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Found 4 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ITK/TSK' and Ligand = 'BDBM50399459'
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399459(CHEMBL2179805)
Affinity DataIC50:  2nMAssay Description:Covalent inhibition of ITK in presence of 5 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399459(CHEMBL2179805)
Affinity DataIC50:  2nMAssay Description:Covalent inhibition of ITK in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399459(CHEMBL2179805)
Affinity DataIC50:  31nMAssay Description:Covalent inhibition of ITK in human Jurkat cells assessed as inhibition of anti-CD3 antibody-stimulated PLCgamma phosphorylation pre-incubated before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50399459(CHEMBL2179805)
Affinity DataIC50:  48nMAssay Description:Covalent inhibition of ITK in human whole blood assessed as inhibition of anti-CD3 antibody-stimulated IL2 production pre-incubated before anti-CD3 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed