Compile Data Set for Download or QSAR
Report error Found 34 of Enz. Inhib. data with enzyme = '72 kDa type IV collagenase' and Substrate = 'MMP Fluorogenic Peptide Substrate'
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11883(1-Cyclopropyl-N-hydroxy-4-{[4-(phenylthio)phenyl]-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11870(4-{[4-(4-chlorophenoxy)benzene]sulfonyl}-N-hydroxy...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11873(N-hydroxy-1-methyl-4-[(4-phenoxybenzene)sulfonyl]p...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11889(N-hydroxy-2-methyl-2-[(4-phenoxybenzene)sulfonyl]p...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11874(N-hydroxy-1-(2-methoxyethyl)-4-[(4-phenoxybenzene)...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11876(1-(Cyclopropylmethyl)-N-hydroxy-4-[(4-phenoxypheny...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11878(1-Acetyl-N-hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.130nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11884(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataKi:  0.150nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11866(N-hydroxy-1-[(3-methoxyphenyl)methyl]-4-{[(4-pheno...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11871(tert-butyl 4-(hydroxycarbamoyl)-4-[(4-phenoxybenze...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11864(tert-Butyl 4-[(Hydroxyamino)carbonyl]-4-{[(4-pheno...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11872(N-hydroxy-4-[(4-phenoxybenzene)sulfonyl]piperidine...)
Affinity DataKi:  0.220nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-hydroxy-4-{[(4-phenoxybenzene)sul...)
Affinity DataKi:  0.25nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11882(N-hydroxy-1-(2-methoxyethyl)-4-{[4-(phenylsulfanyl...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11879(N-hydroxy-1-methanesulfonyl-4-[(4-phenoxybenzene)s...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11885(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataKi:  0.330nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11886(1-acetyl-N-hydroxy-4-{[4-(phenylsulfanyl)benzene]s...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11880(N-Hydroxy-1-methyl-4-{[4-(phenylthio)phenyl]sulfon...)
Affinity DataKi:  0.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11881(1-ethyl-N-hydroxy-4-{[4-(phenylsulfanyl)benzene]su...)
Affinity DataKi:  0.800nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11869(4-({[4-(3,4-Dimethylphenoxy)phenyl]sulfonyl}methyl...)
Affinity DataKi:  0.900nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50: 1nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11887(N-hydroxy-1-methanesulfonyl-4-{[4-(phenylsulfanyl)...)
Affinity DataKi:  2nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11888(N-hydroxy-2-[(4-phenoxybenzene)sulfonyl]acetamide ...)
Affinity DataKi:  2.60nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM11865(N-hydroxy-4-{[(4-phenoxybenzene)sulfonyl]methyl}pi...)
Affinity DataKi:  2.80nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50: 3nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM12072(CHEMBL202932 | (R)-[1-(4-Methoxybiphenyl-4-sulfony...)
Affinity DataKi:  5nM ΔG°:  -11.3kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM12077((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50: 450nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandPNGBDBM12073((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  1.20E+3nM ΔG°:  -8.07kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed