-2-5-14/h6-8,10,12-14,30H,1-5,9,11H2,(H,23,27)(H,24,25,26,28) YTNZPCAMOLEZQS-UHFFFAOYSA-N 132548 US8841312, 297 Cyclin-dependent kinase 6 Homo sapiens 13 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132548&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299733 242055514 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265440 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2ccccc32)nc1 InChI=1S/C25H29N7/c1-30-12-14-31(15-13-30)19-10-11-23(26-16-19)28-25-27-17-21-20-8-4-5-9-22(20)32(24(21)29-25)18-6-2-3-7-18/h4-5,8-11,16-18H,2-3,6-7,12-15H2,1H3,(H,26,27,28,29) QGSJHTSIQFGZDV-UHFFFAOYSA-N 132549 US8841312, 298 Cyclin-dependent kinase 6 Homo sapiens 8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132549&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299781 242055515 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265441 CC1(C)CN(CCN1)c1ccc(Nc2ncc3c4ccccc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H30N8/c1-25(2)16-32(14-13-27-25)22-12-11-21(30-31-22)28-24-26-15-19-18-9-5-6-10-20(18)33(23(19)29-24)17-7-3-4-8-17/h5-6,9-12,15,17,27H,3-4,7-8,13-14,16H2,1-2H3,(H,26,28,29,30) OCPZYMHKJYHDEO-UHFFFAOYSA-N 132550 US8841312, 299 Cyclin-dependent kinase 6 Homo sapiens 34 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132550&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299650 242055516 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265442 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2ccccc32)nn1 InChI=1S/C26H32N8/c1-32(2)18-13-15-33(16-14-18)24-12-11-23(30-31-24)28-26-27-17-21-20-9-5-6-10-22(20)34(25(21)29-26)19-7-3-4-8-19/h5-6,9-12,17-19H,3-4,7-8,13-16H2,1-2H3,(H,27,28,29,30) ZFPLWUCEDGLIET-UHFFFAOYSA-N 132551 US8841312, 300 Cyclin-dependent kinase 6 Homo sapiens 48 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132551&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299909 242055517 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265443 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2ccccc32)nn1 InChI=1S/C24H28N8/c1-30-12-14-31(15-13-30)22-11-10-21(28-29-22)26-24-25-16-19-18-8-4-5-9-20(18)32(23(19)27-24)17-6-2-3-7-17/h4-5,8-11,16-17H,2-3,6-7,12-15H2,1H3,(H,25,26,27,28) WSJLJBASYBSDMI-UHFFFAOYSA-N 132552 US8841312, 301 Cyclin-dependent kinase 6 Homo sapiens 22 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132552&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300155 242055518 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265444 C[C@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccccc4n(C4CCCC4)c3n2)nn1 InChI=1S/C24H28N8/c1-16-15-31(13-12-25-16)22-11-10-21(29-30-22)27-24-26-14-19-18-8-4-5-9-20(18)32(23(19)28-24)17-6-2-3-7-17/h4-5,8-11,14,16-17,25H,2-3,6-7,12-13,15H2,1H3,(H,26,27,28,29)/t16-/m0/s1 KHDFBLMRVOKCMV-INIZCTEOSA-N 132553 US8841312, 302 Cyclin-dependent kinase 6 Homo sapiens 23 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132553&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300160 242055519 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265445 CC1CN(CC(C)N1)c1ccc(Nc2ncc3c4ccccc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H31N7/c1-17-15-32(16-18(2)29-17)20-11-12-24(27-13-20)30-26-28-14-22-21-9-5-6-10-23(21)33(25(22)31-26)19-7-3-4-8-19/h5-6,9-14,17-19,29H,3-4,7-8,15-16H2,1-2H3,(H,27,28,30,31) LTQWMHQCZKPWSG-UHFFFAOYSA-N 132554 US8841312, 303 Cyclin-dependent kinase 6 Homo sapiens 30 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132554&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300195 242055520 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265446 O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2ccccc32)nc1 InChI=1S/C24H26N6O/c31-18-11-12-29(15-18)17-9-10-22(25-13-17)27-24-26-14-20-19-7-3-4-8-21(19)30(23(20)28-24)16-5-1-2-6-16/h3-4,7-10,13-14,16,18,31H,1-2,5-6,11-12,15H2,(H,25,26,27,28)/t18-/m1/s1 CUOAKASSZZNNNL-GOSISDBHSA-N 132555 US8841312, 304 Cyclin-dependent kinase 6 Homo sapiens 27 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132555&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299612 242055521 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265447 O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2ccccc32)nc1 InChI=1S/C24H26N6O/c31-18-11-12-29(15-18)17-9-10-22(25-13-17)27-24-26-14-20-19-7-3-4-8-21(19)30(23(20)28-24)16-5-1-2-6-16/h3-4,7-10,13-14,16,18,31H,1-2,5-6,11-12,15H2,(H,25,26,27,28)/t18-/m0/s1 CUOAKASSZZNNNL-SFHVURJKSA-N 132556 US8841312, 305 Cyclin-dependent kinase 6 Homo sapiens 111 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132556&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299829 242055522 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265448 CC1CN(CC(C)N1)c1ccc(Nc2ncc3c4ccccc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H30N8/c1-16-14-32(15-17(2)27-16)23-12-11-22(30-31-23)28-25-26-13-20-19-9-5-6-10-21(19)33(24(20)29-25)18-7-3-4-8-18/h5-6,9-13,16-18,27H,3-4,7-8,14-15H2,1-2H3,(H,26,28,29,30) WTYQQWZPWDYEMU-UHFFFAOYSA-N 132557 US8841312, 306 Cyclin-dependent kinase 6 Homo sapiens 39 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132557&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299715 242055523 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265449 C1CCC(C1)n1c2ccccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 InChI=1S/C23H26N8/c1-2-6-16(5-1)31-19-8-4-3-7-17(19)18-15-25-23(27-22(18)31)26-20-9-10-21(29-28-20)30-13-11-24-12-14-30/h3-4,7-10,15-16,24H,1-2,5-6,11-14H2,(H,25,26,27,28) APKPENVZICKJOY-UHFFFAOYSA-N 132558 US8841312, 307 Cyclin-dependent kinase 6 Homo sapiens 8.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132558&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299785 242055524 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265450 NC1CCN(CC1)c1ccc(Nc2ncc3c4ccccc4n(C4CCCC4)c3n2)nn1 InChI=1S/C24H28N8/c25-16-11-13-31(14-12-16)22-10-9-21(29-30-22)27-24-26-15-19-18-7-3-4-8-20(18)32(23(19)28-24)17-5-1-2-6-17/h3-4,7-10,15-17H,1-2,5-6,11-14,25H2,(H,26,27,28,29) MPUULNLPAQHDGK-UHFFFAOYSA-N 132559 US8841312, 308 Cyclin-dependent kinase 6 Homo sapiens 8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132559&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300148 242055525 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265451 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2ccccc32)nc1 InChI=1S/C27H33N7/c1-32(2)19-13-15-33(16-14-19)21-11-12-25(28-17-21)30-27-29-18-23-22-9-5-6-10-24(22)34(26(23)31-27)20-7-3-4-8-20/h5-6,9-12,17-20H,3-4,7-8,13-16H2,1-2H3,(H,28,29,30,31) LDEHCBTUGDRPFY-UHFFFAOYSA-N 132560 US8841312, 309 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132560&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299858 242055526 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265452 CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1 InChI=1S/C25H29FN8/c1-27-16-9-12-33(13-10-16)18-6-7-21(29-14-18)31-25-30-15-20-19-8-11-28-23(26)22(19)34(24(20)32-25)17-4-2-3-5-17/h6-8,11,14-17,27H,2-5,9-10,12-13H2,1H3,(H,29,30,31,32) CFBGLJFJVCLSNN-UHFFFAOYSA-N 132561 US8841312, 310 Cyclin-dependent kinase 6 Homo sapiens 13 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132561&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300020 242055527 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265453 O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nn1 InChI=1S/C22H23FN8O/c23-20-19-15(7-9-24-20)16-11-25-22(27-21(16)31(19)13-3-1-2-4-13)26-17-5-6-18(29-28-17)30-10-8-14(32)12-30/h5-7,9,11,13-14,32H,1-4,8,10,12H2,(H,25,26,27,28)/t14-/m0/s1 KBNBMEPJGLGMRS-AWEZNQCLSA-N 132562 US8841312, 311 Cyclin-dependent kinase 6 Homo sapiens 24 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132562&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299993 242055528 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265454 COCCn1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C21H24N8O/c1-30-11-10-29-18-14-23-5-4-16(18)17-13-25-21(27-20(17)29)26-19-3-2-15(12-24-19)28-8-6-22-7-9-28/h2-5,12-14,22H,6-11H2,1H3,(H,24,25,26,27) SNSZKJPBYIHUPY-UHFFFAOYSA-N 132563 US8841312, 312 Cyclin-dependent kinase 6 Homo sapiens 790 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132563&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300114 242055529 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265455 COCCn1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 InChI=1S/C20H23N9O/c1-30-11-10-29-16-13-22-5-4-14(16)15-12-23-20(25-19(15)29)24-17-2-3-18(27-26-17)28-8-6-21-7-9-28/h2-5,12-13,21H,6-11H2,1H3,(H,23,24,25,26) URRIHRKEWFRNLT-UHFFFAOYSA-N 132564 US8841312, 313 Cyclin-dependent kinase 6 Homo sapiens 400 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132564&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299559 242055530 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265456 COCCn1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCC(CC3)N(C)C)nc12 InChI=1S/C24H30N8O/c1-30(2)17-7-10-31(11-8-17)18-4-5-22(26-14-18)28-24-27-15-20-19-6-9-25-16-21(19)32(12-13-33-3)23(20)29-24/h4-6,9,14-17H,7-8,10-13H2,1-3H3,(H,26,27,28,29) GNMDABILIBRYQY-UHFFFAOYSA-N 132565 US8841312, 314 Cyclin-dependent kinase 6 Homo sapiens 1500 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132565&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300145 242055531 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265457 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)N(C)C)nc12 InChI=1S/C24H31N9/c1-5-16(2)33-20-15-25-11-8-18(20)19-14-26-24(28-23(19)33)27-21-6-7-22(30-29-21)32-12-9-17(10-13-32)31(3)4/h6-8,11,14-17H,5,9-10,12-13H2,1-4H3,(H,26,27,28,29)/t16-/m1/s1 ULLGENQITYAYQU-MRXNPFEDSA-N 132567 US8841312, 316 Cyclin-dependent kinase 6 Homo sapiens 59 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132567&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300192 242055533 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265458 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCN[C@@H](C)C3)nc12 InChI=1S/C22H27N9/c1-4-15(3)31-18-12-23-8-7-16(18)17-11-25-22(27-21(17)31)26-19-5-6-20(29-28-19)30-10-9-24-14(2)13-30/h5-8,11-12,14-15,24H,4,9-10,13H2,1-3H3,(H,25,26,27,28)/t14-,15+/m0/s1 JZLXIDIBRQZXJD-LSDHHAIUSA-N 132568 US8841312, 317 Cyclin-dependent kinase 6 Homo sapiens 21 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132568&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299702 242055534 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265459 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)NC)nc12 InChI=1S/C23H29N9/c1-4-15(2)32-19-14-25-10-7-17(19)18-13-26-23(28-22(18)32)27-20-5-6-21(30-29-20)31-11-8-16(24-3)9-12-31/h5-7,10,13-16,24H,4,8-9,11-12H2,1-3H3,(H,26,27,28,29)/t15-/m1/s1 VCEVKRSWGMXHPO-OAHLLOKOSA-N 132569 US8841312, 318 Cyclin-dependent kinase 6 Homo sapiens 27 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132569&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300078 242055535 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265460 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CC[C@@H](O)C3)nc12 InChI=1S/C21H24N8O/c1-3-13(2)29-17-11-22-8-6-15(17)16-10-23-21(25-20(16)29)24-18-4-5-19(27-26-18)28-9-7-14(30)12-28/h4-6,8,10-11,13-14,30H,3,7,9,12H2,1-2H3,(H,23,24,25,26)/t13-,14-/m1/s1 IIIIVBPOQAVFDM-ZIAGYGMSSA-N 132570 US8841312, 319 Cyclin-dependent kinase 6 Homo sapiens 49 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132570&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300144 242055536 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265461 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C22H26N8/c1-3-15(2)30-19-14-24-7-6-17(19)18-13-26-22(28-21(18)30)27-20-5-4-16(12-25-20)29-10-8-23-9-11-29/h4-7,12-15,23H,3,8-11H2,1-2H3,(H,25,26,27,28)/t15-/m1/s1 DCLFXGXYMNQEGE-OAHLLOKOSA-N 132571 US8841312, 320 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132571&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299640 242055537 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265462 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCN[C@@H](C)C3)nc12 InChI=1S/C23H28N8/c1-4-16(3)31-20-13-24-8-7-18(20)19-12-27-23(29-22(19)31)28-21-6-5-17(11-26-21)30-10-9-25-15(2)14-30/h5-8,11-13,15-16,25H,4,9-10,14H2,1-3H3,(H,26,27,28,29)/t15-,16+/m0/s1 LFDCAGWSNIVJEU-JKSUJKDBSA-N 132572 US8841312, 321 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132572&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300089 242055538 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265463 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CC[C@@H](O)C3)nc12 InChI=1S/C22H25N7O/c1-3-14(2)29-19-12-23-8-6-17(19)18-11-25-22(27-21(18)29)26-20-5-4-15(10-24-20)28-9-7-16(30)13-28/h4-6,8,10-12,14,16,30H,3,7,9,13H2,1-2H3,(H,24,25,26,27)/t14-,16-/m1/s1 VBKQQDIWFTTXHE-GDBMZVCRSA-N 132573 US8841312, 322 Cyclin-dependent kinase 6 Homo sapiens 50 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132573&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44133067 242055539 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265464 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 InChI=1S/C21H25N9/c1-3-14(2)30-17-13-23-7-6-15(17)16-12-24-21(26-20(16)30)25-18-4-5-19(28-27-18)29-10-8-22-9-11-29/h4-7,12-14,22H,3,8-11H2,1-2H3,(H,24,25,26,27)/t14-/m1/s1 OQAXDEGUMXXBQC-CQSZACIVSA-N 132574 US8841312, 323 Cyclin-dependent kinase 6 Homo sapiens 23 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132574&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300184 242055540 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265465 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNC(C)(C)C3)nc12 InChI=1S/C23H29N9/c1-5-15(2)32-18-13-24-9-8-16(18)17-12-25-22(28-21(17)32)27-19-6-7-20(30-29-19)31-11-10-26-23(3,4)14-31/h6-9,12-13,15,26H,5,10-11,14H2,1-4H3,(H,25,27,28,29)/t15-/m1/s1 CRHUKNBYXYKXBS-OAHLLOKOSA-N 132575 US8841312, 324 Cyclin-dependent kinase 6 Homo sapiens 20 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132575&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300005 242055541 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265466 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCC(CC3)NC)nc12 InChI=1S/C24H30N8/c1-4-16(2)32-21-15-26-10-7-19(21)20-14-28-24(30-23(20)32)29-22-6-5-18(13-27-22)31-11-8-17(25-3)9-12-31/h5-7,10,13-17,25H,4,8-9,11-12H2,1-3H3,(H,27,28,29,30)/t16-/m1/s1 QIQHZHDHJRCDDH-MRXNPFEDSA-N 132576 US8841312, 325 Cyclin-dependent kinase 6 Homo sapiens 42 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132576&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300119 242055542 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265467 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCC2)c2cnccc32)nc1 InChI=1S/C25H30N8/c1-31(2)17-9-12-32(13-10-17)19-6-7-23(27-14-19)29-25-28-15-21-20-8-11-26-16-22(20)33(24(21)30-25)18-4-3-5-18/h6-8,11,14-18H,3-5,9-10,12-13H2,1-2H3,(H,27,28,29,30) JFFPDPOBHVQORV-UHFFFAOYSA-N 132592 US8841312, 341 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132592&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299656 242055558 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265468 CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNC(C)(C)C3)nc12 InChI=1S/C24H30N8/c1-5-16(2)32-20-14-25-9-8-18(20)19-13-27-23(30-22(19)32)29-21-7-6-17(12-26-21)31-11-10-28-24(3,4)15-31/h6-9,12-14,16,28H,5,10-11,15H2,1-4H3,(H,26,27,29,30)/t16-/m1/s1 IWXGANKLKSELIX-MRXNPFEDSA-N 132593 US8841312, 342 Cyclin-dependent kinase 6 Homo sapiens 77 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132593&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300122 242055559 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265469 CC1(C)CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCC4)c3n2)nc1 InChI=1S/C24H28N8/c1-24(2)15-31(11-10-28-24)17-6-7-21(26-12-17)29-23-27-13-19-18-8-9-25-14-20(18)32(22(19)30-23)16-4-3-5-16/h6-9,12-14,16,28H,3-5,10-11,15H2,1-2H3,(H,26,27,29,30) AXODIUJQDFIKDJ-UHFFFAOYSA-N 132594 US8841312, 343 Cyclin-dependent kinase 6 Homo sapiens 28 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132594&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300140 242055560 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265470 C[C@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCC4)c3n2)nc1 InChI=1S/C23H26N8/c1-15-14-30(10-9-25-15)17-5-6-21(26-11-17)28-23-27-12-19-18-7-8-24-13-20(18)31(22(19)29-23)16-3-2-4-16/h5-8,11-13,15-16,25H,2-4,9-10,14H2,1H3,(H,26,27,28,29)/t15-/m0/s1 YNERHABIIHQUTQ-HNNXBMFYSA-N 132595 US8841312, 344::US8841312, 433 Cyclin-dependent kinase 6 Homo sapiens 10 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132595&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299935 242055561 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265471 CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCC4)c3n2)nc1 InChI=1S/C24H28N8/c1-25-16-8-11-31(12-9-16)18-5-6-22(27-13-18)29-24-28-14-20-19-7-10-26-15-21(19)32(23(20)30-24)17-3-2-4-17/h5-7,10,13-17,25H,2-4,8-9,11-12H2,1H3,(H,27,28,29,30) LGYATYGAQMYTGJ-UHFFFAOYSA-N 132596 US8841312, 345 Cyclin-dependent kinase 6 Homo sapiens 15 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132596&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300161 242055562 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265472 C1CC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 InChI=1S/C21H23N9/c1-2-14(3-1)30-17-13-23-7-6-15(17)16-12-24-21(26-20(16)30)25-18-4-5-19(28-27-18)29-10-8-22-9-11-29/h4-7,12-14,22H,1-3,8-11H2,(H,24,25,26,27) AOQGFYCQRQMBKO-UHFFFAOYSA-N 132597 US8841312, 346 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132597&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299676 242055563 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265473 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCC2)c2cnccc32)nn1 InChI=1S/C24H29N9/c1-31(2)16-9-12-32(13-10-16)22-7-6-21(29-30-22)27-24-26-14-19-18-8-11-25-15-20(18)33(23(19)28-24)17-4-3-5-17/h6-8,11,14-17H,3-5,9-10,12-13H2,1-2H3,(H,26,27,28,29) YEHAPGDDUMGAOD-UHFFFAOYSA-N 132598 US8841312, 347 Cyclin-dependent kinase 6 Homo sapiens 27 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132598&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299818 242055564 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265474 CC1(C)CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCC4)c3n2)nn1 InChI=1S/C23H27N9/c1-23(2)14-31(11-10-26-23)20-7-6-19(29-30-20)27-22-25-12-17-16-8-9-24-13-18(16)32(21(17)28-22)15-4-3-5-15/h6-9,12-13,15,26H,3-5,10-11,14H2,1-2H3,(H,25,27,28,29) RAFUPHSGKSPIHL-UHFFFAOYSA-N 132599 US8841312, 348 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132599&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299931 242055565 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265475 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n([C@@H]4CCNC4)c3n2)nc1 InChI=1S/C25H31N9/c1-32(2)17-7-11-33(12-8-17)18-3-4-23(28-14-18)30-25-29-15-21-20-6-10-27-16-22(20)34(24(21)31-25)19-5-9-26-13-19/h3-4,6,10,14-17,19,26H,5,7-9,11-13H2,1-2H3,(H,28,29,30,31)/t19-/m1/s1 GIAAALWHPIBJMG-LJQANCHMSA-N 132600 US8841312, 349 Cyclin-dependent kinase 6 Homo sapiens 340 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132600&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300087 242055566 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265476 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(CCCO)c3n2)nc1 InChI=1S/C24H30N8O/c1-30(2)17-7-11-31(12-8-17)18-4-5-22(26-14-18)28-24-27-15-20-19-6-9-25-16-21(19)32(10-3-13-33)23(20)29-24/h4-6,9,14-17,33H,3,7-8,10-13H2,1-2H3,(H,26,27,28,29) COWADZBACSGMBW-UHFFFAOYSA-N 132601 US8841312, 350 Cyclin-dependent kinase 6 Homo sapiens 102 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132601&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299746 242055567 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265477 C[C@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(CCCO)c3n2)nc1 InChI=1S/C22H26N8O/c1-15-14-29(9-7-24-15)16-3-4-20(25-11-16)27-22-26-12-18-17-5-6-23-13-19(17)30(8-2-10-31)21(18)28-22/h3-6,11-13,15,24,31H,2,7-10,14H2,1H3,(H,25,26,27,28)/t15-/m0/s1 HFDRYTOEWXVZHD-HNNXBMFYSA-N 132602 US8841312, 351 Cyclin-dependent kinase 6 Homo sapiens 176 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132602&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299863 242055568 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265478 OCCCn1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12 InChI=1S/C20H23N9O/c30-11-1-8-29-16-13-22-5-4-14(16)15-12-23-20(25-19(15)29)24-17-2-3-18(27-26-17)28-9-6-21-7-10-28/h2-5,12-13,21,30H,1,6-11H2,(H,23,24,25,26) CCBZMLZJNJSZDY-UHFFFAOYSA-N 132603 US8841312, 352 Cyclin-dependent kinase 6 Homo sapiens 53 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132603&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300167 242055569 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265479 OCCCn1c2cnccc2c2cnc(Nc3ccc(nn3)N3CC[C@@H](O)C3)nc12 InChI=1S/C20H22N8O2/c29-9-1-7-28-16-11-21-6-4-14(16)15-10-22-20(24-19(15)28)23-17-2-3-18(26-25-17)27-8-5-13(30)12-27/h2-4,6,10-11,13,29-30H,1,5,7-9,12H2,(H,22,23,24,25)/t13-/m1/s1 HRCYPBKRTCCYMF-CYBMUJFWSA-N 132604 US8841312, 353 Cyclin-dependent kinase 6 Homo sapiens 103 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132604&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299756 242055570 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265480 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n([C@H]4CCC[C@H]4O)c3n2)nc1 InChI=1S/C26H32N8O/c1-32(2)17-9-12-33(13-10-17)18-6-7-24(28-14-18)30-26-29-15-20-19-8-11-27-16-22(19)34(25(20)31-26)21-4-3-5-23(21)35/h6-8,11,14-17,21,23,35H,3-5,9-10,12-13H2,1-2H3,(H,28,29,30,31)/t21-,23+/m0/s1 HKTDZTIJYNTRCQ-JTHBVZDNSA-N 132605 US8841312, 354 Cyclin-dependent kinase 6 Homo sapiens 830 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132605&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299973 242055571 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265481 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n([C@H]4CCC[C@H]4O)c3n2)nn1 InChI=1S/C25H31N9O/c1-32(2)16-9-12-33(13-10-16)23-7-6-22(30-31-23)28-25-27-14-18-17-8-11-26-15-20(17)34(24(18)29-25)19-4-3-5-21(19)35/h6-8,11,14-16,19,21,35H,3-5,9-10,12-13H2,1-2H3,(H,27,28,29,30)/t19-,21+/m0/s1 VEBWDBXHNZZYSO-PZJWPPBQSA-N 132606 US8841312, 355 Cyclin-dependent kinase 6 Homo sapiens 275 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132606&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300150 242055572 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265482 C[C@@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C21H24N8O/c1-14(30)13-29-18-12-23-5-4-16(18)17-11-25-21(27-20(17)29)26-19-3-2-15(10-24-19)28-8-6-22-7-9-28/h2-5,10-12,14,22,30H,6-9,13H2,1H3,(H,24,25,26,27)/t14-/m1/s1 NSJFZIYYYKMTMJ-CQSZACIVSA-N 132607 US8841312, 356 Cyclin-dependent kinase 6 Homo sapiens 370 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132607&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299963 242055573 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265483 C[C@@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCC(CC3)N(C)C)nc12 InChI=1S/C24H30N8O/c1-16(33)15-32-21-14-25-9-6-19(21)20-13-27-24(29-23(20)32)28-22-5-4-18(12-26-22)31-10-7-17(8-11-31)30(2)3/h4-6,9,12-14,16-17,33H,7-8,10-11,15H2,1-3H3,(H,26,27,28,29)/t16-/m1/s1 GLEPOVWXFFRWSW-MRXNPFEDSA-N 132608 US8841312, 357 Cyclin-dependent kinase 6 Homo sapiens 314 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132608&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299577 242055574 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265484 C[C@@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(cn3)N3CC[C@@H](O)C3)nc12 InChI=1S/C21H23N7O2/c1-13(29)11-28-18-10-22-6-4-16(18)17-9-24-21(26-20(17)28)25-19-3-2-14(8-23-19)27-7-5-15(30)12-27/h2-4,6,8-10,13,15,29-30H,5,7,11-12H2,1H3,(H,23,24,25,26)/t13-,15-/m1/s1 PAJDGKAXRPLQSA-UKRRQHHQSA-N 132609 US8841312, 358 Cyclin-dependent kinase 6 Homo sapiens 590 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132609&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299947 242055575 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265485 O[C@@H]1CCC[C@@H]1n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C23H26N8O/c32-20-3-1-2-18(20)31-19-14-25-7-6-16(19)17-13-27-23(29-22(17)31)28-21-5-4-15(12-26-21)30-10-8-24-9-11-30/h4-7,12-14,18,20,24,32H,1-3,8-11H2,(H,26,27,28,29)/t18-,20+/m0/s1 MAZYMHDZBKSRMW-AZUAARDMSA-N 132612 US8841312, 361 Cyclin-dependent kinase 6 Homo sapiens 58 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132612&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299720 242055578 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265486 C[C@@H](CO)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12 InChI=1S/C21H24N8O/c1-14(13-30)29-18-12-23-5-4-16(18)17-11-25-21(27-20(17)29)26-19-3-2-15(10-24-19)28-8-6-22-7-9-28/h2-5,10-12,14,22,30H,6-9,13H2,1H3,(H,24,25,26,27)/t14-/m0/s1 KDIKLUVXDINZHL-AWEZNQCLSA-N 50001534 CHEMBL3237449::US8841312, 369 Cyclin-dependent kinase 6 Homo sapiens 29 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001534&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300031 242055954 CHEMBL3237449 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265487 C[C@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCC4)c3n2)nc1 InChI=1S/C23H26N8/c1-15-14-30(10-9-25-15)17-5-6-21(26-11-17)28-23-27-12-19-18-7-8-24-13-20(18)31(22(19)29-23)16-3-2-4-16/h5-8,11-13,15-16,25H,2-4,9-10,14H2,1H3,(H,26,27,28,29)/t15-/m0/s1 YNERHABIIHQUTQ-HNNXBMFYSA-N 132595 US8841312, 344::US8841312, 433 Cyclin-dependent kinase 6 Homo sapiens 80 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132595&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299935 242055561 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265488 CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCC4)c3n2)nn1 InChI=1S/C23H27N9/c1-24-15-8-11-31(12-9-15)21-6-5-20(29-30-21)27-23-26-13-18-17-7-10-25-14-19(17)32(22(18)28-23)16-3-2-4-16/h5-7,10,13-16,24H,2-4,8-9,11-12H2,1H3,(H,26,27,28,29) CEBQAEVICMUFAY-UHFFFAOYSA-N 132684 US8841312, 434 Cyclin-dependent kinase 6 Homo sapiens 19 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132684&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300146 242055649 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265489 O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c4ccncc4n(C4CCC4)c3n2)nc1 InChI=1S/C22H23N7O/c30-16-7-9-28(13-16)15-4-5-20(24-10-15)26-22-25-11-18-17-6-8-23-12-19(17)29(21(18)27-22)14-2-1-3-14/h4-6,8,10-12,14,16,30H,1-3,7,9,13H2,(H,24,25,26,27)/t16-/m1/s1 KCVLUTIUWHAOLI-MRXNPFEDSA-N 132685 US8841312, 435 Cyclin-dependent kinase 6 Homo sapiens 92 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132685&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300091 242055650 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265490 C[C@H](CO)NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H34N8O/c1-18(17-36)31-19-9-12-34(13-10-19)21-6-7-25(29-14-21)32-27-30-15-23-22-8-11-28-16-24(22)35(26(23)33-27)20-4-2-3-5-20/h6-8,11,14-16,18-20,31,36H,2-5,9-10,12-13,17H2,1H3,(H,29,30,32,33)/t18-/m1/s1 SISAEGSKELJSQO-GOSISDBHSA-N 132686 US8841312, 436 Cyclin-dependent kinase 6 Homo sapiens 5.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132686&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299946 242055651 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265491 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)N3CCCC3)nc12 InChI=1S/C27H33N9/c1-2-6-20(5-1)36-23-18-28-12-9-21(23)22-17-29-27(31-26(22)36)30-24-7-8-25(33-32-24)35-15-10-19(11-16-35)34-13-3-4-14-34/h7-9,12,17-20H,1-6,10-11,13-16H2,(H,29,30,31,32) ZZUHVLBKVYTZJN-UHFFFAOYSA-N 132687 US8841312, 437 Cyclin-dependent kinase 6 Homo sapiens 30 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132687&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300051 242055652 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265492 OCCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H31N9O/c35-14-11-27-17-8-12-33(13-9-17)23-6-5-22(31-32-23)29-25-28-15-20-19-7-10-26-16-21(19)34(24(20)30-25)18-3-1-2-4-18/h5-7,10,15-18,27,35H,1-4,8-9,11-14H2,(H,28,29,30,31) BKEWGDSMEXIHJD-UHFFFAOYSA-N 132688 US8841312, 438 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132688&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299970 242055653 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265493 C[C@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O/c1-17(36)14-28-18-9-12-34(13-10-18)24-7-6-23(32-33-24)30-26-29-15-21-20-8-11-27-16-22(20)35(25(21)31-26)19-4-2-3-5-19/h6-8,11,15-19,28,36H,2-5,9-10,12-14H2,1H3,(H,29,30,31,32)/t17-/m0/s1 SKRUYIPFBIYOHZ-KRWDZBQOSA-N 132689 US8841312, 439 Cyclin-dependent kinase 6 Homo sapiens 5.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132689&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300173 242055654 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265494 CN(CCO)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O/c1-33(14-15-36)18-9-12-34(13-10-18)24-7-6-23(31-32-24)29-26-28-16-21-20-8-11-27-17-22(20)35(25(21)30-26)19-4-2-3-5-19/h6-8,11,16-19,36H,2-5,9-10,12-15H2,1H3,(H,28,29,30,31) MDDQGEIMRPZKBT-UHFFFAOYSA-N 132690 US8841312, 440 Cyclin-dependent kinase 6 Homo sapiens 14 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132690&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299584 242055655 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265495 C[C@@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O/c1-17(36)14-28-18-9-12-34(13-10-18)24-7-6-23(32-33-24)30-26-29-15-21-20-8-11-27-16-22(20)35(25(21)31-26)19-4-2-3-5-19/h6-8,11,15-19,28,36H,2-5,9-10,12-14H2,1H3,(H,29,30,31,32)/t17-/m1/s1 SKRUYIPFBIYOHZ-QGZVFWFLSA-N 132691 US8841312, 441 Cyclin-dependent kinase 6 Homo sapiens 3.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132691&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300200 242055656 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265496 C[C@@H](CO)NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O/c1-17(16-36)29-18-9-12-34(13-10-18)24-7-6-23(32-33-24)30-26-28-14-21-20-8-11-27-15-22(20)35(25(21)31-26)19-4-2-3-5-19/h6-8,11,14-15,17-19,29,36H,2-5,9-10,12-13,16H2,1H3,(H,28,30,31,32)/t17-/m0/s1 NRMCNHRZOLZAMB-KRWDZBQOSA-N 132692 US8841312, 442 Cyclin-dependent kinase 6 Homo sapiens 13 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132692&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299752 242055657 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265497 CNCCN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C27H36N10/c1-28-13-16-35(2)19-10-14-36(15-11-19)25-8-7-24(33-34-25)31-27-30-17-22-21-9-12-29-18-23(21)37(26(22)32-27)20-5-3-4-6-20/h7-9,12,17-20,28H,3-6,10-11,13-16H2,1-2H3,(H,30,31,32,33) CMTNNQFGCHCRSZ-UHFFFAOYSA-N 132693 US8841312, 443 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132693&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300065 242055658 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265498 C[C@H](CO)NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O/c1-17(16-36)29-18-9-12-34(13-10-18)24-7-6-23(32-33-24)30-26-28-14-21-20-8-11-27-15-22(20)35(25(21)31-26)19-4-2-3-5-19/h6-8,11,14-15,17-19,29,36H,2-5,9-10,12-13,16H2,1H3,(H,28,30,31,32)/t17-/m1/s1 NRMCNHRZOLZAMB-QGZVFWFLSA-N 132694 US8841312, 444 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132694&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300062 242055659 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265499 OCC(CO)NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O2/c36-15-18(16-37)29-17-8-11-34(12-9-17)24-6-5-23(32-33-24)30-26-28-13-21-20-7-10-27-14-22(20)35(25(21)31-26)19-3-1-2-4-19/h5-7,10,13-14,17-19,29,36-37H,1-4,8-9,11-12,15-16H2,(H,28,30,31,32) KNRZSSHNVWPHLG-UHFFFAOYSA-N 132695 US8841312, 445 Cyclin-dependent kinase 6 Homo sapiens 6.3 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132695&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300182 242055660 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265500 OC[C@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O2/c36-16-19(37)13-28-17-8-11-34(12-9-17)24-6-5-23(32-33-24)30-26-29-14-21-20-7-10-27-15-22(20)35(25(21)31-26)18-3-1-2-4-18/h5-7,10,14-15,17-19,28,36-37H,1-4,8-9,11-13,16H2,(H,29,30,31,32)/t19-/m1/s1 MLLWORSXSDVTQA-LJQANCHMSA-N 132696 US8841312, 446 Cyclin-dependent kinase 6 Homo sapiens 4.8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132696&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299730 242055661 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265501 C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC(CC3)N3CCOCC3)nc12 InChI=1S/C27H33N9O/c1-2-4-20(3-1)36-23-18-28-10-7-21(23)22-17-29-27(31-26(22)36)30-24-5-6-25(33-32-24)35-11-8-19(9-12-35)34-13-15-37-16-14-34/h5-7,10,17-20H,1-4,8-9,11-16H2,(H,29,30,31,32) UEQPGBQDKMIYEQ-UHFFFAOYSA-N 132697 US8841312, 447 Cyclin-dependent kinase 6 Homo sapiens 26 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132697&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299592 242055662 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265502 OC1CN(C1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H31N9O/c36-19-15-34(16-19)17-8-11-33(12-9-17)24-6-5-23(31-32-24)29-26-28-13-21-20-7-10-27-14-22(20)35(25(21)30-26)18-3-1-2-4-18/h5-7,10,13-14,17-19,36H,1-4,8-9,11-12,15-16H2,(H,28,29,30,31) XJDGXENWWHQUCX-UHFFFAOYSA-N 132698 US8841312, 448 Cyclin-dependent kinase 6 Homo sapiens 22 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132698&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299628 242055663 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265503 O[C@@H]1CCN(C1)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C27H33N9O/c37-20-10-14-35(17-20)18-8-12-34(13-9-18)25-6-5-24(32-33-25)30-27-29-15-22-21-7-11-28-16-23(21)36(26(22)31-27)19-3-1-2-4-19/h5-7,11,15-16,18-20,37H,1-4,8-10,12-14,17H2,(H,29,30,31,32)/t20-/m1/s1 BAMUDEHGCAVPNN-HXUWFJFHSA-N 132699 US8841312, 449 Cyclin-dependent kinase 6 Homo sapiens 36 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132699&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300096 242055664 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265504 O[C@H]1CCN(C1)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C27H33N9O/c37-20-10-14-35(17-20)18-8-12-34(13-9-18)25-6-5-24(32-33-25)30-27-29-15-22-21-7-11-28-16-23(21)36(26(22)31-27)19-3-1-2-4-19/h5-7,11,15-16,18-20,37H,1-4,8-10,12-14,17H2,(H,29,30,31,32)/t20-/m0/s1 BAMUDEHGCAVPNN-FQEVSTJZSA-N 132700 US8841312, 450 Cyclin-dependent kinase 6 Homo sapiens 16 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132700&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300159 242055665 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265505 O[C@@H]1CCCN(C1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C28H35N9O/c38-21-6-3-13-36(18-21)19-10-14-35(15-11-19)26-8-7-25(33-34-26)31-28-30-16-23-22-9-12-29-17-24(22)37(27(23)32-28)20-4-1-2-5-20/h7-9,12,16-17,19-21,38H,1-6,10-11,13-15,18H2,(H,30,31,32,33)/t21-/m1/s1 PPJRGLDUXCYWQR-OAQYLSRUSA-N 132701 US8841312, 451 Cyclin-dependent kinase 6 Homo sapiens 18 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132701&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299743 242055666 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265506 O[C@H]1CCCN(C1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C28H35N9O/c38-21-6-3-13-36(18-21)19-10-14-35(15-11-19)26-8-7-25(33-34-26)31-28-30-16-23-22-9-12-29-17-24(22)37(27(23)32-28)20-4-1-2-5-20/h7-9,12,16-17,19-21,38H,1-6,10-11,13-15,18H2,(H,30,31,32,33)/t21-/m0/s1 PPJRGLDUXCYWQR-NRFANRHFSA-N 132702 US8841312, 452 Cyclin-dependent kinase 6 Homo sapiens 30 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132702&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299611 242055667 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265507 OCCCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O/c36-15-3-11-28-18-9-13-34(14-10-18)24-7-6-23(32-33-24)30-26-29-16-21-20-8-12-27-17-22(20)35(25(21)31-26)19-4-1-2-5-19/h6-8,12,16-19,28,36H,1-5,9-11,13-15H2,(H,29,30,31,32) RUYVBOROXISBTA-UHFFFAOYSA-N 132703 US8841312, 453 Cyclin-dependent kinase 6 Homo sapiens 13 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132703&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300141 242055668 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265508 CCN(CCO)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C27H35N9O/c1-2-34(15-16-37)19-10-13-35(14-11-19)25-8-7-24(32-33-25)30-27-29-17-22-21-9-12-28-18-23(21)36(26(22)31-27)20-5-3-4-6-20/h7-9,12,17-20,37H,2-6,10-11,13-16H2,1H3,(H,29,30,31,32) LMQLCRSBIMGSIN-UHFFFAOYSA-N 132704 US8841312, 454 Cyclin-dependent kinase 6 Homo sapiens 11 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132704&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300084 242055669 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265509 OC1CCN(CC1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C28H35N9O/c38-21-10-15-35(16-11-21)19-8-13-36(14-9-19)26-6-5-25(33-34-26)31-28-30-17-23-22-7-12-29-18-24(22)37(27(23)32-28)20-3-1-2-4-20/h5-7,12,17-21,38H,1-4,8-11,13-16H2,(H,30,31,32,33) DXKQFNWEGVJNQT-UHFFFAOYSA-N 132705 US8841312, 455 Cyclin-dependent kinase 6 Homo sapiens 9 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132705&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299891 242055670 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265510 FC(F)(F)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H28F3N9/c26-25(27,28)15-31-16-8-11-36(12-9-16)22-6-5-21(34-35-22)32-24-30-13-19-18-7-10-29-14-20(18)37(23(19)33-24)17-3-1-2-4-17/h5-7,10,13-14,16-17,31H,1-4,8-9,11-12,15H2,(H,30,32,33,34) LVKJKRHVKKFITG-UHFFFAOYSA-N 132706 US8841312, 456 Cyclin-dependent kinase 6 Homo sapiens 380 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132706&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300157 242055671 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265511 CN(CCO)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H34N8O/c1-33(14-15-36)19-9-12-34(13-10-19)21-6-7-25(29-16-21)31-27-30-17-23-22-8-11-28-18-24(22)35(26(23)32-27)20-4-2-3-5-20/h6-8,11,16-20,36H,2-5,9-10,12-15H2,1H3,(H,29,30,31,32) AVLXLHMRMWGCNQ-UHFFFAOYSA-N 132707 US8841312, 457 Cyclin-dependent kinase 6 Homo sapiens 37 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132707&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299705 242055672 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265512 OCCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H32N8O/c35-14-11-28-18-8-12-33(13-9-18)20-5-6-24(29-15-20)31-26-30-16-22-21-7-10-27-17-23(21)34(25(22)32-26)19-3-1-2-4-19/h5-7,10,15-19,28,35H,1-4,8-9,11-14H2,(H,29,30,31,32) OBTPCSNROCZPDN-UHFFFAOYSA-N 132708 US8841312, 458 Cyclin-dependent kinase 6 Homo sapiens 5.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132708&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300180 242055673 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265513 C[C@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H34N8O/c1-18(36)14-29-19-9-12-34(13-10-19)21-6-7-25(30-15-21)32-27-31-16-23-22-8-11-28-17-24(22)35(26(23)33-27)20-4-2-3-5-20/h6-8,11,15-20,29,36H,2-5,9-10,12-14H2,1H3,(H,30,31,32,33)/t18-/m0/s1 ZEKYDJPVMYFVGA-SFHVURJKSA-N 132709 US8841312, 459 Cyclin-dependent kinase 6 Homo sapiens 14 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132709&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300049 242055674 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265514 C[C@@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H34N8O/c1-18(36)14-29-19-9-12-34(13-10-19)21-6-7-25(30-15-21)32-27-31-16-23-22-8-11-28-17-24(22)35(26(23)33-27)20-4-2-3-5-20/h6-8,11,15-20,29,36H,2-5,9-10,12-14H2,1H3,(H,30,31,32,33)/t18-/m1/s1 ZEKYDJPVMYFVGA-GOSISDBHSA-N 132710 US8841312, 460::US8841312, 461 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132710&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299941 242055675 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265515 C[C@@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H34N8O/c1-18(36)14-29-19-9-12-34(13-10-19)21-6-7-25(30-15-21)32-27-31-16-23-22-8-11-28-17-24(22)35(26(23)33-27)20-4-2-3-5-20/h6-8,11,15-20,29,36H,2-5,9-10,12-14H2,1H3,(H,30,31,32,33)/t18-/m1/s1 ZEKYDJPVMYFVGA-GOSISDBHSA-N 132710 US8841312, 460::US8841312, 461 Cyclin-dependent kinase 6 Homo sapiens 119 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132710&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299941 242055675 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265516 O[C@H]1CCN(C1)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C28H34N8O/c37-22-10-14-35(18-22)19-8-12-34(13-9-19)21-5-6-26(30-15-21)32-28-31-16-24-23-7-11-29-17-25(23)36(27(24)33-28)20-3-1-2-4-20/h5-7,11,15-17,19-20,22,37H,1-4,8-10,12-14,18H2,(H,30,31,32,33)/t22-/m0/s1 DEXZHKNXZYDRKP-QFIPXVFZSA-N 132712 US8841312, 462 Cyclin-dependent kinase 6 Homo sapiens 350 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132712&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300218 242055676 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265517 OC1CCN(CC1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C29H36N8O/c38-23-10-15-35(16-11-23)20-8-13-36(14-9-20)22-5-6-27(31-17-22)33-29-32-18-25-24-7-12-30-19-26(24)37(28(25)34-29)21-3-1-2-4-21/h5-7,12,17-21,23,38H,1-4,8-11,13-16H2,(H,31,32,33,34) SKOIAGWEQCETAF-UHFFFAOYSA-N 132713 US8841312, 463 Cyclin-dependent kinase 6 Homo sapiens 18 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132713&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299637 242055677 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265518 CCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H32N8/c1-2-28-18-10-13-33(14-11-18)20-7-8-24(29-15-20)31-26-30-16-22-21-9-12-27-17-23(21)34(25(22)32-26)19-5-3-4-6-19/h7-9,12,15-19,28H,2-6,10-11,13-14H2,1H3,(H,29,30,31,32) ZURIPGCQHWFPSQ-UHFFFAOYSA-N 132714 US8841312, 464 Cyclin-dependent kinase 6 Homo sapiens 3.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132714&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300032 242055678 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265519 C1CC1NC1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C27H32N8/c1-2-4-20(3-1)35-24-17-28-12-9-22(24)23-16-30-27(33-26(23)35)32-25-8-7-21(15-29-25)34-13-10-19(11-14-34)31-18-5-6-18/h7-9,12,15-20,31H,1-6,10-11,13-14H2,(H,29,30,32,33) QXFDGSVFDQJMHD-UHFFFAOYSA-N 132715 US8841312, 465 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132715&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299809 242055679 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265520 CCCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H34N8/c1-2-12-29-19-10-14-34(15-11-19)21-7-8-25(30-16-21)32-27-31-17-23-22-9-13-28-18-24(22)35(26(23)33-27)20-5-3-4-6-20/h7-9,13,16-20,29H,2-6,10-12,14-15H2,1H3,(H,30,31,32,33) HXYNOSRTKCYTLX-UHFFFAOYSA-N 132716 US8841312, 466 Cyclin-dependent kinase 6 Homo sapiens 14 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132716&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299700 242055680 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265521 FCCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H31FN8/c27-10-12-29-18-8-13-34(14-9-18)20-5-6-24(30-15-20)32-26-31-16-22-21-7-11-28-17-23(21)35(25(22)33-26)19-3-1-2-4-19/h5-7,11,15-19,29H,1-4,8-10,12-14H2,(H,30,31,32,33) JDUNFKKPNFKLEH-UHFFFAOYSA-N 132717 US8841312, 467 Cyclin-dependent kinase 6 Homo sapiens 21 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132717&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300129 242055681 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265522 C1CC(C1)NC1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C28H34N8/c1-2-7-21(6-1)36-25-18-29-13-10-23(25)24-17-31-28(34-27(24)36)33-26-9-8-22(16-30-26)35-14-11-20(12-15-35)32-19-4-3-5-19/h8-10,13,16-21,32H,1-7,11-12,14-15H2,(H,30,31,33,34) DRNNJQFGMPFBFK-UHFFFAOYSA-N 132718 US8841312, 468 Cyclin-dependent kinase 6 Homo sapiens 19 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132718&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299833 242055682 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265523 CC(C)NC1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C27H34N8/c1-18(2)31-19-10-13-34(14-11-19)21-7-8-25(29-15-21)32-27-30-16-23-22-9-12-28-17-24(22)35(26(23)33-27)20-5-3-4-6-20/h7-9,12,15-20,31H,3-6,10-11,13-14H2,1-2H3,(H,29,30,32,33) KHCQHSATOWGBMQ-UHFFFAOYSA-N 132719 US8841312, 469 Cyclin-dependent kinase 6 Homo sapiens 20 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132719&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300198 242055683 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265524 FC(F)(F)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H29F3N8/c27-26(28,29)16-33-17-8-11-36(12-9-17)19-5-6-23(31-13-19)34-25-32-14-21-20-7-10-30-15-22(20)37(24(21)35-25)18-3-1-2-4-18/h5-7,10,13-15,17-18,33H,1-4,8-9,11-12,16H2,(H,31,32,34,35) WFRQTWKTDYNOMW-UHFFFAOYSA-N 132720 US8841312, 470 Cyclin-dependent kinase 6 Homo sapiens 38 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132720&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300086 242055684 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265525 CN(CC(O)=O)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H32N8O2/c1-33(17-25(36)37)18-9-12-34(13-10-18)20-6-7-24(29-14-20)31-27-30-15-22-21-8-11-28-16-23(21)35(26(22)32-27)19-4-2-3-5-19/h6-8,11,14-16,18-19H,2-5,9-10,12-13,17H2,1H3,(H,36,37)(H,29,30,31,32) HVTBDBBRIIDFMN-UHFFFAOYSA-N 132721 US8841312, 471 Cyclin-dependent kinase 6 Homo sapiens 18 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132721&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300010 242055685 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265526 COC(=O)CNC1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1 InChI=1S/C27H32N8O2/c1-37-25(36)17-29-18-9-12-34(13-10-18)20-6-7-24(30-14-20)32-27-31-15-22-21-8-11-28-16-23(21)35(26(22)33-27)19-4-2-3-5-19/h6-8,11,14-16,18-19,29H,2-5,9-10,12-13,17H2,1H3,(H,30,31,32,33) JSMQRWBYWSIQRV-UHFFFAOYSA-N 132722 US8841312, 472 Cyclin-dependent kinase 6 Homo sapiens 34 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132722&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300199 242055686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265527 CCN(CCO)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C28H36N8O/c1-2-34(15-16-37)20-10-13-35(14-11-20)22-7-8-26(30-17-22)32-28-31-18-24-23-9-12-29-19-25(23)36(27(24)33-28)21-5-3-4-6-21/h7-9,12,17-21,37H,2-6,10-11,13-16H2,1H3,(H,30,31,32,33) JJJVFTNNFDYRFZ-UHFFFAOYSA-N 132723 US8841312, 473 Cyclin-dependent kinase 6 Homo sapiens 28 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132723&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299903 242055687 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265528 OC1CN(C1)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H32N8O/c36-21-16-34(17-21)18-8-11-33(12-9-18)20-5-6-25(29-13-20)31-27-30-14-23-22-7-10-28-15-24(22)35(26(23)32-27)19-3-1-2-4-19/h5-7,10,13-15,18-19,21,36H,1-4,8-9,11-12,16-17H2,(H,29,30,31,32) VKWVMZJDIBGOSR-UHFFFAOYSA-N 132724 US8841312, 474 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132724&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300099 242055688 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265529 C[C@@H](CO)NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C27H34N8O/c1-18(17-36)31-19-9-12-34(13-10-19)21-6-7-25(29-14-21)32-27-30-15-23-22-8-11-28-16-24(22)35(26(23)33-27)20-4-2-3-5-20/h6-8,11,14-16,18-20,31,36H,2-5,9-10,12-13,17H2,1H3,(H,29,30,32,33)/t18-/m0/s1 SISAEGSKELJSQO-SFHVURJKSA-N 132725 US8841312, 475 Cyclin-dependent kinase 6 Homo sapiens 8 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132725&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299918 242055689 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265530 COC(=O)CNC1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 InChI=1S/C26H31N9O2/c1-37-24(36)16-28-17-9-12-34(13-10-17)23-7-6-22(32-33-23)30-26-29-14-20-19-8-11-27-15-21(19)35(25(20)31-26)18-4-2-3-5-18/h6-8,11,14-15,17-18,28H,2-5,9-10,12-13,16H2,1H3,(H,29,30,31,32) GKYNYPYSGJOBRE-UHFFFAOYSA-N 132726 US8841312, 476 Cyclin-dependent kinase 6 Homo sapiens 26 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132726&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299925 242055690 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265531 OC(=O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 InChI=1S/C26H30N8O2/c35-24(36)16-28-17-8-11-33(12-9-17)19-5-6-23(29-13-19)31-26-30-14-21-20-7-10-27-15-22(20)34(25(21)32-26)18-3-1-2-4-18/h5-7,10,13-15,17-18,28H,1-4,8-9,11-12,16H2,(H,35,36)(H,29,30,31,32) ZRBMKKBZXGSURN-UHFFFAOYSA-N 132727 US8841312, 477 Cyclin-dependent kinase 6 Homo sapiens 5.1 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132727&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300156 242055691 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265532 OC(=O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C25H29N9O2/c35-23(36)15-27-16-8-11-33(12-9-16)22-6-5-21(31-32-22)29-25-28-13-19-18-7-10-26-14-20(18)34(24(19)30-25)17-3-1-2-4-17/h5-7,10,13-14,16-17,27H,1-4,8-9,11-12,15H2,(H,35,36)(H,28,29,30,31) NROJANSVZVKJQE-UHFFFAOYSA-N 132728 US8841312, 478 Cyclin-dependent kinase 6 Homo sapiens 5.7 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132728&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58299616 242055692 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265533 CN(C)CCN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C28H38N10/c1-35(2)16-17-36(3)20-11-14-37(15-12-20)26-9-8-25(33-34-26)31-28-30-18-23-22-10-13-29-19-24(22)38(27(23)32-28)21-6-4-5-7-21/h8-10,13,18-21H,4-7,11-12,14-17H2,1-3H3,(H,30,31,32,33) XUPRCCLLUPDTDK-UHFFFAOYSA-N 132729 US8841312, 479 Cyclin-dependent kinase 6 Homo sapiens 17 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132729&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300001 242055693 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265534 CN(C)CCNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C27H36N10/c1-35(2)16-13-29-19-10-14-36(15-11-19)25-8-7-24(33-34-25)31-27-30-17-22-21-9-12-28-18-23(21)37(26(22)32-27)20-5-3-4-6-20/h7-9,12,17-20,29H,3-6,10-11,13-16H2,1-2H3,(H,30,31,32,33) DPIODVZRGWTHFY-UHFFFAOYSA-N 132730 US8841312, 480 Cyclin-dependent kinase 6 Homo sapiens 10 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132730&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300201 242055694 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 265535 OC[C@@H](O)CNC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 InChI=1S/C26H33N9O2/c36-16-19(37)13-28-17-8-11-34(12-9-17)24-6-5-23(32-33-24)30-26-29-14-21-20-7-10-27-15-22(20)35(25(21)31-26)18-3-1-2-4-18/h5-7,10,14-15,17-19,28,36-37H,1-4,8-9,11-13,16H2,(H,29,30,31,32)/t19-/m0/s1 MLLWORSXSDVTQA-IBGZPJMESA-N 132731 US8841312, 481 Cyclin-dependent kinase 6 Homo sapiens 12 7.4 37.00 C US Patent 10.7270/Q2H41Q4H aid1800678 US8841312 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=132731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=132731&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 58300052 242055695 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 273855 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(Sc2ccc(F)cc2)c1=O InChI=1S/C22H16FN5OS/c1-28-20-14(11-19(21(28)29)30-17-5-2-15(23)3-6-17)12-25-22(27-20)26-16-4-7-18-13(10-16)8-9-24-18/h2-12,24H,1H3,(H,25,26,27) FJECSOOLAWUZAB-UHFFFAOYSA-N 139539 US8889696, 39 Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q2930RVR aid1800772 US8889696 Reddy, EP; Reddy, MV Temple University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139539&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 70895719 249871007 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 273888 CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 YISMQBFJYDFMAL-AESIHLKFSA-N 139540 US10189849, staurosporine::US10307427, Staurosporine::US10329300, Staurosporine::US11091485, Compound Staurosporine::US11542261, Compound staurosporine::US8889696, Staurosporine::US9051313, Staurosporine::US9586965, Control Staurosporine Cyclin-dependent kinase 6 Homo sapiens 242.6 US Patent 10.7270/Q2930RVR aid1800772 US8889696 Reddy, EP; Reddy, MV Temple University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139540&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 91669270 249871008 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 308352 COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 InChI=1S/C21H24FN3O3/c1-13(26)24-17-5-3-4-15(10-17)21(27)25-20-11-14(8-9-23-20)18-7-6-16(22)12-19(18)28-2/h6-9,11-12,15,17H,3-5,10H2,1-2H3,(H,24,26)(H,23,25,27)/t15-,17+/m0/s1 QNWXRLPZIFMTBK-DOTOQJQBSA-N 164883 US9067888, 33 Cyclin-dependent kinase 6 Homo sapiens >5000 7.5 US Patent 10.7270/Q2CR5S4T aid1801360 US9067888 Zeitlmann, L; Niestroj, A; Heiser, U AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164883&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 53373586 311419854 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 308353 COc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(C2)NC(C)=O)c1 InChI=1S/C20H22FN3O3/c1-12(25)23-16-5-3-14(9-16)20(26)24-19-10-13(7-8-22-19)17-6-4-15(21)11-18(17)27-2/h4,6-8,10-11,14,16H,3,5,9H2,1-2H3,(H,23,25)(H,22,24,26) FUMJKSZLZJFCAQ-UHFFFAOYSA-N 164884 US9067888, 34 Cyclin-dependent kinase 6 Homo sapiens >5000 7.5 US Patent 10.7270/Q2CR5S4T aid1801360 US9067888 Zeitlmann, L; Niestroj, A; Heiser, U AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164884&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 76029028 311419855 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50152379 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-dependent kinase 6 Homo sapiens 116 ChEMBL 10.1021/jm801317h 10.7270/Q24M94FZ 19338355 Gaisina, IN; Gallier, F; Ougolkov, AV; Kim, KH; Kurome, T; Guo, S; Holzle, D; Luchini, DN; Blond, SY; Billadeau, DD; Kozikowski, AP University of Illinois at Chicago http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50244401 CC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CN1CC[C@H](C1)C(=O)Nc1ccc(O)c(Cl)c1 InChI=1S/C25H29ClN4O4/c1-17(31)18-2-5-21(6-3-18)29-10-12-30(13-11-29)24(33)16-28-9-8-19(15-28)25(34)27-20-4-7-23(32)22(26)14-20/h2-7,14,19,32H,8-13,15-16H2,1H3,(H,27,34)/t19-/m1/s1 YPNCCYRKEHPJMN-LJQANCHMSA-N 50030881 CHEMBL3356117 Cyclin-dependent kinase 6 Homo sapiens >50000 ChEMBL 10.1021/jm500847m 10.7270/Q2Q52R6D 25313996 Deng, Y; Shipps, GW; Cooper, A; English, JM; Annis, DA; Carr, D; Nan, Y; Wang, T; Zhu, HY; Chuang, CC; Dayananth, P; Hruza, AW; Xiao, L; Jin, W; Kirschmeier, P; Windsor, WT; Samatar, AA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030881&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 3G7 4QYY 58985201 313065931 CHEMBL3356117 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50345205 CN1CCN(Cc2cnc(Nc3ncc(s3)-c3cc(C)nc(OC4CCCCC4)n3)cn2)CC1 InChI=1S/C24H32N8OS/c1-17-12-20(29-23(28-17)33-19-6-4-3-5-7-19)21-14-27-24(34-21)30-22-15-25-18(13-26-22)16-32-10-8-31(2)9-11-32/h12-15,19H,3-11,16H2,1-2H3,(H,26,27,30) DLIDUXYWQPLFEM-UHFFFAOYSA-N 50186375 CHEMBL210540::N-(5-(2-(cyclohexyloxy)-6-methylpyrimidin-4-yl)thiazol-2-yl)-5-((4-methylpiperazin-1-yl)methyl)pyrazin-2-amine Cyclin-dependent kinase 6 Homo sapiens 7.8 ChEMBL 10.1016/j.bmcl.2006.04.048 10.7270/Q2N29WK0 16682184 Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186375&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 16037675 104070424 CHEMBL210540 ZINC34804858 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50335565 O=C1c2ccccc2-[n+]2ccc3c([nH]c4ccccc34)c12 InChI=1S/C18H10N2O/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20/h1-10H/p+1 WYQIPCUPNMRAKP-UHFFFAOYSA-O 59087 CHEMBL258765::Fasca-plysi::Fascaplysin Cyclin-dependent kinase 6 Homo sapiens 3400 ChEMBL 10.1021/np050229y 10.7270/Q2FJ2GHF 16441060 McArdle, BM; Campitelli, MR; Quinn, RJ Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59087&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 73293 123080303 CHEMBL258765 ZINC01616841 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50398320 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-dependent kinase 6 Homo sapiens 39 ChEMBL 10.1016/j.bmcl.2015.05.100 10.7270/Q2736SQ1 26115571 Sánchez-Martínez, C; Gelbert, LM; Lallena, MJ; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50457095 Cn1cc(C2=C(C(=O)NC2=O)c2coc3cc(CO)ccc23)c2cc(F)c(Cl)cc12 InChI=1S/C22H14ClFN2O4/c1-26-7-13(12-5-16(24)15(23)6-17(12)26)19-20(22(29)25-21(19)28)14-9-30-18-4-10(8-27)2-3-11(14)18/h2-7,9,27H,8H2,1H3,(H,25,28,29) NZVVXITYPLCRRD-UHFFFAOYSA-N 50267523 3-(6-Chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-hydroxymethylbenzofuran-3-yl)pyrrole-2,5-dione::CHEMBL522590 Cyclin-dependent kinase 6 Homo sapiens 11600 ChEMBL 10.1021/jm801317h 10.7270/Q24M94FZ 19338355 Gaisina, IN; Gallier, F; Ougolkov, AV; Kim, KH; Kurome, T; Guo, S; Holzle, D; Luchini, DN; Blond, SY; Billadeau, DD; Kozikowski, AP University of Illinois at Chicago http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267523&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44582684 104114333 CHEMBL522590 ZINC40423538 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50457103 COc1cccc2c(coc12)C1=C(C(=O)NC1=O)c1cn(C)c2cc(Cl)c(F)cc12 InChI=1S/C22H14ClFN2O4/c1-26-8-12(11-6-15(24)14(23)7-16(11)26)18-19(22(28)25-21(18)27)13-9-30-20-10(13)4-3-5-17(20)29-2/h3-9H,1-2H3,(H,25,27,28) IATKMBHPUAENLP-UHFFFAOYSA-N 50267565 3-(6-Chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(7-methoxybenzofuran-3-yl)pyrrole-2,5-dione::CHEMBL522760 Cyclin-dependent kinase 6 Homo sapiens 165000 ChEMBL 10.1021/jm801317h 10.7270/Q24M94FZ 19338355 Gaisina, IN; Gallier, F; Ougolkov, AV; Kim, KH; Kurome, T; Guo, S; Holzle, D; Luchini, DN; Blond, SY; Billadeau, DD; Kozikowski, AP University of Illinois at Chicago http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267565&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44582716 104114375 CHEMBL522760 ZINC40423854 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50457111 Cn1cc(C2=C(C(=O)NC2=O)c2coc3cc(CO)ccc23)c2cc(Br)ccc12 InChI=1S/C22H15BrN2O4/c1-25-8-15(14-7-12(23)3-5-17(14)25)19-20(22(28)24-21(19)27)16-10-29-18-6-11(9-26)2-4-13(16)18/h2-8,10,26H,9H2,1H3,(H,24,27,28) GAVPKFXPGFHFSY-UHFFFAOYSA-N 50267607 3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(6-hydroxymethylbenzofuran-3-yl)pyrrole-2,5-dione::CHEMBL489833 Cyclin-dependent kinase 6 Homo sapiens 510 ChEMBL 10.1021/jm801317h 10.7270/Q24M94FZ 19338355 Gaisina, IN; Gallier, F; Ougolkov, AV; Kim, KH; Kurome, T; Guo, S; Holzle, D; Luchini, DN; Blond, SY; Billadeau, DD; Kozikowski, AP University of Illinois at Chicago http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267607&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44582745 104114413 CHEMBL489833 ZINC40423177 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50457119 COCc1cccc2c(cn(C)c12)C1=C(C(=O)NC1=O)c1coc2ccccc12 InChI=1S/C23H18N2O4/c1-25-10-16(15-8-5-6-13(11-28-2)21(15)25)19-20(23(27)24-22(19)26)17-12-29-18-9-4-3-7-14(17)18/h3-10,12H,11H2,1-2H3,(H,24,26,27) HGBNXMUZCGQMOG-UHFFFAOYSA-N 50267760 3-Benzofuran-3-yl-4-(7-methoxymethyl-1-methyl-1H-indol-3-yl)pyrrole-2,5-dione::CHEMBL491647 Cyclin-dependent kinase 6 Homo sapiens 8330 ChEMBL 10.1021/jm801317h 10.7270/Q24M94FZ 19338355 Gaisina, IN; Gallier, F; Ougolkov, AV; Kim, KH; Kurome, T; Guo, S; Holzle, D; Luchini, DN; Blond, SY; Billadeau, DD; Kozikowski, AP University of Illinois at Chicago http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267760&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44582838 104114520 CHEMBL491647 ZINC40950160 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50606461 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 16 ChEMBL 10.1021/jm100189a 10.7270/Q29C6XPM 20925433 Vizirianakis, IS; Chatzopoulou, M; Bonovolias, ID; Nicolaou, I; Demopoulos, VJ; Tsiftsoglou, AS Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50703218 [O-][n+]1ccc2c(ccnc2c1-c1c(Cl)cccc1Cl)-c1ccc(F)cc1Cl InChI=1S/C20H10Cl3FN2O/c21-15-2-1-3-16(22)18(15)20-19-14(7-9-26(20)27)12(6-8-25-19)13-5-4-11(24)10-17(13)23/h1-10H AUZOBOALIFKXNA-UHFFFAOYSA-N 50357884 CHEMBL1916359 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/jm200975u 10.7270/Q2MW2HKR 21999461 Lumeras, W; Vidal, L; Vidal, B; Balague, C; Orellana, A; Maldonado, M; Dominguez, M; Segarra, V; Caturla, F Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50357884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50357884&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 24896769 136961908 CHEMBL1916359 ZINC73162320 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50840542 O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12 InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1 KLVYMYQTRZCMLE-CYBMUJFWSA-N 6619 3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-pyridin-2-ylurea::CHEMBL141247::N -(pyrrolidino[2,1-b]isoindolin-4-on-8-yl)-N-(pyridin-2yl)urea::Pyridin-2-yl urea::diarylurea deriv. 1 Cyclin-dependent kinase 6 Homo sapiens 71 ChEMBL 10.1016/j.bmcl.2006.07.026 10.7270/Q2K35VF0 16876403 Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6619&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1PU 1GII,1GIH 445840 8036196 CHEMBL141247 DB04186 ZINC03591058 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50840572 C[C@@H]1C[C@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O InChI=1S/C22H21N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13,25H,8-11H2,1H3,(H,23,28)/t12-,13+/m1/s1 KBLPHMRCKHFBJB-OLZOCXBDSA-N 50192071 (13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahexacyclo[15.6.2.1^{6,9}.1^{12,15}.0^{2,7}.0^{21,25}]heptacosa-1(24),2,4,6(27),7,17(25),18,20,22-nonaene-23,27-diol::CHEMBL215803 Cyclin-dependent kinase 6 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2006.07.026 10.7270/Q2K35VF0 16876403 Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192071&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1CD 2DS1 16046126 104075026 CHEMBL215803 DB06888 ZINC36770746 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50851802 Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29) AZTMYWWWILJAKW-UHFFFAOYSA-N 50224883 7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,16-dioxa-2,4,19,21-tetraaza-tricyclo[15.3.1.0*5,10*]henicosa-1(21),5,7,9,17,19-hexaene-18-crbonitrile::CHEMBL248757 Cyclin-dependent kinase 6 Homo sapiens >1549 ChEMBL 10.1016/j.bmcl.2007.09.063 10.7270/Q2X067WT 17935989 Tao, ZF; Chen, Z; Bui, MH; Kovar, P; Johnson, E; Bouska, J; Zhang, H; Rosenberg, S; Sowin, T; Lin, NH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224883&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44444843 104096404 CHEMBL248757 ZINC28963230 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50917862 CCNc1cc(N[C@@H]2CC[C@H](O)CC2)nc(Nc2ccc3n(Cc4ccccc4)ccc3c2)n1 InChI=1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23+ YVXCDLCJCIDFHE-DKXQDJALSA-N 50378824 CHEMBL1242367 Cyclin-dependent kinase 6 Homo sapiens 5600 ChEMBL 10.1208/aapsj080125 10.7270/Q2TX3GBS 16584130 Sridhar, J; Akula, N; Pattabiraman, N Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378824&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 24825971 160857907 CHEMBL1242367 ZINC01493715 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50969399 Clc1cc(c(Cl)s1)S(=O)(=O)N(C(=O)CBr)c1ccccc1 InChI=1S/C12H8BrCl2NO3S2/c13-7-11(17)16(8-4-2-1-3-5-8)21(18,19)9-6-10(14)20-12(9)15/h1-6H,7H2 XOLGJVQMYMQCNT-UHFFFAOYSA-N 50321461 2-bromo-N-(2,5-dichlorothiophen-3-ylsulfonyl)-N-phenylacetamide::CHEMBL1171238 Cyclin-dependent kinase 6 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2012.09.044 10.7270/Q26H4JJZ 23063403 Rotella, DP Montclair State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321461&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 49798556 104142990 CHEMBL1171238 ZINC53229868 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50978415 CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1 InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19) IVYWKCAOPCHVMX-UHFFFAOYSA-N 50401152 CHEMBL2205766 Cyclin-dependent kinase 6 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2012.05.090 10.7270/Q2HQ412B 22726925 Sunose, M; Bell, K; Ellard, K; Bergamini, G; Neubauer, G; Werner, T; Ramsden, N Cellzome Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50401152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50401152&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44557921 163350176 CHEMBL2205766 ZINC95562659 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51076290 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(OC)cc2)-c2ccccc2)cc1 InChI=1S/C25H22N4O3S/c1-31-20-12-8-17(9-13-20)23-22(16-29(28-23)19-6-4-3-5-7-19)24(30)27-25(33)26-18-10-14-21(32-2)15-11-18/h3-16H,1-2H3,(H2,26,27,30,33) YECDMWPRVSKSOX-UHFFFAOYSA-N 50440135 CHEMBL2426395 Cyclin-dependent kinase 6 Homo sapiens 29 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440135&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 72707853 175452452 CHEMBL2426395 ZINC96283865 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51076291 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(F)cc2)-c2ccccc2)cc1 InChI=1S/C24H19FN4O2S/c1-31-20-13-11-18(12-14-20)26-24(32)27-23(30)21-15-29(19-5-3-2-4-6-19)28-22(21)16-7-9-17(25)10-8-16/h2-15H,1H3,(H2,26,27,30,32) OQEFZDKDXVHSRX-UHFFFAOYSA-N 50440136 CHEMBL2426391 Cyclin-dependent kinase 6 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440136&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 72707790 175452453 CHEMBL2426391 ZINC96283866 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51076292 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(Cl)cc2)-c2ccccc2)cc1 InChI=1S/C24H19ClN4O2S/c1-31-20-13-11-18(12-14-20)26-24(32)27-23(30)21-15-29(19-5-3-2-4-6-19)28-22(21)16-7-9-17(25)10-8-16/h2-15H,1H3,(H2,26,27,30,32) BASWGBOBVOPWNF-UHFFFAOYSA-N 50440137 CHEMBL2426387 Cyclin-dependent kinase 6 Homo sapiens 42 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440137&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 72707728 175452454 CHEMBL2426387 ZINC96283867 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51076293 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(C)cc2)-c2ccccc2)cc1 InChI=1S/C25H22N4O2S/c1-17-8-10-18(11-9-17)23-22(16-29(28-23)20-6-4-3-5-7-20)24(30)27-25(32)26-19-12-14-21(31-2)15-13-19/h3-16H,1-2H3,(H2,26,27,30,32) XYZIPKBTOPMPRH-UHFFFAOYSA-N 50440138 CHEMBL2426383 Cyclin-dependent kinase 6 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440138&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 72707724 175452455 CHEMBL2426383 ZINC96283868 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51076294 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccccc2)-c2ccccc2)cc1 InChI=1S/C24H20N4O2S/c1-30-20-14-12-18(13-15-20)25-24(31)26-23(29)21-16-28(19-10-6-3-7-11-19)27-22(21)17-8-4-2-5-9-17/h2-16H,1H3,(H2,25,26,29,31) BEFVJTSMLGHNEY-UHFFFAOYSA-N 50440139 CHEMBL2426399 Cyclin-dependent kinase 6 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440139&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 72707651 175452456 CHEMBL2426399 ZINC96283869 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50528210 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 21 ChEMBL 10.1016/j.ejmech.2016.07.020 10.7270/Q27P91CF 27448913 Wang, P; Huang, J; Wang, K; Gu, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50528212 CC(=O)OCOC(=O)N1CCN(CC1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1 InChI=1S/C28H33N7O6/c1-17-22-15-30-27(32-25(22)35(20-6-4-5-7-20)26(38)24(17)18(2)36)31-23-9-8-21(14-29-23)33-10-12-34(13-11-33)28(39)41-16-40-19(3)37/h8-9,14-15,20H,4-7,10-13,16H2,1-3H3,(H,29,30,31,32) AJTMZFRCOLMNQV-UHFFFAOYSA-N 50202482 CHEMBL3972685 Cyclin-dependent kinase 6 Homo sapiens 28 ChEMBL 10.1016/j.ejmech.2016.07.020 10.7270/Q27P91CF 27448913 Wang, P; Huang, J; Wang, K; Gu, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202482&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 134153020 375979687 CHEMBL3972685 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50528213 CCN1CCN(CC1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1 InChI=1S/C26H33N7O2/c1-4-31-11-13-32(14-12-31)20-9-10-22(27-15-20)29-26-28-16-21-17(2)23(18(3)34)25(35)33(24(21)30-26)19-7-5-6-8-19/h9-10,15-16,19H,4-8,11-14H2,1-3H3,(H,27,28,29,30) LICNBVSSOUPXNB-UHFFFAOYSA-N 50202483 CHEMBL3954429 Cyclin-dependent kinase 6 Homo sapiens 34 ChEMBL 10.1016/j.ejmech.2016.07.020 10.7270/Q27P91CF 27448913 Wang, P; Huang, J; Wang, K; Gu, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202483&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 134144635 375979688 CHEMBL3954429 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50528214 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)CNCCN)nc2n(C2CCCC2)c1=O InChI=1S/C28H37N9O3/c1-18-22-16-32-28(34-26(22)37(20-5-3-4-6-20)27(40)25(18)19(2)38)33-23-8-7-21(15-31-23)35-11-13-36(14-12-35)24(39)17-30-10-9-29/h7-8,15-16,20,30H,3-6,9-14,17,29H2,1-2H3,(H,31,32,33,34) JFIULCBZFIWZRF-UHFFFAOYSA-N 50202484 CHEMBL3986282 Cyclin-dependent kinase 6 Homo sapiens 23 ChEMBL 10.1016/j.ejmech.2016.07.020 10.7270/Q27P91CF 27448913 Wang, P; Huang, J; Wang, K; Gu, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202484&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 134156416 375979689 CHEMBL3986282 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50528217 COCCCNCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1 InChI=1S/C30H40N8O4/c1-20-24-18-33-30(35-28(24)38(22-7-4-5-8-22)29(41)27(20)21(2)39)34-25-10-9-23(17-32-25)36-12-14-37(15-13-36)26(40)19-31-11-6-16-42-3/h9-10,17-18,22,31H,4-8,11-16,19H2,1-3H3,(H,32,33,34,35) CVPUILJMTJRHGF-UHFFFAOYSA-N 50202485 CHEMBL3905696 Cyclin-dependent kinase 6 Homo sapiens 18 ChEMBL 10.1016/j.ejmech.2016.07.020 10.7270/Q27P91CF 27448913 Wang, P; Huang, J; Wang, K; Gu, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202485&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 134135943 375979690 CHEMBL3905696 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50747153 C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1 BHKVSOQUPYXVRZ-AWEZNQCLSA-N 50238867 CHEMBL4083249 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.7b00665 10.7270/Q2ZW1P55 28692292 Sun, QZ; Sun, QZ; Lin, GF; Lin, GF; Li, LL; Li, LL; Jin, XT; Jin, XT; Huang, LY; Huang, LY; Zhang, G; Zhang, G; Yang, W; Yang, W; Chen, K; Chen, K; Xiang, R; Xiang, R; Chen, C; Chen, C; Wei, YQ; Wei, YQ; Lu, GW; Lu, GW; Yang, SY; Yang, SY Sichuan University and Collaborative Innovation Center for Biotherapy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238867&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search SQZ 5X8I 44449865 85716661 CHEMBL4083249 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50747667 Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(O)c(O)c1 InChI=1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6- RGNXWPVNPFAADO-NSIKDUERSA-N 50580 (2Z)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-coumaran-3-one::(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one::(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-3-benzofuranone::(2Z)-2-[[3,4-bis(oxidanyl)phenyl]methylidene]-6-oxidanyl-1-benzofuran-3-one::MLS000863576::SMR000440743::SULFURETIN::cid_5281295 Cyclin-dependent kinase 6 Homo sapiens 2440 ChEMBL 10.1016/j.ejmech.2017.02.048 10.7270/Q2XW4N3P 28249207 Wang, S; Xu, L; Lu, YT; Liu, YF; Han, B; Liu, T; Tang, J; Li, J; Wu, J; Li, JY; Yu, LF; Yang, F East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50580&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 5281295 252630839 C08730 ZINC13123250 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50756478 Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1-c1cc(Cl)ccc1O InChI=1S/C27H23ClN4O2/c1-16-21-11-18(7-9-24(21)32-31-16)22-13-20(30-25(15-33)17-5-3-2-4-6-17)14-29-27(22)23-12-19(28)8-10-26(23)34/h2-14,25,30,33-34H,15H2,1H3,(H,31,32)/t25-/m0/s1 GCDSDVNITVBCDW-VWLOTQADSA-N 50240781 CHEMBL4105329 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.7b00076 10.7270/Q2K939NC 28714692 Zhu, W; Chen, H; Wang, Y; Wang, J; Peng, X; Chen, X; Gao, Y; Li, C; He, Y; Ai, J; Geng, M; Zheng, M; Liu, H University of Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240781&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44346801 85491992 CHEMBL4105329 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50756479 OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(c1)-c1ccc2cnccc2c1)c1ccccc1 InChI=1S/C28H22ClN3O2/c29-22-8-9-27(34)25(13-22)28-24(20-6-7-21-15-30-11-10-19(21)12-20)14-23(16-31-28)32-26(17-33)18-4-2-1-3-5-18/h1-16,26,32-34H,17H2/t26-/m0/s1 UMBIRSZUCJNBHB-SANMLTNESA-N 50240779 CHEMBL4067871 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.7b00076 10.7270/Q2K939NC 28714692 Zhu, W; Chen, H; Wang, Y; Wang, J; Peng, X; Chen, X; Gao, Y; Li, C; He, Y; Ai, J; Geng, M; Zheng, M; Liu, H University of Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240779&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 78016 85489484 CHEMBL4067871 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50756480 Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1-c1ccc(F)cc1O InChI=1S/C27H23FN4O2/c1-16-22-11-18(7-10-24(22)32-31-16)23-13-20(30-25(15-33)17-5-3-2-4-6-17)14-29-27(23)21-9-8-19(28)12-26(21)34/h2-14,25,30,33-34H,15H2,1H3,(H,31,32)/t25-/m0/s1 ROHJEIACUNTGFP-VWLOTQADSA-N 50240782 CHEMBL4075917 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.7b00076 10.7270/Q2K939NC 28714692 Zhu, W; Chen, H; Wang, Y; Wang, J; Peng, X; Chen, X; Gao, Y; Li, C; He, Y; Ai, J; Geng, M; Zheng, M; Liu, H University of Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240782&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44346817 85492028 CHEMBL4075917 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50756883 Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1-c1cc(F)ccc1O InChI=1S/C27H23FN4O2/c1-16-21-11-18(7-9-24(21)32-31-16)22-13-20(30-25(15-33)17-5-3-2-4-6-17)14-29-27(22)23-12-19(28)8-10-26(23)34/h2-14,25,30,33-34H,15H2,1H3,(H,31,32)/t25-/m0/s1 QXIOZIFTPMAING-VWLOTQADSA-N 50240780 CHEMBL4062877 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.7b00076 10.7270/Q2K939NC 28714692 Zhu, W; Chen, H; Wang, Y; Wang, J; Peng, X; Chen, X; Gao, Y; Li, C; He, Y; Ai, J; Geng, M; Zheng, M; Liu, H University of Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240780&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 8468 8145217 CHEMBL4062877 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113868 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C28H33FN8/c1-4-35-11-13-36(14-12-35)18-19-5-8-24(30-16-19)33-27-31-17-21(29)26(34-27)20-6-7-22-23(15-20)37-25(32-22)9-10-28(37,2)3/h5-8,15-17H,4,9-14,18H2,1-3H3,(H,30,31,33,34) JLIDFAZKTWWWCN-UHFFFAOYSA-N 50455051 CHEMBL4210028::US10696678, Example 24 Cyclin-dependent kinase 6 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455051&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102643 433923193 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113869 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)n5c4c3)nc2C)CC1 InChI=1S/C28H32F2N8/c1-4-36-9-11-37(12-10-36)16-19-6-7-24(32-18(19)3)33-28-31-15-22(30)26(35-28)20-13-21(29)27-23(14-20)38-17(2)5-8-25(38)34-27/h6-7,13-15,17H,4-5,8-12,16H2,1-3H3,(H,31,32,33,35) QQWJGOWPTXJPPN-UHFFFAOYSA-N 50455052 CHEMBL4215126::US10696678, Example 64 Cyclin-dependent kinase 6 Homo sapiens 178 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455052&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102595 433923194 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113896 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCCn5c4c3)nc2)CC1 InChI=1S/C27H30F2N8/c1-2-35-9-11-36(12-10-35)17-18-6-7-23(30-15-18)32-27-31-16-21(29)25(34-27)19-13-20(28)26-22(14-19)37-8-4-3-5-24(37)33-26/h6-7,13-16H,2-5,8-12,17H2,1H3,(H,30,31,32,34) UBYXZTIDJPASEM-UHFFFAOYSA-N 50455058 CHEMBL4208366::US10696678, Example 14 Cyclin-dependent kinase 6 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455058&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102640 433923200 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113897 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCCCn5c4c3)nc2)CC1 InChI=1S/C28H32F2N8/c1-2-36-10-12-37(13-11-36)18-19-7-8-24(31-16-19)33-28-32-17-22(30)26(35-28)20-14-21(29)27-23(15-20)38-9-5-3-4-6-25(38)34-27/h7-8,14-17H,2-6,9-13,18H2,1H3,(H,31,32,33,35) FLXBKICISVDLQT-UHFFFAOYSA-N 50455065 CHEMBL4204961::US10696678, Example 16 Cyclin-dependent kinase 6 Homo sapiens 248 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455065&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102610 433923207 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113898 CCN1CCN(Cc2ccc(Nc3nccc(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C28H33FN8/c1-4-35-11-13-36(14-12-35)18-19-5-6-24(31-17-19)33-27-30-10-8-22(32-27)20-15-21(29)26-23(16-20)37-25(34-26)7-9-28(37,2)3/h5-6,8,10,15-17H,4,7,9,11-14,18H2,1-3H3,(H,30,31,32,33) YPNMKTIHYIVLEE-UHFFFAOYSA-N 50455068 CHEMBL4205645::US10696678, Example 22 Cyclin-dependent kinase 6 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455068&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102611 433923210 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113899 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F InChI=1S/C26H28F2N8/c1-26(2)6-5-22-33-24-18(27)11-17(12-20(24)36(22)26)23-19(28)14-31-25(34-23)32-21-4-3-16(13-30-21)15-35-9-7-29-8-10-35/h3-4,11-14,29H,5-10,15H2,1-2H3,(H,30,31,32,34) DHPLYCJQWJHXFH-UHFFFAOYSA-N 448932 5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine::BDBM50455056::US10696678, Example 27 Cyclin-dependent kinase 6 Homo sapiens 3.7 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448932&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122657629 440825015 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113900 Cc1nc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)ccc1CN1CCNCC1 InChI=1S/C27H30F2N8/c1-16-17(15-36-10-8-30-9-11-36)4-5-22(32-16)33-26-31-14-20(29)24(35-26)18-12-19(28)25-21(13-18)37-23(34-25)6-7-27(37,2)3/h4-5,12-14,30H,6-11,15H2,1-3H3,(H,31,32,33,35) XBOIHCUWWMWMIZ-UHFFFAOYSA-N 448934 5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(6-m ethyl-5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine::BDBM50455055::US10696678, Example 29 Cyclin-dependent kinase 6 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448934&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102646 440825017 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113901 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2C)CC1 InChI=1S/C29H34F2N8/c1-5-37-10-12-38(13-11-37)17-19-6-7-24(33-18(19)2)34-28-32-16-22(31)26(36-28)20-14-21(30)27-23(15-20)39-25(35-27)8-9-29(39,3)4/h6-7,14-16H,5,8-13,17H2,1-4H3,(H,32,33,34,36) DHQOXLRGBCLMFX-UHFFFAOYSA-N 50455064 CHEMBL4211479::US10696678, Example 37 Cyclin-dependent kinase 6 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455064&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102568 433923206 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113902 CN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2C)CC1 InChI=1S/C28H32F2N8/c1-17-18(16-37-11-9-36(4)10-12-37)5-6-23(32-17)33-27-31-15-21(30)25(35-27)19-13-20(29)26-22(14-19)38-24(34-26)7-8-28(38,2)3/h5-6,13-15H,7-12,16H2,1-4H3,(H,31,32,33,35) OGSBFBXJSCWWMC-UHFFFAOYSA-N 50455073 CHEMBL4216447::US10696678, Example 38 Cyclin-dependent kinase 6 Homo sapiens 271 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455073&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102576 433923211 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113903 CCC1Cc2nc3c(F)cc(cc3n2C1)-c1nc(Nc2ccc(CN3CCN(CC)CC3)cn2)ncc1F InChI=1S/C28H32F2N8/c1-3-18-11-25-34-27-21(29)12-20(13-23(27)38(25)17-18)26-22(30)15-32-28(35-26)33-24-6-5-19(14-31-24)16-37-9-7-36(4-2)8-10-37/h5-6,12-15,18H,3-4,7-11,16-17H2,1-2H3,(H,31,32,33,35) UGRAFLUUHGUBAR-UHFFFAOYSA-N 50455063 CHEMBL4213109::US10696678, Example 51 Cyclin-dependent kinase 6 Homo sapiens 339 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455063&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102582 433923205 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113904 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CC(C)(C)Cn5c4c3)nc2)CC1 InChI=1S/C28H32F2N8/c1-4-36-7-9-37(10-8-36)16-18-5-6-23(31-14-18)33-27-32-15-21(30)25(35-27)19-11-20(29)26-22(12-19)38-17-28(2,3)13-24(38)34-26/h5-6,11-12,14-15H,4,7-10,13,16-17H2,1-3H3,(H,31,32,33,35) WURCEOZSLIZNTF-UHFFFAOYSA-N 50455062 CHEMBL4207804::US10696678, Example 56 Cyclin-dependent kinase 6 Homo sapiens 36 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455062&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102571 433923204 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113905 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)n5c4c3)nc2)CC1 InChI=1S/C27H30F2N8/c1-3-35-8-10-36(11-9-35)16-18-5-6-23(30-14-18)32-27-31-15-21(29)25(34-27)19-12-20(28)26-22(13-19)37-17(2)4-7-24(37)33-26/h5-6,12-15,17H,3-4,7-11,16H2,1-2H3,(H,30,31,32,34) YCANTYAOGZQCIG-UHFFFAOYSA-N 50455066 CHEMBL4212542::US10696678, Example 60 Cyclin-dependent kinase 6 Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455066&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102594 433923208 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113906 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)n5c4c3)nc2)CC1 InChI=1S/C28H32F2N8/c1-17(2)37-10-8-36(9-11-37)16-19-5-6-24(31-14-19)33-28-32-15-22(30)26(35-28)20-12-21(29)27-23(13-20)38-18(3)4-7-25(38)34-27/h5-6,12-15,17-18H,4,7-11,16H2,1-3H3,(H,31,32,33,35) JEUQWNQSQIEFOJ-UHFFFAOYSA-N 50455061 CHEMBL4211828::US10696678, Example 65 Cyclin-dependent kinase 6 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455061&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102589 433923203 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113907 CCC1CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCN(C)CC3)cn2)ncc1F InChI=1S/C27H30F2N8/c1-3-19-5-7-24-33-26-20(28)12-18(13-22(26)37(19)24)25-21(29)15-31-27(34-25)32-23-6-4-17(14-30-23)16-36-10-8-35(2)9-11-36/h4,6,12-15,19H,3,5,7-11,16H2,1-2H3,(H,30,31,32,34) YASYFVUJCWYQTN-UHFFFAOYSA-N 50455074 CHEMBL4217694::US10696678, Example 67 Cyclin-dependent kinase 6 Homo sapiens 2.4 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455074&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102600 433923212 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113908 CCN1CCN(Cc2ccc(Nc3nccc(n3)-c3cc(F)c4nc5CCC(C)n5c4c3)nc2)CC1 InChI=1S/C27H31FN8/c1-3-34-10-12-35(13-11-34)17-19-5-6-24(30-16-19)32-27-29-9-8-22(31-27)20-14-21(28)26-23(15-20)36-18(2)4-7-25(36)33-26/h5-6,8-9,14-16,18H,3-4,7,10-13,17H2,1-2H3,(H,29,30,31,32) AJXAXQOBZWUUQX-UHFFFAOYSA-N 50455067 CHEMBL4207966::US10696678, Example 73 Cyclin-dependent kinase 6 Homo sapiens 752 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455067&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102608 433923209 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113914 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 7.8 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113918 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCn5c4c3)nc2)CC1 InChI=1S/C26H28F2N8/c1-2-34-8-10-35(11-9-34)16-17-5-6-22(29-14-17)31-26-30-15-20(28)24(33-26)18-12-19(27)25-21(13-18)36-7-3-4-23(36)32-25/h5-6,12-15H,2-4,7-11,16H2,1H3,(H,29,30,31,33) MGENEBPUTRSHKN-UHFFFAOYSA-N 50455059 CHEMBL4214566::US10696678, Example 12 Cyclin-dependent kinase 6 Homo sapiens 244 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455059&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122657632 433923201 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113919 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C28H32F2N8/c1-4-36-9-11-37(12-10-36)17-18-5-6-23(31-15-18)33-27-32-16-21(30)25(35-27)19-13-20(29)26-22(14-19)38-24(34-26)7-8-28(38,2)3/h5-6,13-16H,4,7-12,17H2,1-3H3,(H,31,32,33,35) LCDCVRYMEWMBEV-UHFFFAOYSA-N 50455050 CHEMBL4208172::US10696678, Example 18::US11351170, Example 1 Cyclin-dependent kinase 6 Homo sapiens 0.900000 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455050&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122657565 433923192 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113920 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCN(CC3)C3CC3)cn2)ncc1F InChI=1S/C29H32F2N8/c1-29(2)8-7-25-35-27-21(30)13-19(14-23(27)39(25)29)26-22(31)16-33-28(36-26)34-24-6-3-18(15-32-24)17-37-9-11-38(12-10-37)20-4-5-20/h3,6,13-16,20H,4-5,7-12,17H2,1-2H3,(H,32,33,34,36) FOHJPPOWZXGQDX-UHFFFAOYSA-N 50455054 CHEMBL4207451::US10696678, Example 48 Cyclin-dependent kinase 6 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455054&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102577 433923196 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113921 CCC1CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCN(CC)CC3)cn2)ncc1F InChI=1S/C28H32F2N8/c1-3-20-6-8-25-34-27-21(29)13-19(14-23(27)38(20)25)26-22(30)16-32-28(35-26)33-24-7-5-18(15-31-24)17-37-11-9-36(4-2)10-12-37/h5,7,13-16,20H,3-4,6,8-12,17H2,1-2H3,(H,31,32,33,35) DSSKUVUQTGKPGW-UHFFFAOYSA-N 50455060 CHEMBL4213847::US10696678, Example 70 Cyclin-dependent kinase 6 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455060&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102591 433923202 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113923 CN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C27H30F2N8/c1-27(2)7-6-23-33-25-19(28)12-18(13-21(25)37(23)27)24-20(29)15-31-26(34-24)32-22-5-4-17(14-30-22)16-36-10-8-35(3)9-11-36/h4-5,12-15H,6-11,16H2,1-3H3,(H,30,31,32,34) RFEGHSBZJMLRST-UHFFFAOYSA-N 50455057 CHEMBL4215702::US10696678, Example 20 Cyclin-dependent kinase 6 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455057&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122657605 433923199 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113924 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCN(CCF)CC3)cn2)ncc1F InChI=1S/C28H31F3N8/c1-28(2)6-5-24-35-26-20(30)13-19(14-22(26)39(24)28)25-21(31)16-33-27(36-25)34-23-4-3-18(15-32-23)17-38-11-9-37(8-7-29)10-12-38/h3-4,13-16H,5-12,17H2,1-2H3,(H,32,33,34,36) PYAFOBDKPDBAIO-UHFFFAOYSA-N 50455048 CHEMBL4210707::US10696678, Example 36 Cyclin-dependent kinase 6 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455048&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102574 433923190 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113925 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CC(C)Cn5c4c3)nc2)CC1 InChI=1S/C27H30F2N8/c1-3-35-6-8-36(9-7-35)16-18-4-5-23(30-13-18)32-27-31-14-21(29)25(34-27)19-11-20(28)26-22(12-19)37-15-17(2)10-24(37)33-26/h4-5,11-14,17H,3,6-10,15-16H2,1-2H3,(H,30,31,32,34) ZZBUMHLUAAJMOY-UHFFFAOYSA-N 50455053 CHEMBL4215568::US10696678, Example 49 Cyclin-dependent kinase 6 Homo sapiens 392 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455053&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102599 433923195 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51113926 CC1CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCN(C)CC3)cn2)ncc1F InChI=1S/C26H28F2N8/c1-16-3-6-23-32-25-19(27)11-18(12-21(25)36(16)23)24-20(28)14-30-26(33-24)31-22-5-4-17(13-29-22)15-35-9-7-34(2)8-10-35/h4-5,11-14,16H,3,6-10,15H2,1-2H3,(H,29,30,31,33) DNURQZGRRIHXKJ-UHFFFAOYSA-N 50455049 CHEMBL4209318::US10696678, Example 63 Cyclin-dependent kinase 6 Homo sapiens 275 ChEMBL 10.1016/j.bmcl.2017.12.068 10.7270/Q2BC4236 29429832 Wang, Y; Liu, WJ; Yin, L; Li, H; Chen, ZH; Zhu, DX; Song, XQ; Cheng, ZZ; Song, P; Wang, Z; Li, ZG Beijing University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455049&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102598 433923191 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107226 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 1.9 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107231 CCN1CCN(Cc2ccc(Nc3cc(ncn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H33FN8/c1-5-34-8-10-35(11-9-34)16-20-6-7-25(29-15-20)33-26-14-23(30-17-31-26)21-12-22(28)27-24(13-21)36(18(2)3)19(4)32-27/h6-7,12-15,17-18H,5,8-11,16H2,1-4H3,(H,29,30,31,33) BYHCVEJLZXEHHO-UHFFFAOYSA-N 50451676 CHEMBL4214898 Cyclin-dependent kinase 6 Homo sapiens 4.4 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451676&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667385 433920821 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107232 CCN1CCN(Cc2cnc(Nc3cc(ccn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)cn2)CC1 InChI=1S/C27H33FN8/c1-5-34-8-10-35(11-9-34)17-22-15-31-26(16-30-22)33-25-14-20(6-7-29-25)21-12-23(28)27-24(13-21)36(18(2)3)19(4)32-27/h6-7,12-16,18H,5,8-11,17H2,1-4H3,(H,29,31,33) DIJLSYRZXZRGJF-UHFFFAOYSA-N 50451677 CHEMBL4204030 Cyclin-dependent kinase 6 Homo sapiens 1.6 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451677&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667296 433920822 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107233 CCN1CCN(Cc2cnc(Nc3cc(c(F)cn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)cn2)CC1 InChI=1S/C27H32F2N8/c1-5-35-6-8-36(9-7-35)16-20-13-31-26(15-30-20)34-25-12-21(23(29)14-32-25)19-10-22(28)27-24(11-19)37(17(2)3)18(4)33-27/h10-15,17H,5-9,16H2,1-4H3,(H,31,32,34) WWTFYOIDRQEIOZ-UHFFFAOYSA-N 50451678 CHEMBL4218267 Cyclin-dependent kinase 6 Homo sapiens 1.6 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451678&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667361 433920823 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107234 CCN1CCN(Cc2ccc(Nc3cc(ccn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nn2)CC1 InChI=1S/C27H33FN8/c1-5-34-10-12-35(13-11-34)17-22-6-7-25(33-32-22)31-26-16-20(8-9-29-26)21-14-23(28)27-24(15-21)36(18(2)3)19(4)30-27/h6-9,14-16,18H,5,10-13,17H2,1-4H3,(H,29,31,33) YMOIBDPPXWKGFR-UHFFFAOYSA-N 50451671 CHEMBL4205366 Cyclin-dependent kinase 6 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451671&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667312 433920816 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107235 COCCN1CCN(Cc2cnc(Nc3cc(ncn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)cn2)CC1 InChI=1S/C27H34FN9O/c1-18(2)37-19(3)33-27-22(28)11-20(12-24(27)37)23-13-25(32-17-31-23)34-26-15-29-21(14-30-26)16-36-7-5-35(6-8-36)9-10-38-4/h11-15,17-18H,5-10,16H2,1-4H3,(H,30,31,32,34) VFMJSWFJWOEIQI-UHFFFAOYSA-N 50451679 CHEMBL4214634 Cyclin-dependent kinase 6 Homo sapiens 1.6 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451679&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667350 433920824 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107236 CC(C)n1c(C)nc2c(F)cc(cc12)-c1cc(Nc2cnc(CN3CCN(CC3)C3CCCC3)cn2)ncn1 InChI=1S/C29H36FN9/c1-19(2)39-20(3)35-29-24(30)12-21(13-26(29)39)25-14-27(34-18-33-25)36-28-16-31-22(15-32-28)17-37-8-10-38(11-9-37)23-6-4-5-7-23/h12-16,18-19,23H,4-11,17H2,1-3H3,(H,32,33,34,36) LNUMMPBBRBTMNM-UHFFFAOYSA-N 50451672 CHEMBL4216534 Cyclin-dependent kinase 6 Homo sapiens 1.8 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451672&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667329 433920817 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107237 CCN1CCC(Cc2cnc(Nc3cc(ncn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)cn2)CC1 InChI=1S/C27H33FN8/c1-5-35-8-6-19(7-9-35)10-21-14-30-26(15-29-21)34-25-13-23(31-16-32-25)20-11-22(28)27-24(12-20)36(17(2)3)18(4)33-27/h11-17,19H,5-10H2,1-4H3,(H,30,31,32,34) UQNXGQYESHUBBX-UHFFFAOYSA-N 50451680 CHEMBL4207218 Cyclin-dependent kinase 6 Homo sapiens 2.9 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451680&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667252 433920825 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107257 CCN1CCN(Cc2ccc(Nc3cc(ccn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C28H34FN7/c1-5-34-10-12-35(13-11-34)18-21-6-7-26(31-17-21)33-27-16-22(8-9-30-27)23-14-24(29)28-25(15-23)36(19(2)3)20(4)32-28/h6-9,14-17,19H,5,10-13,18H2,1-4H3,(H,30,31,33) WJENEGQQOQWXTQ-UHFFFAOYSA-N 50451681 CHEMBL4208198 Cyclin-dependent kinase 6 Homo sapiens 2.9 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451681&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667293 433920826 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107258 CC(C)N1CCN(Cc2cnc(Nc3cc(ncn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)cn2)CC1 InChI=1S/C27H34FN9/c1-17(2)36-8-6-35(7-9-36)15-21-13-30-26(14-29-21)34-25-12-23(31-16-32-25)20-10-22(28)27-24(11-20)37(18(3)4)19(5)33-27/h10-14,16-18H,6-9,15H2,1-5H3,(H,30,31,32,34) HTNZLGGHWZIRJC-UHFFFAOYSA-N 50451673 CHEMBL4202432 Cyclin-dependent kinase 6 Homo sapiens 2.3 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451673&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667249 433920818 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107263 CCN1CCN(Cc2cnc(Nc3cc(ncn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)cn2)CC1 InChI=1S/C26H32FN9/c1-5-34-6-8-35(9-7-34)15-20-13-29-25(14-28-20)33-24-12-22(30-16-31-24)19-10-21(27)26-23(11-19)36(17(2)3)18(4)32-26/h10-14,16-17H,5-9,15H2,1-4H3,(H,29,30,31,33) JINXSJRUNKRAKJ-UHFFFAOYSA-N 50451685 CHEMBL4208504 Cyclin-dependent kinase 6 Homo sapiens 2.7 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451685&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667319 433920830 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107264 CC(C)n1c(C)nc2c(F)cc(cc12)-c1cc(Nc2cnc(CN3CCN(CC(F)(F)F)CC3)cn2)ncn1 InChI=1S/C26H29F4N9/c1-16(2)39-17(3)35-25-20(27)8-18(9-22(25)39)21-10-23(34-15-33-21)36-24-12-31-19(11-32-24)13-37-4-6-38(7-5-37)14-26(28,29)30/h8-12,15-16H,4-7,13-14H2,1-3H3,(H,32,33,34,36) USBNWJQZRGQXPN-UHFFFAOYSA-N 50451687 CHEMBL4214123 Cyclin-dependent kinase 6 Homo sapiens 5.8 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451687&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667328 433920832 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107265 CCN1CCC(CC1)Oc1cnc(Nc2cc(ncn2)-c2cc(F)c3nc(C)n(C(C)C)c3c2)cn1 InChI=1S/C26H31FN8O/c1-5-34-8-6-19(7-9-34)36-25-14-28-24(13-29-25)33-23-12-21(30-15-31-23)18-10-20(27)26-22(11-18)35(16(2)3)17(4)32-26/h10-16,19H,5-9H2,1-4H3,(H,28,30,31,33) ICBZKFXPIBGECC-UHFFFAOYSA-N 50451674 CHEMBL4208875 Cyclin-dependent kinase 6 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451674&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667387 433920819 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51107272 CC(C)n1c(C)nc2c(F)cc(cc12)-c1cc(Nc2cnc(CN3CCN(CC4CC4)CC3)cn2)ncn1 InChI=1S/C28H34FN9/c1-18(2)38-19(3)34-28-23(29)10-21(11-25(28)38)24-12-26(33-17-32-24)35-27-14-30-22(13-31-27)16-37-8-6-36(7-9-37)15-20-4-5-20/h10-14,17-18,20H,4-9,15-16H2,1-3H3,(H,31,32,33,35) YUTSNVSLGLNUDW-UHFFFAOYSA-N 50451688 CHEMBL4213557 Cyclin-dependent kinase 6 Homo sapiens 2.2 ChEMBL 10.1016/j.bmcl.2017.09.050 10.7270/Q2H134K1 29074254 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Shanghai HaiHe Pharmaceutial, Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50451688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50451688&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122667359 433920833 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51101930 CC(C)c1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)nc(C)nc2s1 InChI=1S/C26H32N8OS/c1-16(2)22-13-20-24(28-17(3)29-26(20)36-22)31-21-14-27-32-23(21)25(35)30-19-7-5-18(6-8-19)15-34-11-9-33(4)10-12-34/h5-8,13-14,16H,9-12,15H2,1-4H3,(H,27,32)(H,30,35)(H,28,29,31) AJLZQJOCQFFRQL-UHFFFAOYSA-N 50449544 CHEMBL4160544 Cyclin-dependent kinase 6 Homo sapiens 19 ChEMBL 10.1016/j.ejmech.2018.06.010 10.7270/Q2668GSP 29894944 Zhi, Y; Li, B; Yao, C; Li, H; Chen, P; Bao, J; Qin, T; Wang, Y; Lu, T; Lu, S China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449544&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145956666 433919139 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51101972 CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4sccc34)cc2)CC1 InChI=1S/C22H24N8OS/c1-29-7-9-30(10-8-29)13-15-2-4-16(5-3-15)26-21(31)19-18(12-25-28-19)27-20-17-6-11-32-22(17)24-14-23-20/h2-6,11-12,14H,7-10,13H2,1H3,(H,25,28)(H,26,31)(H,23,24,27) UDVJBRYBBSVDDS-UHFFFAOYSA-N 50270298 CHEMBL4075720 Cyclin-dependent kinase 6 Homo sapiens 3.3 ChEMBL 10.1016/j.ejmech.2018.06.010 10.7270/Q2668GSP 29894944 Zhi, Y; Li, B; Yao, C; Li, H; Chen, P; Bao, J; Qin, T; Wang, Y; Lu, T; Lu, S China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270298&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 72194525 404961848 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51101973 CC(C)c1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCOCC4)cc3)nc(C)nc2s1 InChI=1S/C25H29N7O2S/c1-15(2)21-12-19-23(27-16(3)28-25(19)35-21)30-20-13-26-31-22(20)24(33)29-18-6-4-17(5-7-18)14-32-8-10-34-11-9-32/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,26,31)(H,29,33)(H,27,28,30) QYUAZFYQXCJXEM-UHFFFAOYSA-N 50449551 CHEMBL4171138 Cyclin-dependent kinase 6 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2018.06.010 10.7270/Q2668GSP 29894944 Zhi, Y; Li, B; Yao, C; Li, H; Chen, P; Bao, J; Qin, T; Wang, Y; Lu, T; Lu, S China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449551&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145950262 433919146 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51101974 Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(cc2)N2CCNCC2)c2ccsc2n1 InChI=1S/C21H22N8OS/c1-13-24-19(16-6-11-31-21(16)25-13)27-17-12-23-28-18(17)20(30)26-14-2-4-15(5-3-14)29-9-7-22-8-10-29/h2-6,11-12,22H,7-10H2,1H3,(H,23,28)(H,26,30)(H,24,25,27) FHYSIHGDJOWCFJ-UHFFFAOYSA-N 50449553 CHEMBL4164331 Cyclin-dependent kinase 6 Homo sapiens 84 ChEMBL 10.1016/j.ejmech.2018.06.010 10.7270/Q2668GSP 29894944 Zhi, Y; Li, B; Yao, C; Li, H; Chen, P; Bao, J; Qin, T; Wang, Y; Lu, T; Lu, S China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449553&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145957807 433919148 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51142789 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2017.08.071 10.7270/Q2S1856W 28911822 Kalra, S; Joshi, G; Munshi, A; Kumar, R Central University of Punjab http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51142790 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2017.08.071 10.7270/Q2S1856W 28911822 Kalra, S; Joshi, G; Munshi, A; Kumar, R Central University of Punjab http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51142800 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-dependent kinase 6 Homo sapiens 6.0 ChEMBL 10.1016/j.ejmech.2017.08.071 10.7270/Q2S1856W 28911822 Kalra, S; Joshi, G; Munshi, A; Kumar, R Central University of Punjab http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51139779 CSc1ncc-2c(CCc3cnc(Nc4ccc(cc4)C(=O)N(C)CCN(C)C)nc-23)n1 InChI=1S/C23H27N7OS/c1-29(2)11-12-30(3)21(31)15-5-8-17(9-6-15)26-22-24-13-16-7-10-19-18(20(16)28-22)14-25-23(27-19)32-4/h5-6,8-9,13-14H,7,10-12H2,1-4H3,(H,24,26,28) HQYBJDBTJVHYKB-UHFFFAOYSA-N 50467169 CHEMBL4294760 Cyclin-dependent kinase 6 Homo sapiens >5000 ChEMBL 10.1016/j.bmcl.2018.08.035 10.7270/Q2NP274V 30197029 Hu, X; Zhao, H; Wang, Y; Liu, Z; Feng, B; Tang, C Jiangnan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467169&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145994117 433934434 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841757 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nnc(C(C)C)n4c3)nc2)CC1 InChI=1S/C25H30FN9/c1-4-33-9-11-34(12-10-33)15-18-5-7-21(27-13-18)29-25-28-14-20(26)23(30-25)19-6-8-22-31-32-24(17(2)3)35(22)16-19/h5-8,13-14,16-17H,4,9-12,15H2,1-3H3,(H,27,28,29,30) GASXGKPHRLRSAK-UHFFFAOYSA-N 419858 US10464927, Compound I-6 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419858&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497395 433967338 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841759 CC(C)c1nnc2ccc(cn12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C22H24FN9/c1-14(2)21-30-29-19-6-3-15(13-32(19)21)20-17(23)12-26-22(28-20)27-18-5-4-16(11-25-18)31-9-7-24-8-10-31/h3-6,11-14,24H,7-10H2,1-2H3,(H,25,26,27,28) ZAHCXBQMKVCWDI-UHFFFAOYSA-N 419859 US10464927, Compound I-7 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419859&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497364 433967339 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841765 CC(C)n1c(C(=O)N(C)C)c(F)c2c(ncnc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C25H28F2N10O/c1-14(2)37-22(24(38)35(3)4)19(27)18-21(31-13-32-23(18)37)20-16(26)12-30-25(34-20)33-17-6-5-15(11-29-17)36-9-7-28-8-10-36/h5-6,11-14,28H,7-10H2,1-4H3,(H,29,30,33,34) HYPJOMHHWLRXSR-UHFFFAOYSA-N 419862 US10464927, Compound I-10 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419862&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507743 433967342 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841761 CC(C)n1c(C)nc2cnc(nc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C22H25FN10/c1-13(2)33-14(3)28-17-12-26-20(31-21(17)33)19-16(23)11-27-22(30-19)29-18-5-4-15(10-25-18)32-8-6-24-7-9-32/h4-5,10-13,24H,6-9H2,1-3H3,(H,25,27,29,30) NKQALWSANYLMQQ-UHFFFAOYSA-N 419860 US10464927, Compound I-8 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419860&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497349 433967340 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841763 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ncc4nc(C)n(C(C)C)c4n3)nc2)CC1 InChI=1S/C25H31FN10/c1-5-34-8-10-35(11-9-34)15-18-6-7-21(27-12-18)31-25-29-13-19(26)22(32-25)23-28-14-20-24(33-23)36(16(2)3)17(4)30-20/h6-7,12-14,16H,5,8-11,15H2,1-4H3,(H,27,29,31,32) ZISIZBLHDWUJIQ-UHFFFAOYSA-N 419861 US10464927, Compound I-9 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419861&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497444 433967341 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51186102 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1 InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H IQPNAANSBPBGFQ-UHFFFAOYSA-N 7459 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL151::Luteolin (27)::Luteolin (4)::acs.jmedchem.1c00409_ST.600::cid_5280445::luteolin::med.21724, Compound 3 Cyclin-dependent kinase 6 Homo sapiens >300000 ChEMBL 10.1007/s00044-009-9233-5 10.7270/Q27M0BVB n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7459&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LU2 4HKN,4QYA,6YA5,4DGN,5AUU,6M8A,4DEW,3SZ1,7D3B,7EBV,5II2,5NDF,4QXV 5280445 11108250 15864 CHEMBL151 5215 C01514 ZINC18185774 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51186114 Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H IYRMWMYZSQPJKC-UHFFFAOYSA-N 7462 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::CHEMBL150::Kaempferol (18)::Kaempferol (Kmp)::cid_5280863::kaempferol Cyclin-dependent kinase 6 Homo sapiens 22000 ChEMBL 10.1007/s00044-009-9233-5 10.7270/Q27M0BVB n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7462&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search KMP 5AV2,4DET,5AUX,6M8B,5AV3,4REL,3QWH,1H1M,7VEJ,2C1Z 5280863 11108253 28499 CHEMBL150 DB01852 C05903 ZINC03869768 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51186115 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 6 Homo sapiens 80 ChEMBL 10.1007/s00044-009-9233-5 10.7270/Q27M0BVB n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51186116 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1 InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H RTIXKCRFFJGDFG-UHFFFAOYSA-N 7461 5,7-dihydroxy-2-phenyl-4H-chromen-4-one::5,7-dihydroxy-2-phenyl-chromen-4-one::5,7-dihydroxyflavone::CHEMBL117::chrysin::cid_5281607 Cyclin-dependent kinase 6 Homo sapiens 6000 ChEMBL 10.1007/s00044-009-9233-5 10.7270/Q27M0BVB n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7461&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 57D 4DES,3EBO,7D38 5281607 11108252 75095 CHEMBL117 C10028 ZINC03872070 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51186119 Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1 InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H KZNIFHPLKGYRTM-UHFFFAOYSA-N 7458 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::Apigenin::Apigenin (2)::Apigenin (3)::Apigenin (7)::Apigenin, 13::CHEMBL28::Naringenin, 18::US10278929, Apigenin::US11337935, Compound Apigenin::acs.jmedchem.1c00409_ST.789::cid_5280443::jm5b01461, Compound 90 Cyclin-dependent kinase 6 Homo sapiens 1700 ChEMBL 10.1007/s00044-009-9233-5 10.7270/Q27M0BVB n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7458&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search AGI 4HKK,4DGM,5I2H,5AUV,4DER,7D3A,3AMY,4WO0,3CF9,5UQT 5280443 11108249 18388 CHEMBL28 DB07352 4136 C01477 ZINC03871576 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51186125 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Cyclin-dependent kinase 6 Homo sapiens 25000 ChEMBL 10.1007/s00044-009-9233-5 10.7270/Q27M0BVB n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search QUE 3BPT,2HCK,3LJ0,4LMU,5FLI,5FLJ,3CF8,4DFU,4MRA,4WNJ,2O3P,2MS6,5AUW,3BXX,6M89,3LM5,1GP6,6AWS,6QCN,6QCD,7VUM,6B1D,2N6C,1E8W,2C9Z,5XG4,5A4V,2UXH,1H1I,2JJ2,6TTA,6IJD,3NVY 5280343 11108251 16243 CHEMBL50 DB04216 5346 C00389 ZINC03869685 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51186126 Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H XHEFDIBZLJXQHF-UHFFFAOYSA-N 7457 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromone;dihydrate::CHEMBL31574::Fisetin (14)::Fisetin, 15::fisetin Cyclin-dependent kinase 6 Homo sapiens 850 ChEMBL 10.1007/s00044-009-9233-5 10.7270/Q27M0BVB n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7457&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search FSE 4RLT,3P0H,1XO2 5281614 11108248 42567 CHEMBL31574 DB07795 5182 C10041 ZINC00039111 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841745 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841747 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(ccc4c3)C(C)C)nc2)CC1 InChI=1S/C27H32FN7/c1-4-33-11-13-34(14-12-33)18-20-5-8-25(29-16-20)31-27-30-17-23(28)26(32-27)22-6-7-24-21(15-22)9-10-35(24)19(2)3/h5-10,15-17,19H,4,11-14,18H2,1-3H3,(H,29,30,31,32) SPAJQHOPUMKBHW-UHFFFAOYSA-N 419853 US10464927, Compound I-1 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419853&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497373 433967333 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841749 CC(C)n1ccc2cc(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H26FN7/c1-16(2)32-10-7-17-13-18(3-5-21(17)32)23-20(25)15-28-24(30-23)29-22-6-4-19(14-27-22)31-11-8-26-9-12-31/h3-7,10,13-16,26H,8-9,11-12H2,1-2H3,(H,27,28,29,30) OYMLXYCGAZKDHW-UHFFFAOYSA-N 419854 US10464927, Compound I-2 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419854&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497393 433967334 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841751 CC(=O)c1cn(C2CCCC2)c2ccc(cc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C28H30FN7O/c1-18(37)23-17-36(20-4-2-3-5-20)25-8-6-19(14-22(23)25)27-24(29)16-32-28(34-27)33-26-9-7-21(15-31-26)35-12-10-30-11-13-35/h6-9,14-17,20,30H,2-5,10-13H2,1H3,(H,31,32,33,34) OYFGJGNVUYJKNV-UHFFFAOYSA-N 419855 US10464927, Compound I-3 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419855&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497402 433967335 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841753 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(cc(C(C)=O)c4c3)C3CCCC3)nc2)CC1 InChI=1S/C31H36FN7O/c1-3-37-12-14-38(15-13-37)19-22-8-11-29(33-17-22)35-31-34-18-27(32)30(36-31)23-9-10-28-25(16-23)26(21(2)40)20-39(28)24-6-4-5-7-24/h8-11,16-18,20,24H,3-7,12-15,19H2,1-2H3,(H,33,34,35,36) CLRQXDPWYVWHJI-UHFFFAOYSA-N 419856 US10464927, Compound I-4 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419856&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497387 433967336 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841755 Cc1n(C)nc2cc(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C22H23FN8/c1-14-17-5-3-15(11-19(17)29-30(14)2)21-18(23)13-26-22(28-21)27-20-6-4-16(12-25-20)31-9-7-24-8-10-31/h3-6,11-13,24H,7-10H2,1-2H3,(H,25,26,27,28) KCJJPLDURBNUMT-UHFFFAOYSA-N 419857 US10464927, Compound I-5 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419857&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497400 433967337 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841767 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ncnc4n(C5CCCC5)c(C)cc34)nc2)CC1 InChI=1S/C28H34FN9/c1-3-36-10-12-37(13-11-36)17-20-8-9-24(30-15-20)34-28-31-16-23(29)26(35-28)25-22-14-19(2)38(21-6-4-5-7-21)27(22)33-18-32-25/h8-9,14-16,18,21H,3-7,10-13,17H2,1-2H3,(H,30,31,34,35) IVURZNAEJYMDOR-UHFFFAOYSA-N 419863 US10464927, Compound I-11 Cyclin-dependent kinase 6 Homo sapiens 300 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419863&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497412 433967343 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841769 Cn1nc2nc(ccc2c1C1CCCC1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C25H28FN9/c1-34-23(16-4-2-3-5-16)18-7-8-20(30-24(18)33-34)22-19(26)15-29-25(32-22)31-21-9-6-17(14-28-21)35-12-10-27-11-13-35/h6-9,14-16,27H,2-5,10-13H2,1H3,(H,28,29,31,32) VLHPLYNDSYUAKR-UHFFFAOYSA-N 419864 US10464927, Compound I-12 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419864&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497370 433967344 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841771 CC(C)n1nc(C(N)=O)c2c(F)c(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H25F2N9O/c1-13(2)35-17-5-4-15(20(26)19(17)22(33-35)23(27)36)21-16(25)12-30-24(32-21)31-18-6-3-14(11-29-18)34-9-7-28-8-10-34/h3-6,11-13,28H,7-10H2,1-2H3,(H2,27,36)(H,29,30,31,32) ITVXLEYTVJNWDJ-UHFFFAOYSA-N 419865 US10464927, Compound I-13 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419865&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507742 433967345 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841773 CN(C)C(=O)c1cc2cc(ccc2n1C1CCCC1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C29H33FN8O/c1-36(2)28(39)25-16-20-15-19(7-9-24(20)38(25)21-5-3-4-6-21)27-23(30)18-33-29(35-27)34-26-10-8-22(17-32-26)37-13-11-31-12-14-37/h7-10,15-18,21,31H,3-6,11-14H2,1-2H3,(H,32,33,34,35) CBYUJXBONNVTCO-UHFFFAOYSA-N 419866 US10464927, Compound I-14 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419866&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507751 433967346 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841775 CCC(CC)n1c(cc2cc(ccc12)-c1nc(Nc2ccc(CN3CCN(C)CC3)cn2)ncc1Cl)C(C)=O InChI=1S/C30H36ClN7O/c1-5-24(6-2)38-26-9-8-22(15-23(26)16-27(38)20(3)39)29-25(31)18-33-30(35-29)34-28-10-7-21(17-32-28)19-37-13-11-36(4)12-14-37/h7-10,15-18,24H,5-6,11-14,19H2,1-4H3,(H,32,33,34,35) FDOSHYORLAUOGZ-UHFFFAOYSA-N 419867 US10464927, Compound I-15 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419867&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497361 433967347 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841777 CC(C)N1CCN(Cc2ccc(Nc3nccc(n3)-c3ccc4n(C)c(C)c(c4c3)C(F)(F)F)nc2)CC1 InChI=1S/C28H32F3N7/c1-18(2)38-13-11-37(12-14-38)17-20-5-8-25(33-16-20)35-27-32-10-9-23(34-27)21-6-7-24-22(15-21)26(28(29,30)31)19(3)36(24)4/h5-10,15-16,18H,11-14,17H2,1-4H3,(H,32,33,34,35) ZAYBKFLWZSRLLN-UHFFFAOYSA-N 419868 US10464927, Compound I-16 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419868&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497383 433967348 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841779 CC(C)c1c(C#N)n(C2CC2)c2ccc(cc12)-c1nc(Nc2ccc(CN3CCN(CC3)C3CC3)cn2)ncc1F InChI=1S/C32H35FN8/c1-20(2)30-25-15-22(4-9-27(25)41(24-7-8-24)28(30)16-34)31-26(33)18-36-32(38-31)37-29-10-3-21(17-35-29)19-39-11-13-40(14-12-39)23-5-6-23/h3-4,9-10,15,17-18,20,23-24H,5-8,11-14,19H2,1-2H3,(H,35,36,37,38) DBYGXKNLJCLAOW-UHFFFAOYSA-N 419869 US10464927, Compound I-17 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419869&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507777 433967349 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841781 Fc1cnc(Nc2ccc(CN3CCN(CC3)C3CCCCCC3)cn2)nc1-c1ccc2n(cc(C3CC3)c2c1)C1CCC1 InChI=1S/C36H44FN7/c37-32-22-39-36(41-35(32)27-13-14-33-30(20-27)31(26-11-12-26)24-44(33)29-8-5-9-29)40-34-15-10-25(21-38-34)23-42-16-18-43(19-17-42)28-6-3-1-2-4-7-28/h10,13-15,20-22,24,26,28-29H,1-9,11-12,16-19,23H2,(H,38,39,40,41) ZMPGSRVISHYRKW-UHFFFAOYSA-N 419870 US10464927, Compound I-18 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419870&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497384 433967350 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841783 Fc1cnc(Nc2ccc(CN3CCN(CC3)C3CCCCC3)cn2)nc1-c1ccc2n(cc(C3CCC3)c2c1)C1CCCCC1 InChI=1S/C38H48FN7/c39-34-24-41-38(42-36-17-14-27(23-40-36)25-44-18-20-45(21-19-44)30-10-3-1-4-11-30)43-37(34)29-15-16-35-32(22-29)33(28-8-7-9-28)26-46(35)31-12-5-2-6-13-31/h14-17,22-24,26,28,30-31H,1-13,18-21,25H2,(H,40,41,42,43) BBPXSUYRPKRMFP-UHFFFAOYSA-N 419871 US10464927, Compound I-19 Cyclin-dependent kinase 6 Homo sapiens >500 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419871&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497366 433967351 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841785 CC(=O)c1cn(C2CCCCCC2)c2ccc(cc12)-c1nc(Nc2ccc(CN3CCN(CC3)C3CCCC3)cn2)ncc1F InChI=1S/C36H44FN7O/c1-25(45)31-24-44(29-10-4-2-3-5-11-29)33-14-13-27(20-30(31)33)35-32(37)22-39-36(41-35)40-34-15-12-26(21-38-34)23-42-16-18-43(19-17-42)28-8-6-7-9-28/h12-15,20-22,24,28-29H,2-11,16-19,23H2,1H3,(H,38,39,40,41) RXNLCPMDBZCJBC-UHFFFAOYSA-N 419872 US10464927, Compound I-20 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419872&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497443 433967352 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841787 CC(C)n1c(cc2cc(ccc12)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C2CCC2)ncc1F)C1CCCC1 InChI=1S/C33H40FN7/c1-22(2)41-29-12-10-24(18-25(29)19-30(41)23-6-3-4-7-23)32-28(34)21-36-33(38-32)37-31-13-11-27(20-35-31)40-16-14-39(15-17-40)26-8-5-9-26/h10-13,18-23,26H,3-9,14-17H2,1-2H3,(H,35,36,37,38) RQUNQBYFMRWEJY-UHFFFAOYSA-N 419873 US10464927, Compound I-21 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419873&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497386 433967353 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841789 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(C5CCCC5)c(cc4c3)C(=O)N(C)C)nc2)CC1 InChI=1S/C32H39FN8O/c1-4-39-13-15-40(16-14-39)21-22-9-12-29(34-19-22)36-32-35-20-26(33)30(37-32)23-10-11-27-24(17-23)18-28(31(42)38(2)3)41(27)25-7-5-6-8-25/h9-12,17-20,25H,4-8,13-16,21H2,1-3H3,(H,34,35,36,37) CNCVBTJIURCUID-UHFFFAOYSA-N 419874 US10464927, Compound I-22 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419874&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137540724 433967354 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841791 CC(C)n1c(cc2cc(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F)C(C)=O InChI=1S/C26H28FN7O/c1-16(2)34-22-6-4-18(12-19(22)13-23(34)17(3)35)25-21(27)15-30-26(32-25)31-24-7-5-20(14-29-24)33-10-8-28-9-11-33/h4-7,12-16,28H,8-11H2,1-3H3,(H,29,30,31,32) VFYOURKNCAQEBG-UHFFFAOYSA-N 419875 US10464927, Compound I-23 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419875&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497362 433967355 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841793 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(C(C)C)c(cc4c3)C(C)=O)nc2)CC1 InChI=1S/C29H34FN7O/c1-5-35-10-12-36(13-11-35)18-21-6-9-27(31-16-21)33-29-32-17-24(30)28(34-29)22-7-8-25-23(14-22)15-26(20(4)38)37(25)19(2)3/h6-9,14-17,19H,5,10-13,18H2,1-4H3,(H,31,32,33,34) IAYBYTVEGSHHQS-UHFFFAOYSA-N 419876 US10464927, Compound I-24 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419876&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497356 433967356 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841795 CC(C)n1c(cc2nc(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F)C(=O)N(C)C InChI=1S/C26H30FN9O/c1-16(2)36-21-7-6-19(31-20(21)13-22(36)25(37)34(3)4)24-18(27)15-30-26(33-24)32-23-8-5-17(14-29-23)35-11-9-28-10-12-35/h5-8,13-16,28H,9-12H2,1-4H3,(H,29,30,32,33) DKAPHJSCSNQZJL-UHFFFAOYSA-N 419877 US10464927, Compound I-25 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419877&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507663 433967357 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841797 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(C(C)C)c(cc4n3)C(=O)N(C)C)nc2)CC1 InChI=1S/C29H36FN9O/c1-6-37-11-13-38(14-12-37)18-20-7-10-26(31-16-20)34-29-32-17-21(30)27(35-29)22-8-9-24-23(33-22)15-25(28(40)36(4)5)39(24)19(2)3/h7-10,15-17,19H,6,11-14,18H2,1-5H3,(H,31,32,34,35) PESDDIWZFXRDOX-UHFFFAOYSA-N 419878 US10464927, Compound I-26 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419878&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507820 433967358 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841799 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(C(C)C)c(cc4c3F)C(=O)N(C)C)nc2)CC1 InChI=1S/C30H36F2N8O/c1-6-38-11-13-39(14-12-38)18-20-7-10-26(33-16-20)35-30-34-17-23(31)28(36-30)21-8-9-24-22(27(21)32)15-25(29(41)37(4)5)40(24)19(2)3/h7-10,15-17,19H,6,11-14,18H2,1-5H3,(H,33,34,35,36) KPTBLRZGGXXJBN-UHFFFAOYSA-N 419879 US10464927, Compound I-27 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419879&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507679 433967359 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841801 CC(C)n1c(cc2c(F)c(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F)C(=O)N(C)C InChI=1S/C27H30F2N8O/c1-16(2)37-21-7-6-18(24(29)19(21)13-22(37)26(38)35(3)4)25-20(28)15-32-27(34-25)33-23-8-5-17(14-31-23)36-11-9-30-10-12-36/h5-8,13-16,30H,9-12H2,1-4H3,(H,31,32,33,34) SCBGKGYVHKAFEK-UHFFFAOYSA-N 419880 US10464927, Compound I-28 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419880&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507680 433967360 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841803 CC(=O)c1n(nc2nc(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F)C1CC1 InChI=1S/C24H24FN9O/c1-14(35)22-17-5-6-19(29-23(17)32-34(22)15-2-3-15)21-18(25)13-28-24(31-21)30-20-7-4-16(12-27-20)33-10-8-26-9-11-33/h4-7,12-13,15,26H,2-3,8-11H2,1H3,(H,27,28,30,31) ZIHBSOKSKHYONQ-UHFFFAOYSA-N 419881 US10464927, Compound I-29 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419881&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497423 433967361 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841805 CC(C)c1n(C)nc2c(Cl)c(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H26ClFN8/c1-14(2)23-17-6-5-16(20(25)22(17)32-33(23)3)21-18(26)13-29-24(31-21)30-19-7-4-15(12-28-19)34-10-8-27-9-11-34/h4-7,12-14,27H,8-11H2,1-3H3,(H,28,29,30,31) UUISHNHWHXAOKX-UHFFFAOYSA-N 419882 US10464927, Compound I-30 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419882&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507745 433967362 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841807 CN(C)C(=O)c1n(C)nc2c(F)c(ccc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H25F2N9O/c1-33(2)23(36)22-16-6-5-15(19(26)21(16)32-34(22)3)20-17(25)13-29-24(31-20)30-18-7-4-14(12-28-18)35-10-8-27-9-11-35/h4-7,12-13,27H,8-11H2,1-3H3,(H,28,29,30,31) HUMWKUQZKULQBC-UHFFFAOYSA-N 419883 US10464927, Compound I-31 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419883&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507756 433967363 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841809 CC(=O)c1nc(C2CC2)n2cc(cc(F)c12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C25H24F2N8O/c1-14(36)21-23-18(26)10-16(13-35(23)24(32-21)15-2-3-15)22-19(27)12-30-25(33-22)31-20-5-4-17(11-29-20)34-8-6-28-7-9-34/h4-5,10-13,15,28H,2-3,6-9H2,1H3,(H,29,30,31,33) HCAPBCXBINJAJC-UHFFFAOYSA-N 419884 US10464927, Compound I-32 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419884&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497390 433967364 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841811 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nnc(n4c3)C(F)(F)F)nc2)CC1 InChI=1S/C23H23F4N9/c1-2-34-7-9-35(10-8-34)13-15-3-5-18(28-11-15)30-22-29-12-17(24)20(31-22)16-4-6-19-32-33-21(23(25,26)27)36(19)14-16/h3-6,11-12,14H,2,7-10,13H2,1H3,(H,28,29,30,31) DMVYBFYTSNOASY-UHFFFAOYSA-N 419885 US10464927, Compound I-33 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419885&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497454 433967365 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841813 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4ncc(C#N)n4c3)nc2)CC1 InChI=1S/C24H24FN9/c1-2-32-7-9-33(10-8-32)15-17-3-5-21(27-12-17)30-24-29-14-20(25)23(31-24)18-4-6-22-28-13-19(11-26)34(22)16-18/h3-6,12-14,16H,2,7-10,15H2,1H3,(H,27,29,30,31) OSNAHLHLNKIDPE-UHFFFAOYSA-N 419886 US10464927, Compound I-34 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419886&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497404 433967366 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841815 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nnc(C(C)=O)n4c3)nc2)CC1 InChI=1S/C24H26FN9O/c1-3-32-8-10-33(11-9-32)14-17-4-6-20(26-12-17)28-24-27-13-19(25)22(29-24)18-5-7-21-30-31-23(16(2)35)34(21)15-18/h4-7,12-13,15H,3,8-11,14H2,1-2H3,(H,26,27,28,29) ONESBFJNZYJCEA-UHFFFAOYSA-N 419887 US10464927, Compound I-35 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419887&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497410 433967367 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841817 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nnc(C5CC5)n4c3)nc2)CC1 InChI=1S/C25H28FN9/c1-2-33-9-11-34(12-10-33)15-17-3-7-21(27-13-17)29-25-28-14-20(26)23(30-25)19-6-8-22-31-32-24(18-4-5-18)35(22)16-19/h3,6-8,13-14,16,18H,2,4-5,9-12,15H2,1H3,(H,27,28,29,30) YRBQLVGJHCSRMK-UHFFFAOYSA-N 419888 US10464927, Compound I-36 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419888&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497352 433967368 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841819 CN(C)C(=O)c1nc2cnc(nc2n1C1CCCC1)-c1nc(Nc2ccc(cn2)N2CCN(C)CC2)ncc1F InChI=1S/C27H32FN11O/c1-36(2)26(40)25-32-20-16-30-23(35-24(20)39(25)17-6-4-5-7-17)22-19(28)15-31-27(34-22)33-21-9-8-18(14-29-21)38-12-10-37(3)11-13-38/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,29,31,33,34) JGJKFGRESRDOCY-UHFFFAOYSA-N 419889 US10464927, Compound I-37 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419889&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507685 433967369 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841821 CC(C)n1c(nc2cnc(nc12)-c1nc(Nc2ccc(CN3CCN(C)CC3)cn2)ncc1F)C(C)=O InChI=1S/C25H29FN10O/c1-15(2)36-23(16(3)37)30-19-13-28-22(33-24(19)36)21-18(26)12-29-25(32-21)31-20-6-5-17(11-27-20)14-35-9-7-34(4)8-10-35/h5-6,11-13,15H,7-10,14H2,1-4H3,(H,27,29,31,32) XDQCCPQLCPMYBP-UHFFFAOYSA-N 419890 US10464927, Compound I-38 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419890&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497376 433967370 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841823 CCC(CC)n1c(nc2cnc(nc12)-c1nc(Nc2ccc(CN3CCN(C)CC3)cn2)ncc1F)C(C)C InChI=1S/C28H37FN10/c1-6-20(7-2)39-26(18(3)4)33-22-16-31-25(36-27(22)39)24-21(29)15-32-28(35-24)34-23-9-8-19(14-30-23)17-38-12-10-37(5)11-13-38/h8-9,14-16,18,20H,6-7,10-13,17H2,1-5H3,(H,30,32,34,35) IQALLMZQUILZDS-UHFFFAOYSA-N 419891 US10464927, Compound I-39 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419891&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497416 433967371 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841825 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ncc4nc(C(=O)N(C)C)n(C)c4n3)nc2)CC1 InChI=1S/C25H30FN11O/c1-5-36-8-10-37(11-9-36)15-16-6-7-19(27-12-16)31-25-29-13-17(26)20(32-25)21-28-14-18-22(33-21)35(4)23(30-18)24(38)34(2)3/h6-7,12-14H,5,8-11,15H2,1-4H3,(H,27,29,31,32) JEKCNQGMTAKGNP-UHFFFAOYSA-N 419892 US10464927, Compound I-40 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419892&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507761 433967372 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841827 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ncnc4n(C5CC5)c(cc34)C(C)=O)nc2)CC1 InChI=1S/C27H30FN9O/c1-3-35-8-10-36(11-9-35)15-18-4-7-23(29-13-18)33-27-30-14-21(28)25(34-27)24-20-12-22(17(2)38)37(19-5-6-19)26(20)32-16-31-24/h4,7,12-14,16,19H,3,5-6,8-11,15H2,1-2H3,(H,29,30,33,34) KOQDVQCEGUHCRE-UHFFFAOYSA-N 419893 US10464927, Compound I-41 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419893&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497355 433967373 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841829 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ncnc4n(C)cc(C#N)c34)nc2)CC1 InChI=1S/C24H25FN10/c1-3-34-6-8-35(9-7-34)13-16-4-5-19(27-11-16)31-24-28-12-18(25)21(32-24)22-20-17(10-26)14-33(2)23(20)30-15-29-22/h4-5,11-12,14-15H,3,6-9,13H2,1-2H3,(H,27,28,31,32) DEBTWFPFWDYMII-UHFFFAOYSA-N 419894 US10464927, Compound I-42 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419894&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497382 433967374 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841831 CN(C)C(=O)c1nn(C2CCCC2)c2ccc(cc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C28H32FN9O/c1-36(2)27(39)26-21-15-18(7-9-23(21)38(35-26)19-5-3-4-6-19)25-22(29)17-32-28(34-25)33-24-10-8-20(16-31-24)37-13-11-30-12-14-37/h7-10,15-17,19,30H,3-6,11-14H2,1-2H3,(H,31,32,33,34) LRIWWTBKMUBOHH-UHFFFAOYSA-N 419895 US10464927, Compound I-43 Cyclin-dependent kinase 6 Homo sapiens <20 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419895&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137507771 433967375 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841833 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(nc(C(C)=O)c4c3)C(C)C)nc2)CC1 InChI=1S/C28H33FN8O/c1-5-35-10-12-36(13-11-35)17-20-6-9-25(30-15-20)32-28-31-16-23(29)27(33-28)21-7-8-24-22(14-21)26(19(4)38)34-37(24)18(2)3/h6-9,14-16,18H,5,10-13,17H2,1-4H3,(H,30,31,32,33) ZZLLTGVVEWYDGL-UHFFFAOYSA-N 419896 US10464927, Compound I-44 Cyclin-dependent kinase 6 Homo sapiens >500 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419896&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497408 433967376 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841835 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(nc(C)c4c3F)C3CCCC3)nc2)CC1 InChI=1S/C29H34F2N8/c1-3-37-12-14-38(15-13-37)18-20-8-11-25(32-16-20)34-29-33-17-23(30)28(35-29)22-9-10-24-26(27(22)31)19(2)36-39(24)21-6-4-5-7-21/h8-11,16-17,21H,3-7,12-15,18H2,1-2H3,(H,32,33,34,35) WCYXZWGSJXHMPW-UHFFFAOYSA-N 419897 US10464927, Compound I-45 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419897&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497394 433967377 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841837 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4n(nc(c4n3)C(F)(F)F)C3CCCC3)nc2)CC1 InChI=1S/C28H31F4N9/c1-2-39-11-13-40(14-12-39)17-18-7-10-23(33-15-18)36-27-34-16-20(29)24(37-27)21-8-9-22-25(35-21)26(28(30,31)32)38-41(22)19-5-3-4-6-19/h7-10,15-16,19H,2-6,11-14,17H2,1H3,(H,33,34,36,37) MRBRAJMKQXXCBZ-UHFFFAOYSA-N 419898 US10464927, Compound I-46 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419898&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497369 433967378 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841839 CC(C)n1c(C)nc2cnc(nc12)-c1nc(Nc2ccc(cn2)N2CCN(C)CC2)ncc1F InChI=1S/C23H27FN10/c1-14(2)34-15(3)28-18-13-26-21(31-22(18)34)20-17(24)12-27-23(30-20)29-19-6-5-16(11-25-19)33-9-7-32(4)8-10-33/h5-6,11-14H,7-10H2,1-4H3,(H,25,27,29,30) LOOPLEAINRGVLG-UHFFFAOYSA-N 419899 US10464927, Compound I-47 Cyclin-dependent kinase 6 Homo sapiens 60 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419899&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497374 433967379 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 841841 CCN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2ncc3nc(C)n(C(C)C)c3n2)nc1 InChI=1S/C24H29FN10/c1-5-33-8-10-34(11-9-33)17-6-7-20(26-12-17)30-24-28-13-18(25)21(31-24)22-27-14-19-23(32-22)35(15(2)3)16(4)29-19/h6-7,12-15H,5,8-11H2,1-4H3,(H,26,28,30,31) XNQZQWUEDLIWFN-UHFFFAOYSA-N 419900 US10464927, Compound I-48 Cyclin-dependent kinase 6 Homo sapiens 300 US Patent 10.7270/Q23B62GC aid1803955 US10464927 Zheng, Y; Jin, H; Zhou, F; Huang, M; Meng, X Shanghai Xunhe Pharmaceutical Technology Co. Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419900&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137497417 433967380 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 885584 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-dependent kinase 6 Homo sapiens 26.9 US Patent 10.7270/Q2RV0R3H aid1804280 US10570141 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 885586 CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C21H27N7O2S/c1-31(29,30)19-12-15-13-24-21(26-20(15)28(19)16-4-2-3-5-16)25-18-7-6-17(14-23-18)27-10-8-22-9-11-27/h6-7,12-14,16,22H,2-5,8-11H2,1H3,(H,23,24,25,26) YVMZPLLKFCKPIL-UHFFFAOYSA-N 435712 US10570141, Example 1 Cyclin-dependent kinase 6 Homo sapiens 5.70 US Patent 10.7270/Q2RV0R3H aid1804280 US10570141 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=435712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=435712&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137440000 438644425 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 885588 CCS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C22H29N7O2S/c1-2-32(30,31)20-13-16-14-25-22(27-21(16)29(20)17-5-3-4-6-17)26-19-8-7-18(15-24-19)28-11-9-23-10-12-28/h7-8,13-15,17,23H,2-6,9-12H2,1H3,(H,24,25,26,27) VTLCELVAADXYMP-UHFFFAOYSA-N 435713 US10570141, Example 2 Cyclin-dependent kinase 6 Homo sapiens 21.0 US Patent 10.7270/Q2RV0R3H aid1804280 US10570141 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=435713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=435713&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137439910 438644426 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 885590 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3cc(n(C4CCCC4)c3n2)S(C)(=O)=O)nc1 InChI=1S/C24H33N7O2S/c1-29(2)18-10-12-30(13-11-18)20-8-9-21(25-16-20)27-24-26-15-17-14-22(34(3,32)33)31(23(17)28-24)19-6-4-5-7-19/h8-9,14-16,18-19H,4-7,10-13H2,1-3H3,(H,25,26,27,28) AGQLFAHPXTYWNF-UHFFFAOYSA-N 435714 US10570141, Example 3 Cyclin-dependent kinase 6 Homo sapiens 18.7 US Patent 10.7270/Q2RV0R3H aid1804280 US10570141 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=435714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=435714&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137439951 438644427 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 885592 CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1 InChI=1S/C22H26N6O2S/c1-31(29,30)20-12-17-14-25-22(27-21(17)28(20)18-4-2-3-5-18)26-19-7-6-16(13-24-19)15-8-10-23-11-9-15/h6-8,12-14,18,23H,2-5,9-11H2,1H3,(H,24,25,26,27) IRSCSJFRHYGVQY-UHFFFAOYSA-N 435715 US10570141, Example 4 Cyclin-dependent kinase 6 Homo sapiens 11.1 US Patent 10.7270/Q2RV0R3H aid1804280 US10570141 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=435715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=435715&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137445686 438644428 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 885594 CS(=O)(=O)c1cc2cnc(Nc3ccc(cn3)C3CCNCC3)nc2n1C1CCCC1 InChI=1S/C22H28N6O2S/c1-31(29,30)20-12-17-14-25-22(27-21(17)28(20)18-4-2-3-5-18)26-19-7-6-16(13-24-19)15-8-10-23-11-9-15/h6-7,12-15,18,23H,2-5,8-11H2,1H3,(H,24,25,26,27) DHFGHSZKOLMKGI-UHFFFAOYSA-N 435716 US10570141, Example 5 Cyclin-dependent kinase 6 Homo sapiens 9.85 US Patent 10.7270/Q2RV0R3H aid1804280 US10570141 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=435716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=435716&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137439941 438644429 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 885596 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C3=CCNCC3)nc2n1C1CCCC1 InChI=1S/C24H29N7O/c1-30(2)23(32)20-13-18-15-27-24(29-22(18)31(20)19-5-3-4-6-19)28-21-8-7-17(14-26-21)16-9-11-25-12-10-16/h7-9,13-15,19,25H,3-6,10-12H2,1-2H3,(H,26,27,28,29) PPCNFXQXVGAXIF-UHFFFAOYSA-N 435717 US10570141, Example 6 Cyclin-dependent kinase 6 Homo sapiens 30.6 US Patent 10.7270/Q2RV0R3H aid1804280 US10570141 Wang, S; Chen, K; Liu, X; Hu, Y; Liu, B; Peng, Y; Luo, H; Han, Y; Wang, S; Liu, M; Xu, H CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=435717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=435717&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137445685 438644430 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907122 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1CCN(C)C InChI=1S/C29H36F2N8/c1-17-12-23-19(16-38(17)11-10-37(6)7)8-9-25(34-23)35-28-32-15-22(31)26(36-28)20-13-21(30)27-24(14-20)39(18(2)33-27)29(3,4)5/h8-9,13-15,17H,10-12,16H2,1-7H3,(H,32,34,35,36)/t17-/m1/s1 XKPZMRRASYJBKC-QGZVFWFLSA-N 444589 US10662186, Compound 112::US10662186, Compound 114 Cyclin-dependent kinase 6 Homo sapiens 1.70 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444589&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196716 440706831 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907125 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1CCN(C)C InChI=1S/C29H36F2N8/c1-17-12-23-19(16-38(17)11-10-37(6)7)8-9-25(34-23)35-28-32-15-22(31)26(36-28)20-13-21(30)27-24(14-20)39(18(2)33-27)29(3,4)5/h8-9,13-15,17H,10-12,16H2,1-7H3,(H,32,34,35,36)/t17-/m1/s1 XKPZMRRASYJBKC-QGZVFWFLSA-N 444589 US10662186, Compound 112::US10662186, Compound 114 Cyclin-dependent kinase 6 Homo sapiens 1.77 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444589&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196716 440706831 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907128 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)12-20(13-24(27)38(17)15-18-4-5-18)26-22(30)14-31-28(35-26)34-25-7-6-19-16-37(11-10-36(2)3)9-8-23(19)33-25/h6-7,12-14,18H,4-5,8-11,15-16H2,1-3H3,(H,31,33,34,35) IUYLNMPIDQAYSG-UHFFFAOYSA-N 444591 US10662186, Compound 126::US10988476, Compound I-126 Cyclin-dependent kinase 6 Homo sapiens 6.26 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444591&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196705 440706832 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907131 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 6 Homo sapiens 4.88 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907134 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(C[C@@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C29H34F2N8O/c1-17-34-27-21(30)11-19(12-24(27)39(17)29(2,3)4)26-22(31)14-33-28(37-26)36-25-6-5-18-15-38(9-7-23(18)35-25)16-20-13-32-8-10-40-20/h5-6,11-12,14,20,32H,7-10,13,15-16H2,1-4H3,(H,33,35,36,37)/t20-/m0/s1 LQHMJVOJVOLFTJ-FQEVSTJZSA-N 444593 US10662186, Compound 129 Cyclin-dependent kinase 6 Homo sapiens 1.13 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444593&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196707 440706833 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907137 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(C[C@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C29H34F2N8O/c1-17-34-27-21(30)11-19(12-24(27)39(17)29(2,3)4)26-22(31)14-33-28(37-26)36-25-6-5-18-15-38(9-7-23(18)35-25)16-20-13-32-8-10-40-20/h5-6,11-12,14,20,32H,7-10,13,15-16H2,1-4H3,(H,33,35,36,37)/t20-/m1/s1 LQHMJVOJVOLFTJ-HXUWFJFHSA-N 444594 US10662186, Compound 130 Cyclin-dependent kinase 6 Homo sapiens 1.48 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444594&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196712 440706834 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907140 CN1CCC[C@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m0/s1 DSMBDRWDECFDNR-NRFANRHFSA-N 444595 US10662186, Compound 131::US10988476, Compound I-131 Cyclin-dependent kinase 6 Homo sapiens 1.41 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444595&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196723 440706835 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907143 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCNC(N)=N)CCc3n2)ncc1F InChI=1S/C26H30F2N10/c1-14(2)38-15(3)33-24-18(27)10-17(11-21(24)38)23-19(28)12-32-26(36-23)35-22-5-4-16-13-37(8-6-20(16)34-22)9-7-31-25(29)30/h4-5,10-12,14H,6-9,13H2,1-3H3,(H4,29,30,31)(H,32,34,35,36) FTFHCSWIOVPGGS-UHFFFAOYSA-N 444596 US10662186, Compound 132::US10988476, Compound I-132 Cyclin-dependent kinase 6 Homo sapiens 0.770 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444596&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196690 440706836 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907146 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CCNC(N)=N)CCc3n2)ncc1F InChI=1S/C29H37F2N11/c1-17(2)42-18(3)36-27-21(30)13-20(14-24(27)42)26-22(31)15-35-29(39-26)38-25-6-5-19-16-41(9-7-23(19)37-25)12-11-40(4)10-8-34-28(32)33/h5-6,13-15,17H,7-12,16H2,1-4H3,(H4,32,33,34)(H,35,37,38,39) PQWACVUXFPZERA-UHFFFAOYSA-N 444597 US10662186, Compound 133::US10988476, Compound I-133 Cyclin-dependent kinase 6 Homo sapiens 1.82 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444597&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196717 440706837 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907149 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CC[Si](C)(C)C)CCc3n2)ncc1F InChI=1S/C31H42F2N8Si/c1-20(2)41-21(3)35-30-24(32)16-23(17-27(30)41)29-25(33)18-34-31(38-29)37-28-9-8-22-19-40(11-10-26(22)36-28)13-12-39(4)14-15-42(5,6)7/h8-9,16-18,20H,10-15,19H2,1-7H3,(H,34,36,37,38) SXVVQLGGDQUNKQ-UHFFFAOYSA-N 444598 US10662186, Compound 134::US10988476, Compound I-134 Cyclin-dependent kinase 6 Homo sapiens 1.59 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444598&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763692 440706838 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907152 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(=S)n4ccnc4)CCc3n2)ncc1F InChI=1S/C30H32F2N10S/c1-18(2)42-19(3)35-28-22(31)13-21(14-25(28)42)27-23(32)15-34-29(38-27)37-26-6-5-20-16-40(9-7-24(20)36-26)12-11-39(4)30(43)41-10-8-33-17-41/h5-6,8,10,13-15,17-18H,7,9,11-12,16H2,1-4H3,(H,34,36,37,38) QDTMPQOORBQFIG-UHFFFAOYSA-N 444599 US10662186, Compound 135::US10988476, Compound I-135 Cyclin-dependent kinase 6 Homo sapiens 111 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444599&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196728 440706839 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907155 Cc1nc2c(F)cc(cc2n1C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C21H19F2N7/c1-11-26-20-14(22)7-13(8-17(20)30(11)2)19-15(23)10-25-21(29-19)28-18-4-3-12-9-24-6-5-16(12)27-18/h3-4,7-8,10,24H,5-6,9H2,1-2H3,(H,25,27,28,29) MSIYPAKNNNBUFM-UHFFFAOYSA-N 444600 US10662186, Compound 136::US10662186, Compound 139::US10988476, Compound I-136 Cyclin-dependent kinase 6 Homo sapiens 84.2 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444600&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196725 440706840 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907158 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCC(N)NO)CCc3n2)ncc1F InChI=1S/C26H31F2N9O/c1-14(2)37-15(3)31-25-18(27)10-17(11-21(25)37)24-19(28)12-30-26(34-24)33-23-5-4-16-13-36(8-6-20(16)32-23)9-7-22(29)35-38/h4-5,10-12,14,22,35,38H,6-9,13,29H2,1-3H3,(H,30,32,33,34) XXBMNYHUMYIUIC-UHFFFAOYSA-N 444601 US10662186, Compound 137 Cyclin-dependent kinase 6 Homo sapiens 4.78 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444601&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802643 440706841 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907161 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C)c4c3)ccc2C1 InChI=1S/C25H28F2N8/c1-15-29-24-18(26)11-17(12-21(24)34(15)4)23-19(27)13-28-25(32-23)31-22-6-5-16-14-35(10-9-33(2)3)8-7-20(16)30-22/h5-6,11-13H,7-10,14H2,1-4H3,(H,28,30,31,32) DCHQNZAIUFIFEB-UHFFFAOYSA-N 444602 US10662186, Compound 138::US10988476, Compound I-138 Cyclin-dependent kinase 6 Homo sapiens 33.0 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444602&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196729 440706842 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907164 Cc1nc2c(F)cc(cc2n1C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C21H19F2N7/c1-11-26-20-14(22)7-13(8-17(20)30(11)2)19-15(23)10-25-21(29-19)28-18-4-3-12-9-24-6-5-16(12)27-18/h3-4,7-8,10,24H,5-6,9H2,1-2H3,(H,25,27,28,29) MSIYPAKNNNBUFM-UHFFFAOYSA-N 444600 US10662186, Compound 136::US10662186, Compound 139::US10988476, Compound I-136 Cyclin-dependent kinase 6 Homo sapiens 29.3 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444600&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196725 440706840 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907167 CCn1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C26H30F2N8/c1-5-36-16(2)30-25-19(27)12-18(13-22(25)36)24-20(28)14-29-26(33-24)32-23-7-6-17-15-35(11-10-34(3)4)9-8-21(17)31-23/h6-7,12-14H,5,8-11,15H2,1-4H3,(H,29,31,32,33) JNZTWAOEOYBNNP-UHFFFAOYSA-N 444604 US10662186, Compound 140::US10988476, Compound I-140 Cyclin-dependent kinase 6 Homo sapiens 5.67 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444604&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196730 440706843 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907170 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-15-31-25-19(27)11-17(12-22(25)36(15)18-4-5-18)24-20(28)13-30-26(34-24)33-23-6-3-16-14-35(10-8-29-2)9-7-21(16)32-23/h3,6,11-13,18,29H,4-5,7-10,14H2,1-2H3,(H,30,32,33,34) JRGMQQCQWFMKLA-UHFFFAOYSA-N 444605 US10662186, Compound 142::US10988476, Compound I-142 Cyclin-dependent kinase 6 Homo sapiens 3.25 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444605&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196895 440706844 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907173 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCOCC4)CCc3n2)ncc1F InChI=1S/C30H36F2N8O/c1-19-34-28-22(31)15-21(16-25(28)40(19)30(2,3)4)27-23(32)17-33-29(37-27)36-26-6-5-20-18-39(8-7-24(20)35-26)10-9-38-11-13-41-14-12-38/h5-6,15-17H,7-14,18H2,1-4H3,(H,33,35,36,37) BRROKWAZCDMWEU-UHFFFAOYSA-N 444606 US10662186, Compound 153::US10988476, Compound I-153 Cyclin-dependent kinase 6 Homo sapiens 1.87 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444606&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196927 440706845 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907176 CN1CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)CC1 InChI=1S/C31H39F2N9/c1-20-35-29-23(32)16-22(17-26(29)42(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-7-6-21-19-41(9-8-25(21)36-27)15-14-40-12-10-39(5)11-13-40/h6-7,16-18H,8-15,19H2,1-5H3,(H,34,36,37,38) RHWIDIZNQRAAIU-UHFFFAOYSA-N 444607 US10662186, Compound 154::US10988476, Compound I-154 Cyclin-dependent kinase 6 Homo sapiens 1.97 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444607&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196899 440706846 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907179 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCP(C)(=O)CC4)CCc3n2)ncc1F InChI=1S/C31H39F2N8OP/c1-20-35-29-23(32)16-22(17-26(29)41(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-7-6-21-19-40(9-8-25(21)36-27)11-10-39-12-14-43(5,42)15-13-39/h6-7,16-18H,8-15,19H2,1-5H3,(H,34,36,37,38) WWPOWSOSERGQKM-UHFFFAOYSA-N 444608 US10662186, Compound 155::US10988476, Compound I-155 Cyclin-dependent kinase 6 Homo sapiens 2.08 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444608&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196893 440706847 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907182 CN(CCO)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8O/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-7-6-19-17-38(9-8-23(19)34-25)11-10-37(5)12-13-40/h6-7,14-16,40H,8-13,17H2,1-5H3,(H,32,34,35,36) GIOKUJORFDKSSG-UHFFFAOYSA-N 444609 US10662186, Compound 157::US10988476, Compound I-157 Cyclin-dependent kinase 6 Homo sapiens 2.03 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444609&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196902 440706848 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907185 CN(C)CCN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C31H41F2N9/c1-20-35-29-23(32)16-22(17-26(29)42(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-9-8-21-19-41(11-10-25(21)36-27)15-14-40(7)13-12-39(5)6/h8-9,16-18H,10-15,19H2,1-7H3,(H,34,36,37,38) FHUULRWYKIDOHF-UHFFFAOYSA-N 444610 US10662186, Compound 158::US10988476, Compound I-158 Cyclin-dependent kinase 6 Homo sapiens 1.60 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444610&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196900 440706849 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907188 CN(CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1)CC[Si](C)(C)C InChI=1S/C32H44F2N8Si/c1-21-36-30-24(33)17-23(18-27(30)42(21)32(2,3)4)29-25(34)19-35-31(39-29)38-28-10-9-22-20-41(12-11-26(22)37-28)14-13-40(5)15-16-43(6,7)8/h9-10,17-19H,11-16,20H2,1-8H3,(H,35,37,38,39) VVVCNCSCTHVHSD-UHFFFAOYSA-N 444611 US10662186, Compound 160::US10988476, Compound I-160 Cyclin-dependent kinase 6 Homo sapiens 2.46 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444611&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763681 440706850 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907191 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCNC(C)=N)CCc3n2)ncc1F InChI=1S/C27H31F2N9/c1-15(2)38-17(4)33-26-20(28)11-19(12-23(26)38)25-21(29)13-32-27(36-25)35-24-6-5-18-14-37(9-7-22(18)34-24)10-8-31-16(3)30/h5-6,11-13,15H,7-10,14H2,1-4H3,(H2,30,31)(H,32,34,35,36) ZTXZICVBZWFLGQ-UHFFFAOYSA-N 444612 US10662186, Compound 175::US10988476, Compound I-175 Cyclin-dependent kinase 6 Homo sapiens 3.86 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444612&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196748 440706851 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907194 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C27H32F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2,3)4)24-20(29)14-31-26(35-24)34-23-7-6-17-15-36(11-9-30-5)10-8-21(17)33-23/h6-7,12-14,30H,8-11,15H2,1-5H3,(H,31,33,34,35) NCAQSQYHTSCOCV-UHFFFAOYSA-N 444613 US10662186, Compound 176::US10988476, Compound I-176 Cyclin-dependent kinase 6 Homo sapiens 1.51 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444613&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196747 440706852 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907197 CN(C)C(C)(C)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C30H38F2N8/c1-18-34-27-21(31)13-20(14-24(27)40(18)29(2,3)4)26-22(32)15-33-28(37-26)36-25-10-9-19-16-39(12-11-23(19)35-25)17-30(5,6)38(7)8/h9-10,13-15H,11-12,16-17H2,1-8H3,(H,33,35,36,37) QCCNJYPQBCTGGP-UHFFFAOYSA-N 444614 US10662186, Compound 192::US10988476, Compound I-192 Cyclin-dependent kinase 6 Homo sapiens 1.53 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444614&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196789 440706853 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907200 CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) SESXHBRHIPVWPS-UHFFFAOYSA-N 444615 US10662186, Compound 196::US10988476, Compound I-196 Cyclin-dependent kinase 6 Homo sapiens 2.99 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444615&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196756 440706854 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907203 CN(CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1)CCP(O)(O)=O InChI=1S/C29H37F2N8O3P/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-7-6-19-17-38(9-8-23(19)34-25)11-10-37(5)12-13-43(40,41)42/h6-7,14-16H,8-13,17H2,1-5H3,(H2,40,41,42)(H,32,34,35,36) VSZKYBBLLRBZLS-UHFFFAOYSA-N 444616 US10662186, Compound 197::US10988476, Compound I-197 Cyclin-dependent kinase 6 Homo sapiens 12.9 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444616&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196803 440706855 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907206 CCOP(=O)(CCN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1)OCC InChI=1S/C33H45F2N8O3P/c1-8-45-47(44,46-9-2)17-16-41(7)14-15-42-13-12-27-23(21-42)10-11-29(38-27)39-32-36-20-26(35)30(40-32)24-18-25(34)31-28(19-24)43(22(3)37-31)33(4,5)6/h10-11,18-20H,8-9,12-17,21H2,1-7H3,(H,36,38,39,40) AWZRGPIFBNJODY-UHFFFAOYSA-N 444617 US10662186, Compound 198::US10988476, Compound I-198 Cyclin-dependent kinase 6 Homo sapiens 2.03 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444617&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196760 440706856 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907209 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CC(N)=NO)CCc3n2)ncc1F InChI=1S/C26H29F2N9O/c1-14-31-24-17(27)9-16(10-20(24)37(14)26(2,3)4)23-18(28)11-30-25(34-23)33-22-6-5-15-12-36(13-21(29)35-38)8-7-19(15)32-22/h5-6,9-11,38H,7-8,12-13H2,1-4H3,(H2,29,35)(H,30,32,33,34) GCELNWHYDYQJHB-UHFFFAOYSA-N 444618 US10662186, Compound 199::US10988476, Compound I-199 Cyclin-dependent kinase 6 Homo sapiens 2.31 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444618&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763683 440706857 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907212 CN(CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1)C(\C)=N/O InChI=1S/C29H35F2N9O/c1-17-33-27-21(30)13-20(14-24(27)40(17)29(3,4)5)26-22(31)15-32-28(36-26)35-25-8-7-19-16-39(10-9-23(19)34-25)12-11-38(6)18(2)37-41/h7-8,13-15,41H,9-12,16H2,1-6H3,(H,32,34,35,36)/b37-18- UEGPMXKTKCKXOK-AEVGBRMKSA-N 444619 US10662186, Compound 200 Cyclin-dependent kinase 6 Homo sapiens 5.89 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444619&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763689 440706858 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907215 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN)CCc3n2)ncc1F InChI=1S/C26H30F2N8/c1-15-31-24-18(27)11-17(12-21(24)36(15)26(2,3)4)23-19(28)13-30-25(34-23)33-22-6-5-16-14-35(10-8-29)9-7-20(16)32-22/h5-6,11-13H,7-10,14,29H2,1-4H3,(H,30,32,33,34) IWSDTEGBQVXXON-UHFFFAOYSA-N 444620 US10662186, Compound 202::US10988476, Compound I-202 Cyclin-dependent kinase 6 Homo sapiens 1.11 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444620&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196757 440706859 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907218 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2)7-8-27)24-20(29)14-31-26(35-24)34-23-5-4-17-15-36(11-9-30-3)10-6-21(17)33-23/h4-5,12-14,30H,6-11,15H2,1-3H3,(H,31,33,34,35) SAKHMWHBWMDUMO-UHFFFAOYSA-N 444621 US10662186, Compound 203::US10988476, Compound I-203 Cyclin-dependent kinase 6 Homo sapiens 1.28 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444621&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196758 440706860 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907221 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(=O)(CCN(C)(C)=O)CCc3n2)ncc1F InChI=1S/C27H30F2N8O2/c1-16-31-26-20(28)12-18(13-23(26)35(16)19-5-6-19)25-21(29)14-30-27(34-25)33-24-7-4-17-15-37(39,9-8-22(17)32-24)11-10-36(2,3)38/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,30,32,33,34) OFOKNGAIALWCMY-UHFFFAOYSA-N 444622 US10662186, Compound 204 Cyclin-dependent kinase 6 Homo sapiens 25.7 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444622&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196798 440706861 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907224 CCOP(=O)(OCC)N(C)CCN1(=O)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C30H39F2N8O4P/c1-7-43-45(42,44-8-2)38(6)12-14-40(41)13-11-25-21(18-40)9-10-27(35-25)36-30-33-17-24(32)28(37-30)22-15-23(31)29-26(16-22)39(19(3)4)20(5)34-29/h9-10,15-17,19H,7-8,11-14,18H2,1-6H3,(H,33,35,36,37) ZEBTXFXNRXGPKC-UHFFFAOYSA-N 444623 US10662186, Compound 205 Cyclin-dependent kinase 6 Homo sapiens 14.7 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444623&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802644 440706862 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907227 CC(CN(C)C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8/c1-17(15-37(6)7)38-11-10-23-19(16-38)8-9-25(34-23)35-28-32-14-22(31)26(36-28)20-12-21(30)27-24(13-20)39(18(2)33-27)29(3,4)5/h8-9,12-14,17H,10-11,15-16H2,1-7H3,(H,32,34,35,36) MDLZFWHQTJGZMT-UHFFFAOYSA-N 444624 US10662186, Compound 206::US10988476, Compound I-206 Cyclin-dependent kinase 6 Homo sapiens 1.76 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444624&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196762 440706863 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907230 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCC(=CC4)B(O)O)CCc3n2)ncc1F InChI=1S/C31H37BF2N8O2/c1-19-36-29-23(33)15-21(16-26(29)42(19)31(2,3)4)28-24(34)17-35-30(39-28)38-27-6-5-20-18-41(12-9-25(20)37-27)14-13-40-10-7-22(8-11-40)32(43)44/h5-7,15-17,43-44H,8-14,18H2,1-4H3,(H,35,37,38,39) ZSNPHFWSNIDXSN-UHFFFAOYSA-N 444625 US10662186, Compound 207::US10988476, Compound I-207 Cyclin-dependent kinase 6 Homo sapiens 1.73 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444625&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763678 440706864 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907233 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCS(C)(=O)=O)CCc3n2)ncc1F InChI=1S/C27H31F2N7O2S/c1-16-31-25-19(28)12-18(13-22(25)36(16)27(2,3)4)24-20(29)14-30-26(34-24)33-23-7-6-17-15-35(9-8-21(17)32-23)10-11-39(5,37)38/h6-7,12-14H,8-11,15H2,1-5H3,(H,30,32,33,34) SDAWBLGFXWXOCC-UHFFFAOYSA-N 444626 US10662186, Compound 208::US10988476, Compound I-208 Cyclin-dependent kinase 6 Homo sapiens 2.58 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444626&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196761 440706865 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907236 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CC=NO)CCc3n2)ncc1F InChI=1S/C26H28F2N8O/c1-15-31-24-18(27)11-17(12-21(24)36(15)26(2,3)4)23-19(28)13-29-25(34-23)33-22-6-5-16-14-35(10-8-30-37)9-7-20(16)32-22/h5-6,8,11-13,37H,7,9-10,14H2,1-4H3,(H,29,32,33,34)/b30-8+ OPZCPKBSWZFNRM-BEJOPBHTSA-N 444627 US10662186, Compound 209 Cyclin-dependent kinase 6 Homo sapiens 2.39 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444627&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763680 440706866 C02658 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907239 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CC(C)(C)N)CCc3n2)ncc1F InChI=1S/C28H34F2N8/c1-16-33-25-19(29)11-18(12-22(25)38(16)27(2,3)4)24-20(30)13-32-26(36-24)35-23-8-7-17-14-37(15-28(5,6)31)10-9-21(17)34-23/h7-8,11-13H,9-10,14-15,31H2,1-6H3,(H,32,34,35,36) POVBNEVJRAXZQO-UHFFFAOYSA-N 444628 US10662186, Compound 210::US10988476, Compound I-210 Cyclin-dependent kinase 6 Homo sapiens 1.80 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444628&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196755 440706867 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907242 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCC(CC4)B(O)O)CCc3n2)ncc1F InChI=1S/C31H39BF2N8O2/c1-19-36-29-23(33)15-21(16-26(29)42(19)31(2,3)4)28-24(34)17-35-30(39-28)38-27-6-5-20-18-41(12-9-25(20)37-27)14-13-40-10-7-22(8-11-40)32(43)44/h5-6,15-17,22,43-44H,7-14,18H2,1-4H3,(H,35,37,38,39) IRHOQMGOYMQRJB-UHFFFAOYSA-N 444629 US10662186, Compound 211::US10988476, Compound I-211 Cyclin-dependent kinase 6 Homo sapiens 1.36 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444629&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763677 440706868 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907245 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H23F2N7/c1-12(2)32-13(3)28-22-16(24)8-15(9-19(22)32)21-17(25)11-27-23(31-21)30-20-5-4-14-10-26-7-6-18(14)29-20/h4-5,8-9,11-12,26H,6-7,10H2,1-3H3,(H,27,29,30,31) HFKMNAUFISJBSK-UHFFFAOYSA-N 444486 US10662186, Compound 13::US10662186, Compound comparative A::US10988476, comparative example A Cyclin-dependent kinase 6 Homo sapiens 13.2 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444486&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118693642 440706734 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907248 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CO)ncc1F InChI=1S/C25H25F2N7O2/c1-13(2)34-14(3)29-24-17(26)8-16(9-20(24)34)23-18(27)10-28-25(32-23)31-21-5-4-15-11-33(22(36)12-35)7-6-19(15)30-21/h4-5,8-10,13,35H,6-7,11-12H2,1-3H3,(H,28,30,31,32) HLOKDQHOCMHLLI-UHFFFAOYSA-N 50458035 CHEMBL4213219::US10662186, Compound comparative B::US10988476, comparative example B Cyclin-dependent kinase 6 Homo sapiens 7.58 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458035&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118700794 433925300 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907251 COCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H29F2N7O/c1-15(2)35-16(3)30-25-19(27)11-18(12-22(25)35)24-20(28)13-29-26(33-24)32-23-6-5-17-14-34(9-10-36-4)8-7-21(17)31-23/h5-6,11-13,15H,7-10,14H2,1-4H3,(H,29,31,32,33) ROMAHJZEHBXJSU-UHFFFAOYSA-N 50458046 CHEMBL4213756::US10662186, Compound comparative C::US10988476, comparative example C Cyclin-dependent kinase 6 Homo sapiens 7.26 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458046&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118693641 433925311 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907254 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(C)=O)ncc1F InChI=1S/C25H25F2N7O/c1-13(2)34-14(3)29-24-18(26)9-17(10-21(24)34)23-19(27)11-28-25(32-23)31-22-6-5-16-12-33(15(4)35)8-7-20(16)30-22/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,28,30,31,32) AZENZYQBDCPVQO-UHFFFAOYSA-N 444633 US10662186, Compound comparative D::US10988476, comparative example D Cyclin-dependent kinase 6 Homo sapiens 7.22 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444633&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118700840 440706871 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907257 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCO)CCc3n2)ncc1F InChI=1S/C25H27F2N7O/c1-14(2)34-15(3)29-24-18(26)10-17(11-21(24)34)23-19(27)12-28-25(32-23)31-22-5-4-16-13-33(8-9-35)7-6-20(16)30-22/h4-5,10-12,14,35H,6-9,13H2,1-3H3,(H,28,30,31,32) ZAPGHPQYYDYEQW-UHFFFAOYSA-N 444634 US10662186, Compound comparative E::US10988476, comparative example E Cyclin-dependent kinase 6 Homo sapiens 9.17 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444634&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118693648 440706872 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907260 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCF)CCc3n2)ncc1F InChI=1S/C25H26F3N7/c1-14(2)35-15(3)30-24-18(27)10-17(11-21(24)35)23-19(28)12-29-25(33-23)32-22-5-4-16-13-34(9-7-26)8-6-20(16)31-22/h4-5,10-12,14H,6-9,13H2,1-3H3,(H,29,31,32,33) GZAGBRPFBCDRDL-UHFFFAOYSA-N 50458036 CHEMBL4207796::US10662186, Compound comparative F::US10988476, comparative example F Cyclin-dependent kinase 6 Homo sapiens 2.67 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458036&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118700782 433925301 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51252785 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2019.03.064 10.7270/Q27M0C84 30978559 Poratti, M; Marzaro, G University of Padova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51252786 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-dependent kinase 6 Homo sapiens 39 ChEMBL 10.1016/j.ejmech.2019.03.064 10.7270/Q27M0C84 30978559 Poratti, M; Marzaro, G University of Padova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51252805 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2019.03.064 10.7270/Q27M0C84 30978559 Poratti, M; Marzaro, G University of Padova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51251916 CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+ VXBAJLGYBMTJCY-NSCUHMNNSA-N 50363196 CHEMBL1944698 Cyclin-dependent kinase 6 Homo sapiens >100 ChEMBL 10.1021/acs.jmedchem.8b01469 10.7270/Q26Q21J2 30543440 Tadesse, S; Caldon, EC; Tilley, W; Wang, S University of South Australia Cancer Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363196&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 16739650 136967258 CHEMBL1944698 ZINC68251500 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906819 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 11.7 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906822 CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H29F2N7/c1-14(2)34-9-8-21-17(13-34)6-7-23(31-21)32-26-29-12-20(28)24(33-26)18-10-19(27)25-22(11-18)35(15(3)4)16(5)30-25/h6-7,10-12,14-15H,8-9,13H2,1-5H3,(H,29,31,32,33) XIVVCWMLPOQNDX-UHFFFAOYSA-N 444478 US10662186, Compound 3::US10988476, Compound I-3 Cyclin-dependent kinase 6 Homo sapiens 10.4 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444478&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196669 440706727 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906825 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H28F2N8O/c1-14(2)36-15(3)31-25-18(27)9-17(10-21(25)36)24-19(28)11-30-26(34-24)33-22-6-5-16-13-35(23(37)12-29-4)8-7-20(16)32-22/h5-6,9-11,14,29H,7-8,12-13H2,1-4H3,(H,30,32,33,34) DYNVDYWVVYCHHR-UHFFFAOYSA-N 444479 US10662186, Compound 4::US10662186, Compound 6::US10988476, Compound I-4 Cyclin-dependent kinase 6 Homo sapiens 3.49 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444479&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196660 440706728 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906828 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN(C)C)ncc1F InChI=1S/C27H30F2N8O/c1-15(2)37-16(3)31-26-19(28)10-18(11-22(26)37)25-20(29)12-30-27(34-25)33-23-7-6-17-13-36(9-8-21(17)32-23)24(38)14-35(4)5/h6-7,10-12,15H,8-9,13-14H2,1-5H3,(H,30,32,33,34) SSVSKCKWUAPYHI-UHFFFAOYSA-N 50458034 CHEMBL4212532::US10662186, Compound 5::US10988476, Compound I-5 Cyclin-dependent kinase 6 Homo sapiens 4.14 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458034&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114516 433925299 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906831 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H28F2N8O/c1-14(2)36-15(3)31-25-18(27)9-17(10-21(25)36)24-19(28)11-30-26(34-24)33-22-6-5-16-13-35(23(37)12-29-4)8-7-20(16)32-22/h5-6,9-11,14,29H,7-8,12-13H2,1-4H3,(H,30,32,33,34) DYNVDYWVVYCHHR-UHFFFAOYSA-N 444479 US10662186, Compound 4::US10662186, Compound 6::US10988476, Compound I-4 Cyclin-dependent kinase 6 Homo sapiens 7.57 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444479&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196660 440706728 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906834 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C)CCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13(2)33-14(3)28-23-17(25)9-16(10-20(23)33)22-18(26)11-27-24(31-22)30-21-6-5-15-12-32(4)8-7-19(15)29-21/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,27,29,30,31) AXTGGTFVALFVDO-UHFFFAOYSA-N 444482 US10662186, Compound 8::US10988476, Compound I-8 Cyclin-dependent kinase 6 Homo sapiens 7.07 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444482&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196664 440706730 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906837 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CCO)ncc1F InChI=1S/C26H27F2N7O2/c1-14(2)35-15(3)30-25-18(27)10-17(11-21(25)35)24-19(28)12-29-26(33-24)32-22-5-4-16-13-34(23(37)7-9-36)8-6-20(16)31-22/h4-5,10-12,14,36H,6-9,13H2,1-3H3,(H,29,31,32,33) JDIAYVMOUUKPNK-UHFFFAOYSA-N 444483 US10662186, Compound 9::US10988476, Compound I-9 Cyclin-dependent kinase 6 Homo sapiens 7.09 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444483&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196659 440706731 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906840 COC(=O)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H25F2N7O3/c1-13(2)35-14(3)30-23-17(27)9-16(10-20(23)35)22-18(28)11-29-26(33-22)32-21-6-5-15-12-34(8-7-19(15)31-21)24(36)25(37)38-4/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,29,31,32,33) HVTYFANOGPVRAE-UHFFFAOYSA-N 444484 US10662186, Compound 10::US10988476, Compound I-10 Cyclin-dependent kinase 6 Homo sapiens 7.81 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444484&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196670 440706732 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906843 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC(F)(F)F)CCc3n2)ncc1F InChI=1S/C25H24F5N7/c1-13(2)37-14(3)32-23-17(26)8-16(9-20(23)37)22-18(27)10-31-24(35-22)34-21-5-4-15-11-36(12-25(28,29)30)7-6-19(15)33-21/h4-5,8-10,13H,6-7,11-12H2,1-3H3,(H,31,33,34,35) XFNINEDWLFKZMH-UHFFFAOYSA-N 444485 US10662186, Compound 12::US10988476, Compound I-12 Cyclin-dependent kinase 6 Homo sapiens 14.2 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444485&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114456 440706733 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906846 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H23F2N7/c1-12(2)32-13(3)28-22-16(24)8-15(9-19(22)32)21-17(25)11-27-23(31-21)30-20-5-4-14-10-26-7-6-18(14)29-20/h4-5,8-9,11-12,26H,6-7,10H2,1-3H3,(H,27,29,30,31) HFKMNAUFISJBSK-UHFFFAOYSA-N 444486 US10662186, Compound 13::US10662186, Compound comparative A::US10988476, comparative example A Cyclin-dependent kinase 6 Homo sapiens 327 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444486&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118693642 440706734 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906849 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=C)CN(C)C)ncc1F InChI=1S/C28H32F2N8/c1-16(2)38-18(4)32-27-21(29)11-20(12-24(27)38)26-22(30)13-31-28(35-26)34-25-8-7-19-15-37(10-9-23(19)33-25)17(3)14-36(5)6/h7-8,11-13,16H,3,9-10,14-15H2,1-2,4-6H3,(H,31,33,34,35) VOZSBSGPEIZDAJ-UHFFFAOYSA-N 444487 US10662186, Compound 14 Cyclin-dependent kinase 6 Homo sapiens 140 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444487&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802628 440706735 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906852 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3C(=O)N(CCN(C)C)Cc3n2)ncc1F InChI=1S/C26H28F2N8O/c1-14(2)36-15(3)30-24-18(27)10-16(11-21(24)36)23-19(28)12-29-26(33-23)32-22-7-6-17-20(31-22)13-35(25(17)37)9-8-34(4)5/h6-7,10-12,14H,8-9,13H2,1-5H3,(H,29,31,32,33) UNSAZGGWYRHTHJ-UHFFFAOYSA-N 444488 US10662186, Compound 15::US10988476, Compound I-15 Cyclin-dependent kinase 6 Homo sapiens 113 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444488&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196668 440706736 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906855 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CC(CCc3n2)C(=O)CN)ncc1F InChI=1S/C26H27F2N7O/c1-13(2)35-14(3)31-25-18(27)9-17(10-21(25)35)24-19(28)12-30-26(34-24)33-23-7-5-15-8-16(22(36)11-29)4-6-20(15)32-23/h5,7,9-10,12-13,16H,4,6,8,11,29H2,1-3H3,(H,30,32,33,34) LKPSCTJYYAVIIL-UHFFFAOYSA-N 444489 US10662186, Compound 17 Cyclin-dependent kinase 6 Homo sapiens 4.88 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444489&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802629 440706737 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906858 COC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C25H25F2N7O2/c1-13(2)34-14(3)29-23-17(26)9-16(10-20(23)34)22-18(27)11-28-24(32-22)31-21-6-5-15-12-33(25(35)36-4)8-7-19(15)30-21/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,28,30,31,32) SQAZXWOTKSSCBZ-UHFFFAOYSA-N 444490 US10662186, Compound 19 Cyclin-dependent kinase 6 Homo sapiens 12.4 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444490&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802630 440706738 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906861 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(O)=O)ncc1F InChI=1S/C24H23F2N7O2/c1-12(2)33-13(3)28-22-16(25)8-15(9-19(22)33)21-17(26)10-27-23(31-21)30-20-5-4-14-11-32(24(34)35)7-6-18(14)29-20/h4-5,8-10,12H,6-7,11H2,1-3H3,(H,34,35)(H,27,29,30,31) BVZZSEVVEDNIOM-UHFFFAOYSA-N 444491 US10662186, Compound 20 Cyclin-dependent kinase 6 Homo sapiens 22.3 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444491&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802631 440706739 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906864 Cc1nc2c(F)cc(cc2n1C1CCCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H25F2N7/c1-14-30-24-18(26)10-16(11-21(24)34(14)17-4-2-3-5-17)23-19(27)13-29-25(33-23)32-22-7-6-15-12-28-9-8-20(15)31-22/h6-7,10-11,13,17,28H,2-5,8-9,12H2,1H3,(H,29,31,32,33) WCEJWHANTHYYCV-UHFFFAOYSA-N 444492 US10662186, Compound 21::US10988476, Compound I-21 Cyclin-dependent kinase 6 Homo sapiens 25.0 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444492&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114422 440706740 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906867 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-17-33-28-21(30)12-19(13-24(28)39(17)20-6-4-5-7-20)27-22(31)14-32-29(36-27)35-25-9-8-18-15-38(11-10-23(18)34-25)26(40)16-37(2)3/h8-9,12-14,20H,4-7,10-11,15-16H2,1-3H3,(H,32,34,35,36) ZFXSUJXETQKSKI-UHFFFAOYSA-N 444493 US10662186, Compound 22::US10988476, Compound I-22 Cyclin-dependent kinase 6 Homo sapiens 10.6 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444493&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196666 440706741 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906870 CN1CCN(CC(=C)N2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(C6CCCC6)c5c4)ccc3C2)CC1 InChI=1S/C33H39F2N9/c1-21(19-42-14-12-41(3)13-15-42)43-11-10-28-23(20-43)8-9-30(38-28)39-33-36-18-27(35)31(40-33)24-16-26(34)32-29(17-24)44(22(2)37-32)25-6-4-5-7-25/h8-9,16-18,25H,1,4-7,10-15,19-20H2,2-3H3,(H,36,38,39,40) FGFWZFYILZKNBW-UHFFFAOYSA-N 444494 US10662186, Compound 23 Cyclin-dependent kinase 6 Homo sapiens 4.17 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444494&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802632 440706742 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906873 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCOCC2)ncc1F InChI=1S/C29H32F2N8O2/c1-17(2)39-18(3)33-28-21(30)12-20(13-24(28)39)27-22(31)14-32-29(36-27)35-25-5-4-19-15-38(7-6-23(19)34-25)26(40)16-37-8-10-41-11-9-37/h4-5,12-14,17H,6-11,15-16H2,1-3H3,(H,32,34,35,36) HXKORJQOSCRLJP-UHFFFAOYSA-N 444495 US10662186, Compound 24::US10988476, Compound I-24 Cyclin-dependent kinase 6 Homo sapiens 6.44 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444495&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114319 440706743 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906876 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C(C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35) SSIOYGMEKCPFAV-UHFFFAOYSA-N 444496 US10662186, Compound 25::US10988476, Compound I-25 Cyclin-dependent kinase 6 Homo sapiens 5.78 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444496&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196667 440706744 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906879 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CC(C)(C)O)ncc1F InChI=1S/C28H31F2N7O2/c1-15(2)37-16(3)32-26-19(29)10-18(11-22(26)37)25-20(30)13-31-27(35-25)34-23-7-6-17-14-36(9-8-21(17)33-23)24(38)12-28(4,5)39/h6-7,10-11,13,15,39H,8-9,12,14H2,1-5H3,(H,31,33,34,35) DHMHGKLKKIGMHX-UHFFFAOYSA-N 444498 US10662186, Compound 26::US10988476, Compound I-26 Cyclin-dependent kinase 6 Homo sapiens 8.12 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444498&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196671 440706746 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906882 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C(C)(C)N(C)C)ncc1F InChI=1S/C29H34F2N8O/c1-16(2)39-17(3)33-26-20(30)12-19(13-23(26)39)25-21(31)14-32-28(36-25)35-24-9-8-18-15-38(11-10-22(18)34-24)27(40)29(4,5)37(6)7/h8-9,12-14,16H,10-11,15H2,1-7H3,(H,32,34,35,36) DNFNQGHGGVBVSY-UHFFFAOYSA-N 444499 US10662186, Compound 27::US10988476, Compound I-27 Cyclin-dependent kinase 6 Homo sapiens 14.1 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444499&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196846 440706747 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906885 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H21F2N7/c1-12-28-22-16(24)8-14(9-19(22)32(12)15-3-4-15)21-17(25)11-27-23(31-21)30-20-5-2-13-10-26-7-6-18(13)29-20/h2,5,8-9,11,15,26H,3-4,6-7,10H2,1H3,(H,27,29,30,31) GJEWTVQXBHSVAU-UHFFFAOYSA-N 444500 US10662186, Compound 28::US10988476, Compound I-28 Cyclin-dependent kinase 6 Homo sapiens 18.9 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444500&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196743 440706748 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906888 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-31-26-19(28)10-17(11-22(26)37(15)18-5-6-18)25-20(29)12-30-27(34-25)33-23-7-4-16-13-36(9-8-21(16)32-23)24(38)14-35(2)3/h4,7,10-12,18H,5-6,8-9,13-14H2,1-3H3,(H,30,32,33,34) OIQZLVBXHSEFQP-UHFFFAOYSA-N 444501 US10662186, Compound 29::US10662186, Compound 37::US10662186, Compound 64::US10988476, Compound I-29 Cyclin-dependent kinase 6 Homo sapiens 4.98 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444501&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196847 440706749 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906891 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCCCC2)ncc1F InChI=1S/C30H32F2N8O/c1-18-34-29-22(31)13-20(14-25(29)40(18)21-6-7-21)28-23(32)15-33-30(37-28)36-26-8-5-19-16-39(12-9-24(19)35-26)27(41)17-38-10-3-2-4-11-38/h5,8,13-15,21H,2-4,6-7,9-12,16-17H2,1H3,(H,33,35,36,37) ZUOVZWHQGAJGQA-UHFFFAOYSA-N 444502 US10662186, Compound 30 Cyclin-dependent kinase 6 Homo sapiens 3.38 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444502&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802633 440706750 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906894 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CC2CC(O)C2)ncc1F InChI=1S/C29H29F2N7O2/c1-15-33-28-21(30)11-18(12-24(28)38(15)19-3-4-19)27-22(31)13-32-29(36-27)35-25-5-2-17-14-37(7-6-23(17)34-25)26(40)10-16-8-20(39)9-16/h2,5,11-13,16,19-20,39H,3-4,6-10,14H2,1H3,(H,32,34,35,36) YYWWXDBYEUYMKM-UHFFFAOYSA-N 444503 US10662186, Compound 31 Cyclin-dependent kinase 6 Homo sapiens 4.84 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444503&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802634 440706751 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906897 Cc1nc2c(F)cc(cc2n1C1CCCCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C26H27F2N7/c1-15-31-25-19(27)11-17(12-22(25)35(15)18-5-3-2-4-6-18)24-20(28)14-30-26(34-24)33-23-8-7-16-13-29-10-9-21(16)32-23/h7-8,11-12,14,18,29H,2-6,9-10,13H2,1H3,(H,30,32,33,34) UJHKKNOWOJMKCR-UHFFFAOYSA-N 444504 US10662186, Compound 32::US10988476, Compound I-32 Cyclin-dependent kinase 6 Homo sapiens 13.2 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444504&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196738 440706752 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906900 C[C@H]1CCC(CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C27H29F2N7/c1-15-3-6-19(7-4-15)36-16(2)32-26-20(28)11-18(12-23(26)36)25-21(29)14-31-27(35-25)34-24-8-5-17-13-30-10-9-22(17)33-24/h5,8,11-12,14-15,19,30H,3-4,6-7,9-10,13H2,1-2H3,(H,31,33,34,35)/t15-,19? JAZHDXRHOSJZHB-XIRXVJAISA-N 444505 