Report error Found 83 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A3' and Ligand = 'BDBM21220'
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 154nMAssay Description:Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based Na...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 89nMAssay Description:Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 155nMAssay Description:Stimulation of [35S]GTP-gamma-S, against human adenosine A3 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 26nMAssay Description:Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 85nMAssay Description:Effective concentration for stimulation of [35S]GTP-gamma-S, binding at human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 1.04E+4nMAssay Description:Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 78nMAssay Description:Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 3.03E+5nMAssay Description:Agonist efficacy as effective concentration to stimulate binding of [35S]GTP-gamma-S, by activation of human A3AR receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 63nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 350nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 63nMAssay Description:Agonist activity at Homo sapiens (human) adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 188nMAssay Description:Partial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured afte...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation ...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 0.117nMAssay Description:Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by me...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 48nMAssay Description:Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by L...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataEC50: 177nMAssay Description:Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataIC50: 0.933nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-ind...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataIC50: 6.56E+4nMAssay Description:Inhibition of forskolin-stimulated cAMP accumulation in chinese hamster ovary cell membranes expressing human adenosine A3 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Binding affinity towards human Adenosine A3 receptor wild typeMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Binding affinity towards Adenosine A3 receptor (W243 A mutant receptor)More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of [3H]NECA binding to human adenosine A3 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:[3H]NECA saturation binding in CHO cells expressing human Adenosine A3 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Displacement of [3H]NECA from human A3AR expressed in human HeLa cell membrane assessed as inhibition constant incubated for 180 mins by competitive ...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Binding affinity to human recombinant adenosine A3 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 8.20nMAssay Description:Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 10.2nMAssay Description:Displacement of [125I]ABA from human adenosine A3 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Ability to displace radioligand [125I]AB-MECA from membrane of HEK 293 cells stably transfected with human adenosine A3 receptor cDNAMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Binding affinity against human adenosine A3 receptor expressed on HEK293 cells using [125I]I-AB-MECAMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB MECA displacement.More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Displacement of [3H]HEMADO from human adenosine receptor A3 expressed in CHO cell membranes after 3 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Displacement of [3H]-HEMADO from human A3 receptor stably expressed in CHO cell membranes by radioligand competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from mouse A3A adenosine receptor expressed in CHO cell membranes after ...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cells after 60 mins gamma counterMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
TargetAdenosine receptor A3(Human)
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Disease
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
