Compile Data Set for Download or QSAR
Report error Found 73 of Enz. Inhib. data with enzyme = 'Caspase-3' and Substrate = 'Caspase-3 Substrate'
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 2.20nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10323(JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-be...)
Affinity DataIC50: 14.5nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 21nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10284(4-oxo-4-(piperidin-1-yl)-N-(1,3,4-trioxo-1,2,3,4-t...)
Affinity DataIC50: 25nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: 27.8nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10264(2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50: 40nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10283(N-(prop-2-en-1-yl)-N'-(1,3,4-trioxo-1,2,3,4-tetrah...)
Affinity DataIC50: 44nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10261(N-(1,3,4-Trioxo-1,2,3,4-tetrahydro-isoquinolin-5-y...)
Affinity DataIC50: 53nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10270(4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50: 54nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10291(N-(3-ethoxyphenyl)-N'-(1,3,4-trioxo-1,2,3,4-tetrah...)
Affinity DataIC50: 55nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10282(N-propyl-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50: 59nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10274(2-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50: 62nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10276(Methyl 3-(1, 2, 3, 4-tetrahydro-1, 3, 4-trioxoisoq...)
Affinity DataIC50: 66nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10280(N-(1,3,4-Trioxo-1,2,3,4-tetrahydro-isoquinolin-6-y...)
Affinity DataIC50: 68nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10285(N-benzyl-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50: 70nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10292(N-(3-Propoxy-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetra...)
Affinity DataIC50: 71nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10271(2-chloro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquin...)
Affinity DataIC50: 78nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10281(4-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-y...)
Affinity DataIC50: 79nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10278(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)
Affinity DataIC50: 83nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10279(2-chloro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquin...)
Affinity DataIC50: 92nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10255(N-(1,2,3,4-Tetrahydro-1,3,4-trioxoisoquinolin-5-yl...)
Affinity DataIC50: 96nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10260(N-(1,2,3,4-Tetrahydro-1,3,4-trioxoisoquinolin-5-yl...)
Affinity DataIC50: 99nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10269(2-methoxy-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50: 103nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10262(methyl 3-nitro-5-[(1,3,4-trioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50: 104nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10254(N-(1,3,4-Trioxo-1,2,3,4-tetrahydro-isoquinolin-5-y...)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10287(N-(2-Methoxy-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetra...)
Affinity DataIC50: 113nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM29581(isatin sulfonamide, 16a)
Affinity DataIC50: 114nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10275(N-(1,2,3,4-Tetrahydro-1,3,4-trioxoisoquinolin-6-yl...)
Affinity DataIC50: 118nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10256(4-nitro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquino...)
Affinity DataIC50: 124nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10267(2-phenyl-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquin...)
Affinity DataIC50: 139nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10277(4-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)
Affinity DataIC50: 140nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10290(N-(4-Fluoro-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetrah...)
Affinity DataIC50: 145nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10289(N-(3-Methoxy-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetra...)
Affinity DataIC50: 148nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10247(1,2,3,4-tetrahydroisoquinoline-1,3,4-trione | Isoq...)
Affinity DataIC50: 149nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10257(2-chloro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquin...)
Affinity DataIC50: 150nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10288(N-(4-Methoxy-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetra...)
Affinity DataIC50: 158nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10272(N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl...)
Affinity DataIC50: 164nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10268(N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl...)
Affinity DataIC50: 176nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10258(N-(1,3,4-Trioxo-1,2,3,4-tetrahydro-isoquinolin-5-y...)
Affinity DataIC50: 191nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10259(N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl...)
Affinity DataIC50: 193nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10266(2-(4-fluorophenyl)-N-(1,3,4-trioxo-1,2,3,4-tetrahy...)
Affinity DataIC50: 199nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10286(N-Phenyl-N-(1,3,4-trioxo-1,2,3,4-tetrahydro-isoqui...)
Affinity DataIC50: 201nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10248(2-methyl-1,2,3,4-tetrahydroisoquinoline-1,3,4-trio...)
Affinity DataIC50: 255nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10249(2-Allylisoquinoline-1,3,4-trione | 2-(prop-2-en-1-...)
Affinity DataIC50: 261nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10293(N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-7-yl...)
Affinity DataIC50: 262nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10273(Cyclohexanecarboxylic acid (1,3,4-trioxo-1,2,3,4-t...)
Affinity DataIC50: 272nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM29582(isatin Michael acceptor (IMA) analogue, 18a)
Affinity DataIC50: 323nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10250(2-benzyl-1,2,3,4-tetrahydroisoquinoline-1,3,4-trio...)
Affinity DataIC50: 331nMpH: 7.5 T: 2°CAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10265(2-(4-nitrophenyl)-N-(1,3,4-trioxo-1,2,3,4-tetrahyd...)
Affinity DataIC50: 356nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM29584(isatin Michael acceptor (IMA) analogue, 18c)
Affinity DataIC50: 365nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
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