Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-I' and Ligand = 'BDBM50196926'
TargetEukaryotic initiation factor 4A-I(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196926BDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length 6xHis-tagged EIF4A1 (unknown origin) by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196926BDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196926BDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataIC50: 47nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196926BDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataIC50: 135nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196926BDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataKd:  156nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic initiation factor 4A-I(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196926BDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataIC50: 231nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)