Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 4' and Ligand = 'BDBM50122872'
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKd:  2nMAssay Description:Binding affinity to 5-HT4 receptor (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at recombinant human 5-HT4E receptor expressed in CHO cells assessed as induction of c-AMP accumulation after 4 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  7.5nMAssay Description:Tested for agonist activity against 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Suven Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  26nMAssay Description:Partial agonist activity at rat 5HT4E receptor expressed in HEK293 cells assessed as cAMP accumulation incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at 5-HT4E receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Suven Life Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at rat 5HT4e receptor expressed in HEK293 cells assessed as cAMP level after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  44.1nMAssay Description:Prior to these competition studies, a series of saturation curves were performed in order to check whether the pharmacological parameters Kd, Bmax an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  110nMAssay Description:Tested for selectivity for 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-GR113808 from full-length human 5-HT4R stably expressed in HEK293 cell membrane by MicroBeta2 Reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Tested for selectivity for 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Beijing Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122872BDBM50122872(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Tested for selectivity for 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed