Compile Data Set for Download or QSAR
Report error Found 2 Enz. Inhib. hit(s) with Target = '17-beta-hydroxysteroid dehydrogenase type 1' and Ligand = 'BDBM17290'
LigandPNGBDBM17290(EM1745 | E2-adenosine hybrid compound, 8 | [5-(6-a...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.5 T: 2°CAssay Description:For steady-state kinetic study of hybrid inhibitors, a Fluorolog 3 instrument was used to monitor the fluorescent signal of NADPH formed during estra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
LigandPNGBDBM17290(EM1745 | E2-adenosine hybrid compound, 8 | [5-(6-a...)
Affinity DataIC50: 52nMpH: 7.4 T: 2°CAssay Description:The enzymatic reaction was performed in the reaction buffer containing substrate, [14C]-estrone, and the test inhibitors. After the reaction, radiola...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed