Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with Target = 'SYK Kinase' and Ligand = 'BDBM225517'
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 0.412nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 0.746nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 0.925nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.21nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.23nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.35nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.44nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225517(GTC000226A | GTC000226B)
Show SMILES OCCCN(c1ccnc(Nc2ccc3CNS(=O)(=O)c3c2)n1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C21H21N7O3S/c29-10-2-9-28(18-4-1-3-17-16(18)13-23-27-17)20-7-8-22-21(26-20)25-15-6-5-14-12-24-32(30,31)19(14)11-15/h1,3-8,11,13,24,29H,2,9-10,12H2,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.52nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB