Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with Target = 'Cyclin-T1/Cyclin-dependent kinase 9' and Ligand = 'BDBM50528817'
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528817BDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataKd:  0.0894nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528817BDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculovirus expression system in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528817BDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528817BDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 4nMAssay Description:Inhibition of full length human CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculovirus expression system in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528817BDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin) in presence of ATP by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528817BDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 13nMAssay Description:The DMSO diluted compounds and the control compounds Dinaciclib, JSH-009, BAY-1211152, AZD4573 (all purchased from MCE, China) were mixed with the de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528817BDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataKd:  711nMAssay Description:Binding affinity to human CDK9/CyclinT assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed