Compile Data Set for Download or QSAR
Report error Found 181 of Enz. Inhib. data with enzyme = '11-beta-hydroxysteroid dehydrogenase 1' and Substrate = 'BDBM13739'
LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM28369(N-{4-[(1-cyanocyclopropyl)methyl]cyclohexyl}-N-cyc...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50: 0.700nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM28367(N-[4-(2-cyano-2,2-dimethylethyl)cyclohexyl]-N-cycl...)
Affinity DataIC50: 0.880nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM29864(N-(Pyridin-2-yl) arylsulfonamide, 26)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM29839(spiro-carboxamide scaffold, 12)
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29863(N-(Pyridin-2-yl) arylsulfonamide, 25)
Affinity DataKi:  1.70nM ΔG°:  -11.8kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM28374(N-{4-[(1-carbamoylcyclopropyl)methyl]cyclohexyl}-N...)
Affinity DataIC50: 1.70nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM29862(N-(Pyridin-2-yl) arylsulfonamide, 24)
Affinity DataKi:  1.90nM ΔG°:  -11.8kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM28368(N-[4-(2-cyano-2,2-dimethylethyl)cyclohexyl]-N-cycl...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM28371(N-[4-(2-carbamoylethyl)cyclohexyl]-N-cyclopropyl-4...)
Affinity DataIC50: 2.40nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM28366(N-[4-(2-cyanoethyl)cyclohexyl]-N-cyclopropyl-4-[(2...)
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)
Affinity DataKi:  3nM ΔG°:  -11.5kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM13746(2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5...)
Affinity DataKi:  3nM ΔG°:  -11.5kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM29834(spiro-carboxamide scaffold, 7)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13760((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 3nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM28373(N-[4-(2-carbamoyl-2,2-dimethylethyl)cyclohexyl]-N-...)
Affinity DataIC50: 3.80nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13768(N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]ada...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13756((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM32567(arylsulfonylpiperazine, 39)
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13749((5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...)
Affinity DataKi:  4nM ΔG°:  -11.3kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM32571(arylsulfonylpiperazine, 43)
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29860(N-(Pyridin-2-yl) arylsulfonamide, 22)
Affinity DataKi:  4nM ΔG°:  -11.3kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13761((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM29866(N-(Pyridin-2-yl) arylsulfonamide, 28)
Affinity DataKi:  4.80nM ΔG°:  -11.2kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM13756((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM28363(N-[4-(cyanomethyl)cyclohexyl]-N-cyclopropyl-4-[(2S...)
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM29858(N-(Pyridin-2-yl) arylsulfonamide, 20)
Affinity DataKi:  5.80nM ΔG°:  -11.1kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM13760((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13761((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 6nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM29833(spiro-carboxamide scaffold, 6)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM32568(arylsulfonylpiperazine, 40)
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29861(N-(Pyridin-2-yl) arylsulfonamide, 23)
Affinity DataKi:  6.60nM ΔG°:  -11.0kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM13748(2-((S)-1-(2-bromophenyl)ethylamino)-5-isopropyl-5-...)
Affinity DataKi:  7nM ΔG°:  -11.0kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM28364(N-[4-(cyanomethyl)cyclohexyl]-N-cyclopropyl-4-[(2S...)
Affinity DataIC50: 7.60nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM13757((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 8nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13769(2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[...)
Affinity DataIC50: 8nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13747(2-((S)-1-(2-chlorophenyl)ethylamino)-5-isopropyl-5...)
Affinity DataKi:  8nM ΔG°:  -10.9kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13757((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 8nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13750((5R)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-met...)
Affinity DataKi:  9nM ΔG°:  -10.9kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM32570(arylsulfonylpiperazine, 42)
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM29865(N-(Pyridin-2-yl) arylsulfonamide, 27)
Affinity DataKi:  9.80nM ΔG°:  -10.8kcal/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13772(2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)
Affinity DataIC50: 10nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM13772(2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)
Affinity DataIC50: 11nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM28375(N-{1-[(1-cyanocyclopropyl)methyl]piperidin-4-yl}-N...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13766((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 11nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
LigandPNGBDBM28372(N-[4-(2-carbamoylethyl)cyclohexyl]-N-cyclopropyl-4...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
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