Compile Data Set for Download or QSAR
Report error Found 2 Enz. Inhib. hit(s) with Target = 'COP9 signalosome complex subunit 5' and Ligand = 'BDBM224012'
TargetCOP9 signalosome complex subunit 5(Human)
California Institute of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50: 3.00E+4nMpH: 7.5Assay Description:Csn5 activity was measured using purified CSN complex and the fluorescent substrate OGNedd8–SCFSkp2, in which a unique cysteine engineered into ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
California Institute of Technology

LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50: 3.00E+4nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent