Compile Data Set for Download or QSAR
Report error Found 127 of ic50 for UniProtKB: P32297
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329477BDBM50329477((S)-N-(3-(4-(3-aminopropylamino)butylamino)propyl)...)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515186BDBM50515186(CHEMBL4462550)
Affinity DataIC50: 0.350nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515196BDBM50515196(CHEMBL4454232)
Affinity DataIC50: 0.370nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515192BDBM50515192(CHEMBL4556075)
Affinity DataIC50: 0.460nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515195BDBM50515195(CHEMBL4443845)
Affinity DataIC50: 0.550nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515185BDBM50515185(CHEMBL4585225)
Affinity DataIC50: 0.570nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515189BDBM50515189(CHEMBL4463134)
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515188BDBM50515188(CHEMBL4531333)
Affinity DataIC50: 0.920nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515187BDBM50515187(CHEMBL425006)
Affinity DataIC50: 0.930nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515190BDBM50515190(CHEMBL4440025)
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515194BDBM50515194(CHEMBL4559471)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515193BDBM50515193(CHEMBL4518954)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50515191BDBM50515191(CHEMBL371789)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329475BDBM50329475((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001695BDBM50001695(CHEMBL3238085)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-evoked current by voltag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329474BDBM50329474((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329473BDBM50329473((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329476BDBM50329476((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50094298BDBM50094298(N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propy...)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597657BDBM50597657(CHEMBL5174461)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human alpha3beta4 nAChR in SH-SY5Y cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490639BDBM50490639(CHEMBL2332278)
Affinity DataIC50: 80nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001697BDBM50001697(CHEMBL3238027)
Affinity DataIC50: 97nMAssay Description:Antagonist activity at alpha3beta4 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50445327BDBM50445327(CHEMBL3104240)
Affinity DataIC50: 97nMAssay Description:Inhibition of alpha3beta4 nAChR (unknown origin) expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50369323BDBM50369323(MECAMYLAMINE)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50441363BDBM50441363(CHEMBL2332280)
Affinity DataIC50: 100nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50567433BDBM50567433(CHEMBL4869892)
Affinity DataIC50: 179nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-ele...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490640BDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataIC50: 200nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597656BDBM50597656(CHEMBL5209526)
Affinity DataIC50: 347nMAssay Description:Antagonist activity at human alpha3beta4 nAChR in SH-SY5Y cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50441363BDBM50441363(CHEMBL2332280)
Affinity DataIC50: 380nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50441363BDBM50441363(CHEMBL2332280)
Affinity DataIC50: 380nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490640BDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataIC50: 398nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490640BDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataIC50: 400nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50508934BDBM50508934(CHEMBL4463817)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human AChR alpha3beta4 transfected in human HEK293 cells assessed as decrease in epibatidine-induced calcium influx incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587088BDBM50587088(CHEMBL5082749)
Affinity DataIC50: 501nMAssay Description:Antagonist activity at human alpha3beta4 nAChR in SH-SY5Y cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50445325BDBM50445325(CHEMBL3104238)
Affinity DataIC50: 518nMAssay Description:Antagonist activity at human alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490639BDBM50490639(CHEMBL2332278)
Affinity DataIC50: 600nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490639BDBM50490639(CHEMBL2332278)
Affinity DataIC50: 603nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50445323BDBM50445323(CHEMBL3104236)
Affinity DataIC50: 755nMAssay Description:Antagonist activity at human alpha3beta4 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electrophy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001727BDBM50001727(CHEMBL3238025)
Affinity DataIC50: 755nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in Xenopus laevis oocytes by two-electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341207BDBM50341207((S,S)-2-(3'-Chlorophenyl)-4-ethyl-3,5,5-trimethylm...)
Affinity DataIC50: 790nMAssay Description:Antagonist activity at human alpha3beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339933BDBM50339933(1,1',1'',1'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...)
Affinity DataIC50: 800nMAssay Description:Inhibition of alpha3beta4 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50508933BDBM50508933(CHEMBL4461511)
Affinity DataIC50: 960nMAssay Description:Antagonist activity at human AChR alpha3beta4 transfected in human HEK293 cells assessed as decrease in epibatidine-induced calcium influx incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341208BDBM50341208((S,S)-2-(3'-Chlorophenyl)-3,5,5-trimethyl-4-propyl...)
Affinity DataIC50: 980nMAssay Description:Antagonist activity at human alpha3beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451971BDBM50451971(CHEMBL330867)
Affinity DataIC50: 1.20E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149051BDBM50149051(2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoic ac...)
Affinity DataIC50: 1.30E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451974BDBM50451974(CHEMBL340342)
Affinity DataIC50: 1.30E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322520BDBM50322520((2S,3S)-2-Biphenyl-4-yl-3,5,5-trimethylmorpholin-2...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451972BDBM50451972(CHEMBL125960)
Affinity DataIC50: 1.30E+3nMAssay Description:Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597655BDBM50597655(CHEMBL5185118)
Affinity DataIC50: 1.35E+3nMAssay Description:Antagonist activity at human alpha3beta4 nAChR in SH-SY5Y cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322528BDBM50322528((2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human alpha3beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion effluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
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