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Report error Found 6 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM50078114'
TargetLysosomal acid glucosylceramidase(Mouse)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50078114BDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataIC50: 1.10E+3nMAssay Description:Compound was tested for inhibitory activity against beta-glucocerebrosidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandChemical structure of BindingDB Monomer ID 50078114BDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  7.73E+3nM IC50: 1.20E+4nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Mouse)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50078114BDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataIC50: 8.90E+3nMAssay Description:Specific inhibitory activity against Glucosylceramidase in mouse liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandChemical structure of BindingDB Monomer ID 50078114BDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataIC50: 9.49E+3nMAssay Description:Inactivation solutions contained a final concentration of 16.55 nM of Cerezyme (Recombinant GCase) in 200 μL of Reaction Buffer (50 mM acetate, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandChemical structure of BindingDB Monomer ID 50078114BDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  5.30E+4nM ΔG°:  -25.4kJ/mole IC50: 9.49E+3nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandChemical structure of BindingDB Monomer ID 50078114BDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  1.40E+5nMAssay Description:Inactivation solutions contained a final concentration of 16.55 nM of Cerezyme (Recombinant GCase) in 200 μL of Reaction Buffer (50 mM acetate, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2024
Entry Details
US Patent