Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A2a' and Ligand = 'BDBM50595579'
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataEC50:  0.900nMAssay Description:Antagonist activity at wild type human A2AAR expressed in CHO cells assessed as inhibition of CGS21680-induced cAMP accumulation preincubated for 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H] ZM241385 from human A2AAR S227A mutant expressed in CHO cells assessed as dissociation constant incubated for 60 mins by radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKd:  2nMAssay Description:Displacement of [3H] ZM241385 from wild type human A2AAR expressed in CHO cells assessed as dissociation constant incubated for 60 mins by radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKd:  2.70nMAssay Description:Displacement of [3H] ZM241385 from human A2AAR S277A/H278A double mutant expressed in CHO cells assessed as dissociation constant incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKd:  2.90nMAssay Description:Displacement of [3H] ZM241385 from human A2AAR H278A mutant expressed in CHO cells assessed as dissociation constant incubated for 60 mins by radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKi:  7.70nMAssay Description:Displacement of CGS2168 from recombinant human A2AAR expressed in HEK293 cell membrane assessed as inhibition constant incubated for 60 mins by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKi:  18nMAssay Description:Displacement of [3H] ZM241385 from wild type human A2AAR expressed in CHO cells assessed as inhibition constant incubated for 60 mins by Cheng-Prusof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKi:  19nMAssay Description:Displacement of [3H] ZM241385 from human A2AAR H278A mutant expressed in CHO cells assessed as inhibition constant incubated for 60 mins by Cheng-Pru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKi:  22nMAssay Description:Displacement of [3H] ZM241385 from human A2AAR S227A mutant expressed in CHO cells assessed as inhibition constant incubated for 60 mins by Cheng-Pru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataKi:  56nMAssay Description:Displacement of [3H] ZM241385 from human A2AAR S277A/H278A double mutant expressed in CHO cells assessed as inhibition constant incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataEC50:  94nMAssay Description:Antagonist activity at human A2AAR S227A mutant expressed in CHO cells assessed as inhibition of CGS21680-induced cAMP accumulation preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataEC50:  109nMAssay Description:Antagonist activity at human A2AAR H278A mutant A2AAR expressed in CHO cells assessed as inhibition of CGS21680-induced cAMP accumulation preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Southern California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595579BDBM50595579(CHEMBL5203469)
Affinity DataEC50:  8.39E+3nMAssay Description:Antagonist activity at human A2AAR S277A/H278A double mutant expressed in CHO cells assessed as inhibition of CGS21680-induced cAMP accumulation prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed