Compile Data Set for Download or QSAR
Report error Found 85 of Enz. Inhib. data with enzyme = 'Caspase-3' and Substrate = 'Caspase-3 Fluorogenic Substrate'
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10246BDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataKi:  0.230nM ΔG°:  -13.1kcal/molepH: 7.5 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 226BDBM226(Thiophene Scaffold 66b | (S)-5-({5-[1-Carboxymethy...)
Affinity DataKi:  20nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 280BDBM280(5-{[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  20nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 223BDBM223(5-{[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methyl...)
Affinity DataKi:  20nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 263BDBM263(5-{[(5-{[(2S)-1-carboxy-3-oxo-4-[(pyridin-3-ylmeth...)
Affinity DataKi:  20nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 222BDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  30nM ΔG°:  -10.3kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 264BDBM264((S)-5-({5-[1-Carboxymethyl-2-oxo-3-(pyridin-4-ylme...)
Affinity DataKi:  30nM ΔG°:  -10.3kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 224BDBM224((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  30nM ΔG°:  -10.3kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 227BDBM227(Heterocyclic deriv. 69b | (S)-5-({5-[1-Carboxymeth...)
Affinity DataKi:  40nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 221BDBM221(Pyridine Scaffold 4 | 5-{[(5-{[(2S)-1-carboxy-3-ox...)
Affinity DataKi:  50nM ΔG°:  -9.95kcal/molepH: 7.4 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 232BDBM232(Heterocyclic deriv. 65b | 5-{[(3-{[(2S)-1-carboxy-...)
Affinity DataKi:  60nM ΔG°:  -9.85kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10193BDBM10193(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  70nM ΔG°:  -9.66kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 230BDBM230(Heterocyclic deriv. 64a | 5-{[(5-{[(2S)-1-carboxy-...)
Affinity DataKi:  70nM ΔG°:  -9.75kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10198BDBM10198(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  70nM ΔG°:  -9.75kcal/moleT: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 219BDBM219(5-({[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methy...)
Affinity DataKi:  90nM ΔG°:  -9.61kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 229BDBM229(5-{[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methyl...)
Affinity DataKi:  90nM ΔG°:  -9.61kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10188BDBM10188(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -9.45kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10205BDBM10205((3S)-4-oxo-3-(6-{[3-(5-oxo-4,5-dihydro-1,2,4-oxadi...)
Affinity DataKi:  100nM ΔG°:  -9.54kcal/moleT: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10189BDBM10189(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -9.45kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10196BDBM10196(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -9.45kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10199BDBM10199(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  100nM ΔG°:  -9.54kcal/moleT: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 225BDBM225(Thiophene Scaffold 66a | (S)-5-5-(1-Carboxymethyl-...)
Affinity DataKi:  120nM ΔG°:  -9.43kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 256BDBM256(5-({N-[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)met...)
Affinity DataKi:  140nM ΔG°:  -9.34kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 253BDBM253(5-{[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methyl...)
Affinity DataKi:  140nM ΔG°:  -9.34kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 269BDBM269((S)-3-{[5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-p...)
Affinity DataKi:  160nM ΔG°:  -9.26kcal/molepH: 7.4 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 231BDBM231(Heterocyclic deriv. 65a | 5-{[(3-{[(2S)-1-carboxy-...)
Affinity DataKi:  160nM ΔG°:  -9.26kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 277BDBM277(5-{[(5-{[(2S)-1-carboxy-4-(methylsulfanyl)-3-oxobu...)
Affinity DataKi:  190nM ΔG°:  -9.16kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 220BDBM220(5-{[(4-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  200nM ΔG°:  -9.13kcal/molepH: 7.4 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10190BDBM10190(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  200nM ΔG°:  -9.04kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10191BDBM10191(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  200nM ΔG°:  -9.04kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10192BDBM10192(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  200nM ΔG°:  -9.04kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10194BDBM10194(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  200nM ΔG°:  -9.04kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10195BDBM10195(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  200nM ΔG°:  -9.04kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 259BDBM259(5-{[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methyl...)
Affinity DataKi:  210nM ΔG°:  -9.10kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 265BDBM265(Thiophene Scaffold 73 | 5-{[(5-{[(2S)-1-carboxy-3-...)
Affinity DataKi:  240nM ΔG°:  -9.02kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 257BDBM257((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  270nM ΔG°:  -8.95kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 260BDBM260(5-{[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  290nM ΔG°:  -8.91kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 248BDBM248(5-({5-[1-Carboxymethyl-2-(7-methyl-benzoxazol-2-yl...)
Affinity DataKi:  290nM ΔG°:  -8.91kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10209BDBM10209(5-[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methyl]...)
Affinity DataKi:  300nM ΔG°:  -8.89kcal/moleT: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10213BDBM10213(5-({[5-(1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbam...)
Affinity DataKi:  300nM ΔG°:  -8.89kcal/moleT: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10214BDBM10214(5-({[5-({[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoy...)
Affinity DataKi:  300nM ΔG°:  -8.89kcal/moleT: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 252BDBM252((3S)-5-{[(2-chlorophenyl)methyl]sulfanyl}-4-oxo-3-...)
Affinity DataKi:  310nM ΔG°:  -8.87kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 247BDBM247(Thiophene Scaffold 41b | 5-[(5-{1-Carboxymethyl-2-...)
Affinity DataKi:  380nM ΔG°:  -8.75kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 10207BDBM10207(5-[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}...)
Affinity DataKi:  400nM ΔG°:  -8.72kcal/moleT: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 251BDBM251(Thiophene Scaffold 76 | (S)-3-({5-[1-Carboxymethyl...)
Affinity DataKi:  400nM ΔG°:  -8.72kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 276BDBM276(Pyridine Scaffold 57 | (S)-4-Oxo-3-[(6-{[3-(5-oxo-...)
Affinity DataKi:  400nM ΔG°:  -8.72kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 279BDBM279(6-[(4-Hydroxy-3-methyl-benzenesulfonylamino)methyl...)
Affinity DataKi:  410nM ΔG°:  -8.71kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 275BDBM275((S)-4-Oxo-3-[(6-{[3-(1H-tetrazol-5-yl)benzenesulfo...)
Affinity DataKi:  440nM ΔG°:  -8.67kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 278BDBM278(5-{[(5-{[(2S)-3-carboxy-1-[5-(2,6-dichlorophenyl)-...)
Affinity DataKi:  450nM ΔG°:  -8.65kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
TargetCaspase-3(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 274BDBM274((3S)-3-[(6-{[3-(ethanesulfonyl)benzene]sulfonamido...)
Affinity DataKi:  470nM ΔG°:  -8.63kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2003
Entry Details Article
PubMed
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