BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 387153 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C26H18Cl3N3O2/c1-32-15-30-14-22(32)26(33,16-7-10-18(27)11-8-16)17-9-12-21-20(13-17)23(28)24(25(29)31-21)34-19-5-3-2-4-6-19/h2-15,33H,1H3 AAFZIZYKCOZVIE-UHFFFAOYSA-N 221227 US9303015, 1 Nuclear receptor ROR-gamma [258-518] 110 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221227&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223686 335960302 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387154 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl2N3O3/c1-3-35-27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(34,24-16-31-17-33(24)2)18-9-12-20(29)13-10-18/h4-17,34H,3H2,1-2H3 UYBIBQBVLKWEAI-UHFFFAOYSA-N 221228 US9303015, 2a::US9303015, 2b::US9303015, 2c Nuclear receptor ROR-gamma [258-518] 84 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223688 335960303 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387155 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl2N3O3/c1-3-35-27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(34,24-16-31-17-33(24)2)18-9-12-20(29)13-10-18/h4-17,34H,3H2,1-2H3 UYBIBQBVLKWEAI-UHFFFAOYSA-N 221228 US9303015, 2a::US9303015, 2b::US9303015, 2c Nuclear receptor ROR-gamma [258-518] 480 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223688 335960303 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387156 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl2N3O3/c1-3-35-27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(34,24-16-31-17-33(24)2)18-9-12-20(29)13-10-18/h4-17,34H,3H2,1-2H3 UYBIBQBVLKWEAI-UHFFFAOYSA-N 221228 US9303015, 2a::US9303015, 2b::US9303015, 2c Nuclear receptor ROR-gamma [258-518] 41 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223688 335960303 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387157 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O2/c1-4-36(5-2)29-28(38-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)34-29)30(37,26-18-33-19-35(26)3)20-11-14-22(31)15-12-20/h6-19,37H,4-5H2,1-3H3 QSNQBKVAYOUNKI-UHFFFAOYSA-N 221229 US9303015, 3a::US9303015, 3b::US9303015, 3c Nuclear receptor ROR-gamma [258-518] 59 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223742 335960304 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387158 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O2/c1-4-36(5-2)29-28(38-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)34-29)30(37,26-18-33-19-35(26)3)20-11-14-22(31)15-12-20/h6-19,37H,4-5H2,1-3H3 QSNQBKVAYOUNKI-UHFFFAOYSA-N 221229 US9303015, 3a::US9303015, 3b::US9303015, 3c Nuclear receptor ROR-gamma [258-518] 320 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223742 335960304 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387159 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O2/c1-4-36(5-2)29-28(38-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)34-29)30(37,26-18-33-19-35(26)3)20-11-14-22(31)15-12-20/h6-19,37H,4-5H2,1-3H3 QSNQBKVAYOUNKI-UHFFFAOYSA-N 221229 US9303015, 3a::US9303015, 3b::US9303015, 3c Nuclear receptor ROR-gamma [258-518] 17 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223742 335960304 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387160 COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(Cl)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C26H20Cl2N4O3/c1-32-15-29-14-21(32)26(33,17-9-11-22(34-2)30-13-17)16-8-10-20-19(12-16)23(27)24(25(28)31-20)35-18-6-4-3-5-7-18/h3-15,33H,1-2H3 IHOMEIUZNUWVSU-UHFFFAOYSA-N 221230 US9303015, 4 Nuclear receptor ROR-gamma [258-518] 14 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221230&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223744 335960305 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387161 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C30H30ClN5O3/c1-5-36(6-2)29-28(39-22-10-8-7-9-11-22)27(31)23-16-20(12-14-24(23)34-29)30(37,25-18-32-19-35(25)3)21-13-15-26(38-4)33-17-21/h7-19,37H,5-6H2,1-4H3 OBAXSFJDXZIJNI-UHFFFAOYSA-N 221231 US9303015, 5a::US9303015, 5b::US9303015, 5c Nuclear receptor ROR-gamma [258-518] 12 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223687 335960306 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387162 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C30H30ClN5O3/c1-5-36(6-2)29-28(39-22-10-8-7-9-11-22)27(31)23-16-20(12-14-24(23)34-29)30(37,25-18-32-19-35(25)3)21-13-15-26(38-4)33-17-21/h7-19,37H,5-6H2,1-4H3 OBAXSFJDXZIJNI-UHFFFAOYSA-N 221231 US9303015, 5a::US9303015, 5b::US9303015, 5c Nuclear receptor ROR-gamma [258-518] 12 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223687 335960306 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387163 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C30H30ClN5O3/c1-5-36(6-2)29-28(39-22-10-8-7-9-11-22)27(31)23-16-20(12-14-24(23)34-29)30(37,25-18-32-19-35(25)3)21-13-15-26(38-4)33-17-21/h7-19,37H,5-6H2,1-4H3 OBAXSFJDXZIJNI-UHFFFAOYSA-N 221231 US9303015, 5a::US9303015, 5b::US9303015, 5c Nuclear receptor ROR-gamma [258-518] 26 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223687 335960306 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387164 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O2/c1-4-39(5-2)28-27(41-21-9-7-6-8-10-21)26(31)22-15-19(11-13-23(22)37-28)29(40,25-17-35-18-38(25)3)20-12-14-24(36-16-20)30(32,33)34/h6-18,40H,4-5H2,1-3H3 LFUGPNMUNFREIQ-UHFFFAOYSA-N 221232 US9303015, 6a::US9303015, 6b::US9303015, 6c Nuclear receptor ROR-gamma [258-518] 51 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223741 335960307 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387165 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O2/c1-4-39(5-2)28-27(41-21-9-7-6-8-10-21)26(31)22-15-19(11-13-23(22)37-28)29(40,25-17-35-18-38(25)3)20-12-14-24(36-16-20)30(32,33)34/h6-18,40H,4-5H2,1-3H3 LFUGPNMUNFREIQ-UHFFFAOYSA-N 221232 US9303015, 6a::US9303015, 6b::US9303015, 6c Nuclear receptor ROR-gamma [258-518] 8.3 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223741 335960307 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387166 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O2/c1-4-39(5-2)28-27(41-21-9-7-6-8-10-21)26(31)22-15-19(11-13-23(22)37-28)29(40,25-17-35-18-38(25)3)20-12-14-24(36-16-20)30(32,33)34/h6-18,40H,4-5H2,1-3H3 LFUGPNMUNFREIQ-UHFFFAOYSA-N 221232 US9303015, 6a::US9303015, 6b::US9303015, 6c Nuclear receptor ROR-gamma [258-518] 170 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223741 335960307 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387167 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C31H27Cl2N3O2/c1-3-36(4-2)30-29(38-25-13-6-5-7-14-25)28(33)26-19-22(15-16-27(26)35-30)31(37,23-11-9-17-34-20-23)21-10-8-12-24(32)18-21/h5-20,37H,3-4H2,1-2H3 QFGGXRYCVZZIMH-UHFFFAOYSA-N 221233 US9303015, 7 Nuclear receptor ROR-gamma [258-518] 34 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221233&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223743 335960308 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387168 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncs1)c1cncn1C InChI=1S/C27H26ClN5O2S/c1-4-33(5-2)26-25(35-19-9-7-6-8-10-19)24(28)20-13-18(11-12-21(20)31-26)27(34,23-15-30-17-36-23)22-14-29-16-32(22)3/h6-17,34H,4-5H2,1-3H3 VAUSKCYWXYGVQL-UHFFFAOYSA-N 221234 US9303015, 8 Nuclear receptor ROR-gamma [258-518] 7.2 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221234&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223745 335960309 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387169 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H26ClF4N5O2/c1-4-40(5-2)28-27(42-21-10-8-20(32)9-11-21)26(31)22-14-18(6-12-23(22)38-28)29(41,25-16-36-17-39(25)3)19-7-13-24(37-15-19)30(33,34)35/h6-17,41H,4-5H2,1-3H3 AXVBVFNCJWQPMU-UHFFFAOYSA-N 221235 US9303015, 9a::US9303015, 9b::US9303015, 9c Nuclear receptor ROR-gamma [258-518] 33 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221235&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223794 335960310 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387170 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H26ClF4N5O2/c1-4-40(5-2)28-27(42-21-10-8-20(32)9-11-21)26(31)22-14-18(6-12-23(22)38-28)29(41,25-16-36-17-39(25)3)19-7-13-24(37-15-19)30(33,34)35/h6-17,41H,4-5H2,1-3H3 AXVBVFNCJWQPMU-UHFFFAOYSA-N 221235 US9303015, 9a::US9303015, 9b::US9303015, 9c Nuclear receptor ROR-gamma [258-518] 81 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221235&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223794 335960310 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387171 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H26ClF4N5O2/c1-4-40(5-2)28-27(42-21-10-8-20(32)9-11-21)26(31)22-14-18(6-12-23(22)38-28)29(41,25-16-36-17-39(25)3)19-7-13-24(37-15-19)30(33,34)35/h6-17,41H,4-5H2,1-3H3 AXVBVFNCJWQPMU-UHFFFAOYSA-N 221235 US9303015, 9a::US9303015, 9b::US9303015, 9c Nuclear receptor ROR-gamma [258-518] 8 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221235&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223794 335960310 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387172 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C28H25ClN4O4/c1-4-36-27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(34,23-16-30-17-33(23)2)19-11-13-24(35-3)31-15-19/h5-17,34H,4H2,1-3H3 RCZIUKXBTCTDBV-UHFFFAOYSA-N 221236 US9303015, 10a::US9303015, 10b::US9303015, 10c Nuclear receptor ROR-gamma [258-518] 8.5 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221236&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223796 335960311 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387173 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C28H25ClN4O4/c1-4-36-27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(34,23-16-30-17-33(23)2)19-11-13-24(35-3)31-15-19/h5-17,34H,4H2,1-3H3 RCZIUKXBTCTDBV-UHFFFAOYSA-N 221236 US9303015, 10a::US9303015, 10b::US9303015, 10c Nuclear receptor ROR-gamma [258-518] 3.4 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221236&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223796 335960311 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387174 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C28H25ClN4O4/c1-4-36-27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(34,23-16-30-17-33(23)2)19-11-13-24(35-3)31-15-19/h5-17,34H,4H2,1-3H3 RCZIUKXBTCTDBV-UHFFFAOYSA-N 221236 US9303015, 10a::US9303015, 10b::US9303015, 10c Nuclear receptor ROR-gamma [258-518] 39 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221236&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223796 335960311 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387175 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518] 22 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387176 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518] 34 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387177 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518] 10 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387178 COc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(31-22)34-2)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 DMNDKESGHYMQPJ-UHFFFAOYSA-N 221241 US9303015, 15a::US9303015, 15b::US9303015, 15c Nuclear receptor ROR-gamma [258-518] 150 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221241&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223795 335960313 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387179 COc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(31-22)34-2)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 DMNDKESGHYMQPJ-UHFFFAOYSA-N 221241 US9303015, 15a::US9303015, 15b::US9303015, 15c Nuclear receptor ROR-gamma [258-518] 300 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221241&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223795 335960313 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387180 COc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(31-22)34-2)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 DMNDKESGHYMQPJ-UHFFFAOYSA-N 221241 US9303015, 15a::US9303015, 15b::US9303015, 15c Nuclear receptor ROR-gamma [258-518] 33 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221241&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223795 335960313 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387181 CN(C)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2N4O2/c1-33(2)27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(35,24-16-31-17-34(24)3)18-9-12-20(29)13-10-18/h4-17,35H,1-3H3 AUNRETUDSHCGLM-UHFFFAOYSA-N 221242 US9303015, 16 Nuclear receptor ROR-gamma [258-518] 31 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221242&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223797 335960314 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387182 COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(N(C)C)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C28H26ClN5O3/c1-33(2)27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(35,23-16-30-17-34(23)3)19-11-13-24(36-4)31-15-19/h5-17,35H,1-4H3 TZZKHOLXWCJBLK-UHFFFAOYSA-N 221243 US9303015, 17 Nuclear receptor ROR-gamma [258-518] 4.1 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221243&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223842 335960315 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387183 COc1c(Oc2ccccc2)c(Cl)nc2ccc(cc12)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(34-2)25(26(29)31-22)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 SWUYOUYKNRCXJY-UHFFFAOYSA-N 221244 US9303015, 18 Nuclear receptor ROR-gamma [258-518] 1700 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221244&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223844 335960316 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387184 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C27H18Cl2N4O2/c1-33-16-31-15-24(33)27(34,17-7-10-19(28)11-8-17)18-9-12-22-21(13-18)25(29)26(23(14-30)32-22)35-20-5-3-2-4-6-20/h2-13,15-16,34H,1H3 JYJUFLUFYWUNRJ-UHFFFAOYSA-N 221245 US9303015, 19 Nuclear receptor ROR-gamma [258-518] 32 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221245&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223846 335960317 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387185 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 InChI=1S/C28H18ClN5O2/c1-34-17-32-16-26(34)28(35,18-7-10-20(29)11-8-18)19-9-12-24-22(13-19)23(14-30)27(25(15-31)33-24)36-21-5-3-2-4-6-21/h2-13,16-17,35H,1H3 ZIWGQMCFFKYIPD-UHFFFAOYSA-N 221246 US9303015, 20 Nuclear receptor ROR-gamma [258-518] 5.7 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221246&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223890 335960318 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387186 OC(c1cnc[nH]1)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 221289 US9303015, 22b::US9303015, 22c Nuclear receptor ROR-gamma [258-518] 2.9 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221289&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 126842401 335960345 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387187 OC(c1cnc[nH]1)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 221289 US9303015, 22b::US9303015, 22c Nuclear receptor ROR-gamma [258-518] 97 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221289&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 126842401 335960345 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387188 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccc(F)cc3)c(Cl)c2c1 InChI=1S/C27H17Cl2FN4O2/c1-34-15-32-14-24(34)27(35,16-2-5-18(28)6-3-16)17-4-11-22-21(12-17)25(29)26(23(13-31)33-22)36-20-9-7-19(30)8-10-20/h2-12,14-15,35H,1H3 FEMFLJUOZBWZNG-UHFFFAOYSA-N 221249 US9303015, 23 Nuclear receptor ROR-gamma [258-518] 26 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221249&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223892 335960321 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387189 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccc(Cl)cc3)c(c2c1)C(F)(F)F InChI=1S/C28H16ClF6N5O2/c1-40-14-37-13-23(40)26(41,16-3-9-22(38-12-16)27(30,31)32)15-2-8-20-19(10-15)24(28(33,34)35)25(21(11-36)39-20)42-18-6-4-17(29)5-7-18/h2-10,12-14,41H,1H3 PMJXQSOZVOJFLZ-UHFFFAOYSA-N 221250 US9303015, 24 Nuclear receptor ROR-gamma [258-518] 4.2 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221250&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223945 335960322 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387190 CCOc1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF6N4O3/c1-3-42-26-25(43-19-8-6-18(30)7-9-19)24(29(34,35)36)20-12-16(4-10-21(20)39-26)27(41,23-14-37-15-40(23)2)17-5-11-22(38-13-17)28(31,32)33/h4-15,41H,3H2,1-2H3 DJTRYZOLOWBFQI-UHFFFAOYSA-N 221251 US9303015, 25a::US9303015, 25b::US9303015, 25c Nuclear receptor ROR-gamma [258-518] 61 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221251&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223947 335960323 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387191 CCOc1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF6N4O3/c1-3-42-26-25(43-19-8-6-18(30)7-9-19)24(29(34,35)36)20-12-16(4-10-21(20)39-26)27(41,23-14-37-15-40(23)2)17-5-11-22(38-13-17)28(31,32)33/h4-15,41H,3H2,1-2H3 DJTRYZOLOWBFQI-UHFFFAOYSA-N 221251 US9303015, 25a::US9303015, 25b::US9303015, 25c Nuclear receptor ROR-gamma [258-518] 80 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221251&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223947 335960323 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387192 CCOc1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF6N4O3/c1-3-42-26-25(43-19-8-6-18(30)7-9-19)24(29(34,35)36)20-12-16(4-10-21(20)39-26)27(41,23-14-37-15-40(23)2)17-5-11-22(38-13-17)28(31,32)33/h4-15,41H,3H2,1-2H3 DJTRYZOLOWBFQI-UHFFFAOYSA-N 221251 US9303015, 25a::US9303015, 25b::US9303015, 25c Nuclear receptor ROR-gamma [258-518] 20 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221251&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223947 335960323 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387193 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C31H27Cl2F3N4O2/c1-4-40(5-2)29-28(42-23-13-11-22(33)12-14-23)27(31(34,35)36)24-16-20(8-15-25(24)38-29)30(41,26-17-37-18-39(26)3)19-6-9-21(32)10-7-19/h6-18,41H,4-5H2,1-3H3 OBMBDUORCAESAA-UHFFFAOYSA-N 221252 US9303015, 26 Nuclear receptor ROR-gamma [258-518] 100 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221252&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223948 335960324 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387194 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C31H26ClF6N5O2/c1-4-43(5-2)28-27(45-21-10-8-20(32)9-11-21)26(31(36,37)38)22-14-18(6-12-23(22)41-28)29(44,25-16-39-17-42(25)3)19-7-13-24(40-15-19)30(33,34)35/h6-17,44H,4-5H2,1-3H3 LTFNIYSAZCKYLQ-UHFFFAOYSA-N 221253 US9303015, 27a::US9303015, 27b::US9303015, 27c Nuclear receptor ROR-gamma [258-518] 75 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221253&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 73442853 335960325 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387195 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C31H26ClF6N5O2/c1-4-43(5-2)28-27(45-21-10-8-20(32)9-11-21)26(31(36,37)38)22-14-18(6-12-23(22)41-28)29(44,25-16-39-17-42(25)3)19-7-13-24(40-15-19)30(33,34)35/h6-17,44H,4-5H2,1-3H3 LTFNIYSAZCKYLQ-UHFFFAOYSA-N 221253 US9303015, 27a::US9303015, 27b::US9303015, 27c Nuclear receptor ROR-gamma [258-518] 14 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221253&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 73442853 335960325 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387196 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C31H26ClF6N5O2/c1-4-43(5-2)28-27(45-21-10-8-20(32)9-11-21)26(31(36,37)38)22-14-18(6-12-23(22)41-28)29(44,25-16-39-17-42(25)3)19-7-13-24(40-15-19)30(33,34)35/h6-17,44H,4-5H2,1-3H3 LTFNIYSAZCKYLQ-UHFFFAOYSA-N 221253 US9303015, 27a::US9303015, 27b::US9303015, 27c Nuclear receptor ROR-gamma [258-518] 1400 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221253&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 73442853 335960325 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387197 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C31H29ClF3N5O3/c1-5-40(6-2)29-28(43-22-11-9-21(32)10-12-22)27(31(33,34)35)23-15-19(7-13-24(23)38-29)30(41,25-17-36-18-39(25)3)20-8-14-26(42-4)37-16-20/h7-18,41H,5-6H2,1-4H3 FZNXQPHQEMTZMH-UHFFFAOYSA-N 221254 US9303015, 28 Nuclear receptor ROR-gamma [258-518] 72 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221254&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223019 335960326 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387198 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccccc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C31H28ClF3N4O2/c1-4-39(5-2)29-28(41-23-9-7-6-8-10-23)27(31(33,34)35)24-17-21(13-16-25(24)37-29)30(40,26-18-36-19-38(26)3)20-11-14-22(32)15-12-20/h6-19,40H,4-5H2,1-3H3 ZDNAKVBXOLTMMW-UHFFFAOYSA-N 221255 US9303015, 29 Nuclear receptor ROR-gamma [258-518] 170 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221255&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223893 335960327 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387199 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(Cl)cc3)c(Cl)c2c1 InChI=1S/C29H22Cl2F3N5O2/c1-38-16-35-15-24(38)28(40,18-4-10-23(36-14-18)29(32,33)34)17-3-9-22-21(13-17)25(31)26(27(37-22)39-11-2-12-39)41-20-7-5-19(30)6-8-20/h3-10,13-16,40H,2,11-12H2,1H3 MDPNKAIDFYRNEN-UHFFFAOYSA-N 221256 US9303015, 30a::US9303015, 30b::US9303015, 30c Nuclear receptor ROR-gamma [258-518] 1.8 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221256&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 86715463 335960328 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387200 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(Cl)cc3)c(Cl)c2c1 InChI=1S/C29H22Cl2F3N5O2/c1-38-16-35-15-24(38)28(40,18-4-10-23(36-14-18)29(32,33)34)17-3-9-22-21(13-17)25(31)26(27(37-22)39-11-2-12-39)41-20-7-5-19(30)6-8-20/h3-10,13-16,40H,2,11-12H2,1H3 MDPNKAIDFYRNEN-UHFFFAOYSA-N 221256 US9303015, 30a::US9303015, 30b::US9303015, 30c Nuclear receptor ROR-gamma [258-518] 8.9 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221256&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 86715463 335960328 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387201 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(Cl)cc3)c(Cl)c2c1 InChI=1S/C29H22Cl2F3N5O2/c1-38-16-35-15-24(38)28(40,18-4-10-23(36-14-18)29(32,33)34)17-3-9-22-21(13-17)25(31)26(27(37-22)39-11-2-12-39)41-20-7-5-19(30)6-8-20/h3-10,13-16,40H,2,11-12H2,1H3 MDPNKAIDFYRNEN-UHFFFAOYSA-N 221256 US9303015, 30a::US9303015, 30b::US9303015, 30c Nuclear receptor ROR-gamma [258-518] 0.53 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221256&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 86715463 335960328 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387202 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H22ClF3N6O2/c1-39-17-36-16-25(39)29(41,20-6-10-24(37-15-20)30(32,33)34)19-5-9-23-22(13-19)26(31)27(28(38-23)40-11-2-12-40)42-21-7-3-18(14-35)4-8-21/h3-10,13,15-17,41H,2,11-12H2,1H3 HGMJOSNOVDDGAZ-UHFFFAOYSA-N 221257 US9303015, 31a::US9303015, 31b::US9303015, 31c Nuclear receptor ROR-gamma [258-518] 3.6 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221257&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223946 335960329 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387203 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H22ClF3N6O2/c1-39-17-36-16-25(39)29(41,20-6-10-24(37-15-20)30(32,33)34)19-5-9-23-22(13-19)26(31)27(28(38-23)40-11-2-12-40)42-21-7-3-18(14-35)4-8-21/h3-10,13,15-17,41H,2,11-12H2,1H3 HGMJOSNOVDDGAZ-UHFFFAOYSA-N 221257 US9303015, 31a::US9303015, 31b::US9303015, 31c Nuclear receptor ROR-gamma [258-518] 14 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221257&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223946 335960329 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387204 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H22ClF3N6O2/c1-39-17-36-16-25(39)29(41,20-6-10-24(37-15-20)30(32,33)34)19-5-9-23-22(13-19)26(31)27(28(38-23)40-11-2-12-40)42-21-7-3-18(14-35)4-8-21/h3-10,13,15-17,41H,2,11-12H2,1H3 HGMJOSNOVDDGAZ-UHFFFAOYSA-N 221257 US9303015, 31a::US9303015, 31b::US9303015, 31c Nuclear receptor ROR-gamma [258-518] 0.72 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221257&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223946 335960329 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387205 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H23Cl2N5O2/c1-36-18-34-17-26(36)30(38,20-5-8-22(31)9-6-20)21-7-12-25-24(15-21)27(32)28(29(35-25)37-13-2-14-37)39-23-10-3-19(16-33)4-11-23/h3-12,15,17-18,38H,2,13-14H2,1H3 CBOYVDJPUOJMBW-UHFFFAOYSA-N 221258 US9303015, 32a::US9303015, 32b::US9303015, 32c Nuclear receptor ROR-gamma [258-518] 6.9 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221258&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223017 335960330 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387206 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H23Cl2N5O2/c1-36-18-34-17-26(36)30(38,20-5-8-22(31)9-6-20)21-7-12-25-24(15-21)27(32)28(29(35-25)37-13-2-14-37)39-23-10-3-19(16-33)4-11-23/h3-12,15,17-18,38H,2,13-14H2,1H3 CBOYVDJPUOJMBW-UHFFFAOYSA-N 221258 US9303015, 32a::US9303015, 32b::US9303015, 32c Nuclear receptor ROR-gamma [258-518] 32 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221258&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223017 335960330 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387207 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H23Cl2N5O2/c1-36-18-34-17-26(36)30(38,20-5-8-22(31)9-6-20)21-7-12-25-24(15-21)27(32)28(29(35-25)37-13-2-14-37)39-23-10-3-19(16-33)4-11-23/h3-12,15,17-18,38H,2,13-14H2,1H3 CBOYVDJPUOJMBW-UHFFFAOYSA-N 221258 US9303015, 32a::US9303015, 32b::US9303015, 32c Nuclear receptor ROR-gamma [258-518] 3.3 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221258&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223017 335960330 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387208 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C31H24ClF3N6O2/c1-40-18-37-17-26(40)30(42,21-7-11-25(38-16-21)31(33,34)35)20-6-10-24-23(14-20)27(32)28(29(39-24)41-12-2-3-13-41)43-22-8-4-19(15-36)5-9-22/h4-11,14,16-18,42H,2-3,12-13H2,1H3 XTJBVBCWFGLULK-UHFFFAOYSA-N 221259 US9303015, 33 Nuclear receptor ROR-gamma [258-518] 66 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221259&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223018 335960331 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387209 COCCN(C)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O3/c1-38(13-14-41-3)28-27(42-21-7-5-4-6-8-21)26(31)22-15-19(9-11-23(22)37-28)29(40,25-17-35-18-39(25)2)20-10-12-24(36-16-20)30(32,33)34/h4-12,15-18,40H,13-14H2,1-3H3 VNLMKCKJADGMDH-UHFFFAOYSA-N 221260 US9303015, 34 Nuclear receptor ROR-gamma [258-518] 18 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221260&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223020 335960332 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387210 CN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C28H20Cl3N3O/c1-34(22-10-3-2-4-11-22)26-25(30)23-16-19(12-13-24(23)33-27(26)31)28(35,20-8-6-14-32-17-20)18-7-5-9-21(29)15-18/h2-17,35H,1H3 CXISRSBZHJUAJP-UHFFFAOYSA-N 221261 US9303015, 35 Nuclear receptor ROR-gamma [258-518] 23 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221261&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223021 335960333 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387211 CCOc1nc2ccc(cc2c(Cl)c1N(C)c1ccccc1)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C30H25Cl2N3O2/c1-3-37-29-28(35(2)24-12-5-4-6-13-24)27(32)25-18-21(14-15-26(25)34-29)30(36,22-10-8-16-33-19-22)20-9-7-11-23(31)17-20/h4-19,36H,3H2,1-2H3 CZNDPOIIONPSFG-UHFFFAOYSA-N 221262 US9303015, 36 Nuclear receptor ROR-gamma [258-518] 32 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221262&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223087 335960334 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387212 CCOc1nc2ccc(cc2c(OCC)c1N(C)c1ccccc1)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C32H30ClN3O3/c1-4-38-30-27-20-23(32(37,24-12-10-18-34-21-24)22-11-9-13-25(33)19-22)16-17-28(27)35-31(39-5-2)29(30)36(3)26-14-7-6-8-15-26/h6-21,37H,4-5H2,1-3H3 KFLLJWKYKAXTGP-UHFFFAOYSA-N 221263 US9303015, 37 Nuclear receptor ROR-gamma [258-518] 5700 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221263&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223089 335960335 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387213 CN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl3N4O/c1-33-16-31-15-23(33)27(35,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(30)32-22)34(2)20-6-4-3-5-7-20/h3-16,35H,1-2H3 WPVZONCHBLXUMN-UHFFFAOYSA-N 221264 US9303015, 38 Nuclear receptor ROR-gamma [258-518] 35 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221264&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223091 335960336 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387214 CCN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C29H22Cl3N3O/c1-2-35(23-11-4-3-5-12-23)27-26(31)24-17-20(13-14-25(24)34-28(27)32)29(36,21-9-7-15-33-18-21)19-8-6-10-22(30)16-19/h3-18,36H,2H2,1H3 MDEOYKJUOUYVQF-UHFFFAOYSA-N 221265 US9303015, 39 Nuclear receptor ROR-gamma [258-518] 820 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221265&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223160 335960337 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387215 CCN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl3N4O/c1-3-35(21-7-5-4-6-8-21)26-25(30)22-15-19(11-14-23(22)33-27(26)31)28(36,24-16-32-17-34(24)2)18-9-12-20(29)13-10-18/h4-17,36H,3H2,1-2H3 QKBAPBUOFNHEOM-UHFFFAOYSA-N 221266 US9303015, 40 Nuclear receptor ROR-gamma [258-518] 790 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221266&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223162 335960338 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387216 CC(C)N(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C29H25Cl3N4O/c1-18(2)36(22-7-5-4-6-8-22)27-26(31)23-15-20(11-14-24(23)34-28(27)32)29(37,25-16-33-17-35(25)3)19-9-12-21(30)13-10-19/h4-18,37H,1-3H3 UAQRZTVJCIBCKB-UHFFFAOYSA-N 221267 US9303015, 41 Nuclear receptor ROR-gamma [258-518] 430 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221267&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223163 335960339 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387217 OC(c1cccnc1)(c1cccc(Cl)c1)c1ccc2nc(Cl)c(Nc3ccccc3)c(Cl)c2c1 InChI=1S/C27H18Cl3N3O/c28-20-8-4-6-17(14-20)27(34,19-7-5-13-31-16-19)18-11-12-23-22(15-18)24(29)25(26(30)33-23)32-21-9-2-1-3-10-21/h1-16,32,34H FVDNUOYVMNZOQL-UHFFFAOYSA-N 221268 US9303015, 42 Nuclear receptor ROR-gamma [258-518] 37 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221268&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 117883602 335960340 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387218 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Nc3ccccc3)c(Cl)c2c1 InChI=1S/C26H19Cl3N4O/c1-33-15-30-14-22(33)26(34,16-7-10-18(27)11-8-16)17-9-12-21-20(13-17)23(28)24(25(29)32-21)31-19-5-3-2-4-6-19/h2-15,31,34H,1H3 PBBLAYPQLHWIDA-UHFFFAOYSA-N 221269 US9303015, 43 Nuclear receptor ROR-gamma [258-518] 110 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221269&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223088 335960341 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387219 CCN(CC)c1nc2ccc(cc2c(Cl)c1N(C(=O)OC(C)(C)C)c1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C35H37Cl2N5O3/c1-7-41(8-2)32-31(42(26-12-10-9-11-13-26)33(43)45-34(3,4)5)30(37)27-20-24(16-19-28(27)39-32)35(44,29-21-38-22-40(29)6)23-14-17-25(36)18-15-23/h9-22,44H,7-8H2,1-6H3 PBIQIMKSLWQFDB-UHFFFAOYSA-N 221270 US9303015, 44 Nuclear receptor ROR-gamma [258-518] 710 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221270&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223090 335960342 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387220 CCN(CC)c1nc2ccc(cc2c(Cl)c1Nc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H29Cl2N5O/c1-4-37(5-2)29-28(34-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)35-29)30(38,26-18-33-19-36(26)3)20-11-14-22(31)15-12-20/h6-19,34,38H,4-5H2,1-3H3 SRJGTOCTWCHXDX-UHFFFAOYSA-N 221271 US9303015, 45 Nuclear receptor ROR-gamma [258-518] 270 7 1.00 C US Patent 10.7270/Q29P30H5 aid1802552 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9293&target=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221271&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%5D&column=ki&startPg=0&Increment=50&submit=Search 74223159 335960343 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 3B0W,3KYT,3L0J,3L0L,4S14,4WPF,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5AYG,5EJV,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5LWP,5NI5,5NI7,5NI8,5NIB,5UFO,5UFR,5UHI,5W4R,5X8S,5X8U,5YP5,5YP6,5ZA1,6B30,6B31,6B33,6BN6,6BR2,6BR3,6CN5,6CVH,6E3E,6E3G,6ESN,6FGQ,6J1L,6J3N,6NAD,6NWT,6O98,6Q2W,6R7A,6R7J,6R7K,6SAL,6SLZ,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6VSW,6XFV,7E3M,7JH2,7KCO,7NEC,7NP5,7NP6,7OFI,7OFK,7QP4,7W3P,7W3Q,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8