Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM159756'
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 2.70nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 3nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent