Compile Data Set for Download or QSAR
Report error Found 14 of ic50 for monomerid = 202791
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 0.650nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 0.652nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 0.652nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 0.652nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 0.800nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 0.800nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 3.11nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 3.11nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 3.11nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 3.11nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 4.70nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 4.70nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 202791BDBM202791(US9694016, 138 | US9242969, 138 | US10245267, Exam...)
Affinity DataIC50: 4.70nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent