Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Gag-Pol polyprotein' and Ligand = 'BDBM1434'
TargetGag-Pol polyprotein(HIV-1)
Yunnan University

US Patent
LigandPNGBDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataEC50:  13nMAssay Description:C8166 cells infected with HIV-1 were used for determining the anti-HIV biological activity at the cellular level. The specific method was described b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetGag-Pol polyprotein(HIV-1)
Jaipur National University

LigandPNGBDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 100nMT: 2°CAssay Description:To a lysis buffer (20 μl), 4-6 ng recombinant HIV-1-RT was added in separate reaction tubes. Lysis buffer without HIV-1-RT was used as a negative ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2017
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
Jaipur National University

LigandPNGBDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 300nMpH: 7.8 T: 2°CAssay Description:HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
Shandong University

LigandPNGBDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 690nMT: 2°CAssay Description:A reverse transcriptase (RT) assay kit produced by Roche was selected for the RT inhibition assay. All the reagents for performing the RT reaction ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed