Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase p300' and Ligand = 'BDBM50542060'
TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2 | ...)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to recombinant full length EP300 (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2 | ...)
Affinity DataIC50: 8.10nMAssay Description:Binding affinity to recombinant N-terminal His-tagged EP300 HAT domain (unknown origin) (1287 to 1666 residues) expressed in Escherichia coli incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2 | ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of EP300 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2 | ...)
Affinity DataIC50: 280nMAssay Description:SensoLyte HAT (p300) Assay Kit (ANASPEC, AS-72172) was used to assess the HAT activity inhibiting capability of a HAT inhibitor. Specifically, 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2 | ...)
Affinity DataIC50: 1.80E+3nMAssay Description:The full length p300 SPA assay was run following the same protocol as p300 HAT SPA assay, but used 6 nM purified full length p300 (purchased from Act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
Go to US Patent