Compile Data Set for Download or QSAR
Report error Found 2 of ki for monomerid = 258909
TargetBeta-secretase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM258909(US9499502, 9j)
Affinity DataKi:  0.600nM ΔG°:  -53.5kJ/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
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Date in BDB:
11/20/2017
Entry Details
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TargetBeta-secretase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM258909(US9499502, 9j)
Affinity DataKi:  16nM ΔG°:  -45.2kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent