Compile Data Set for Download or QSAR
Report error Found 216 of Enz. Inhib. data with enzyme = 'Androgen receptor' and Substrate = 'BDBM18161'
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18161BDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM ΔG°:  -13.8kcal/mole EC50:  5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18524BDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  4.60nM ΔG°:  -11.8kcal/mole EC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18161BDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM ΔG°:  -13.8kcal/mole EC50:  5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18588BDBM18588(6-[(2,2-difluoroethyl)(2,2,2-trifluoroethyl)amino]...)
Affinity DataKi:  1.70nM ΔG°:  -12.4kcal/mole EC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29320BDBM29320(BMS-665139 | oxazolidin-2-imine, 6c)
Affinity DataKi:  0.300nM ΔG°:  -12.9kcal/mole EC50:  0.200nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18161BDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM EC50:  5.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29321BDBM29321(oxazolidin-2-imine, 6d)
Affinity DataKi:  0.200nM ΔG°:  -13.1kcal/mole EC50:  19nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18161BDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.300nM ΔG°:  -13.5kcal/mole EC50:  5.70nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18189BDBM18189((1R,2S,10S,11S,14S,15S,17S)-1-fluoro-14,17-dihydro...)
Affinity DataKi:  5.70nM ΔG°:  -11.7kcal/mole EC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18161BDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.300nM ΔG°:  -12.9kcal/mole EC50:  2.80nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29319BDBM29319(oxazolidin-2-imine, 6b)
Affinity DataKi:  0.300nM ΔG°:  -12.9kcal/mole EC50:  14nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29323BDBM29323(oxazolidin-2-imine, 6f)
Affinity DataKi:  0.300nM ΔG°:  -12.9kcal/mole EC50:  1.40nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18535BDBM18535(6-[ethyl(2,2,2-trifluoroethyl)amino]-4-(trifluorom...)
Affinity DataKi:  7.10nM ΔG°:  -11.6kcal/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18578BDBM18578(6-[bis(2,2-difluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  0.5nM ΔG°:  -13.2kcal/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18579BDBM18579(6-[(2-chloro-2,2-difluoroethyl)(2,2-difluoroethyl)...)
Affinity DataKi:  2.30nM ΔG°:  -12.3kcal/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18605BDBM18605(6-[bis(2,2,2-trifluoroethyl)amino]-4-(difluorometh...)
Affinity DataKi:  0.400nM EC50:  0.5nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18188BDBM18188(4-[(1S,7aR)-1-hydroxy-7-methyl-5-oxo-2,3,5,7a-tetr...)
Affinity DataKi:  0.5nM ΔG°:  -12.6kcal/mole EC50:  2nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18589BDBM18589(6-[(2-chloroethyl)(2,2,2-trifluoroethyl)amino]-4-(...)
Affinity DataKi:  2.60nM ΔG°:  -12.2kcal/mole EC50:  0.5nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18606BDBM18606(6-[bis(2,2,2-trifluoroethyl)amino]-4-chloro-1,2-di...)
Affinity DataKi:  0.5nM EC50:  0.890nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18607BDBM18607(6-[bis(2,2,2-trifluoroethyl)amino]-4-bromo-1,2-dih...)
Affinity DataKi:  0.5nM EC50:  1nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29324BDBM29324(oxazolidin-2-imine, 6g)
Affinity DataKi:  0.700nM ΔG°:  -12.4kcal/mole EC50:  3.70nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18173BDBM18173(4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrro...)
Affinity DataKi:  1.40nM ΔG°:  -11.9kcal/mole EC50:  0.700nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18183BDBM18183(4-[(1S,7R,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1...)
Affinity DataKi:  0.700nM ΔG°:  -12.4kcal/mole EC50:  2.60nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18601BDBM18601(6-[bis(2,2,2-trifluoroethyl)amino]-4-methyl-1,2-di...)
Affinity DataKi:  1.40nM EC50:  0.800nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29318BDBM29318(oxazolidin-2-imine, 6a)
Affinity DataKi:  0.800nM ΔG°:  -12.3kcal/mole EC50:  4.80nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18584BDBM18584(6-[propan-2-yl(2,2,2-trifluoroethyl)amino]-4-(trif...)
Affinity DataKi:  2.90nM ΔG°:  -12.1kcal/mole EC50:  0.900nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18177BDBM18177(4-[(1S,7S,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1...)
Affinity DataKi:  0.900nM ΔG°:  -12.2kcal/mole EC50:  1.80nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18178BDBM18178(4-[(1R,7S,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)...)
Affinity DataKi:  0.900nM ΔG°:  -12.2kcal/mole EC50:  2.5nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18600BDBM18600(6-[bis(2,2,2-trifluoroethyl)amino]-1,2-dihydroquin...)
Affinity DataKi:  24nM IC50: 1nM EC50:  57nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18162BDBM18162(CHEMBL185880 | (1R,6R,7S)-4-(4-nitronaphthalen-1-y...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/mole EC50:  385nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18184BDBM18184(4-[(1R,7R,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/mole EC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18216BDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataKi:  7.10nM EC50:  1.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29322BDBM29322(oxazolidin-2-imine, 6e)
Affinity DataKi:  2.30nM ΔG°:  -11.7kcal/mole EC50:  1.10nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18193BDBM18193(1-ethyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinoli...)
Affinity DataKi:  1.20nM ΔG°:  -12.7kcal/mole EC50:  6.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18582BDBM18582(6-[propyl(2,2,2-trifluoroethyl)amino]-4-(trifluoro...)
Affinity DataKi:  12nM ΔG°:  -11.2kcal/mole EC50:  1.30nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18198BDBM18198(1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H...)
Affinity DataKi:  1.60nM ΔG°:  -12.5kcal/mole EC50:  1.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18522BDBM18522(6-[(2R,5R)-2-methyl-5-[(1R)-2,2,2-trifluoro-1-hydr...)
Affinity DataKi:  1.5nM ΔG°:  -12.5kcal/mole EC50:  7.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18176BDBM18176(JMC522794 Compound 16 | 4-[(1S,7S,7aR)-7-hydroxy-1...)
Affinity DataKi:  1.5nM ΔG°:  -11.9kcal/mole EC50:  5.20nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18165BDBM18165((6R)-6-hydroxy-2-(4-nitronaphthalen-1-yl)-hexahydr...)
Affinity DataKi:  1.5nM ΔG°:  -11.9kcal/mole EC50:  320nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18531BDBM18531(6-(dipropylamino)-4-(trifluoromethyl)-1,2-dihydroq...)
Affinity DataKi:  64nM ΔG°:  -10.2kcal/mole EC50:  1.5nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18168BDBM18168((7R,7aS)-7-hydroxy-2-(4-nitronaphthalen-1-yl)-hexa...)
Affinity DataKi:  2.10nM ΔG°:  -11.7kcal/mole EC50:  1.5nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18169BDBM18169((7S,7aR)-7-hydroxy-2-(4-nitronaphthalen-1-yl)-hexa...)
Affinity DataKi:  1.5nM ΔG°:  -11.9kcal/mole EC50:  281nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18176BDBM18176(JMC522794 Compound 16 | 4-[(1S,7S,7aR)-7-hydroxy-1...)
Affinity DataKi:  1.60nM ΔG°:  -11.9kcal/mole EC50:  5.40nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18180BDBM18180(4-[(1R,7S,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1...)
Affinity DataKi:  1.60nM ΔG°:  -11.9kcal/mole EC50:  7.10nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18590BDBM18590(6-[(2,2-dichloroethyl)(2,2,2-trifluoroethyl)amino]...)
Affinity DataKi:  6nM ΔG°:  -11.7kcal/mole EC50:  1.60nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18164BDBM18164(2-(4-nitronaphthalen-1-yl)-hexahydro-1H-pyrrolo[1,...)
Affinity DataKi:  1.70nM ΔG°:  -11.8kcal/mole EC50:  270nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18585BDBM18585(6-[(2,2-dimethylpropyl)(2,2,2-trifluoroethyl)amino...)
Affinity DataKi:  12nM ΔG°:  -11.2kcal/mole EC50:  1.80nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18211BDBM18211(1-(cyclopropylmethyl)-2-methyl-9-(trifluoromethyl)...)
Affinity DataKi:  4nM EC50:  1.90nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 29326BDBM29326(guanidine derivative, 12)
Affinity DataKi:  1.90nM ΔG°:  -11.8kcal/mole EC50:  44nMpH: 7.6 T: 2°CAssay Description:Binding assays were conducted by incubating test compound at various concentrations with [3H]DHT with human cancer epithelial breast cell lines MDAMB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 18181BDBM18181(4-[(1S,7S,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)...)
Affinity DataKi:  1.90nM ΔG°:  -11.8kcal/mole EC50:  48nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
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