US10662186, Compound 33::US10988476, Compound I-33 Cyclin-dependent kinase 6 Homo sapiens 6.23 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444505&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196845 440706753 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906903 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC[C@H](C)CC5)c4c3)ccc2C1 InChI=1S/C30H34F2N8O/c1-17-4-7-21(8-5-17)40-18(2)35-29-22(31)12-20(13-25(29)40)28-23(32)14-34-30(38-28)37-26-9-6-19-16-39(27(41)15-33-3)11-10-24(19)36-26/h6,9,12-14,17,21,33H,4-5,7-8,10-11,15-16H2,1-3H3,(H,34,36,37,38)/t17-,21? CVNQRFZZFGTWIK-KJPGQXGLSA-N 444507 US10662186, Compound 34::US10988476, Compound I-34 Cyclin-dependent kinase 6 Homo sapiens 2.56 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444507&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196844 440706755 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906906 C[C@H]1CCC(CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN(C)C)ncc1F InChI=1S/C31H36F2N8O/c1-18-5-8-22(9-6-18)41-19(2)35-30-23(32)13-21(14-26(30)41)29-24(33)15-34-31(38-29)37-27-10-7-20-16-40(12-11-25(20)36-27)28(42)17-39(3)4/h7,10,13-15,18,22H,5-6,8-9,11-12,16-17H2,1-4H3,(H,34,36,37,38)/t18-,22? YERVFCNDCWMBBO-ZKCBWYJKSA-N 444510 US10662186, Compound 35::US10988476, Compound I-35 Cyclin-dependent kinase 6 Homo sapiens 4.53 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444510&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196839 440706758 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906909 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCCC5)c4c3)ccc2C1 InChI=1S/C30H34F2N8O/c1-18-34-29-22(31)13-20(14-25(29)40(18)21-7-5-4-6-8-21)28-23(32)15-33-30(37-28)36-26-10-9-19-16-39(12-11-24(19)35-26)27(41)17-38(2)3/h9-10,13-15,21H,4-8,11-12,16-17H2,1-3H3,(H,33,35,36,37) HCCNJLKJQAHREN-UHFFFAOYSA-N 444512 US10662186, Compound 36::US10988476, Compound I-36 Cyclin-dependent kinase 6 Homo sapiens 7.41 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444512&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196843 440706760 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906912 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-31-26-19(28)10-17(11-22(26)37(15)18-5-6-18)25-20(29)12-30-27(34-25)33-23-7-4-16-13-36(9-8-21(16)32-23)24(38)14-35(2)3/h4,7,10-12,18H,5-6,8-9,13-14H2,1-3H3,(H,30,32,33,34) OIQZLVBXHSEFQP-UHFFFAOYSA-N 444501 US10662186, Compound 29::US10662186, Compound 37::US10662186, Compound 64::US10988476, Compound I-29 Cyclin-dependent kinase 6 Homo sapiens 16.1 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444501&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196847 440706749 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906915 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C=C)ncc1F InChI=1S/C26H25F2N7O/c1-5-23(36)34-9-8-20-16(13-34)6-7-22(31-20)32-26-29-12-19(28)24(33-26)17-10-18(27)25-21(11-17)35(14(2)3)15(4)30-25/h5-7,10-12,14H,1,8-9,13H2,2-4H3,(H,29,31,32,33) SOHOEERULHWXJB-UHFFFAOYSA-N 444516 US10662186, Compound 38::US10988476, Compound I-38 Cyclin-dependent kinase 6 Homo sapiens 4.37 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444516&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114603 440706763 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906918 Cc1nc2c(F)cc(cc2n1C1CCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H23F2N7/c1-13-29-23-17(25)9-15(10-20(23)33(13)16-3-2-4-16)22-18(26)12-28-24(32-22)31-21-6-5-14-11-27-8-7-19(14)30-21/h5-6,9-10,12,16,27H,2-4,7-8,11H2,1H3,(H,28,30,31,32) SVXDTIUTCGVODS-UHFFFAOYSA-N 444518 US10662186, Compound 39::US10988476, Compound I-39 Cyclin-dependent kinase 6 Homo sapiens 7.43 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444518&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114305 440706765 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906921 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CC(N)C2)ncc1F InChI=1S/C28H30F2N8O/c1-14(2)38-15(3)33-26-20(29)10-17(11-23(26)38)25-21(30)12-32-28(36-25)35-24-5-4-16-13-37(7-6-22(16)34-24)27(39)18-8-19(31)9-18/h4-5,10-12,14,18-19H,6-9,13,31H2,1-3H3,(H,32,34,35,36) MZGANASDMYZAGW-UHFFFAOYSA-N 444519 US10662186, Compound 40::US10988476, Compound I-40 Cyclin-dependent kinase 6 Homo sapiens 3.59 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444519&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196822 440706766 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906924 CC(C)n1c(C)nc2c(cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F)C(F)(F)F InChI=1S/C24H23F4N7/c1-12(2)35-13(3)31-22-16(24(26,27)28)8-15(9-19(22)35)21-17(25)11-30-23(34-21)33-20-5-4-14-10-29-7-6-18(14)32-20/h4-5,8-9,11-12,29H,6-7,10H2,1-3H3,(H,30,32,33,34) IYUGPEZCKNVRDO-UHFFFAOYSA-N 444520 US10662186, Compound 41::US10988476, Compound I-41 Cyclin-dependent kinase 6 Homo sapiens 272 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444520&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763691 440706767 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906927 CNC1CC(C1)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-15(2)39-16(3)34-27-21(30)11-18(12-24(27)39)26-22(31)13-33-29(37-26)36-25-6-5-17-14-38(8-7-23(17)35-25)28(40)19-9-20(10-19)32-4/h5-6,11-13,15,19-20,32H,7-10,14H2,1-4H3,(H,33,35,36,37) JNCFUVQWIVLATB-UHFFFAOYSA-N 444521 US10662186, Compound 42::US10988476, Compound I-42 Cyclin-dependent kinase 6 Homo sapiens 13.4 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444521&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196823 440706768 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906930 CN(C)CCNC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H31F2N9O/c1-16-33-26-20(29)12-18(13-23(26)39(16)19-5-6-19)25-21(30)14-32-27(36-25)35-24-7-4-17-15-38(10-8-22(17)34-24)28(40)31-9-11-37(2)3/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,31,40)(H,32,34,35,36) ISWNVTVWJJQFQV-UHFFFAOYSA-N 444522 US10662186, Compound 43::US10988476, Compound I-43 Cyclin-dependent kinase 6 Homo sapiens 3.57 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444522&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196831 440706769 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906933 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCN(C)C)ncc1F InChI=1S/C28H33F2N9O/c1-16(2)39-17(3)33-26-20(29)12-19(13-23(26)39)25-21(30)14-32-27(36-25)35-24-7-6-18-15-38(10-8-22(18)34-24)28(40)31-9-11-37(4)5/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,31,40)(H,32,34,35,36) SALMKXDVOXFTFG-UHFFFAOYSA-N 444523 US10662186, Compound 44::US10988476, Compound I-44 Cyclin-dependent kinase 6 Homo sapiens 2.82 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444523&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196817 440706770 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906936 CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) JZGPEQNPASOUFO-UHFFFAOYSA-N 444524 US10662186, Compound 45::US10988476, Compound I-45 Cyclin-dependent kinase 6 Homo sapiens 22.7 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444524&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196815 440706771 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906939 CN(C)CCOC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O2/c1-16-32-26-20(29)12-18(13-23(26)38(16)19-5-6-19)25-21(30)14-31-27(35-25)34-24-7-4-17-15-37(9-8-22(17)33-24)28(39)40-11-10-36(2)3/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,31,33,34,35) XLZHLULRODUOPS-UHFFFAOYSA-N 444525 US10662186, Compound 46::US10988476, Compound I-46 Cyclin-dependent kinase 6 Homo sapiens 3.42 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444525&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196818 440706772 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906942 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 6 Homo sapiens 4.16 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906945 C[C@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m0/s1 IIHKFIWSMAISST-HNNXBMFYSA-N 444528 US10662186, Compound 48::US10988476, Compound I-48 Cyclin-dependent kinase 6 Homo sapiens 4.88 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444528&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196802 440706775 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906948 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) VZPLQNFSKCQLPB-UHFFFAOYSA-N 444529 US10662186, Compound 49::US10988476, Compound I-49 Cyclin-dependent kinase 6 Homo sapiens 5.17 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444529&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196801 440706776 C04080 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906951 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F InChI=1S/C26H26F2N8O2/c1-14-31-24-18(27)10-16(11-21(24)36(14)17-3-4-17)23-19(28)12-30-25(34-23)33-22-5-2-15-13-35(8-6-20(15)32-22)26(38)29-7-9-37/h2,5,10-12,17,37H,3-4,6-9,13H2,1H3,(H,29,38)(H,30,32,33,34) XTSFMAFWRLGELC-UHFFFAOYSA-N 444530 US10662186, Compound 50::US10988476, Compound I-50 Cyclin-dependent kinase 6 Homo sapiens 3.94 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444530&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196796 440706777 C04080 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906954 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-32-26-19(28)10-17(11-22(26)37(15)18-4-3-5-18)25-20(29)12-31-27(35-25)34-23-7-6-16-14-36(24(38)13-30-2)9-8-21(16)33-23/h6-7,10-12,18,30H,3-5,8-9,13-14H2,1-2H3,(H,31,33,34,35) UTDIUAOBXDHROL-UHFFFAOYSA-N 444531 US10662186, Compound 51::US10988476, Compound I-51 Cyclin-dependent kinase 6 Homo sapiens 2.88 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444531&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196799 440706778 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906957 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-31-26-20(28)12-18(13-23(26)37(16)19-5-6-19)25-21(29)14-30-27(34-25)33-24-7-4-17-15-36(11-10-35(2)3)9-8-22(17)32-24/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,30,32,33,34) UZUCFTPPULEGQO-UHFFFAOYSA-N 444532 US10662186, Compound 52::US10988476, Compound I-52 Cyclin-dependent kinase 6 Homo sapiens 3.81 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444532&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196740 440706779 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906960 CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)12-18(13-23(27)38(16)19-5-6-19)26-21(30)14-31-28(35-26)34-24-7-4-17-15-37(11-8-22(17)33-24)25(39)9-10-36(2)3/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,31,33,34,35) SZRLOUJSZUQGCD-UHFFFAOYSA-N 444533 US10662186, Compound 53 Cyclin-dependent kinase 6 Homo sapiens 5.46 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444533&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196797 440706780 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906963 CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-17-33-28-21(30)13-19(14-24(28)39(17)20-5-4-6-20)27-22(31)15-32-29(36-27)35-25-8-7-18-16-38(12-9-23(18)34-25)26(40)10-11-37(2)3/h7-8,13-15,20H,4-6,9-12,16H2,1-3H3,(H,32,34,35,36) CJOCXJOHQLURIU-UHFFFAOYSA-N 444534 US10662186, Compound 54 Cyclin-dependent kinase 6 Homo sapiens 7.50 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444534&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763676 440706781 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906966 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CC(C2)N(C)C)ncc1F InChI=1S/C30H34F2N8O/c1-16(2)40-17(3)34-28-22(31)12-19(13-25(28)40)27-23(32)14-33-30(37-27)36-26-7-6-18-15-39(9-8-24(18)35-26)29(41)20-10-21(11-20)38(4)5/h6-7,12-14,16,20-21H,8-11,15H2,1-5H3,(H,33,35,36,37) JDVCOPUEQIAVNW-UHFFFAOYSA-N 444535 US10662186, Compound 55 Cyclin-dependent kinase 6 Homo sapiens 3.56 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444535&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196816 440706782 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906969 Cc1nc2c(F)cc(cc2n1CC1CC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H23F2N7/c1-13-29-23-17(25)8-16(9-20(23)33(13)12-14-2-3-14)22-18(26)11-28-24(32-22)31-21-5-4-15-10-27-7-6-19(15)30-21/h4-5,8-9,11,14,27H,2-3,6-7,10,12H2,1H3,(H,28,30,31,32) SWHALWMKROAPPG-UHFFFAOYSA-N 444537 US10662186, Compound 57 Cyclin-dependent kinase 6 Homo sapiens 6.14 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444537&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196819 440706784 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906972 CN1CCC[C@@H]1C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H30F2N8O/c1-16-33-27-20(30)12-18(13-24(27)39(16)19-6-7-19)26-21(31)14-32-29(36-26)35-25-8-5-17-15-38(11-9-22(17)34-25)28(40)23-4-3-10-37(23)2/h5,8,12-14,19,23H,3-4,6-7,9-11,15H2,1-2H3,(H,32,34,35,36)/t23-/m1/s1 KYMNNSMBWCZWCF-HSZRJFAPSA-N 444538 US10662186, Compound 58 Cyclin-dependent kinase 6 Homo sapiens 6.14 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444538&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196826 440706785 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906975 CN1CCC[C@H]1C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H30F2N8O/c1-16-33-27-20(30)12-18(13-24(27)39(16)19-6-7-19)26-21(31)14-32-29(36-26)35-25-8-5-17-15-38(11-9-22(17)34-25)28(40)23-4-3-10-37(23)2/h5,8,12-14,19,23H,3-4,6-7,9-11,15H2,1-2H3,(H,32,34,35,36)/t23-/m0/s1 KYMNNSMBWCZWCF-QHCPKHFHSA-N 444539 US10662186, Compound 59 Cyclin-dependent kinase 6 Homo sapiens 4.78 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444539&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196820 440706786 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906978 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)10-19(11-23(27)38(16)13-17-4-5-17)26-21(30)12-31-28(35-26)34-24-7-6-18-14-37(9-8-22(18)33-24)25(39)15-36(2)3/h6-7,10-12,17H,4-5,8-9,13-15H2,1-3H3,(H,31,33,34,35) FEBXDTFBHZJUJT-UHFFFAOYSA-N 444540 US10662186, Compound 60::US10988476, Compound I-60 Cyclin-dependent kinase 6 Homo sapiens 3.47 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444540&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196821 440706787 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906981 CN(C)CCN(C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H33F2N9O/c1-17-33-27-21(30)13-19(14-24(27)40(17)20-6-7-20)26-22(31)15-32-28(36-26)35-25-8-5-18-16-39(10-9-23(18)34-25)29(41)38(4)12-11-37(2)3/h5,8,13-15,20H,6-7,9-12,16H2,1-4H3,(H,32,34,35,36) IVKYJVDFJKEXIH-UHFFFAOYSA-N 444541 US10662186, Compound 61::US10988476, Compound I-61 Cyclin-dependent kinase 6 Homo sapiens 2.55 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444541&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196824 440706788 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906984 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)[C@@H](C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35)/t16-/m1/s1 SSIOYGMEKCPFAV-MRXNPFEDSA-N 444542 US10662186, Compound 62::US10988476, Compound I-62 Cyclin-dependent kinase 6 Homo sapiens 4.51 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444542&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196777 440706789 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906987 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C27H32F2N8/c1-16(2)37-17(3)31-26-20(28)12-19(13-23(26)37)25-21(29)14-30-27(34-25)33-24-7-6-18-15-36(11-10-35(4)5)9-8-22(18)32-24/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,30,32,33,34) KGMVZSJAPXYTKH-UHFFFAOYSA-N 444543 US10662186, Compound 63::US10988476, Compound I-63 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444543&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196825 440706790 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906990 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-31-26-19(28)10-17(11-22(26)37(15)18-5-6-18)25-20(29)12-30-27(34-25)33-23-7-4-16-13-36(9-8-21(16)32-23)24(38)14-35(2)3/h4,7,10-12,18H,5-6,8-9,13-14H2,1-3H3,(H,30,32,33,34) OIQZLVBXHSEFQP-UHFFFAOYSA-N 444501 US10662186, Compound 29::US10662186, Compound 37::US10662186, Compound 64::US10988476, Compound I-29 Cyclin-dependent kinase 6 Homo sapiens 8.47 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444501&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196847 440706749 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906993 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36) QXBRBWDRQIISAT-UHFFFAOYSA-N 444545 US10662186, Compound 65::US10662186, Compound 67::US10988476, Compound I-65 Cyclin-dependent kinase 6 Homo sapiens 3.75 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444545&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196850 440706791 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906996 CN[C@H](C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-14(30-3)26(38)36-9-8-21-16(13-36)4-7-23(33-21)34-27-31-12-20(29)24(35-27)17-10-19(28)25-22(11-17)37(15(2)32-25)18-5-6-18/h4,7,10-12,14,18,30H,5-6,8-9,13H2,1-3H3,(H,31,33,34,35)/t14-/m1/s1 PMCGYDRAUVMLBE-CQSZACIVSA-N 444546 US10662186, Compound 66::US10988476, Compound I-66 Cyclin-dependent kinase 6 Homo sapiens 6.36 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444546&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196853 440706792 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 906999 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36) QXBRBWDRQIISAT-UHFFFAOYSA-N 444545 US10662186, Compound 65::US10662186, Compound 67::US10988476, Compound I-65 Cyclin-dependent kinase 6 Homo sapiens 6.24 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444545&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196850 440706791 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907002 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2,3)4)21-17(26)12-28-23(32-21)31-20-6-5-14-11-27-8-7-18(14)30-20/h5-6,9-10,12,27H,7-8,11H2,1-4H3,(H,28,30,31,32) LIJUCWLALFXGCL-UHFFFAOYSA-N 444548 US10662186, Compound 68::US10988476, Compound I-68 Cyclin-dependent kinase 6 Homo sapiens 2.97 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444548&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196856 440706793 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907005 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C28H34F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2,3)4)25-21(30)15-31-27(35-25)34-24-8-7-18-16-37(12-11-36(5)6)10-9-22(18)33-24/h7-8,13-15H,9-12,16H2,1-6H3,(H,31,33,34,35) AKGTYSYXMRZPBV-UHFFFAOYSA-N 444549 US10662186, Compound 69::US10988476, Compound I-69 Cyclin-dependent kinase 6 Homo sapiens 1.57 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444549&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196857 440706794 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907008 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)13-19(14-24(27)38(17)20-6-7-20)26-22(30)15-31-28(35-26)34-25-8-5-18-16-37(11-4-10-36(2)3)12-9-23(18)33-25/h5,8,13-15,20H,4,6-7,9-12,16H2,1-3H3,(H,31,33,34,35) GYDXFTMHNUETBY-UHFFFAOYSA-N 444550 US10662186, Compound 70::US10988476, Compound I-70 Cyclin-dependent kinase 6 Homo sapiens 5.51 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444550&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196851 440706795 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907011 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CC#C)CCc3n2)ncc1F InChI=1S/C29H32F2N8/c1-6-10-37(5)12-13-38-11-9-24-20(17-38)7-8-26(34-24)35-29-32-16-23(31)27(36-29)21-14-22(30)28-25(15-21)39(18(2)3)19(4)33-28/h1,7-8,14-16,18H,9-13,17H2,2-5H3,(H,32,34,35,36) UGMXVKWXOFIULK-UHFFFAOYSA-N 444551 US10662186, Compound 71::US10988476, Compound I-71 Cyclin-dependent kinase 6 Homo sapiens 3.47 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444551&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196855 440706796 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907014 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C2CCN(C2)C#C)ncc1F InChI=1S/C29H30F2N8/c1-5-37-10-8-21(16-37)38-11-9-24-19(15-38)6-7-26(34-24)35-29-32-14-23(31)27(36-29)20-12-22(30)28-25(13-20)39(17(2)3)18(4)33-28/h1,6-7,12-14,17,21H,8-11,15-16H2,2-4H3,(H,32,34,35,36) ZJXAYHKSLDKUOY-UHFFFAOYSA-N 444552 US10662186, Compound 72 Cyclin-dependent kinase 6 Homo sapiens 2.58 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444552&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155802642 440706797 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907017 CN(C)C[C@H](O)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8O/c1-16-32-27-21(29)10-18(11-24(27)38(16)19-5-6-19)26-22(30)12-31-28(35-26)34-25-7-4-17-13-37(9-8-23(17)33-25)15-20(39)14-36(2)3/h4,7,10-12,19-20,39H,5-6,8-9,13-15H2,1-3H3,(H,31,33,34,35)/t20-/m0/s1 UQAHWAQRLXARGK-FQEVSTJZSA-N 444554 US10662186, Compound 73::US10988476, Compound I-73 Cyclin-dependent kinase 6 Homo sapiens 6.91 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444554&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196741 440706799 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907020 CN1CCC[C@@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m1/s1 DSMBDRWDECFDNR-OAQYLSRUSA-N 444555 US10662186, Compound 74::US10988476, Compound I-74 Cyclin-dependent kinase 6 Homo sapiens 3.15 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444555&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196858 440706800 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907023 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC4CCCN4CC#C)CCc3n2)ncc1F InChI=1S/C31H34F2N8/c1-5-11-40-12-6-7-23(40)18-39-13-10-26-21(17-39)8-9-28(36-26)37-31-34-16-25(33)29(38-31)22-14-24(32)30-27(15-22)41(19(2)3)20(4)35-30/h1,8-9,14-16,19,23H,6-7,10-13,17-18H2,2-4H3,(H,34,36,37,38) IZSLXRORDBBGDE-UHFFFAOYSA-N 444556 US10662186, Compound 75::US10988476, Compound I-75 Cyclin-dependent kinase 6 Homo sapiens 5.16 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444556&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196859 440706801 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907026 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC#C)CCc3n2)ncc1F InChI=1S/C26H25F2N7/c1-5-9-34-10-8-21-17(14-34)6-7-23(31-21)32-26-29-13-20(28)24(33-26)18-11-19(27)25-22(12-18)35(15(2)3)16(4)30-25/h1,6-7,11-13,15H,8-10,14H2,2-4H3,(H,29,31,32,33) ZYONZFOMVOBYKS-UHFFFAOYSA-N 444557 US10662186, Compound 76::US10988476, Compound I-76 Cyclin-dependent kinase 6 Homo sapiens 4.58 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444557&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196677 440706802 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907029 C[C@@H](N)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-14(29)12-35-8-7-21-16(13-35)3-6-23(32-21)33-26-30-11-20(28)24(34-26)17-9-19(27)25-22(10-17)36(15(2)31-25)18-4-5-18/h3,6,9-11,14,18H,4-5,7-8,12-13,29H2,1-2H3,(H,30,32,33,34)/t14-/m1/s1 HWUQUQZRNDZMLC-CQSZACIVSA-N 444558 US10662186, Compound 77::US10988476, Compound I-77 Cyclin-dependent kinase 6 Homo sapiens 3.15 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444558&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196720 440706803 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907032 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CC(C)(C)N)CCc3n2)ncc1F InChI=1S/C27H30F2N8/c1-15-32-25-19(28)10-17(11-22(25)37(15)18-5-6-18)24-20(29)12-31-26(35-24)34-23-7-4-16-13-36(14-27(2,3)30)9-8-21(16)33-23/h4,7,10-12,18H,5-6,8-9,13-14,30H2,1-3H3,(H,31,33,34,35) RAIPOUVWZMOUJL-UHFFFAOYSA-N 444559 US10662186, Compound 78::US10988476, Compound I-78 Cyclin-dependent kinase 6 Homo sapiens 5.60 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444559&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196698 440706804 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907035 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC#CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H32F2N8/c1-18(2)39-19(3)33-28-22(30)14-21(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-20-17-38(13-10-24(20)34-26)12-7-6-11-37(4)5/h8-9,14-16,18H,10-13,17H2,1-5H3,(H,32,34,35,36) SUEYATVNHWMTSO-UHFFFAOYSA-N 444560 US10662186, Compound 79::US10988476, Compound I-79 Cyclin-dependent kinase 6 Homo sapiens 2.69 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444560&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196679 440706805 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907038 C[C@H](CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1)N(C)C InChI=1S/C28H32F2N8/c1-16(36(3)4)14-37-10-9-23-18(15-37)5-8-25(33-23)34-28-31-13-22(30)26(35-28)19-11-21(29)27-24(12-19)38(17(2)32-27)20-6-7-20/h5,8,11-13,16,20H,6-7,9-10,14-15H2,1-4H3,(H,31,33,34,35)/t16-/m1/s1 WIAMCDYCLOMHKF-MRXNPFEDSA-N 444561 US10662186, Compound 80::US10988476, Compound I-80 Cyclin-dependent kinase 6 Homo sapiens 3.67 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444561&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196724 440706806 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907041 C[C@H](N)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-14(29)12-35-8-7-21-16(13-35)3-6-23(32-21)33-26-30-11-20(28)24(34-26)17-9-19(27)25-22(10-17)36(15(2)31-25)18-4-5-18/h3,6,9-11,14,18H,4-5,7-8,12-13,29H2,1-2H3,(H,30,32,33,34)/t14-/m0/s1 HWUQUQZRNDZMLC-AWEZNQCLSA-N 444562 US10662186, Compound 81::US10988476, Compound I-81 Cyclin-dependent kinase 6 Homo sapiens 3.34 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444562&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196681 440706807 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907044 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H27F2N7/c1-4-17(5-2)34-14(3)30-24-18(26)10-16(11-21(24)34)23-19(27)13-29-25(33-23)32-22-7-6-15-12-28-9-8-20(15)31-22/h6-7,10-11,13,17,28H,4-5,8-9,12H2,1-3H3,(H,29,31,32,33) YPMOBRWHNOTUIL-UHFFFAOYSA-N 444563 US10662186, Compound 82::US10988476, Compound I-82 Cyclin-dependent kinase 6 Homo sapiens 3.16 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444563&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196672 440706808 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907047 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H36F2N8/c1-6-21(7-2)39-18(3)33-28-22(30)14-20(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(4)5)11-10-24(19)34-26/h8-9,14-16,21H,6-7,10-13,17H2,1-5H3,(H,32,34,35,36) POTKDJWRAMHALZ-UHFFFAOYSA-N 444564 US10662186, Compound 83::US10988476, Compound I-83 Cyclin-dependent kinase 6 Homo sapiens 1.55 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444564&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196685 440706809 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907050 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H25F2N7/c1-13(15-3-4-15)34-14(2)30-24-18(26)9-17(10-21(24)34)23-19(27)12-29-25(33-23)32-22-6-5-16-11-28-8-7-20(16)31-22/h5-6,9-10,12-13,15,28H,3-4,7-8,11H2,1-2H3,(H,29,31,32,33) ANELMUPUYRZVHZ-UHFFFAOYSA-N 444565 US10662186, Compound 84::US10988476, Compound I-84 Cyclin-dependent kinase 6 Homo sapiens 3.21 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444565&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196684 440706810 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907053 C[C@@H](CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1)N(C)C InChI=1S/C28H32F2N8/c1-16(36(3)4)14-37-10-9-23-18(15-37)5-8-25(33-23)34-28-31-13-22(30)26(35-28)19-11-21(29)27-24(12-19)38(17(2)32-27)20-6-7-20/h5,8,11-13,16,20H,6-7,9-10,14-15H2,1-4H3,(H,31,33,34,35)/t16-/m0/s1 WIAMCDYCLOMHKF-INIZCTEOSA-N 444566 US10662186, Compound 85::US10988476, Compound I-85 Cyclin-dependent kinase 6 Homo sapiens 2.54 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444566&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196687 440706811 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907056 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H34F2N8/c1-17(19-5-6-19)39-18(2)33-28-22(30)13-21(14-25(28)39)27-23(31)15-32-29(36-27)35-26-8-7-20-16-38(12-11-37(3)4)10-9-24(20)34-26/h7-8,13-15,17,19H,5-6,9-12,16H2,1-4H3,(H,32,34,35,36) VUKGJVXJRDQYFA-UHFFFAOYSA-N 444567 US10662186, Compound 86::US10988476, Compound I-86 Cyclin-dependent kinase 6 Homo sapiens 1.49 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444567&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196673 440706812 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907059 Cc1nc2c(F)cc(cc2n1C1(C)CC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H23F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2)6-7-24)21-17(26)12-28-23(32-21)31-20-4-3-14-11-27-8-5-18(14)30-20/h3-4,9-10,12,27H,5-8,11H2,1-2H3,(H,28,30,31,32) BONJLZFNDLMWRE-UHFFFAOYSA-N 444568 US10662186, Compound 87::US10988476, Compound I-87 Cyclin-dependent kinase 6 Homo sapiens 2.21 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444568&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196674 440706813 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907062 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2)8-9-28)25-21(30)15-31-27(35-25)34-24-6-5-18-16-37(12-11-36(3)4)10-7-22(18)33-24/h5-6,13-15H,7-12,16H2,1-4H3,(H,31,33,34,35) SPKWRLBKVPRPMT-UHFFFAOYSA-N 444569 US10662186, Compound 88::US10988476, Compound I-88 Cyclin-dependent kinase 6 Homo sapiens 1.41 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444569&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196688 440706814 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907065 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC[Si](C)(C)C)CCc3n2)ncc1F InChI=1S/C28H35F2N7Si/c1-17(2)37-18(3)32-27-21(29)13-20(14-24(27)37)26-22(30)15-31-28(35-26)34-25-8-7-19-16-36(10-9-23(19)33-25)11-12-38(4,5)6/h7-8,13-15,17H,9-12,16H2,1-6H3,(H,31,33,34,35) KZLNMNBKUXXLSY-UHFFFAOYSA-N 444570 US10662186, Compound 89::US10988476, Compound I-89 Cyclin-dependent kinase 6 Homo sapiens 17.9 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444570&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763674 440706815 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907068 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-9-8-19-17-38(12-7-11-37(5)6)13-10-23(19)34-25/h8-9,14-16H,7,10-13,17H2,1-6H3,(H,32,34,35,36) UVMVCEDKKHGTIW-UHFFFAOYSA-N 444571 US10662186, Compound 90::US10988476, Compound I-90 Cyclin-dependent kinase 6 Homo sapiens 1.56 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444571&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196721 440706816 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907071 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(N)=N)CCc3n2)ncc1F InChI=1S/C27H32F2N10/c1-15(2)39-16(3)33-25-19(28)11-18(12-22(25)39)24-20(29)13-32-27(36-24)35-23-6-5-17-14-38(8-7-21(17)34-23)10-9-37(4)26(30)31/h5-6,11-13,15H,7-10,14H2,1-4H3,(H3,30,31)(H,32,34,35,36) CEIAWFVLEUQXHI-UHFFFAOYSA-N 444572 US10662186, Compound 91::US10988476, Compound I-91 Cyclin-dependent kinase 6 Homo sapiens 1.70 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444572&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196686 440706817 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907074 CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H34F2N8O/c1-17-33-27-20(30)13-19(14-23(27)39(17)29(2,3)4)26-21(31)15-32-28(36-26)35-24-8-7-18-16-38(12-9-22(18)34-24)25(40)10-11-37(5)6/h7-8,13-15H,9-12,16H2,1-6H3,(H,32,34,35,36) AKDZNPFQMDRCMU-UHFFFAOYSA-N 444573 US10662186, Compound 92::US10988476, Compound I-92 Cyclin-dependent kinase 6 Homo sapiens 1.39 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444573&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196689 440706818 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907077 CN1CCO[C@@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m1/s1 PBDNNWWYSHCMCH-OAQYLSRUSA-N 444574 US10662186, Compound 93::US10988476, Compound I-93 Cyclin-dependent kinase 6 Homo sapiens 1.33 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444574&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196700 440706819 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907080 CN1CCO[C@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m0/s1 PBDNNWWYSHCMCH-NRFANRHFSA-N 444575 US10662186, Compound 94::US10988476, Compound I-94 Cyclin-dependent kinase 6 Homo sapiens 1.37 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444575&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196726 440706820 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907083 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C\C=N\O)CCc3n2)ncc1F InChI=1S/C25H26F2N8O/c1-14(2)35-15(3)30-24-18(26)10-17(11-21(24)35)23-19(27)12-28-25(33-23)32-22-5-4-16-13-34(9-7-29-36)8-6-20(16)31-22/h4-5,7,10-12,14,36H,6,8-9,13H2,1-3H3,(H,28,31,32,33)/b29-7+ XHCXEGJOAXJLFH-HBRQFSJYSA-N 444576 US10662186, Compound 95::US10988476, Compound I-95 Cyclin-dependent kinase 6 Homo sapiens 2.02 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444576&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196691 440706821 C02658 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907086 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN=C(N)N)CCc3n2)ncc1F InChI=1S/C26H30F2N10/c1-14(2)38-15(3)33-24-18(27)10-17(11-21(24)38)23-19(28)12-32-26(36-23)35-22-5-4-16-13-37(8-6-20(16)34-22)9-7-31-25(29)30/h4-5,10-12,14H,6-9,13H2,1-3H3,(H4,29,30,31)(H,32,34,35,36) FTFHCSWIOVPGGS-UHFFFAOYSA-N 444577 US10662186, Compound 97::US10988476, Compound I-98 Cyclin-dependent kinase 6 Homo sapiens 2.11 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444577&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196690 440706822 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907089 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1 InChI=1S/C29H34F2N8/c1-18-33-28-22(30)14-20(15-25(28)39(18)21-6-4-5-7-21)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(2)3)11-10-24(19)34-26/h8-9,14-16,21H,4-7,10-13,17H2,1-3H3,(H,32,34,35,36) CZQMPFCNIINMMC-UHFFFAOYSA-N 444578 US10662186, Compound 98 Cyclin-dependent kinase 6 Homo sapiens 5.01 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444578&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196675 440706823 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907092 C[C@@H]1NCCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C25H27F2N7/c1-13-16-6-7-21(31-19(16)8-9-28-13)32-24-29-12-18(27)22(33-24)15-10-17(26)23-20(11-15)34(14(2)30-23)25(3,4)5/h6-7,10-13,28H,8-9H2,1-5H3,(H,29,31,32,33)/t13-/m0/s1 YRUAMADPOZOPBF-ZDUSSCGKSA-N 444579 US10662186, Compound 101::US10662186, Compound 104 Cyclin-dependent kinase 6 Homo sapiens 2.90 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444579&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196693 440706824 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907095 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCCC5)c4c3)ccc2C1 InChI=1S/C30H36F2N8/c1-19-34-29-23(31)15-21(16-26(29)40(19)22-7-5-4-6-8-22)28-24(32)17-33-30(37-28)36-27-10-9-20-18-39(14-13-38(2)3)12-11-25(20)35-27/h9-10,15-17,22H,4-8,11-14,18H2,1-3H3,(H,33,35,36,37) BAPMZESGRJMZNL-UHFFFAOYSA-N 444580 US10662186, Compound 102::US10988476, Compound I-102 Cyclin-dependent kinase 6 Homo sapiens 2.41 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444580&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196692 440706825 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907098 C[C@@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1 QPSCTAMMABVQIH-KRWDZBQOSA-N 444581 US10662186, Compound 103::US10662186, Compound 106::US10988476, Compound I-106 Cyclin-dependent kinase 6 Homo sapiens 0.970 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444581&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196710 440706826 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907101 C[C@@H]1NCCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C25H27F2N7/c1-13-16-6-7-21(31-19(16)8-9-28-13)32-24-29-12-18(27)22(33-24)15-10-17(26)23-20(11-15)34(14(2)30-23)25(3,4)5/h6-7,10-13,28H,8-9H2,1-5H3,(H,29,31,32,33)/t13-/m0/s1 YRUAMADPOZOPBF-ZDUSSCGKSA-N 444579 US10662186, Compound 101::US10662186, Compound 104 Cyclin-dependent kinase 6 Homo sapiens 9.25 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444579&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196693 440706824 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907104 C[C@@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1 QPSCTAMMABVQIH-KRWDZBQOSA-N 444581 US10662186, Compound 103::US10662186, Compound 106::US10988476, Compound I-106 Cyclin-dependent kinase 6 Homo sapiens 2.67 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444581&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196710 440706826 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907107 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)P(C)(C)=O)CCc3n2)ncc1F InChI=1S/C28H35F2N8OP/c1-17(2)38-18(3)32-27-21(29)13-20(14-24(27)38)26-22(30)15-31-28(35-26)34-25-8-7-19-16-37(10-9-23(19)33-25)12-11-36(4)40(5,6)39/h7-8,13-15,17H,9-12,16H2,1-6H3,(H,31,33,34,35) YFRIHUMUDOXHTG-UHFFFAOYSA-N 444584 US10662186, Compound 107::US10988476, Compound I-107 Cyclin-dependent kinase 6 Homo sapiens 4.59 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444584&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196727 440706827 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907110 C[C@H]1CC[C@@H](CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C31H38F2N8/c1-19-5-8-23(9-6-19)41-20(2)35-30-24(32)15-22(16-27(30)41)29-25(33)17-34-31(38-29)37-28-10-7-21-18-40(14-13-39(3)4)12-11-26(21)36-28/h7,10,15-17,19,23H,5-6,8-9,11-14,18H2,1-4H3,(H,34,36,37,38)/t19-,23- IHSJJFRMGGAMME-UILWBTOOSA-N 444585 US10662186, Compound 108::US10988476, Compound I-108 Cyclin-dependent kinase 6 Homo sapiens 2.23 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444585&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196703 440706828 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907113 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 6 Homo sapiens 3.86 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907116 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(N)=S)CCc3n2)ncc1F InChI=1S/C27H31F2N9S/c1-15(2)38-16(3)32-25-19(28)11-18(12-22(25)38)24-20(29)13-31-27(35-24)34-23-6-5-17-14-37(8-7-21(17)33-23)10-9-36(4)26(30)39/h5-6,11-13,15H,7-10,14H2,1-4H3,(H2,30,39)(H,31,33,34,35) DKTHMZUTCUNQAZ-UHFFFAOYSA-N 444587 US10662186, Compound 110::US10988476, Compound I-110 Cyclin-dependent kinase 6 Homo sapiens 5.89 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444587&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196715 440706830 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 907119 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 6 Homo sapiens 2.98 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51271230 Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1 InChI=1S/C21H13Cl2N3O2S/c22-17-6-4-15(11-18(17)23)19(27)25-16-5-3-12-9-14(2-1-13(12)10-16)20(28)26-21-24-7-8-29-21/h1-11H,(H,25,27)(H,24,26,28) MRITYVDXXFOOAU-UHFFFAOYSA-N 50519158 CHEMBL4445812 Cyclin-dependent kinase 6 Homo sapiens 8020 ChEMBL 10.1021/acs.jmedchem.9b00353 10.7270/Q2X06BF7 31381325 Qi, B; Zhong, L; He, J; Zhang, H; Li, F; Wang, T; Zou, J; Lin, YX; Zhang, C; Guo, X; Li, R; Shi, J Chengdu University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519158&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 138911334 440727740 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51267919 CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1Cl)C(F)(F)F InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1 MRPGRAKIAJJGMM-OCCSQVGLSA-N 50193104 CHEMBL3905910 Cyclin-dependent kinase 6 Homo sapiens <100 ChEMBL 10.1016/j.bmc.2019.01.027 10.7270/Q2CF9TG4 30733087 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193104&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 67409219 375076114 CHEMBL3905910 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51267920 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(Cl)cccc1Cl)cc2=O InChI=1S/C23H21Cl2NO5/c1-26-8-7-14(20(30)11-26)21-18(28)10-19(29)22-17(27)9-12(31-23(21)22)5-6-13-15(24)3-2-4-16(13)25/h2-6,9-10,14,20,28-30H,7-8,11H2,1H3/b6-5+/t14-,20+/m0/s1 NFTJDXGFOUFNKG-UGBNQVSOSA-N 50263013 CHEMBL4079206 Cyclin-dependent kinase 6 Homo sapiens 45 ChEMBL 10.1016/j.bmc.2019.01.027 10.7270/Q2CF9TG4 30733087 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263013&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137628639 404341348 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51297394 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib Cyclin-dependent kinase 6 Homo sapiens 34000 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,7B5Q,7B5O 91844733 440735379 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51297408 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12 InChI=1S/C20H27N5O3/c1-13(2)15-10-22-25-19(21-9-14-6-4-3-5-7-14)8-18(24-20(15)25)23-16(11-26)17(28)12-27/h3-8,10,13,16-17,21,26-28H,9,11-12H2,1-2H3,(H,23,24)/t16-,17+/m0/s1 KRIWIRSMQRQYJG-DLBZAZTESA-N 50347388 CHEMBL1234833 Cyclin-dependent kinase 6 Homo sapiens 35500 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347388&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search NS9 3NS9 25125014 136354074 CHEMBL1234833 ZINC58655676 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51297415 CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27) DNYBIOICMDTDAP-UHFFFAOYSA-N 50347389 CHEMBL1801932 Cyclin-dependent kinase 6 Homo sapiens 47000 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347389&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 49867929 136354075 CHEMBL1801932 ZINC43207770 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51292324 CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(OC3CCCNC3)nc12 InChI=1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,10,13-14H2,1-2H3,(H,25,28,29) LSGRZENCFIIHNV-UHFFFAOYSA-N 50526793 CHEMBL4562323 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526793&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search WZ8 78161839 440735375 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51292332 CC(C)c1cnn2c(NCc3ccccc3N(C)C)nc(OC3CCN(C)CC3)nc12 InChI=1S/C23H33N7O/c1-16(2)19-15-25-30-21(19)26-23(31-18-10-12-29(5)13-11-18)27-22(30)24-14-17-8-6-7-9-20(17)28(3)4/h6-9,15-16,18H,10-14H2,1-5H3,(H,24,26,27) JYPAWUMVEPMZMD-UHFFFAOYSA-N 50526792 CHEMBL4454044 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526792&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 71731769 440735374 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51292357 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 6 Homo sapiens 80 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51292360 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 6 Homo sapiens 24500 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51292366 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@@H]3CCNC[C@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m0/s1 YCVGLKWJKIKVBI-PKOBYXMFSA-N 50526789 CHEMBL4459754 Cyclin-dependent kinase 6 Homo sapiens 32100 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526789&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search I73 5JQ8 137349544 440735371 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51333129 CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27) DNYBIOICMDTDAP-UHFFFAOYSA-N 50347389 CHEMBL1801932 Cyclin-dependent kinase 6 Homo sapiens 47000 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347389&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 49867929 136354075 CHEMBL1801932 ZINC43207770 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51333138 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib Cyclin-dependent kinase 6 Homo sapiens 34000 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,7B5Q,7B5O 91844733 440735379 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51333146 CC(C)c1cnn2c(NC3CCN(CC3)C(=O)O[C@H]3CCN(C3)C(=O)\C=C\CN(C)C)cc(C)nc12 InChI=1S/C26H39N7O3/c1-18(2)22-16-27-33-23(15-19(3)28-25(22)33)29-20-8-12-31(13-9-20)26(35)36-21-10-14-32(17-21)24(34)7-6-11-30(4)5/h6-7,15-16,18,20-21,29H,8-14,17H2,1-5H3/b7-6+/t21-/m0/s1 GRDAHPJRLCTJNA-BXKJMJEDSA-N 50539721 CHEMBL4635959 Cyclin-dependent kinase 6 Homo sapiens >8000 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539721&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 138608760 442141284 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51334298 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51334317 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Cyclin-dependent kinase 6 Homo sapiens 130 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51333927 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H31N5O3S2/c1-5-21(32)29-18-10-8-17(9-11-18)24(33)31-12-6-7-19(15-31)30-25-28-14-23(36-25)35-16-22-27-13-20(34-22)26(2,3)4/h5,8-11,13-14,19H,1,6-7,12,15-16H2,2-4H3,(H,28,30)(H,29,32)/t19-/m1/s1 COGUZYALRYMQTD-LJQANCHMSA-N 50539904 CHEMBL4647764 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01929 10.7270/Q25M698Z 32502343 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539904&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145749888 442141467 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028623 CN(C)CCN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C31H41F2N9/c1-20-35-29-23(32)16-22(17-26(29)42(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-9-8-21-19-41(11-10-25(21)36-27)15-14-40(7)13-12-39(5)6/h8-9,16-18H,10-15,19H2,1-7H3,(H,34,36,37,38) FHUULRWYKIDOHF-UHFFFAOYSA-N 444610 US10662186, Compound 158::US10988476, Compound I-158 Cyclin-dependent kinase 6 Homo sapiens 1.60 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444610&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196900 440706849 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028626 CN(CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1)CC[Si](C)(C)C InChI=1S/C32H44F2N8Si/c1-21-36-30-24(33)17-23(18-27(30)42(21)32(2,3)4)29-25(34)19-35-31(39-29)38-28-10-9-22-20-41(12-11-26(22)37-28)14-13-40(5)15-16-43(6,7)8/h9-10,17-19H,11-16,20H2,1-8H3,(H,35,37,38,39) VVVCNCSCTHVHSD-UHFFFAOYSA-N 444611 US10662186, Compound 160::US10988476, Compound I-160 Cyclin-dependent kinase 6 Homo sapiens 2.46 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444611&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763681 440706850 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028629 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCNC(C)=N)CCc3n2)ncc1F InChI=1S/C27H31F2N9/c1-15(2)38-17(4)33-26-20(28)11-19(12-23(26)38)25-21(29)13-32-27(36-25)35-24-6-5-18-14-37(9-7-22(18)34-24)10-8-31-16(3)30/h5-6,11-13,15H,7-10,14H2,1-4H3,(H2,30,31)(H,32,34,35,36) ZTXZICVBZWFLGQ-UHFFFAOYSA-N 444612 US10662186, Compound 175::US10988476, Compound I-175 Cyclin-dependent kinase 6 Homo sapiens 3.86 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444612&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196748 440706851 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028632 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C27H32F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2,3)4)24-20(29)14-31-26(35-24)34-23-7-6-17-15-36(11-9-30-5)10-8-21(17)33-23/h6-7,12-14,30H,8-11,15H2,1-5H3,(H,31,33,34,35) NCAQSQYHTSCOCV-UHFFFAOYSA-N 444613 US10662186, Compound 176::US10988476, Compound I-176 Cyclin-dependent kinase 6 Homo sapiens 1.51 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444613&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196747 440706852 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028635 CN(C)C(C)(C)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C30H38F2N8/c1-18-34-27-21(31)13-20(14-24(27)40(18)29(2,3)4)26-22(32)15-33-28(37-26)36-25-10-9-19-16-39(12-11-23(19)35-25)17-30(5,6)38(7)8/h9-10,13-15H,11-12,16-17H2,1-8H3,(H,33,35,36,37) QCCNJYPQBCTGGP-UHFFFAOYSA-N 444614 US10662186, Compound 192::US10988476, Compound I-192 Cyclin-dependent kinase 6 Homo sapiens 1.53 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444614&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196789 440706853 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028638 CCOP(=O)(OCC)C1(O)CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C34H45F2N8O4P/c1-7-47-49(46,48-8-2)34(45)12-14-43(21-34)16-15-42-13-11-27-23(20-42)9-10-29(39-27)40-32-37-19-26(36)30(41-32)24-17-25(35)31-28(18-24)44(22(3)38-31)33(4,5)6/h9-10,17-19,45H,7-8,11-16,20-21H2,1-6H3,(H,37,39,40,41) SESXHBRHIPVWPS-UHFFFAOYSA-N 444615 US10662186, Compound 196::US10988476, Compound I-196 Cyclin-dependent kinase 6 Homo sapiens 2.99 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444615&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196756 440706854 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028641 CN(CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1)CCP(O)(O)=O InChI=1S/C29H37F2N8O3P/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-7-6-19-17-38(9-8-23(19)34-25)11-10-37(5)12-13-43(40,41)42/h6-7,14-16H,8-13,17H2,1-5H3,(H2,40,41,42)(H,32,34,35,36) VSZKYBBLLRBZLS-UHFFFAOYSA-N 444616 US10662186, Compound 197::US10988476, Compound I-197 Cyclin-dependent kinase 6 Homo sapiens 12.9 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444616&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196803 440706855 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028644 CCOP(=O)(CCN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1)OCC InChI=1S/C33H45F2N8O3P/c1-8-45-47(44,46-9-2)17-16-41(7)14-15-42-13-12-27-23(21-42)10-11-29(38-27)39-32-36-20-26(35)30(40-32)24-18-25(34)31-28(19-24)43(22(3)37-31)33(4,5)6/h10-11,18-20H,8-9,12-17,21H2,1-7H3,(H,36,38,39,40) AWZRGPIFBNJODY-UHFFFAOYSA-N 444617 US10662186, Compound 198::US10988476, Compound I-198 Cyclin-dependent kinase 6 Homo sapiens 2.03 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444617&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196760 440706856 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028647 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CC(N)=NO)CCc3n2)ncc1F InChI=1S/C26H29F2N9O/c1-14-31-24-17(27)9-16(10-20(24)37(14)26(2,3)4)23-18(28)11-30-25(34-23)33-22-6-5-15-12-36(13-21(29)35-38)8-7-19(15)32-22/h5-6,9-11,38H,7-8,12-13H2,1-4H3,(H2,29,35)(H,30,32,33,34) GCELNWHYDYQJHB-UHFFFAOYSA-N 444618 US10662186, Compound 199::US10988476, Compound I-199 Cyclin-dependent kinase 6 Homo sapiens 2.31 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444618&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763683 440706857 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028650 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(\C)=N/O)CCc3n2)ncc1F InChI=1S/C28H33F2N9O/c1-16(2)39-17(3)32-27-21(29)12-20(13-24(27)39)26-22(30)14-31-28(35-26)34-25-7-6-19-15-38(9-8-23(19)33-25)11-10-37(5)18(4)36-40/h6-7,12-14,16,40H,8-11,15H2,1-5H3,(H,31,33,34,35)/b36-18- HCAPKVUYVLOOHA-VHFSBPNMSA-N 494016 US10988476, Compound I-200::US10988476, Compound I-97 Cyclin-dependent kinase 6 Homo sapiens 5.89 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494016&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196702 447112540 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028653 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN)CCc3n2)ncc1F InChI=1S/C26H30F2N8/c1-15-31-24-18(27)11-17(12-21(24)36(15)26(2,3)4)23-19(28)13-30-25(34-23)33-22-6-5-16-14-35(10-8-29)9-7-20(16)32-22/h5-6,11-13H,7-10,14,29H2,1-4H3,(H,30,32,33,34) IWSDTEGBQVXXON-UHFFFAOYSA-N 444620 US10662186, Compound 202::US10988476, Compound I-202 Cyclin-dependent kinase 6 Homo sapiens 1.11 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444620&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196757 440706859 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028656 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2)7-8-27)24-20(29)14-31-26(35-24)34-23-5-4-17-15-36(11-9-30-3)10-6-21(17)33-23/h4-5,12-14,30H,6-11,15H2,1-3H3,(H,31,33,34,35) SAKHMWHBWMDUMO-UHFFFAOYSA-N 444621 US10662186, Compound 203::US10988476, Compound I-203 Cyclin-dependent kinase 6 Homo sapiens 1.28 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444621&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196758 440706860 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028659 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCN(C)(C)=O)CCc3n2)ncc1F InChI=1S/C27H30F2N8O/c1-16-31-26-20(28)12-18(13-23(26)36(16)19-5-6-19)25-21(29)14-30-27(34-25)33-24-7-4-17-15-35(9-8-22(17)32-24)10-11-37(2,3)38/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,30,32,33,34) AAYWXOINDKYXKL-UHFFFAOYSA-N 494061 US10988476, Compound I-204 Cyclin-dependent kinase 6 Homo sapiens 25.7 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494061&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 154612571 447112582 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028662 CCOP(=O)(OCC)N(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C30H39F2N8O3P/c1-7-42-44(41,43-8-2)38(6)13-14-39-12-11-25-21(18-39)9-10-27(35-25)36-30-33-17-24(32)28(37-30)22-15-23(31)29-26(16-22)40(19(3)4)20(5)34-29/h9-10,15-17,19H,7-8,11-14,18H2,1-6H3,(H,33,35,36,37) SAIXTBXXQWMWMW-UHFFFAOYSA-N 50502338 CHEMBL4525034::US10988476, Compound I-205 Cyclin-dependent kinase 6 Homo sapiens 14.7 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502338&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196784 440710923 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028665 CC(CN(C)C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8/c1-17(15-37(6)7)38-11-10-23-19(16-38)8-9-25(34-23)35-28-32-14-22(31)26(36-28)20-12-21(30)27-24(13-20)39(18(2)33-27)29(3,4)5/h8-9,12-14,17H,10-11,15-16H2,1-7H3,(H,32,34,35,36) MDLZFWHQTJGZMT-UHFFFAOYSA-N 444624 US10662186, Compound 206::US10988476, Compound I-206 Cyclin-dependent kinase 6 Homo sapiens 1.76 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444624&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196762 440706863 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028668 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCC(=CC4)B(O)O)CCc3n2)ncc1F InChI=1S/C31H37BF2N8O2/c1-19-36-29-23(33)15-21(16-26(29)42(19)31(2,3)4)28-24(34)17-35-30(39-28)38-27-6-5-20-18-41(12-9-25(20)37-27)14-13-40-10-7-22(8-11-40)32(43)44/h5-7,15-17,43-44H,8-14,18H2,1-4H3,(H,35,37,38,39) ZSNPHFWSNIDXSN-UHFFFAOYSA-N 444625 US10662186, Compound 207::US10988476, Compound I-207 Cyclin-dependent kinase 6 Homo sapiens 1.73 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444625&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763678 440706864 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028671 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCS(C)(=O)=O)CCc3n2)ncc1F InChI=1S/C27H31F2N7O2S/c1-16-31-25-19(28)12-18(13-22(25)36(16)27(2,3)4)24-20(29)14-30-26(34-24)33-23-7-6-17-15-35(9-8-21(17)32-23)10-11-39(5,37)38/h6-7,12-14H,8-11,15H2,1-5H3,(H,30,32,33,34) SDAWBLGFXWXOCC-UHFFFAOYSA-N 444626 US10662186, Compound 208::US10988476, Compound I-208 Cyclin-dependent kinase 6 Homo sapiens 2.58 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444626&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196761 440706865 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028674 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC=NO)CCc3n2)ncc1F InChI=1S/C25H26F2N8O/c1-14(2)35-15(3)30-24-18(26)10-17(11-21(24)35)23-19(27)12-28-25(33-23)32-22-5-4-16-13-34(9-7-29-36)8-6-20(16)31-22/h4-5,7,10-12,14,36H,6,8-9,13H2,1-3H3,(H,28,31,32,33)/b29-7+ XHCXEGJOAXJLFH-HBRQFSJYSA-N 494066 US10988476, Compound I-209 Cyclin-dependent kinase 6 Homo sapiens 2.39 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494066&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 141707303 447112587 C02658 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028677 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CC(C)(C)N)CCc3n2)ncc1F InChI=1S/C28H34F2N8/c1-16-33-25-19(29)11-18(12-22(25)38(16)27(2,3)4)24-20(30)13-32-26(36-24)35-23-8-7-17-14-37(15-28(5,6)31)10-9-21(17)34-23/h7-8,11-13H,9-10,14-15,31H2,1-6H3,(H,32,34,35,36) POVBNEVJRAXZQO-UHFFFAOYSA-N 444628 US10662186, Compound 210::US10988476, Compound I-210 Cyclin-dependent kinase 6 Homo sapiens 1.80 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444628&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196755 440706867 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028680 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCC(CC4)B(O)O)CCc3n2)ncc1F InChI=1S/C31H39BF2N8O2/c1-19-36-29-23(33)15-21(16-26(29)42(19)31(2,3)4)28-24(34)17-35-30(39-28)38-27-6-5-20-18-41(12-9-25(20)37-27)14-13-40-10-7-22(8-11-40)32(43)44/h5-6,15-17,22,43-44H,7-14,18H2,1-4H3,(H,35,37,38,39) IRHOQMGOYMQRJB-UHFFFAOYSA-N 444629 US10662186, Compound 211::US10988476, Compound I-211 Cyclin-dependent kinase 6 Homo sapiens 1.36 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444629&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763677 440706868 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028683 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H23F2N7/c1-12(2)32-13(3)28-22-16(24)8-15(9-19(22)32)21-17(25)11-27-23(31-21)30-20-5-4-14-10-26-7-6-18(14)29-20/h4-5,8-9,11-12,26H,6-7,10H2,1-3H3,(H,27,29,30,31) HFKMNAUFISJBSK-UHFFFAOYSA-N 444486 US10662186, Compound 13::US10662186, Compound comparative A::US10988476, comparative example A Cyclin-dependent kinase 6 Homo sapiens 13.2 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444486&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118693642 440706734 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028686 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CO)ncc1F InChI=1S/C25H25F2N7O2/c1-13(2)34-14(3)29-24-17(26)8-16(9-20(24)34)23-18(27)10-28-25(32-23)31-21-5-4-15-11-33(22(36)12-35)7-6-19(15)30-21/h4-5,8-10,13,35H,6-7,11-12H2,1-3H3,(H,28,30,31,32) HLOKDQHOCMHLLI-UHFFFAOYSA-N 50458035 CHEMBL4213219::US10662186, Compound comparative B::US10988476, comparative example B Cyclin-dependent kinase 6 Homo sapiens 7.58 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458035&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118700794 433925300 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028689 COCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H29F2N7O/c1-15(2)35-16(3)30-25-19(27)11-18(12-22(25)35)24-20(28)13-29-26(33-24)32-23-6-5-17-14-34(9-10-36-4)8-7-21(17)31-23/h5-6,11-13,15H,7-10,14H2,1-4H3,(H,29,31,32,33) ROMAHJZEHBXJSU-UHFFFAOYSA-N 50458046 CHEMBL4213756::US10662186, Compound comparative C::US10988476, comparative example C Cyclin-dependent kinase 6 Homo sapiens 7.26 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458046&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118693641 433925311 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028692 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(C)=O)ncc1F InChI=1S/C25H25F2N7O/c1-13(2)34-14(3)29-24-18(26)9-17(10-21(24)34)23-19(27)11-28-25(32-23)31-22-6-5-16-12-33(15(4)35)8-7-20(16)30-22/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,28,30,31,32) AZENZYQBDCPVQO-UHFFFAOYSA-N 444633 US10662186, Compound comparative D::US10988476, comparative example D Cyclin-dependent kinase 6 Homo sapiens 7.22 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444633&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118700840 440706871 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028695 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCO)CCc3n2)ncc1F InChI=1S/C25H27F2N7O/c1-14(2)34-15(3)29-24-18(26)10-17(11-21(24)34)23-19(27)12-28-25(32-23)31-22-5-4-16-13-33(8-9-35)7-6-20(16)30-22/h4-5,10-12,14,35H,6-9,13H2,1-3H3,(H,28,30,31,32) ZAPGHPQYYDYEQW-UHFFFAOYSA-N 444634 US10662186, Compound comparative E::US10988476, comparative example E Cyclin-dependent kinase 6 Homo sapiens 9.17 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444634&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118693648 440706872 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028698 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCF)CCc3n2)ncc1F InChI=1S/C25H26F3N7/c1-14(2)35-15(3)30-24-18(27)10-17(11-21(24)35)23-19(28)12-29-25(33-23)32-22-5-4-16-13-34(9-7-26)8-6-20(16)31-22/h4-5,10-12,14H,6-9,13H2,1-3H3,(H,29,31,32,33) GZAGBRPFBCDRDL-UHFFFAOYSA-N 50458036 CHEMBL4207796::US10662186, Compound comparative F::US10988476, comparative example F Cyclin-dependent kinase 6 Homo sapiens 2.67 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458036&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 118700782 433925301 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028257 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 11.7 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028260 CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H29F2N7/c1-14(2)34-9-8-21-17(13-34)6-7-23(31-21)32-26-29-12-20(28)24(33-26)18-10-19(27)25-22(11-18)35(15(3)4)16(5)30-25/h6-7,10-12,14-15H,8-9,13H2,1-5H3,(H,29,31,32,33) XIVVCWMLPOQNDX-UHFFFAOYSA-N 444478 US10662186, Compound 3::US10988476, Compound I-3 Cyclin-dependent kinase 6 Homo sapiens 10.4 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444478&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196669 440706727 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028263 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H28F2N8O/c1-14(2)36-15(3)31-25-18(27)9-17(10-21(25)36)24-19(28)11-30-26(34-24)33-22-6-5-16-13-35(23(37)12-29-4)8-7-20(16)32-22/h5-6,9-11,14,29H,7-8,12-13H2,1-4H3,(H,30,32,33,34) DYNVDYWVVYCHHR-UHFFFAOYSA-N 444479 US10662186, Compound 4::US10662186, Compound 6::US10988476, Compound I-4 Cyclin-dependent kinase 6 Homo sapiens 3.49 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444479&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196660 440706728 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028266 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN(C)C)ncc1F InChI=1S/C27H30F2N8O/c1-15(2)37-16(3)31-26-19(28)10-18(11-22(26)37)25-20(29)12-30-27(34-25)33-23-7-6-17-13-36(9-8-21(17)32-23)24(38)14-35(4)5/h6-7,10-12,15H,8-9,13-14H2,1-5H3,(H,30,32,33,34) SSVSKCKWUAPYHI-UHFFFAOYSA-N 50458034 CHEMBL4212532::US10662186, Compound 5::US10988476, Compound I-5 Cyclin-dependent kinase 6 Homo sapiens 4.14 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458034&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114516 433925299 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028269 COCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H27F2N7O2/c1-14(2)35-15(3)30-25-18(27)9-17(10-21(25)35)24-19(28)11-29-26(33-24)32-22-6-5-16-12-34(23(36)13-37-4)8-7-20(16)31-22/h5-6,9-11,14H,7-8,12-13H2,1-4H3,(H,29,31,32,33) ZAFJPCZWYDCVJT-UHFFFAOYSA-N 493933 US10988476, Compound I-6 Cyclin-dependent kinase 6 Homo sapiens 7.57 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493933&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114312 447112457 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028272 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C)CCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13(2)33-14(3)28-23-17(25)9-16(10-20(23)33)22-18(26)11-27-24(31-22)30-21-6-5-15-12-32(4)8-7-19(15)29-21/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,27,29,30,31) AXTGGTFVALFVDO-UHFFFAOYSA-N 444482 US10662186, Compound 8::US10988476, Compound I-8 Cyclin-dependent kinase 6 Homo sapiens 7.07 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444482&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196664 440706730 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028275 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CCO)ncc1F InChI=1S/C26H27F2N7O2/c1-14(2)35-15(3)30-25-18(27)10-17(11-21(25)35)24-19(28)12-29-26(33-24)32-22-5-4-16-13-34(23(37)7-9-36)8-6-20(16)31-22/h4-5,10-12,14,36H,6-9,13H2,1-3H3,(H,29,31,32,33) JDIAYVMOUUKPNK-UHFFFAOYSA-N 444483 US10662186, Compound 9::US10988476, Compound I-9 Cyclin-dependent kinase 6 Homo sapiens 7.09 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444483&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196659 440706731 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028278 COC(=O)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H25F2N7O3/c1-13(2)35-14(3)30-23-17(27)9-16(10-20(23)35)22-18(28)11-29-26(33-22)32-21-6-5-15-12-34(8-7-19(15)31-21)24(36)25(37)38-4/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,29,31,32,33) HVTYFANOGPVRAE-UHFFFAOYSA-N 444484 US10662186, Compound 10::US10988476, Compound I-10 Cyclin-dependent kinase 6 Homo sapiens 7.81 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444484&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196670 440706732 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028281 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC(F)(F)F)CCc3n2)ncc1F InChI=1S/C25H24F5N7/c1-13(2)37-14(3)32-23-17(26)8-16(9-20(23)37)22-18(27)10-31-24(35-22)34-21-5-4-15-11-36(12-25(28,29)30)7-6-19(15)33-21/h4-5,8-10,13H,6-7,11-12H2,1-3H3,(H,31,33,34,35) XFNINEDWLFKZMH-UHFFFAOYSA-N 444485 US10662186, Compound 12::US10988476, Compound I-12 Cyclin-dependent kinase 6 Homo sapiens 14.2 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444485&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114456 440706733 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028284 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ncc3CNCCc3n2)ncc1F InChI=1S/C22H22F2N8/c1-11(2)32-12(3)28-20-15(23)6-13(7-18(20)32)19-16(24)10-27-22(30-19)31-21-26-9-14-8-25-5-4-17(14)29-21/h6-7,9-11,25H,4-5,8H2,1-3H3,(H,26,27,29,30,31) GUPLVXQEYAKBCK-UHFFFAOYSA-N 493938 US10988476, Compound I-13 Cyclin-dependent kinase 6 Homo sapiens 327 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493938&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114460 447112462 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028287 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ncc3CN(CCc3n2)C(=O)CN(C)C)ncc1F InChI=1S/C26H29F2N9O/c1-14(2)37-15(3)31-24-18(27)8-16(9-21(24)37)23-19(28)11-30-26(33-23)34-25-29-10-17-12-36(7-6-20(17)32-25)22(38)13-35(4)5/h8-11,14H,6-7,12-13H2,1-5H3,(H,29,30,32,33,34) BAFFTSARAOAHFW-UHFFFAOYSA-N 493939 US10988476, Compound I-14 Cyclin-dependent kinase 6 Homo sapiens 140 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493939&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196662 447112463 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028290 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3C(=O)N(CCN(C)C)Cc3n2)ncc1F InChI=1S/C26H28F2N8O/c1-14(2)36-15(3)30-24-18(27)10-16(11-21(24)36)23-19(28)12-29-26(33-23)32-22-7-6-17-20(31-22)13-35(25(17)37)9-8-34(4)5/h6-7,10-12,14H,8-9,13H2,1-5H3,(H,29,31,32,33) UNSAZGGWYRHTHJ-UHFFFAOYSA-N 444488 US10662186, Compound 15::US10988476, Compound I-15 Cyclin-dependent kinase 6 Homo sapiens 113 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444488&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196668 440706736 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028293 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN)ncc1F InChI=1S/C25H26F2N8O/c1-13(2)35-14(3)30-24-17(26)8-16(9-20(24)35)23-18(27)11-29-25(33-23)32-21-5-4-15-12-34(22(36)10-28)7-6-19(15)31-21/h4-5,8-9,11,13H,6-7,10,12,28H2,1-3H3,(H,29,31,32,33) AWSGLYKKQMTOCZ-UHFFFAOYSA-N 493941 US10988476, Compound I-17 Cyclin-dependent kinase 6 Homo sapiens 4.88 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493941&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196661 447112465 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028296 COC(=O)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H27F2N7O2/c1-14(2)35-15(3)30-25-18(27)9-17(10-21(25)35)24-19(28)11-29-26(33-24)32-22-6-5-16-12-34(13-23(36)37-4)8-7-20(16)31-22/h5-6,9-11,14H,7-8,12-13H2,1-4H3,(H,29,31,32,33) WEIJWGUXTMLFKT-UHFFFAOYSA-N 493942 US10988476, Compound I-19 Cyclin-dependent kinase 6 Homo sapiens 12.4 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493942&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196665 447112466 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028299 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC(O)=O)CCc3n2)ncc1F InChI=1S/C25H25F2N7O2/c1-13(2)34-14(3)29-24-17(26)8-16(9-20(24)34)23-18(27)10-28-25(32-23)31-21-5-4-15-11-33(12-22(35)36)7-6-19(15)30-21/h4-5,8-10,13H,6-7,11-12H2,1-3H3,(H,35,36)(H,28,30,31,32) VLWZGXZKJHXLTL-UHFFFAOYSA-N 493943 US10988476, Compound I-20 Cyclin-dependent kinase 6 Homo sapiens 22.3 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493943&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124113999 447112467 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028302 Cc1nc2c(F)cc(cc2n1C1CCCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H25F2N7/c1-14-30-24-18(26)10-16(11-21(24)34(14)17-4-2-3-5-17)23-19(27)13-29-25(33-23)32-22-7-6-15-12-28-9-8-20(15)31-22/h6-7,10-11,13,17,28H,2-5,8-9,12H2,1H3,(H,29,31,32,33) WCEJWHANTHYYCV-UHFFFAOYSA-N 444492 US10662186, Compound 21::US10988476, Compound I-21 Cyclin-dependent kinase 6 Homo sapiens 25.0 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444492&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114422 440706740 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028305 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-17-33-28-21(30)12-19(13-24(28)39(17)20-6-4-5-7-20)27-22(31)14-32-29(36-27)35-25-9-8-18-15-38(11-10-23(18)34-25)26(40)16-37(2)3/h8-9,12-14,20H,4-7,10-11,15-16H2,1-3H3,(H,32,34,35,36) ZFXSUJXETQKSKI-UHFFFAOYSA-N 444493 US10662186, Compound 22::US10988476, Compound I-22 Cyclin-dependent kinase 6 Homo sapiens 10.6 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444493&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196666 440706741 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028308 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCN(C)CC2)ncc1F InChI=1S/C30H35F2N9O/c1-18(2)41-19(3)34-29-22(31)13-21(14-25(29)41)28-23(32)15-33-30(37-28)36-26-6-5-20-16-40(8-7-24(20)35-26)27(42)17-39-11-9-38(4)10-12-39/h5-6,13-15,18H,7-12,16-17H2,1-4H3,(H,33,35,36,37) KZZDDXBCJROTIP-UHFFFAOYSA-N 50458051 CHEMBL4206061::US10988476, Compound I-23 Cyclin-dependent kinase 6 Homo sapiens 4.17 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458051&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114324 433925316 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028311 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCOCC2)ncc1F InChI=1S/C29H32F2N8O2/c1-17(2)39-18(3)33-28-21(30)12-20(13-24(28)39)27-22(31)14-32-29(36-27)35-25-5-4-19-15-38(7-6-23(19)34-25)26(40)16-37-8-10-41-11-9-37/h4-5,12-14,17H,6-11,15-16H2,1-3H3,(H,32,34,35,36) HXKORJQOSCRLJP-UHFFFAOYSA-N 444495 US10662186, Compound 24::US10988476, Compound I-24 Cyclin-dependent kinase 6 Homo sapiens 6.44 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444495&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114319 440706743 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028314 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C(C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35) SSIOYGMEKCPFAV-UHFFFAOYSA-N 444496 US10662186, Compound 25::US10988476, Compound I-25 Cyclin-dependent kinase 6 Homo sapiens 5.78 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444496&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196667 440706744 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028317 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CC(C)(C)O)ncc1F InChI=1S/C28H31F2N7O2/c1-15(2)37-16(3)32-26-19(29)10-18(11-22(26)37)25-20(30)13-31-27(35-25)34-23-7-6-17-14-36(9-8-21(17)33-23)24(38)12-28(4,5)39/h6-7,10-11,13,15,39H,8-9,12,14H2,1-5H3,(H,31,33,34,35) DHMHGKLKKIGMHX-UHFFFAOYSA-N 444498 US10662186, Compound 26::US10988476, Compound I-26 Cyclin-dependent kinase 6 Homo sapiens 8.12 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444498&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196671 440706746 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028320 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C(C)(C)N(C)C)ncc1F InChI=1S/C29H34F2N8O/c1-16(2)39-17(3)33-26-20(30)12-19(13-23(26)39)25-21(31)14-32-28(36-25)35-24-9-8-18-15-38(11-10-22(18)34-24)27(40)29(4,5)37(6)7/h8-9,12-14,16H,10-11,15H2,1-7H3,(H,32,34,35,36) DNFNQGHGGVBVSY-UHFFFAOYSA-N 444499 US10662186, Compound 27::US10988476, Compound I-27 Cyclin-dependent kinase 6 Homo sapiens 14.1 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444499&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196846 440706747 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028323 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H21F2N7/c1-12-28-22-16(24)8-14(9-19(22)32(12)15-3-4-15)21-17(25)11-27-23(31-21)30-20-5-2-13-10-26-7-6-18(13)29-20/h2,5,8-9,11,15,26H,3-4,6-7,10H2,1H3,(H,27,29,30,31) GJEWTVQXBHSVAU-UHFFFAOYSA-N 444500 US10662186, Compound 28::US10988476, Compound I-28 Cyclin-dependent kinase 6 Homo sapiens 18.9 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444500&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196743 440706748 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028326 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-31-26-19(28)10-17(11-22(26)37(15)18-5-6-18)25-20(29)12-30-27(34-25)33-23-7-4-16-13-36(9-8-21(16)32-23)24(38)14-35(2)3/h4,7,10-12,18H,5-6,8-9,13-14H2,1-3H3,(H,30,32,33,34) OIQZLVBXHSEFQP-UHFFFAOYSA-N 444501 US10662186, Compound 29::US10662186, Compound 37::US10662186, Compound 64::US10988476, Compound I-29 Cyclin-dependent kinase 6 Homo sapiens 4.98 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444501&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196847 440706749 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028329 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCOCC2)ncc1F InChI=1S/C29H30F2N8O2/c1-17-33-28-21(30)12-19(13-24(28)39(17)20-3-4-20)27-22(31)14-32-29(36-27)35-25-5-2-18-15-38(7-6-23(18)34-25)26(40)16-37-8-10-41-11-9-37/h2,5,12-14,20H,3-4,6-11,15-16H2,1H3,(H,32,34,35,36) QHCHMOFMVBOPSK-UHFFFAOYSA-N 493953 US10988476, Compound I-30 Cyclin-dependent kinase 6 Homo sapiens 3.38 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493953&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196841 447112477 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028332 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CC(O)C2)ncc1F InChI=1S/C28H29F2N7O2/c1-14(2)37-15(3)32-26-20(29)10-17(11-23(26)37)25-21(30)12-31-28(35-25)34-24-5-4-16-13-36(7-6-22(16)33-24)27(39)18-8-19(38)9-18/h4-5,10-12,14,18-19,38H,6-9,13H2,1-3H3,(H,31,33,34,35) AVKHUGZDSUKIKQ-UHFFFAOYSA-N 493954 US10988476, Compound I-31 Cyclin-dependent kinase 6 Homo sapiens 4.84 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493954&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196848 447112478 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028335 Cc1nc2c(F)cc(cc2n1C1CCCCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C26H27F2N7/c1-15-31-25-19(27)11-17(12-22(25)35(15)18-5-3-2-4-6-18)24-20(28)14-30-26(34-24)33-23-8-7-16-13-29-10-9-21(16)32-23/h7-8,11-12,14,18,29H,2-6,9-10,13H2,1H3,(H,30,32,33,34) UJHKKNOWOJMKCR-UHFFFAOYSA-N 444504 US10662186, Compound 32::US10988476, Compound I-32 Cyclin-dependent kinase 6 Homo sapiens 13.2 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444504&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196738 440706752 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028338 C[C@H]1CCC(CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C27H29F2N7/c1-15-3-6-19(7-4-15)36-16(2)32-26-20(28)11-18(12-23(26)36)25-21(29)14-31-27(35-25)34-24-8-5-17-13-30-10-9-22(17)33-24/h5,8,11-12,14-15,19,30H,3-4,6-7,9-10,13H2,1-2H3,(H,31,33,34,35)/t15-,19? JAZHDXRHOSJZHB-XIRXVJAISA-N 444505 US10662186, Compound 33::US10988476, Compound I-33 Cyclin-dependent kinase 6 Homo sapiens 6.23 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444505&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196845 440706753 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028341 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC[C@H](C)CC5)c4c3)ccc2C1 InChI=1S/C30H34F2N8O/c1-17-4-7-21(8-5-17)40-18(2)35-29-22(31)12-20(13-25(29)40)28-23(32)14-34-30(38-28)37-26-9-6-19-16-39(27(41)15-33-3)11-10-24(19)36-26/h6,9,12-14,17,21,33H,4-5,7-8,10-11,15-16H2,1-3H3,(H,34,36,37,38)/t17-,21? CVNQRFZZFGTWIK-KJPGQXGLSA-N 444507 US10662186, Compound 34::US10988476, Compound I-34 Cyclin-dependent kinase 6 Homo sapiens 2.56 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444507&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196844 440706755 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028344 C[C@H]1CCC(CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN(C)C)ncc1F InChI=1S/C31H36F2N8O/c1-18-5-8-22(9-6-18)41-19(2)35-30-23(32)13-21(14-26(30)41)29-24(33)15-34-31(38-29)37-27-10-7-20-16-40(12-11-25(20)36-27)28(42)17-39(3)4/h7,10,13-15,18,22H,5-6,8-9,11-12,16-17H2,1-4H3,(H,34,36,37,38)/t18-,22? YERVFCNDCWMBBO-ZKCBWYJKSA-N 444510 US10662186, Compound 35::US10988476, Compound I-35 Cyclin-dependent kinase 6 Homo sapiens 4.53 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444510&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196839 440706758 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028347 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCCC5)c4c3)ccc2C1 InChI=1S/C30H34F2N8O/c1-18-34-29-22(31)13-20(14-25(29)40(18)21-7-5-4-6-8-21)28-23(32)15-33-30(37-28)36-26-10-9-19-16-39(12-11-24(19)35-26)27(41)17-38(2)3/h9-10,13-15,21H,4-8,11-12,16-17H2,1-3H3,(H,33,35,36,37) HCCNJLKJQAHREN-UHFFFAOYSA-N 444512 US10662186, Compound 36::US10988476, Compound I-36 Cyclin-dependent kinase 6 Homo sapiens 7.41 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444512&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196843 440706760 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028350 CN(C)C(=O)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-31-26-19(28)10-17(11-22(26)37(15)18-5-6-18)25-20(29)12-30-27(34-25)33-23-7-4-16-13-36(9-8-21(16)32-23)14-24(38)35(2)3/h4,7,10-12,18H,5-6,8-9,13-14H2,1-3H3,(H,30,32,33,34) VFUTVVZNBWJHDY-UHFFFAOYSA-N 493960 US10988476, Compound I-37 Cyclin-dependent kinase 6 Homo sapiens 16.1 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493960&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196840 447112484 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028353 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C=C)ncc1F InChI=1S/C26H25F2N7O/c1-5-23(36)34-9-8-20-16(13-34)6-7-22(31-20)32-26-29-12-19(28)24(33-26)17-10-18(27)25-21(11-17)35(14(2)3)15(4)30-25/h5-7,10-12,14H,1,8-9,13H2,2-4H3,(H,29,31,32,33) SOHOEERULHWXJB-UHFFFAOYSA-N 444516 US10662186, Compound 38::US10988476, Compound I-38 Cyclin-dependent kinase 6 Homo sapiens 4.37 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444516&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114603 440706763 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028356 Cc1nc2c(F)cc(cc2n1C1CCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H23F2N7/c1-13-29-23-17(25)9-15(10-20(23)33(13)16-3-2-4-16)22-18(26)12-28-24(32-22)31-21-6-5-14-11-27-8-7-19(14)30-21/h5-6,9-10,12,16,27H,2-4,7-8,11H2,1H3,(H,28,30,31,32) SVXDTIUTCGVODS-UHFFFAOYSA-N 444518 US10662186, Compound 39::US10988476, Compound I-39 Cyclin-dependent kinase 6 Homo sapiens 7.43 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444518&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124114305 440706765 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028359 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CC(N)C2)ncc1F InChI=1S/C28H30F2N8O/c1-14(2)38-15(3)33-26-20(29)10-17(11-23(26)38)25-21(30)12-32-28(36-25)35-24-5-4-16-13-37(7-6-22(16)34-24)27(39)18-8-19(31)9-18/h4-5,10-12,14,18-19H,6-9,13,31H2,1-3H3,(H,32,34,35,36) MZGANASDMYZAGW-UHFFFAOYSA-N 444519 US10662186, Compound 40::US10988476, Compound I-40 Cyclin-dependent kinase 6 Homo sapiens 3.59 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444519&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196822 440706766 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028362 CC(C)n1c(C)nc2c(cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F)C(F)(F)F InChI=1S/C24H23F4N7/c1-12(2)35-13(3)31-22-16(24(26,27)28)8-15(9-19(22)35)21-17(25)11-30-23(34-21)33-20-5-4-14-10-29-7-6-18(14)32-20/h4-5,8-9,11-12,29H,6-7,10H2,1-3H3,(H,30,32,33,34) IYUGPEZCKNVRDO-UHFFFAOYSA-N 444520 US10662186, Compound 41::US10988476, Compound I-41 Cyclin-dependent kinase 6 Homo sapiens 272 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444520&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763691 440706767 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028365 CNC1CC(C1)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-15(2)39-16(3)34-27-21(30)11-18(12-24(27)39)26-22(31)13-33-29(37-26)36-25-6-5-17-14-38(8-7-23(17)35-25)28(40)19-9-20(10-19)32-4/h5-6,11-13,15,19-20,32H,7-10,14H2,1-4H3,(H,33,35,36,37) JNCFUVQWIVLATB-UHFFFAOYSA-N 444521 US10662186, Compound 42::US10988476, Compound I-42 Cyclin-dependent kinase 6 Homo sapiens 13.4 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444521&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196823 440706768 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028368 CN(C)CCNC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H31F2N9O/c1-16-33-26-20(29)12-18(13-23(26)39(16)19-5-6-19)25-21(30)14-32-27(36-25)35-24-7-4-17-15-38(10-8-22(17)34-24)28(40)31-9-11-37(2)3/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,31,40)(H,32,34,35,36) ISWNVTVWJJQFQV-UHFFFAOYSA-N 444522 US10662186, Compound 43::US10988476, Compound I-43 Cyclin-dependent kinase 6 Homo sapiens 3.57 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444522&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196831 440706769 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028371 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCN(C)C)ncc1F InChI=1S/C28H33F2N9O/c1-16(2)39-17(3)33-26-20(29)12-19(13-23(26)39)25-21(30)14-32-27(36-25)35-24-7-6-18-15-38(10-8-22(18)34-24)28(40)31-9-11-37(4)5/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,31,40)(H,32,34,35,36) SALMKXDVOXFTFG-UHFFFAOYSA-N 444523 US10662186, Compound 44::US10988476, Compound I-44 Cyclin-dependent kinase 6 Homo sapiens 2.82 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444523&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196817 440706770 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028374 CC(C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H27F2N7/c1-14(2)34-9-8-21-16(13-34)4-7-23(31-21)32-26-29-12-20(28)24(33-26)17-10-19(27)25-22(11-17)35(15(3)30-25)18-5-6-18/h4,7,10-12,14,18H,5-6,8-9,13H2,1-3H3,(H,29,31,32,33) JZGPEQNPASOUFO-UHFFFAOYSA-N 444524 US10662186, Compound 45::US10988476, Compound I-45 Cyclin-dependent kinase 6 Homo sapiens 22.7 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444524&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196815 440706771 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028377 CN(C)CCOC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O2/c1-16-32-26-20(29)12-18(13-23(26)38(16)19-5-6-19)25-21(30)14-31-27(35-25)34-24-7-4-17-15-37(9-8-22(17)33-24)28(39)40-11-10-36(2)3/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,31,33,34,35) XLZHLULRODUOPS-UHFFFAOYSA-N 444525 US10662186, Compound 46::US10988476, Compound I-46 Cyclin-dependent kinase 6 Homo sapiens 3.42 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444525&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196818 440706772 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028380 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 6 Homo sapiens 4.16 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028383 C[C@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m0/s1 IIHKFIWSMAISST-HNNXBMFYSA-N 444528 US10662186, Compound 48::US10988476, Compound I-48 Cyclin-dependent kinase 6 Homo sapiens 4.88 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444528&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196802 440706775 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028386 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) VZPLQNFSKCQLPB-UHFFFAOYSA-N 444529 US10662186, Compound 49::US10988476, Compound I-49 Cyclin-dependent kinase 6 Homo sapiens 5.17 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444529&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196801 440706776 C04080 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028389 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F InChI=1S/C26H26F2N8O2/c1-14-31-24-18(27)10-16(11-21(24)36(14)17-3-4-17)23-19(28)12-30-25(34-23)33-22-5-2-15-13-35(8-6-20(15)32-22)26(38)29-7-9-37/h2,5,10-12,17,37H,3-4,6-9,13H2,1H3,(H,29,38)(H,30,32,33,34) XTSFMAFWRLGELC-UHFFFAOYSA-N 444530 US10662186, Compound 50::US10988476, Compound I-50 Cyclin-dependent kinase 6 Homo sapiens 3.94 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444530&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196796 440706777 C04080 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028392 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-32-26-19(28)10-17(11-22(26)37(15)18-4-3-5-18)25-20(29)12-31-27(35-25)34-23-7-6-16-14-36(24(38)13-30-2)9-8-21(16)33-23/h6-7,10-12,18,30H,3-5,8-9,13-14H2,1-2H3,(H,31,33,34,35) UTDIUAOBXDHROL-UHFFFAOYSA-N 444531 US10662186, Compound 51::US10988476, Compound I-51 Cyclin-dependent kinase 6 Homo sapiens 2.88 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444531&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196799 440706778 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028395 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-31-26-20(28)12-18(13-23(26)37(16)19-5-6-19)25-21(29)14-30-27(34-25)33-24-7-4-17-15-36(11-10-35(2)3)9-8-22(17)32-24/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,30,32,33,34) UZUCFTPPULEGQO-UHFFFAOYSA-N 444532 US10662186, Compound 52::US10988476, Compound I-52 Cyclin-dependent kinase 6 Homo sapiens 3.81 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444532&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196740 440706779 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028398 CN(C)CCC(=C)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17(9-11-37(3)4)38-12-10-24-19(16-38)5-8-26(34-24)35-29-32-15-23(31)27(36-29)20-13-22(30)28-25(14-20)39(18(2)33-28)21-6-7-21/h5,8,13-15,21H,1,6-7,9-12,16H2,2-4H3,(H,32,34,35,36) DWVMFMWELQFMNJ-UHFFFAOYSA-N 493976 US10988476, Compound I-53 Cyclin-dependent kinase 6 Homo sapiens 5.46 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493976&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 154612565 447112500 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028401 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)11-18(12-23(27)38(16)19-5-4-6-19)26-21(30)13-31-28(35-26)34-24-8-7-17-14-37(10-9-22(17)33-24)25(39)15-36(2)3/h7-8,11-13,19H,4-6,9-10,14-15H2,1-3H3,(H,31,33,34,35) KPCVCNZJVUSNOC-UHFFFAOYSA-N 493977 US10988476, Compound I-54 Cyclin-dependent kinase 6 Homo sapiens 7.50 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493977&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196800 447112501 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028416 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)10-19(11-23(27)38(16)13-17-4-5-17)26-21(30)12-31-28(35-26)34-24-7-6-18-14-37(9-8-22(18)33-24)25(39)15-36(2)3/h6-7,10-12,17H,4-5,8-9,13-15H2,1-3H3,(H,31,33,34,35) FEBXDTFBHZJUJT-UHFFFAOYSA-N 444540 US10662186, Compound 60::US10988476, Compound I-60 Cyclin-dependent kinase 6 Homo sapiens 3.47 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444540&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196821 440706787 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028419 CN(C)CCN(C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H33F2N9O/c1-17-33-27-21(30)13-19(14-24(27)40(17)20-6-7-20)26-22(31)15-32-28(36-26)35-25-8-5-18-16-39(10-9-23(18)34-25)29(41)38(4)12-11-37(2)3/h5,8,13-15,20H,6-7,9-12,16H2,1-4H3,(H,32,34,35,36) IVKYJVDFJKEXIH-UHFFFAOYSA-N 444541 US10662186, Compound 61::US10988476, Compound I-61 Cyclin-dependent kinase 6 Homo sapiens 2.55 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444541&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196824 440706788 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028422 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)[C@@H](C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35)/t16-/m1/s1 SSIOYGMEKCPFAV-MRXNPFEDSA-N 444542 US10662186, Compound 62::US10988476, Compound I-62 Cyclin-dependent kinase 6 Homo sapiens 4.51 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444542&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196777 440706789 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028425 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C27H32F2N8/c1-16(2)37-17(3)31-26-20(28)12-19(13-23(26)37)25-21(29)14-30-27(34-25)33-24-7-6-18-15-36(11-10-35(4)5)9-8-22(18)32-24/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,30,32,33,34) KGMVZSJAPXYTKH-UHFFFAOYSA-N 444543 US10662186, Compound 63::US10988476, Compound I-63 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444543&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196825 440706790 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028428 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(O)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H29FN8O2/c1-15-30-26-21(36(15)18-5-6-18)10-17(11-22(26)37)25-19(28)12-29-27(33-25)32-23-7-4-16-13-35(9-8-20(16)31-23)24(38)14-34(2)3/h4,7,10-12,18,37H,5-6,8-9,13-14H2,1-3H3,(H,29,31,32,33) YOPAUTRVBICJOC-UHFFFAOYSA-N 493982 US10988476, Compound I-64 Cyclin-dependent kinase 6 Homo sapiens 8.47 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493982&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196849 447112506 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028431 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36) QXBRBWDRQIISAT-UHFFFAOYSA-N 444545 US10662186, Compound 65::US10662186, Compound 67::US10988476, Compound I-65 Cyclin-dependent kinase 6 Homo sapiens 3.75 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444545&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196850 440706791 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028434 CN[C@H](C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-14(30-3)26(38)36-9-8-21-16(13-36)4-7-23(33-21)34-27-31-12-20(29)24(35-27)17-10-19(28)25-22(11-17)37(15(2)32-25)18-5-6-18/h4,7,10-12,14,18,30H,5-6,8-9,13H2,1-3H3,(H,31,33,34,35)/t14-/m1/s1 PMCGYDRAUVMLBE-CQSZACIVSA-N 444546 US10662186, Compound 66::US10988476, Compound I-66 Cyclin-dependent kinase 6 Homo sapiens 6.36 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444546&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196853 440706792 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028437 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)[C@@H]2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36)/t22-/m0/s1 QXBRBWDRQIISAT-QFIPXVFZSA-N 493985 US10988476, Compound I-67 Cyclin-dependent kinase 6 Homo sapiens 6.24 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493985&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196873 447112509 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028440 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2,3)4)21-17(26)12-28-23(32-21)31-20-6-5-14-11-27-8-7-18(14)30-20/h5-6,9-10,12,27H,7-8,11H2,1-4H3,(H,28,30,31,32) LIJUCWLALFXGCL-UHFFFAOYSA-N 444548 US10662186, Compound 68::US10988476, Compound I-68 Cyclin-dependent kinase 6 Homo sapiens 2.97 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444548&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196856 440706793 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028443 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C28H34F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2,3)4)25-21(30)15-31-27(35-25)34-24-8-7-18-16-37(12-11-36(5)6)10-9-22(18)33-24/h7-8,13-15H,9-12,16H2,1-6H3,(H,31,33,34,35) AKGTYSYXMRZPBV-UHFFFAOYSA-N 444549 US10662186, Compound 69::US10988476, Compound I-69 Cyclin-dependent kinase 6 Homo sapiens 1.57 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444549&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196857 440706794 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028446 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)13-19(14-24(27)38(17)20-6-7-20)26-22(30)15-31-28(35-26)34-25-8-5-18-16-37(11-4-10-36(2)3)12-9-23(18)33-25/h5,8,13-15,20H,4,6-7,9-12,16H2,1-3H3,(H,31,33,34,35) GYDXFTMHNUETBY-UHFFFAOYSA-N 444550 US10662186, Compound 70::US10988476, Compound I-70 Cyclin-dependent kinase 6 Homo sapiens 5.51 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444550&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196851 440706795 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028449 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CC#C)CCc3n2)ncc1F InChI=1S/C29H32F2N8/c1-6-10-37(5)12-13-38-11-9-24-20(17-38)7-8-26(34-24)35-29-32-16-23(31)27(36-29)21-14-22(30)28-25(15-21)39(18(2)3)19(4)33-28/h1,7-8,14-16,18H,9-13,17H2,2-5H3,(H,32,34,35,36) UGMXVKWXOFIULK-UHFFFAOYSA-N 444551 US10662186, Compound 71::US10988476, Compound I-71 Cyclin-dependent kinase 6 Homo sapiens 3.47 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444551&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196855 440706796 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028452 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C2CCN(CC#C)C2)ncc1F InChI=1S/C30H32F2N8/c1-5-10-38-11-8-22(17-38)39-12-9-25-20(16-39)6-7-27(35-25)36-30-33-15-24(32)28(37-30)21-13-23(31)29-26(14-21)40(18(2)3)19(4)34-29/h1,6-7,13-15,18,22H,8-12,16-17H2,2-4H3,(H,33,35,36,37) TWNUIDQVTSUXKY-UHFFFAOYSA-N 493992 US10988476, Compound I-72 Cyclin-dependent kinase 6 Homo sapiens 2.58 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493992&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196854 447112516 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028455 CN(C)C[C@H](O)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8O/c1-16-32-27-21(29)10-18(11-24(27)38(16)19-5-6-19)26-22(30)12-31-28(35-26)34-25-7-4-17-13-37(9-8-23(17)33-25)15-20(39)14-36(2)3/h4,7,10-12,19-20,39H,5-6,8-9,13-15H2,1-3H3,(H,31,33,34,35)/t20-/m0/s1 UQAHWAQRLXARGK-FQEVSTJZSA-N 444554 US10662186, Compound 73::US10988476, Compound I-73 Cyclin-dependent kinase 6 Homo sapiens 6.91 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444554&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196741 440706799 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028458 CN1CCC[C@@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m1/s1 DSMBDRWDECFDNR-OAQYLSRUSA-N 444555 US10662186, Compound 74::US10988476, Compound I-74 Cyclin-dependent kinase 6 Homo sapiens 3.15 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444555&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196858 440706800 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028461 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC4CCCN4CC#C)CCc3n2)ncc1F InChI=1S/C31H34F2N8/c1-5-11-40-12-6-7-23(40)18-39-13-10-26-21(17-39)8-9-28(36-26)37-31-34-16-25(33)29(38-31)22-14-24(32)30-27(15-22)41(19(2)3)20(4)35-30/h1,8-9,14-16,19,23H,6-7,10-13,17-18H2,2-4H3,(H,34,36,37,38) IZSLXRORDBBGDE-UHFFFAOYSA-N 444556 US10662186, Compound 75::US10988476, Compound I-75 Cyclin-dependent kinase 6 Homo sapiens 5.16 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444556&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196859 440706801 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028464 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC#C)CCc3n2)ncc1F InChI=1S/C26H25F2N7/c1-5-9-34-10-8-21-17(14-34)6-7-23(31-21)32-26-29-13-20(28)24(33-26)18-11-19(27)25-22(12-18)35(15(2)3)16(4)30-25/h1,6-7,11-13,15H,8-10,14H2,2-4H3,(H,29,31,32,33) ZYONZFOMVOBYKS-UHFFFAOYSA-N 444557 US10662186, Compound 76::US10988476, Compound I-76 Cyclin-dependent kinase 6 Homo sapiens 4.58 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444557&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196677 440706802 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028467 C[C@@H](N)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-14(29)12-35-8-7-21-16(13-35)3-6-23(32-21)33-26-30-11-20(28)24(34-26)17-9-19(27)25-22(10-17)36(15(2)31-25)18-4-5-18/h3,6,9-11,14,18H,4-5,7-8,12-13,29H2,1-2H3,(H,30,32,33,34)/t14-/m1/s1 HWUQUQZRNDZMLC-CQSZACIVSA-N 444558 US10662186, Compound 77::US10988476, Compound I-77 Cyclin-dependent kinase 6 Homo sapiens 3.15 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444558&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196720 440706803 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028470 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CC(C)(C)N)CCc3n2)ncc1F InChI=1S/C27H30F2N8/c1-15-32-25-19(28)10-17(11-22(25)37(15)18-5-6-18)24-20(29)12-31-26(35-24)34-23-7-4-16-13-36(14-27(2,3)30)9-8-21(16)33-23/h4,7,10-12,18H,5-6,8-9,13-14,30H2,1-3H3,(H,31,33,34,35) RAIPOUVWZMOUJL-UHFFFAOYSA-N 444559 US10662186, Compound 78::US10988476, Compound I-78 Cyclin-dependent kinase 6 Homo sapiens 5.60 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444559&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196698 440706804 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028473 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC#CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H32F2N8/c1-18(2)39-19(3)33-28-22(30)14-21(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-20-17-38(13-10-24(20)34-26)12-7-6-11-37(4)5/h8-9,14-16,18H,10-13,17H2,1-5H3,(H,32,34,35,36) SUEYATVNHWMTSO-UHFFFAOYSA-N 444560 US10662186, Compound 79::US10988476, Compound I-79 Cyclin-dependent kinase 6 Homo sapiens 2.69 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444560&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196679 440706805 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028476 C[C@H](CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1)N(C)C InChI=1S/C28H32F2N8/c1-16(36(3)4)14-37-10-9-23-18(15-37)5-8-25(33-23)34-28-31-13-22(30)26(35-28)19-11-21(29)27-24(12-19)38(17(2)32-27)20-6-7-20/h5,8,11-13,16,20H,6-7,9-10,14-15H2,1-4H3,(H,31,33,34,35)/t16-/m1/s1 WIAMCDYCLOMHKF-MRXNPFEDSA-N 444561 US10662186, Compound 80::US10988476, Compound I-80 Cyclin-dependent kinase 6 Homo sapiens 3.67 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444561&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196724 440706806 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028479 C[C@H](N)CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-14(29)12-35-8-7-21-16(13-35)3-6-23(32-21)33-26-30-11-20(28)24(34-26)17-9-19(27)25-22(10-17)36(15(2)31-25)18-4-5-18/h3,6,9-11,14,18H,4-5,7-8,12-13,29H2,1-2H3,(H,30,32,33,34)/t14-/m0/s1 HWUQUQZRNDZMLC-AWEZNQCLSA-N 444562 US10662186, Compound 81::US10988476, Compound I-81 Cyclin-dependent kinase 6 Homo sapiens 3.34 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444562&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196681 440706807 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028482 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H27F2N7/c1-4-17(5-2)34-14(3)30-24-18(26)10-16(11-21(24)34)23-19(27)13-29-25(33-23)32-22-7-6-15-12-28-9-8-20(15)31-22/h6-7,10-11,13,17,28H,4-5,8-9,12H2,1-3H3,(H,29,31,32,33) YPMOBRWHNOTUIL-UHFFFAOYSA-N 444563 US10662186, Compound 82::US10988476, Compound I-82 Cyclin-dependent kinase 6 Homo sapiens 3.16 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444563&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196672 440706808 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028485 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H36F2N8/c1-6-21(7-2)39-18(3)33-28-22(30)14-20(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(4)5)11-10-24(19)34-26/h8-9,14-16,21H,6-7,10-13,17H2,1-5H3,(H,32,34,35,36) POTKDJWRAMHALZ-UHFFFAOYSA-N 444564 US10662186, Compound 83::US10988476, Compound I-83 Cyclin-dependent kinase 6 Homo sapiens 1.55 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444564&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196685 440706809 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028488 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H25F2N7/c1-13(15-3-4-15)34-14(2)30-24-18(26)9-17(10-21(24)34)23-19(27)12-29-25(33-23)32-22-6-5-16-11-28-8-7-20(16)31-22/h5-6,9-10,12-13,15,28H,3-4,7-8,11H2,1-2H3,(H,29,31,32,33) ANELMUPUYRZVHZ-UHFFFAOYSA-N 444565 US10662186, Compound 84::US10988476, Compound I-84 Cyclin-dependent kinase 6 Homo sapiens 3.21 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444565&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196684 440706810 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028491 C[C@@H](CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1)N(C)C InChI=1S/C28H32F2N8/c1-16(36(3)4)14-37-10-9-23-18(15-37)5-8-25(33-23)34-28-31-13-22(30)26(35-28)19-11-21(29)27-24(12-19)38(17(2)32-27)20-6-7-20/h5,8,11-13,16,20H,6-7,9-10,14-15H2,1-4H3,(H,31,33,34,35)/t16-/m0/s1 WIAMCDYCLOMHKF-INIZCTEOSA-N 444566 US10662186, Compound 85::US10988476, Compound I-85 Cyclin-dependent kinase 6 Homo sapiens 2.54 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444566&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196687 440706811 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028494 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H34F2N8/c1-17(19-5-6-19)39-18(2)33-28-22(30)13-21(14-25(28)39)27-23(31)15-32-29(36-27)35-26-8-7-20-16-38(12-11-37(3)4)10-9-24(20)34-26/h7-8,13-15,17,19H,5-6,9-12,16H2,1-4H3,(H,32,34,35,36) VUKGJVXJRDQYFA-UHFFFAOYSA-N 444567 US10662186, Compound 86::US10988476, Compound I-86 Cyclin-dependent kinase 6 Homo sapiens 1.49 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444567&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196673 440706812 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028497 Cc1nc2c(F)cc(cc2n1C1(C)CC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H23F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2)6-7-24)21-17(26)12-28-23(32-21)31-20-4-3-14-11-27-8-5-18(14)30-20/h3-4,9-10,12,27H,5-8,11H2,1-2H3,(H,28,30,31,32) BONJLZFNDLMWRE-UHFFFAOYSA-N 444568 US10662186, Compound 87::US10988476, Compound I-87 Cyclin-dependent kinase 6 Homo sapiens 2.21 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444568&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196674 440706813 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028500 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2)8-9-28)25-21(30)15-31-27(35-25)34-24-6-5-18-16-37(12-11-36(3)4)10-7-22(18)33-24/h5-6,13-15H,7-12,16H2,1-4H3,(H,31,33,34,35) SPKWRLBKVPRPMT-UHFFFAOYSA-N 444569 US10662186, Compound 88::US10988476, Compound I-88 Cyclin-dependent kinase 6 Homo sapiens 1.41 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444569&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196688 440706814 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028503 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC[Si](C)(C)C)CCc3n2)ncc1F InChI=1S/C28H35F2N7Si/c1-17(2)37-18(3)32-27-21(29)13-20(14-24(27)37)26-22(30)15-31-28(35-26)34-25-8-7-19-16-36(10-9-23(19)33-25)11-12-38(4,5)6/h7-8,13-15,17H,9-12,16H2,1-6H3,(H,31,33,34,35) KZLNMNBKUXXLSY-UHFFFAOYSA-N 444570 US10662186, Compound 89::US10988476, Compound I-89 Cyclin-dependent kinase 6 Homo sapiens 17.9 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444570&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763674 440706815 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028506 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-9-8-19-17-38(12-7-11-37(5)6)13-10-23(19)34-25/h8-9,14-16H,7,10-13,17H2,1-6H3,(H,32,34,35,36) UVMVCEDKKHGTIW-UHFFFAOYSA-N 444571 US10662186, Compound 90::US10988476, Compound I-90 Cyclin-dependent kinase 6 Homo sapiens 1.56 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444571&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196721 440706816 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028509 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(N)=N)CCc3n2)ncc1F InChI=1S/C27H32F2N10/c1-15(2)39-16(3)33-25-19(28)11-18(12-22(25)39)24-20(29)13-32-27(36-24)35-23-6-5-17-14-38(8-7-21(17)34-23)10-9-37(4)26(30)31/h5-6,11-13,15H,7-10,14H2,1-4H3,(H3,30,31)(H,32,34,35,36) CEIAWFVLEUQXHI-UHFFFAOYSA-N 444572 US10662186, Compound 91::US10988476, Compound I-91 Cyclin-dependent kinase 6 Homo sapiens 1.70 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444572&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196686 440706817 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028512 CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H34F2N8O/c1-17-33-27-20(30)13-19(14-23(27)39(17)29(2,3)4)26-21(31)15-32-28(36-26)35-24-8-7-18-16-38(12-9-22(18)34-24)25(40)10-11-37(5)6/h7-8,13-15H,9-12,16H2,1-6H3,(H,32,34,35,36) AKDZNPFQMDRCMU-UHFFFAOYSA-N 444573 US10662186, Compound 92::US10988476, Compound I-92 Cyclin-dependent kinase 6 Homo sapiens 1.39 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444573&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196689 440706818 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028515 CN1CCO[C@@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m1/s1 PBDNNWWYSHCMCH-OAQYLSRUSA-N 444574 US10662186, Compound 93::US10988476, Compound I-93 Cyclin-dependent kinase 6 Homo sapiens 1.33 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444574&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196700 440706819 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028518 CN1CCO[C@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m0/s1 PBDNNWWYSHCMCH-NRFANRHFSA-N 444575 US10662186, Compound 94::US10988476, Compound I-94 Cyclin-dependent kinase 6 Homo sapiens 1.37 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444575&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196726 440706820 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028521 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C\C=N\O)CCc3n2)ncc1F InChI=1S/C25H26F2N8O/c1-14(2)35-15(3)30-24-18(26)10-17(11-21(24)35)23-19(27)12-28-25(33-23)32-22-5-4-16-13-34(9-7-29-36)8-6-20(16)31-22/h4-5,7,10-12,14,36H,6,8-9,13H2,1-3H3,(H,28,31,32,33)/b29-7+ XHCXEGJOAXJLFH-HBRQFSJYSA-N 444576 US10662186, Compound 95::US10988476, Compound I-95 Cyclin-dependent kinase 6 Homo sapiens 2.02 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444576&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196691 440706821 C02658 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028524 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(\C)=N/O)CCc3n2)ncc1F InChI=1S/C28H33F2N9O/c1-16(2)39-17(3)32-27-21(29)12-20(13-24(27)39)26-22(30)14-31-28(35-26)34-25-7-6-19-15-38(9-8-23(19)33-25)11-10-37(5)18(4)36-40/h6-7,12-14,16,40H,8-11,15H2,1-5H3,(H,31,33,34,35)/b36-18- HCAPKVUYVLOOHA-VHFSBPNMSA-N 494016 US10988476, Compound I-200::US10988476, Compound I-97 Cyclin-dependent kinase 6 Homo sapiens 2.11 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494016&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196702 447112540 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028527 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN=C(N)N)CCc3n2)ncc1F InChI=1S/C26H30F2N10/c1-14(2)38-15(3)33-24-18(27)10-17(11-21(24)38)23-19(28)12-32-26(36-23)35-22-5-4-16-13-37(8-6-20(16)34-22)9-7-31-25(29)30/h4-5,10-12,14H,6-9,13H2,1-3H3,(H4,29,30,31)(H,32,34,35,36) FTFHCSWIOVPGGS-UHFFFAOYSA-N 444577 US10662186, Compound 97::US10988476, Compound I-98 Cyclin-dependent kinase 6 Homo sapiens 5.01 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444577&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196690 440706822 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028530 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CB(O)O)CCc3n2)ncc1F InChI=1S/C27H33BF2N8O2/c1-16(2)38-17(3)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-27(35-25)34-24-6-5-18-14-37(8-7-22(18)33-24)10-9-36(4)15-28(39)40/h5-6,11-13,16,39-40H,7-10,14-15H2,1-4H3,(H,31,33,34,35) GNEARXSVRDSWKT-UHFFFAOYSA-N 494018 US10988476, Compound I-101 Cyclin-dependent kinase 6 Homo sapiens 2.90 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494018&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763686 447112542 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028533 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCCC5)c4c3)ccc2C1 InChI=1S/C30H36F2N8/c1-19-34-29-23(31)15-21(16-26(29)40(19)22-7-5-4-6-8-22)28-24(32)17-33-30(37-28)36-27-10-9-20-18-39(14-13-38(2)3)12-11-25(20)35-27/h9-10,15-17,22H,4-8,11-14,18H2,1-3H3,(H,33,35,36,37) BAPMZESGRJMZNL-UHFFFAOYSA-N 444580 US10662186, Compound 102::US10988476, Compound I-102 Cyclin-dependent kinase 6 Homo sapiens 2.41 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444580&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196692 440706825 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028536 C[C@@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1 QPSCTAMMABVQIH-KRWDZBQOSA-N 444581 US10662186, Compound 103::US10662186, Compound 106::US10988476, Compound I-106 Cyclin-dependent kinase 6 Homo sapiens 0.970 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444581&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196710 440706826 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028539 C[C@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m1/s1 QPSCTAMMABVQIH-QGZVFWFLSA-N 494021 US10988476, Compound I-104 Cyclin-dependent kinase 6 Homo sapiens 9.25 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494021&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196694 447112545 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028542 C[C@@H]1N(CCN(C)C)CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C29H36F2N8/c1-17-20-8-9-25(34-23(20)10-11-38(17)13-12-37(6)7)35-28-32-16-22(31)26(36-28)19-14-21(30)27-24(15-19)39(18(2)33-27)29(3,4)5/h8-9,14-17H,10-13H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1 QPSCTAMMABVQIH-KRWDZBQOSA-N 444581 US10662186, Compound 103::US10662186, Compound 106::US10988476, Compound I-106 Cyclin-dependent kinase 6 Homo sapiens 2.67 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444581&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196710 440706826 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028545 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)P(C)(C)=O)CCc3n2)ncc1F InChI=1S/C28H35F2N8OP/c1-17(2)38-18(3)32-27-21(29)13-20(14-24(27)38)26-22(30)15-31-28(35-26)34-25-8-7-19-16-37(10-9-23(19)33-25)12-11-36(4)40(5,6)39/h7-8,13-15,17H,9-12,16H2,1-6H3,(H,31,33,34,35) YFRIHUMUDOXHTG-UHFFFAOYSA-N 444584 US10662186, Compound 107::US10988476, Compound I-107 Cyclin-dependent kinase 6 Homo sapiens 4.59 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444584&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196727 440706827 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028548 C[C@H]1CC[C@@H](CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C31H38F2N8/c1-19-5-8-23(9-6-19)41-20(2)35-30-24(32)15-22(16-27(30)41)29-25(33)17-34-31(38-29)37-28-10-7-21-18-40(14-13-39(3)4)12-11-26(21)36-28/h7,10,15-17,19,23H,5-6,8-9,11-14,18H2,1-4H3,(H,34,36,37,38)/t19-,23- IHSJJFRMGGAMME-UILWBTOOSA-N 444585 US10662186, Compound 108::US10988476, Compound I-108 Cyclin-dependent kinase 6 Homo sapiens 2.23 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444585&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196703 440706828 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028551 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 6 Homo sapiens 3.86 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028554 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(N)=S)CCc3n2)ncc1F InChI=1S/C27H31F2N9S/c1-15(2)38-16(3)32-25-19(28)11-18(12-22(25)38)24-20(29)13-31-27(35-24)34-23-6-5-17-14-37(8-7-21(17)33-23)10-9-36(4)26(30)39/h5-6,11-13,15H,7-10,14H2,1-4H3,(H2,30,39)(H,31,33,34,35) DKTHMZUTCUNQAZ-UHFFFAOYSA-N 444587 US10662186, Compound 110::US10988476, Compound I-110 Cyclin-dependent kinase 6 Homo sapiens 5.89 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444587&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196715 440706830 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028557 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 6 Homo sapiens 2.98 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028560 C[C@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1CCN(C)C InChI=1S/C29H36F2N8/c1-17-12-23-19(16-38(17)11-10-37(6)7)8-9-25(34-23)35-28-32-15-22(31)26(36-28)20-13-21(30)27-24(14-20)39(18(2)33-27)29(3,4)5/h8-9,13-15,17H,10-12,16H2,1-7H3,(H,32,34,35,36)/t17-/m0/s1 XKPZMRRASYJBKC-KRWDZBQOSA-N 494028 US10988476, Compound I-112 Cyclin-dependent kinase 6 Homo sapiens 1.70 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494028&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196676 447112552 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028563 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCS(C)(=O)=NC#N)CCc3n2)ncc1F InChI=1S/C27H29F2N9OS/c1-16(2)38-17(3)33-26-20(28)11-19(12-23(26)38)25-21(29)13-31-27(36-25)35-24-6-5-18-14-37(8-7-22(18)34-24)9-10-40(4,39)32-15-30/h5-6,11-13,16H,7-10,14H2,1-4H3,(H,31,34,35,36) PEMNVVTZKGRLSX-UHFFFAOYSA-N 494029 US10988476, Compound I-114 Cyclin-dependent kinase 6 Homo sapiens 1.77 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494029&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196695 447112553 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028566 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)12-20(13-24(27)38(17)15-18-4-5-18)26-22(30)14-31-28(35-26)34-25-7-6-19-16-37(11-10-36(2)3)9-8-23(19)33-25/h6-7,12-14,18H,4-5,8-11,15-16H2,1-3H3,(H,31,33,34,35) IUYLNMPIDQAYSG-UHFFFAOYSA-N 444591 US10662186, Compound 126::US10988476, Compound I-126 Cyclin-dependent kinase 6 Homo sapiens 6.26 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444591&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196705 440706832 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028569 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 6 Homo sapiens 4.88 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028572 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C[C@@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C28H32F2N8O/c1-16(2)38-17(3)33-27-21(29)10-19(11-24(27)38)26-22(30)13-32-28(36-26)35-25-5-4-18-14-37(8-6-23(18)34-25)15-20-12-31-7-9-39-20/h4-5,10-11,13,16,20,31H,6-9,12,14-15H2,1-3H3,(H,32,34,35,36)/t20-/m0/s1 PUXKEKPYASIYGT-FQEVSTJZSA-N 494032 US10988476, Compound I-129 Cyclin-dependent kinase 6 Homo sapiens 1.13 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494032&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 154612573 447112556 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028575 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C[C@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C28H32F2N8O/c1-16(2)38-17(3)33-27-21(29)10-19(11-24(27)38)26-22(30)13-32-28(36-26)35-25-5-4-18-14-37(8-6-23(18)34-25)15-20-12-31-7-9-39-20/h4-5,10-11,13,16,20,31H,6-9,12,14-15H2,1-3H3,(H,32,34,35,36)/t20-/m1/s1 PUXKEKPYASIYGT-HXUWFJFHSA-N 494033 US10988476, Compound I-130 Cyclin-dependent kinase 6 Homo sapiens 1.48 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494033&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 154612566 447112557 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028578 CN1CCC[C@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m0/s1 DSMBDRWDECFDNR-NRFANRHFSA-N 444595 US10662186, Compound 131::US10988476, Compound I-131 Cyclin-dependent kinase 6 Homo sapiens 1.41 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444595&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196723 440706835 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028581 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCNC(N)=N)CCc3n2)ncc1F InChI=1S/C26H30F2N10/c1-14(2)38-15(3)33-24-18(27)10-17(11-21(24)38)23-19(28)12-32-26(36-23)35-22-5-4-16-13-37(8-6-20(16)34-22)9-7-31-25(29)30/h4-5,10-12,14H,6-9,13H2,1-3H3,(H4,29,30,31)(H,32,34,35,36) FTFHCSWIOVPGGS-UHFFFAOYSA-N 444596 US10662186, Compound 132::US10988476, Compound I-132 Cyclin-dependent kinase 6 Homo sapiens 0.770 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444596&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196690 440706836 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028584 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CCNC(N)=N)CCc3n2)ncc1F InChI=1S/C29H37F2N11/c1-17(2)42-18(3)36-27-21(30)13-20(14-24(27)42)26-22(31)15-35-29(39-26)38-25-6-5-19-16-41(9-7-23(19)37-25)12-11-40(4)10-8-34-28(32)33/h5-6,13-15,17H,7-12,16H2,1-4H3,(H4,32,33,34)(H,35,37,38,39) PQWACVUXFPZERA-UHFFFAOYSA-N 444597 US10662186, Compound 133::US10988476, Compound I-133 Cyclin-dependent kinase 6 Homo sapiens 1.82 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444597&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196717 440706837 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028587 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CC[Si](C)(C)C)CCc3n2)ncc1F InChI=1S/C31H42F2N8Si/c1-20(2)41-21(3)35-30-24(32)16-23(17-27(30)41)29-25(33)18-34-31(38-29)37-28-9-8-22-19-40(11-10-26(22)36-28)13-12-39(4)14-15-42(5,6)7/h8-9,16-18,20H,10-15,19H2,1-7H3,(H,34,36,37,38) SXVVQLGGDQUNKQ-UHFFFAOYSA-N 444598 US10662186, Compound 134::US10988476, Compound I-134 Cyclin-dependent kinase 6 Homo sapiens 1.59 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444598&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763692 440706838 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028590 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C(=S)n4ccnc4)CCc3n2)ncc1F InChI=1S/C30H32F2N10S/c1-18(2)42-19(3)35-28-22(31)13-21(14-25(28)42)27-23(32)15-34-29(38-27)37-26-6-5-20-16-40(9-7-24(20)36-26)12-11-39(4)30(43)41-10-8-33-17-41/h5-6,8,10,13-15,17-18H,7,9,11-12,16H2,1-4H3,(H,34,36,37,38) QDTMPQOORBQFIG-UHFFFAOYSA-N 444599 US10662186, Compound 135::US10988476, Compound I-135 Cyclin-dependent kinase 6 Homo sapiens 111 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444599&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196728 440706839 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028593 Cc1nc2c(F)cc(cc2n1C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C21H19F2N7/c1-11-26-20-14(22)7-13(8-17(20)30(11)2)19-15(23)10-25-21(29-19)28-18-4-3-12-9-24-6-5-16(12)27-18/h3-4,7-8,10,24H,5-6,9H2,1-2H3,(H,25,27,28,29) MSIYPAKNNNBUFM-UHFFFAOYSA-N 444600 US10662186, Compound 136::US10662186, Compound 139::US10988476, Compound I-136 Cyclin-dependent kinase 6 Homo sapiens 84.2 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444600&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196725 440706840 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028596 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC(N)=NO)CCc3n2)ncc1F InChI=1S/C25H27F2N9O/c1-13(2)36-14(3)30-24-17(26)8-16(9-20(24)36)23-18(27)10-29-25(33-23)32-22-5-4-15-11-35(12-21(28)34-37)7-6-19(15)31-22/h4-5,8-10,13,37H,6-7,11-12H2,1-3H3,(H2,28,34)(H,29,31,32,33) BENAWDZPBLPFCU-UHFFFAOYSA-N 494040 US10988476, Compound I-137 Cyclin-dependent kinase 6 Homo sapiens 4.78 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494040&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 145763685 447112563 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028599 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C)c4c3)ccc2C1 InChI=1S/C25H28F2N8/c1-15-29-24-18(26)11-17(12-21(24)34(15)4)23-19(27)13-28-25(32-23)31-22-6-5-16-14-35(10-9-33(2)3)8-7-20(16)30-22/h5-6,11-13H,7-10,14H2,1-4H3,(H,28,30,31,32) DCHQNZAIUFIFEB-UHFFFAOYSA-N 444602 US10662186, Compound 138::US10988476, Compound I-138 Cyclin-dependent kinase 6 Homo sapiens 33.0 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444602&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196729 440706842 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028602 CCn1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C22H21F2N7/c1-3-31-12(2)27-21-15(23)8-14(9-18(21)31)20-16(24)11-26-22(30-20)29-19-5-4-13-10-25-7-6-17(13)28-19/h4-5,8-9,11,25H,3,6-7,10H2,1-2H3,(H,26,28,29,30) FXNYFKNNCUKUAE-UHFFFAOYSA-N 494042 US10988476, Compound I-139 Cyclin-dependent kinase 6 Homo sapiens 29.3 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494042&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196714 447112565 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028605 CCn1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C26H30F2N8/c1-5-36-16(2)30-25-19(27)12-18(13-22(25)36)24-20(28)14-29-26(33-24)32-23-7-6-17-15-35(11-10-34(3)4)9-8-21(17)31-23/h6-7,12-14H,5,8-11,15H2,1-4H3,(H,29,31,32,33) JNZTWAOEOYBNNP-UHFFFAOYSA-N 444604 US10662186, Compound 140::US10988476, Compound I-140 Cyclin-dependent kinase 6 Homo sapiens 5.67 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444604&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196730 440706843 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028608 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-15-31-25-19(27)11-17(12-22(25)36(15)18-4-5-18)24-20(28)13-30-26(34-24)33-23-6-3-16-14-35(10-8-29-2)9-7-21(16)32-23/h3,6,11-13,18,29H,4-5,7-10,14H2,1-2H3,(H,30,32,33,34) JRGMQQCQWFMKLA-UHFFFAOYSA-N 444605 US10662186, Compound 142::US10988476, Compound I-142 Cyclin-dependent kinase 6 Homo sapiens 3.25 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444605&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196895 440706844 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028611 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCOCC4)CCc3n2)ncc1F InChI=1S/C30H36F2N8O/c1-19-34-28-22(31)15-21(16-25(28)40(19)30(2,3)4)27-23(32)17-33-29(37-27)36-26-6-5-20-18-39(8-7-24(20)35-26)10-9-38-11-13-41-14-12-38/h5-6,15-17H,7-14,18H2,1-4H3,(H,33,35,36,37) BRROKWAZCDMWEU-UHFFFAOYSA-N 444606 US10662186, Compound 153::US10988476, Compound I-153 Cyclin-dependent kinase 6 Homo sapiens 1.87 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444606&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196927 440706845 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028614 CN1CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)CC1 InChI=1S/C31H39F2N9/c1-20-35-29-23(32)16-22(17-26(29)42(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-7-6-21-19-41(9-8-25(21)36-27)15-14-40-12-10-39(5)11-13-40/h6-7,16-18H,8-15,19H2,1-5H3,(H,34,36,37,38) RHWIDIZNQRAAIU-UHFFFAOYSA-N 444607 US10662186, Compound 154::US10988476, Compound I-154 Cyclin-dependent kinase 6 Homo sapiens 1.97 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444607&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196899 440706846 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028617 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCP(C)(=O)CC4)CCc3n2)ncc1F InChI=1S/C31H39F2N8OP/c1-20-35-29-23(32)16-22(17-26(29)41(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-7-6-21-19-40(9-8-25(21)36-27)11-10-39-12-14-43(5,42)15-13-39/h6-7,16-18H,8-15,19H2,1-5H3,(H,34,36,37,38) WWPOWSOSERGQKM-UHFFFAOYSA-N 444608 US10662186, Compound 155::US10988476, Compound I-155 Cyclin-dependent kinase 6 Homo sapiens 2.08 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444608&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196893 440706847 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1028620 CN(CCO)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8O/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-7-6-19-17-38(9-8-23(19)34-25)11-10-37(5)12-13-40/h6-7,14-16,40H,8-13,17H2,1-5H3,(H,32,34,35,36) GIOKUJORFDKSSG-UHFFFAOYSA-N 444609 US10662186, Compound 157::US10988476, Compound I-157 Cyclin-dependent kinase 6 Homo sapiens 2.03 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444609&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 130196902 440706848 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51366798 NC(=O)c1sc(nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1)-c1ccnc(NC(=O)C2CC2)c1 InChI=1S/C28H32FN5O3S/c29-22-7-3-19(4-8-22)17-34-13-10-18(11-14-34)2-1-15-37-27-24(25(30)35)38-28(33-27)21-9-12-31-23(16-21)32-26(36)20-5-6-20/h3-4,7-9,12,16,18,20H,1-2,5-6,10-11,13-15,17H2,(H2,30,35)(H,31,32,36) LQLBWZJHRARWDB-UHFFFAOYSA-N 50552452 CHEMBL4747992 Cyclin-dependent kinase 6 Homo sapiens >300 ChEMBL 10.1016/j.bmc.2020.115940 10.7270/Q20K2D6W 33340937 Jiang, X; Wang, Y; Liu, C; Xing, C; Wang, Y; Lyu, W; Wang, S; Li, Q; Chen, T; Chen, Y; Feng, F; Liu, W; Sun, H China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552452&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156165678 461682792 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51368978 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 6 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51368979 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-dependent kinase 6 Homo sapiens 170 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51369050 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 167699 US9073922, 186::US9796708, Example 186 Cyclin-dependent kinase 6 Homo sapiens 298 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167699&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 90414175 312321544 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51369051 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 354126 US9796708, Example 1358::trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexanecarboxylic acid Cyclin-dependent kinase 6 Homo sapiens 101 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354126&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 90419627 386047858 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51358883 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-dependent kinase 6 Homo sapiens 363 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51358884 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(F)cn1 InChI=1S/C22H28FN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 JTIFUJUJDWUQEV-LSDHHAIUSA-N 454542 US10717746, Example 25::US10717746, Example 84 Cyclin-dependent kinase 6 Homo sapiens 532 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454542&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124155169 440970408 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51358885 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCc23)c(Cl)cn1 InChI=1S/C21H26ClN5O2/c1-13(28)25-15-6-4-5-14(9-15)21(29)26-20-10-16(18(22)12-23-20)17-11-24-27-8-3-2-7-19(17)27/h10-12,14-15H,2-9H2,1H3,(H,25,28)(H,23,26,29)/t14-,15+/m0/s1 AKIBGBJFUGFCIJ-LSDHHAIUSA-N 454519 US10717746, Example 2 Cyclin-dependent kinase 6 Homo sapiens 2500 ChEMBL 10.1021/acs.jmedchem.0c01754 10.7270/Q2M90D8V 33306391 Barlaam, B; Casella, R; Cidado, J; Cook, C; De Savi, C; Dishington, A; Donald, CS; Drew, L; Ferguson, AD; Ferguson, D; Glossop, S; Grebe, T; Gu, C; Hande, S; Hawkins, J; Hird, AW; Holmes, J; Horstick, J; Jiang, Y; Lamb, ML; McGuire, TM; Moore, JE; O'Connell, N; Pike, A; Pike, KG; Proia, T; Roberts, B; San Martin, M; Sarkar, U; Shao, W; Stead, D; Sumner, N; Thakur, K; Vasbinder, MM; Varnes, JG; Wang, J; Wang, L; Wu, D; Wu, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=454519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=454519&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 124155310 440970385 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111195 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H27F2N7O/c1-15(2)33-9-10-34-23-18(25)11-16(12-20(23)33)22-19(26)14-29-24(31-22)30-21-4-3-17(13-28-21)32-7-5-27-6-8-32/h3-4,11-15,27H,5-10H2,1-2H3,(H,28,29,30,31) ZRCBVOZDKPPBFL-UHFFFAOYSA-N 525562 US11174252, Compound 1 Cyclin-dependent kinase 6 Homo sapiens 0.200 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525562&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390054 463789217 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111199 CC(C)N1C(=O)COc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H25F2N7O2/c1-14(2)33-19-10-15(9-17(25)23(19)35-13-21(33)34)22-18(26)12-29-24(31-22)30-20-4-3-16(11-28-20)32-7-5-27-6-8-32/h3-4,9-12,14,27H,5-8,13H2,1-2H3,(H,28,29,30,31) FCWWBOZXMLGFHI-UHFFFAOYSA-N 525708 US11174252, Compound 2 Cyclin-dependent kinase 6 Homo sapiens 6.90 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525708&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390032 463789355 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111202 Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1cc(F)c2OCCNc2c1 InChI=1S/C21H21F2N7O/c22-15-9-13(10-17-20(15)31-8-5-25-17)19-16(23)12-27-21(29-19)28-18-2-1-14(11-26-18)30-6-3-24-4-7-30/h1-2,9-12,24-25H,3-8H2,(H,26,27,28,29) WADAAQHFKRCHPA-UHFFFAOYSA-N 525709 US11174252, Compound 3 Cyclin-dependent kinase 6 Homo sapiens 5.70 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525709&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390092 463789356 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111205 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4OCCN(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H33F2N7O/c1-4-34-7-9-35(10-8-34)17-19-5-6-24(30-15-19)32-27-31-16-22(29)25(33-27)20-13-21(28)26-23(14-20)36(18(2)3)11-12-37-26/h5-6,13-16,18H,4,7-12,17H2,1-3H3,(H,30,31,32,33) CJDWWOZYUHVICE-UHFFFAOYSA-N 525710 US11174252, Compound 4 Cyclin-dependent kinase 6 Homo sapiens 0.100 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525710&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390076 463789357 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111214 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4OCCN(C5CCC(N)CC5)c4c3)nc2)CC1 InChI=1S/C30H38F2N8O/c1-2-38-9-11-39(12-10-38)19-20-3-8-27(34-17-20)36-30-35-18-25(32)28(37-30)21-15-24(31)29-26(16-21)40(13-14-41-29)23-6-4-22(33)5-7-23/h3,8,15-18,22-23H,2,4-7,9-14,19,33H2,1H3,(H,34,35,36,37) HPPMQZMEMYJVOC-UHFFFAOYSA-N 525714 US11174252, Compound 9 Cyclin-dependent kinase 6 Homo sapiens 173 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525714&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390035 463789361 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111217 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCNC(C)C2)ncc1F InChI=1S/C25H29F2N7O/c1-15(2)34-8-9-35-24-19(26)10-17(11-21(24)34)23-20(27)13-30-25(32-23)31-22-5-4-18(12-29-22)33-7-6-28-16(3)14-33/h4-5,10-13,15-16,28H,6-9,14H2,1-3H3,(H,29,30,31,32) ANDYPXVQXOKMKT-UHFFFAOYSA-N 525715 US11174252, Compound 10 Cyclin-dependent kinase 6 Homo sapiens 2.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525715&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389987 463789362 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111220 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cc2F)N2CCNCC2)ncc1F InChI=1S/C25H27F3N6O/c1-15(2)34-9-10-35-24-19(27)11-16(12-22(24)34)23-20(28)14-30-25(32-23)31-21-4-3-17(13-18(21)26)33-7-5-29-6-8-33/h3-4,11-15,29H,5-10H2,1-2H3,(H,30,31,32) TZDIAPGMMCTLTB-UHFFFAOYSA-N 525716 US11174252, Compound 11 Cyclin-dependent kinase 6 Homo sapiens 8.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525716&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389998 463789363 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111223 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F InChI=1S/C25H27F3N6O/c1-15(2)34-9-10-35-24-19(27)11-16(12-22(24)34)23-20(28)14-30-25(32-23)31-17-3-4-21(18(26)13-17)33-7-5-29-6-8-33/h3-4,11-15,29H,5-10H2,1-2H3,(H,30,31,32) FLCBSMQHFJNBOM-UHFFFAOYSA-N 525717 US11174252, Compound 12 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525717&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390044 463789364 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111230 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3c2)ncc1F InChI=1S/C24H25F2N5O/c1-14(2)31-7-8-32-23-19(25)10-17(11-21(23)31)22-20(26)13-28-24(30-22)29-18-4-3-16-12-27-6-5-15(16)9-18/h3-4,9-11,13-14,27H,5-8,12H2,1-2H3,(H,28,29,30) FTWLELHFVFNVSG-UHFFFAOYSA-N 525718 US11174252, Compound 13 Cyclin-dependent kinase 6 Homo sapiens 1.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525718&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390012 463789365 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111233 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCN(C)CC3)c(F)c2)ncc1F InChI=1S/C26H29F3N6O/c1-16(2)35-10-11-36-25-20(28)12-17(13-23(25)35)24-21(29)15-30-26(32-24)31-18-4-5-22(19(27)14-18)34-8-6-33(3)7-9-34/h4-5,12-16H,6-11H2,1-3H3,(H,30,31,32) OWEQYKIYPQEPSQ-UHFFFAOYSA-N 525719 US11174252, Compound 14 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525719&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390248 463789366 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111236 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cccc3CNCCc23)ncc1F InChI=1S/C24H25F2N5O/c1-14(2)31-8-9-32-23-18(25)10-16(11-21(23)31)22-19(26)13-28-24(30-22)29-20-5-3-4-15-12-27-7-6-17(15)20/h3-5,10-11,13-14,27H,6-9,12H2,1-2H3,(H,28,29,30) PUHKAOLWMGXVFS-UHFFFAOYSA-N 525720 US11174252, Compound 15 Cyclin-dependent kinase 6 Homo sapiens 30.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525720&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390064 463789367 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111239 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CCNCc3c2)ncc1F InChI=1S/C24H25F2N5O/c1-14(2)31-7-8-32-23-19(25)10-16(11-21(23)31)22-20(26)13-28-24(30-22)29-18-4-3-15-5-6-27-12-17(15)9-18/h3-4,9-11,13-14,27H,5-8,12H2,1-2H3,(H,28,29,30) YWCKVLPHEKWBJP-UHFFFAOYSA-N 525721 US11174252, Compound 16 Cyclin-dependent kinase 6 Homo sapiens 1.000 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525721&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390174 463789368 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111242 CC(C)N1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)cc1F InChI=1S/C28H33F3N6O/c1-17(2)35-7-9-36(10-8-35)24-6-5-20(15-21(24)29)33-28-32-16-23(31)26(34-28)19-13-22(30)27-25(14-19)37(18(3)4)11-12-38-27/h5-6,13-18H,7-12H2,1-4H3,(H,32,33,34) GXXLEOJAXDGEGP-UHFFFAOYSA-N 525722 US11174252, Compound 17 Cyclin-dependent kinase 6 Homo sapiens 3.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525722&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390051 463789369 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111245 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCNCC3)c(F)c2)ncc1F InChI=1S/C26H28F3N5O/c1-15(2)34-9-10-35-25-21(28)11-17(12-23(25)34)24-22(29)14-31-26(33-24)32-18-3-4-19(20(27)13-18)16-5-7-30-8-6-16/h3-4,11-16,30H,5-10H2,1-2H3,(H,31,32,33) HOFGFUOFMADIHI-UHFFFAOYSA-N 525723 US11174252, Compound 18 Cyclin-dependent kinase 6 Homo sapiens 15.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525723&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390067 463789370 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111248 CC(C)N1CCc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4OCCN(C(C)C)c4c3)cc2C1 InChI=1S/C27H31F2N5O/c1-16(2)33-8-7-18-5-6-21(11-20(18)15-33)31-27-30-14-23(29)25(32-27)19-12-22(28)26-24(13-19)34(17(3)4)9-10-35-26/h5-6,11-14,16-17H,7-10,15H2,1-4H3,(H,30,31,32) VRIWWBXFSKWVDK-UHFFFAOYSA-N 525724 US11174252, Compound 19 Cyclin-dependent kinase 6 Homo sapiens 1.000 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525724&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390050 463789371 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111251 CC(C)N1CCc2c(C1)cccc2Nc1ncc(F)c(n1)-c1cc(F)c2OCCN(C(C)C)c2c1 InChI=1S/C27H31F2N5O/c1-16(2)33-9-8-20-18(15-33)6-5-7-23(20)31-27-30-14-22(29)25(32-27)19-12-21(28)26-24(13-19)34(17(3)4)10-11-35-26/h5-7,12-14,16-17H,8-11,15H2,1-4H3,(H,30,31,32) CQXYAWGSQLDRAK-UHFFFAOYSA-N 525725 US11174252, Compound 20 Cyclin-dependent kinase 6 Homo sapiens 187 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525725&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390045 463789372 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111254 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(c2)C#N)ncc1F InChI=1S/C26H27F2N7O/c1-16(2)35-9-10-36-25-20(27)12-17(13-23(25)35)24-21(28)15-31-26(33-24)32-19-3-4-22(18(11-19)14-29)34-7-5-30-6-8-34/h3-4,11-13,15-16,30H,5-10H2,1-2H3,(H,31,32,33) KYTOYNOCCLVCDI-UHFFFAOYSA-N 525726 US11174252, Compound 21 Cyclin-dependent kinase 6 Homo sapiens 8.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525726&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390118 463789373 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111257 CC(C)N1CCc2cc(Nc3ncc(F)c(n3)-c3cc(F)c4OCCN(C(C)C)c4c3)ccc2C1 InChI=1S/C27H31F2N5O/c1-16(2)33-8-7-18-11-21(6-5-19(18)15-33)31-27-30-14-23(29)25(32-27)20-12-22(28)26-24(13-20)34(17(3)4)9-10-35-26/h5-6,11-14,16-17H,7-10,15H2,1-4H3,(H,30,31,32) GMHSCMWFLYBPIU-UHFFFAOYSA-N 525727 US11174252, Compound 22 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525727&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390192 463789374 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111260 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nc2)N2CCNCC2)ncc1F InChI=1S/C24H27F2N7O/c1-15(2)33-9-10-34-23-18(25)11-16(12-20(23)33)22-19(26)14-29-24(31-22)30-17-3-4-21(28-13-17)32-7-5-27-6-8-32/h3-4,11-15,27H,5-10H2,1-2H3,(H,29,30,31) BPMAUJVZZZYXDV-UHFFFAOYSA-N 525728 US11174252, Compound 23 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525728&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390086 463789375 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111264 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(C)CC3)c(F)c2)ncc1F InChI=1S/C27H30F3N5O/c1-16(2)35-10-11-36-26-22(29)12-18(13-24(26)35)25-23(30)15-31-27(33-25)32-19-4-5-20(21(28)14-19)17-6-8-34(3)9-7-17/h4-5,12-17H,6-11H2,1-3H3,(H,31,32,33) DZKMAWNYSJECKX-UHFFFAOYSA-N 525729 US11174252, Compound 24 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525729&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390111 463789376 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111273 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCC(CC3)N(C)C)c(F)c2)ncc1F InChI=1S/C28H33F3N6O/c1-17(2)37-11-12-38-27-22(30)13-18(14-25(27)37)26-23(31)16-32-28(34-26)33-19-5-6-24(21(29)15-19)36-9-7-20(8-10-36)35(3)4/h5-6,13-17,20H,7-12H2,1-4H3,(H,32,33,34) LSBJWBSFOYFELK-UHFFFAOYSA-N 525730 US11174252, Compound 25 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525730&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390154 463789377 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111282 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCOCC3)c(F)c2)ncc1F InChI=1S/C25H26F3N5O2/c1-15(2)33-7-10-35-24-19(27)11-16(12-22(24)33)23-20(28)14-29-25(31-23)30-17-3-4-21(18(26)13-17)32-5-8-34-9-6-32/h3-4,11-15H,5-10H2,1-2H3,(H,29,30,31) KCNLVQFEDCQFPU-UHFFFAOYSA-N 525731 US11174252, Compound 26 Cyclin-dependent kinase 6 Homo sapiens 134 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525731&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390225 463789378 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111285 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCC(CC3)N3CCCC3)c(F)c2)ncc1F InChI=1S/C30H35F3N6O/c1-19(2)39-13-14-40-29-24(32)15-20(16-27(29)39)28-25(33)18-34-30(36-28)35-21-5-6-26(23(31)17-21)38-11-7-22(8-12-38)37-9-3-4-10-37/h5-6,15-19,22H,3-4,7-14H2,1-2H3,(H,34,35,36) SKATULOGJADMCI-UHFFFAOYSA-N 525732 US11174252, Compound 27 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525732&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139409607 463789379 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111288 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2F)ncc1F InChI=1S/C25H26F4N6O/c1-14(2)35-9-10-36-24-16(26)11-15(12-20(24)35)23-17(27)13-31-25(33-23)32-18-3-4-19(22(29)21(18)28)34-7-5-30-6-8-34/h3-4,11-14,30H,5-10H2,1-2H3,(H,31,32,33) MIZFTGLHDNPPOW-UHFFFAOYSA-N 525733 US11174252, Compound 28 Cyclin-dependent kinase 6 Homo sapiens 11.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525733&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390155 463789380 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111291 COc1cc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)ccc1N1CCNCC1 InChI=1S/C26H30F2N6O2/c1-16(2)34-10-11-36-25-19(27)12-17(13-22(25)34)24-20(28)15-30-26(32-24)31-18-4-5-21(23(14-18)35-3)33-8-6-29-7-9-33/h4-5,12-16,29H,6-11H2,1-3H3,(H,30,31,32) XLQVSVGFKKDHDL-UHFFFAOYSA-N 525734 US11174252, Compound 29 Cyclin-dependent kinase 6 Homo sapiens 13.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525734&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390147 463789381 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111294 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1Cl InChI=1S/C25H27ClF2N6O/c1-15(2)34-9-10-35-24-20(28)11-16(12-22(24)34)23-18(26)14-30-25(32-23)31-17-3-4-21(19(27)13-17)33-7-5-29-6-8-33/h3-4,11-15,29H,5-10H2,1-2H3,(H,30,31,32) GWEDWMIAAOCAQD-UHFFFAOYSA-N 525735 US11174252, Compound 30 Cyclin-dependent kinase 6 Homo sapiens 13.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525735&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390260 463789382 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111297 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cc(F)c(cc2F)N2CCNCC2)ncc1F InChI=1S/C25H26F4N6O/c1-14(2)35-7-8-36-24-18(28)9-15(10-22(24)35)23-19(29)13-31-25(33-23)32-20-11-17(27)21(12-16(20)26)34-5-3-30-4-6-34/h9-14,30H,3-8H2,1-2H3,(H,31,32,33) UQVXBLAVQKBUCD-UHFFFAOYSA-N 525736 US11174252, Compound 31 Cyclin-dependent kinase 6 Homo sapiens 32.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525736&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390272 463789383 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111300 CC(C)N1CC(C)Oc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F InChI=1S/C26H29F3N6O/c1-15(2)35-14-16(3)36-25-20(28)10-17(11-23(25)35)24-21(29)13-31-26(33-24)32-18-4-5-22(19(27)12-18)34-8-6-30-7-9-34/h4-5,10-13,15-16,30H,6-9,14H2,1-3H3,(H,31,32,33) QHWCDWDOTQYDCS-UHFFFAOYSA-N 525737 US11174252, Compound 32 Cyclin-dependent kinase 6 Homo sapiens 21.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525737&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390003 463789384 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111303 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nc2)C2CCN(C)CC2)ncc1F InChI=1S/C26H30F2N6O/c1-16(2)34-10-11-35-25-20(27)12-18(13-23(25)34)24-21(28)15-30-26(32-24)31-19-4-5-22(29-14-19)17-6-8-33(3)9-7-17/h4-5,12-17H,6-11H2,1-3H3,(H,30,31,32) BRBJCJHJBAMBPR-UHFFFAOYSA-N 525738 US11174252, Compound 33 Cyclin-dependent kinase 6 Homo sapiens 1.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525738&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390102 463789385 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111311 CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F InChI=1S/C23H23F3N6O/c1-31-8-9-33-22-17(25)10-14(11-20(22)31)21-18(26)13-28-23(30-21)29-15-2-3-19(16(24)12-15)32-6-4-27-5-7-32/h2-3,10-13,27H,4-9H2,1H3,(H,28,29,30) ZXZSDNZHOPWUFI-UHFFFAOYSA-N 525739 US11174252, Compound 34 Cyclin-dependent kinase 6 Homo sapiens 6.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525739&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390107 463789386 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111314 CCN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F InChI=1S/C24H25F3N6O/c1-2-32-9-10-34-23-18(26)11-15(12-21(23)32)22-19(27)14-29-24(31-22)30-16-3-4-20(17(25)13-16)33-7-5-28-6-8-33/h3-4,11-14,28H,2,5-10H2,1H3,(H,29,30,31) UZYBVBHFAVVOGH-UHFFFAOYSA-N 525740 US11174252, Compound 35 Cyclin-dependent kinase 6 Homo sapiens 3.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525740&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390119 463789387 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111317 CCCN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F InChI=1S/C25H27F3N6O/c1-2-7-33-10-11-35-24-19(27)12-16(13-22(24)33)23-20(28)15-30-25(32-23)31-17-3-4-21(18(26)14-17)34-8-5-29-6-9-34/h3-4,12-15,29H,2,5-11H2,1H3,(H,30,31,32) XTFZDJWRYNEFRC-UHFFFAOYSA-N 525741 US11174252, Compound 36 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525741&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390096 463789388 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111320 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CC(Cc3c2)N(C)C)ncc1F InChI=1S/C26H29F2N5O/c1-15(2)33-7-8-34-25-21(27)12-18(13-23(25)33)24-22(28)14-29-26(31-24)30-19-6-5-16-10-20(32(3)4)11-17(16)9-19/h5-6,9,12-15,20H,7-8,10-11H2,1-4H3,(H,29,30,31) BLBRCCGITKEOBW-UHFFFAOYSA-N 525742 US11174252, Compound 37 Cyclin-dependent kinase 6 Homo sapiens 3.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525742&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389969 463789389 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111323 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nc2)N2CCC(CC2)N(C)C)ncc1F InChI=1S/C27H33F2N7O/c1-17(2)36-11-12-37-26-21(28)13-18(14-23(26)36)25-22(29)16-31-27(33-25)32-19-5-6-24(30-15-19)35-9-7-20(8-10-35)34(3)4/h5-6,13-17,20H,7-12H2,1-4H3,(H,31,32,33) YGZQAQIWZFMADC-UHFFFAOYSA-N 525743 US11174252, Compound 38 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525743&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390224 463789390 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111331 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccn(C3=CCNCC3)c(=O)c2)ncc1F InChI=1S/C25H26F2N6O2/c1-15(2)32-9-10-35-24-19(26)11-16(12-21(24)32)23-20(27)14-29-25(31-23)30-17-5-8-33(22(34)13-17)18-3-6-28-7-4-18/h3,5,8,11-15,28H,4,6-7,9-10H2,1-2H3,(H,29,30,31) PJJRCQULLSOBAU-UHFFFAOYSA-N 525744 US11174252, Compound 39 Cyclin-dependent kinase 6 Homo sapiens 7.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525744&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390161 463789391 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111334 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CC(CCc3c2)N(C)C)ncc1F InChI=1S/C27H31F2N5O/c1-16(2)34-9-10-35-26-22(28)13-19(14-24(26)34)25-23(29)15-30-27(32-25)31-20-7-5-18-12-21(33(3)4)8-6-17(18)11-20/h5,7,11,13-16,21H,6,8-10,12H2,1-4H3,(H,30,31,32) YEQZZLYGLQFEAM-UHFFFAOYSA-N 525745 US11174252, Compound 47 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525745&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390195 463789392 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111337 CC(C)N1CCOc2c(Cl)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1Cl InChI=1S/C25H27Cl2FN6O/c1-15(2)34-9-10-35-24-18(26)11-16(12-22(24)34)23-19(27)14-30-25(32-23)31-17-3-4-21(20(28)13-17)33-7-5-29-6-8-33/h3-4,11-15,29H,5-10H2,1-2H3,(H,30,31,32) GTSSIJGMGBRKKN-UHFFFAOYSA-N 525746 US11174252, Compound 52 Cyclin-dependent kinase 6 Homo sapiens 200 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525746&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389983 463789393 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111340 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCC(CC3)N(C)C)c(c2)C(F)(F)F)ncc1F InChI=1S/C29H33F5N6O/c1-17(2)40-11-12-41-27-22(30)13-18(14-25(27)40)26-23(31)16-35-28(37-26)36-19-5-6-24(21(15-19)29(32,33)34)39-9-7-20(8-10-39)38(3)4/h5-6,13-17,20H,7-12H2,1-4H3,(H,35,36,37) DXMFQSGVYNUHAF-UHFFFAOYSA-N 525747 US11174252, Compound 178 Cyclin-dependent kinase 6 Homo sapiens 98.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525747&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390233 463789394 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111343 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CCC(Cc3c2)N(C)C)ncc1F InChI=1S/C27H31F2N5O/c1-16(2)34-9-10-35-26-22(28)13-19(14-24(26)34)25-23(29)15-30-27(32-25)31-20-7-5-17-6-8-21(33(3)4)12-18(17)11-20/h5,7,11,13-16,21H,6,8-10,12H2,1-4H3,(H,30,31,32) FHMFHOQHUFKWBK-UHFFFAOYSA-N 525748 US11174252, Compound 206 Cyclin-dependent kinase 6 Homo sapiens 100.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525748&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390171 463789395 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111346 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)ncc1F InChI=1S/C27H33F2N7O/c1-17(2)36-11-12-37-26-21(28)13-18(14-23(26)36)25-22(29)16-31-27(33-25)32-24-6-5-20(15-30-24)35-9-7-19(8-10-35)34(3)4/h5-6,13-17,19H,7-12H2,1-4H3,(H,30,31,32,33) HCEVZIBGQRWFCG-UHFFFAOYSA-N 525749 US11174252, Compound 436 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525749&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390214 463789396 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111354 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccn(C3CCNCC3)c(=O)c2)ncc1F InChI=1S/C25H28F2N6O2/c1-15(2)32-9-10-35-24-19(26)11-16(12-21(24)32)23-20(27)14-29-25(31-23)30-17-5-8-33(22(34)13-17)18-3-6-28-7-4-18/h5,8,11-15,18,28H,3-4,6-7,9-10H2,1-2H3,(H,29,30,31) UPQKBKLECVIXJR-UHFFFAOYSA-N 525750 US11174252, Compound 437 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525750&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390031 463789397 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111362 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCNCC3)c(c2)C(F)(F)F)ncc1F InChI=1S/C27H28F5N5O/c1-15(2)37-9-10-38-25-21(28)11-17(12-23(25)37)24-22(29)14-34-26(36-24)35-18-3-4-19(16-5-7-33-8-6-16)20(13-18)27(30,31)32/h3-4,11-16,33H,5-10H2,1-2H3,(H,34,35,36) POVOYMIAJXXYSA-UHFFFAOYSA-N 525751 US11174252, Compound 438 Cyclin-dependent kinase 6 Homo sapiens 74.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525751&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390287 463789398 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111365 CC(C)N1CCOc2c(Cl)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F InChI=1S/C25H27ClF2N6O/c1-15(2)34-9-10-35-24-18(26)11-16(12-22(24)34)23-20(28)14-30-25(32-23)31-17-3-4-21(19(27)13-17)33-7-5-29-6-8-33/h3-4,11-15,29H,5-10H2,1-2H3,(H,30,31,32) RHWSILDHCUHQSO-UHFFFAOYSA-N 525752 US11174252, Compound 439 Cyclin-dependent kinase 6 Homo sapiens 20.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525752&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390242 463789399 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111368 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cc2)N2CCN(CC2)C(=O)CN(C)C)ncc1F InChI=1S/C29H35F2N7O2/c1-19(2)38-13-14-40-28-23(30)15-20(16-25(28)38)27-24(31)17-32-29(34-27)33-21-5-7-22(8-6-21)36-9-11-37(12-10-36)26(39)18-35(3)4/h5-8,15-17,19H,9-14,18H2,1-4H3,(H,32,33,34) RQJDBRPTCFHLBI-UHFFFAOYSA-N 525753 US11174252, Compound 440 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525753&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390254 463789400 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111372 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)CN(C)C)ncc1F InChI=1S/C28H34F2N8O2/c1-18(2)38-11-12-40-27-21(29)13-19(14-23(27)38)26-22(30)16-32-28(34-26)33-24-6-5-20(15-31-24)36-7-9-37(10-8-36)25(39)17-35(3)4/h5-6,13-16,18H,7-12,17H2,1-4H3,(H,31,32,33,34) YCOFHJMLYTXYAJ-UHFFFAOYSA-N 525754 US11174252, Compound 441 Cyclin-dependent kinase 6 Homo sapiens 0.600 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525754&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390020 463789401 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111376 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(C)CC2)ncc1F InChI=1S/C26H30F2N6O/c1-16(2)34-10-11-35-25-20(27)12-19(13-22(25)34)24-21(28)15-30-26(32-24)31-23-5-4-18(14-29-23)17-6-8-33(3)9-7-17/h4-5,12-17H,6-11H2,1-3H3,(H,29,30,31,32) YZSCPLGKKMSBMV-UHFFFAOYSA-N 525755 US11174252, Compound 442 Cyclin-dependent kinase 6 Homo sapiens 1.000 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525755&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390026 463789402 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111385 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cc(F)c(cn2)C2CCNCC2)ncc1F InChI=1S/C25H27F3N6O/c1-14(2)34-7-8-35-24-19(27)9-16(10-21(24)34)23-20(28)13-31-25(33-23)32-22-11-18(26)17(12-30-22)15-3-5-29-6-4-15/h9-15,29H,3-8H2,1-2H3,(H,30,31,32,33) RLWUWLYKPWQOFL-UHFFFAOYSA-N 525756 US11174252, Compound 443 Cyclin-dependent kinase 6 Homo sapiens 3.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525756&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389999 463789403 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111389 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cc3CN(C)CCn3n2)ncc1F InChI=1S/C22H25F2N7O/c1-13(2)30-6-7-32-21-16(23)8-14(9-18(21)30)20-17(24)11-25-22(27-20)26-19-10-15-12-29(3)4-5-31(15)28-19/h8-11,13H,4-7,12H2,1-3H3,(H,25,26,27,28) SLORTXJSOVPUPP-UHFFFAOYSA-N 525757 US11174252, Compound 444 Cyclin-dependent kinase 6 Homo sapiens 3.40 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525757&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390288 463789404 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111393 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCC(O)CC3)c(F)c2)ncc1F InChI=1S/C26H28F3N5O2/c1-15(2)34-9-10-36-25-20(28)11-16(12-23(25)34)24-21(29)14-30-26(32-24)31-17-3-4-22(19(27)13-17)33-7-5-18(35)6-8-33/h3-4,11-15,18,35H,5-10H2,1-2H3,(H,30,31,32) KVLNOSOQLVFWOU-UHFFFAOYSA-N 525758 US11174252, Compound 445 Cyclin-dependent kinase 6 Homo sapiens 69.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525758&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390075 463789405 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111397 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCOCC2)ncc1F InChI=1S/C24H26F2N6O2/c1-15(2)32-7-10-34-23-18(25)11-16(12-20(23)32)22-19(26)14-28-24(30-22)29-21-4-3-17(13-27-21)31-5-8-33-9-6-31/h3-4,11-15H,5-10H2,1-2H3,(H,27,28,29,30) MDSUHMLXNPZZHO-UHFFFAOYSA-N 525759 US11174252, Compound 446 Cyclin-dependent kinase 6 Homo sapiens 8.80 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525759&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390009 463789406 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111405 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(O)CC2)ncc1F InChI=1S/C25H28F2N6O2/c1-15(2)33-9-10-35-24-19(26)11-16(12-21(24)33)23-20(27)14-29-25(31-23)30-22-4-3-17(13-28-22)32-7-5-18(34)6-8-32/h3-4,11-15,18,34H,5-10H2,1-2H3,(H,28,29,30,31) XSAQISWEGTUJBT-UHFFFAOYSA-N 525760 US11174252, Compound 447 Cyclin-dependent kinase 6 Homo sapiens 1.60 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525760&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390011 463789407 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111413 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cnn(c2)C2CCNCC2)ncc1F InChI=1S/C23H27F2N7O/c1-14(2)31-7-8-33-22-18(24)9-15(10-20(22)31)21-19(25)12-27-23(30-21)29-16-11-28-32(13-16)17-3-5-26-6-4-17/h9-14,17,26H,3-8H2,1-2H3,(H,27,29,30) GMUVHXBIPOWLCK-UHFFFAOYSA-N 525761 US11174252, Compound 448 Cyclin-dependent kinase 6 Homo sapiens 8.80 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525761&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390268 463789408 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111417 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCN(CC3)C(=O)CN(C)C)c(F)c2)ncc1F InChI=1S/C29H34F3N7O2/c1-18(2)39-11-12-41-28-22(31)13-19(14-25(28)39)27-23(32)16-33-29(35-27)34-20-5-6-24(21(30)15-20)37-7-9-38(10-8-37)26(40)17-36(3)4/h5-6,13-16,18H,7-12,17H2,1-4H3,(H,33,34,35) XOTKKGVUZBZUEX-UHFFFAOYSA-N 525762 US11174252, Compound 449 Cyclin-dependent kinase 6 Homo sapiens 0.900 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525762&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390291 463789409 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111421 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(CC2)C(=O)CN(C)C)ncc1F InChI=1S/C29H35F2N7O2/c1-18(2)38-11-12-40-28-22(30)13-21(14-24(28)38)27-23(31)16-33-29(35-27)34-25-6-5-20(15-32-25)19-7-9-37(10-8-19)26(39)17-36(3)4/h5-6,13-16,18-19H,7-12,17H2,1-4H3,(H,32,33,34,35) LFQCICBMIDNCDI-UHFFFAOYSA-N 525763 US11174252, Compound 450 Cyclin-dependent kinase 6 Homo sapiens 0.300 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525763&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390238 463789410 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111425 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(CC3)C(=O)CN(C)C)c(F)c2)ncc1F InChI=1S/C30H35F3N6O2/c1-18(2)39-11-12-41-29-24(32)13-20(14-26(29)39)28-25(33)16-34-30(36-28)35-21-5-6-22(23(31)15-21)19-7-9-38(10-8-19)27(40)17-37(3)4/h5-6,13-16,18-19H,7-12,17H2,1-4H3,(H,34,35,36) AZBVCCPKEJNWJE-UHFFFAOYSA-N 525764 US11174252, Compound 451 Cyclin-dependent kinase 6 Homo sapiens 27.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525764&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390016 463789411 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111429 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cnn(c2)C2CCC(O)CC2)ncc1F InChI=1S/C24H28F2N6O2/c1-14(2)31-7-8-34-23-19(25)9-15(10-21(23)31)22-20(26)12-27-24(30-22)29-16-11-28-32(13-16)17-3-5-18(33)6-4-17/h9-14,17-18,33H,3-8H2,1-2H3,(H,27,29,30) TTZAURANQVEMPE-UHFFFAOYSA-N 525765 US11174252, Compound 452 Cyclin-dependent kinase 6 Homo sapiens 45.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525765&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390087 463789412 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111433 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)N(C)C)ncc1F InChI=1S/C27H32F2N8O2/c1-17(2)37-11-12-39-25-20(28)13-18(14-22(25)37)24-21(29)16-31-26(33-24)32-23-6-5-19(15-30-23)35-7-9-36(10-8-35)27(38)34(3)4/h5-6,13-17H,7-12H2,1-4H3,(H,30,31,32,33) DFRLATSJZFEZJT-UHFFFAOYSA-N 525766 US11174252, Compound 453 Cyclin-dependent kinase 6 Homo sapiens 30.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525766&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390057 463789413 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111437 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(CC2)C(=O)N(C)C)ncc1F InChI=1S/C28H33F2N7O2/c1-17(2)37-11-12-39-26-21(29)13-20(14-23(26)37)25-22(30)16-32-27(34-25)33-24-6-5-19(15-31-24)18-7-9-36(10-8-18)28(38)35(3)4/h5-6,13-18H,7-12H2,1-4H3,(H,31,32,33,34) JXKYPLVWZPUCOD-UHFFFAOYSA-N 525767 US11174252, Compound 454 Cyclin-dependent kinase 6 Homo sapiens 83.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525767&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390176 463789414 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111441 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CCN(Cc3c2)C(=O)CN(C)C)ncc1F InChI=1S/C28H32F2N6O2/c1-17(2)36-9-10-38-27-22(29)12-19(13-24(27)36)26-23(30)14-31-28(33-26)32-21-6-5-18-7-8-35(15-20(18)11-21)25(37)16-34(3)4/h5-6,11-14,17H,7-10,15-16H2,1-4H3,(H,31,32,33) AYTDCXHHGYDWLU-UHFFFAOYSA-N 525768 US11174252, Compound 455 Cyclin-dependent kinase 6 Homo sapiens 3.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525768&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390022 463789415 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111445 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3c2)C(=O)CN(C)C)ncc1F InChI=1S/C28H32F2N6O2/c1-17(2)36-9-10-38-27-22(29)12-20(13-24(27)36)26-23(30)14-31-28(33-26)32-21-6-5-19-15-35(8-7-18(19)11-21)25(37)16-34(3)4/h5-6,11-14,17H,7-10,15-16H2,1-4H3,(H,31,32,33) JAMUFNNBMXMUIC-UHFFFAOYSA-N 525769 US11174252, Compound 456 Cyclin-dependent kinase 6 Homo sapiens 3.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525769&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390068 463789416 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111451 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C(=O)N3CCOCC3)c(F)c2)ncc1F InChI=1S/C26H26F3N5O3/c1-15(2)34-7-10-37-24-20(28)11-16(12-22(24)34)23-21(29)14-30-26(32-23)31-17-3-4-18(19(27)13-17)25(35)33-5-8-36-9-6-33/h3-4,11-15H,5-10H2,1-2H3,(H,30,31,32) OIHTZDBVUWNXKY-UHFFFAOYSA-N 525770 US11174252, Compound 457 Cyclin-dependent kinase 6 Homo sapiens 7.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525770&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390046 463789417 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111454 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C(=O)N3CCC(O)CC3)c(F)c2)ncc1F InChI=1S/C27H28F3N5O3/c1-15(2)35-9-10-38-25-21(29)11-16(12-23(25)35)24-22(30)14-31-27(33-24)32-17-3-4-19(20(28)13-17)26(37)34-7-5-18(36)6-8-34/h3-4,11-15,18,36H,5-10H2,1-2H3,(H,31,32,33) YZJYUACRMOFFJC-UHFFFAOYSA-N 525771 US11174252, Compound 458 Cyclin-dependent kinase 6 Homo sapiens 10.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525771&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390282 463789418 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111457 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C(=O)N2CCC(O)CC2)ncc1F InChI=1S/C26H28F2N6O3/c1-15(2)34-9-10-37-24-19(27)11-17(12-21(24)34)23-20(28)14-30-26(32-23)31-22-4-3-16(13-29-22)25(36)33-7-5-18(35)6-8-33/h3-4,11-15,18,35H,5-10H2,1-2H3,(H,29,30,31,32) PDKHLRDTPMNOGO-UHFFFAOYSA-N 525772 US11174252, Compound 460 Cyclin-dependent kinase 6 Homo sapiens 18.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525772&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390163 463789419 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111460 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4OCCN(C(C)C)c4c3)cc2F)CC1 InChI=1S/C28H33F3N6O/c1-4-35-7-9-36(10-8-35)17-19-5-6-21(15-22(19)29)33-28-32-16-24(31)26(34-28)20-13-23(30)27-25(14-20)37(18(2)3)11-12-38-27/h5-6,13-16,18H,4,7-12,17H2,1-3H3,(H,32,33,34) NGYRNPFGDZALOR-UHFFFAOYSA-N 525773 US11174252, Compound 461 Cyclin-dependent kinase 6 Homo sapiens 9.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525773&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390047 463789420 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111463 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(CN3CCC(CC3)N(C)C)c(F)c2)ncc1F InChI=1S/C29H35F3N6O/c1-18(2)38-11-12-39-28-24(31)13-20(14-26(28)38)27-25(32)16-33-29(35-27)34-21-6-5-19(23(30)15-21)17-37-9-7-22(8-10-37)36(3)4/h5-6,13-16,18,22H,7-12,17H2,1-4H3,(H,33,34,35) ITDDDMFXMSWPBU-UHFFFAOYSA-N 525774 US11174252, Compound 462 Cyclin-dependent kinase 6 Homo sapiens 9.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525774&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390052 463789421 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111466 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C(=O)N3CCC(CC3)N(C)C)c(F)c2)ncc1F InChI=1S/C29H33F3N6O2/c1-17(2)38-11-12-40-27-23(31)13-18(14-25(27)38)26-24(32)16-33-29(35-26)34-19-5-6-21(22(30)15-19)28(39)37-9-7-20(8-10-37)36(3)4/h5-6,13-17,20H,7-12H2,1-4H3,(H,33,34,35) FHEQFUUMLHFZOS-UHFFFAOYSA-N 525775 US11174252, Compound 463 Cyclin-dependent kinase 6 Homo sapiens 3.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525775&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390006 463789422 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111469 CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)cc1F InChI=1S/C28H31F3N6O2/c1-4-35-7-9-36(10-8-35)27(38)20-6-5-19(15-21(20)29)33-28-32-16-23(31)25(34-28)18-13-22(30)26-24(14-18)37(17(2)3)11-12-39-26/h5-6,13-17H,4,7-12H2,1-3H3,(H,32,33,34) HFDVXFHTDRHDGR-UHFFFAOYSA-N 525776 US11174252, Compound 464 Cyclin-dependent kinase 6 Homo sapiens 22.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525776&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390223 463789423 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111472 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCS(=O)(=O)CC3)c(F)c2)ncc1F InChI=1S/C25H26F3N5O3S/c1-15(2)33-5-8-36-24-19(27)11-16(12-22(24)33)23-20(28)14-29-25(31-23)30-17-3-4-21(18(26)13-17)32-6-9-37(34,35)10-7-32/h3-4,11-15H,5-10H2,1-2H3,(H,29,30,31) UOIWOLQCAHYVMX-UHFFFAOYSA-N 525777 US11174252, Compound 465 Cyclin-dependent kinase 6 Homo sapiens 123 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525777&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390104 463789424 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111476 CN1CCC(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C)c3c2)cc1F InChI=1S/C25H26F3N5O/c1-32-7-5-15(6-8-32)18-4-3-17(13-19(18)26)30-25-29-14-21(28)23(31-25)16-11-20(27)24-22(12-16)33(2)9-10-34-24/h3-4,11-15H,5-10H2,1-2H3,(H,29,30,31) STCYCBYVGGLOHC-UHFFFAOYSA-N 525778 US11174252, Compound 466 Cyclin-dependent kinase 6 Homo sapiens 10.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525778&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390145 463789425 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111480 CN(C)C1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C)c3c2)cc1F InChI=1S/C26H29F3N6O/c1-33(2)18-6-8-35(9-7-18)22-5-4-17(14-19(22)27)31-26-30-15-21(29)24(32-26)16-12-20(28)25-23(13-16)34(3)10-11-36-25/h4-5,12-15,18H,6-11H2,1-3H3,(H,30,31,32) BOBVHORYEBZACZ-UHFFFAOYSA-N 525779 US11174252, Compound 467 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525779&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390128 463789426 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111484 CCCN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCC(CC3)N(C)C)c(F)c2)ncc1F InChI=1S/C28H33F3N6O/c1-4-9-36-12-13-38-27-22(30)14-18(15-25(27)36)26-23(31)17-32-28(34-26)33-19-5-6-24(21(29)16-19)37-10-7-20(8-11-37)35(2)3/h5-6,14-17,20H,4,7-13H2,1-3H3,(H,32,33,34) NUEMVFMYWAEICC-UHFFFAOYSA-N 525780 US11174252, Compound 468 Cyclin-dependent kinase 6 Homo sapiens 8.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525780&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390121 463789427 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111488 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCSCC3)c(F)c2)ncc1F InChI=1S/C25H26F3N5OS/c1-15(2)33-5-8-34-24-19(27)11-16(12-22(24)33)23-20(28)14-29-25(31-23)30-17-3-4-21(18(26)13-17)32-6-9-35-10-7-32/h3-4,11-15H,5-10H2,1-2H3,(H,29,30,31) XOWBYADIWSUVKJ-UHFFFAOYSA-N 525781 US11174252, Compound 469 Cyclin-dependent kinase 6 Homo sapiens 200 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525781&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390170 463789428 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111492 CN(C)C1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C4CCCC4)c3c2)cc1F InChI=1S/C30H35F3N6O/c1-37(2)21-9-11-38(12-10-21)26-8-7-20(17-23(26)31)35-30-34-18-25(33)28(36-30)19-15-24(32)29-27(16-19)39(13-14-40-29)22-5-3-4-6-22/h7-8,15-18,21-22H,3-6,9-14H2,1-2H3,(H,34,35,36) MECOEGINTAWKRY-UHFFFAOYSA-N 525782 US11174252, Compound 470 Cyclin-dependent kinase 6 Homo sapiens 19.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525782&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390010 463789429 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111496 CN1CCC(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C4CCCC4)c3c2)cc1F InChI=1S/C29H32F3N5O/c1-36-10-8-18(9-11-36)22-7-6-20(16-23(22)30)34-29-33-17-25(32)27(35-29)19-14-24(31)28-26(15-19)37(12-13-38-28)21-4-2-3-5-21/h6-7,14-18,21H,2-5,8-13H2,1H3,(H,33,34,35) AUARWWSRHMPTLW-UHFFFAOYSA-N 525783 US11174252, Compound 471 Cyclin-dependent kinase 6 Homo sapiens 53.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525783&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390129 463789430 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111500 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(C)CC2=O)ncc1F InChI=1S/C26H28F2N6O2/c1-15(2)34-8-9-36-25-19(27)10-17(11-21(25)34)24-20(28)13-30-26(32-24)31-23-5-4-16(12-29-23)18-6-7-33(3)14-22(18)35/h4-5,10-13,15,18H,6-9,14H2,1-3H3,(H,29,30,31,32) ORANZZBUKCNAKJ-UHFFFAOYSA-N 525784 US11174252, Compound 472 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525784&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139410423 463789431 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111503 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCN4CCCC4C3)c(F)c2)ncc1F InChI=1S/C28H31F3N6O/c1-17(2)37-10-11-38-27-22(30)12-18(13-25(27)37)26-23(31)15-32-28(34-26)33-19-5-6-24(21(29)14-19)36-9-8-35-7-3-4-20(35)16-36/h5-6,12-15,17,20H,3-4,7-11,16H2,1-2H3,(H,32,33,34) OUEDGCGXKXFPMQ-UHFFFAOYSA-N 525785 US11174252, Compound 473 Cyclin-dependent kinase 6 Homo sapiens 105 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525785&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390182 463789432 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111507 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(C)=O)ncc1F InChI=1S/C26H29F2N7O2/c1-16(2)35-10-11-37-25-20(27)12-18(13-22(25)35)24-21(28)15-30-26(32-24)31-23-5-4-19(14-29-23)34-8-6-33(7-9-34)17(3)36/h4-5,12-16H,6-11H2,1-3H3,(H,29,30,31,32) YNRGKDBIZBNELI-UHFFFAOYSA-N 525786 US11174252, Compound 474 Cyclin-dependent kinase 6 Homo sapiens 4.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525786&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390056 463789433 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111511 CC(C)CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(C)CC3)c(F)c2)ncc1F InChI=1S/C28H32F3N5O/c1-17(2)16-36-10-11-37-27-23(30)12-19(13-25(27)36)26-24(31)15-32-28(34-26)33-20-4-5-21(22(29)14-20)18-6-8-35(3)9-7-18/h4-5,12-15,17-18H,6-11,16H2,1-3H3,(H,32,33,34) YOZIUASNGGMFQI-UHFFFAOYSA-N 525787 US11174252, Compound 476 Cyclin-dependent kinase 6 Homo sapiens 25.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525787&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390178 463789434 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111515 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCCNCC2)ncc1F InChI=1S/C25H29F2N7O/c1-16(2)34-10-11-35-24-19(26)12-17(13-21(24)34)23-20(27)15-30-25(32-23)31-22-5-4-18(14-29-22)33-8-3-6-28-7-9-33/h4-5,12-16,28H,3,6-11H2,1-2H3,(H,29,30,31,32) NJXVAAHYUFZELV-UHFFFAOYSA-N 525788 US11174252, Compound 477 Cyclin-dependent kinase 6 Homo sapiens 4.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525788&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390133 463789435 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111521 Fc1cnc(Nc2ccc(cn2)N2CCCNCC2)nc1-c1cc(F)c2OCCN(C3CCCC3)c2c1 InChI=1S/C27H31F2N7O/c28-21-14-18(15-23-26(21)37-13-12-36(23)19-4-1-2-5-19)25-22(29)17-32-27(34-25)33-24-7-6-20(16-31-24)35-10-3-8-30-9-11-35/h6-7,14-17,19,30H,1-5,8-13H2,(H,31,32,33,34) UJCYGTTWTLTIEZ-UHFFFAOYSA-N 525789 US11174252, Compound 478 Cyclin-dependent kinase 6 Homo sapiens 27.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525789&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390126 463789436 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111527 CC(C)CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(C)CC2)ncc1F InChI=1S/C27H32F2N6O/c1-17(2)16-35-10-11-36-26-21(28)12-20(13-23(26)35)25-22(29)15-31-27(33-25)32-24-5-4-19(14-30-24)18-6-8-34(3)9-7-18/h4-5,12-15,17-18H,6-11,16H2,1-3H3,(H,30,31,32,33) LEKYSYXNVDOBCA-UHFFFAOYSA-N 525790 US11174252, Compound 479 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525790&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390072 463789437 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111532 CC(C)CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCC(CC3)N(C)C)c(F)c2)ncc1F InChI=1S/C29H35F3N6O/c1-18(2)17-38-11-12-39-28-23(31)13-19(14-26(28)38)27-24(32)16-33-29(35-27)34-20-5-6-25(22(30)15-20)37-9-7-21(8-10-37)36(3)4/h5-6,13-16,18,21H,7-12,17H2,1-4H3,(H,33,34,35) MEORLOZUAKLKGF-UHFFFAOYSA-N 525791 US11174252, Compound 480 Cyclin-dependent kinase 6 Homo sapiens 14.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525791&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390098 463789438 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111536 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H24F2N6O/c1-13(2)31-7-8-32-22-16(24)9-15(10-19(22)31)21-17(25)12-27-23(30-21)29-20-4-3-14-11-26-6-5-18(14)28-20/h3-4,9-10,12-13,26H,5-8,11H2,1-2H3,(H,27,28,29,30) PSWOMNFIVDHMDM-UHFFFAOYSA-N 525792 US11174252, Compound 481 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525792&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390209 463789439 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111542 Fc1cc(cc2N(CCOc12)C1CCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H24F2N6O/c25-17-10-15(11-20-23(17)33-9-8-32(20)16-2-1-3-16)22-18(26)13-28-24(31-22)30-21-5-4-14-12-27-7-6-19(14)29-21/h4-5,10-11,13,16,27H,1-3,6-9,12H2,(H,28,29,30,31) DSYAGVYPTCYGKP-UHFFFAOYSA-N 525793 US11174252, Compound 482 Cyclin-dependent kinase 6 Homo sapiens 16.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525793&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389975 463789440 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111548 CC(C)CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H26F2N6O/c1-14(2)13-32-7-8-33-23-17(25)9-16(10-20(23)32)22-18(26)12-28-24(31-22)30-21-4-3-15-11-27-6-5-19(15)29-21/h3-4,9-10,12,14,27H,5-8,11,13H2,1-2H3,(H,28,29,30,31) YPBVPXIBHMXSAS-UHFFFAOYSA-N 525794 US11174252, Compound 483 Cyclin-dependent kinase 6 Homo sapiens 20.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525794&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390194 463789441 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111554 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(C)(O)CC2)ncc1F InChI=1S/C26H30F2N6O2/c1-16(2)34-10-11-36-24-19(27)12-17(13-21(24)34)23-20(28)15-30-25(32-23)31-22-5-4-18(14-29-22)33-8-6-26(3,35)7-9-33/h4-5,12-16,35H,6-11H2,1-3H3,(H,29,30,31,32) FSCDYKUUMJNPMN-UHFFFAOYSA-N 525795 US11174252, Compound 484 Cyclin-dependent kinase 6 Homo sapiens 93.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525795&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390103 463789442 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111558 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(CO)CC2)ncc1F InChI=1S/C26H30F2N6O2/c1-16(2)34-9-10-36-25-20(27)11-18(12-22(25)34)24-21(28)14-30-26(32-24)31-23-4-3-19(13-29-23)33-7-5-17(15-35)6-8-33/h3-4,11-14,16-17,35H,5-10,15H2,1-2H3,(H,29,30,31,32) SGOYVJDFFJKWDN-UHFFFAOYSA-N 525796 US11174252, Compound 485 Cyclin-dependent kinase 6 Homo sapiens 22.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525796&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390188 463789443 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111562 OC1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C4CCC4)c3c2)nc1 InChI=1S/C26H28F2N6O2/c27-20-12-16(13-22-25(20)36-11-10-34(22)17-2-1-3-17)24-21(28)15-30-26(32-24)31-23-5-4-18(14-29-23)33-8-6-19(35)7-9-33/h4-5,12-15,17,19,35H,1-3,6-11H2,(H,29,30,31,32) NBJSISKLAZWALR-UHFFFAOYSA-N 525797 US11174252, Compound 486 Cyclin-dependent kinase 6 Homo sapiens 41.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525797&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390105 463789444 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111566 Fc1cnc(Nc2ccc(cn2)N2CCOCC2)nc1-c1cc(F)c2OCCN(C3CCC3)c2c1 InChI=1S/C25H26F2N6O2/c26-19-12-16(13-21-24(19)35-11-8-33(21)17-2-1-3-17)23-20(27)15-29-25(31-23)30-22-5-4-18(14-28-22)32-6-9-34-10-7-32/h4-5,12-15,17H,1-3,6-11H2,(H,28,29,30,31) YQFQTKOIKKIREQ-UHFFFAOYSA-N 525798 US11174252, Compound 487 Cyclin-dependent kinase 6 Homo sapiens 112 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525798&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390255 463789445 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111570 CC(C)CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(O)CC2)ncc1F InChI=1S/C26H30F2N6O2/c1-16(2)15-34-9-10-36-25-20(27)11-17(12-22(25)34)24-21(28)14-30-26(32-24)31-23-4-3-18(13-29-23)33-7-5-19(35)6-8-33/h3-4,11-14,16,19,35H,5-10,15H2,1-2H3,(H,29,30,31,32) ZASLFNNBUMDNJF-UHFFFAOYSA-N 525799 US11174252, Compound 488 Cyclin-dependent kinase 6 Homo sapiens 200 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525799&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390189 463789446 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111574 CC(C)CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCOCC2)ncc1F InChI=1S/C25H28F2N6O2/c1-16(2)15-33-7-10-35-24-19(26)11-17(12-21(24)33)23-20(27)14-29-25(31-23)30-22-4-3-18(13-28-22)32-5-8-34-9-6-32/h3-4,11-14,16H,5-10,15H2,1-2H3,(H,28,29,30,31) UELAYOOTACICFN-UHFFFAOYSA-N 525800 US11174252, Compound 489 Cyclin-dependent kinase 6 Homo sapiens 159 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525800&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390024 463789447 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111578 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCN(CCO)CC2)ncc1F InChI=1S/C26H31F2N7O2/c1-17(2)35-10-12-37-25-20(27)13-18(14-22(25)35)24-21(28)16-30-26(32-24)31-23-4-3-19(15-29-23)34-7-5-33(6-8-34)9-11-36/h3-4,13-17,36H,5-12H2,1-2H3,(H,29,30,31,32) GPJWAQYXKOYKLZ-UHFFFAOYSA-N 525801 US11174252, Compound 490 Cyclin-dependent kinase 6 Homo sapiens 9.