Compile Data Set for Download or QSAR
Report error Found 37 of Enz. Inhib. data with enzyme = 'Aurora kinase A' and Substrate = 'Histone H3'
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14192BDBM14192(3-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}a...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14208BDBM14208(3-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14209BDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24722BDBM24722(7,7,16-trimethyl-5,11,14,15-tetraazapentacyclo[10....)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14201BDBM14201(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-phenyl-7H-p...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24721BDBM24721(5-ethyl-7,7,16-trimethyl-5,11,14,15-tetraazapentac...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14207BDBM14207(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-2-...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14203BDBM14203(7-(3-methoxyphenyl)-N-[3-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14191BDBM14191(N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14197BDBM14197(7-(3-methanesulfonylphenyl)-N-[4-(4-methylpiperazi...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14200BDBM14200(7-(3-methanesulfonylphenyl)-N-[3-(4-methylpiperazi...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14205BDBM14205(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14199BDBM14199(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14193BDBM14193(4-[4-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-y...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14202BDBM14202(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14196BDBM14196(N-[4-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14195BDBM14195(7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50: 18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14198BDBM14198(7-(2,3-dihydro-1H-inden-2-yl)-N-[4-(4-methylpipera...)
Affinity DataIC50: 18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14204BDBM14204(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-[3-(propan-...)
Affinity DataIC50: 29nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14194BDBM14194(7-{bicyclo[2.2.1]heptan-2-yl}-N-[4-(4-methylpipera...)
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14210BDBM14210(N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quin...)
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24720BDBM24720(5-methyl-3,4,17-triazatetracyclo[8.7.0.0^{2,6}.0^{...)
Affinity DataIC50: 42nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14189BDBM14189(7-cyclohexyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-...)
Affinity DataIC50: 47nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14190BDBM14190(7-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-7H-pyrro...)
Affinity DataIC50: 49nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24714BDBM24714(5-methyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{...)
Affinity DataIC50: 51nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24712BDBM24712(5-ethyl-7,7-dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-...)
Affinity DataIC50: 69nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24723BDBM24723(5,5,16-trimethyl-7,11,14,15-tetraazapentacyclo[10....)
Affinity DataIC50: 72nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24715BDBM24715(5-cyclopropyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6...)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24711BDBM24711(7,7-dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-1H,5H,6H...)
Affinity DataIC50: 180nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24713BDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24717BDBM24717(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50: 340nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14206BDBM14206(N-cyclopentyl-3-(2-{[3-(4-methylpiperazin-1-yl)phe...)
Affinity DataIC50: 820nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24719BDBM24719(13-methyl-8,11,12-triazatetracyclo[7.6.0.0^{2,7}.0...)
Affinity DataIC50: 870nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24718BDBM24718(2-(5-Methyl-1H-pyrazol-3-yl)-1H-indole | pyrazole-...)
Affinity DataIC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Genentech

LigandChemical structure of BindingDB Monomer ID 24716BDBM24716(ethyl 3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,...)
Affinity DataIC50: 5.70E+3nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed