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Report error Found 30 of Enz. Inhib. data with enzyme = '5-hydroxytryptamine receptor 7' and Substrate = 'BDBM21342'
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21383(6-[4-(2-phenylphenyl)piperazin-1-yl]-N-(1,2,3,4-te...)
Affinity DataKi:  0.130nM ΔG°:  -14.0kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
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Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21367(CHEMBL225284 | 6-{4-[2-(methylsulfanyl)phenyl]pipe...)
Affinity DataKi:  0.220nM ΔG°:  -13.7kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
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Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21392([3H]-5-carboxamidotryptamine | CHEMBL18840 | 5-car...)
Affinity DataKi:  0.5nM ΔG°:  -13.2kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21384(6-{4-[2-(dimethylamino)phenyl]piperazin-1-yl}-N-(1...)
Affinity DataKi:  0.900nM ΔG°:  -12.8kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21381(6-{4-[2-(propan-2-yl)phenyl]piperazin-1-yl}-N-(1,2...)
Affinity DataKi:  1.10nM ΔG°:  -12.7kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21370(CHEMBL389718 | 6-[4-(2-acetylphenyl)piperazin-1-yl...)
Affinity DataKi:  4.14nM ΔG°:  -11.9kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21368(CHEMBL224820 | 6-[4-(2-methoxyphenyl)piperazin-1-y...)
Affinity DataKi:  6.64nM ΔG°:  -11.6kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21378(6-[4-(2-ethylphenyl)piperazin-1-yl]-N-(1,2,3,4-tet...)
Affinity DataKi:  7.10nM ΔG°:  -11.6kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21371(CHEMBL225512 | 6-[4-(2-hydroxyphenyl)piperazin-1-y...)
Affinity DataKi:  11.4nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  15.2nM ΔG°:  -11.1kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21385(6-{4-[2-(methylamino)phenyl]piperazin-1-yl}-N-(1,2...)
Affinity DataKi:  25.4nM ΔG°:  -10.8kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21374(CHEMBL222477 | 6-[4-(2-chlorophenyl)piperazin-1-yl...)
Affinity DataKi:  40.1nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21375(6-[4-(2-cyanophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...)
Affinity DataKi:  48.7nM ΔG°:  -10.4kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21379(6-[4-(2-propylphenyl)piperazin-1-yl]-N-(1,2,3,4-te...)
Affinity DataKi:  49.6nM ΔG°:  -10.4kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21373(6-[4-(2-nitrophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...)
Affinity DataKi:  63.3nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21372(CHEMBL222188 | 6-(4-phenylpiperazin-1-yl)-N-(1,2,3...)
Affinity DataKi:  65.6nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21389(6-[4-(2-fluorophenyl)piperazin-1-yl]-N-(1,2,3,4-te...)
Affinity DataKi:  131nM ΔG°:  -9.76kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21376(2-{4-[5-(1,2,3,4-tetrahydronaphthalen-1-ylcarbamoy...)
Affinity DataKi:  229nM ΔG°:  -9.42kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21390(6-[4-(pyridin-2-yl)piperazin-1-yl]-N-(1,2,3,4-tetr...)
Affinity DataKi:  278nM ΔG°:  -9.30kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21377(CHEMBL387738 | 6-[4-(2-methanesulfonylphenyl)piper...)
Affinity DataKi:  298nM ΔG°:  -9.25kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21387(6-[4-(2-acetamidophenyl)piperazin-1-yl]-N-(1,2,3,4...)
Affinity DataKi:  338nM ΔG°:  -9.18kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21382(6-[4-(2-tert-butylphenyl)piperazin-1-yl]-N-(1,2,3,...)
Affinity DataKi:  538nM ΔG°:  -8.89kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Wyeth Research

LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  679nM ΔG°:  -8.32kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21380(6-[4-(2-butylphenyl)piperazin-1-yl]-N-(1,2,3,4-tet...)
Affinity DataKi:  2.81E+3nM ΔG°:  -7.87kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21388(6-[4-(2-methanesulfonamidophenyl)piperazin-1-yl]-N...)
Affinity DataKi:  4.25E+3nM ΔG°:  -7.62kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Wyeth Research

LigandPNGBDBM28574(3-amino-N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6...)
Affinity DataKi:  5.10E+3nM ΔG°:  -7.14kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Wyeth Research

LigandPNGBDBM28580(N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]pipe...)
Affinity DataKi:  5.80E+3nM ΔG°:  -7.07kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Wyeth Research

LigandPNGBDBM28579(N-[1-(naphthalene-1-sulfonyl)-1H-indazol-6-yl]pipe...)
Affinity DataKi:  6.90E+3nM ΔG°:  -6.97kcal/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21391(1-oxido-2-{4-[5-(1,2,3,4-tetrahydronaphthalen-1-yl...)
Affinity DataKi:  8.03E+3nM ΔG°:  -7.23kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Universita Degli Studi Di Bari

LigandPNGBDBM21386(6-[4-(2-aminophenyl)piperazin-1-yl]-N-(1,2,3,4-tet...)
Affinity DataKi:  8.18E+3nM ΔG°:  -7.21kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2008
Entry Details Article
PubMed