Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with Target = 'Cytosol aminopeptidase' and Ligand = 'BDBM23971'
TargetCytosol aminopeptidase(Bovine)
Merck Sharpe and Dohme

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Bovine)
Merck Sharpe and Dohme

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataIC50: 0.5nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against Leucine aminopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Bovine)
Merck Sharpe and Dohme

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataKi:  500nMAssay Description:Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Pig)
National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 60 mins measured every 3 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Pig)
National Institute of Public Health-National Institute of Hygiene

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of porcine kidney microsomal LAP using l-leucine-7-amido-4-methylcoumarin as substrate incubated for 10 hrs measured every 6 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23971BDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibitory concentration against adipocyte-derived leucine aminopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed