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Report error Found 3 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM370488'
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370488(1-(4,4-difluorocyclohexyl)-2-(6-fluoro-5H- imidazo...)
Affinity DataEC50:  93nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370488(1-(4,4-difluorocyclohexyl)-2-(6-fluoro-5H- imidazo...)
Affinity DataIC50: 100nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370488(1-(4,4-difluorocyclohexyl)-2-(6-fluoro-5H- imidazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent