Compile Data Set for Download or QSAR
Report error Found 2 Enz. Inhib. hit(s) with Target = 'Bifunctional purine biosynthesis protein ATIC' and Ligand = 'BDBM22585'
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 22585BDBM22585(1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...)
Affinity DataKi:  130nM ΔG°:  -38.9kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 22585BDBM22585(1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed