Compile Data Set for Download or QSAR
Report error Found 115 of Enz. Inhib. data with enzyme = 'Caspase-1' and Substrate = 'Caspase-1 Fluorogenic Substrate'
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10355(CHEMBL37630 | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataIC50: 8.10nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 190nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10556((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-hydroxy-2-(5-...)
Affinity DataIC50: 675nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10660((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(3,5-dibromophe...)
Affinity DataIC50: 860nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10535((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-(5-bromo...)
Affinity DataIC50: 1.03E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10551((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-bromo-2-me...)
Affinity DataIC50: 1.54E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10674((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50: 1.60E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10675((3S)-3-[(2S)-2-[(2S)-2-[(3S)-3-formamido-3-(phenyl...)
Affinity DataIC50: 1.65E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10664((3S)-5-[(cyclohexylmethyl)sulfanyl]-3-[(2S)-2-[1-(...)
Affinity DataIC50: 1.80E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10653(Compound 3 | (3S)-5-{[(2-chloro-6-fluorophenyl)met...)
Affinity DataIC50: 1.80E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10555((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{2-hydroxy-2-[2-...)
Affinity DataIC50: 2.46E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10661((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(5-fluoro-1H-in...)
Affinity DataIC50: 2.60E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10662((3S)-3-[(2S)-2-[1-(2,5-dimethoxyphenyl)acetamido]-...)
Affinity DataIC50: 2.60E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10540((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-hydroxy-...)
Affinity DataIC50: 3.02E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10527(valine aspartyl ketone 29 | BROMOMETHOXYPHENYL INH...)
Affinity DataIC50: 3.04E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10527(valine aspartyl ketone 29 | BROMOMETHOXYPHENYL INH...)
Affinity DataIC50: 3.05E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10527(valine aspartyl ketone 29 | BROMOMETHOXYPHENYL INH...)
Affinity DataIC50: 3.10E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10671((3S)-3-[(2S)-2-{1-[5-(carboxymethoxy)-2-ethoxyphen...)
Affinity DataIC50: 3.80E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10538((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-hydroxy-...)
Affinity DataIC50: 4.06E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10537((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-hydroxy-...)
Affinity DataIC50: 4.16E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10670((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50: 4.20E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10549((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(2,5-dimethox...)
Affinity DataIC50: 4.49E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10553((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-acetyl-2-m...)
Affinity DataIC50: 4.85E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10334((S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrroli...)
Affinity DataIC50: 5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10348(5-{[(2S)-2-[(pyridin-3-yloxy)methyl]pyrrolidine-1-...)
Affinity DataIC50: 5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10354(5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50: 5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10663((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50: 5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10554((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{1-[2-methoxy-5-...)
Affinity DataIC50: 5.45E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10530((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo...)
Affinity DataIC50: 5.81E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10552((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-acetyl-2-m...)
Affinity DataIC50: 5.90E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10548(valine aspartyl ketone analog 1 | (3S)-5-(benzylsu...)
Affinity DataIC50: 6.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10552((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-acetyl-2-m...)
Affinity DataIC50: 6.19E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10669((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50: 6.50E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10533((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo...)
Affinity DataIC50: 6.51E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10548(valine aspartyl ketone analog 1 | (3S)-5-(benzylsu...)
Affinity DataIC50: 7.07E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10546((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(1-hydroxycyclo...)
Affinity DataIC50: 9.59E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10318(5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10323(JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10330((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrroli...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10338(5-{[(2S)-2-(phenoxymethyl)azetidine-1-]sulfonyl}-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10339(1-methyl-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]su...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10340(1-benzyl-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]su...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10343((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10347((S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10349(1-methyl-5-{[(2S)-2-[(pyridin-3-yloxy)methyl]pyrro...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10350(1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10351(1-[(4-methoxyphenyl)methyl]-5-{[(2S)-2-[(pyridin-3...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10353(1-[(4-fluorophenyl)methyl]-5-{[(2S)-2-[(pyridin-3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10528((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
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