Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM316639'
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 316639BDBM316639(US9617258, Example 130 | US11111242, Example 130 |...)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 316639BDBM316639(US9617258, Example 130 | US11111242, Example 130 |...)
Affinity DataIC50: 75nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 316639BDBM316639(US9617258, Example 130 | US11111242, Example 130 |...)
Affinity DataIC50: 75.2nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 316639BDBM316639(US9617258, Example 130 | US11111242, Example 130 |...)
Affinity DataIC50: 75.2nMAssay Description:JAK Caliper Enzyme Assay at 4 μM: Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 316639BDBM316639(US9617258, Example 130 | US11111242, Example 130 |...)
Affinity DataIC50: 75.2nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 316639BDBM316639(US9617258, Example 130 | US11111242, Example 130 |...)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed