Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 1' and Ligand = 'BDBM50276074'
TargetHistone deacetylase 1(Human)
Genentech

LigandPNGBDBM50276074(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,7-d...)
Affinity DataIC50: 7.93nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Genentech

LigandPNGBDBM50276074(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,7-d...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Genentech

LigandPNGBDBM50276074(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,7-d...)
Affinity DataKd:  24.6nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Genentech

LigandPNGBDBM50276074(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,7-d...)
Affinity DataKd:  48nMAssay Description:Binding affinity to human HDAC1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed