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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408477(CHEMBL5275820)
Affinity DataKd:  0.260nMAssay Description:Binding affinity to human PDE4 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataKd: <0.630nMAssay Description:Binding affinity to Full-length human PRMT5/human MEP50 assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to METTL3/METTL14 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50042058((4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrroli...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to human PDE4 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataKd: <4nMAssay Description:Binding affinity to Full-length human PRMT5/human MEP50 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to human STAT5A/STAT5B incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293150(N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...)
Affinity DataKd:  4.5nMAssay Description:Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM20899(CHEMBL252124 | 5-(5-chloro-2,4-dihydroxyphenyl)-N-...)
Affinity DataKd:  4.5nMAssay Description:Binding affinity to HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataKd: <5nMAssay Description:Displacement of kinase tracer 236 from CDK9/Cyclin T1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50323460(N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthoh...)
Affinity DataKd:  5.80nMAssay Description:Binding affinity to human GST-tagged MUS81-ECE1 expressed in Escherichia coli BL21(DE3)Rosetta2 cells assessed as dissociation constant by Surface pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50618708(CHEMBL4071130)
Affinity DataKd:  6.10nMAssay Description:Binding affinity to human GST-tagged MUS81-ECE1 expressed in Escherichia coli BL21(DE3)Rosetta2 cells assessed as dissociation constant by Surface pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataKd:  11nMAssay Description:Binding affinity to N-terminal 6xHis-tagged full length human PRMT5/MEP50 expressed in sf21 cells using S-Adenosyl-L-methionine as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50463126(CHEMBL4238599)
Affinity DataKd:  13nMAssay Description:Binding affinity to heterodimer of N-terminal His-tagged maltose binding protein-fused MYC (unknown origin) expressed in Escherichia coli/MAX bHLH-LZ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50653056(CHEMBL5722954)
Affinity DataKd:  33nMAssay Description:Displacement of kinase tracer 236 from CDK9/Cyclin T1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50615273(CHEMBL365617 | CHEBI:47273 | VER-49009)
Affinity DataKd:  78nMAssay Description:Binding affinity to HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMAssay Description:Binding affinity to PRC2 complex of EZH2-EED-SUZ12 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataKd:  96nMAssay Description:Displacement of kinase tracer 236 from CDK7/Cyclin H/MAT1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  163nMAssay Description:Binding affinity to human HSPA1B/HSPA1A incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataKd:  241nMAssay Description:Binding affinity to N-terminal 6xHis-tagged full length human PRMT5/MEP50 expressed in sf21 cells using S-Adenosyl-L-methionine as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50391814(CHEMBL2146901)
Affinity DataKd:  330nMAssay Description:Binding affinity to human PPARgamma-LBD (206 to 477 residues)/human RXRalpha-LBD (224 to 462 residues) heterodimer assessed as dissociation constant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50644132(CHEMBL5571674)
Affinity DataKd:  400nMAssay Description:Binding affinity to biotinylated PRMT5/MEP50 complex (unknown origin) in presence of MTA by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50421673(CHEMBL5283441)
Affinity DataKd:  440nMAssay Description:Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50524839(CHEMBL4466328)
Affinity DataKd:  530nMAssay Description:Binding affinity to p300-CBP (unknown origin) protein protein interaction assessed as dissociation constant by tryptophan fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM11324(CHEMBL375530 | (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,...)
Affinity DataKd:  614nMAssay Description:Displacement of kinase tracer 236 from CDK9/Cyclin T1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50030474(US9562012, rosiglitazone | CHEBI:50122 | Avandamet...)
Affinity DataKd:  650nMAssay Description:Binding affinity to human PPARgamma-LBD (206 to 477 residues)/human RXRalpha-LBD (224 to 462 residues) heterodimer assessed as dissociation constant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50421686(CHEMBL5282194)
Affinity DataKd:  910nMAssay Description:Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50421676(CHEMBL5283475)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.45E+3nMAssay Description:Binding affinity to human HSPA1B/HSPA1A incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50628482(CHEMBL5421300)
Affinity DataKd:  1.93E+3nMAssay Description:Binding affinity to trypsin (unknown origin) assessed as dissociation constant by surface plasmon resonance imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50421683(CHEMBL5283041)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM11324(CHEMBL375530 | (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,...)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of kinase tracer 236 from CDK7/Cyclin H/MAT1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataKd:  1.32E+4nMAssay Description:Binding affinity to METTL3/METTL14 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50653056(CHEMBL5722954)
Affinity DataKd:  1.60E+4nMAssay Description:Displacement of kinase tracer 236 from CDK7/Cyclin H/MAT1 (unknown origin) assessed as dissociation constant incubated for 1 hr by LanthScreen Eu kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50481594(CHEMBL5268220)
Affinity DataKd:  2.11E+4nMAssay Description:Binding affinity to HSP90 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50639229(CHEMBL5558178)
Affinity DataKd:  2.64E+4nMAssay Description:Binding affinity to CDK9/Cyclin T1 (unknown origin) assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50405644(CHEMBL5281169)
Affinity DataKd:  2.74E+4nMAssay Description:Binding affinity to NT-647 labelled recombinant HSP90 (unknown origin) C-terminal domain assessed as dissociation constant by microscale thermophores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50246253(AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...)
Affinity DataKd:  1.80E+6nMAssay Description:Binding affinity to CDK9/Cyclin T1 (unknown origin) assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details