Compile Data Set for Download or QSAR
Report error Found 188 of Enz. Inhib. data with enzyme = 'Caspase-3' and Substrate = 'Caspase Fluorogenic Substrate'
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10652((3S)-3-[(2S)-2-[(4S)-4-[(3S)-3-acetamido-3-formami...)
Affinity DataIC50: 0.771nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10675((3S)-3-[(2S)-2-[(2S)-2-[(3S)-3-formamido-3-(phenyl...)
Affinity DataIC50: 1.80nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10654((3S)-5-(benzylsulfanyl)-3-{[(2S,11S)-11-[(3S)-3-ac...)
Affinity DataIC50: 3nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10324(tert-butyl 2-(2,3-dioxo-5-{[(2S)-2-(phenoxymethyl)...)
Affinity DataIC50: 3.10nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 3.10nMpH: 7.5 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 3.80nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10403(7-methyl-12-(morpholine-4-sulfonyl)-4-(1,3,5-trime...)
Affinity DataIC50: 4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10326((S)-1-(4-Pyridinylmethyl)-5-{1-[2-(phenoxymethyl)p...)
Affinity DataIC50: 4.20nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10352(1-{[4-(methylsulfanyl)phenyl]methyl}-5-{[(2S)-2-[(...)
Affinity DataIC50: 4.40nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10321((S)-1-Allyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]su...)
Affinity DataIC50: 4.60nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10551((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-bromo-2-me...)
Affinity DataIC50: 5nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10671((3S)-3-[(2S)-2-{1-[5-(carboxymethoxy)-2-ethoxyphen...)
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10674((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10322(1-(cyclohexylmethyl)-5-{[(2S)-2-(phenoxymethyl)pyr...)
Affinity DataIC50: 5.20nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10350(1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine...)
Affinity DataIC50: 5.20nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10347((S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 5.80nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10653(Compound 3 | (3S)-5-{[(2-chloro-6-fluorophenyl)met...)
Affinity DataIC50: 7.95nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10653(Compound 3 | (3S)-5-{[(2-chloro-6-fluorophenyl)met...)
Affinity DataIC50: 8nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataIC50: 8.40nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10353(1-[(4-fluorophenyl)methyl]-5-{[(2S)-2-[(pyridin-3-...)
Affinity DataIC50: 8.40nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10343((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50: 8.80nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10554((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{1-[2-methoxy-5-...)
Affinity DataIC50: 9nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10337(1-[(6-fluoropyridin-2-yl)methyl]-5-{[(2S)-2-(pheno...)
Affinity DataIC50: 9.10nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10656(Compound 6 | (3S)-3-[2-(5-tert-butyl-3-{[(4-methyl...)
Affinity DataIC50: 9.17nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50: 9.40nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10340(1-benzyl-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]su...)
Affinity DataIC50: 9.70nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10552((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-acetyl-2-m...)
Affinity DataIC50: 10nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10335((S)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxyme...)
Affinity DataIC50: 10.3nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10345((S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymet...)
Affinity DataIC50: 10.9nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10342(1-{[4-(methylsulfanyl)phenyl]methyl}-5-{[(2S)-2-(p...)
Affinity DataIC50: 11.3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10333(Acetic Acid (S)-4-[2,3-Dioxo-5-(2-phenoxymethyl-py...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10555((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{2-hydroxy-2-[2-...)
Affinity DataIC50: 12nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10331((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolid...)
Affinity DataIC50: 12.1nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10323(JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-be...)
Affinity DataIC50: 12.2nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10332(1-{[4-(methylsulfanyl)phenyl]methyl}-5-{[(2S)-2-(p...)
Affinity DataIC50: 12.4nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10552((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-acetyl-2-m...)
Affinity DataIC50: 13nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10334((S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrroli...)
Affinity DataIC50: 13.5nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10330((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrroli...)
Affinity DataIC50: 14.5nMpH: 7.4 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10392(7-methyl-4-(2-methylphenyl)-12-(morpholine-4-sulfo...)
Affinity DataIC50: 15nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10385(methyl 2-[7-methyl-12-(morpholine-4-sulfonyl)-3,5-...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10397(7-methyl-3,5-dioxo-4-(1,3,5-trimethyl-1H-pyrazol-4...)
Affinity DataIC50: 16nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10553((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-acetyl-2-m...)
Affinity DataIC50: 16nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10556((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-hydroxy-2-(5-...)
Affinity DataIC50: 16nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10535((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-(5-bromo...)
Affinity DataIC50: 17nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10527(valine aspartyl ketone 29 | BROMOMETHOXYPHENYL INH...)
Affinity DataIC50: 17.7nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10527(valine aspartyl ketone 29 | BROMOMETHOXYPHENYL INH...)
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10527(valine aspartyl ketone 29 | BROMOMETHOXYPHENYL INH...)
Affinity DataIC50: 18nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10399(2-hydroxy-N-[7-methyl-3,5-dioxo-4-(1,3,5-trimethyl...)
Affinity DataIC50: 20nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10354(5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50: 20.4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandPNGBDBM10400(N-(2-methoxyethyl)-7-methyl-3,5-dioxo-4-(1,3,5-tri...)
Affinity DataIC50: 21nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2006
Entry Details Article
PubMed
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