Compile Data Set for Download or QSAR
Report error Found 54 of Enz. Inhib. data with enzyme = 'Bile acid receptor' and Substrate = 'BDBM10852'
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28533(ethyl 3-[(4-fluorophenyl)carbonyl]-1-methyl-1H,2H,...)
Affinity DataEC50:  57nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21725((1S,2R,10R,11S,14Z,15S)-14-ethylidene-2,15-dimethy...)
Affinity DataEC50:  1.20E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  65nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30329(Naphthoic acid-based analog, 1b)
Affinity DataEC50:  68nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30330(Naphthoic acid-based analog, 1c)
Affinity DataEC50:  45nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30331(Naphthoic acid-based analog, 1d)
Affinity DataEC50:  500nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30332(Naphthoic acid-based analog, 1e)
Affinity DataEC50:  3.30E+3nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28529(ethyl 3-[(4-fluorophenyl)carbonyl]-1H,2H,3H,6H-aze...)
Affinity DataEC50:  600nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28530(propan-2-yl 3-[(4-fluorophenyl)carbonyl]-1H,2H,3H,...)
Affinity DataEC50:  500nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28531(propyl 3-[(4-fluorophenyl)carbonyl]-1H,2H,3H,6H-az...)
Affinity DataEC50:  500nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28532(butyl 3-[(4-fluorophenyl)carbonyl]-1H,2H,3H,6H-aze...)
Affinity DataEC50:  1.10E+3nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  361nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28534(ethyl 3-[(4-chlorophenyl)carbonyl]-1-methyl-1H,2H,...)
Affinity DataEC50:  73nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28535(ethyl 3-[(4-methoxyphenyl)carbonyl]-1-methyl-1H,2H...)
Affinity DataEC50:  60nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28536(ethyl 3-[(3,4-difluorophenyl)carbonyl]-1-methyl-1H...)
Affinity DataEC50:  32nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28537(ethyl 3-[(4-fluorophenyl)carbonyl]-1,1-dimethyl-1H...)
Affinity DataEC50:  22nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28538(ethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethy...)
Affinity DataEC50:  12nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28539(ethyl 3-[(4-chlorophenyl)carbonyl]-1,1-dimethyl-1H...)
Affinity DataEC50:  25nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28540(ethyl 3-[(4-methoxyphenyl)carbonyl]-1,1-dimethyl-1...)
Affinity DataEC50:  29nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28541(propan-2-yl 3-[(4-fluorophenyl)carbonyl]-1,1-dimet...)
Affinity DataEC50:  8nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28542(propan-2-yl 3-[(3,4-difluorophenyl)carbonyl]-1,1-d...)
Affinity DataEC50:  4nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  2.70E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  1.30E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21677((2R,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  1.05E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21678((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-5,9...)
Affinity DataEC50:  1.16E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21679((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-e...)
Affinity DataEC50:  1.18E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21710(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  9.00E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21711(N,N-dibenzyl-3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlor...)
Affinity DataEC50:  3.51E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21712(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21713(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  3.10E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21714(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  2.10E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21715(3-[benzyl(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  2.50E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21716(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  840nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21717(3-[(E)-2-(4-{[5-tert-butyl-3-(2,6-dichlorophenyl)-...)
Affinity DataEC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21718(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-ph...)
Affinity DataEC50:  1.58E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21719(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(n...)
Affinity DataEC50:  2.22E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21720(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(4...)
Affinity DataEC50:  3.39E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21721(3-[(4-{[5-tert-butyl-3-(2,6-dichlorophenyl)-1,2-ox...)
Affinity DataEC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21722(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(naphtha...)
Affinity DataEC50:  4.00E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21723(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(4-pheny...)
Affinity DataEC50:  3.70E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  70nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30337(3-aryl isoxazole analog, 7b)
Affinity DataIC50: 45nM EC50:  102nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataIC50: 64nM EC50:  900nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30336(3-aryl isoxazole analog, 7a)
Affinity DataIC50: 94nM EC50:  900nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30334(3-aryl isoxazole analog, 6c)
Affinity DataIC50: 170nM EC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30333(3-aryl isoxazole analog, 6b)
Affinity DataIC50: 250nM EC50:  1.00E+4nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30335(CHEMBL469135 | 3-aryl isoxazole analog, 6d)
Affinity DataIC50: 690nM EC50:  9.00E+3nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30342(3-aryl isoxazole analog, 7g)
Affinity DataIC50: 750nM EC50:  2.00E+3nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM30341(3-aryl isoxazole analog, 7f)
Affinity DataIC50: 880nM EC50:  4.00E+3nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
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