Compile Data Set for Download or QSAR
Report error Found 30 of Enz. Inhib. data with enzyme = 'Beta-secretase 1' and Substrate = 'MBPAPPC125'
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16770((1R,3S,5S)-5-[(3S,4S)-N-[(1S)-1-carbamoyl-2-methyl...)
Affinity DataIC50: 1nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16250(CHEMBL290001 | tert-butyl N-[(1S)-1-{[(1S)-1-{[(1R...)
Affinity DataIC50: 3nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15797(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[...)
Affinity DataIC50: 5nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16771((1R,3S,5S)-5-[(3S,4S)-N-[(1S)-1-carbamoyl-2-methyl...)
Affinity DataIC50: 20nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50: 20nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16765(4-{[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(dipro...)
Affinity DataIC50: 26nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15790(CHEMBL42908 | Hydroxyethylene-Based Peptidomimetic...)
Affinity DataIC50: 30nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16798((4S)-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}-4...)
Affinity DataIC50: 30nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15790(CHEMBL42908 | Hydroxyethylene-Based Peptidomimetic...)
Affinity DataIC50: 30nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16766(4-{[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(dipro...)
Affinity DataIC50: 45nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16761(trans-4-({[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-({[...)
Affinity DataIC50: 50nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15794(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[...)
Affinity DataIC50: 70nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15792(N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({(1...)
Affinity DataIC50: 130nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15796((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(ben...)
Affinity DataIC50: 130nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16760(8-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50: 200nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15795(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-({...)
Affinity DataIC50: 200nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16759(6-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50: 240nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16757(4-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50: 310nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16768(4-{[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(dipro...)
Affinity DataIC50: 310nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16767(4-{[(4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(dipropyl...)
Affinity DataIC50: 400nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16758(5-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50: 400nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16762(methyl 8-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-...)
Affinity DataIC50: 410nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15793(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[...)
Affinity DataIC50: 500nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16764(3-N-[(2S,3S,5R)-5-(benzylcarbamoyl)-1-(3,5-difluor...)
Affinity DataIC50: 1.40E+3nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16756(3-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50: 2.80E+3nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16799((4S)-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}-4...)
Affinity DataIC50: 4.00E+3nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16763(CHEMBL295109 | 3-N-[(2S,3S,5R)-1-(3,5-difluorophen...)
Affinity DataIC50: 6.60E+3nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16800((4S)-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}-4...)
Affinity DataIC50: 7.50E+3nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16769(4-{[(2R,4S,5S)-2-benzyl-6-(3,5-difluorophenyl)-5-{...)
Affinity DataIC50: 2.70E+4nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15791(N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({(1...)
Affinity DataIC50: 6.80E+4nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed