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Report error Found 3 Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM31777'
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Universidad de Buenos Aires

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31777BDBM31777(thieno[2,3-d]pyrimidine deriv., 2)
Affinity DataIC50: 2nMAssay Description:Inhibition of Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Universidad de Buenos Aires

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31777BDBM31777(thieno[2,3-d]pyrimidine deriv., 2)
Affinity DataIC50: 2.10nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Universidad de Buenos Aires

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31777BDBM31777(thieno[2,3-d]pyrimidine deriv., 2)
Affinity DataIC50: 90nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed