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Report error Found 13 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM18351'
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  4.70E+4nMAssay Description:Inhibitory activity against beta-glucosidase of sweet almondMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  7.90E+4nM ΔG°:  -24.4kJ/mole IC50: 2.40E+5nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  7.90E+4nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibitory activity was determined against almonds Beta-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of human beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 2.10E+5nMAssay Description:Inhibition of bovine liver beta-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of human lysosomal beta-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibitory activity was determined against Escherichia coli beta galactosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  3.00E+5nMpH: 5.0Assay Description:Competitive Inhibition constant on almonds beta Glucosidase at pH 5.0More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  3.00E+5nMpH: 5.0Assay Description:Competitive Inhibition constant on almonds beta Glucosidase at pH 5.0More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of Beta-glucosidase activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Technische Universit£T Berlin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18351BDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 5.06E+5nMAssay Description:Displacement of 4-methylumbelliferyl from human GBA by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed