Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase mTOR' and Ligand = 'BDBM50429701'
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataKd:  0.140nMAssay Description:Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 2.80nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 20nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent