Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M1' and Ligand = 'BDBM50296345'
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataKi:  0.0130nMAssay Description:Displacement of [3H]-NMS from human recombinant M1 receptor expressed in CHO cells after 24 hrs by filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataIC50: 0.0316nMAssay Description:Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M1 receptor in cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataIC50: 0.220nMAssay Description:Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed