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TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Nuvation Bio

US Patent
LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  3.5nMAssay Description:CDK5 (p25): IC50 values of compounds against CDK5 (p25) were determined by Z′-LYTE™. These screening assays were performed at Invitrogen L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCyclin-K/Cyclin-dependent kinase 9(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  4nMAssay Description:CDK9 (cyclin K): IC50 values of compounds against CDK9 (cyclin K) were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen Life Te...More data for this Ligand-Target Pair
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  4.60nMAssay Description:CDK5 (p25): IC50 values of compounds against CDK5 (p25) were determined by Z′-LYTE™. These screening assays were performed at Invitrogen L...More data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
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LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  5.80nMAssay Description:CDK1 (cyclin B): IC50 values of compounds against CDK1 (cyclin B) were determined by Z′-LYTE™. These screening assays were performed at In...More data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  9nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
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TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  14nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
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TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50:  96nMAssay Description:CDK7 (cyclin H): IC50 values of compounds against CDK7 (cyclin H) were determined by Adapta™ Assay at Invitrogen Life Technologies (Grand Island...More data for this Ligand-Target Pair
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LigandPNGBDBM525729(US11174252, Compound 24)
Affinity DataIC50: >1.00E+4nMAssay Description:PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent