Compile Data Set for Download or QSAR
Report error Found 3 of ic50 for monomerid = 228153
LigandPNGBDBM228153((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 98.1nMpH: 7.5Assay Description:N-terminally His-tagged PI3K alpha (Cat. No. PV4789; 0.49 mg/ml), Alexa Fluor 647 labeled kinase Tracer 314 (Cat. No. PV6087), Biotin anti-His Tag an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2018
Entry Details
US Patent

TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM228153((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 353nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM228153((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)
Affinity DataIC50: 751nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed