Compile Data Set for Download or QSAR
Report error Found 16 of Enz. Inhib. data with enzyme = 'Beta-secretase 1' and Substrate = 'BACE-1 Peptide Substrate'
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15786(3-N-{[2-(benzyloxy)-5-(1H-indol-6-yl)phenyl]methyl...)
Affinity DataIC50: 690nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15787(3-N-{[5-(1H-indol-6-yl)-2-(pyridin-2-ylmethoxy)phe...)
Affinity DataIC50: 4.20E+3nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15785(3-N-{[3-(1H-indol-6-yl)phenyl]methyl}pyridine-2,3-...)
Affinity DataIC50: 9.10E+3nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15784(3-N-{[3-(5-propoxypyridin-3-yl)phenyl]methyl}pyrid...)
Affinity DataIC50: 2.40E+4nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15780(6-{2-[3-(3-methoxyphenyl)phenyl]ethyl}pyridin-2-am...)
Affinity DataIC50: 2.50E+4nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15783(3-N-{[3-(5-methoxypyridin-3-yl)phenyl]methyl}pyrid...)
Affinity DataIC50: 4.00E+4nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15779(6-[2-(1H-indol-6-yl)ethyl]pyridin-2-amine | 6-Subs...)
Affinity DataIC50: 9.40E+4nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15782(3-N-{[3-(pyridin-3-yl)phenyl]methyl}pyridine-2,3-d...)
Affinity DataIC50: 1.00E+5nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15781(3-N-benzylpyridine-2,3-diamine | fragment 3 (J. me...)
Affinity DataIC50: 3.10E+5nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15781(3-N-benzylpyridine-2,3-diamine | fragment 3 (J. me...)
Affinity DataIC50: 3.10E+5nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15789((2S)-1-(2,5-dimethylphenoxy)-3-(morpholin-4-yl)pro...)
Affinity DataIC50: 1.00E+6nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM14322(CHEMBL61236 | 2-aminoquinoline | fragment 2 (J. me...)
Affinity DataIC50: 2.00E+6nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15778(6-(2-phenylethyl)pyridin-2-amine | 6-Substituted 2...)
Affinity DataIC50: 2.00E+6nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM14320(CHEMBL62083 | 1-amino-isoquinoline | fragment 1 (J...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM14322(CHEMBL61236 | 2-aminoquinoline | fragment 2 (J. me...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15788(4-[(4-fluorophenyl)methyl]piperidine | CHEMBL12043...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)