Compile Data Set for Download or QSAR
Report error Found 108 of Enz. Inhib. data with enzyme = '5-hydroxytryptamine receptor 6' and Substrate = 'BDBM21342'
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34143(CHEMBL175835 | E-6837)
Affinity DataKi:  0.700nM ΔG°:  -13.0kcal/mole EC50:  0.290nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34144((R)-5a | WAY-466)
Affinity DataKi:  1nM ΔG°:  -12.8kcal/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataKi:  0.400nM ΔG°:  -13.3kcal/mole EC50:  4.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28574(3-amino-N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6...)
Affinity DataKi:  0.5nM ΔG°:  -12.6kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28586(1-{3-[(3-chlorophenyl)methoxy]-2-methylphenyl}pipe...)
Affinity DataKi:  0.600nM ΔG°:  -12.4kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28583(CHEMBL431298 | SB 271046 | 5-chloro-N-[4-methoxy-3...)
Affinity DataKi:  0.660nM ΔG°:  -12.4kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34147(CHEMBL425196 | pyrrolidinylindole, 6)
Affinity DataKi:  1nM ΔG°:  -12.8kcal/mole EC50:  53.3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21351(4-{[3-(2-aminoethyl)-1H-indole-1-]sulfonyl}aniline...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/mole EC50:  91nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28575(3-(methylamino)-N-[1-(naphthalene-1-sulfonyl)-1H-i...)
Affinity DataKi:  1.20nM ΔG°:  -12.0kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28580(N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]pipe...)
Affinity DataKi:  1.30nM ΔG°:  -12.0kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28584(1-[3-(benzyloxy)-2-methylphenyl]piperazine | tolyl...)
Affinity DataKi:  1.30nM ΔG°:  -12.0kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28635(2-methyl-3-(piperidin-4-yl)phenyl naphthalene-1-su...)
Affinity DataKi:  1.5nM ΔG°:  -12.0kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28576(3-(dimethylamino)-N-[1-(naphthalene-1-sulfonyl)-1H...)
Affinity DataKi:  1.80nM ΔG°:  -11.8kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34148(CHEMBL371292 | piperidinylindole, 7)
Affinity DataKi:  2nM ΔG°:  -12.3kcal/mole EC50:  24nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/mole EC50:  6.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34141(CHEMBL76237 | MS-245)
Affinity DataKi:  2nM ΔG°:  -12.3kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2nM ΔG°:  -12.3kcal/mole EC50:  6.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28577(3-(diethylamino)-N-[1-(naphthalene-1-sulfonyl)-1H-...)
Affinity DataKi:  2.10nM ΔG°:  -11.7kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34152(CHEMBL362628 | E-6801)
Affinity DataKi:  2.20nM ΔG°:  -12.3kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28579(N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]pipe...)
Affinity DataKi:  2.30nM ΔG°:  -11.7kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28620(2-[1-(3-chlorophenyl)-2,2,2-trifluoroethoxy]-3-met...)
Affinity DataKi:  2.40nM ΔG°:  -11.8kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28594(4-{3-[(3-fluorophenyl)methoxy]-2-methylphenyl}pipe...)
Affinity DataKi:  2.5nM ΔG°:  -11.6kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28636(2-methyl-3-(piperidin-4-yl)phenyl naphthalene-2-su...)
Affinity DataKi:  2.70nM ΔG°:  -11.7kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28603(4-{3-[(1S)-1-(3-chlorophenyl)ethoxy]-2-methylpheny...)
Affinity DataKi:  2.80nM ΔG°:  -11.5kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34149(CHEMBL94422 | N-benzenesulfonylgramine antagonist,...)
Affinity DataKi:  3nM ΔG°:  -12.1kcal/mole EC50:  880nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34156(indenylsulfonamide, 28)
Affinity DataKi:  3nM ΔG°:  -12.1kcal/mole IC50: 1.60E+3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28595(4-{3-[(3-chlorophenyl)methoxy]-2-methylphenyl}pipe...)
Affinity DataKi:  3.30nM ΔG°:  -11.4kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28623(4-[3-(3-chlorophenoxymethyl)-2-methylphenyl]piperi...)
Affinity DataKi:  3.5nM ΔG°:  -11.5kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28621(3-methyl-4-(piperidin-4-yl)-2-[2,2,2-trifluoro-1-(...)
Affinity DataKi:  4.30nM ΔG°:  -11.4kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34153(CHEMBL476006 | indenylsulfonamide, 14)
Affinity DataKi:  4.5nM ΔG°:  -11.8kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28628(2-methyl-3-(piperidin-4-yl)phenyl 2-chlorobenzene-...)
Affinity DataKi:  5.80nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21345(2-{1-[(3-chlorobenzene)sulfonyl]-1H-indol-3-yl}eth...)
Affinity DataKi:  6nM ΔG°:  -11.1kcal/mole EC50:  109nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21354(2-{1-[(5-chlorothiophene-2-)sulfonyl]-1H-indol-3-y...)
Affinity DataKi:  6nM ΔG°:  -11.1kcal/mole EC50:  181nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28619(2-[1-(3-chlorophenyl)propoxy]-3-methyl-4-(piperidi...)
Affinity DataKi:  6.40nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28624(4-[3-(3-fluorophenoxymethyl)-2-methylphenyl]piperi...)
Affinity DataKi:  6.5nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28601(4-{3-[(1S)-1-(3-fluorophenyl)ethoxy]-2-methylpheny...)
Affinity DataKi:  6.90nM ΔG°:  -11.0kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21353(2-{1-[(3,4-dimethoxybenzene)sulfonyl]-1H-indol-3-y...)
Affinity DataKi:  7nM ΔG°:  -11.0kcal/mole EC50:  17.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21355(2-{1-[(5-bromothiophene-2-)sulfonyl]-1H-indol-3-yl...)
Affinity DataKi:  7nM ΔG°:  -11.0kcal/mole EC50:  54nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28572(3-amino-N-[1-(naphthalene-1-sulfonyl)-1H-indazol-4...)
Affinity DataKi:  7.90nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21349(2-{1-[(4-methylbenzene)sulfonyl]-1H-indol-3-yl}eth...)
Affinity DataKi:  8nM ΔG°:  -10.9kcal/mole EC50:  191nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21365(3-[(E)-{1-[1-(benzenesulfonyl)-1H-indol-3-yl]ethyl...)
Affinity DataKi:  8nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28607(2-[(3-chlorophenyl)methoxy]-3-methyl-4-(piperidin-...)
Affinity DataKi:  8.10nM ΔG°:  -11.0kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28589(1-{3-[(3,4-difluorophenyl)methoxy]-2-methylphenyl}...)
Affinity DataKi:  9.30nM ΔG°:  -10.8kcal/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21357(5-{[3-(2-aminoethyl)-1H-indole-1-]sulfonyl}-4-meth...)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/mole EC50:  9.60nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34146(pyrrolidinylindole, (S)-5b)
Affinity DataKi:  10nM ΔG°:  -11.3kcal/mole EC50:  21.6nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21341(2-[1-(benzenesulfonyl)-1H-indol-3-yl]ethan-1-amine...)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/mole EC50:  73nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34151(CHEMBL372109 | N-arenesulfonylindole antagonist, 1...)
Affinity DataKi:  10nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM21347(2-{1-[(4-chlorobenzene)sulfonyl]-1H-indol-3-yl}eth...)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/mole EC50:  174nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM34154(CHEMBL515307 | indenylsulfonamide, 15)
Affinity DataKi:  10nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

LigandPNGBDBM28631(2-methyl-3-(piperidin-4-yl)phenyl 2-methylbenzene-...)
Affinity DataKi:  10.1nM ΔG°:  -10.9kcal/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
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