Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 5' and Ligand = 'BDBM50336345'
TargetC-C chemokine receptor type 5(Mouse)
Nirma University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataKd:  3nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 5.62nMAssay Description:Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 5.80nMAssay Description:Displacement of MIP-1alpha from human CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 46nMAssay Description:Antagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 5.60E+3nMAssay Description:Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rat CCR5 assessed as inhibition of RANTES-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Rabbit)
Ono Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336345BDBM50336345(APLAVIROC | CHEMBL1668019 | 4-(4-(((R)-1-butyl-3-(...)
Affinity DataIC50: 3.40E+4nMAssay Description:Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed