Compile Data Set for Download or QSAR
Report error Found 12 of Enz. Inhib. data with enzyme = 'Beta-secretase 2' and Substrate = 'Fluorogenic Substrate'
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16250(CHEMBL290001 | tert-butyl N-[(1S)-1-{[(1S)-1-{[(1R...)
Affinity DataKi:  1.20nM ΔG°:  -12.7kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16259(Isophthalamide Derivative 5d | 1-N-[(1R,3S,4S)-3-h...)
Affinity DataKi:  31nM ΔG°:  -10.6kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16252((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  161nM ΔG°:  -9.63kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16034(N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxy...)
Affinity DataKi:  240nM ΔG°:  -9.39kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16256(1-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-...)
Affinity DataKi:  340nM ΔG°:  -9.17kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  356nM ΔG°:  -9.14kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16261(1-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-...)
Affinity DataKi:  397nM ΔG°:  -9.08kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16262(1-N-[1-(2,5-dimethyl-1,3-oxazol-4-yl)ethyl]-3-N-[(...)
Affinity DataKi:  408nM ΔG°:  -9.06kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16254(N2-[(2R,4S,5S)-5-{[N-{[(2,5-dimethyl-1,3-oxazol-4-...)
Affinity DataKi:  458nM ΔG°:  -8.99kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16258(1-N-benzyl-3-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-...)
Affinity DataKi:  523nM ΔG°:  -8.91kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16257(1-N-[(2,5-dimethyl-1,3-oxazol-4-yl)methyl]-3-N-[(1...)
Affinity DataKi:  556nM ΔG°:  -8.87kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16251((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1S)-1-{[(...)
Affinity DataKi:  811nM ΔG°:  -8.64kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed