Compile Data Set for Download or QSAR
Report error Found 350 of Enz. Inhib. data with enzyme = 'Aromatase' and Substrate = 'BDBM8592'
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24341BDBM24341(4-{[(4-chloro-3-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 0.180nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24328BDBM24328(4-{[(4-hydroxy-3-iodophenyl)methyl](4H-1,2,4-triaz...)
Affinity DataIC50: 0.330nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24344BDBM24344(4-({[3-hydroxy-4-(trifluoromethyl)phenyl]methyl}(4...)
Affinity DataIC50: 0.400nMAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24342BDBM24342(4-{[(4-bromo-3-hydroxyphenyl)methyl](4H-1,2,4-tria...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 10016BDBM10016(4-{[(4-bromophenyl)methyl](4H-1,2,4-triazol-4-yl)a...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 10016BDBM10016(4-{[(4-bromophenyl)methyl](4H-1,2,4-triazol-4-yl)a...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24332BDBM24332(4-{[(3-chloro-4-hydroxy-5-methoxyphenyl)methyl](4H...)
Affinity DataIC50: 0.510nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24340BDBM24340(4-{[(4-fluoro-3-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24317BDBM24317(4-[(R)-(3-bromo-4-hydroxyphenyl)(1H-1,2,4-triazol-...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24335BDBM24335((5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 0.770nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 10020BDBM10020(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 0.820nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 10020BDBM10020(YM511-based dual aromatase-sulfatase inhibitor (DA...)
Affinity DataIC50: 0.820nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24331BDBM24331(4-({[4-hydroxy-3-(trifluoromethyl)phenyl]methyl}(4...)
Affinity DataIC50: 0.880nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 13061BDBM13061(CHEMBL1444 | 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1...)
Affinity DataIC50: 0.890nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24336BDBM24336((2-chloro-5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 0.920nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24327BDBM24327(4-{[(3-bromo-4-hydroxyphenyl)methyl](4H-1,2,4-tria...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24343BDBM24343(4-{[(3-hydroxy-4-methoxyphenyl)methyl](4H-1,2,4-tr...)
Affinity DataIC50: 1.20nMAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24320BDBM24320((4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24316BDBM24316(4-[(3-bromo-4-hydroxyphenyl)(1H-1,2,4-triazol-1-yl...)
Affinity DataIC50: 1.80nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 10019BDBM10019((2-chloro-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 2.30nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 10019BDBM10019((2-chloro-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 2.30nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9914BDBM9914(3-[(R)-1H-imidazol-1-yl(4-nitrophenyl)methyl]-4H-c...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24326BDBM24326(4-{[(3-chloro-4-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 2.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24339BDBM24339(4-{[(3-hydroxyphenyl)methyl](4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24329BDBM24329(4-{[(4-hydroxy-3-methoxyphenyl)methyl](4H-1,2,4-tr...)
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24323BDBM24323((2-chloro-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-y...)
Affinity DataIC50: 2.90nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24325BDBM24325(4-{[(3-fluoro-4-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Affinity DataIC50: 2.90nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24306BDBM24306({2-bromo-4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9955BDBM9955((8S)-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{1...)
Affinity DataKi:  3.10nM ΔG°:  -12.1kcal/mole IC50: 37nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24307BDBM24307({2-bromo-4-[(R)-(4-cyanophenyl)(1H-1,2,4-triazol-1...)
Affinity DataIC50: 3.20nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9989BDBM9989((2S,6S,15S)-6-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  3.40nM ΔG°:  -12.0kcal/mole IC50: 31nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24318BDBM24318(4-[(S)-(3-bromo-4-hydroxyphenyl)(1H-1,2,4-triazol-...)
Affinity DataIC50: 3.40nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24337BDBM24337((2-bromo-5-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl...)
Affinity DataIC50: 3.90nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 8889BDBM8889(3-(3,4-Dihydronaphthalen-2-yl)pyridine | Dihydrona...)
Affinity DataIC50: 4.07nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9948BDBM9948((8R)-8-ethyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  4.70nM ΔG°:  -11.8kcal/mole IC50: 54nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9951BDBM9951((8R)-2,15-dimethyl-8-pentyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  5nM ΔG°:  -11.8kcal/mole IC50: 54nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9960BDBM9960((8R)-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{1...)
Affinity DataKi:  5.30nM ΔG°:  -11.7kcal/mole IC50: 49nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24315BDBM24315(4-[(3-chloro-4-hydroxyphenyl)(1H-1,2,4-triazol-1-y...)
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9997BDBM9997((2S,15S)-2-(hydroxymethyl)-15-methyltetracyclo[8.7...)
Affinity DataKi:  5.80nM ΔG°:  -11.7kcal/mole IC50: 49nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9994BDBM9994((2R,8R,15S)-8-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  6nM ΔG°:  -11.7kcal/mole IC50: 50nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9968BDBM9968((8R)-8-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,...)
Affinity DataKi:  6nM ΔG°:  -11.7kcal/mole IC50: 50nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9996BDBM9996(CHEMBL421199 | (2R,15S)-2,15-dimethyltetracyclo[8....)
Affinity DataKi:  6.80nM ΔG°:  -11.6kcal/mole IC50: 60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9981BDBM9981(CHEMBL71715 | 2,15-dimethyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  6.80nM IC50: 60nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9949BDBM9949((8R)-2,15-dimethyl-8-propyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  7nM ΔG°:  -11.6kcal/mole IC50: 60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24314BDBM24314(4-[(4-hydroxyphenyl)(1H-1,2,4-triazol-1-yl)methyl]...)
Affinity DataIC50: 7.20nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24333BDBM24333(4-{[(3,5-dichloro-4-hydroxyphenyl)methyl](4H-1,2,4...)
Affinity DataIC50: 7.60nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9953BDBM9953((8R)-8-heptyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  7.80nM ΔG°:  -11.5kcal/mole IC50: 60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 9952BDBM9952((8R)-8-hexyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  8nM ΔG°:  -11.5kcal/mole IC50: 76nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 10007BDBM10007(4-[6-Methoxybenzofuran-2-yl)-1H-1,2,4-triazol-1-yl...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1,2,6,7-3H ]androstenedione / androstenedione during aromatization. Afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

LigandChemical structure of BindingDB Monomer ID 24311BDBM24311(2-bromo-4-[(3-bromo-4-hydroxyphenyl)(1H-1,2,4-tria...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
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