Compile Data Set for Download or QSAR
Report error Found 131 of Enz. Inhib. data with enzyme = 'Aurora kinase A' and Substrate = 'CHOCKtide'
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12103BDBM12103(CHEMBL484007 | 4-tert-butyl-N-[5-(thien-2-ylacetyl...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12983BDBM12983(N-{5-[(2R)-2-hydroxy-2-phenylacetyl]-1H,4H,5H,6H-p...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12982BDBM12982(CHEMBL385266 | N-{5-[(2R)-2-fluoro-2-phenylacetyl]...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12985BDBM12985(CHEMBL402548 | N-{5-[(2R)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12984BDBM12984(CHEMBL427787 | 4-(4-methylpiperazin-1-yl)-N-{5-[(2...)
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12110BDBM12110(5-N-(2,6-diethylphenyl)-3-N-[4-(4-methylpiperazin-...)
Affinity DataIC50: 27nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12110BDBM12110(5-N-(2,6-diethylphenyl)-3-N-[4-(4-methylpiperazin-...)
Affinity DataIC50: 27nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31541BDBM31541(pyrazolo[4,3-h]quinazoline-3-carboxamide, 24)
Affinity DataIC50: 30nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12104BDBM12104(4-tert-butyl-N-[5-(furan-2-carbonyl)-1,4,5,6-tetra...)
Affinity DataIC50: 41nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31532BDBM31532(pyrazolo[4,3-h]quinazoline-3-carboxamide, 1)
Affinity DataIC50: 50nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31542BDBM31542(pyrazolo[4,3-h]quinazoline-3-carboxamide, 25)
Affinity DataIC50: 51nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31539BDBM31539(pyrazolo[4,3-h]quinazoline-3-carboxamide, 22)
Affinity DataIC50: 53nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12107BDBM12107(CHEMBL516110 | 5-Amido-pyrrolopyrazole 3 | 4-(4-me...)
Affinity DataIC50: 65nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12107BDBM12107(CHEMBL516110 | 5-Amido-pyrrolopyrazole 3 | 4-(4-me...)
Affinity DataIC50: 65nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25680BDBM25680(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Affinity DataIC50: 79nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25683BDBM25683(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Affinity DataIC50: 97nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12106BDBM12106(3-(4-tert-Butyl-benzoylamino)-4,6-dihydro-1H-pyrro...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12105BDBM12105(CHEMBL192575 | 4-tert-butyl-N-(5-phenylacetyl-1,4,...)
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12109BDBM12109(CHEMBL190252 | 4-(4-methylpiperazin-1-yl)-N-[5-(2-...)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25681BDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50: 140nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12109BDBM12109(CHEMBL190252 | 4-(4-methylpiperazin-1-yl)-N-[5-(2-...)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12091BDBM12091(N-[5-(2-methylpropanoyl)-1H,4H,5H,6H-pyrrolo[3,4-c...)
Affinity DataIC50: 160nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12108BDBM12108(N-[5-(furan-2-ylcarbonyl)-1H,4H,5H,6H-pyrrolo[3,4-...)
Affinity DataIC50: 160nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31540BDBM31540(pyrazolo[4,3-h]quinazoline-3-carboxamide, 23)
Affinity DataIC50: 175nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31534BDBM31534(pyrazolo[4,3-h]quinazoline-3-carboxamide, 17)
Affinity DataIC50: 213nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31533BDBM31533(pyrazolo[4,3-h]quinazoline-3-carboxamide, 16)
Affinity DataIC50: 312nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25684BDBM25684(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(1-methoxypr...)
Affinity DataIC50: 330nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12987BDBM12987(CHEMBL384575 | N-{5-[(2S)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 354nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25678BDBM25678(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}aceta...)
Affinity DataIC50: 360nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31535BDBM31535(pyrazolo[4,3-h]quinazoline-3-carboxamide, 18)
Affinity DataIC50: 364nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31538BDBM31538(pyrazolo[4,3-h]quinazoline-3-carboxamide, 21)
Affinity DataIC50: 374nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12092BDBM12092(3-N-(2H-1,3-benzodioxole-5-)-5-N-(propan-2-yl)-1H,...)
Affinity DataIC50: 390nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25658BDBM25658(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50: 400nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12090BDBM12090(4-methyl-N-[5-(quinolin-8-ylcarbonyl)-1H,4H,5H,6H-...)
Affinity DataIC50: 440nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25697BDBM25697(3-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Affinity DataIC50: 440nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12986BDBM12986(CHEMBL217748 | 4-(4-methylpiperazin-1-yl)-N-{5-[(2...)
Affinity DataIC50: 452nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25660BDBM25660(N-(4-fluorophenyl)-5-iodo-1,3-thiazol-2-amine | am...)
Affinity DataIC50: 500nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25694BDBM25694(5-bromo-N-[3-(methylsulfanyl)phenyl]-1,3-thiazol-2...)
Affinity DataIC50: 500nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25669BDBM25669(4-[(5-bromo-1,3-thiazol-2-yl)amino]phenol | aminot...)
Affinity DataIC50: 510nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31553BDBM31553(pyrazolo[4,3-h]quinazoline-3-carboxamide, 36)
Affinity DataIC50: 535nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31544BDBM31544(pyrazolo[4,3-h]quinazoline-3-carboxamide, 27)
Affinity DataIC50: 582nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25676BDBM25676(1-N-(5-bromo-1,3-thiazol-2-yl)benzene-1,4-diamine ...)
Affinity DataIC50: 600nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31548BDBM31548(pyrazolo[4,3-h]quinazoline-3-carboxamide, 31)
Affinity DataIC50: 625nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31554BDBM31554(pyrazolo[4,3-h]quinazoline-3-carboxamide, 37)
Affinity DataIC50: 638nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31547BDBM31547(pyrazolo[4,3-h]quinazoline-3-carboxamide, 30)
Affinity DataIC50: 649nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 12086BDBM12086(N-{5-acetyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl...)
Affinity DataIC50: 660nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25699BDBM25699(3-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50: 740nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 31555BDBM31555(pyrazolo[4,3-h]quinazoline-3-carboxamide, 38)
Affinity DataIC50: 855nMT: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25721BDBM25721(4-({6-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-3-y...)
Affinity DataIC50: 880nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandChemical structure of BindingDB Monomer ID 25673BDBM25673(5-bromo-N-[4-(pyridin-4-yloxy)phenyl]-1,3-thiazol-...)
Affinity DataIC50: 900nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
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