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525801&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390113 463789448 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111582 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(CCO)CC2)ncc1F InChI=1S/C27H32F2N6O2/c1-17(2)35-10-12-37-26-21(28)13-19(14-23(26)35)25-22(29)16-31-27(33-25)32-24-4-3-20(15-30-24)34-8-5-18(6-9-34)7-11-36/h3-4,13-18,36H,5-12H2,1-2H3,(H,30,31,32,33) MENAPVXPHDXOTR-UHFFFAOYSA-N 525802 US11174252, Compound 491 Cyclin-dependent kinase 6 Homo sapiens 31.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525802&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390294 463789449 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111586 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cc(no2)C2CCN(C)CC2)ncc1F InChI=1S/C24H28F2N6O2/c1-14(2)32-8-9-33-23-17(25)10-16(11-20(23)32)22-18(26)13-27-24(29-22)28-21-12-19(30-34-21)15-4-6-31(3)7-5-15/h10-15H,4-9H2,1-3H3,(H,27,28,29) WWUPNOVYRXPGJZ-UHFFFAOYSA-N 525803 US11174252, Compound 495 Cyclin-dependent kinase 6 Homo sapiens 39.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525803&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390173 463789450 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111590 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cn(cn2)C2CCN(C)CC2)ncc1F InChI=1S/C24H29F2N7O/c1-15(2)33-8-9-34-23-18(25)10-16(11-20(23)33)22-19(26)12-27-24(30-22)29-21-13-32(14-28-21)17-4-6-31(3)7-5-17/h10-15,17H,4-9H2,1-3H3,(H,27,29,30) NKUHAYASFJYABY-UHFFFAOYSA-N 525804 US11174252, Compound 496 Cyclin-dependent kinase 6 Homo sapiens >200 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525804&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390212 463789451 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111592 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cnn(c2)C2CCN(C)CC2)ncc1F InChI=1S/C24H29F2N7O/c1-15(2)32-8-9-34-23-19(25)10-16(11-21(23)32)22-20(26)13-27-24(30-22)29-17-12-28-33(14-17)18-4-6-31(3)7-5-18/h10-15,18H,4-9H2,1-3H3,(H,27,29,30) JZIDYKXHTRKVEP-UHFFFAOYSA-N 525805 US11174252, Compound 497 Cyclin-dependent kinase 6 Homo sapiens 14.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525805&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390030 463789452 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111596 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(C)C2)ncc1F InChI=1S/C25H28F2N6O/c1-15(2)33-8-9-34-24-19(26)10-18(11-21(24)33)23-20(27)13-29-25(31-23)30-22-5-4-16(12-28-22)17-6-7-32(3)14-17/h4-5,10-13,15,17H,6-9,14H2,1-3H3,(H,28,29,30,31) UFUZVHSCAUVFOR-UHFFFAOYSA-N 525806 US11174252, Compound 498 Cyclin-dependent kinase 6 Homo sapiens 3.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525806&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390059 463789453 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111600 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cc(n[nH]2)C2CCN(C)CC2)ncc1F InChI=1S/C24H29F2N7O/c1-14(2)33-8-9-34-23-17(25)10-16(11-20(23)33)22-18(26)13-27-24(29-22)28-21-12-19(30-31-21)15-4-6-32(3)7-5-15/h10-15H,4-9H2,1-3H3,(H2,27,28,29,30,31) JJDCFCXCIHINRQ-UHFFFAOYSA-N 525807 US11174252, Compound 499 Cyclin-dependent kinase 6 Homo sapiens 26.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525807&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389981 463789454 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111604 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ncc(cn2)C2CCNCC2)ncc1F InChI=1S/C24H27F2N7O/c1-14(2)33-7-8-34-22-18(25)9-16(10-20(22)33)21-19(26)13-30-24(31-21)32-23-28-11-17(12-29-23)15-3-5-27-6-4-15/h9-15,27H,3-8H2,1-2H3,(H,28,29,30,31,32) CGMQFXGWSKCKSF-UHFFFAOYSA-N 525808 US11174252, Compound 500 Cyclin-dependent kinase 6 Homo sapiens 34.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525808&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390231 463789455 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111606 CCN1CCC(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)nc1 InChI=1S/C27H32F2N6O/c1-4-34-9-7-18(8-10-34)19-5-6-24(30-15-19)32-27-31-16-22(29)25(33-27)20-13-21(28)26-23(14-20)35(17(2)3)11-12-36-26/h5-6,13-18H,4,7-12H2,1-3H3,(H,30,31,32,33) CPJXTPZMRAOYPN-UHFFFAOYSA-N 525809 US11174252, Compound 501 Cyclin-dependent kinase 6 Homo sapiens 5.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525809&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390996 463789456 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111608 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CCNC(=O)c3c2)ncc1F InChI=1S/C24H23F2N5O2/c1-13(2)31-7-8-33-22-18(25)9-15(10-20(22)31)21-19(26)12-28-24(30-21)29-16-4-3-14-5-6-27-23(32)17(14)11-16/h3-4,9-13H,5-8H2,1-2H3,(H,27,32)(H,28,29,30) LGTNVNQWJQDILD-UHFFFAOYSA-N 525810 US11174252, Compound 502 Cyclin-dependent kinase 6 Homo sapiens 28.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525810&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390073 463789457 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111612 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(C)CC3)c(C)n2)ncc1F InChI=1S/C27H32F2N6O/c1-16(2)35-11-12-36-26-21(28)13-19(14-23(26)35)25-22(29)15-30-27(33-25)32-24-6-5-20(17(3)31-24)18-7-9-34(4)10-8-18/h5-6,13-16,18H,7-12H2,1-4H3,(H,30,31,32,33) QYVFFDTUWBVBND-UHFFFAOYSA-N 525811 US11174252, Compound 503 Cyclin-dependent kinase 6 Homo sapiens 18.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525811&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389985 463789458 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111614 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cn(cn2)C2CCNCC2)ncc1F InChI=1S/C23H27F2N7O/c1-14(2)32-7-8-33-22-17(24)9-15(10-19(22)32)21-18(25)11-27-23(30-21)29-20-12-31(13-28-20)16-3-5-26-6-4-16/h9-14,16,26H,3-8H2,1-2H3,(H,27,29,30) GNLQRYDTRRTGFM-UHFFFAOYSA-N 525812 US11174252, Compound 504 Cyclin-dependent kinase 6 Homo sapiens >200 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525812&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390204 463789459 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111616 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cnc(cn2)C2CCNCC2)ncc1F InChI=1S/C24H27F2N7O/c1-14(2)33-7-8-34-23-17(25)9-16(10-20(23)33)22-18(26)11-30-24(32-22)31-21-13-28-19(12-29-21)15-3-5-27-6-4-15/h9-15,27H,3-8H2,1-2H3,(H,29,30,31,32) PFWXLZFOFFJJKK-UHFFFAOYSA-N 525813 US11174252, Compound 505 Cyclin-dependent kinase 6 Homo sapiens 60.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525813&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390256 463789460 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111618 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)CO)ncc1F InChI=1S/C26H29F2N7O3/c1-16(2)35-9-10-38-25-19(27)11-17(12-21(25)35)24-20(28)14-30-26(32-24)31-22-4-3-18(13-29-22)33-5-7-34(8-6-33)23(37)15-36/h3-4,11-14,16,36H,5-10,15H2,1-2H3,(H,29,30,31,32) PTUBNTQWBQUBRX-UHFFFAOYSA-N 525814 US11174252, Compound 506 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525814&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139410427 463789461 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111620 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1F InChI=1S/C21H21F2N5O3S/c1-12(2)28-7-8-31-20-16(22)9-13(10-18(20)28)19-17(23)11-25-21(27-19)26-14-3-5-15(6-4-14)32(24,29)30/h3-6,9-12H,7-8H2,1-2H3,(H2,24,29,30)(H,25,26,27) GNKARCUXNWYAPQ-UHFFFAOYSA-N 525815 US11174252, Compound 507 Cyclin-dependent kinase 6 Homo sapiens 13.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525815&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390084 463789462 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111624 Fc1cc(cc2N(CCOc12)C1CCCC1)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H26F2N6O/c26-18-11-16(12-21-24(18)34-10-9-33(21)17-3-1-2-4-17)23-19(27)14-29-25(32-23)31-22-6-5-15-13-28-8-7-20(15)30-22/h5-6,11-12,14,17,28H,1-4,7-10,13H2,(H,29,30,31,32) HPIIKSFGPMWKJM-UHFFFAOYSA-N 525816 US11174252, Compound 509 Cyclin-dependent kinase 6 Homo sapiens 10.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525816&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390305 463789463 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111628 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(CC2)C(=O)CO)ncc1F InChI=1S/C27H30F2N6O3/c1-16(2)35-9-10-38-26-20(28)11-19(12-22(26)35)25-21(29)14-31-27(33-25)32-23-4-3-18(13-30-23)17-5-7-34(8-6-17)24(37)15-36/h3-4,11-14,16-17,36H,5-10,15H2,1-2H3,(H,30,31,32,33) RNHRCKQJHFBOKM-UHFFFAOYSA-N 525817 US11174252, Compound 510 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525817&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390091 463789464 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111629 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C(=O)N2CC(C)OC(C)C2)ncc1F InChI=1S/C27H30F2N6O3/c1-15(2)35-7-8-37-25-20(28)9-19(10-22(25)35)24-21(29)12-31-27(33-24)32-23-6-5-18(11-30-23)26(36)34-13-16(3)38-17(4)14-34/h5-6,9-12,15-17H,7-8,13-14H2,1-4H3,(H,30,31,32,33) VLMFVPWMCNPJTF-UHFFFAOYSA-N 525818 US11174252, Compound 511 Cyclin-dependent kinase 6 Homo sapiens 16.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525818&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390289 463789465 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111631 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCNCC2=O)ncc1F InChI=1S/C24H25F2N7O2/c1-14(2)32-7-8-35-23-17(25)9-15(10-19(23)32)22-18(26)12-29-24(31-22)30-20-4-3-16(11-28-20)33-6-5-27-13-21(33)34/h3-4,9-12,14,27H,5-8,13H2,1-2H3,(H,28,29,30,31) XCJRUIHXLFTUNW-UHFFFAOYSA-N 525819 US11174252, Compound 512 Cyclin-dependent kinase 6 Homo sapiens 2.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525819&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390177 463789466 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111635 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cc2)S(=O)(=O)NCCN(C)C)ncc1F InChI=1S/C25H30F2N6O3S/c1-16(2)33-11-12-36-24-20(26)13-17(14-22(24)33)23-21(27)15-28-25(31-23)30-18-5-7-19(8-6-18)37(34,35)29-9-10-32(3)4/h5-8,13-16,29H,9-12H2,1-4H3,(H,28,30,31) GKTNOVUFHDVNPA-UHFFFAOYSA-N 525820 US11174252, Compound 513 Cyclin-dependent kinase 6 Homo sapiens 8.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525820&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390037 463789467 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111639 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CC(C)OC(C)C2)ncc1F InChI=1S/C26H30F2N6O2/c1-15(2)34-7-8-35-25-20(27)9-18(10-22(25)34)24-21(28)12-30-26(32-24)31-23-6-5-19(11-29-23)33-13-16(3)36-17(4)14-33/h5-6,9-12,15-17H,7-8,13-14H2,1-4H3,(H,29,30,31,32) IAZQPVCLVPJMHF-UHFFFAOYSA-N 525821 US11174252, Compound 515 Cyclin-dependent kinase 6 Homo sapiens >200 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525821&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390140 463789468 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111641 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(CN3CCN(CC4CC4)CC3)cn2)ncc1F InChI=1S/C29H35F2N7O/c1-19(2)38-11-12-39-28-23(30)13-22(14-25(28)38)27-24(31)16-33-29(35-27)34-26-6-5-21(15-32-26)18-37-9-7-36(8-10-37)17-20-3-4-20/h5-6,13-16,19-20H,3-4,7-12,17-18H2,1-2H3,(H,32,33,34,35) VADHWSWHRRXKCV-UHFFFAOYSA-N 525822 US11174252, Compound 516 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525822&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389968 463789469 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111643 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nn2)C2CCN(C)CC2)ncc1F InChI=1S/C25H29F2N7O/c1-15(2)34-10-11-35-24-18(26)12-17(13-21(24)34)23-19(27)14-28-25(30-23)29-22-5-4-20(31-32-22)16-6-8-33(3)9-7-16/h4-5,12-16H,6-11H2,1-3H3,(H,28,29,30,32) MHBAURANSRCGRJ-UHFFFAOYSA-N 525823 US11174252, Compound 517 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525823&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390132 463789470 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111645 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(CN)CC2)ncc1F InChI=1S/C26H31F2N7O/c1-16(2)35-9-10-36-25-20(27)11-18(12-22(25)35)24-21(28)15-31-26(33-24)32-23-4-3-19(14-30-23)34-7-5-17(13-29)6-8-34/h3-4,11-12,14-17H,5-10,13,29H2,1-2H3,(H,30,31,32,33) CAOFILCIPZJTLM-UHFFFAOYSA-N 525824 US11174252, Compound 518 Cyclin-dependent kinase 6 Homo sapiens 28.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525824&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390077 463789471 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111649 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F InChI=1S/C21H21F2N5O3S/c1-12(2)28-6-7-31-20-16(22)8-13(9-18(20)28)19-17(23)11-25-21(27-19)26-14-4-3-5-15(10-14)32(24,29)30/h3-5,8-12H,6-7H2,1-2H3,(H2,24,29,30)(H,25,26,27) AREQVYHOGWNDNY-UHFFFAOYSA-N 525825 US11174252, Compound 520 Cyclin-dependent kinase 6 Homo sapiens 77.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525825&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139410430 463789472 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111653 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C(N)=O)ncc1F InChI=1S/C21H20F2N6O2/c1-11(2)29-5-6-31-19-14(22)7-13(8-16(19)29)18-15(23)10-26-21(28-18)27-17-4-3-12(9-25-17)20(24)30/h3-4,7-11H,5-6H2,1-2H3,(H2,24,30)(H,25,26,27,28) HWLTZCGRFYEWPQ-UHFFFAOYSA-N 525826 US11174252, Compound 521 Cyclin-dependent kinase 6 Homo sapiens 19.8 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525826&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390263 463789473 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111655 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cc2)S(=O)(=O)N2CCN(C)CC2)ncc1F InChI=1S/C26H30F2N6O3S/c1-17(2)34-12-13-37-25-21(27)14-18(15-23(25)34)24-22(28)16-29-26(31-24)30-19-4-6-20(7-5-19)38(35,36)33-10-8-32(3)9-11-33/h4-7,14-17H,8-13H2,1-3H3,(H,29,30,31) NEXSFQXPWRMTDB-UHFFFAOYSA-N 525827 US11174252, Compound 522 Cyclin-dependent kinase 6 Homo sapiens 105 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525827&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390166 463789474 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111657 COCCNS(=O)(=O)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)cc1 InChI=1S/C24H27F2N5O4S/c1-15(2)31-9-11-35-23-19(25)12-16(13-21(23)31)22-20(26)14-27-24(30-22)29-17-4-6-18(7-5-17)36(32,33)28-8-10-34-3/h4-7,12-15,28H,8-11H2,1-3H3,(H,27,29,30) UVNWLDYNLOHPKC-UHFFFAOYSA-N 525828 US11174252, Compound 523 Cyclin-dependent kinase 6 Homo sapiens 51.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525828&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139389984 463789475 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111661 COCCN1CCN(Cc2cnc(c(F)c2)-c2cc(F)c3OCCN(C(C)C)c3c2)CC1 InChI=1S/C24H32F2N4O2/c1-17(2)30-9-11-32-24-21(26)13-19(14-22(24)30)23-20(25)12-18(15-27-23)16-29-6-4-28(5-7-29)8-10-31-3/h12-15,17H,4-11,16H2,1-3H3 ZCGJMLAZQFNDAN-UHFFFAOYSA-N 525829 US11174252, Compound 524 Cyclin-dependent kinase 6 Homo sapiens 7.50 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525829&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139410381 463789476 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111663 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(N)CC2)ncc1F InChI=1S/C25H29F2N7O/c1-15(2)34-9-10-35-24-19(26)11-16(12-21(24)34)23-20(27)14-30-25(32-23)31-22-4-3-18(13-29-22)33-7-5-17(28)6-8-33/h3-4,11-15,17H,5-10,28H2,1-2H3,(H,29,30,31,32) SLHUOQIIOYHUFR-UHFFFAOYSA-N 525830 US11174252, Compound 788 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525830&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390013 463789477 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111664 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C(N)=O)c(F)c2)ncc1F InChI=1S/C22H20F3N5O2/c1-11(2)30-5-6-32-20-16(24)7-12(8-18(20)30)19-17(25)10-27-22(29-19)28-13-3-4-14(21(26)31)15(23)9-13/h3-4,7-11H,5-6H2,1-2H3,(H2,26,31)(H,27,28,29) BUUPTQBJQWWODA-UHFFFAOYSA-N 525831 US11174252, Compound 790 Cyclin-dependent kinase 6 Homo sapiens 3.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525831&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390139 463789478 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111666 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cc2)S(=O)(=O)NC2CCNCC2)ncc1F InChI=1S/C26H30F2N6O3S/c1-16(2)34-11-12-37-25-21(27)13-17(14-23(25)34)24-22(28)15-30-26(32-24)31-18-3-5-20(6-4-18)38(35,36)33-19-7-9-29-10-8-19/h3-6,13-16,19,29,33H,7-12H2,1-2H3,(H,30,31,32) VHWUUBMRANHHCU-UHFFFAOYSA-N 525832 US11174252, Compound 791 Cyclin-dependent kinase 6 Homo sapiens 41.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525832&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390184 463789479 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111668 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(CN3CCN(C)CC3)c(F)c2)ncc1F InChI=1S/C27H31F3N6O/c1-17(2)36-10-11-37-26-22(29)12-19(13-24(26)36)25-23(30)15-31-27(33-25)32-20-5-4-18(21(28)14-20)16-35-8-6-34(3)7-9-35/h4-5,12-15,17H,6-11,16H2,1-3H3,(H,31,32,33) YUQBNHAASVYJAM-UHFFFAOYSA-N 525833 US11174252, Compound 792 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525833&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390130 463789480 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111670 COC1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)nc1 InChI=1S/C26H30F2N6O2/c1-16(2)34-10-11-36-25-20(27)12-17(13-22(25)34)24-21(28)15-30-26(32-24)31-23-5-4-18(14-29-23)33-8-6-19(35-3)7-9-33/h4-5,12-16,19H,6-11H2,1-3H3,(H,29,30,31,32) UHKSQQNYPYARFR-UHFFFAOYSA-N 525834 US11174252, Compound 843 Cyclin-dependent kinase 6 Homo sapiens 24.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525834&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390023 463789481 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111672 COc1nc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)ccc1C1CCN(C)CC1 InChI=1S/C27H32F2N6O2/c1-16(2)35-11-12-37-25-20(28)13-18(14-22(25)35)24-21(29)15-30-27(33-24)32-23-6-5-19(26(31-23)36-4)17-7-9-34(3)10-8-17/h5-6,13-17H,7-12H2,1-4H3,(H,30,31,32,33) FPYTVDRQKLOFIJ-UHFFFAOYSA-N 525835 US11174252, Compound 844 Cyclin-dependent kinase 6 Homo sapiens 35.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525835&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390144 463789482 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111674 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(C)CC3)c(n2)C#N)ncc1F InChI=1S/C27H29F2N7O/c1-16(2)36-10-11-37-26-20(28)12-18(13-23(26)36)25-21(29)15-31-27(34-25)33-24-5-4-19(22(14-30)32-24)17-6-8-35(3)9-7-17/h4-5,12-13,15-17H,6-11H2,1-3H3,(H,31,32,33,34) AWOBBZHRSADRLH-UHFFFAOYSA-N 525836 US11174252, Compound 845 Cyclin-dependent kinase 6 Homo sapiens 29.0 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525836&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390114 463789483 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111676 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(C)CC3)c(F)n2)ncc1F InChI=1S/C26H29F3N6O/c1-15(2)35-10-11-36-24-19(27)12-17(13-21(24)35)23-20(28)14-30-26(33-23)32-22-5-4-18(25(29)31-22)16-6-8-34(3)9-7-16/h4-5,12-16H,6-11H2,1-3H3,(H,30,31,32,33) PJAZUKUXPBWWHG-UHFFFAOYSA-N 525837 US11174252, Compound 846 Cyclin-dependent kinase 6 Homo sapiens 4.00 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525837&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390239 463789484 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111678 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(C)CC3)c(n2)C2CC2)ncc1F InChI=1S/C29H34F2N6O/c1-17(2)37-12-13-38-28-22(30)14-20(15-24(28)37)27-23(31)16-32-29(35-27)34-25-7-6-21(26(33-25)19-4-5-19)18-8-10-36(3)11-9-18/h6-7,14-19H,4-5,8-13H2,1-3H3,(H,32,33,34,35) UYJPNAFIWZUXNS-UHFFFAOYSA-N 525838 US11174252, Compound 847 Cyclin-dependent kinase 6 Homo sapiens 107 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525838&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390000 463789485 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1111680 CCCc1nc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)ccc1C1CCN(C)CC1 InChI=1S/C29H36F2N6O/c1-5-6-24-21(19-9-11-36(4)12-10-19)7-8-26(33-24)34-29-32-17-23(31)27(35-29)20-15-22(30)28-25(16-20)37(18(2)3)13-14-38-28/h7-8,15-19H,5-6,9-14H2,1-4H3,(H,32,33,34,35) YSGSQQUJYWOWGW-UHFFFAOYSA-N 525839 US11174252, Compound 848 Cyclin-dependent kinase 6 Homo sapiens 110 US Patent 10.7270/Q27D2Z99 aid1806105 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525839&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 139390156 463789486 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174212 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 3.41 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174216 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCN(CC3)C(=O)CO)cn2)ncc1F InChI=1S/C28H30F2N8O2/c1-28(2)6-5-23-34-26-19(29)11-18(12-21(26)38(23)28)25-20(30)14-32-27(35-25)33-22-4-3-17(13-31-22)15-36-7-9-37(10-8-36)24(40)16-39/h3-4,11-14,39H,5-10,15-16H2,1-2H3,(H,31,32,33,35) FMYDWZBWZKJPCK-UHFFFAOYSA-N 556326 1-(4-((6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-ylamino)pyridin-3-yl)methyl)piperazin-1-yl)-2-hydroxyethanone (Compound 22)::US11351170, Example 2 Cyclin-dependent kinase 6 Homo sapiens 8.84 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556326&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513247 471697052 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174220 CN(C)[C@H]1CCN(C1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 InChI=1S/C28H30F2N8O/c1-28(2)9-7-23-34-25-19(29)11-17(12-21(25)38(23)28)24-20(30)14-32-27(35-24)33-22-6-5-16(13-31-22)26(39)37-10-8-18(15-37)36(3)4/h5-6,11-14,18H,7-10,15H2,1-4H3,(H,31,32,33,35)/t18-/m0/s1 QYSWLINIQVNEDI-SFHVURJKSA-N 556327 (S)-(3-(dimethylamino)pyrrolidin-1-yl)(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-ylamino)pyridin-3-yl)methanone ::US11351170, Example 6 Cyclin-dependent kinase 6 Homo sapiens 1.19 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556327&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 142530341 471697053 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174224 CN(C)[C@H]1CCN(C1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 InChI=1S/C27H30F2N8/c1-27(2)9-7-23-33-25-19(28)11-16(12-21(25)37(23)27)24-20(29)14-31-26(34-24)32-22-6-5-17(13-30-22)36-10-8-18(15-36)35(3)4/h5-6,11-14,18H,7-10,15H2,1-4H3,(H,30,31,32,34)/t18-/m0/s1 PJROIFLISSJQQQ-SFHVURJKSA-N 556328 (S)—N-(5-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-amine (Compound 49)::US11351170, Example 7 Cyclin-dependent kinase 6 Homo sapiens 3.96 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556328&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513345 471697054 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174228 CCN1CCC(COc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C29H33F2N7O/c1-4-37-11-8-18(9-12-37)17-39-20-5-6-24(32-15-20)34-28-33-16-22(31)26(36-28)19-13-21(30)27-23(14-19)38-25(35-27)7-10-29(38,2)3/h5-6,13-16,18H,4,7-12,17H2,1-3H3,(H,32,33,34,36) UVVGSZJKQAELIC-UHFFFAOYSA-N 556329 N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-amine (Compound 57)::US11351170, Example 8 Cyclin-dependent kinase 6 Homo sapiens 4.72 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556329&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513620 471697055 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174232 CCN1CCC(COc2ccc(Nc3cc(c(F)cn3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C30H34F2N6O/c1-4-37-11-8-19(9-12-37)18-39-21-5-6-26(33-16-21)35-27-15-22(24(32)17-34-27)20-13-23(31)29-25(14-20)38-28(36-29)7-10-30(38,2)3/h5-6,13-17,19H,4,7-12,18H2,1-3H3,(H,33,34,35) DCRIEDZZYPOGPK-UHFFFAOYSA-N 556330 N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-amine (Compound 60)::US11351170, Example 9 Cyclin-dependent kinase 6 Homo sapiens 2.90 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556330&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513673 471697056 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174236 CN1CCC(CC1)Oc1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 InChI=1S/C27H29F2N7O/c1-27(2)9-6-23-33-25-19(28)12-16(13-21(25)36(23)27)24-20(29)15-31-26(34-24)32-22-5-4-18(14-30-22)37-17-7-10-35(3)11-8-17/h4-5,12-15,17H,6-11H2,1-3H3,(H,30,31,32,34) KHTQGWKOTJZKCD-UHFFFAOYSA-N 556331 5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(1-methylpiperidin-4-yloxy)pyridin-2-yl)pyrimidin-2-amine (Compound 65)::US11351170, Example 10 Cyclin-dependent kinase 6 Homo sapiens 2.46 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556331&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513072 471697057 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174240 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(OCC3CCN(CCCO)CC3)cn2)ncc1F InChI=1S/C30H35F2N7O2/c1-30(2)9-6-26-36-28-22(31)14-20(15-24(28)39(26)30)27-23(32)17-34-29(37-27)35-25-5-4-21(16-33-25)41-18-19-7-11-38(12-8-19)10-3-13-40/h4-5,14-17,19,40H,3,6-13,18H2,1-2H3,(H,33,34,35,37) NXMIQKJGFTVADM-UHFFFAOYSA-N 556334 3-(4-((6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-ylamino)pyridin-3-yloxy)methyl)piperidin-1-yl)propan-1-ol (Compound 72)::US11351170, Example 11 Cyclin-dependent kinase 6 Homo sapiens 1.02 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556334&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513341 471697059 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174244 CN1CCC(COc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C28H31F2N7O/c1-28(2)9-6-24-34-26-20(29)12-18(13-22(26)37(24)28)25-21(30)15-32-27(35-25)33-23-5-4-19(14-31-23)38-16-17-7-10-36(3)11-8-17/h4-5,12-15,17H,6-11,16H2,1-3H3,(H,31,32,33,35) UWEHIBQNZMPNPF-UHFFFAOYSA-N 556335 5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-((1-methylpiperidin-4-yl)methoxy)pyridin-2-yl)pyrimidin-2-amine (Compound 76)::US11351170, Example 12 Cyclin-dependent kinase 6 Homo sapiens 1.89 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556335&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137500765 471697060 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174248 CN1CCC(CC1)OCc1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 InChI=1S/C28H31F2N7O/c1-28(2)9-6-24-34-26-20(29)12-18(13-22(26)37(24)28)25-21(30)15-32-27(35-25)33-23-5-4-17(14-31-23)16-38-19-7-10-36(3)11-8-19/h4-5,12-15,19H,6-11,16H2,1-3H3,(H,31,32,33,35) MYKPWRUVZULGRH-UHFFFAOYSA-N 556336 5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-((1-methylpiperidin-4-yloxy)methyl)pyridin-2-yl)pyrimidin-2-amine (Compound 81)::US11351170, Example 13 Cyclin-dependent kinase 6 Homo sapiens 3.92 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556336&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513121 471697061 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174252 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(OC3CCN(CCO)CC3)cn2)ncc1F InChI=1S/C28H31F2N7O2/c1-28(2)8-5-24-34-26-20(29)13-17(14-22(26)37(24)28)25-21(30)16-32-27(35-25)33-23-4-3-19(15-31-23)39-18-6-9-36(10-7-18)11-12-38/h3-4,13-16,18,38H,5-12H2,1-2H3,(H,31,32,33,35) WQGCPJJNZKLUAU-UHFFFAOYSA-N 556337 2-(4-(6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-ylamino)pyridin-3-yloxy)piperidin-1-yl)ethanol (Compound 87)::US11351170, Example 14 Cyclin-dependent kinase 6 Homo sapiens 2.72 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556337&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137513710 471697062 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174256 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nn5CCCc5c4c3)nc2)CC1 InChI=1S/C26H28F2N8/c1-2-34-8-10-35(11-9-34)16-17-5-6-23(29-14-17)31-26-30-15-21(28)24(32-26)18-12-19-22-4-3-7-36(22)33-25(19)20(27)13-18/h5-6,12-15H,2-4,7-11,16H2,1H3,(H,29,30,31,32) VCVZEWLIGPYLQF-UHFFFAOYSA-N 556338 N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-b]indazol-8-yl)pyrimidin-2-amine (Compound 105)::US11351170, Example 16 Cyclin-dependent kinase 6 Homo sapiens 93.7 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=556338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=556338&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 137501077 471697063 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174260 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 3.41 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174264 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1 InChI=1S/C28H32F2N8/c1-4-36-9-11-37(12-10-36)17-18-5-6-23(31-15-18)33-27-32-16-21(30)25(35-27)19-13-20(29)26-22(14-19)38-24(34-26)7-8-28(38,2)3/h5-6,13-16H,4,7-12,17H2,1-3H3,(H,31,32,33,35) LCDCVRYMEWMBEV-UHFFFAOYSA-N 50455050 CHEMBL4208172::US10696678, Example 18::US11351170, Example 1 Cyclin-dependent kinase 6 Homo sapiens 2.71 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455050&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 122657565 433923192 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174268 CCN1CCC(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 InChI=1S/C28H31F2N7/c1-4-36-11-8-17(9-12-36)18-5-6-23(31-15-18)33-27-32-16-21(30)25(35-27)19-13-20(29)26-22(14-19)37-24(34-26)7-10-28(37,2)3/h5-6,13-17H,4,7-12H2,1-3H3,(H,31,32,33,35) AKUJQCDZMJSNMC-UHFFFAOYSA-N 448950 N-(5-(1-Ethylpiperidine-4-yl)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-amine::US10696678, Example 45::US11351170, Example 4 Cyclin-dependent kinase 6 Homo sapiens 1.93 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448950&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174272 CCN1CCC(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 InChI=1S/C28H31F2N7/c1-4-36-11-8-17(9-12-36)18-5-6-23(31-15-18)33-27-32-16-21(30)25(35-27)19-13-20(29)26-22(14-19)37-24(34-26)7-10-28(37,2)3/h5-6,13-17H,4,7-12H2,1-3H3,(H,31,32,33,35) AKUJQCDZMJSNMC-UHFFFAOYSA-N 448950 N-(5-(1-Ethylpiperidine-4-yl)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-amine::US10696678, Example 45::US11351170, Example 4 Cyclin-dependent kinase 6 Homo sapiens 2.42 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448950&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174276 CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CO)ncc1F InChI=1S/C26H25F2N7O2/c1-26(2)7-5-21-32-24-16(27)9-15(10-19(24)35(21)26)23-17(28)11-29-25(33-23)31-20-4-3-14-12-34(22(37)13-36)8-6-18(14)30-20/h3-4,9-11,36H,5-8,12-13H2,1-2H3,(H,29,30,31,33) VDTYYNPPVROBPA-UHFFFAOYSA-N 448926 1-(2-((5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)-2-hydroxyethan-1-one::US10696678, Example 21::US11351170, Example 5 Cyclin-dependent kinase 6 Homo sapiens 1.87 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448926&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 129102642 440825009 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1174280 CCN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1 InChI=1S/C27H30F2N8/c1-4-35-9-11-36(12-10-35)18-5-6-22(30-15-18)32-26-31-16-20(29)24(34-26)17-13-19(28)25-21(14-17)37-23(33-25)7-8-27(37,2)3/h5-6,13-16H,4,7-12H2,1-3H3,(H,30,31,32,34) RLVCFRZZHAKDOE-UHFFFAOYSA-N 448940 N-(5-(4-Ethylpiperazin-1-yl)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-amine::US10696678, Example 35::US11351170, Example 15 Cyclin-dependent kinase 6 Homo sapiens 0.880 US Patent 10.7270/Q2SJ1PTP aid1806581 US11351170 Song, Y; Chen, X Beijing Xuanyi PharmaSciences Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448940&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430678 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2ccccc2)n1 50578001 CHEMBL4855785 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578001&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 164609699 471054124 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430679 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccccc2)n1 50578008 CHEMBL4856767 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578008&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 164611914 471054131 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430680 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccc(F)cc2)n1 50578010 CHEMBL4860265 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578010&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 164618094 471054133 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430681 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2cccc(F)c2)n1 50578014 CHEMBL4872952 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578014&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 164619500 471054137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430682 Cc1n[nH]c2ccc(cc12)-c1cncc(NC2CCCC(O)C2)n1 50578019 CHEMBL4863726 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578019&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 164622173 471054142 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430683 Cc1n[nH]c2ncc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1Cl 50578021 CHEMBL4857229 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578021&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 164614171 471054144 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430684 Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1Cl 50578022 CHEMBL4876497 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578022&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 162640599 471054145 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51430685 COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m0/s1 XWQVQSXLXAXOPJ-ACRUOGEOSA-N 50553495 CHEMBL4786559 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553495&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 68276369 461692263 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51448025 CN(C)C(=O)c1ccc(Nc2ncc(c(N[C@@H]3CC[C@H](N)CC3)n2)C(F)(F)F)cc1 InChI=1S/C20H25F3N6O/c1-29(2)18(30)12-3-7-15(8-4-12)27-19-25-11-16(20(21,22)23)17(28-19)26-14-9-5-13(24)6-10-14/h3-4,7-8,11,13-14H,5-6,9-10,24H2,1-2H3,(H2,25,26,27,28)/t13-,14+ ZFKQQXLECNVLOF-OKILXGFUSA-N 50584948 CHEMBL5092606 Cyclin-dependent kinase 6 Homo sapiens 1417 ChEMBL 10.1021/acs.jmedchem.1c01792 10.7270/Q2XG9W1F 35138851 Tong, L; Wang, P; Li, X; Dong, X; Hu, X; Wang, C; Liu, T; Li, J; Zhou, Y Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584948&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 163322041 476021035 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51448026 Cn1ccc2cc(Nc3ncc(c(N[C@@H]4CC[C@H](N)CC4)n3)C(F)(F)F)ccc2c1=O InChI=1S/C21H23F3N6O/c1-30-9-8-12-10-15(6-7-16(12)19(30)31)28-20-26-11-17(21(22,23)24)18(29-20)27-14-4-2-13(25)3-5-14/h6-11,13-14H,2-5,25H2,1H3,(H2,26,27,28,29)/t13-,14+ LSEAQLOYCHTEOK-OKILXGFUSA-N 50584949 CHEMBL5089164 Cyclin-dependent kinase 6 Homo sapiens 2668 ChEMBL 10.1021/acs.jmedchem.1c01792 10.7270/Q2XG9W1F 35138851 Tong, L; Wang, P; Li, X; Dong, X; Hu, X; Wang, C; Liu, T; Li, J; Zhou, Y Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584949&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 155668690 476021036 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443528 CC(C)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nccnc3c2)nc1 InChI=1S/C25H25FN8O/c1-16(2)33-9-11-34(12-10-33)24(35)18-4-6-22(29-14-18)31-25-30-15-19(26)23(32-25)17-3-5-20-21(13-17)28-8-7-27-20/h3-8,13-16H,9-12H2,1-2H3,(H,29,30,31,32) YUBRBDXXLWXNKR-UHFFFAOYSA-N 50583149 CHEMBL5078670 Cyclin-dependent kinase 6 Homo sapiens 308 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583149&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166629425 476028154 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443529 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nccnc3c2)nc1 InChI=1S/C27H27FN8O3/c1-27(2,3)39-26(38)36-12-10-35(11-13-36)24(37)18-5-7-22(31-15-18)33-25-32-16-19(28)23(34-25)17-4-6-20-21(14-17)30-9-8-29-20/h4-9,14-16H,10-13H2,1-3H3,(H,31,32,33,34) WNYCRTODSXZWIK-UHFFFAOYSA-N 50583150 CHEMBL5075657 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583150&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166626090 476028155 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443530 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nccnc3c2)nc1 InChI=1S/C23H21FN8O/c1-31-8-10-32(11-9-31)22(33)16-3-5-20(27-13-16)29-23-28-14-17(24)21(30-23)15-2-4-18-19(12-15)26-7-6-25-18/h2-7,12-14H,8-11H2,1H3,(H,27,28,29,30) GBXKJJKTNOLFGK-UHFFFAOYSA-N 50583151 CHEMBL5082257 Cyclin-dependent kinase 6 Homo sapiens 282 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583151&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166628391 476028156 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443531 Fc1cnc(Nc2ccc(cn2)C(=O)N2CCNCC2)nc1-c1ccc2nccnc2c1 InChI=1S/C22H19FN8O/c23-16-13-28-22(30-20(16)14-1-3-17-18(11-14)26-6-5-25-17)29-19-4-2-15(12-27-19)21(32)31-9-7-24-8-10-31/h1-6,11-13,24H,7-10H2,(H,27,28,29,30) VOWPPENXFJCQKK-UHFFFAOYSA-N 50583152 CHEMBL5088816 Cyclin-dependent kinase 6 Homo sapiens 199 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583152&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166632315 476028157 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443532 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nccnc4c3)nc2)CC1 InChI=1S/C25H27FN8/c1-17(2)34-11-9-33(10-12-34)16-18-3-6-23(29-14-18)31-25-30-15-20(26)24(32-25)19-4-5-21-22(13-19)28-8-7-27-21/h3-8,13-15,17H,9-12,16H2,1-2H3,(H,29,30,31,32) MQCKGICMPDECTO-UHFFFAOYSA-N 50583153 CHEMBL5085873 Cyclin-dependent kinase 6 Homo sapiens 315 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583153&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166634214 476028158 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443533 CS(=O)(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nccnc4c3)nc2)CC1 InChI=1S/C23H23FN8O2S/c1-35(33,34)32-10-8-31(9-11-32)15-16-2-5-21(27-13-16)29-23-28-14-18(24)22(30-23)17-3-4-19-20(12-17)26-7-6-25-19/h2-7,12-14H,8-11,15H2,1H3,(H,27,28,29,30) YXNXMBFQJHZWSO-UHFFFAOYSA-N 50583154 CHEMBL5093557 Cyclin-dependent kinase 6 Homo sapiens 351 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583154&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166633799 476028159 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443534 CCOC(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nccnc4c3)nc2)CC1 InChI=1S/C25H25FN8O2/c1-2-36-25(35)34-11-9-33(10-12-34)16-17-3-6-22(29-14-17)31-24-30-15-19(26)23(32-24)18-4-5-20-21(13-18)28-8-7-27-20/h3-8,13-15H,2,9-12,16H2,1H3,(H,29,30,31,32) SNTVNRBNNVTVBW-UHFFFAOYSA-N 50583155 CHEMBL5074598 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583155&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166636529 476028160 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443535 CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nccnc3c2)nc1 InChI=1S/C26H27FN8O2/c1-26(2,3)37-25(36)35-12-10-34(11-13-35)18-5-7-22(30-15-18)32-24-31-16-19(27)23(33-24)17-4-6-20-21(14-17)29-9-8-28-20/h4-9,14-16H,10-13H2,1-3H3,(H,30,31,32,33) RGHAEIOBJSSDAK-UHFFFAOYSA-N 50583156 CHEMBL5088191 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583156&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166632639 476028161 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443536 Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1ccc2nccnc2c1 InChI=1S/C21H19FN8/c22-16-13-27-21(28-19-4-2-15(12-26-19)30-9-7-23-8-10-30)29-20(16)14-1-3-17-18(11-14)25-6-5-24-17/h1-6,11-13,23H,7-10H2,(H,26,27,28,29) IRQBQPNOWKSJBR-UHFFFAOYSA-N 50583157 CHEMBL5082230 Cyclin-dependent kinase 6 Homo sapiens 118 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583157&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166629558 476028162 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443537 CC(C)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(C)c(C)nc3c2)nc1 InChI=1S/C27H29FN8O/c1-16(2)35-9-11-36(12-10-35)26(37)20-6-8-24(29-14-20)33-27-30-15-21(28)25(34-27)19-5-7-22-23(13-19)32-18(4)17(3)31-22/h5-8,13-16H,9-12H2,1-4H3,(H,29,30,33,34) JUZANJIMZRAQDG-UHFFFAOYSA-N 50583158 CHEMBL5080781 Cyclin-dependent kinase 6 Homo sapiens 544 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583158&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166628791 476028163 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443538 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(C)c(C)nc3c2)nc1 InChI=1S/C25H25FN8O/c1-15-16(2)30-21-12-17(4-6-20(21)29-15)23-19(26)14-28-25(32-23)31-22-7-5-18(13-27-22)24(35)34-10-8-33(3)9-11-34/h4-7,12-14H,8-11H2,1-3H3,(H,27,28,31,32) JKMZYDDGZWQHSL-UHFFFAOYSA-N 50583159 CHEMBL5093550 Cyclin-dependent kinase 6 Homo sapiens 1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583159&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166633796 476028164 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443539 Cc1nc2ccc(cc2nc1C)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C29H31FN8O3/c1-17-18(2)34-23-14-19(6-8-22(23)33-17)25-21(30)16-32-27(36-25)35-24-9-7-20(15-31-24)26(39)37-10-12-38(13-11-37)28(40)41-29(3,4)5/h6-9,14-16H,10-13H2,1-5H3,(H,31,32,35,36) PKEQAMPOUXEJLS-UHFFFAOYSA-N 50583160 CHEMBL5092066 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583160&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166634705 476028165 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443540 Cc1nc2ccc(cc2nc1C)-c1nc(Nc2ccc(cn2)C(=O)N2CCNCC2)ncc1F InChI=1S/C24H23FN8O/c1-14-15(2)30-20-11-16(3-5-19(20)29-14)22-18(25)13-28-24(32-22)31-21-6-4-17(12-27-21)23(34)33-9-7-26-8-10-33/h3-6,11-13,26H,7-10H2,1-2H3,(H,27,28,31,32) PVZHWRGPKVCTLJ-UHFFFAOYSA-N 50583161 CHEMBL5085969 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583161&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166631305 476028166 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443541 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(C)c(C)nc4c3)nc2)CC1 InChI=1S/C27H31FN8/c1-17(2)36-11-9-35(10-12-36)16-20-5-8-25(29-14-20)33-27-30-15-22(28)26(34-27)21-6-7-23-24(13-21)32-19(4)18(3)31-23/h5-8,13-15,17H,9-12,16H2,1-4H3,(H,29,30,33,34) CXAJVIUXPOHUTG-UHFFFAOYSA-N 50583162 CHEMBL5073277 Cyclin-dependent kinase 6 Homo sapiens 781 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583162&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166630561 476028167 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443542 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(C)c(C)nc4c3)nc2)CC1 InChI=1S/C26H29FN8/c1-4-34-9-11-35(12-10-34)16-19-5-8-24(28-14-19)32-26-29-15-21(27)25(33-26)20-6-7-22-23(13-20)31-18(3)17(2)30-22/h5-8,13-15H,4,9-12,16H2,1-3H3,(H,28,29,32,33) BXENBMCFYWCMMY-UHFFFAOYSA-N 50583163 CHEMBL5088870 Cyclin-dependent kinase 6 Homo sapiens 611 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583163&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166632956 476028168 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443543 Cc1nc2ccc(cc2nc1C)-c1nc(Nc2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cn2)ncc1F InChI=1S/C29H33FN8O2/c1-18-19(2)34-24-14-21(7-8-23(24)33-18)26-22(30)16-32-27(36-26)35-25-9-6-20(15-31-25)17-37-10-12-38(13-11-37)28(39)40-29(3,4)5/h6-9,14-16H,10-13,17H2,1-5H3,(H,31,32,35,36) WMUNSTGTIPMDHX-UHFFFAOYSA-N 50583164 CHEMBL5084346 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583164&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166631894 476028169 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443544 Cc1nc2ccc(cc2nc1C)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F InChI=1S/C24H25FN8/c1-15-16(2)30-21-11-18(4-5-20(21)29-15)23-19(25)13-28-24(32-23)31-22-6-3-17(12-27-22)14-33-9-7-26-8-10-33/h3-6,11-13,26H,7-10,14H2,1-2H3,(H,27,28,31,32) VTSKTWVMCIBKDT-UHFFFAOYSA-N 50583165 CHEMBL5074718 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583165&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166636593 476028170 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443545 Cc1nc2ccc(cc2nc1C)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C28H31FN8O2/c1-17-18(2)33-23-14-19(6-8-22(23)32-17)25-21(29)16-31-26(35-25)34-24-9-7-20(15-30-24)36-10-12-37(13-11-36)27(38)39-28(3,4)5/h6-9,14-16H,10-13H2,1-5H3,(H,30,31,34,35) QLJQKBOHICMJTN-UHFFFAOYSA-N 50583166 CHEMBL5094024 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583166&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166636203 476028171 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443546 Cc1nc2ccc(cc2nc1C)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C23H23FN8/c1-14-15(2)29-20-11-16(3-5-19(20)28-14)22-18(24)13-27-23(31-22)30-21-6-4-17(12-26-21)32-9-7-25-8-10-32/h3-6,11-13,25H,7-10H2,1-2H3,(H,26,27,30,31) MQSVIANYXKTUMS-UHFFFAOYSA-N 50583167 CHEMBL5090931 Cyclin-dependent kinase 6 Homo sapiens 204 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583167&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166632386 476028172 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443547 CC(C)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncc(nc3c2)N(C)C)nc1 InChI=1S/C27H30FN9O/c1-17(2)36-9-11-37(12-10-36)26(38)19-6-8-23(30-14-19)33-27-31-15-20(28)25(34-27)18-5-7-21-22(13-18)32-24(16-29-21)35(3)4/h5-8,13-17H,9-12H2,1-4H3,(H,30,31,33,34) DEIFYFMWJVRUHV-UHFFFAOYSA-N 50583168 CHEMBL5077271 Cyclin-dependent kinase 6 Homo sapiens 118 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583168&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166626758 476028173 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443548 CN(C)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C29H32FN9O3/c1-29(2,3)42-28(41)39-12-10-38(11-13-39)26(40)19-7-9-23(32-15-19)35-27-33-16-20(30)25(36-27)18-6-8-21-22(14-18)34-24(17-31-21)37(4)5/h6-9,14-17H,10-13H2,1-5H3,(H,32,33,35,36) JWEFVDWPQGQJDV-UHFFFAOYSA-N 50583169 CHEMBL5086434 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583169&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166631667 476028174 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443549 CN(C)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)C(=O)N2CCNCC2)ncc1F InChI=1S/C24H24FN9O/c1-33(2)21-14-27-18-5-3-15(11-19(18)30-21)22-17(25)13-29-24(32-22)31-20-6-4-16(12-28-20)23(35)34-9-7-26-8-10-34/h3-6,11-14,26H,7-10H2,1-2H3,(H,28,29,31,32) WUPRAHSNJBLKQZ-UHFFFAOYSA-N 50583170 CHEMBL5081489 Cyclin-dependent kinase 6 Homo sapiens 102 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583170&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166628813 476028175 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443550 CN(C)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C28H32FN9O2/c1-28(2,3)40-27(39)38-12-10-37(11-13-38)19-7-9-23(31-15-19)34-26-32-16-20(29)25(35-26)18-6-8-21-22(14-18)33-24(17-30-21)36(4)5/h6-9,14-17H,10-13H2,1-5H3,(H,31,32,34,35) SBXXIBUTYOCORP-UHFFFAOYSA-N 50583171 CHEMBL5092768 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583171&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166633043 476028176 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443551 CN(C)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C23H24FN9/c1-32(2)21-14-26-18-5-3-15(11-19(18)29-21)22-17(24)13-28-23(31-22)30-20-6-4-16(12-27-20)33-9-7-25-8-10-33/h3-6,11-14,25H,7-10H2,1-2H3,(H,27,28,30,31) CVBIOKGKBZUACK-UHFFFAOYSA-N 50583172 CHEMBL5089915 Cyclin-dependent kinase 6 Homo sapiens 97 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583172&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166635385 476028177 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443552 CC(C)N1CCN(CC1)C(=O)c1ccc(Nc2nccc(n2)-c2ccc3ncc(nc3c2)N(C)C)nc1 InChI=1S/C27H31N9O/c1-18(2)35-11-13-36(14-12-35)26(37)20-6-8-24(30-16-20)33-27-28-10-9-21(32-27)19-5-7-22-23(15-19)31-25(17-29-22)34(3)4/h5-10,15-18H,11-14H2,1-4H3,(H,28,30,32,33) LQEQTMUEDFLDQN-UHFFFAOYSA-N 50583173 CHEMBL5091949 Cyclin-dependent kinase 6 Homo sapiens 1705 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583173&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166636139 476028178 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443553 CN(C)c1cnc2ccc(cc2n1)-c1ccnc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)n1 InChI=1S/C29H33N9O3/c1-29(2,3)41-28(40)38-14-12-37(13-15-38)26(39)20-7-9-24(32-17-20)35-27-30-11-10-21(34-27)19-6-8-22-23(16-19)33-25(18-31-22)36(4)5/h6-11,16-18H,12-15H2,1-5H3,(H,30,32,34,35) XSNKTWOJFUJFNJ-UHFFFAOYSA-N 50583174 CHEMBL5078974 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583174&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166627834 476028179 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443554 CN(C)c1cnc2ccc(cc2n1)-c1ccnc(Nc2ccc(cn2)C(=O)N2CCNCC2)n1 InChI=1S/C24H25N9O/c1-32(2)22-15-27-19-5-3-16(13-20(19)29-22)18-7-8-26-24(30-18)31-21-6-4-17(14-28-21)23(34)33-11-9-25-10-12-33/h3-8,13-15,25H,9-12H2,1-2H3,(H,26,28,30,31) BFNRBHKUHZSYGJ-UHFFFAOYSA-N 50583175 CHEMBL5071850 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583175&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166630722 476028180 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443555 CN(C)c1cnc2ccc(cc2n1)-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)C(=O)OC(C)(C)C)n1 InChI=1S/C28H33N9O2/c1-28(2,3)39-27(38)37-14-12-36(13-15-37)20-7-9-24(31-17-20)34-26-29-11-10-21(33-26)19-6-8-22-23(16-19)32-25(18-30-22)35(4)5/h6-11,16-18H,12-15H2,1-5H3,(H,29,31,33,34) LENACEFVVLJJPE-UHFFFAOYSA-N 50583176 CHEMBL5094031 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583176&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166636209 476028181 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443556 CN(C)c1cnc2ccc(cc2n1)-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C23H25N9/c1-31(2)22-15-26-19-5-3-16(13-20(19)28-22)18-7-8-25-23(29-18)30-21-6-4-17(14-27-21)32-11-9-24-10-12-32/h3-8,13-15,24H,9-12H2,1-2H3,(H,25,27,29,30) ULIBSXYAHOPRON-UHFFFAOYSA-N 50583177 CHEMBL5081097 Cyclin-dependent kinase 6 Homo sapiens 524 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583177&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166628804 476028182 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443557 COc1cnc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(C)C)nc1-c1ccc2ncc(nc2c1)N(C)C InChI=1S/C28H33N9O2/c1-18(2)36-10-12-37(13-11-36)27(38)20-7-9-24(30-15-20)33-28-31-16-23(39-5)26(34-28)19-6-8-21-22(14-19)32-25(17-29-21)35(3)4/h6-9,14-18H,10-13H2,1-5H3,(H,30,31,33,34) XDVWTECIWTZFHX-UHFFFAOYSA-N 50583178 CHEMBL5079080 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583178&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166629698 476028183 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443558 COc1cnc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)nc1-c1ccc2ncc(nc2c1)N(C)C InChI=1S/C30H35N9O4/c1-30(2,3)43-29(41)39-13-11-38(12-14-39)27(40)20-8-10-24(32-16-20)35-28-33-17-23(42-6)26(36-28)19-7-9-21-22(15-19)34-25(18-31-21)37(4)5/h7-10,15-18H,11-14H2,1-6H3,(H,32,33,35,36) SCEMCQRCVZKEME-UHFFFAOYSA-N 50583179 CHEMBL5085785 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583179&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166631952 476028184 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443559 COc1cnc(Nc2ccc(cn2)C(=O)N2CCNCC2)nc1-c1ccc2ncc(nc2c1)N(C)C InChI=1S/C25H27N9O2/c1-33(2)22-15-27-18-6-4-16(12-19(18)30-22)23-20(36-3)14-29-25(32-23)31-21-7-5-17(13-28-21)24(35)34-10-8-26-9-11-34/h4-7,12-15,26H,8-11H2,1-3H3,(H,28,29,31,32) NNWSGVSQWRVOIZ-UHFFFAOYSA-N 50583180 CHEMBL5091299 Cyclin-dependent kinase 6 Homo sapiens 1385 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583180&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166632078 476028185 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443560 COc1cnc(Nc2ccc(cn2)N2CCN(CC2)C(=O)OC(C)(C)C)nc1-c1ccc2ncc(nc2c1)N(C)C InChI=1S/C29H35N9O3/c1-29(2,3)41-28(39)38-13-11-37(12-14-38)20-8-10-24(31-16-20)34-27-32-17-23(40-6)26(35-27)19-7-9-21-22(15-19)33-25(18-30-21)36(4)5/h7-10,15-18H,11-14H2,1-6H3,(H,31,32,34,35) JFFJETSLPZDYRU-UHFFFAOYSA-N 50583181 CHEMBL5084718 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583181&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166635568 476028186 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443561 COc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1ccc2ncc(nc2c1)N(C)C InChI=1S/C24H27N9O/c1-32(2)22-15-26-18-6-4-16(12-19(18)29-22)23-20(34-3)14-28-24(31-23)30-21-7-5-17(13-27-21)33-10-8-25-9-11-33/h4-7,12-15,25H,8-11H2,1-3H3,(H,27,28,30,31) PYGDDWKLNMOEIZ-UHFFFAOYSA-N 50583182 CHEMBL5094319 Cyclin-dependent kinase 6 Homo sapiens 646 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583182&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166631575 476028187 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443562 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(C)C)ncc1F InChI=1S/C29H34FN9O/c1-5-37(6-2)26-18-31-23-9-7-20(15-24(23)34-26)27-22(30)17-33-29(36-27)35-25-10-8-21(16-32-25)28(40)39-13-11-38(12-14-39)19(3)4/h7-10,15-19H,5-6,11-14H2,1-4H3,(H,32,33,35,36) XDZYAZWBMVQUTC-UHFFFAOYSA-N 50583183 CHEMBL5076627 Cyclin-dependent kinase 6 Homo sapiens 174 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166626343 476028188 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443563 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC)CC2)ncc1F InChI=1S/C28H32FN9O/c1-4-36-11-13-38(14-12-36)27(39)20-8-10-24(31-16-20)34-28-32-17-21(29)26(35-28)19-7-9-22-23(15-19)33-25(18-30-22)37(5-2)6-3/h7-10,15-18H,4-6,11-14H2,1-3H3,(H,31,32,34,35) VGUSDTHMMMIGPF-UHFFFAOYSA-N 50583184 CHEMBL5081007 Cyclin-dependent kinase 6 Homo sapiens 272 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583184&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166627597 476028189 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443564 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C31H36FN9O3/c1-6-39(7-2)26-19-33-23-10-8-20(16-24(23)36-26)27-22(32)18-35-29(38-27)37-25-11-9-21(17-34-25)28(42)40-12-14-41(15-13-40)30(43)44-31(3,4)5/h8-11,16-19H,6-7,12-15H2,1-5H3,(H,34,35,37,38) NNPSABUYEQERGD-UHFFFAOYSA-N 50583185 CHEMBL5094638 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583185&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166633122 476028190 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443565 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)C(=O)N2CCNCC2)ncc1F InChI=1S/C26H28FN9O/c1-3-35(4-2)23-16-29-20-7-5-17(13-21(20)32-23)24-19(27)15-31-26(34-24)33-22-8-6-18(14-30-22)25(37)36-11-9-28-10-12-36/h5-8,13-16,28H,3-4,9-12H2,1-2H3,(H,30,31,33,34) PTMADKDGOQDQEW-UHFFFAOYSA-N 50583186 CHEMBL5083405 Cyclin-dependent kinase 6 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583186&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166629866 476028191 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443566 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(CN3CCN(CC3)C(C)C)cn2)ncc1F InChI=1S/C29H36FN9/c1-5-38(6-2)27-18-31-24-9-8-22(15-25(24)34-27)28-23(30)17-33-29(36-28)35-26-10-7-21(16-32-26)19-37-11-13-39(14-12-37)20(3)4/h7-10,15-18,20H,5-6,11-14,19H2,1-4H3,(H,32,33,35,36) LJLMRYGLLGDWLC-UHFFFAOYSA-N 50583187 CHEMBL5093528 Cyclin-dependent kinase 6 Homo sapiens 258 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583187&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166633400 476028192 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443567 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C30H36FN9O2/c1-6-38(7-2)26-19-32-23-10-8-20(16-24(23)35-26)27-22(31)18-34-28(37-27)36-25-11-9-21(17-33-25)39-12-14-40(15-13-39)29(41)42-30(3,4)5/h8-11,16-19H,6-7,12-15H2,1-5H3,(H,33,34,36,37) SWGBGQADKNKSOQ-UHFFFAOYSA-N 50583188 CHEMBL5087684 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583188&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166633569 476028193 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443568 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C25H28FN9/c1-3-34(4-2)23-16-28-20-7-5-17(13-21(20)31-23)24-19(26)15-30-25(33-24)32-22-8-6-18(14-29-22)35-11-9-27-10-12-35/h5-8,13-16,27H,3-4,9-12H2,1-2H3,(H,29,30,32,33) SKOICOFQIQHEPE-UHFFFAOYSA-N 50583189 CHEMBL5079648 Cyclin-dependent kinase 6 Homo sapiens 39 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583189&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 163196279 476028194 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443569 CCN(CC)c1cnc2ccc(cc2n1)-c1nc(Nc2ccc(cn2)N2CCN(C)CC2)ncc1F InChI=1S/C26H30FN9/c1-4-35(5-2)24-17-28-21-8-6-18(14-22(21)31-24)25-20(27)16-30-26(33-25)32-23-9-7-19(15-29-23)36-12-10-34(3)11-13-36/h6-9,14-17H,4-5,10-13H2,1-3H3,(H,29,30,32,33) BNQBOBDSVGXIIF-UHFFFAOYSA-N 50583190 CHEMBL5089214 Cyclin-dependent kinase 6 Homo sapiens 306 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583190&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166634000 476028195 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443570 CC(C)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncc(nc3c2)N2CCOCC2)nc1 InChI=1S/C29H32FN9O2/c1-19(2)37-7-9-39(10-8-37)28(40)21-4-6-25(32-16-21)35-29-33-17-22(30)27(36-29)20-3-5-23-24(15-20)34-26(18-31-23)38-11-13-41-14-12-38/h3-6,15-19H,7-14H2,1-2H3,(H,32,33,35,36) UNZMEFDCYCSOSI-UHFFFAOYSA-N 50583191 CHEMBL5079586 Cyclin-dependent kinase 6 Homo sapiens 611 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583191&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166629456 476028196 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443571 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncc(nc3c2)N2CCOCC2)nc1 InChI=1S/C31H34FN9O4/c1-31(2,3)45-30(43)41-10-8-40(9-11-41)28(42)21-5-7-25(34-17-21)37-29-35-18-22(32)27(38-29)20-4-6-23-24(16-20)36-26(19-33-23)39-12-14-44-15-13-39/h4-7,16-19H,8-15H2,1-3H3,(H,34,35,37,38) YTCKPXNWYCASJQ-UHFFFAOYSA-N 50583192 CHEMBL5090631 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583192&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166633703 476028197 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443572 Fc1cnc(Nc2ccc(cn2)C(=O)N2CCNCC2)nc1-c1ccc2ncc(nc2c1)N1CCOCC1 InChI=1S/C26H26FN9O2/c27-19-15-31-26(33-22-4-2-18(14-30-22)25(37)36-7-5-28-6-8-36)34-24(19)17-1-3-20-21(13-17)32-23(16-29-20)35-9-11-38-12-10-35/h1-4,13-16,28H,5-12H2,(H,30,31,33,34) HHUITPYJTITMMF-UHFFFAOYSA-N 50583193 CHEMBL5085896 Cyclin-dependent kinase 6 Homo sapiens 175 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583193&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166634881 476028198 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443573 CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncc(nc3c2)N2CCOCC2)nc1 InChI=1S/C30H34FN9O3/c1-30(2,3)43-29(41)40-10-8-38(9-11-40)21-5-7-25(33-17-21)36-28-34-18-22(31)27(37-28)20-4-6-23-24(16-20)35-26(19-32-23)39-12-14-42-15-13-39/h4-7,16-19H,8-15H2,1-3H3,(H,33,34,36,37) QQKXRKKGSSNZKU-UHFFFAOYSA-N 50583194 CHEMBL5089681 Cyclin-dependent kinase 6 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583194&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166634660 476028199 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51443574 Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1ccc2ncc(nc2c1)N1CCOCC1 InChI=1S/C25H26FN9O/c26-19-15-30-25(32-22-4-2-18(14-29-22)34-7-5-27-6-8-34)33-24(19)17-1-3-20-21(13-17)31-23(16-28-20)35-9-11-36-12-10-35/h1-4,13-16,27H,5-12H2,(H,29,30,32,33) ZINMQNQKXGNWQN-UHFFFAOYSA-N 50583195 CHEMBL5077663 Cyclin-dependent kinase 6 Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.1c02019 10.7270/Q2D222HB 34958208 Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583195&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166626586 476028200 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51466671 C[C@H]1C[C@@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O InChI=1S/C22H19N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13H,8-11H2,1H3/b19-14-/t12-,13+/m0/s1 VHRVZYTVMBOFAO-NDQRQRNDSA-N 50591706 CHEMBL5184492 Cyclin-dependent kinase 6 Homo sapiens 12000 ChEMBL 10.7270/Q2XW4PS2 34998058 Jiang, X; Wu, K; Bai, R; Zhang, P; Zhang, Y Central South University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591706&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 168282162 482602558 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51488918 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Cyclin-dependent kinase 6 Homo sapiens 4.0 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51488982 CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3)-c3csc4c3oc(cc4=O)N3CCOCC3)nc2n1C1CCCC1 InChI=1S/C31H32N6O4S/c1-35(2)30(39)24-15-20-17-32-31(34-29(20)37(24)22-5-3-4-6-22)33-21-9-7-19(8-10-21)23-18-42-28-25(38)16-26(41-27(23)28)36-11-13-40-14-12-36/h7-10,15-18,22H,3-6,11-14H2,1-2H3,(H,32,33,34) XJKTXWSMMWPNTP-UHFFFAOYSA-N 50600028 CHEMBL5190816 Cyclin-dependent kinase 6 Homo sapiens 3.3 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50600028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50600028&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search YR0 153289441 482610880 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51478278 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 16 ChEMBL 10.7270/Q24Q801K 33539089 Raghuvanshi, R; Bharate, SB CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51478424 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 16 ChEMBL 10.7270/Q20Z779V 33970631 García-Cárceles, J; Caballero, E; Gil, C; Martínez, A Centro de Investigaciones Biol�gicas Margarita Salas (CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51478425 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 6 Homo sapiens 60 ChEMBL 10.7270/Q20Z779V 33970631 García-Cárceles, J; Caballero, E; Gil, C; Martínez, A Centro de Investigaciones Biol�gicas Margarita Salas (CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51461709 Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)cn1 InChI=1S/C19H15F3N4O2/c20-19(21,22)12-2-1-3-14(10-12)26-18(27)25-13-4-6-15(7-5-13)28-16-8-9-17(23)24-11-16/h1-11H,(H2,23,24)(H2,25,26,27) MBIXOXMOHXFUFZ-UHFFFAOYSA-N 50589846 CHEMBL5190752 Cyclin-dependent kinase 6 Homo sapiens 251 ChEMBL 10.7270/Q28W3J8D 36126227 Yan, YY; Zhang, XX; Xiao, Y; Shen, XB; Jian, YJ; Wang, YM; She, ZH; Liu, MM; Liu, XH Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589846&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 165412810 482600698 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51492144 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 16 ChEMBL 10.7270/Q2PN99PG 33540357 Wang, S; Yuan, XH; Wang, SQ; Zhao, W; Chen, XB; Yu, B Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51492145 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-dependent kinase 6 Homo sapiens 39 ChEMBL 10.7270/Q2PN99PG 33540357 Wang, S; Yuan, XH; Wang, SQ; Zhao, W; Chen, XB; Yu, B Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51492252 C[C@H]1CC[C@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(=O)CO)nc12 InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)/t16-,18+ BBUVDDPUURMFOX-MAEOIBBWSA-N 50601439 CHEMBL5207533 Cyclin-dependent kinase 6 Homo sapiens 8.0 ChEMBL 10.7270/Q25Q515Z 33719439 Wang, Z; Cai, J; Cheng, J; Yang, W; Zhu, Y; Li, H; Lu, T; Chen, Y; Lu, S China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50601439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50601439&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 60202647 482612291 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325266 CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncsc3c2)nc1 InChI=1S/C23H22FN7OS/c1-2-30-7-9-31(10-8-30)22(32)16-4-6-20(25-12-16)28-23-26-13-17(24)21(29-23)15-3-5-18-19(11-15)33-14-27-18/h3-6,11-14H,2,7-10H2,1H3,(H,25,26,28,29) SDQPABOSBRYYPV-UHFFFAOYSA-N 620995 (6-((4-(benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(4-ethylpiperazine-1-yl)ketone::US20230303553, Example 1 Cyclin-dependent kinase 6 Homo sapiens 144 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=620995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=620995&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073876 485228157 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325267 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(NC5CCCC5)sc4c3)nc2)CC1 InChI=1S/C28H33FN8S/c1-2-36-11-13-37(14-12-36)18-19-7-10-25(30-16-19)34-27-31-17-22(29)26(35-27)20-8-9-23-24(15-20)38-28(33-23)32-21-5-3-4-6-21/h7-10,15-17,21H,2-6,11-14,18H2,1H3,(H,32,33)(H,30,31,34,35) BIQADQASLLQRRS-UHFFFAOYSA-N 620998 N-cyclopentyl-6-(2-((5-((4-ethylpiperazine-1-yl)methyl)pyridine-2-yl)amino)-5-fluoropyrimidine-4-yl)benzothiazole-2-amine::US20230303553, Example 19 Cyclin-dependent kinase 6 Homo sapiens 96.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=620998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=620998&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073886 485228160 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325268 COOSN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(sc4c3)N(C)C)nc2)CC1 InChI=1S/C24H27FN8O2S2/c1-31(2)24-28-19-6-5-17(12-20(19)36-24)22-18(25)14-27-23(30-22)29-21-7-4-16(13-26-21)15-32-8-10-33(11-9-32)37-35-34-3/h4-7,12-14H,8-11,15H2,1-3H3,(H,26,27,29,30) CWJYPTXNZHHIRN-UHFFFAOYSA-N 621000 6-(5-fluoro-2-((5-((4-(methanesulfonyl)piperazine-1 -yl)methyl)pyridine-2-yl)amino)pyrimidine-4-yl)-N,N-dimethylbenzothiazole-2-amine::US20230303553, Example 37 Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621000&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073884 485228162 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325269 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4ncsc4c3)nc2)CC1 InChI=1S/C23H24FN7S/c1-2-30-7-9-31(10-8-30)14-16-3-6-21(25-12-16)28-23-26-13-18(24)22(29-23)17-4-5-19-20(11-17)32-15-27-19/h3-6,11-13,15H,2,7-10,14H2,1H3,(H,25,26,28,29) RZIGIEYHMMFZMB-UHFFFAOYSA-N 621001 4-(benzothiazole-6-yl)-N-(5-((4-ethylpiperazine-1-yl)methyl)pyridine-2-yl)-5-fluoropyrimidine-2-amine::US20230303553, Example 2 Cyclin-dependent kinase 6 Homo sapiens 244 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621001&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073850 485228163 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325270 CC(C)(C)OC(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(NC5CCCC5)sc4c3)nc2)CC1 InChI=1S/C31H37FN8O2S/c1-31(2,3)42-30(41)40-14-12-39(13-15-40)19-20-8-11-26(33-17-20)37-28-34-18-23(32)27(38-28)21-9-10-24-25(16-21)43-29(36-24)35-22-6-4-5-7-22/h8-11,16-18,22H,4-7,12-15,19H2,1-3H3,(H,35,36)(H,33,34,37,38) NKOHTLXWFXTQCS-UHFFFAOYSA-N 621002 US20230303553, Example 20::tert-butyl 4-((6-((4-(2-(cyclopentylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621002&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073848 485228164 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325271 CCOC(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(sc4c3)N(C)C)nc2)CC1 InChI=1S/C26H29FN8O2S/c1-4-37-26(36)35-11-9-34(10-12-35)16-17-5-8-22(28-14-17)31-24-29-15-19(27)23(32-24)18-6-7-20-21(13-18)38-25(30-20)33(2)3/h5-8,13-15H,4,9-12,16H2,1-3H3,(H,28,29,31,32) CQRJFCYNOPLJPG-UHFFFAOYSA-N 621003 US20230303553, Example 38::ethyl 4-((6-((4-(2-(dimethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens >1000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621003&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073854 485228165 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325272 CC(C)(C)OC(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4ncsc4c3)nc2)CC1 InChI=1S/C26H28FN7O2S/c1-26(2,3)36-25(35)34-10-8-33(9-11-34)15-17-4-7-22(28-13-17)31-24-29-14-19(27)23(32-24)18-5-6-20-21(12-18)37-16-30-20/h4-7,12-14,16H,8-11,15H2,1-3H3,(H,28,29,31,32) KTFCFKOULDVYHZ-UHFFFAOYSA-N 621004 US20230303553, Example 3::tert-butyl 4-((6-((4-(benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens 272 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621004&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073921 485228166 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325273 Fc1cnc(Nc2ccc(CN3CCNCC3)cn2)nc1-c1ccc2nc(NC3CCCC3)sc2c1 InChI=1S/C26H29FN8S/c27-20-15-30-25(33-23-8-5-17(14-29-23)16-35-11-9-28-10-12-35)34-24(20)18-6-7-21-22(13-18)36-26(32-21)31-19-3-1-2-4-19/h5-8,13-15,19,28H,1-4,9-12,16H2,(H,31,32)(H,29,30,33,34) AUSDRYPYNGBOOX-UHFFFAOYSA-N 621005 N-cyclopentyl-6-(5-fluoro-2-((5-(piperazine-1 -ylmethyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine hydrochloride::US20230303553, Example 21 Cyclin-dependent kinase 6 Homo sapiens 201 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621005&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073900 485228167 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325274 CC(C)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(sc3c2)N(C)C)nc1 InChI=1S/C26H29FN8OS/c1-16(2)34-9-11-35(12-10-34)24(36)18-6-8-22(28-14-18)31-25-29-15-19(27)23(32-25)17-5-7-20-21(13-17)37-26(30-20)33(3)4/h5-8,13-16H,9-12H2,1-4H3,(H,28,29,31,32) UKLWPHGHSYZRHP-UHFFFAOYSA-N 621006 (6-((4-(2-(dimethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(4-isopropylpiperazine-1-yl)ketone::US20230303553, Example 39 Cyclin-dependent kinase 6 Homo sapiens 57.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621006&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073916 485228168 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325275 Fc1cnc(Nc2ccc(CN3CCNCC3)cn2)nc1-c1ccc2ncsc2c1 InChI=1S/C21H20FN7S/c22-16-11-25-21(28-20(16)15-2-3-17-18(9-15)30-13-26-17)27-19-4-1-14(10-24-19)12-29-7-5-23-6-8-29/h1-4,9-11,13,23H,5-8,12H2,(H,24,25,27,28) OMBKCNXYXFKPAO-UHFFFAOYSA-N 621007 4-(benzothiazole-6-yl)-5-fluoro-N-(5-(piperazine-1-ylmethyl)pyridine-2-yl)pyrimidine-2-amine hydrochloride::US20230303553, Example 4 Cyclin-dependent kinase 6 Homo sapiens 268 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621007&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073859 485228169 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325276 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(NC4CCCC4)sc3c2)nc1 InChI=1S/C31H35FN8O3S/c1-31(2,3)43-30(42)40-14-12-39(13-15-40)27(41)20-9-11-25(33-17-20)37-28-34-18-22(32)26(38-28)19-8-10-23-24(16-19)44-29(36-23)35-21-6-4-5-7-21/h8-11,16-18,21H,4-7,12-15H2,1-3H3,(H,35,36)(H,33,34,37,38) ACCOQUITGBZNIB-UHFFFAOYSA-N 621008 US20230303553, Example 22::tert-butyl 4-(6-((4-(2-(cyclopentylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)nicotinoyl)piperazine-1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621008&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073865 485228170 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325277 CN(C)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C27H31FN8O2S/c1-27(2,3)38-26(37)36-12-10-35(11-13-36)18-7-9-22(29-15-18)32-24-30-16-19(28)23(33-24)17-6-8-20-21(14-17)39-25(31-20)34(4)5/h6-9,14-16H,10-13H2,1-5H3,(H,29,30,32,33) HPJNRYOJHLZCRY-UHFFFAOYSA-N 621009 US20230303553, Example 40::tert-butyl 4-(6-((4-(2-(dimethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl) amino)pyridine-3-yl)piperazine- 1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens >1000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621009&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073849 485228171 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325278 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncsc3c2)nc1 InChI=1S/C26H26FN7O3S/c1-26(2,3)37-25(36)34-10-8-33(9-11-34)23(35)17-5-7-21(28-13-17)31-24-29-14-18(27)22(32-24)16-4-6-19-20(12-16)38-15-30-19/h4-7,12-15H,8-11H2,1-3H3,(H,28,29,31,32) GTVWYIASBVPCEA-UHFFFAOYSA-N 621010 US20230303553, Example 5::tert-butyl 4-(6-((4-(benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)nicotinoyl)piperazine-1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens 111 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621010&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073893 485228172 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325279 Fc1cnc(Nc2ccc(cn2)C(=O)N2CCNCC2)nc1-c1ccc2nc(NC3CCCC3)sc2c1 InChI=1S/C26H27FN8OS/c27-19-15-30-25(33-22-8-6-17(14-29-22)24(36)35-11-9-28-10-12-35)34-23(19)16-5-7-20-21(13-16)37-26(32-20)31-18-3-1-2-4-18/h5-8,13-15,18,28H,1-4,9-12H2,(H,31,32)(H,29,30,33,34) ZXNKLLQATJHCGU-UHFFFAOYSA-N 621011 (6-((4-(2-(cyclopentylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(piperazine-1-yl)ketone hydrochloride::US20230303553, Example 23 Cyclin-dependent kinase 6 Homo sapiens 116 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621011&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073861 485228173 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325280 CN(C)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C22H23FN8S/c1-30(2)22-27-17-5-3-14(11-18(17)32-22)20-16(23)13-26-21(29-20)28-19-6-4-15(12-25-19)31-9-7-24-8-10-31/h3-6,11-13,24H,7-10H2,1-2H3,(H,25,26,28,29) XKSYBFKDFGVVSG-UHFFFAOYSA-N 621012 6-(5-fluoro-2-((5-(piperazine-1-yl)pyridine-2-yl)amino)pyrimidine-4-yl)-N,N-dimethylbenzothiazole-2-amine hydrochloride::US20230303553, Example 41 Cyclin-dependent kinase 6 Homo sapiens 61.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621012&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073853 485228174 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325281 Fc1cnc(Nc2ccc(cn2)C(=O)N2CCNCC2)nc1-c1ccc2ncsc2c1 InChI=1S/C21H18FN7OS/c22-15-11-25-21(28-19(15)13-1-3-16-17(9-13)31-12-26-16)27-18-4-2-14(10-24-18)20(30)29-7-5-23-6-8-29/h1-4,9-12,23H,5-8H2,(H,24,25,27,28) GLXOBAUWZZUWAU-UHFFFAOYSA-N 621013 6-((4-(benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(piperazine-1-yl)ketone hydrochloride::US20230303553, Example 6 Cyclin-dependent kinase 6 Homo sapiens 104 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621013&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073894 485228175 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325282 CCOC(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(NC5CCCC5)sc4c3)nc2)CC1 InChI=1S/C29H33FN8O2S/c1-2-40-29(39)38-13-11-37(12-14-38)18-19-7-10-25(31-16-19)35-27-32-17-22(30)26(36-27)20-8-9-23-24(15-20)41-28(34-23)33-21-5-3-4-6-21/h7-10,15-17,21H,2-6,11-14,18H2,1H3,(H,33,34)(H,31,32,35,36) NWLYHXPRUONCMU-UHFFFAOYSA-N 621014 US20230303553, Example 24::ethyl 4-((6-((4-(2-(cyclopentylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621014&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073891 485228176 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325283 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC)CC2)ncc1F InChI=1S/C27H31FN8OS/c1-4-34-11-13-36(14-12-34)25(37)19-8-10-23(29-16-19)32-26-30-17-20(28)24(33-26)18-7-9-21-22(15-18)38-27(31-21)35(5-2)6-3/h7-10,15-17H,4-6,11-14H2,1-3H3,(H,29,30,32,33) NVJVPUYRSSDOPO-UHFFFAOYSA-N 621015 (6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(4-ethylpiperazine-1-yl)ketone::US20230303553, Example 42 Cyclin-dependent kinase 6 Homo sapiens 14.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621015&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073912 485228177 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325284 CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncsc3c2)nc1 InChI=1S/C25H26FN7O2S/c1-25(2,3)35-24(34)33-10-8-32(9-11-33)17-5-7-21(27-13-17)30-23-28-14-18(26)22(31-23)16-4-6-19-20(12-16)36-15-29-19/h4-7,12-15H,8-11H2,1-3H3,(H,27,28,30,31) SDNANHXHIIGVKI-UHFFFAOYSA-N 621016 US20230303553, Example 7::tert-butyl 4-(6-((4-(benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621016&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073857 485228178 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325285 COOSN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(NC5CCCC5)sc4c3)nc2)CC1 InChI=1S/C27H31FN8O2S2/c1-37-38-40-36-12-10-35(11-13-36)17-18-6-9-24(29-15-18)33-26-30-16-21(28)25(34-26)19-7-8-22-23(14-19)39-27(32-22)31-20-4-2-3-5-20/h6-9,14-16,20H,2-5,10-13,17H2,1H3,(H,31,32)(H,29,30,33,34) GFJZUPIPUKEDGK-UHFFFAOYSA-N 621017 N-cyclopentyl-6-(5-fluoro-2-((5-((4-(methanesulfonyl)piperazine-1-yl)methyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine::US20230303553, Example 25 Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621017&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073878 485228179 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325286 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCN(CC)CC3)cn2)ncc1F InChI=1S/C27H33FN8S/c1-4-34-11-13-35(14-12-34)18-19-7-10-24(29-16-19)32-26-30-17-21(28)25(33-26)20-8-9-22-23(15-20)37-27(31-22)36(5-2)6-3/h7-10,15-17H,4-6,11-14,18H2,1-3H3,(H,29,30,32,33) HIDZIHZHRJJHIB-UHFFFAOYSA-N 621018 N,N-diethyl-6-(2-((5-((4-ethylpiperazine-1-yl)methyl)pyridine-2-yl)amino)-5-fluoropyrimidine-4-ylbenzothiazole-2-amine::US20230303553, Example 43 Cyclin-dependent kinase 6 Homo sapiens 15.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621018&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073881 485228180 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325287 Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1ccc2ncsc2c1 InChI=1S/C20H18FN7S/c21-15-11-24-20(27-19(15)13-1-3-16-17(9-13)29-12-25-16)26-18-4-2-14(10-23-18)28-7-5-22-6-8-28/h1-4,9-12,22H,5-8H2,(H,23,24,26,27) RRJNXBNVQSVJBA-UHFFFAOYSA-N 621019 4-(benzothiazole-6-yl)-5-fluoro-N-(5-(piperazine-1-yl)pyridine-2-yl)pyrimidine-2-amine hydrochloride::US20230303553, Example 8 Cyclin-dependent kinase 6 Homo sapiens 129 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621019&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 156779616 485228181 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325288 CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(NC4CCCC4)sc3c2)nc1 InChI=1S/C30H35FN8O2S/c1-30(2,3)41-29(40)39-14-12-38(13-15-39)21-9-11-25(32-17-21)36-27-33-18-22(31)26(37-27)19-8-10-23-24(16-19)42-28(35-23)34-20-6-4-5-7-20/h8-11,16-18,20H,4-7,12-15H2,1-3H3,(H,34,35)(H,32,33,36,37) XWBPXBNSMOXMLC-UHFFFAOYSA-N 621020 US20230303553, Example 26::tert-butyl 4-(6-((4-(2-(cyclopentylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens >1000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621020&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073887 485228182 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325289 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cn2)ncc1F InChI=1S/C30H37FN8O2S/c1-6-38(7-2)28-34-23-10-9-21(16-24(23)42-28)26-22(31)18-33-27(36-26)35-25-11-8-20(17-32-25)19-37-12-14-39(15-13-37)29(40)41-30(3,4)5/h8-11,16-18H,6-7,12-15,19H2,1-5H3,(H,32,33,35,36) LMFRFFRCLFOZOU-UHFFFAOYSA-N 621021 US20230303553, Example 44::tert-butyl 4-((6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens >1000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621021&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073877 485228183 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325290 COOSN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4ncsc4c3)nc2)CC1 InChI=1S/C22H22FN7O2S2/c1-31-32-34-30-8-6-29(7-9-30)13-15-2-5-20(24-11-15)27-22-25-12-17(23)21(28-22)16-3-4-18-19(10-16)33-14-26-18/h2-5,10-12,14H,6-9,13H2,1H3,(H,24,25,27,28) UMRHEBGPWPQSIH-UHFFFAOYSA-N 621022 4-(benzothiazole-6-yl)-5-fluoro-N-(5-((4-(methanesulfonyl)piperazine-1 -yl)methyl)pyridine-2-yl)pyrimidine-2-amine::US20230303553, Example 9 Cyclin-dependent kinase 6 Homo sapiens >1000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621022&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073868 485228184 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325291 Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1ccc2nc(NC3CCCC3)sc2c1 InChI=1S/C25H27FN8S/c26-19-15-29-24(32-22-8-6-18(14-28-22)34-11-9-27-10-12-34)33-23(19)16-5-7-20-21(13-16)35-25(31-20)30-17-3-1-2-4-17/h5-8,13-15,17,27H,1-4,9-12H2,(H,30,31)(H,28,29,32,33) NZVIEGVPMXNSJT-UHFFFAOYSA-N 621023 N-cyclopentyl-6-(5-fluoro-2-((5-(piperazine-1 -yl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine hydrochloride::US20230303553, Example 27 Cyclin-dependent kinase 6 Homo sapiens 139 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621023&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073847 485228185 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325292 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F InChI=1S/C25H29FN8S/c1-3-34(4-2)25-30-20-7-6-18(13-21(20)35-25)23-19(26)15-29-24(32-23)31-22-8-5-17(14-28-22)16-33-11-9-27-10-12-33/h5-8,13-15,27H,3-4,9-12,16H2,1-2H3,(H,28,29,31,32) ONCJKEZPQVEATH-UHFFFAOYSA-N 621024 N,N-diethyl-6-(5-fluoro-2-((5-(piperazine-1 -ylmethyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine hydrochloride::US20230303553, Example 45 Cyclin-dependent kinase 6 Homo sapiens 45.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621024&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073855 485228186 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325293 CCOC(=O)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3ncsc3c2)nc1 InChI=1S/C24H22FN7O3S/c1-2-35-24(34)32-9-7-31(8-10-32)22(33)16-4-6-20(26-12-16)29-23-27-13-17(25)21(30-23)15-3-5-18-19(11-15)36-14-28-18/h3-6,11-14H,2,7-10H2,1H3,(H,26,27,29,30) VEBFWIMAFJVQSK-UHFFFAOYSA-N 621025 US20230303553, Example 10::ethyl 4-((6-((4-(benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens 169 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621025&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073895 485228187 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325294 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(NC5CCCC5)sc4c3)nc2)CC1 InChI=1S/C29H35FN8S/c1-19(2)38-13-11-37(12-14-38)18-20-7-10-26(31-16-20)35-28-32-17-23(30)27(36-28)21-8-9-24-25(15-21)39-29(34-24)33-22-5-3-4-6-22/h7-10,15-17,19,22H,3-6,11-14,18H2,1-2H3,(H,33,34)(H,31,32,35,36) JYRRTOFZIGEMAN-UHFFFAOYSA-N 621026 N-cyclopentyl-6-(5-fluoro-2-((5-((4-isopropylpiperazine-1-yl)methyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine::US20230303553, Example 28 Cyclin-dependent kinase 6 Homo sapiens 132 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621026&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073906 485228188 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325295 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C30H35FN8O3S/c1-6-37(7-2)28-34-22-10-8-19(16-23(22)43-28)25-21(31)18-33-27(36-25)35-24-11-9-20(17-32-24)26(40)38-12-14-39(15-13-38)29(41)42-30(3,4)5/h8-11,16-18H,6-7,12-15H2,1-5H3,(H,32,33,35,36) NPQSOFKMVBBVFF-UHFFFAOYSA-N 621027 US20230303553, Example 46::tert-butyl 4-(6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)nicotinoyl)piperazine-1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens 443 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621027&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073879 485228189 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325296 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4ncsc4c3)nc2)CC1 InChI=1S/C24H26FN7S/c1-16(2)32-9-7-31(8-10-32)14-17-3-6-22(26-12-17)29-24-27-13-19(25)23(30-24)18-4-5-20-21(11-18)33-15-28-20/h3-6,11-13,15-16H,7-10,14H2,1-2H3,(H,26,27,29,30) MCHFBGTXGSLCLO-UHFFFAOYSA-N 621028 4-(benzothiazole-6-yl)-5-fluoro-N-(5-((4-isopropylpiperazine-1-yl)methyl)pyridine-2-yl)pyrimidine-2-amine::US20230303553, Example 11 Cyclin-dependent kinase 6 Homo sapiens 175 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621028&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073896 485228190 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325297 CC(C)N1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(NC4CCCC4)sc3c2)nc1 InChI=1S/C29H33FN8OS/c1-18(2)37-11-13-38(14-12-37)27(39)20-8-10-25(31-16-20)35-28-32-17-22(30)26(36-28)19-7-9-23-24(15-19)40-29(34-23)33-21-5-3-4-6-21/h7-10,15-18,21H,3-6,11-14H2,1-2H3,(H,33,34)(H,31,32,35,36) OVRDWLJZSQZCBW-UHFFFAOYSA-N 621029 (6-((4-(2-(cyclopentylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(4-isopropylpiperazine-1-yl)ketone::US20230303553, Example 29 Cyclin-dependent kinase 6 Homo sapiens 74.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621029&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073870 485228191 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325298 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCNCC2)ncc1F InChI=1S/C25H27FN8OS/c1-3-33(4-2)25-30-19-7-5-16(13-20(19)36-25)22-18(26)15-29-24(32-22)31-21-8-6-17(14-28-21)23(35)34-11-9-27-10-12-34/h5-8,13-15,27H,3-4,9-12H2,1-2H3,(H,28,29,31,32) QULVCQWDONFUCP-UHFFFAOYSA-N 621030 (6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(piperazine-1-yl)ketonehydrochloride::US20230303553, Example 47 Cyclin-dependent kinase 6 Homo sapiens 39.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621030&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073897 485228192 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325299 CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(C)sc3c2)nc1 InChI=1S/C24H24FN7OS/c1-3-31-8-10-32(11-9-31)23(33)17-5-7-21(26-13-17)29-24-27-14-18(25)22(30-24)16-4-6-19-20(12-16)34-15(2)28-19/h4-7,12-14H,3,8-11H2,1-2H3,(H,26,27,29,30) PZOPDPMHBNVSSS-UHFFFAOYSA-N 621031 (4-ethylpiperazine-1-yl)(6-((5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimidine-2-yl)amino)pyridine-3-yl)ketone::US20230303553, Example 12 Cyclin-dependent kinase 6 Homo sapiens 127 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621031&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073858 485228193 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325300 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(sc4c3)N(C)C)nc2)CC1 InChI=1S/C25H29FN8S/c1-4-33-9-11-34(12-10-33)16-17-5-8-22(27-14-17)30-24-28-15-19(26)23(31-24)18-6-7-20-21(13-18)35-25(29-20)32(2)3/h5-8,13-15H,4,9-12,16H2,1-3H3,(H,27,28,30,31) LEOZMLQREDIKAH-UHFFFAOYSA-N 621032 6-(2-((5-((4-ethylpiperazine-1-yl)methyl)pyridine-2-yl)amino)-5-fluoropyrimidine-4-yl)-N,N-dimethylbenzothiazole-2-amine::US20230303553, Example 30 Cyclin-dependent kinase 6 Homo sapiens 254 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621032&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073873 485228194 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325301 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCN(CC3)SOOC)cn2)ncc1F InChI=1S/C26H31FN8O2S2/c1-4-34(5-2)26-30-21-8-7-19(14-22(21)38-26)24-20(27)16-29-25(32-24)31-23-9-6-18(15-28-23)17-33-10-12-35(13-11-33)39-37-36-3/h6-9,14-16H,4-5,10-13,17H2,1-3H3,(H,28,29,31,32) STIWUJBLAUUJGS-UHFFFAOYSA-N 621033 N,N-diethyl-6-(5-fluoro-2-((5-((4-(methanesulfonyl)piperazine-1 -yl)methyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine::US20230303553, Example 48 Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621033&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073863 485228195 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325302 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(C)sc4c3)nc2)CC1 InChI=1S/C24H26FN7S/c1-3-31-8-10-32(11-9-31)15-17-4-7-22(26-13-17)29-24-27-14-19(25)23(30-24)18-5-6-20-21(12-18)33-16(2)28-20/h4-7,12-14H,3,8-11,15H2,1-2H3,(H,26,27,29,30) CWGKHYILSMYODL-UHFFFAOYSA-N 621034 N-(5-((4-ethylpiperazine-1-yl)methyl)pyridine-2-yl)-5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimidine-2-amine::US20230303553, Example 13 Cyclin-dependent kinase 6 Homo sapiens 210 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621034&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073898 485228196 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325303 CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(sc3c2)N(C)C)nc1 InChI=1S/C25H27FN8OS/c1-4-33-9-11-34(12-10-33)23(35)17-6-8-21(27-14-17)30-24-28-15-18(26)22(31-24)16-5-7-19-20(13-16)36-25(29-19)32(2)3/h5-8,13-15H,4,9-12H2,1-3H3,(H,27,28,30,31) AWBAKFAKVVKANT-UHFFFAOYSA-N 621035 (6-((4-(2-(dimethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(4-ethylpiperazine-1-yl)ketone::US20230303553, Example 31 Cyclin-dependent kinase 6 Homo sapiens 18.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621035&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search YK2 7EJV 163183800 485228197 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325304 CCOC(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(sc4c3)N(CC)CC)nc2)CC1 InChI=1S/C28H33FN8O2S/c1-4-36(5-2)27-32-22-9-8-20(15-23(22)40-27)25-21(29)17-31-26(34-25)33-24-10-7-19(16-30-24)18-35-11-13-37(14-12-35)28(38)39-6-3/h7-10,15-17H,4-6,11-14,18H2,1-3H3,(H,30,31,33,34) ARDHEWHWMBSDDO-UHFFFAOYSA-N 621036 US20230303553, Example 49::ethyl 4-((6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621036&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073892 485228198 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325305 Cc1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cn2)ncc1F InChI=1S/C27H30FN7O2S/c1-17-31-21-7-6-19(13-22(21)38-17)24-20(28)15-30-25(33-24)32-23-8-5-18(14-29-23)16-34-9-11-35(12-10-34)26(36)37-27(2,3)4/h5-8,13-15H,9-12,16H2,1-4H3,(H,29,30,32,33) RQIJNGZJGSJUAD-UHFFFAOYSA-N 621037 US20230303553, Example 14::tert-butyl 4-((6-((5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621037&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073883 485228199 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325306 CN(C)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cn2)ncc1F InChI=1S/C28H33FN8O2S/c1-28(2,3)39-27(38)37-12-10-36(11-13-37)17-18-6-9-23(30-15-18)33-25-31-16-20(29)24(34-25)19-7-8-21-22(14-19)40-26(32-21)35(4)5/h6-9,14-16H,10-13,17H2,1-5H3,(H,30,31,33,34) MHKUDBFCGPMFET-UHFFFAOYSA-N 621038 US20230303553, Example 32::tert-butyl 4-((6-((4-(2-(dimethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621038&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073852 485228200 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325307 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCN(CC3)C(C)C)cn2)ncc1F InChI=1S/C28H35FN8S/c1-5-36(6-2)28-32-23-9-8-21(15-24(23)38-28)26-22(29)17-31-27(34-26)33-25-10-7-20(16-30-25)18-35-11-13-37(14-12-35)19(3)4/h7-10,15-17,19H,5-6,11-14,18H2,1-4H3,(H,30,31,33,34) XZZFQEGIEAZRGP-UHFFFAOYSA-N 621039 N,N-diethyl-6-5-fluoro-2-((5-((4-isopropylpiperazine-1-yl)methyl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine::US20230303553, Example 50 Cyclin-dependent kinase 6 Homo sapiens 31.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621039&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073915 485228201 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325308 Cc1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F InChI=1S/C22H22FN7S/c1-14-27-18-4-3-16(10-19(18)31-14)21-17(23)12-26-22(29-21)28-20-5-2-15(11-25-20)13-30-8-6-24-7-9-30/h2-5,10-12,24H,6-9,13H2,1H3,(H,25,26,28,29) BXPPINFBXDOAPI-UHFFFAOYSA-N 621040 5-fluoro-4-(2-methylbenzothiazole-6-yl)-N-(5-(piperazine-1 -ylmethyl)pyridine-2-yl)pyrimidine-2-amine hydrochloride::US20230303553, Example 15 Cyclin-dependent kinase 6 Homo sapiens 464 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621040&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073907 485228202 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325309 CN(C)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F InChI=1S/C23H25FN8S/c1-31(2)23-28-18-5-4-16(11-19(18)33-23)21-17(24)13-27-22(30-21)29-20-6-3-15(12-26-20)14-32-9-7-25-8-10-32/h3-6,11-13,25H,7-10,14H2,1-2H3,(H,26,27,29,30) RXPRUWAATMHULG-UHFFFAOYSA-N 621041 6-(5-fluoro-2-((5-(piperazine-1-ylmethyl)pyridine-2-yl)amino)pyrimidine-4-yl)-N,N-dimethylbenzothiazole-2-amine hydrochloride::US20230303553, Example 33 Cyclin-dependent kinase 6 Homo sapiens 59.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621041&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073885 485228203 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325310 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(C)C)ncc1F InChI=1S/C28H33FN8OS/c1-5-35(6-2)28-32-22-9-7-19(15-23(22)39-28)25-21(29)17-31-27(34-25)33-24-10-8-20(16-30-24)26(38)37-13-11-36(12-14-37)18(3)4/h7-10,15-18H,5-6,11-14H2,1-4H3,(H,30,31,33,34) QXLHPZGOJNRMDZ-UHFFFAOYSA-N 621042 (6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(4-isopropylpiperazine-1-yl)ketone::US20230303553, Example 51 Cyclin-dependent kinase 6 Homo sapiens 8.00 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621042&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073871 485228204 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325311 Cc1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C27H28FN7O3S/c1-16-31-20-7-5-17(13-21(20)39-16)23-19(28)15-30-25(33-23)32-22-8-6-18(14-29-22)24(36)34-9-11-35(12-10-34)26(37)38-27(2,3)4/h5-8,13-15H,9-12H2,1-4H3,(H,29,30,32,33) BMGAEQFSDVAGHR-UHFFFAOYSA-N 621043 US20230303553, Example 16::tert-butyl 4-(6-((5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimidine-2-yl)amino)nicotinoyl)piperazine-1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens 86.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621043&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073904 485228205 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325312 CN(C)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C28H31FN8O3S/c1-28(2,3)40-27(39)37-12-10-36(11-13-37)24(38)18-7-9-22(30-15-18)33-25-31-16-19(29)23(34-25)17-6-8-20-21(14-17)41-26(32-20)35(4)5/h6-9,14-16H,10-13H2,1-5H3,(H,30,31,33,34) GYKCSCSHNUSDKM-UHFFFAOYSA-N 621044 US20230303553, Example 34::tert-butyl 4-(6-((4-(2-(dimethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)nicotinoyl)piperazine-1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621044&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073851 485228206 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325313 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)N2CCN(CC2)C(=O)OC(C)(C)C)ncc1F InChI=1S/C29H35FN8O2S/c1-6-36(7-2)27-33-22-10-8-19(16-23(22)41-27)25-21(30)18-32-26(35-25)34-24-11-9-20(17-31-24)37-12-14-38(15-13-37)28(39)40-29(3,4)5/h8-11,16-18H,6-7,12-15H2,1-5H3,(H,31,32,34,35) MVSOCCKVJJXAJQ-UHFFFAOYSA-N 621045 US20230303553, Example 52::tert-butyl 4-(6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl) amino)pyridine-3-yl)piperazine- 1 -carboxylate Cyclin-dependent kinase 6 Homo sapiens >10000 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621045&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073914 485228207 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325314 Cc1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCNCC2)ncc1F InChI=1S/C22H20FN7OS/c1-13-27-17-4-2-14(10-18(17)32-13)20-16(23)12-26-22(29-20)28-19-5-3-15(11-25-19)21(31)30-8-6-24-7-9-30/h2-5,10-12,24H,6-9H2,1H3,(H,25,26,28,29) UYRUSUBNRZEGRJ-UHFFFAOYSA-N 621046 (6-((5-fluoro-4-(2-methylbenzothiazole-6-yl)pyrimidine-2-yl)amino)pyridine-3-yl)(piperazine-1-yl)ketone hydrochloride::US20230303553, Example 17 Cyclin-dependent kinase 6 Homo sapiens 93.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621046&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073856 485228208 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325315 CN(C)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)C(=O)N2CCNCC2)ncc1F InChI=1S/C23H23FN8OS/c1-31(2)23-28-17-5-3-14(11-18(17)34-23)20-16(24)13-27-22(30-20)29-19-6-4-15(12-26-19)21(33)32-9-7-25-8-10-32/h3-6,11-13,25H,7-10H2,1-2H3,(H,26,27,29,30) OSFWNAAFYPRMNV-UHFFFAOYSA-N 621047 (6-((4-(2-(dimethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(piperazine-1-yl)ketone hydrochloride::US20230303553, Example 35 Cyclin-dependent kinase 6 Homo sapiens 41.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621047&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073890 485228209 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325316 CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C24H27FN8S/c1-3-32(4-2)24-29-19-7-5-16(13-20(19)34-24)22-18(25)15-28-23(31-22)30-21-8-6-17(14-27-21)33-11-9-26-10-12-33/h5-8,13-15,26H,3-4,9-12H2,1-2H3,(H,27,28,30,31) IQPGVUQARGVQGU-UHFFFAOYSA-N 621048 N,N-diethyl-6-(5-fluoro-2-((5-(piperazine-1 -yl)pyridine-2-yl)amino)pyrimidine-4-yl)benzothiazole-2-amine hydrochloride::US20230303553, Example 53 Cyclin-dependent kinase 6 Homo sapiens 23.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621048&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073867 485228210 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325317 CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2ccc3nc(NC4CCCC4)sc3c2)nc1 InChI=1S/C28H31FN8OS/c1-2-36-11-13-37(14-12-36)26(38)19-8-10-24(30-16-19)34-27-31-17-21(29)25(35-27)18-7-9-22-23(15-18)39-28(33-22)32-20-5-3-4-6-20/h7-10,15-17,20H,2-6,11-14H2,1H3,(H,32,33)(H,30,31,34,35) QKGQVNUHCXZGQO-UHFFFAOYSA-N 621049 (6-((4-(2-(cyclopentylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)(4-ethylpiperazine-1-yl)ketone::US20230303553, Example 18 Cyclin-dependent kinase 6 Homo sapiens 90.0 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621049&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073902 485228211 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 1325318 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4nc(sc4c3)N(C)C)nc2)CC1 InChI=1S/C26H31FN8S/c1-17(2)35-11-9-34(10-12-35)16-18-5-8-23(28-14-18)31-25-29-15-20(27)24(32-25)19-6-7-21-22(13-19)36-26(30-21)33(3)4/h5-8,13-15,17H,9-12,16H2,1-4H3,(H,28,29,31,32) FZUIMPHBTDWCHW-UHFFFAOYSA-N 621050 6-(5-fluoro-2-((5-((4-isopropylpiperazine-1 -yl)methyl)pyridine-2-yl)amino)pyrimidine-4-yl)-N,N-dimethylbenzothiazole-2-amine::US20230303553, Example 36 Cyclin-dependent kinase 6 Homo sapiens 142 US Patent 10.7270/Q27D3093 US20230303553 YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621050&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 169073872 485228212 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50059063 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 6 Homo sapiens 60 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50059064 CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1Cl)C(F)(F)F InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1 MRPGRAKIAJJGMM-OCCSQVGLSA-N 50193104 CHEMBL3905910 Cyclin-dependent kinase 6 Homo sapiens 210 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193104&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 67409219 375076114 CHEMBL3905910 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50059065 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m1/s1 SCACHXWSWJBIHG-HIFRSBDPSA-N 50358213 CHEMBL1922219::US8846696, (2R3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-dependent kinase 6 Homo sapiens 6200 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358213&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 8QT 5MHQ 9842276 136962237 CHEMBL1922219 ZINC03939649 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50596025 COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1 InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22) GGQCIOOSELPMBB-UHFFFAOYSA-N 50013510 CHEMBL3263773 Cyclin-dependent kinase 6 Homo sapiens >10000 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013510&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 25104564 242058283 CHEMBL3263773 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50598329 CCC(CC)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H25N5/c1-3-11(4-2)14-10-16(19-13-6-5-12(17)9-13)21-15(20-14)7-8-18-21/h7-8,10-13,19H,3-6,9,17H2,1-2H3/t12-,13-/m0/s1 VYKCLMALANGCDF-STQMWFEESA-N 50593922 CHEMBL5199065 Cyclin-dependent kinase 6 Homo sapiens >1200 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50593922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50593922&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search VQE 8K5R 146502834 482604774 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50598330 COCCN(CC(O)=O)C(=O)C(CCCNC(N)=N)NS(=O)(=O)c1ccc2cc3OCCOc3cc2c1 InChI=1S/C23H31N5O8S/c1-34-8-7-28(14-21(29)30)22(31)18(3-2-6-26-23(24)25)27-37(32,33)17-5-4-15-12-19-20(13-16(15)11-17)36-10-9-35-19/h4-5,11-13,18,27H,2-3,6-10,14H2,1H3,(H,29,30)(H4,24,25,26) CPCGYQXBIVPIAV-UHFFFAOYSA-N 50404389 CHEMBL5285499 Cyclin-dependent kinase 6 Homo sapiens >1200 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50404389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50404389&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 44459892 163353413 CHEMBL282192 ZINC28757251 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50598835 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 167699 US9073922, 186::US9796708, Example 186 Cyclin-dependent kinase 6 Homo sapiens 298 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167699&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 90414175 312321544 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 50598836 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 354126 US9796708, Example 1358::trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexanecarboxylic acid Cyclin-dependent kinase 6 Homo sapiens 101 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354126&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 90419627 386047858 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51504981 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 10.0 ChEMBL 10.7270/Q2XP791Q 33077264 Bass, AKA; El-Zoghbi, MS; Nageeb, EM; Mohamed, MFA; Badr, M; Abuo-Rahma, GEA Menoufia University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51514469 O[C@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1)c1ccccc1 InChI=1S/C30H26N6O3/c1-2-28(38)33-23-11-8-20(9-12-23)30(39)34-29-25-15-21(10-13-26(25)35-36-29)22-14-24(17-31-16-22)32-18-27(37)19-6-4-3-5-7-19/h2-17,27,32,37H,1,18H2,(H,33,38)(H2,34,35,36,39)/t27-/m1/s1 VSTRBHWJZOVRDC-HHHXNRCGSA-N 50609501 CHEMBL5288241 Cyclin-dependent kinase 6 Homo sapiens 950 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609501&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 166176962 494499249 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51509225 CC(C)=CCC\C(C)=C\CC\C(C)=C\CC(=O)N[C@H](CP(O)(O)=O)C(O)=O InChI=1S/C19H32NO6P/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-18(21)20-17(19(22)23)13-27(24,25)26/h7,9,11,17H,5-6,8,10,12-13H2,1-4H3,(H,20,21)(H,22,23)(H2,24,25,26)/b15-9+,16-11+/t17-/m1/s1 CKUHCKCWOOAQKN-UINNIIOQSA-N 50453718 CHEMBL5287062 Cyclin-dependent kinase 6 Homo sapiens 279 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50453718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50453718&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 10408744 225146101 CHEMBL98054 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51509167 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 6 Homo sapiens 20 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51509168 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10626107, Example Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 16 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51509169 Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 50113281 AT-7519 Cyclin-dependent kinase 6 Homo sapiens 10.0 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113281&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 104007630 DB08142 ZINC13473650 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51509170 CC(C)N1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1 InChI=1S/C26H34N8O/c1-18(2)32-10-12-33(13-11-32)20-6-7-22(27-16-20)30-25-28-15-19-14-21-24(35)29-17-26(8-4-3-5-9-26)34(21)23(19)31-25/h6-7,14-16,18H,3-5,8-13,17H2,1-2H3,(H,29,35)(H,27,28,30,31) YPJRHEKCFKOVRT-UHFFFAOYSA-N 253941 US9464092, GG::US9527857, GG Cyclin-dependent kinase 6 Homo sapiens 2.0 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=253941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=253941&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 86269224 346548274 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51526404 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(C\C=C\C(F)(F)F)CC3)nc2n(C2CCCC2)c1=O InChI=1S/C28H32F3N7O2/c1-18-22-17-33-27(35-25(22)38(20-6-3-4-7-20)26(40)24(18)19(2)39)34-23-9-8-21(16-32-23)37-14-12-36(13-15-37)11-5-10-28(29,30)31/h5,8-10,16-17,20H,3-4,6-7,11-15H2,1-2H3,(H,32,33,34,35)/b10-5+ ZIJYDOFMALQXKA-BJMVGYQFSA-N 50614148 CHEMBL5277376 Cyclin-dependent kinase 6 Homo sapiens 13 ChEMBL 10.7270/Q29Z995F 37011445 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50614148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50614148&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 171354833 494503896 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51526405 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)C=C)nc2n(C2CCCC2)c1=O InChI=1S/C27H31N7O3/c1-4-23(36)33-13-11-32(12-14-33)20-9-10-22(28-15-20)30-27-29-16-21-17(2)24(18(3)35)26(37)34(25(21)31-27)19-7-5-6-8-19/h4,9-10,15-16,19H,1,5-8,11-14H2,2-3H3,(H,28,29,30,31) ZQLILUVVXPRXLE-UHFFFAOYSA-N 50614149 CHEMBL4860767 Cyclin-dependent kinase 6 Homo sapiens 15 ChEMBL 10.7270/Q29Z995F 37011445 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50614149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50614149&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 164616499 494503897 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51526406 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)C(=C\c3ccccc3)\C#N)nc2n(C2CCCC2)c1=O InChI=1S/C34H34N8O3/c1-22-28-21-37-34(39-31(28)42(26-10-6-7-11-26)33(45)30(22)23(2)43)38-29-13-12-27(20-36-29)40-14-16-41(17-15-40)32(44)25(19-35)18-24-8-4-3-5-9-24/h3-5,8-9,12-13,18,20-21,26H,6-7,10-11,14-17H2,1-2H3,(H,36,37,38,39)/b25-18+ MCGRCAVMPSXODJ-XIEYBQDHSA-N 50614150 CHEMBL5277470 Cyclin-dependent kinase 6 Homo sapiens 19 ChEMBL 10.7270/Q29Z995F 37011445 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50614150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50614150&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 171352280 494503898 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51526407 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10626107, Example Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 6 Homo sapiens 38 ChEMBL 10.7270/Q29Z995F 37011445 Fang, L; Chu, M; Yan, C; Liu, Y; Zhao, Z Southeast University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51002130 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10626107, Example LY2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 10.0 ChEMBL 10.7270/Q2FB5754 33650861 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51002150 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::Kisqali::LEE011::Ribociclib::US10570141, Comparative Example 1::US8962630, 74 Cyclin-dependent kinase 6 Homo sapiens 39 ChEMBL 10.7270/Q2FB5754 33650861 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T 44631912 252148259 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51001818 C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2cc(C(F)F)c1=O InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1 QIEKHLDZKRQLLN-FOIQADDNSA-N 370121 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one::US10233188, Example 10::US10800783, Example 10::US11396512, Example 10 Cyclin-dependent kinase 6 Homo sapiens 0.160000 ChEMBL 10.7270/Q2FB5754 33650861 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370121&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search WG1 7KJS 134247638 402357205 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 1G3N,1JOW,1XO2,2EUF,2F2C,3NUP,3NUX,4AUA,4EZ5,4TTH,5L2I,5L2S,5L2T,6OQL,6OQO,8I0M Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51547451 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 6 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.3c00566 10.7270/Q2FX7FV6 37234044 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51565807 O=C(Nc1ccc(cc1)N1CCNCC1)c1n[nH]cc1Nc1cc(Oc2ccccc2)ncn1 InChI=1S/C24H24N8O2/c33-24(29-17-6-8-18(9-7-17)32-12-10-25-11-13-32)23-20(15-28-31-23)30-21-14-22(27-16-26-21)34-19-4-2-1-3-5-19/h1-9,14-16,25H,10-13H2,(H,28,31)(H,29,33)(H,26,27,30) RSZBDSJQRIEBFQ-UHFFFAOYSA-N 50629602 CHEMBL5401158 Cyclin-dependent kinase 6 Homo sapiens 122 ChEMBL 10.1016/j.ejmech.2023.115448 10.7270/Q2M3316G 37163951 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629602&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555825 Sc1nnc(-c2c[nH]c3ccccc23)n1\N=C\c1ccccc1 InChI=1S/C17H13N5S/c23-17-21-20-16(14-11-18-15-9-5-4-8-13(14)15)22(17)19-10-12-6-2-1-3-7-12/h1-11,18H,(H,21,23)/b19-10+ FCKWPUFNPAWKRB-VXLYETTFSA-N 50626030 CHEMBL5407831 Cyclin-dependent kinase 6 Homo sapiens 577 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626030&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555826 Sc1nnc(-c2c[nH]c3ccccc23)n1\N=C\c1ccc(Cl)cc1 InChI=1S/C17H12ClN5S/c18-12-7-5-11(6-8-12)9-20-23-16(21-22-17(23)24)14-10-19-15-4-2-1-3-13(14)15/h1-10,19H,(H,22,24)/b20-9+ OVLZNLFIVGBMBP-AWQFTUOYSA-N 50626031 CHEMBL5396524 Cyclin-dependent kinase 6 Homo sapiens 235 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626031&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555827 Oc1ccc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)cc1 InChI=1S/C17H13N5OS/c23-12-7-5-11(6-8-12)9-19-22-16(20-21-17(22)24)14-10-18-15-4-2-1-3-13(14)15/h1-10,18,23H,(H,21,24)/b19-9+ WIDICXJAMDIRRX-DJKKODMXSA-N 50626032 CHEMBL5439029 Cyclin-dependent kinase 6 Homo sapiens 817 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626032&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555828 Cc1ccc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)cc1 InChI=1S/C18H15N5S/c1-12-6-8-13(9-7-12)10-20-23-17(21-22-18(23)24)15-11-19-16-5-3-2-4-14(15)16/h2-11,19H,1H3,(H,22,24)/b20-10+ OYRHVLHXZXDTIQ-KEBDBYFISA-N 50626033 CHEMBL5411451 Cyclin-dependent kinase 6 Homo sapiens 75 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626033&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555829 Sc1nnc(-c2c[nH]c3ccccc23)n1\N=C\c1ccc(Br)cc1 InChI=1S/C17H12BrN5S/c18-12-7-5-11(6-8-12)9-20-23-16(21-22-17(23)24)14-10-19-15-4-2-1-3-13(14)15/h1-10,19H,(H,22,24)/b20-9+ OCQGVQNZFLPPRL-AWQFTUOYSA-N 50626034 CHEMBL5418155 Cyclin-dependent kinase 6 Homo sapiens 462 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626034&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555830 COc1ccc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)cc1OC InChI=1S/C19H17N5O2S/c1-25-16-8-7-12(9-17(16)26-2)10-21-24-18(22-23-19(24)27)14-11-20-15-6-4-3-5-13(14)15/h3-11,20H,1-2H3,(H,23,27)/b21-10+ FFVBCPCSHYDMLQ-UFFVCSGVSA-N 50626035 CHEMBL5411462 Cyclin-dependent kinase 6 Homo sapiens 198 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626035&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555831 Oc1cccc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)c1O InChI=1S/C17H13N5O2S/c23-14-7-3-4-10(15(14)24)8-19-22-16(20-21-17(22)25)12-9-18-13-6-2-1-5-11(12)13/h1-9,18,23-24H,(H,21,25)/b19-8+ AAEHXZQOKUICRN-UFWORHAWSA-N 50626036 CHEMBL5401495 Cyclin-dependent kinase 6 Homo sapiens 770 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626036&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555832 Oc1ccc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)c(O)c1 InChI=1S/C17H13N5O2S/c23-11-6-5-10(15(24)7-11)8-19-22-16(20-21-17(22)25)13-9-18-14-4-2-1-3-12(13)14/h1-9,18,23-24H,(H,21,25)/b19-8+ IJBUVOBMNBVHBB-UFWORHAWSA-N 50626037 CHEMBL5440583 Cyclin-dependent kinase 6 Homo sapiens 95 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626037&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555833 Sc1nnc(-c2c[nH]c3ccccc23)n1\N=C\c1ccc(Cl)cc1Cl InChI=1S/C17H11Cl2N5S/c18-11-6-5-10(14(19)7-11)8-21-24-16(22-23-17(24)25)13-9-20-15-4-2-1-3-12(13)15/h1-9,20H,(H,23,25)/b21-8+ RYMCNDJXCVWHNC-ODCIPOBUSA-N 50626038 CHEMBL5419338 Cyclin-dependent kinase 6 Homo sapiens 271 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626038&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555834 Sc1nnc(-c2c[nH]c3ccccc23)n1\N=C\c1cccc(Cl)c1 InChI=1S/C17H12ClN5S/c18-12-5-3-4-11(8-12)9-20-23-16(21-22-17(23)24)14-10-19-15-7-2-1-6-13(14)15/h1-10,19H,(H,22,24)/b20-9+ GMQHCOFGKWUFEP-AWQFTUOYSA-N 50626039 CHEMBL5437396 Cyclin-dependent kinase 6 Homo sapiens 1110 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626039&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555835 Sc1nnc(-c2c[nH]c3ccccc23)n1\N=C\c1cccc(Br)c1 InChI=1S/C17H12BrN5S/c18-12-5-3-4-11(8-12)9-20-23-16(21-22-17(23)24)14-10-19-15-7-2-1-6-13(14)15/h1-10,19H,(H,22,24)/b20-9+ ZAEJFWCQZAIGKP-AWQFTUOYSA-N 50626040 CHEMBL5426856 Cyclin-dependent kinase 6 Homo sapiens 146 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626040&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555836 COc1ccc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)cc1 InChI=1S/C18H15N5OS/c1-24-13-8-6-12(7-9-13)10-20-23-17(21-22-18(23)25)15-11-19-16-5-3-2-4-14(15)16/h2-11,19H,1H3,(H,22,25)/b20-10+ UCSSXRJZMVWANS-KEBDBYFISA-N 50626041 CHEMBL5431823 Cyclin-dependent kinase 6 Homo sapiens 574 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626041&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555837 COc1cc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)cc(OC)c1OC InChI=1S/C20H19N5O3S/c1-26-16-8-12(9-17(27-2)18(16)28-3)10-22-25-19(23-24-20(25)29)14-11-21-15-7-5-4-6-13(14)15/h4-11,21H,1-3H3,(H,24,29)/b22-10+ HNUMRWMKXMAWTC-LSHDLFTRSA-N 50626042 CHEMBL5401951 Cyclin-dependent kinase 6 Homo sapiens 200 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626042&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555838 COc1cccc(\C=N\n2c(S)nnc2-c2c[nH]c3ccccc23)c1 InChI=1S/C18H15N5OS/c1-24-13-6-4-5-12(9-13)10-20-23-17(21-22-18(23)25)15-11-19-16-8-3-2-7-14(15)16/h2-11,19H,1H3,(H,22,25)/b20-10+ LFSZPSGSJLSCLK-KEBDBYFISA-N 50626043 CHEMBL5421064 Cyclin-dependent kinase 6 Homo sapiens 1108 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626043&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555839 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US11958831, Example Staurosporine::US20240002365, Compound staurosporine::US20240254124, Compound Staurosporine::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-dependent kinase 6 Homo sapiens 402 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51555840 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10626107, Example LY2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 6 Homo sapiens 26 ChEMBL 10.1039/d3md00524k 10.7270/Q29W0KXH 38283222 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51554972 Cn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1 InChI=1S/C21H20Cl2N10O/c1-31-10-12(8-26-31)33-11-25-18-19(29-21(30-20(18)33)32-2-4-34-5-3-32)24-9-17-27-15-6-13(22)14(23)7-16(15)28-17/h6-8,10-11H,2-5,9H2,1H3,(H,27,28)(H,24,29,30) FSELUFUYNUNZKD-UHFFFAOYSA-N 50584000 CHEMBL4877117 Cyclin-dependent kinase 6 Homo sapiens 5100 ChEMBL 10.1039/d3md00004d 10.7270/Q25D8X7N 37731700 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584000&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search RMF 8BU5,9FMR,8P81 139600338 476020087 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51565803 CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1 InChI=1S/C22H25N9O/c1-30-8-10-31(11-9-30)13-15-2-4-16(5-3-15)27-22(32)19-18(12-26-29-19)28-21-17-6-7-23-20(17)24-14-25-21/h2-7,12,14H,8-11,13H2,1H3,(H,26,29)(H,27,32)(H2,23,24,25,28) VXLAKHWYGRKCGI-UHFFFAOYSA-N 50270304 CHEMBL4077071 Cyclin-dependent kinase 6 Homo sapiens 2.0 ChEMBL 10.1016/j.ejmech.2023.115448 10.7270/Q2M3316G 37163951 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50270304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50270304&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 72195175 404961850 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51565804 CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ccncn3)cc2)CC1 InChI=1S/C20H24N8O/c1-27-8-10-28(11-9-27)13-15-2-4-16(5-3-15)24-20(29)19-17(12-23-26-19)25-18-6-7-21-14-22-18/h2-7,12,14H,8-11,13H2,1H3,(H,23,26)(H,24,29)(H,21,22,25) QGGLESNNYLSYEA-UHFFFAOYSA-N 50629587 CHEMBL5399420 Cyclin-dependent kinase 6 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2023.115448 10.7270/Q2M3316G 37163951 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629587&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51565805 O=C(Nc1ccc(cc1)N1CCNCC1)c1n[nH]cc1Nc1cc(ncn1)C1CC1 InChI=1S/C21H24N8O/c30-21(26-15-3-5-16(6-4-15)29-9-7-22-8-10-29)20-18(12-25-28-20)27-19-11-17(14-1-2-14)23-13-24-19/h3-6,11-14,22H,1-2,7-10H2,(H,25,28)(H,26,30)(H,23,24,27) SEAAQBDCEFFTFY-UHFFFAOYSA-N 50629592 CHEMBL5415967 Cyclin-dependent kinase 6 Homo sapiens 125 ChEMBL 10.1016/j.ejmech.2023.115448 10.7270/Q2M3316G 37163951 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629592&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0 51565806 O=C(Nc1ccc(cc1)N1CCNCC1)c1n[nH]cc1Nc1cc(OC2CCCC2)ncn1 InChI=1S/C23H28N8O2/c32-23(28-16-5-7-17(8-6-16)31-11-9-24-10-12-31)22-19(14-27-30-22)29-20-13-21(26-15-25-20)33-18-3-1-2-4-18/h5-8,13-15,18,24H,1-4,9-12H2,(H,27,30)(H,28,32)(H,25,26,29) YXJHRAJQRBFYSF-UHFFFAOYSA-N 50629597 CHEMBL5435746 Cyclin-dependent kinase 6 Homo sapiens 158 ChEMBL 10.1016/j.ejmech.2023.115448 10.7270/Q2M3316G 37163951 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=909&target=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629597&enzyme=Cyclin-dependent+kinase+6&column=ki&startPg=0&Increment=50&submit=Search 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA 4TTH,1G3N,1BLX,1BI8,1BI7,2F2C,2EUF,1XO2,1JOW,8I0M,5L2T,5L2S,5L2I,4EZ5,4AUA,3NUX,3NUP,6OQO,6OQL Cyclin-dependent kinase 6 CDK6_HUMAN Q00534 A4D1G0