Compile Data Set for Download or QSAR
Report error Found 7 of ic50 for monomerid = 50456348
TargetMitogen-activated protein kinase 1/3(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50456348BDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ERK1/2 phosphorylation in human A375 cells harboring BRAF V600E mutant after 4 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50456348BDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50456348BDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human N-terminal MAHHHHHH-tagged ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50456348BDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50456348BDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 50456348BDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3.10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1/3(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50456348BDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells harboring BRAF V600E mutant assessed as suppression of RSK phosphorylation after 4 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed